WO2018180758A1 - Barrel assembly, method of using syringe, medicinal liquid injection apparatus, and assembly method thereof - Google Patents

Barrel assembly, method of using syringe, medicinal liquid injection apparatus, and assembly method thereof Download PDF

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Publication number
WO2018180758A1
WO2018180758A1 PCT/JP2018/010999 JP2018010999W WO2018180758A1 WO 2018180758 A1 WO2018180758 A1 WO 2018180758A1 JP 2018010999 W JP2018010999 W JP 2018010999W WO 2018180758 A1 WO2018180758 A1 WO 2018180758A1
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WO
WIPO (PCT)
Prior art keywords
pusher
gasket
rotation
barrel
rib
Prior art date
Application number
PCT/JP2018/010999
Other languages
French (fr)
Japanese (ja)
Inventor
有延学
沖原等
百貫祐亮
飯渕るり子
桝田多恵子
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2019509586A priority Critical patent/JPWO2018180758A1/en
Publication of WO2018180758A1 publication Critical patent/WO2018180758A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms

Definitions

  • the present invention relates to a barrel assembly including a gasket and a pusher, a method of using a syringe, a chemical solution administration device, and an assembly method thereof.
  • a barrel assembly including a cylindrical body that can be filled with a chemical solution, a gasket that is slidably disposed in the cylindrical body, and a pusher that presses the gasket and moves the gasket in the distal direction is known.
  • a syringe that pushes out the chemical liquid filled in the barrel when the user presses the pusher in the distal direction with a finger (see, for example, JP-A-2013-192577).
  • a liquid feeding mechanism portion of a syringe pump type liquid medicine administration device that pushes the pusher forward by the drive portion to push out the liquid medicine filled in the cylinder body from the inside of the cylinder body and administer it into the living body.
  • a liquid feeding mechanism portion of a syringe pump type liquid medicine administration device that pushes the pusher forward by the drive portion to push out the liquid medicine filled in the cylinder body from the inside of the cylinder body and administer it into the living body.
  • connection structure between the gasket and the pusher is such that a female screw provided on the gasket and a male screw provided on the tip of the pusher are screwed together. It is common. For this reason, the conventional barrel assembly does not have a structure that prevents the relative rotation between the pusher and the gasket and prevents the pusher from being detached from the gasket.
  • the present invention has been made in consideration of such problems, and uses a barrel assembly and a syringe that can prevent relative rotation between the pusher and the gasket and prevent the pusher from being detached from the gasket. It is an object of the present invention to provide a method, a drug solution administration device, and an assembly method thereof.
  • a barrel assembly of the present invention is configured to be connected to a gasket that can be filled with a chemical solution, a gasket that is slidably disposed in the barrel, and the gasket.
  • a pusher capable of pressing the gasket in the tip direction, and one of the gasket and the pusher is provided with a rotation prevention groove, and the other of the gasket and the pusher is provided with the rotation prevention groove.
  • An anti-rotation protrusion configured to be inserted into the anti-rotation protrusion, and the engagement between the anti-rotation groove and the anti-rotation protrusion prevents relative rotation between the gasket and the pusher, and the gasket.
  • first Ribs are provided, by the engagement between the second rib and the first rib, withdrawal of the pusher from the gasket is prevented.
  • the relative rotation between the gasket and the pusher is prevented by the engagement between the rotation prevention groove and the rotation prevention protrusion, and the engagement between the first rib and the second rib allows the Removal of the pusher from the gasket is prevented. For this reason, it becomes possible to prevent relative rotation between the pusher and the gasket and to prevent the pusher from being detached from the gasket.
  • the rotation prevention groove may be provided in the gasket, and the rotation prevention protrusion may be provided in the pusher.
  • This structure makes it possible to easily provide a rotation prevention structure between the gasket and the pusher.
  • the gasket has a recess opening in a base end surface of the gasket, the pusher has a distal end inserted into the recess, and the rotation prevention groove is provided on an inner peripheral surface of the recess.
  • the rotation preventing projection may be provided on the outer peripheral surface of the tip of the pusher and extend along the axis of the pusher.
  • This configuration improves the rigidity of the anti-rotation groove and anti-rotation protrusion. For this reason, the engagement force between the groove for preventing rotation and the protrusion for preventing rotation is increased, and a better anti-rotation function can be obtained.
  • the gasket has a recess opening in a base end surface of the gasket, the pusher has a distal end portion inserted into the recess, and the first rib is provided on an inner peripheral surface of the recess. It extends in the circumferential direction, and the second rib may be provided on the outer peripheral surface of the tip portion of the pusher and extend in the circumferential direction.
  • This configuration improves the rigidity of the first rib and the second rib. For this reason, the engagement force of the 1st rib and the 2nd rib is raised, and a further better detachment prevention function is obtained.
  • the gasket has a recess opening in the base end surface of the gasket, the pusher has a distal end portion inserted into the recess, and the recess has a first recess opening in the base end surface of the gasket. And a second recess formed concentrically with the first recess and adjacent to the distal end side of the first recess and having a smaller diameter than the first recess, and the anti-rotation groove includes the second recess
  • the rotation preventing projection is provided on the outer peripheral surface of the tip end portion on the tip side of the second rib and is provided on the inner peripheral surface of the gasket.
  • the first rib is provided on the inner peripheral surface of the first recess and extends in the circumferential direction
  • the second rib is provided on the outer peripheral surface of the tip portion of the pusher. And extending in the circumferential direction, the protrusion of the anti-rotation protrusion
  • the end face may be located radially inward of the projecting end face of the second rib.
  • An anti-rotation portion comprising an anti-rotation groove and an anti-rotation protrusion is provided on the tip side of the separation preventing portion comprising the first rib and the second rib, and the rotation prevention portion is provided by the separation prevention portion. Is also provided on the inner side in the radial direction, the gasket and the pusher can be connected without hindrance in the assembly process.
  • a plurality of the rotation preventing grooves may be provided around the gasket axis at intervals of 5 to 20 °.
  • the anti-rotation groove and the anti-rotation groove are not closely aligned with each other when the pusher is attached to the gasket.
  • the rotation preventing protrusion can be engaged.
  • a plurality of the rotation preventing projections are provided around the axis of the pusher, and the number of the rotation preventing projections may be smaller than that of the rotation preventing grooves.
  • This configuration makes it possible to more easily engage the anti-rotation groove with the anti-rotation protrusion.
  • a plurality of the first ribs may be provided at intervals in the circumferential direction, and the second rib may be formed in an annular shape that extends once in the circumferential direction.
  • the separation preventing function can be exhibited regardless of the relative position in the circumferential direction between the gasket and the pusher, and the separation preventing ability can be improved.
  • the barrel assembly is a syringe in which the pusher is pushed by a user, and a filling space formed by the barrel and the gasket may be filled with a chemical solution.
  • This configuration allows the gasket to be interlocked and rotated in the barrel by rotating the pusher, so that the gasket can be easily released from the barrel inner surface before use of the syringe. By releasing the sticking, the initial sliding resistance can be lowered. That is, in general, there is a case where an operation of pushing the pusher is performed before using the syringe, and there is a possibility of liquid leakage and accompanying contamination. The possibility described above can be reduced by applying the barrel assembly of the present invention to a syringe.
  • the base end of the pusher may be provided with a pusher flange protruding outward, and the outer periphery of the pusher flange may be provided with a groove or a protrusion for hooking a finger.
  • This configuration makes it easy to rotate the pusher.
  • the pusher is inserted into the barrel through a base end opening of the barrel, and a flange portion projecting outward is provided at a base end portion of the barrel, and the barrel assembly includes the flange A rotation assisting member configured to be mounted on a portion, the rotation assisting member projecting inward and having a pusher rotation projection facing the proximal end opening of the barrel; Is provided with an inclined portion that is opposed to the pusher rotation protrusion on the proximal side of the pusher rotation protrusion when the pusher is in the initial position and is inclined with respect to the pusher axis. When the pusher advances in the distal direction, the pusher may rotate by the inclined portion being pushed by the pusher rotation protrusion.
  • the pusher has a pressing part capable of pressing the gasket in the distal direction, and the gasket has a pressed part provided at a position facing the pressing part, and in the initial state of the syringe,
  • the pressing portion and the pressed portion are spaced apart in the axial direction, and when the pusher moves forward in the distal direction, the pressing portion is the pressed portion of the gasket after the pusher starts to rotate. You may contact.
  • the present invention is a syringe provided with a barrel filled with a chemical, a gasket slidably disposed in the barrel, and a pusher connected to the gasket and capable of pressing the gasket in a distal direction.
  • the one of the gasket and the pusher is provided with a rotation prevention groove, and the other of the gasket and the pusher is provided with a rotation prevention protrusion inserted into the rotation prevention groove. Relative rotation between the gasket and the pusher is prevented by engaging the rotation preventing groove with the rotation preventing projection, and the gasket is provided with a first rib projecting in the radial direction.
  • the pusher is provided with a second rib that protrudes in the radial direction and engages with or faces the tip surface of the first rib, and the first rib and the second rib By engagement Detachment of the pusher from the gasket is prevented, and the method of use is to rotate the pusher before moving the gasket forward, so that the rotation prevention groove and the rotation prevention protrusion are engaged.
  • This configuration makes it possible to easily release the gasket from adhering to the inner surface of the barrel before using the syringe.
  • the present invention is also a chemical solution administration device for administering a chemical solution into a living body, wherein any of the barrel assemblies described above, a drive unit that advances the pusher of the barrel assembly in the distal direction, A barrel assembly and a housing for accommodating the drive unit, wherein the barrel has a flange portion having a major axis and a minor axis at a proximal end portion, and the pusher is a distal end connected to the gasket And a rod portion provided with a slot opened on the outer peripheral surface of the pusher, and the drive portion has a feed screw inserted into the slot, and the short shaft of the flange portion and the rod The opening direction of the slot of the rod part substantially coincides.
  • the barrel assembly is easily arranged at a predetermined position in the housing in a state in which the phase around the axis of the barrel and the pusher is adjusted to an appropriate position and the position is maintained. It becomes possible. Therefore, when the barrel assembly is disposed in the housing, the distance between the gasket and the pusher is not changed, and the gasket is not moved, so that liquid leakage and accompanying contamination can be prevented. .
  • the present invention also relates to a method of assembling a chemical solution administration device for administering a chemical solution into a living body, wherein the chemical solution administration device is provided with a flange portion having a major axis and a minor axis at a proximal end portion, A gasket that is slidably disposed in the barrel, a tip portion connected to the gasket, and a rod portion provided with a slot that opens to an outer peripheral surface.
  • a pusher that can push the pusher in the tip direction, a drive unit that has a feed screw inserted in the slot, and advances the pusher in the tip direction, and a barrel assembly that has the barrel, the gasket, and the pusher And a housing for accommodating the drive unit, wherein one of the gasket and the pusher is provided with a rotation preventing groove, and the other of the gasket and the pusher is provided with the rotation preventing groove.
  • An anti-rotation protrusion inserted into the gasket, the gasket is provided with a first rib projecting radially toward the pusher, and the pusher projects radially toward the gasket.
  • a second rib that engages with or faces the tip surface of the first rib
  • the assembly method includes a gasket insertion step of inserting the gasket at a predetermined position in the barrel;
  • the first rib and the second rib are engaged with each other while the minor axis of the flange portion and the opening direction of the slot of the rod portion are substantially aligned, and the rotation preventing groove is rotated.
  • the sea urchin said barrel assembly including a placement step of placing in said housing.
  • FIG. 4A is a perspective view of the gasket.
  • FIG. 4B is a cross-sectional view of the gasket.
  • FIG. 5 is a sectional view taken along line VV in FIG. 3. It is a perspective view of the front end side of a pusher. It is a perspective view of the syringe which is a barrel assembly which concerns on 2nd Embodiment of this invention. It is a principal part expanded sectional view of the syringe shown in FIG.
  • FIG. 10A is a first explanatory view of a method of using the syringe shown in FIG.
  • FIG. 10B is a second explanatory diagram of a method of using the syringe shown in FIG.
  • FIG. 10A is a first explanatory view of a method of using the syringe shown in FIG.
  • FIG. 10B is a second explanatory diagram of a method of using the syringe shown in FIG.
  • FIG. 17A is a second explanatory diagram (perspective view) of a connection step in the method of assembling the drug solution administration device.
  • FIG. 17B is a second explanatory diagram (cross-sectional view) of a connection step in the method of assembling the drug solution administration device. It is a 3rd explanatory drawing of the assembly method of a chemical
  • the barrel assembly 10A according to the first embodiment of the present invention shown in FIGS. 1 and 2 is connected to the hollow barrel 12, the gasket 14 slidably disposed in the barrel 12, and the gasket 14.
  • a pusher 16 capable of pressing the gasket 14 in the distal direction is provided.
  • This barrel assembly 10A is a syringe 11A in which the pusher 16 is pushed by the user.
  • the syringe 11A is a prefilled syringe in which a drug solution M is filled in advance in a filling space 13 formed by the barrel 12 and the gasket 14 at the time of product provision.
  • the barrel 12 has a substantially cylindrical shape and a trunk portion 12a having a proximal end opening formed at the proximal end, a shoulder portion 12b having a diameter reduced from the distal end portion of the trunk portion 12a, and a distal end of the barrel portion 12a. It has a nozzle 12c and a flange portion 12d that protrudes radially outward from the base end of the body portion 12a.
  • the nozzle 12c has a diameter reduced from the center of the front end of the body 12a with respect to the body 12a and extends in the front end direction.
  • the flange portion 12d is formed in a non-circular shape having a short axis and a long axis.
  • the gasket 14 is inserted into the barrel 12 through a proximal end opening that opens at the proximal end of the body 12a.
  • the proximal end side of the barrel 12 is liquid-tightly sealed by the gasket 14.
  • the gasket 14 is made of an elastic material such as a rubber material.
  • the outer periphery of the gasket 14 is in liquid-tight contact with the inner peripheral surface of the body 12a and is slidably disposed in the body 12a.
  • the gasket 14 is provided with a rotation preventing groove 20 and a first rib 30 projecting radially toward the pusher 16.
  • the gasket 14 has a recess 22 that opens to the proximal end surface 14 a of the gasket 14.
  • the recess 22 has a first recess 22a that is open on the base end surface 14a of the gasket 14, a concentric shape with the first recess 22a, adjacent to the distal end side of the first recess 22a, and a smaller diameter than the first recess 22a. 2 recesses 22b.
  • shaft of the gasket 14 of the 1st recessed part 22a and the 2nd recessed part 22b is substantially circular.
  • the rotation preventing groove 20 is provided on the inner peripheral surface of the second recess 22b and extends along the axis of the gasket 14.
  • a plurality of anti-rotation grooves 20 are provided at equal intervals in the circumferential direction so as to surround the shaft of the gasket 14.
  • the plurality of anti-rotation grooves 20 form an annular concavo-convex structure on the inner peripheral surface of the second recess 22b.
  • the rotation preventing groove 20 is provided on the radially inner side with respect to the first rib 30.
  • the rotation preventing grooves 20 are provided around the axis of the gasket 14, for example, at intervals of 5 to 20 °, and preferably at intervals of 5 to 10 °.
  • channel 20 for rotation prevention means the angle of the circumferential direction center position of the groove
  • the first rib 30 is provided on the inner peripheral surface of the first recess 22a and extends in the circumferential direction.
  • a plurality of first ribs 30 are provided at intervals in the circumferential direction (four in the illustrated example at equal intervals in the circumferential direction).
  • a plurality of convex portions 14b are provided at the base end portion of the gasket 14 at intervals in the circumferential direction.
  • the plurality of convex portions 14 b protrude from the base end surface 14 a of the gasket 14 in the base end direction.
  • a plurality of notch grooves 14 c are provided at the base end portion of the gasket 14 at intervals in the circumferential direction.
  • the plurality of cutout grooves 14c are open on the base end surface 14a of the gasket 14 and the inner peripheral surface of the recess 22 (first recess 22a).
  • the pusher 16 includes a shaft portion 24 that constitutes a main portion (body) of the pusher 16, and a distal end portion 26 that protrudes from the distal end of the shaft portion 24 in the distal direction and is connected to the gasket 14. And a pusher flange 28 protruding outward in the radial direction from the base end of the shaft portion 24.
  • the shaft portion 24 has four plate-like ribs 24 a that extend along the axis of the pusher 16 and project radially from the axis of the pusher 16. Due to the four plate-like ribs 24a, the cross-sectional shape of the shaft portion 24 in a plane perpendicular to the axis of the pusher 16 is formed in a cross shape.
  • the tip end portion 26 is inserted into the recess 22 of the gasket 14.
  • the distal end portion 26 is provided with a distal end concave portion 27 that opens in the distal direction.
  • tip part 26 is comprised by the hollow shape.
  • a groove portion 28 a for hooking a user's finger is provided on the outer peripheral portion of the pusher flange 28.
  • a plurality of grooves 28a are provided at intervals in the circumferential direction. Only one groove 28a may be provided.
  • a protrusion for hooking a user's finger may be provided on the outer peripheral portion of the pusher flange 28 in place of or in addition to the groove portion 28a. In this case, only one finger hooking projection may be provided, or a plurality of projections may be provided at intervals in the circumferential direction.
  • the pusher 16 is provided with an anti-rotation protrusion 21 inserted into the anti-rotation groove 20 and a second rib 31 protruding radially outward toward the gasket 14. It has been.
  • the rotation preventing projection 21 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16 and extends along the axis of the pusher 16.
  • the rotation preventing projection 21 is provided on the tip side of the second rib 31.
  • a plurality (four in the illustrated example) of anti-rotation protrusions 21 are provided at intervals in the circumferential direction.
  • the protruding end surface of the rotation preventing protrusion 21 is located on the radially inner side than the protruding end surface of the second rib 31. Relative rotation between the gasket 14 and the pusher 16 is prevented by the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21.
  • the second rib 31 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16, extends in the circumferential direction, and engages with the distal end surface of the first rib 30.
  • the second rib 31 may be spaced apart from the tip surface of the first rib 30 in the tip direction and may face the tip surface.
  • the 2nd rib 31 is formed in the cyclic
  • the 1st rib 30 may be formed in the cyclic
  • a rotation prevention groove is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16, and the rotation prevention groove is inserted into the inner peripheral surface of the recess 22 of the gasket 14.
  • a protrusion may be provided.
  • a rotation preventing groove may be provided on the base end surface 14a of the gasket 14, and a rotation preventing projection inserted into the rotation preventing groove may be provided on the distal end surface 24b of the shaft portion 24.
  • a rotation prevention groove may be provided on the distal end surface 24b of the shaft portion 24, and a rotation prevention protrusion inserted into the rotation prevention groove may be provided on the proximal end surface 14a of the gasket 14.
  • the gasket 14 is provided with a first rib projecting radially outward, and the pusher 16 is provided with a second rib projecting radially inward.
  • first rib and second rib Detachment of the pusher 16 from the gasket 14 may be prevented.
  • the barrel assembly 10A according to this embodiment configured as described above has the following effects.
  • the relative rotation between the gasket 14 and the pusher 16 is prevented by the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21, and the first rib 30 and the second rib 31 are separated from each other.
  • the engagement prevents the pusher 16 from being detached from the gasket 14. For this reason, relative rotation between the pusher 16 and the gasket 14 can be prevented, and separation of the pusher 16 from the gasket 14 can be prevented.
  • the barrel assembly 10A is a syringe 11A in which the pusher 16 is pushed by the user, and the filling space 13 formed by the barrel 12 and the gasket 14 is filled with the chemical solution M.
  • the following usage method can be implemented using the syringe 11A.
  • the pusher 16 is rotated to rotate the gasket 14 in the barrel 12 through the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21 (rotation step).
  • rotation step the gasket 14 is released from the inner surface of the barrel 12.
  • the gasket 14 is advanced in the barrel 12 by advancing the pusher 16 after at least the gasket 14 starts to rotate (advancing step).
  • the advance timing of the advance step may be after the start of the rotation of the pusher 16 by the rotation step. For this reason, the user only has to push the pusher 16 in the distal direction after gripping and rotating the pusher 16.
  • the pusher 16 may be connected to the gasket 14 immediately before using the syringe 11A.
  • the gasket 14 can be rotated in the barrel 12 by rotating the pusher 16, so that the gasket 14 can be applied to the inner surface of the barrel 12 before the syringe 11A is used. Fixing can be easily released. By releasing the sticking, the initial sliding resistance of the gasket 14 can be lowered. That is, in general, there is a case where an operation of pushing the pusher is performed before using the syringe, and there is a possibility of liquid leakage and accompanying contamination. By applying the barrel assembly 10A to the syringe 11A, the above possibility can be reduced.
  • the rotation prevention groove 20 is provided in the gasket 14, and the rotation prevention protrusion 21 is provided in the pusher 16. With this configuration, a structure for preventing rotation between the gasket 14 and the pusher 16 can be easily provided.
  • the gasket 14 has a recess 22 that opens to the base end surface 14 a of the gasket 14, and the pusher 16 has a distal end portion 26 that is inserted into the recess 22.
  • the rotation preventing groove 20 is provided on the inner peripheral surface of the recess 22 and extends along the axis of the gasket 14.
  • the rotation preventing projection 21 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16 and extends along the axis of the pusher 16.
  • the first rib 30 is provided on the inner peripheral surface of the recess 22 and extends in the circumferential direction
  • the second rib 31 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16 and extends in the circumferential direction.
  • the recess 22 has a first recess 22a that is open on the base end surface 14a of the gasket 14, a concentric shape with the first recess 22a, adjacent to the distal end side of the first recess 22a, and a smaller diameter than the first recess 22a. 2 recesses 22b.
  • the anti-rotation groove 20 is provided on the inner peripheral surface of the second recess 22 b, and the anti-rotation protrusion 21 is provided on the outer peripheral surface of the front end portion 26 on the front end side of the second rib 31.
  • the first rib 30 is provided on the inner peripheral surface of the first recess 22 a, and the second rib 31 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16.
  • the protruding end surface of the rotation preventing protrusion 21 is located on the radially inner side with respect to the protruding end surface of the second rib 31.
  • the anti-rotation portion composed of the anti-rotation groove 20 and the anti-rotation protrusion 21 is provided on the tip side of the anti-detachment portion composed of the first rib 30 and the second rib 31, and the anti-rotation portion is provided.
  • the portion is provided on the radially inner side than the separation preventing portion.
  • a plurality of anti-rotation grooves 20 are provided around the axis of the gasket 14 at intervals of 5 to 20 °. By providing a plurality of anti-rotation grooves 20 at such intervals, when the pusher 16 is mounted on the gasket 14, the positions of the anti-rotation grooves 20 and the anti-rotation protrusions 21 are not strictly aligned, The rotation preventing groove 20 and the rotation preventing projection 21 can be engaged with each other.
  • a plurality of rotation prevention protrusions 21 are provided around the axis of the pusher 16, and the number of rotation prevention protrusions 21 is smaller than that of the rotation prevention grooves 20. With this configuration, the rotation prevention groove 20 and the rotation prevention protrusion 21 can be more easily engaged.
  • a plurality of first ribs 30 are provided at intervals in the circumferential direction, and the second ribs 31 are formed in an annular shape that extends once in the circumferential direction.
  • a pusher flange 28 that protrudes outward is provided at the proximal end of the pusher 16, and a groove 28 a or a protrusion for hooking a finger is provided on the outer periphery of the pusher flange 28. With this configuration, the pusher 16 can be easily rotated.
  • the barrel assembly 10B according to the second embodiment of the present invention shown in FIG. 7 is filled with the chemical solution M in the barrel 12, and the pusher 16a is pushed by the user so that the chemical solution is obtained. It is configured as a syringe 11B that pushes out M.
  • the rotation auxiliary member 36 is attached to the barrel 12.
  • the rotation assisting member 36 has a pusher rotation protrusion 38 that protrudes inward and faces the proximal end opening of the barrel 12.
  • the rotation assisting member 36 includes a U-shaped base plate 40 having a base portion 40a and a pair of arm portions 40b extending from the base portion 40a, and a first portion provided on the base portion 40a of the base plate 40.
  • An engagement claw 42 and two second engagement claws 44 provided on the free end side of the pair of arm portions 40b of the base plate 40 are provided.
  • the first engagement claw 42 engages with the edge on one end side in the short axis direction of the flange portion 12d of the barrel 12, and the second engagement claw 44 has the short axis of the flange portion 12d. It is engaged with the edge on the other end side in the direction.
  • the pusher rotation protrusion 38 protrudes inward from the base portion 40a.
  • a rotation guide 46 is provided on the shaft portion 24 of the pusher 16a.
  • the rotation guide 46 is provided so as to bulge from the surface of the plate-like rib 24 a of the shaft portion 24.
  • the rotation guide 46 has an inclined portion 48 (inclined surface) inclined with respect to the axis of the pusher 16a.
  • the inclined portion 48 is inclined so that the distance from the surface of the plate-like rib 24a increases in the proximal direction.
  • the inclined portion 48 is opposed to the pusher rotation protrusion 38 on the proximal side with respect to the pusher rotation protrusion 38 when the pusher 16a is in the initial position.
  • the inclined portion 48 may or may not be in contact with the pusher rotation protrusion 38. If the inclined portion 48 is not in contact with the pusher rotation protrusion 38 when the pusher 16a is in the initial position, the inclined portion 48 is preferably located in the vicinity of the pusher rotation protrusion 38.
  • the pusher flange 29 provided at the base end portion of the shaft portion 24 in FIG.
  • the pusher 16a has a pressing portion 50 capable of pressing the gasket 14A in the distal direction.
  • the pressing part 50 is configured by a tip surface 24 b of the shaft part 24.
  • the gasket 14 ⁇ / b> A has a pressed portion 52 provided at a position facing the pressing portion 50.
  • the pressed portion 52 is configured by a base end portion (base end surface 14a and convex portion 14b) of the gasket 14A. In the initial state of the syringe 11B, the pressing portion 50 and the pressed portion 52 are separated in the axial direction.
  • the gasket 14A includes a recess 23 having a first recess 23a and a second recess 23b adjacent to each other in the axial direction.
  • the first recess 23a and the second recess 23b are respectively formed deeper in the axial direction than the first recess 22a and the second recess 22b of the gasket 14 described above.
  • the anti-rotation groove 20 a provided on the inner peripheral surface of the second recess 23 b is formed longer in the axial direction than the anti-rotation groove 20 of the gasket 14.
  • the distal end portion 26a of the pusher 16a inserted into the recess 23 is configured to be longer in the axial direction than the distal end portion 26 of the pusher 16 described above.
  • the distal end surface of the distal end portion 26a of the pusher 16a and the bottom surface 23c of the concave portion 23 of the gasket 14A are larger than the axial separation distance between the pressing portion 50 and the pressed portion 52. Are spaced apart in the axial direction.
  • the pressing portion 50 and the pressed portion 52 are not limited to the above combination.
  • the tip surface of the tip portion 26a of the pusher 16a forms a pressing portion
  • the bottom surface 23c (second recess portion) of the recess 23 of the gasket 14A may constitute the pressed part.
  • the pusher 16a is rotated by the inclined portion 48 being pushed by the pusher rotation protrusion 38 when the pusher 16a moves forward in the distal direction. That is, as shown in FIG. 10A, when the user pushes the pusher 16a in the distal direction, the pusher 16a starts to move forward with respect to the barrel 12, and the inclined portion 48 also moves forward. At this time, due to the action of the pusher rotation projection 38 and the inclined portion 48, a part of the force that the pusher 16 a moves forward is converted into a force that rotates the pusher 16 a.
  • the gasket 14A can be easily rotated by performing an operation of pushing the pusher 16a in the distal direction. For this reason, before use of the syringe 11B, the sticking release of the gasket 14A can be more easily performed.
  • a rotation assisting member 36A shown in FIG. 11 may be used.
  • the rotation assisting member 36A has a U-shaped mounting groove 54 into which the flange portion 12d of the barrel 12 can be inserted, and is slid along the distal end surface and the proximal end surface of the flange portion 12d from the side of the barrel 12. It is configured to be attachable to the portion 12d. With this configuration, the rotation assisting member 36A can be easily attached to the flange portion 12d.
  • the medicinal solution administration device 56 continuously administers the medicinal solution M filled in the barrel 66 into the living body under a pressing action of the pusher 70 over a relatively long time (for example, several minutes to several hours).
  • the chemical solution administration device 56 may intermittently administer the chemical solution M into the living body.
  • the drug solution M include protein preparations, narcotic analgesics, diuretics and the like.
  • a patch-type needle-attached tube 59 is connected to the drug solution administration device 56 as the administration device 58, and the drug solution M discharged from the barrel 66 passes through the needle-attached tube 59 to the body of the patient. Injected into.
  • the tube 59 with a needle is connected to a connector 60 that can be connected to the tube tip 66 c of the barrel 66, a flexible liquid feeding tube 61 having one end connected to the connector 60, and the other end of the liquid feeding tube 61.
  • a patch portion 62 that can be attached to the skin S and a puncture needle 63 protruding from the patch portion 62 are provided.
  • the puncture needle 63 is punctured substantially perpendicular to the skin S.
  • the puncture needle 63 may be punctured obliquely with respect to the skin S.
  • the administration device 58 connected to the drug solution administration device 56 is not limited to the above-described patch-type tube 59 with a needle, and is, for example, a device in which a puncture needle (such as a winged needle) is connected to the tip of the liquid delivery tube 61. May be.
  • the administration device 58 may be a bent needle that can be connected to the tube tip portion 66 c of the barrel 66 without using the liquid feeding tube 61.
  • the bent needle is bent, for example, approximately 90 ° downward from the tube tip 66c of the barrel 66, and punctures perpendicularly to the skin S as the drug solution administration device 56 is fixed (attached) to the skin S. Is done.
  • the barrel tip portion 66c of the barrel 66, the administration device 58, and a part of the needle may be inside the barrel 66, and the tip of the needle may protrude from the barrel 66. Even in this case, the needle is punctured perpendicularly to the skin S as the drug solution administration device 56 is fixed (attached) to the skin S.
  • the medicinal solution administration device 56 is connected to the barrel 66 filled with the medicinal solution M, the gasket 68 slidably disposed in the barrel 66, and connected to the gasket 68 and the barrel 66.
  • a pusher 70 that is movable in the axial direction with respect to the actuator, a drive unit 72 that advances the pusher 70 in the distal direction, and a barrel assembly 10C that includes the barrel 66, the gasket 68, and the pusher 70, and the drive unit 72 are accommodated.
  • a housing 74 a housing 74.
  • a battery for supplying power necessary for the operation of the drug solution administration device 56, a control unit (microcomputer) for controlling the operation of the drug solution administration device 56, a speaker, and the like are arranged in the housing 74.
  • the housing 74 has an upper housing 74A and a lower housing 74B.
  • the housing 74 is provided with a plurality of buttons 76a to 76d for various operations and a plurality of light emitting portions 78a and 78b for informing the operation state of the drug solution administration device 56 and the like.
  • the barrel 66 is formed in a hollow cylindrical shape having a filling space 67 for the chemical solution M therein. As shown in FIGS. 13 and 14, the barrel 66 has an inner diameter and an outer diameter that are constant in the axial direction and a base end that is open at the base end, and an inner diameter and an outer diameter that extend from the distal end of the barrel 66a toward the distal end. It has a shoulder portion 66b whose diameter is reduced in a tapered shape, a tube tip portion 66c protruding from the shoulder portion 66b in the distal direction, and a flange portion 66d protruding outward in the radial direction from the base end of the body portion 66a.
  • a chemical discharge port 66e communicating with the filling space 67 is formed in the tube tip portion 66c.
  • the lumen of the tube tip portion 66c constitutes a flow path that connects the chemical solution discharge port 66e and the filling space 67.
  • the flange portion 66d is formed in a non-circular shape having a major axis and a minor axis.
  • the chemical solution M is filled in the barrel 66 in advance.
  • the drug solution M may be filled in the barrel 66 immediately before using the drug solution administration device 56.
  • the chemical solution discharge port 66e is liquid-tightly sealed by a sealing member 69 made of an elastic resin material such as a rubber material or an elastomer material.
  • the sealing member 69 is punctured by a needle 60a provided on the connector 60 when the connector 60 shown in FIG. 12 is connected to the tube tip portion 66c.
  • the sealing member 69 is fixed to the tip of the barrel 66 by a cap 73 having an opening at the tip. The distal end surface of the sealing member 69 is exposed from the opening of the cap 73.
  • the gasket 68 is made of an elastic resin material such as a rubber material or an elastomer material, and the outer peripheral portion thereof is in liquid-tight contact with the inner peripheral surface of the barrel 66 (body portion 66a), so that the base end side of the filling space 67 is liquid-filled. Closely closed. Similar to the gasket 14 shown in FIG. 3 and the like, the gasket 68 has a first recess 22a in which the rotation preventing groove 20 is provided on the inner peripheral surface, and a second rib in which the first rib 30 is provided on the inner peripheral surface. A recess 22 having a recess 22b is provided.
  • the pusher 70 is a member that can move in the axial direction in order to push out the chemical M.
  • a gasket 68 is connected to the distal end portion 26 of the pusher 70.
  • the pusher 70 includes a rod portion 80 that constitutes a main portion (body) of the pusher 70, and a distal end portion 26 that protrudes from the distal end of the rod portion 80 in the distal direction and is connected to the gasket 68.
  • the distal end portion 26 of the pusher 70 is inserted into the concave portion 22 of the gasket 68.
  • the distal end portion 26 has the same configuration as the distal end portion 26 of the pusher 16 shown in FIG.
  • the rod portion 80 is provided with a slot 80 a that extends along the axis of the pusher 70 and opens to the outer peripheral surface (lower surface) of the rod portion 80.
  • the slot 80 a is also opened in the proximal direction at the proximal end portion of the rod portion 80.
  • the drive unit 72 includes an advance mechanism 82 that advances the pusher 70 in the distal direction, and a drive mechanism 84 that drives the advance mechanism 82 to advance the pusher 70 in the distal direction.
  • the drive mechanism 84 includes a motor 85 (for example, a geared motor) and a pinion 86 that is a drive gear fixed to the output shaft of the motor 85.
  • the advance mechanism 82 includes a feed screw 88 that is rotationally driven by a pinion 86 and a nut member 90 that is screwed into the feed screw 88.
  • the feed screw 88 is disposed along the axis of the barrel 66 and is inserted into the slot 80 a of the pusher 70.
  • the feed screw 88 includes a large gear 88a that is a driven gear that meshes with the pinion 86, and a male screw 88b that is formed on the outer peripheral surface on the tip side of the large gear 88a over a predetermined range in the axial direction.
  • the proximal end portion of the feed screw 88 is rotatably supported by a support member 93 fixed to the chassis member 92.
  • the distal end portion 26 of the feed screw 88 is rotatably supported by a distal end side support member 94 fixed to the chassis member 92.
  • the nut member 90 is a female screw portion that is made of, for example, a hard resin material and has a female screw 91 (screw hole) into which the male screw 88b of the feed screw 88 is screwed. As the feed screw 88 rotates, the nut member 90 moves in the axial direction.
  • the nut member 90 includes a nut main body 90a in which a female screw 91 is formed, and a slide portion 90b provided at one end of the nut main body 90a.
  • the nut member 90 may be omitted and the pusher 70 may be provided with the female screw 91 and the slide portion 90b.
  • a pair of holes 90c penetrating in the axial direction is formed in the nut main body 90a, and a claw 80b (FIG. 15) provided at the base end of the rod 80 is engaged with the pair of holes 90c. ing.
  • a reinforcing cover 90d made of, for example, a metal material is attached to the outer surface of the nut main body 90a. The reinforcing cover 90d is held by a plurality of holding portions 80c provided at the proximal end of the pusher 70.
  • the slide portion 90 b is supported by a guide rail 89 that is fixed to the chassis member 92 and extends in parallel with the feed screw 88 so as to be slidable in the axial direction. For this reason, the nut member 90 can move smoothly in the axial direction of the pusher 70 as the feed screw 88 rotates.
  • the slide portion 90 b is inserted into a guide groove 89 a formed in the guide rail 89.
  • the guide groove 89 a extends along the axial direction of the pusher 70.
  • the barrel 66 and the drive unit 72 are fixed to the housing 74 via a chassis member 92 fixed to the lower housing 74B.
  • the chassis member 92 is fixed to the housing 74 by a plurality of fastening parts 95 (screws in the illustrated example).
  • the barrel 66 is fixed to the chassis member 92 by engaging with the chassis member 92 at the flange portion 66d.
  • the chassis member 92 includes a base plate portion 98 and a flange mounting portion 100 that protrudes from the upper surface of the base plate portion 98 in the thickness direction (upward) of the base plate portion 98 and has a flange portion 66d mounted thereon.
  • a support portion that supports the barrel 66 and the drive portion 72 may be provided integrally with the housing 74.
  • the chemical solution administration device 56 When using the chemical solution administration device 56, the chemical solution administration device 56 is taken out of the cold storage, left at room temperature, and returned to room temperature. Next, the surface (tip surface) of the sealing member 69 that is a connection portion with the connector 60 is wiped off with, for example, alcohol cotton, so that the connection portion is sterilized. Next, an administration device 58 is connected to the drug solution administration device 56.
  • the power button 76a when the power button 76a is pressed for a predetermined time or longer (long press), the first light emitting unit 78a is lit in the first color, the start sound is notified from the speaker, and the power is turned on.
  • the priming button 76b when the priming button 76b is continuously pressed, the first light emitting portion 78a blinks in the first color, and priming (filling the flow path in the administration device 58 with the drug solution M) is performed. In this case, the completion of the priming can be grasped by visually confirming that the chemical M has dripped from the needle tip 63a.
  • the drug solution administration device 56 is attached to the patient by being attached to the skin S or attached to clothes.
  • the puncture needle 63 is punctured into the skin S.
  • the chemical solution administration device 56 may be attached to the patient.
  • the first light emitting unit 54a blinks in the second color (color different from the first color), and liquid feeding (administration of the drug solution M) is started. .
  • the motor 85 is driven to rotate from the pinion 86 to the feeding screw 88 having the large gear 88a. Power is transmitted.
  • the feed screw 88 rotates, the nut member 90 screwed with the feed screw 88 moves forward, and the pusher 70 is pushed forward by the nut member 90 and moves forward.
  • medical solution M in the barrel 66 is extruded.
  • the medicinal solution M pushed out from the barrel 66 is administered (injected) into the patient's body through the administration device 58 punctured by the patient.
  • the cap 73 and the sealing member 69 are attached to the tube tip portion 66 c so that the sealing member 69 is sandwiched between the tip end surface of the tube tip portion 66 c of the barrel 66 and the cap 73.
  • the cap 73 engages with the outer peripheral portion of the tube tip portion 66c, and the tip opening is sealed in a liquid-tight manner by the sealing member 69.
  • the gasket 68 is inserted into the barrel 66 by, for example, a vacuum stopper method (gasket insertion step).
  • the first rib 30 and the second rib 31 are made with the short axis of the flange portion 66 d of the barrel 66 and the opening direction of the slot 80 a of the rod portion 80 being substantially coincident with each other.
  • the gasket 68 and the pusher 70 are connected by inserting the anti-rotation protrusion 21 into the anti-rotation groove 20 (connection step). Thereby, the barrel assembly 10C assembled in a predetermined state is obtained.
  • the barrel assembly 10C is disposed in the housing 74 so that the feed screw 88 is inserted into the slot 80a of the rod portion 80 (arrangement step).
  • an assembly is prepared in which the drive unit 72 is attached to the chassis member 92 and the chassis member 92 is fixed to the lower housing 74B.
  • the barrel assembly 10C is assembled to the lower housing 74B.
  • the flange portion 66 d of the barrel 66 is inserted and held in the flange mounting portion 100 of the chassis member 92.
  • the nut member 90 is advanced toward the pusher 70 by rotating the feed screw 88, and the base end portion of the pusher 70 and the nut member 90 are connected.
  • the claw portion 80b of the pusher 70 is inserted into the hole portion 90c of the nut member 90 while elastically deforming inward, and the claw portion 80b moves over the hole portion 90c so that the claw portion 80b becomes the base of the nut member 90. Engage with the end face.
  • the drug solution administration device 56 has the following effects.
  • the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21 prevents relative rotation between the barrel 66 and the pusher 70, and the relationship between the first rib 30 and the second rib 31. Accordingly, the pusher 70 is prevented from being detached from the barrel 66.
  • the barrel assembly 10C is brought into a predetermined position in the housing 74 in a state where the phase around the axis of the barrel 66 and the pusher 70 is adjusted to an appropriate position and the position is maintained. It can be easily arranged. For this reason, when the barrel assembly 10C is disposed in the housing 74, the distance between the gasket 68 and the pusher 70 is not changed, and the gasket 68 is not moved. Can be prevented.

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  • Biomedical Technology (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

This barrel assembly (10A) is provided with a barrel (12), a gasket (14) and a plunger (16). A rotation preventing groove (20) provided on one among the gasket (14) and the plunger (16), and a rotation preventing projection (21) provided on the other among the gasket (14) and the plunger (16) are engaged to prevent the relative rotation of the gasket (14) and the plunger (16). A first rib (30) formed on the gasket (14) and a second rib (31) formed on the plunger (16) are engaged to prevent the plunger (16) from being separated from the gasket (14).

Description

バレル組立体、シリンジの使用方法、薬液投与装置及びその組立方法Barrel assembly, method of using syringe, chemical solution administration device, and method of assembling the same
　本発明は、ガスケットと押し子とを備えたバレル組立体、シリンジの使用方法、薬液投与装置及びその組立方法に関する。 The present invention relates to a barrel assembly including a gasket and a pusher, a method of using a syringe, a chemical solution administration device, and an assembly method thereof.
　従来、薬液が充填可能な筒体と、筒体内に摺動可能に配置されたガスケットと、ガスケットを押圧して先端方向に移動させる押し子とを備えたバレル組立体は公知である。バレル組立体の一形態としては、ユーザが押し子を指で先端方向に押圧することによりバレル内に充填された薬液を押し出すシリンジがある（例えば、特開２０１３－１９２５７７号公報を参照）。バレル組立体の他の形態としては、駆動部により押し子を前進させることにより、筒体内に充填した薬液を筒体内から押し出して生体内に投与するシリンジポンプ型の薬液投与装置の送液機構部（筒体、ガスケット及び押し子）がある（例えば、特許第３５４６０１５号公報を参照）。 Conventionally, a barrel assembly including a cylindrical body that can be filled with a chemical solution, a gasket that is slidably disposed in the cylindrical body, and a pusher that presses the gasket and moves the gasket in the distal direction is known. As one form of the barrel assembly, there is a syringe that pushes out the chemical liquid filled in the barrel when the user presses the pusher in the distal direction with a finger (see, for example, JP-A-2013-192577). As another form of the barrel assembly, a liquid feeding mechanism portion of a syringe pump type liquid medicine administration device that pushes the pusher forward by the drive portion to push out the liquid medicine filled in the cylinder body from the inside of the cylinder body and administer it into the living body. (Cylinder, gasket and pusher) (see, for example, Japanese Patent No. 3546015).
　ところで、従来のバレル組立体では、ガスケットと押し子との接続は、ガスケットに設けられた雌ねじと、押し子の先端部に設けられた雄ねじとの螺合による接続構造が採用されているのが一般的である。このため、従来のバレル組立体では、押し子とガスケットとの相対回転が防止され且つガスケットからの押し子の離脱が防止された構造とはなっていない。 By the way, in the conventional barrel assembly, the connection structure between the gasket and the pusher is such that a female screw provided on the gasket and a male screw provided on the tip of the pusher are screwed together. It is common. For this reason, the conventional barrel assembly does not have a structure that prevents the relative rotation between the pusher and the gasket and prevents the pusher from being detached from the gasket.
　本発明はこのような課題を考慮してなされたものであり、押し子とガスケットとの相対回転を防止し且つガスケットからの押し子の離脱を防止することが可能なバレル組立体、シリンジの使用方法、薬液投与装置及びその組立方法を提供することを目的とする。 The present invention has been made in consideration of such problems, and uses a barrel assembly and a syringe that can prevent relative rotation between the pusher and the gasket and prevent the pusher from being detached from the gasket. It is an object of the present invention to provide a method, a drug solution administration device, and an assembly method thereof.
　上記の目的を達成するため、本発明のバレル組立体は、薬液が充填可能なバレルと、前記バレル内に摺動可能に配置されたガスケットと、前記ガスケットに接続されるように構成され、前記ガスケットを先端方向に押圧可能な押し子と、を備え、前記ガスケット及び前記押し子の一方には、回転防止用溝が設けられ、前記ガスケット及び前記押し子の他方には、前記回転防止用溝に挿入されるように構成された回転防止用突起が設けられ、前記回転防止用溝と前記回転防止用突起との係合により、前記ガスケットと前記押し子との相対回転が防止され、前記ガスケットには、径方向に突出した第１リブが設けられ、前記押し子には、径方向に突出するとともに、前記第１リブの先端面に係合し又は前記先端面に対向するように構成された第２リブが設けられ、前記第１リブと前記第２リブとの係合により、前記ガスケットからの前記押し子の離脱が防止される。 In order to achieve the above object, a barrel assembly of the present invention is configured to be connected to a gasket that can be filled with a chemical solution, a gasket that is slidably disposed in the barrel, and the gasket. A pusher capable of pressing the gasket in the tip direction, and one of the gasket and the pusher is provided with a rotation prevention groove, and the other of the gasket and the pusher is provided with the rotation prevention groove. An anti-rotation protrusion configured to be inserted into the anti-rotation protrusion, and the engagement between the anti-rotation groove and the anti-rotation protrusion prevents relative rotation between the gasket and the pusher, and the gasket. Is provided with a first rib projecting in the radial direction, and the pusher projects in the radial direction and is configured to engage with or face the tip surface of the first rib. First Ribs are provided, by the engagement between the second rib and the first rib, withdrawal of the pusher from the gasket is prevented.
　上記のバレル組立体によれば、回転防止用溝と回転防止用突起との係合により、ガスケットと押し子との相対回転が防止され、第１リブと第２リブとの係合により、前記ガスケットからの前記押し子の離脱が防止される。このため、押し子とガスケットとの相対回転を防止し且つガスケットからの押し子の離脱を防止することが可能となる。 According to the barrel assembly, the relative rotation between the gasket and the pusher is prevented by the engagement between the rotation prevention groove and the rotation prevention protrusion, and the engagement between the first rib and the second rib allows the Removal of the pusher from the gasket is prevented. For this reason, it becomes possible to prevent relative rotation between the pusher and the gasket and to prevent the pusher from being detached from the gasket.
　前記回転防止用溝は、前記ガスケットに設けられ、前記回転防止用突起は、前記押し子に設けられていてもよい。 The rotation prevention groove may be provided in the gasket, and the rotation prevention protrusion may be provided in the pusher.
　この構成により、ガスケットと押し子との回転防止構造を簡単に設けることができる。 This structure makes it possible to easily provide a rotation prevention structure between the gasket and the pusher.
　前記ガスケットは、前記ガスケットの基端面に開口する凹部を有し、前記押し子は、前記凹部に挿入される先端部を有し、前記回転防止用溝は、前記凹部の内周面に設けられるとともに前記ガスケットの軸に沿って延在し、前記回転防止用突起は、前記押し子の前記先端部の外周面に設けられるとともに前記押し子の軸に沿って延在していてもよい。 The gasket has a recess opening in a base end surface of the gasket, the pusher has a distal end inserted into the recess, and the rotation prevention groove is provided on an inner peripheral surface of the recess. The rotation preventing projection may be provided on the outer peripheral surface of the tip of the pusher and extend along the axis of the pusher.
　この構成により、回転防止用溝及び回転防止用突起の剛性向上が図られる。このため、回転防止用溝と回転防止用突起との係合力を高め、一層良好な回転防止機能が得られる。 This configuration improves the rigidity of the anti-rotation groove and anti-rotation protrusion. For this reason, the engagement force between the groove for preventing rotation and the protrusion for preventing rotation is increased, and a better anti-rotation function can be obtained.
　前記ガスケットは、前記ガスケットの基端面に開口する凹部を有し、前記押し子は、前記凹部に挿入された先端部を有し、前記第１リブは、前記凹部の内周面に設けられるとともに周方向に延在し、前記第２リブは、前記押し子の前記先端部の外周面に設けられるとともに周方向に延在していてもよい。 The gasket has a recess opening in a base end surface of the gasket, the pusher has a distal end portion inserted into the recess, and the first rib is provided on an inner peripheral surface of the recess. It extends in the circumferential direction, and the second rib may be provided on the outer peripheral surface of the tip portion of the pusher and extend in the circumferential direction.
　この構成により、第１リブ及び第２リブの剛性向上が図られる。このため、第１リブと第２リブとの係合力を高め、一層良好な離脱防止機能が得られる。 This configuration improves the rigidity of the first rib and the second rib. For this reason, the engagement force of the 1st rib and the 2nd rib is raised, and a further better detachment prevention function is obtained.
　前記ガスケットは、前記ガスケットの基端面に開口する凹部を有し、前記押し子は、前記凹部に挿入された先端部を有し、前記凹部は、前記ガスケットの基端面に開口した第１凹部と、前記第１凹部と同心状に前記第１凹部の先端側に隣接するとともに前記第１凹部よりも小径に形成された第２凹部とを有し、前記回転防止用溝は、前記第２凹部の内周面に設けられるとともに前記ガスケットの軸に沿って延在し、前記回転防止用突起は、前記先端部の外周面に前記第２リブよりも先端側に設けられるとともに前記押し子の軸に沿って延在し、前記第１リブは、前記第１凹部の内周面に設けられるとともに周方向に延在し、前記第２リブは、前記押し子の前記先端部の外周面に設けられるとともに周方向に延在し、前記回転防止用突起の突出端面は、前記第２リブの突出端面よりも径方向内側に位置していてもよい。 The gasket has a recess opening in the base end surface of the gasket, the pusher has a distal end portion inserted into the recess, and the recess has a first recess opening in the base end surface of the gasket. And a second recess formed concentrically with the first recess and adjacent to the distal end side of the first recess and having a smaller diameter than the first recess, and the anti-rotation groove includes the second recess The rotation preventing projection is provided on the outer peripheral surface of the tip end portion on the tip side of the second rib and is provided on the inner peripheral surface of the gasket. The first rib is provided on the inner peripheral surface of the first recess and extends in the circumferential direction, and the second rib is provided on the outer peripheral surface of the tip portion of the pusher. And extending in the circumferential direction, the protrusion of the anti-rotation protrusion The end face may be located radially inward of the projecting end face of the second rib.
　この構成により、回転防止用溝と回転防止用突起との係合力、及び第１リブと第２リブとの係合力が高まり、一層良好な回転防止能力及び離脱防止能力が得られる。また、回転防止用溝と回転防止用突起とからなる回転防止部が、第１リブと第２リブとからなる離脱防止部よりも先端側に設けられ、且つ、回転防止部が離脱防止部よりも径方向内側に設けられため、組立工程において、ガスケットと押し子とを支障なく接続することができる。 With this configuration, the engagement force between the rotation prevention groove and the rotation prevention protrusion and the engagement force between the first rib and the second rib are increased, and a better rotation prevention capability and separation prevention capability can be obtained. An anti-rotation portion comprising an anti-rotation groove and an anti-rotation protrusion is provided on the tip side of the separation preventing portion comprising the first rib and the second rib, and the rotation prevention portion is provided by the separation prevention portion. Is also provided on the inner side in the radial direction, the gasket and the pusher can be connected without hindrance in the assembly process.
　前記回転防止用溝は、前記ガスケットの軸回りに、５～２０°の間隔で複数設けられていてもよい。 A plurality of the rotation preventing grooves may be provided around the gasket axis at intervals of 5 to 20 °.
　このような間隔で回転防止用溝が複数設けられることにより、ガスケットに押し子を装着する際に、回転防止用溝と回転防止用突起との位置を厳密に合わせることなく、回転防止用溝と回転防止用突起とを係合させることができる。 By providing a plurality of anti-rotation grooves at such an interval, the anti-rotation groove and the anti-rotation groove are not closely aligned with each other when the pusher is attached to the gasket. The rotation preventing protrusion can be engaged.
　前記回転防止用突起は、前記押し子の軸回りに複数設けられており、前記回転防止用突起の数は、前記回転防止用溝よりも少なくてもよい。 A plurality of the rotation preventing projections are provided around the axis of the pusher, and the number of the rotation preventing projections may be smaller than that of the rotation preventing grooves.
　この構成により、より簡単に回転防止用溝と回転防止用突起とを係合させることができる。 This configuration makes it possible to more easily engage the anti-rotation groove with the anti-rotation protrusion.
　前記第１リブは、周方向に間隔を置いて複数設けられており、前記第２リブは、周方向に一周延在する環状に形成されていてもよい。 A plurality of the first ribs may be provided at intervals in the circumferential direction, and the second rib may be formed in an annular shape that extends once in the circumferential direction.
　この構成により、ガスケットと押し子との周方向の相対位置に関わらず離脱防止機能を発揮させることができるとともに、離脱防止能力の向上が図られる。 With this configuration, the separation preventing function can be exhibited regardless of the relative position in the circumferential direction between the gasket and the pusher, and the separation preventing ability can be improved.
　前記バレル組立体は、前記押し子がユーザによって押されるシリンジであり、前記バレルと前記ガスケットとにより形成される充填空間には、薬液が充填されていてもよい。 The barrel assembly is a syringe in which the pusher is pushed by a user, and a filling space formed by the barrel and the gasket may be filled with a chemical solution.
　この構成により、押し子を回転させることでガスケットが連動してバレル内で回転することができるため、シリンジの使用前に、ガスケットのバレル内面への固着を簡便に解除することができる。固着解除により、初期摺動抵抗を下げることができる。すなわち、一般に、シリンジの使用前に押し子を押す操作を行う場合があり、その際に、液漏れやそれに伴う汚染の可能性がある。本発明のバレル組立体がシリンジに適用されることにより、上記可能性を低減することができる。 This configuration allows the gasket to be interlocked and rotated in the barrel by rotating the pusher, so that the gasket can be easily released from the barrel inner surface before use of the syringe. By releasing the sticking, the initial sliding resistance can be lowered. That is, in general, there is a case where an operation of pushing the pusher is performed before using the syringe, and there is a possibility of liquid leakage and accompanying contamination. The possibility described above can be reduced by applying the barrel assembly of the present invention to a syringe.
　前記押し子の基端部には、外方に突出する押し子フランジが設けられ、前記押し子フランジの外周部には、指を掛けるための溝部又は突起が設けられていてもよい。 The base end of the pusher may be provided with a pusher flange protruding outward, and the outer periphery of the pusher flange may be provided with a groove or a protrusion for hooking a finger.
　この構成により、押し子の回転操作がしやすい。 This configuration makes it easy to rotate the pusher.
　前記押し子は、前記バレルの基端開口を介して前記バレルに挿入されており、前記バレルの基端部には、外方に突出したフランジ部が設けられ、前記バレル組立体は、前記フランジ部に装着されるように構成された回転補助部材を備え、前記回転補助部材は、内方に突出するとともに前記バレルの前記基端開口に対向する押し子回転用突起を有し、前記押し子には、前記押し子が初期位置にあるときに前記押し子回転用突起よりも基端側で前記押し子回転用突起に対向するとともに、前記押し子の軸に対して傾斜した傾斜部が設けられ、前記押し子が先端方向に前進する際に、前記傾斜部が前記押し子回転用突起に押されることで、前記押し子が回転してもよい。 The pusher is inserted into the barrel through a base end opening of the barrel, and a flange portion projecting outward is provided at a base end portion of the barrel, and the barrel assembly includes the flange A rotation assisting member configured to be mounted on a portion, the rotation assisting member projecting inward and having a pusher rotation projection facing the proximal end opening of the barrel; Is provided with an inclined portion that is opposed to the pusher rotation protrusion on the proximal side of the pusher rotation protrusion when the pusher is in the initial position and is inclined with respect to the pusher axis. When the pusher advances in the distal direction, the pusher may rotate by the inclined portion being pushed by the pusher rotation protrusion.
　この構成により、押し子を先端方向に押す操作を行うことにより、ガスケットを簡単に回転させることができる。このため、ガスケットの固着解除を一層簡便に遂行することができる。 This configuration allows the gasket to be easily rotated by pushing the pusher in the tip direction. For this reason, the sticking release of the gasket can be performed more easily.
　前記押し子は、前記ガスケットを先端方向に押圧可能な押圧部を有し、前記ガスケットは、前記押圧部と対向する位置に設けられた被押圧部を有し、前記シリンジの初期状態で、前記押圧部と前記被押圧部とは、軸方向に離間しており、前記押し子が先端方向に前進する際、前記押圧部は、前記押し子が回転し始めた後に前記ガスケットの前記被押圧部に当接してもよい。 The pusher has a pressing part capable of pressing the gasket in the distal direction, and the gasket has a pressed part provided at a position facing the pressing part, and in the initial state of the syringe, The pressing portion and the pressed portion are spaced apart in the axial direction, and when the pusher moves forward in the distal direction, the pressing portion is the pressed portion of the gasket after the pusher starts to rotate. You may contact.
　この構成により、ガスケットが前進する前にガスケットを確実に回転させることができる。 ∙ With this configuration, the gasket can be reliably rotated before the gasket moves forward.
　また、本発明は、薬液が充填されたバレルと、前記バレル内に摺動可能に配置されたガスケットと、前記ガスケットに接続され、前記ガスケットを先端方向に押圧可能な押し子とを備えたシリンジの使用方法であって、前記ガスケット及び前記押し子の一方には、回転防止用溝が設けられ、前記ガスケット及び前記押し子の他方には、前記回転防止用溝に挿入された回転防止用突起が設けられ、前記回転防止用溝に前記回転防止用突起との係合により、前記ガスケットと前記押し子との相対回転が防止され、前記ガスケットには、径方向に突出した第１リブが設けられ、前記押し子には、径方向に突出するとともに、前記第１リブの先端面に係合し又は前記先端面に対向する第２リブが設けられ、前記第１リブと前記第２リブとの係合により、前記ガスケットからの前記押し子の離脱が防止され、前記使用方法は、前記ガスケットを前進させる前に、前記押し子を回転させることで、前記回転防止用溝と前記回転防止用突起との係合を介して前記バレル内で前記ガスケットを回転させる回転ステップと、前記ガスケットが少なくとも回転し始めた後に前記押し子を前進させることで、前記ガスケットを前記バレル内で前進させる前進ステップと、を含む。 Further, the present invention is a syringe provided with a barrel filled with a chemical, a gasket slidably disposed in the barrel, and a pusher connected to the gasket and capable of pressing the gasket in a distal direction. The one of the gasket and the pusher is provided with a rotation prevention groove, and the other of the gasket and the pusher is provided with a rotation prevention protrusion inserted into the rotation prevention groove. Relative rotation between the gasket and the pusher is prevented by engaging the rotation preventing groove with the rotation preventing projection, and the gasket is provided with a first rib projecting in the radial direction. The pusher is provided with a second rib that protrudes in the radial direction and engages with or faces the tip surface of the first rib, and the first rib and the second rib By engagement Detachment of the pusher from the gasket is prevented, and the method of use is to rotate the pusher before moving the gasket forward, so that the rotation prevention groove and the rotation prevention protrusion are engaged. A rotating step of rotating the gasket in the barrel via a joint, and an advancing step of advancing the gasket in the barrel by advancing the pusher after the gasket starts to rotate at least. .
　この構成により、シリンジの使用前に、ガスケットのバレル内面への固着を簡便に解除することができる。 This configuration makes it possible to easily release the gasket from adhering to the inner surface of the barrel before using the syringe.
　また、本発明は、薬液を生体内に投与するための薬液投与装置であって、上記いずれかのバレル組立体と、前記バレル組立体の前記押し子を先端方向へ前進させる駆動部と、前記バレル組立体及び前記駆動部を収容するハウジングと、を備え、前記バレルは、長軸と短軸とを有するフランジ部が基端部に設けられ、前記押し子は、前記ガスケットに接続された先端部と、前記押し子の外周面に開口するスロットが設けられたロッド部とを有し、前記駆動部は、前記スロットに挿入された送りねじを有し、前記フランジ部の前記短軸と前記ロッド部の前記スロットの開口方向とが略一致している。 The present invention is also a chemical solution administration device for administering a chemical solution into a living body, wherein any of the barrel assemblies described above, a drive unit that advances the pusher of the barrel assembly in the distal direction, A barrel assembly and a housing for accommodating the drive unit, wherein the barrel has a flange portion having a major axis and a minor axis at a proximal end portion, and the pusher is a distal end connected to the gasket And a rod portion provided with a slot opened on the outer peripheral surface of the pusher, and the drive portion has a feed screw inserted into the slot, and the short shaft of the flange portion and the rod The opening direction of the slot of the rod part substantially coincides.
　この構成により、薬液投与装置の組立工程において、バレルと押し子の軸回りの位相を適切な位置に合わせ且つその位置を保持した状態で、バレル組立体をハウジング内の所定位置に容易に配置することが可能となる。このため、バレル組立体をハウジング内に配置する際に、ガスケットと押し子との距離が変わったり、ガスケットを移動させてしまったりすることがなく、液漏れやそれに伴う汚染を防止することができる。 With this configuration, in the assembly process of the drug solution administration device, the barrel assembly is easily arranged at a predetermined position in the housing in a state in which the phase around the axis of the barrel and the pusher is adjusted to an appropriate position and the position is maintained. It becomes possible. Therefore, when the barrel assembly is disposed in the housing, the distance between the gasket and the pusher is not changed, and the gasket is not moved, so that liquid leakage and accompanying contamination can be prevented. .
　また、本発明は、薬液を生体内に投与するための薬液投与装置の組立方法であって、前記薬液投与装置は、長軸と短軸とを有するフランジ部が基端部に設けられ、薬液が充填可能なバレルと、前記バレル内に摺動可能に配置されたガスケットと、前記ガスケットに接続された先端部と、外周面に開口するスロットが設けられたロッド部とを有し、前記ガスケットを先端方向に押圧可能な押し子と、前記スロットに挿入された送りねじを有し、前記押し子を先端方向へ前進させる駆動部と、前記バレル、前記ガスケット及び前記押し子を有するバレル組立体と、前記駆動部とを収容するハウジングと、を備え、前記ガスケット及び前記押し子の一方には、回転防止用溝が設けられ、前記ガスケット及び前記押し子の他方には、前記回転防止用溝に挿入された回転防止用突起が設けられ、前記ガスケットには、前記押し子に向かって径方向に突出した第１リブが設けられ、前記押し子には、前記ガスケットに向かって径方向に突出するとともに、前記第１リブの先端面に係合し又は前記先端面に対向する第２リブが設けられ、前記組立方法は、前記バレル内の所定位置に前記ガスケットを挿入するガスケット挿入ステップと、前記フランジ部の前記短軸と前記ロッド部の前記スロットの開口方向とを略一致させた状態で、前記第１リブと前記第２リブとを係合させるとともに、前記回転防止用溝に前記回転防止用突起を挿入することにより、前記ガスケットと前記押し子とを接続し、前記バレル組立体を得る接続ステップと、前記ロッド部の前記スロットに前記送りねじが挿入されるように前記バレル組立体を前記ハウジング内に配置する配置ステップと、を含む。 The present invention also relates to a method of assembling a chemical solution administration device for administering a chemical solution into a living body, wherein the chemical solution administration device is provided with a flange portion having a major axis and a minor axis at a proximal end portion, A gasket that is slidably disposed in the barrel, a tip portion connected to the gasket, and a rod portion provided with a slot that opens to an outer peripheral surface. A pusher that can push the pusher in the tip direction, a drive unit that has a feed screw inserted in the slot, and advances the pusher in the tip direction, and a barrel assembly that has the barrel, the gasket, and the pusher And a housing for accommodating the drive unit, wherein one of the gasket and the pusher is provided with a rotation preventing groove, and the other of the gasket and the pusher is provided with the rotation preventing groove. An anti-rotation protrusion inserted into the gasket, the gasket is provided with a first rib projecting radially toward the pusher, and the pusher projects radially toward the gasket. In addition, a second rib that engages with or faces the tip surface of the first rib is provided, and the assembly method includes a gasket insertion step of inserting the gasket at a predetermined position in the barrel; The first rib and the second rib are engaged with each other while the minor axis of the flange portion and the opening direction of the slot of the rod portion are substantially aligned, and the rotation preventing groove is rotated. A connecting step of connecting the gasket and the pusher to obtain the barrel assembly by inserting a prevention protrusion, and the feed screw is inserted into the slot of the rod portion The sea urchin said barrel assembly including a placement step of placing in said housing.
　本発明によれば、押し子とガスケットとの相対回転を防止し且つガスケットからの押し子の離脱を防止することが可能となる。 According to the present invention, it is possible to prevent relative rotation between the pusher and the gasket and to prevent the pusher from being detached from the gasket.
本発明の第１実施形態に係るバレル組立体であるシリンジの斜視図である。It is a perspective view of the syringe which is a barrel assembly concerning a 1st embodiment of the present invention. 図１に示したシリンジの断面図である。It is sectional drawing of the syringe shown in FIG. 図１に示したシリンジの要部拡大断面図である。It is a principal part expanded sectional view of the syringe shown in FIG. 図４Ａは、ガスケットの斜視図である。図４Ｂは、ガスケットの断面図である。FIG. 4A is a perspective view of the gasket. FIG. 4B is a cross-sectional view of the gasket. 図３におけるＶ－Ｖ線に沿った断面図である。FIG. 5 is a sectional view taken along line VV in FIG. 3. 押し子の先端側の斜視図である。It is a perspective view of the front end side of a pusher. 本発明の第２実施形態に係るバレル組立体であるシリンジの斜視図である。It is a perspective view of the syringe which is a barrel assembly which concerns on 2nd Embodiment of this invention. 図７に示したシリンジの要部拡大断面図である。It is a principal part expanded sectional view of the syringe shown in FIG. 回転補助部材の斜視図である。It is a perspective view of a rotation auxiliary member. 図１０Ａは、図７に示したシリンジの使用方法の第１の説明図である。図１０Ｂは、図７に示したシリンジの使用方法の第２の説明図である。FIG. 10A is a first explanatory view of a method of using the syringe shown in FIG. FIG. 10B is a second explanatory diagram of a method of using the syringe shown in FIG. 他の構成例に係る回転補助部材の斜視図である。It is a perspective view of the rotation auxiliary member concerning other examples of composition. 本発明の実施形態に係る薬液投与装置の概略図である。It is the schematic of the chemical | medical solution administration apparatus which concerns on embodiment of this invention. 上ハウジングを外した状態の薬液投与装置の斜視図である。It is a perspective view of the chemical | medical solution administration apparatus of the state which removed the upper housing. 薬液投与装置の断面図である。It is sectional drawing of a chemical | medical solution administration apparatus. 薬液投与装置の押し子を下面側から見た斜視図である。It is the perspective view which looked at the pusher of the chemical | medical solution administration apparatus from the lower surface side. 薬液投与装置の組立方法の挿入ステップの説明図である。It is explanatory drawing of the insertion step of the assembly method of a chemical | medical solution administration apparatus. 図１７Ａは、薬液投与装置の組立方法の接続ステップの第２の説明図（斜視図）である。図１７Ｂは、薬液投与装置の組立方法の接続ステップの第２の説明図（断面図）である。FIG. 17A is a second explanatory diagram (perspective view) of a connection step in the method of assembling the drug solution administration device. FIG. 17B is a second explanatory diagram (cross-sectional view) of a connection step in the method of assembling the drug solution administration device. 薬液投与装置の組立方法の第３の説明図である。It is a 3rd explanatory drawing of the assembly method of a chemical | medical solution administration apparatus.
　以下、本発明の複数の実施形態を挙げ、添付の図面を参照しながら説明する。なお、実施形態間において、同一又は同様な要素には同一の参照符号を付し、重複した説明を省略する。 Hereinafter, a plurality of embodiments of the present invention will be given and described with reference to the accompanying drawings. Note that, in the embodiments, the same or similar elements are denoted by the same reference numerals, and redundant description is omitted.
　図１及び図２に示す本発明の第１実施形態に係るバレル組立体１０Ａは、中空状のバレル１２と、バレル１２内に摺動可能に配置されたガスケット１４と、ガスケット１４に接続され、ガスケット１４を先端方向に押圧可能な押し子１６とを備える。このバレル組立体１０Ａは、押し子１６がユーザによって押されるシリンジ１１Ａである。特に、このシリンジ１１Ａは、製品提供時点でバレル１２とガスケット１４とにより形成される充填空間１３に予め薬液Ｍが充填されたプレフィルドシリンジである。 The barrel assembly 10A according to the first embodiment of the present invention shown in FIGS. 1 and 2 is connected to the hollow barrel 12, the gasket 14 slidably disposed in the barrel 12, and the gasket 14. A pusher 16 capable of pressing the gasket 14 in the distal direction is provided. This barrel assembly 10A is a syringe 11A in which the pusher 16 is pushed by the user. In particular, the syringe 11A is a prefilled syringe in which a drug solution M is filled in advance in a filling space 13 formed by the barrel 12 and the gasket 14 at the time of product provision.
　バレル１２は、略円筒形状をなすとともに基端に基端開口部が形成された胴部１２ａと、胴部１２ａの先端部から縮径した肩部１２ｂと、胴部１２ａの先端に設けられたノズル１２ｃと、胴部１２ａの基端から径方向外側に突出したフランジ部１２ｄとを有する。ノズル１２ｃは、胴部１２ａの先端中心部から胴部１２ａに対して縮径して先端方向に延出している。フランジ部１２ｄは、短軸と長軸とを有する非円形形状に形成されている。 The barrel 12 has a substantially cylindrical shape and a trunk portion 12a having a proximal end opening formed at the proximal end, a shoulder portion 12b having a diameter reduced from the distal end portion of the trunk portion 12a, and a distal end of the barrel portion 12a. It has a nozzle 12c and a flange portion 12d that protrudes radially outward from the base end of the body portion 12a. The nozzle 12c has a diameter reduced from the center of the front end of the body 12a with respect to the body 12a and extends in the front end direction. The flange portion 12d is formed in a non-circular shape having a short axis and a long axis.
　ガスケット１４は、胴部１２ａの基端で開口する基端開口部を介してバレル１２内に挿入されている。ガスケット１４によってバレル１２の基端側が液密に封止されている。ガスケット１４は、例えばゴム材等の弾性材料により構成されている。ガスケット１４は、その外周部が胴部１２ａの内周面に液密に接するとともに、胴部１２ａ内に摺動可能に配置されている。 The gasket 14 is inserted into the barrel 12 through a proximal end opening that opens at the proximal end of the body 12a. The proximal end side of the barrel 12 is liquid-tightly sealed by the gasket 14. The gasket 14 is made of an elastic material such as a rubber material. The outer periphery of the gasket 14 is in liquid-tight contact with the inner peripheral surface of the body 12a and is slidably disposed in the body 12a.
　図３～図４Ｂに示すように、ガスケット１４には、回転防止用溝２０と、押し子１６に向かって径方向に突出した第１リブ３０とが設けられている。具体的に、ガスケット１４は、ガスケット１４の基端面１４ａに開口する凹部２２を有する。凹部２２は、ガスケット１４の基端面１４ａに開口した第１凹部２２ａと、第１凹部２２ａと同心状に第１凹部２２ａの先端側に隣接するとともに第１凹部２２ａよりも小径に形成された第２凹部２２ｂとを有する。第１凹部２２ａ及び第２凹部２２ｂのガスケット１４の軸に垂直な断面形状は、略円形である。 As shown in FIGS. 3 to 4B, the gasket 14 is provided with a rotation preventing groove 20 and a first rib 30 projecting radially toward the pusher 16. Specifically, the gasket 14 has a recess 22 that opens to the proximal end surface 14 a of the gasket 14. The recess 22 has a first recess 22a that is open on the base end surface 14a of the gasket 14, a concentric shape with the first recess 22a, adjacent to the distal end side of the first recess 22a, and a smaller diameter than the first recess 22a. 2 recesses 22b. The cross-sectional shape perpendicular | vertical to the axis | shaft of the gasket 14 of the 1st recessed part 22a and the 2nd recessed part 22b is substantially circular.
　図４Ａ及び図４Ｂに示すように、回転防止用溝２０は、第２凹部２２ｂの内周面に設けられるとともにガスケット１４の軸に沿って延在する。回転防止用溝２０は、ガスケット１４の軸を囲むように周方向に等間隔に複数設けられている。複数の回転防止用溝２０は、第２凹部２２ｂの内周面において環状凹凸構造を構成している。回転防止用溝２０は、第１リブ３０よりも径方向内側に設けられている。回転防止用溝２０が複数設けられる場合、回転防止用溝２０は、ガスケット１４の軸回りに、例えば、５～２０°の間隔で設けられ、好ましくは、５～１０°の間隔で設けられる。なお、回転防止用溝２０の間隔とは、互いに隣接する回転防止用溝２０の周方向中央位置同士の角度をいう。 4A and 4B, the rotation preventing groove 20 is provided on the inner peripheral surface of the second recess 22b and extends along the axis of the gasket 14. A plurality of anti-rotation grooves 20 are provided at equal intervals in the circumferential direction so as to surround the shaft of the gasket 14. The plurality of anti-rotation grooves 20 form an annular concavo-convex structure on the inner peripheral surface of the second recess 22b. The rotation preventing groove 20 is provided on the radially inner side with respect to the first rib 30. When a plurality of rotation preventing grooves 20 are provided, the rotation preventing grooves 20 are provided around the axis of the gasket 14, for example, at intervals of 5 to 20 °, and preferably at intervals of 5 to 10 °. In addition, the space | interval of the groove | channel 20 for rotation prevention means the angle of the circumferential direction center position of the groove | channel 20 for rotation prevention adjacent to each other.
　第１リブ３０は、第１凹部２２ａの内周面に設けられるとともに周方向に延在する。第１リブ３０は、周方向に間隔を置いて複数（図示例では周方向に等間隔に４つ）設けられている。 The first rib 30 is provided on the inner peripheral surface of the first recess 22a and extends in the circumferential direction. A plurality of first ribs 30 are provided at intervals in the circumferential direction (four in the illustrated example at equal intervals in the circumferential direction).
　ガスケット１４の基端部には、周方向に間隔を置いて複数の凸部１４ｂが設けられている。複数の凸部１４ｂは、ガスケット１４の基端面１４ａから基端方向に突出している。ガスケット１４の基端部には、周方向に間隔を置いて複数の切欠き溝１４ｃが設けられている。複数の切欠き溝１４ｃは、ガスケット１４の基端面１４ａ及び凹部２２（第１凹部２２ａ）の内周面に開口している。 A plurality of convex portions 14b are provided at the base end portion of the gasket 14 at intervals in the circumferential direction. The plurality of convex portions 14 b protrude from the base end surface 14 a of the gasket 14 in the base end direction. A plurality of notch grooves 14 c are provided at the base end portion of the gasket 14 at intervals in the circumferential direction. The plurality of cutout grooves 14c are open on the base end surface 14a of the gasket 14 and the inner peripheral surface of the recess 22 (first recess 22a).
　図２に示すように、押し子１６は、押し子１６の主要部（胴体）を構成する軸部２４と、軸部２４の先端から先端方向に突出するとともにガスケット１４に接続された先端部２６と、軸部２４の基端から径方向外側に突出した押し子フランジ２８とを有する。図２に示すように、軸部２４は、押し子１６の軸に沿って延在するとともに押し子１６の軸から放射状に突出した４つの板状リブ２４ａを有する。４つの板状リブ２４ａにより、押し子１６の軸に垂直な面での軸部２４の断面形状は、クロス形状に形成されている。 As shown in FIG. 2, the pusher 16 includes a shaft portion 24 that constitutes a main portion (body) of the pusher 16, and a distal end portion 26 that protrudes from the distal end of the shaft portion 24 in the distal direction and is connected to the gasket 14. And a pusher flange 28 protruding outward in the radial direction from the base end of the shaft portion 24. As shown in FIG. 2, the shaft portion 24 has four plate-like ribs 24 a that extend along the axis of the pusher 16 and project radially from the axis of the pusher 16. Due to the four plate-like ribs 24a, the cross-sectional shape of the shaft portion 24 in a plane perpendicular to the axis of the pusher 16 is formed in a cross shape.
　図３に示すように、先端部２６は、ガスケット１４の凹部２２に挿入されている。先端部２６には、先端方向に開口した先端凹部２７が設けられている。このため、先端部２６は、中空状に構成されている。 As shown in FIG. 3, the tip end portion 26 is inserted into the recess 22 of the gasket 14. The distal end portion 26 is provided with a distal end concave portion 27 that opens in the distal direction. For this reason, the front-end | tip part 26 is comprised by the hollow shape.
　図１に示すように、押し子フランジ２８の外周部には、ユーザの指を掛けるための溝部２８ａが設けられている。溝部２８ａは、周方向に間隔を置いて複数設けられている。溝部２８ａは１つだけ設けられてもよい。押し子フランジ２８の外周部には、溝部２８ａに代えて、あるいは溝部２８ａに加えて、ユーザの指を掛けるための突起が設けられてもよい。この場合、指掛け用の突起は、１つだけ設けられてもよく、あるいは周方向に間隔を置いて複数設けられてもよい。 As shown in FIG. 1, a groove portion 28 a for hooking a user's finger is provided on the outer peripheral portion of the pusher flange 28. A plurality of grooves 28a are provided at intervals in the circumferential direction. Only one groove 28a may be provided. A protrusion for hooking a user's finger may be provided on the outer peripheral portion of the pusher flange 28 in place of or in addition to the groove portion 28a. In this case, only one finger hooking projection may be provided, or a plurality of projections may be provided at intervals in the circumferential direction.
　図３及び図６に示すように、押し子１６には、回転防止用溝２０に挿入された回転防止用突起２１と、ガスケット１４に向かって径方向外側に突出した第２リブ３１とが設けられている。回転防止用突起２１は、押し子１６の先端部２６の外周面に設けられるとともに押し子１６の軸に沿って延在している。回転防止用突起２１は、第２リブ３１よりも先端側に設けられている。図５及び図６に示すように、回転防止用突起２１は、周方向に間隔を置いて複数（図示例では４つ）設けられている。回転防止用突起２１の突出端面は、第２リブ３１の突出端面よりも径方向内側に位置している。回転防止用溝２０と回転防止用突起２１との係合により、ガスケット１４と押し子１６との相対回転が防止される。 As shown in FIGS. 3 and 6, the pusher 16 is provided with an anti-rotation protrusion 21 inserted into the anti-rotation groove 20 and a second rib 31 protruding radially outward toward the gasket 14. It has been. The rotation preventing projection 21 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16 and extends along the axis of the pusher 16. The rotation preventing projection 21 is provided on the tip side of the second rib 31. As shown in FIGS. 5 and 6, a plurality (four in the illustrated example) of anti-rotation protrusions 21 are provided at intervals in the circumferential direction. The protruding end surface of the rotation preventing protrusion 21 is located on the radially inner side than the protruding end surface of the second rib 31. Relative rotation between the gasket 14 and the pusher 16 is prevented by the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21.
　図３に示すように、第２リブ３１は、押し子１６の先端部２６の外周面に設けられるとともに周方向に延在し、第１リブ３０の先端面に係合している。第２リブ３１は、第１リブ３０の先端面から先端方向に離間し、当該先端面に対向していてもよい。第２リブ３１は、周方向に一周延在する環状に形成されている。なお、第１リブ３０は、周方向に一周延在する環状に形成され、第２リブ３１は、周方向に間隔を置いて設けられた複数のリブにより構成されてもよい。第１リブ３０と第２リブ３１との係合により、ガスケット１４からの押し子１６の離脱が防止される。 As shown in FIG. 3, the second rib 31 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16, extends in the circumferential direction, and engages with the distal end surface of the first rib 30. The second rib 31 may be spaced apart from the tip surface of the first rib 30 in the tip direction and may face the tip surface. The 2nd rib 31 is formed in the cyclic | annular form extended 1 round in the circumferential direction. In addition, the 1st rib 30 may be formed in the cyclic | annular form extended 1 round in the circumferential direction, and the 2nd rib 31 may be comprised by the some rib provided at intervals in the circumferential direction. The engagement between the first rib 30 and the second rib 31 prevents the pusher 16 from being detached from the gasket 14.
　なお、上述した構成に代えて、押し子１６の先端部２６の外周面に回転防止用溝が設けられ、ガスケット１４の凹部２２の内周面に当該回転防止用溝が挿入される回転防止用突起が設けられてもよい。あるいは、上述した構成に代えて、ガスケット１４の基端面１４ａに回転防止用溝が設けられ、軸部２４の先端面２４ｂに当該回転防止用溝に挿入される回転防止用突起が設けられてもよい。あるいは、軸部２４の先端面２４ｂに回転防止用溝が設けられ、ガスケット１４の基端面１４ａに当該回転防止用溝に挿入される回転防止用突起が設けられてもよい。 Instead of the configuration described above, a rotation prevention groove is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16, and the rotation prevention groove is inserted into the inner peripheral surface of the recess 22 of the gasket 14. A protrusion may be provided. Alternatively, instead of the above-described configuration, a rotation preventing groove may be provided on the base end surface 14a of the gasket 14, and a rotation preventing projection inserted into the rotation preventing groove may be provided on the distal end surface 24b of the shaft portion 24. Good. Alternatively, a rotation prevention groove may be provided on the distal end surface 24b of the shaft portion 24, and a rotation prevention protrusion inserted into the rotation prevention groove may be provided on the proximal end surface 14a of the gasket 14.
　上述した構成に代えて、ガスケット１４に径方向外側に突出した第１リブが設けられ、押し子１６に径方向内側に突出した第２リブが設けられ、このような第１リブと第２リブとの係合により、ガスケット１４からの押し子１６の離脱が防止されてもよい。 Instead of the above-described configuration, the gasket 14 is provided with a first rib projecting radially outward, and the pusher 16 is provided with a second rib projecting radially inward. Such first rib and second rib Detachment of the pusher 16 from the gasket 14 may be prevented.
　このように構成される本実施形態に係るバレル組立体１０Ａは、以下の効果を奏する。 The barrel assembly 10A according to this embodiment configured as described above has the following effects.
　バレル組立体１０Ａによれば、回転防止用溝２０と回転防止用突起２１との係合により、ガスケット１４と押し子１６との相対回転が防止され、第１リブ３０と第２リブ３１との係合により、ガスケット１４からの押し子１６の離脱が防止される。このため、押し子１６とガスケット１４との相対回転を防止し且つガスケット１４からの押し子１６の離脱を防止することが可能となる。 According to the barrel assembly 10 </ b> A, the relative rotation between the gasket 14 and the pusher 16 is prevented by the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21, and the first rib 30 and the second rib 31 are separated from each other. The engagement prevents the pusher 16 from being detached from the gasket 14. For this reason, relative rotation between the pusher 16 and the gasket 14 can be prevented, and separation of the pusher 16 from the gasket 14 can be prevented.
　特に、バレル組立体１０Ａは、押し子１６がユーザによって押されるシリンジ１１Ａであり、バレル１２とガスケット１４とにより形成される充填空間１３には、薬液Ｍが充填されている。このため、シリンジ１１Ａを用いて、次の使用方法を実施することができる。 Particularly, the barrel assembly 10A is a syringe 11A in which the pusher 16 is pushed by the user, and the filling space 13 formed by the barrel 12 and the gasket 14 is filled with the chemical solution M. For this reason, the following usage method can be implemented using the syringe 11A.
　ガスケット１４を前進させる前に、押し子１６を回転させることで、回転防止用溝２０と回転防止用突起２１との係合を介してバレル１２内でガスケット１４を回転させる（回転ステップ）。回転ステップにより、ガスケット１４のバレル１２内面への固着が解除される。次に、ガスケット１４が少なくとも回転し始めた後に押し子１６を前進させることで、ガスケット１４をバレル１２内で前進させる（前進ステップ）。前進ステップの実施タイミングは、回転ステップによって押し子１６の回転が開始した以降であればよい。このため、ユーザは押し子１６を把持して回転させた後に、押し子１６を先端方向に押せばよい。なお、押し子１６は、シリンジ１１Ａを使用する直前にガスケット１４に接続されてもよい。 Before the gasket 14 is advanced, the pusher 16 is rotated to rotate the gasket 14 in the barrel 12 through the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21 (rotation step). By the rotation step, the gasket 14 is released from the inner surface of the barrel 12. Next, the gasket 14 is advanced in the barrel 12 by advancing the pusher 16 after at least the gasket 14 starts to rotate (advancing step). The advance timing of the advance step may be after the start of the rotation of the pusher 16 by the rotation step. For this reason, the user only has to push the pusher 16 in the distal direction after gripping and rotating the pusher 16. The pusher 16 may be connected to the gasket 14 immediately before using the syringe 11A.
　このように、シリンジ１１Ａによれば、押し子１６を回転させることでガスケット１４が連動してバレル１２内で回転することができるため、シリンジ１１Ａの使用前に、ガスケット１４のバレル１２内面への固着を簡便に解除することができる。固着解除により、ガスケット１４の初期摺動抵抗を下げることができる。すなわち、一般に、シリンジの使用前に押し子を押す操作を行う場合があり、その際に、液漏れやそれに伴う汚染の可能性がある。バレル組立体１０Ａがシリンジ１１Ａに適用されることにより、上記可能性を低減することができる。 As described above, according to the syringe 11A, the gasket 14 can be rotated in the barrel 12 by rotating the pusher 16, so that the gasket 14 can be applied to the inner surface of the barrel 12 before the syringe 11A is used. Fixing can be easily released. By releasing the sticking, the initial sliding resistance of the gasket 14 can be lowered. That is, in general, there is a case where an operation of pushing the pusher is performed before using the syringe, and there is a possibility of liquid leakage and accompanying contamination. By applying the barrel assembly 10A to the syringe 11A, the above possibility can be reduced.
　回転防止用溝２０は、ガスケット１４に設けられ、回転防止用突起２１は、押し子１６に設けられている。この構成により、ガスケット１４と押し子１６との回転防止構造を簡単に設けることができる。 The rotation prevention groove 20 is provided in the gasket 14, and the rotation prevention protrusion 21 is provided in the pusher 16. With this configuration, a structure for preventing rotation between the gasket 14 and the pusher 16 can be easily provided.
　ガスケット１４は、ガスケット１４の基端面１４ａに開口する凹部２２を有し、押し子１６は、凹部２２に挿入された先端部２６を有する。回転防止用溝２０は、凹部２２の内周面に設けられるとともにガスケット１４の軸に沿って延在する。そして、回転防止用突起２１は、押し子１６の先端部２６の外周面に設けられるとともに押し子１６の軸に沿って延在している。この構成により、回転防止用溝２０及び回転防止用突起２１の剛性向上が図られる。このため、回転防止用溝２０と回転防止用突起２１との係合力を高め、一層良好な回転防止能力が得られる。 The gasket 14 has a recess 22 that opens to the base end surface 14 a of the gasket 14, and the pusher 16 has a distal end portion 26 that is inserted into the recess 22. The rotation preventing groove 20 is provided on the inner peripheral surface of the recess 22 and extends along the axis of the gasket 14. The rotation preventing projection 21 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16 and extends along the axis of the pusher 16. With this configuration, the rigidity of the rotation preventing groove 20 and the rotation preventing projection 21 can be improved. For this reason, the engagement force between the rotation preventing groove 20 and the rotation preventing projection 21 is increased, and a better rotation preventing ability is obtained.
　第１リブ３０は、凹部２２の内周面に設けられるとともに周方向に延在し、第２リブ３１は、押し子１６の先端部２６の外周面に設けられるとともに周方向に延在している。この構成により、第１リブ３０及び第２リブ３１の剛性向上が図られる。このため、第１リブ３０と第２リブ３１との係合力を高め、一層良好な離脱防止能力が得られる。 The first rib 30 is provided on the inner peripheral surface of the recess 22 and extends in the circumferential direction, and the second rib 31 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16 and extends in the circumferential direction. Yes. With this configuration, the rigidity of the first rib 30 and the second rib 31 can be improved. For this reason, the engagement force of the 1st rib 30 and the 2nd rib 31 is raised, and a further better detachment prevention capability is obtained.
　凹部２２は、ガスケット１４の基端面１４ａに開口した第１凹部２２ａと、第１凹部２２ａと同心状に第１凹部２２ａの先端側に隣接するとともに第１凹部２２ａよりも小径に形成された第２凹部２２ｂとを有する。回転防止用溝２０は第２凹部２２ｂの内周面に設けられ、回転防止用突起２１は、先端部２６の外周面に第２リブ３１よりも先端側に設けられている。第１リブ３０は、第１凹部２２ａの内周面に設けられ、第２リブ３１は押し子１６の先端部２６の外周面に設けられている。そして、回転防止用突起２１の突出端面は、第２リブ３１の突出端面よりも径方向内側に位置している。 The recess 22 has a first recess 22a that is open on the base end surface 14a of the gasket 14, a concentric shape with the first recess 22a, adjacent to the distal end side of the first recess 22a, and a smaller diameter than the first recess 22a. 2 recesses 22b. The anti-rotation groove 20 is provided on the inner peripheral surface of the second recess 22 b, and the anti-rotation protrusion 21 is provided on the outer peripheral surface of the front end portion 26 on the front end side of the second rib 31. The first rib 30 is provided on the inner peripheral surface of the first recess 22 a, and the second rib 31 is provided on the outer peripheral surface of the distal end portion 26 of the pusher 16. The protruding end surface of the rotation preventing protrusion 21 is located on the radially inner side with respect to the protruding end surface of the second rib 31.
　この構成により、回転防止用溝２０と回転防止用突起２１とからなる回転防止部が、第１リブ３０と第２リブ３１とからなる離脱防止部よりも先端側に設けられ、且つ、回転防止部が離脱防止部よりも径方向内側に設けられる。この構成により、ガスケット１４と押し子１６とを支障なく接続することができる。すなわち、ガスケット１４の凹部２２に押し子１６の先端部２６を挿入する際に、押し子１６の先端部２６に設けられた回転防止用突起２１は、ガスケット１４の凹部２２の内周面に設けられた第１リブ３０の内側を通過して、回転防止用溝２０に支障なく挿入される。 With this configuration, the anti-rotation portion composed of the anti-rotation groove 20 and the anti-rotation protrusion 21 is provided on the tip side of the anti-detachment portion composed of the first rib 30 and the second rib 31, and the anti-rotation portion is provided. The portion is provided on the radially inner side than the separation preventing portion. With this configuration, the gasket 14 and the pusher 16 can be connected without hindrance. That is, when the distal end portion 26 of the pusher 16 is inserted into the concave portion 22 of the gasket 14, the rotation prevention protrusion 21 provided on the distal end portion 26 of the pusher 16 is provided on the inner peripheral surface of the concave portion 22 of the gasket 14. It passes through the inside of the formed first rib 30 and is inserted into the rotation preventing groove 20 without any trouble.
　回転防止用溝２０は、ガスケット１４の軸回りに、５～２０°の間隔で複数設けられている。このような間隔で回転防止用溝２０が複数設けられることにより、ガスケット１４に押し子１６を装着する際に、回転防止用溝２０と回転防止用突起２１との位置を厳密に合わせることなく、回転防止用溝２０と回転防止用突起２１とを係合させることができる。 A plurality of anti-rotation grooves 20 are provided around the axis of the gasket 14 at intervals of 5 to 20 °. By providing a plurality of anti-rotation grooves 20 at such intervals, when the pusher 16 is mounted on the gasket 14, the positions of the anti-rotation grooves 20 and the anti-rotation protrusions 21 are not strictly aligned, The rotation preventing groove 20 and the rotation preventing projection 21 can be engaged with each other.
　回転防止用突起２１は、押し子１６の軸回りに複数設けられており、回転防止用突起２１の数は、回転防止用溝２０よりも少ない。この構成により、より簡単に回転防止用溝２０と回転防止用突起２１とを係合させることができる。 A plurality of rotation prevention protrusions 21 are provided around the axis of the pusher 16, and the number of rotation prevention protrusions 21 is smaller than that of the rotation prevention grooves 20. With this configuration, the rotation prevention groove 20 and the rotation prevention protrusion 21 can be more easily engaged.
　第１リブ３０は、周方向に間隔を置いて複数設けられており、第２リブ３１は、周方向に一周延在する環状に形成されている。この構成により、ガスケット１４と押し子１６との周方向の相対位置に関わらず離脱防止機能を発揮させることができるとともに、離脱防止能力の向上が図られる。 A plurality of first ribs 30 are provided at intervals in the circumferential direction, and the second ribs 31 are formed in an annular shape that extends once in the circumferential direction. With this configuration, the separation preventing function can be exhibited regardless of the relative positions of the gasket 14 and the pusher 16 in the circumferential direction, and the separation preventing ability can be improved.
　押し子１６の基端部には、外方に突出する押し子フランジ２８が設けられ、押し子フランジ２８の外周部には、指を掛けるための溝部２８ａ又は突起が設けられている。この構成により、押し子１６の回転操作がしやすい。 A pusher flange 28 that protrudes outward is provided at the proximal end of the pusher 16, and a groove 28 a or a protrusion for hooking a finger is provided on the outer periphery of the pusher flange 28. With this configuration, the pusher 16 can be easily rotated.
　図７に示す本発明の第２実施形態に係るバレル組立体１０Ｂは、上述したバレル組立体１０Ａと同様に、バレル１２内に薬液Ｍが充填され、ユーザによって押し子１６ａが押されることで薬液Ｍを押し出すシリンジ１１Ｂとして構成されている。 As in the barrel assembly 10A described above, the barrel assembly 10B according to the second embodiment of the present invention shown in FIG. 7 is filled with the chemical solution M in the barrel 12, and the pusher 16a is pushed by the user so that the chemical solution is obtained. It is configured as a syringe 11B that pushes out M.
　シリンジ１１Ｂにおいて、バレル１２に回転補助部材３６が装着されている。回転補助部材３６は、内方に突出するとともにバレル１２の基端開口に対向する押し子回転用突起３８を有する。図９に示すように、回転補助部材３６は、基部４０ａと当該基部４０ａから延出した一対のアーム部４０ｂとを有するＵ字状のベースプレート４０と、ベースプレート４０の基部４０ａに設けられた第１係合ツメ４２と、ベースプレート４０の一対のアーム部４０ｂの自由端側に設けられた２つの第２係合ツメ４４とを備える。図７及び図８において、第１係合ツメ４２が、バレル１２のフランジ部１２ｄの短軸方向の一端側の縁部に係合し、第２係合ツメ４４が、フランジ部１２ｄの短軸方向の他端側の縁部に係合している。押し子回転用突起３８は、基部４０ａから内側に突出している。 In the syringe 11B, the rotation auxiliary member 36 is attached to the barrel 12. The rotation assisting member 36 has a pusher rotation protrusion 38 that protrudes inward and faces the proximal end opening of the barrel 12. As shown in FIG. 9, the rotation assisting member 36 includes a U-shaped base plate 40 having a base portion 40a and a pair of arm portions 40b extending from the base portion 40a, and a first portion provided on the base portion 40a of the base plate 40. An engagement claw 42 and two second engagement claws 44 provided on the free end side of the pair of arm portions 40b of the base plate 40 are provided. 7 and 8, the first engagement claw 42 engages with the edge on one end side in the short axis direction of the flange portion 12d of the barrel 12, and the second engagement claw 44 has the short axis of the flange portion 12d. It is engaged with the edge on the other end side in the direction. The pusher rotation protrusion 38 protrudes inward from the base portion 40a.
　図７に示すように、押し子１６ａの軸部２４には、回転用ガイド４６が設けられている。回転用ガイド４６は、軸部２４の板状リブ２４ａの表面から膨出するように設けられている。具体的に、回転用ガイド４６は、押し子１６ａの軸に対して傾斜した傾斜部４８（傾斜面）を有する。傾斜部４８は、基端方向に向かって板状リブ２４ａの表面からの距離が大きくなるように傾斜している。 As shown in FIG. 7, a rotation guide 46 is provided on the shaft portion 24 of the pusher 16a. The rotation guide 46 is provided so as to bulge from the surface of the plate-like rib 24 a of the shaft portion 24. Specifically, the rotation guide 46 has an inclined portion 48 (inclined surface) inclined with respect to the axis of the pusher 16a. The inclined portion 48 is inclined so that the distance from the surface of the plate-like rib 24a increases in the proximal direction.
　傾斜部４８は、押し子１６ａが初期位置にあるときに押し子回転用突起３８よりも基端側で押し子回転用突起３８に対向する。押し子１６が初期位置にあるとき、傾斜部４８は、押し子回転用突起３８と接触していてもよく、接触していなくてもよい。押し子１６ａが初期位置にあるときに傾斜部４８が押し子回転用突起３８と接触していない場合には、傾斜部４８は押し子回転用突起３８の近傍に位置しているのがよい。図１に示した押し子フランジ２８と異なり、図７において軸部２４の基端部に設けられた押し子フランジ２９には指掛け用の溝は設けられていない。 The inclined portion 48 is opposed to the pusher rotation protrusion 38 on the proximal side with respect to the pusher rotation protrusion 38 when the pusher 16a is in the initial position. When the pusher 16 is in the initial position, the inclined portion 48 may or may not be in contact with the pusher rotation protrusion 38. If the inclined portion 48 is not in contact with the pusher rotation protrusion 38 when the pusher 16a is in the initial position, the inclined portion 48 is preferably located in the vicinity of the pusher rotation protrusion 38. Unlike the pusher flange 28 shown in FIG. 1, the pusher flange 29 provided at the base end portion of the shaft portion 24 in FIG.
　図８に示すように、押し子１６ａは、ガスケット１４Ａを先端方向に押圧可能な押圧部５０を有する。押圧部５０は、軸部２４の先端面２４ｂにより構成されている。ガスケット１４Ａは、押圧部５０と対向する位置に設けられた被押圧部５２を有する。被押圧部５２は、ガスケット１４Ａの基端部（基端面１４ａ及び凸部１４ｂ）により構成されている。シリンジ１１Ｂの初期状態で、押圧部５０と被押圧部５２とは、軸方向に離間している。 As shown in FIG. 8, the pusher 16a has a pressing portion 50 capable of pressing the gasket 14A in the distal direction. The pressing part 50 is configured by a tip surface 24 b of the shaft part 24. The gasket 14 </ b> A has a pressed portion 52 provided at a position facing the pressing portion 50. The pressed portion 52 is configured by a base end portion (base end surface 14a and convex portion 14b) of the gasket 14A. In the initial state of the syringe 11B, the pressing portion 50 and the pressed portion 52 are separated in the axial direction.
　ガスケット１４Ａは、軸方向に互いに隣接した第１凹部２３ａ及び第２凹部２３ｂを有する凹部２３を備える。当該第１凹部２３ａ及び第２凹部２３ｂはそれぞれ上述したガスケット１４の第１凹部２２ａ及び第２凹部２２ｂよりも軸方向に深く形成されている。第２凹部２３ｂの内周面に設けられた回転防止用溝２０ａは、ガスケット１４の回転防止用溝２０よりも軸方向に長く形成されている。凹部２３に挿入された押し子１６ａの先端部２６ａは、上述した押し子１６の先端部２６よりも軸方向に長く構成されている。シリンジ１１Ｂの初期状態で、押し子１６ａの先端部２６ａの先端面と、ガスケット１４Ａの凹部２３の底面２３ｃとは、押圧部５０と被押圧部５２との軸方向の離間距離よりも大きい距離で、軸方向に離間している。 The gasket 14A includes a recess 23 having a first recess 23a and a second recess 23b adjacent to each other in the axial direction. The first recess 23a and the second recess 23b are respectively formed deeper in the axial direction than the first recess 22a and the second recess 22b of the gasket 14 described above. The anti-rotation groove 20 a provided on the inner peripheral surface of the second recess 23 b is formed longer in the axial direction than the anti-rotation groove 20 of the gasket 14. The distal end portion 26a of the pusher 16a inserted into the recess 23 is configured to be longer in the axial direction than the distal end portion 26 of the pusher 16 described above. In the initial state of the syringe 11B, the distal end surface of the distal end portion 26a of the pusher 16a and the bottom surface 23c of the concave portion 23 of the gasket 14A are larger than the axial separation distance between the pressing portion 50 and the pressed portion 52. Are spaced apart in the axial direction.
　なお、押圧部５０及び被押圧部５２は、上記の組合せに限らず、例えば、押し子１６ａの先端部２６ａの先端面が押圧部を構成し、ガスケット１４Ａの凹部２３の底面２３ｃ（第２凹部２３ｂの底面）が被押圧部を構成してもよい。 Note that the pressing portion 50 and the pressed portion 52 are not limited to the above combination. For example, the tip surface of the tip portion 26a of the pusher 16a forms a pressing portion, and the bottom surface 23c (second recess portion) of the recess 23 of the gasket 14A. The bottom surface of 23b may constitute the pressed part.
　上記のように構成されたシリンジ１１Ｂによれば、押し子１６ａが先端方向に前進する際に、傾斜部４８が押し子回転用突起３８に押されることで、押し子１６ａが回転する。すなわち、図１０Ａのように、ユーザが押し子１６ａを先端方向に押すことにより、押し子１６ａがバレル１２に対して前進し始めると、傾斜部４８も一緒に前進する。その際、押し子回転用突起３８と傾斜部４８との作用により、押し子１６ａが前進する力の一部が、押し子１６ａを回転させる力へと変換される。すなわち、押し子１６ａの前進に伴って、押し子回転用突起３８が傾斜部４８を押し子１６ａの周方向へと押圧し、これにより押し子１６ａが回転する。このため、押し子１６ａに対して回転不可能に接続されたガスケット１４Ａも回転する。これにより、バレル１２の内面に対するガスケット１４Ａの固着が解除される。押し子１６ａの前進に伴って、傾斜部４８が押し子回転用突起３８を先端方向に通過すると、図１０Ｂのように、押し子１６ａの回転は停止する。 According to the syringe 11B configured as described above, the pusher 16a is rotated by the inclined portion 48 being pushed by the pusher rotation protrusion 38 when the pusher 16a moves forward in the distal direction. That is, as shown in FIG. 10A, when the user pushes the pusher 16a in the distal direction, the pusher 16a starts to move forward with respect to the barrel 12, and the inclined portion 48 also moves forward. At this time, due to the action of the pusher rotation projection 38 and the inclined portion 48, a part of the force that the pusher 16 a moves forward is converted into a force that rotates the pusher 16 a. That is, as the pusher 16a moves forward, the pusher rotation projection 38 presses the inclined portion 48 in the circumferential direction of the pusher 16a, thereby rotating the pusher 16a. For this reason, the gasket 14A that is non-rotatably connected to the pusher 16a also rotates. Thereby, adhesion of gasket 14A to the inner surface of barrel 12 is released. When the inclined portion 48 passes through the pusher rotation projection 38 in the distal direction as the pusher 16a moves forward, the rotation of the pusher 16a stops as shown in FIG. 10B.
　このように、シリンジ１１Ｂによれば、押し子１６ａを先端方向に押す操作を行うことにより、ガスケット１４Ａを簡単に回転させることができる。このため、シリンジ１１Ｂの使用前に、ガスケット１４Ａの固着解除を一層簡便に遂行することができる。 Thus, according to the syringe 11B, the gasket 14A can be easily rotated by performing an operation of pushing the pusher 16a in the distal direction. For this reason, before use of the syringe 11B, the sticking release of the gasket 14A can be more easily performed.
　しかも、このシリンジ１１Ｂによれば、図８に示すように、シリンジ１１Ｂの初期状態で、押圧部５０と被押圧部５２とは、軸方向に離間している。このため、押し子１６ａが先端方向に前進する際、押圧部５０は、押し子１６ａが回転し始めた後にガスケット１４Ａの被押圧部５２に当接する。この構成により、ガスケット１４Ａが前進する前にガスケット１４Ａを確実に回転させることができる。従って、シリンジ１１Ｂの使用前に、ガスケット１４Ａの固着解除を確実に遂行することができる。 Moreover, according to this syringe 11B, as shown in FIG. 8, in the initial state of the syringe 11B, the pressing portion 50 and the pressed portion 52 are separated in the axial direction. For this reason, when the pusher 16a advances in the distal direction, the pressing portion 50 comes into contact with the pressed portion 52 of the gasket 14A after the pusher 16a starts to rotate. With this configuration, the gasket 14A can be reliably rotated before the gasket 14A moves forward. Therefore, before the syringe 11B is used, it is possible to reliably release the gasket 14A.
　上述した回転補助部材３６に代えて、図１１に示す回転補助部材３６Ａが用いられてもよい。回転補助部材３６Ａは、バレル１２のフランジ部１２ｄが挿入可能なＵ字状の装着溝５４を有するとともに、バレル１２の側方からフランジ部１２ｄの先端面及び基端面に沿ってスライドさせることによりフランジ部１２ｄに装着可能に構成されている。この構成により、回転補助部材３６Ａをフランジ部１２ｄに簡単に装着することができる。 Instead of the rotation assisting member 36 described above, a rotation assisting member 36A shown in FIG. 11 may be used. The rotation assisting member 36A has a U-shaped mounting groove 54 into which the flange portion 12d of the barrel 12 can be inserted, and is slid along the distal end surface and the proximal end surface of the flange portion 12d from the side of the barrel 12. It is configured to be attachable to the portion 12d. With this configuration, the rotation assisting member 36A can be easily attached to the flange portion 12d.
　図１２に示す本実施形態に係る薬液投与装置５６は、薬液Ｍを生体内に投与するために使用される。薬液投与装置５６は、バレル６６内に充填された薬液Ｍを押し子７０の押圧作用下に比較的長い時間（例えば、数分～数時間程度）をかけて持続的に生体内に投与する。薬液投与装置５６は、薬液Ｍを間欠的に生体内に投与してもよい。薬液Ｍとしては、例えば、タンパク質製剤、麻薬性鎮痛薬、利尿薬等が挙げられる。 12 is used to administer the medicinal solution M into the living body. The medicinal solution administration device 56 continuously administers the medicinal solution M filled in the barrel 66 into the living body under a pressing action of the pusher 70 over a relatively long time (for example, several minutes to several hours). The chemical solution administration device 56 may intermittently administer the chemical solution M into the living body. Examples of the drug solution M include protein preparations, narcotic analgesics, diuretics and the like.
　薬液投与装置５６の使用時において、薬液投与装置５６には投与器具５８として例えばパッチ式の針付きチューブ５９が接続され、バレル６６から吐出された薬液Ｍが針付きチューブ５９を介して患者の体内に注入される。針付きチューブ５９は、バレル６６の筒先部６６ｃに接続可能なコネクタ６０と、一端部がコネクタ６０に接続された可撓性を有する送液チューブ６１と、送液チューブ６１の他端に接続され皮膚Ｓに貼着可能なパッチ部６２と、パッチ部６２から突出した穿刺針６３とを備える。穿刺針６３は皮膚Ｓに対して略垂直に穿刺される。なお、穿刺針６３は皮膚Ｓに対して斜めに穿刺されるものであってもよい。 When the drug solution administration device 56 is used, for example, a patch-type needle-attached tube 59 is connected to the drug solution administration device 56 as the administration device 58, and the drug solution M discharged from the barrel 66 passes through the needle-attached tube 59 to the body of the patient. Injected into. The tube 59 with a needle is connected to a connector 60 that can be connected to the tube tip 66 c of the barrel 66, a flexible liquid feeding tube 61 having one end connected to the connector 60, and the other end of the liquid feeding tube 61. A patch portion 62 that can be attached to the skin S and a puncture needle 63 protruding from the patch portion 62 are provided. The puncture needle 63 is punctured substantially perpendicular to the skin S. The puncture needle 63 may be punctured obliquely with respect to the skin S.
　なお、薬液投与装置５６に接続される投与器具５８は上述したパッチ式の針付きチューブ５９に限らず、例えば、送液チューブ６１の先端に穿刺針（翼状針等）が接続されたものであってもよい。あるいは、投与器具５８は、送液チューブ６１を介さずにバレル６６の筒先部６６ｃに接続可能な屈曲した針であってもよい。この場合、屈曲した針は、例えばバレル６６の筒先部６６ｃから下方に略９０°屈曲しており、薬液投与装置５６の皮膚Ｓへの固定（貼り付け）に伴い皮膚Ｓに対して垂直に穿刺される。また、バレル６６の筒先部６６ｃと投与器具５８及び針の一部はバレル６６の内部にあり、針の先端がバレル６６より突出している形であってもよい。この場合でも、薬液投与装置５６の皮膚Ｓへの固定（貼り付け）に伴い、針が皮膚Ｓに対して垂直に穿刺される。 The administration device 58 connected to the drug solution administration device 56 is not limited to the above-described patch-type tube 59 with a needle, and is, for example, a device in which a puncture needle (such as a winged needle) is connected to the tip of the liquid delivery tube 61. May be. Alternatively, the administration device 58 may be a bent needle that can be connected to the tube tip portion 66 c of the barrel 66 without using the liquid feeding tube 61. In this case, the bent needle is bent, for example, approximately 90 ° downward from the tube tip 66c of the barrel 66, and punctures perpendicularly to the skin S as the drug solution administration device 56 is fixed (attached) to the skin S. Is done. Further, the barrel tip portion 66c of the barrel 66, the administration device 58, and a part of the needle may be inside the barrel 66, and the tip of the needle may protrude from the barrel 66. Even in this case, the needle is punctured perpendicularly to the skin S as the drug solution administration device 56 is fixed (attached) to the skin S.
　図１２及び図１３に示すように、薬液投与装置５６は、薬液Ｍが充填されたバレル６６と、バレル６６内に摺動可能に配置されたガスケット６８と、ガスケット６８に接続されるとともにバレル６６に対して軸方向に移動可能な押し子７０と、押し子７０を先端方向へ前進させる駆動部７２と、バレル６６、ガスケット６８及び押し子７０からなるバレル組立体１０Ｃと駆動部７２とを収容するハウジング７４とを備える。 As shown in FIGS. 12 and 13, the medicinal solution administration device 56 is connected to the barrel 66 filled with the medicinal solution M, the gasket 68 slidably disposed in the barrel 66, and connected to the gasket 68 and the barrel 66. A pusher 70 that is movable in the axial direction with respect to the actuator, a drive unit 72 that advances the pusher 70 in the distal direction, and a barrel assembly 10C that includes the barrel 66, the gasket 68, and the pusher 70, and the drive unit 72 are accommodated. And a housing 74.
　詳細は図示しないが、ハウジング７４内には、薬液投与装置５６の動作に必要な電力を供給する電池、薬液投与装置５６の動作を制御する制御部（マイクロコンピュータ）、スピーカ等が配置されている。ハウジング７４は、上ハウジング７４Ａ及び下ハウジング７４Ｂを有する。ハウジング７４には、各種操作用の複数のボタン７６ａ～７６ｄと、薬液投与装置５６の動作状態等を知らせる複数の発光部７８ａ、７８ｂとが設けられている。 Although details are not shown, a battery for supplying power necessary for the operation of the drug solution administration device 56, a control unit (microcomputer) for controlling the operation of the drug solution administration device 56, a speaker, and the like are arranged in the housing 74. . The housing 74 has an upper housing 74A and a lower housing 74B. The housing 74 is provided with a plurality of buttons 76a to 76d for various operations and a plurality of light emitting portions 78a and 78b for informing the operation state of the drug solution administration device 56 and the like.
　バレル６６は、内部に薬液Ｍの充填空間６７を有する中空円筒状に形成されている。図１３及び図１４に示すように、バレル６６は、その軸方向に内径及び外径が一定であり基端が開口した胴部６６ａと、胴部６６ａの先端から先端方向に向かって内径及び外径がテーパ状に縮径する肩部６６ｂと、肩部６６ｂから先端方向に突出した筒先部６６ｃと、胴部６６ａの基端から径方向外側に突出したフランジ部６６ｄとを有する。 The barrel 66 is formed in a hollow cylindrical shape having a filling space 67 for the chemical solution M therein. As shown in FIGS. 13 and 14, the barrel 66 has an inner diameter and an outer diameter that are constant in the axial direction and a base end that is open at the base end, and an inner diameter and an outer diameter that extend from the distal end of the barrel 66a toward the distal end. It has a shoulder portion 66b whose diameter is reduced in a tapered shape, a tube tip portion 66c protruding from the shoulder portion 66b in the distal direction, and a flange portion 66d protruding outward in the radial direction from the base end of the body portion 66a.
　充填空間６７と連通する薬液吐出口６６ｅが筒先部６６ｃに形成されている。筒先部６６ｃの内腔は、薬液吐出口６６ｅと充填空間６７とを連通する流路を構成している。フランジ部６６ｄは、長軸と短軸とを有する非円形形状に形成されている。 A chemical discharge port 66e communicating with the filling space 67 is formed in the tube tip portion 66c. The lumen of the tube tip portion 66c constitutes a flow path that connects the chemical solution discharge port 66e and the filling space 67. The flange portion 66d is formed in a non-circular shape having a major axis and a minor axis.
　薬液Ｍはバレル６６内に予め充填されている。なお、薬液Ｍは薬液投与装置５６を使用する直前にバレル６６内に充填されてもよい。薬液吐出口６６ｅは、ゴム材やエラストマー材等の弾性樹脂材料からなる封止部材６９によって液密に封止されている。封止部材６９は、図１２に示したコネクタ６０が筒先部６６ｃに接続される際に、コネクタ６０に設けられた針６０ａにより穿刺される。封止部材６９は、先端に開口部を有するキャップ７３によってバレル６６の先端部に固定されている。封止部材６９の先端面は、キャップ７３の開口部から露出している。 The chemical solution M is filled in the barrel 66 in advance. The drug solution M may be filled in the barrel 66 immediately before using the drug solution administration device 56. The chemical solution discharge port 66e is liquid-tightly sealed by a sealing member 69 made of an elastic resin material such as a rubber material or an elastomer material. The sealing member 69 is punctured by a needle 60a provided on the connector 60 when the connector 60 shown in FIG. 12 is connected to the tube tip portion 66c. The sealing member 69 is fixed to the tip of the barrel 66 by a cap 73 having an opening at the tip. The distal end surface of the sealing member 69 is exposed from the opening of the cap 73.
　ガスケット６８は、ゴム材やエラストマー材等の弾性樹脂材料からなり、その外周部がバレル６６（胴部６６ａ）の内周面と液密に密着することにより、充填空間６７の基端側を液密に閉じている。図３等に示したガスケット１４と同様に、ガスケット６８には、内周面に回転防止用溝２０が設けられた第１凹部２２ａと、内周面に第１リブ３０が設けられた第２凹部２２ｂとを有する凹部２２が設けられている。 The gasket 68 is made of an elastic resin material such as a rubber material or an elastomer material, and the outer peripheral portion thereof is in liquid-tight contact with the inner peripheral surface of the barrel 66 (body portion 66a), so that the base end side of the filling space 67 is liquid-filled. Closely closed. Similar to the gasket 14 shown in FIG. 3 and the like, the gasket 68 has a first recess 22a in which the rotation preventing groove 20 is provided on the inner peripheral surface, and a second rib in which the first rib 30 is provided on the inner peripheral surface. A recess 22 having a recess 22b is provided.
　押し子７０は、薬液Ｍを押し出すために軸方向に移動可能な部材である。押し子７０の先端部２６にガスケット６８が接続されている。押し子７０は、押し子７０の主要部（胴体）を構成するロッド部８０と、ロッド部８０の先端から先端方向に突出するとともにガスケット６８に接続された先端部２６とを有する。押し子７０の先端部２６は、ガスケット６８の凹部２２に挿入されている。先端部２６は、図２等に示した押し子１６の先端部２６と同じ構成を有する。 The pusher 70 is a member that can move in the axial direction in order to push out the chemical M. A gasket 68 is connected to the distal end portion 26 of the pusher 70. The pusher 70 includes a rod portion 80 that constitutes a main portion (body) of the pusher 70, and a distal end portion 26 that protrudes from the distal end of the rod portion 80 in the distal direction and is connected to the gasket 68. The distal end portion 26 of the pusher 70 is inserted into the concave portion 22 of the gasket 68. The distal end portion 26 has the same configuration as the distal end portion 26 of the pusher 16 shown in FIG.
　図１５に示すように、ロッド部８０には、押し子７０の軸に沿って延在するとともにロッド部８０の外周面（下面）に開口するスロット８０ａが設けられている。スロット８０ａは、ロッド部８０の基端部にて基端方向にも開口している。 As shown in FIG. 15, the rod portion 80 is provided with a slot 80 a that extends along the axis of the pusher 70 and opens to the outer peripheral surface (lower surface) of the rod portion 80. The slot 80 a is also opened in the proximal direction at the proximal end portion of the rod portion 80.
　図１４に示すように、駆動部７２は、押し子７０を先端方向へ前進させる前進機構８２と、押し子７０を先端方向へ前進させるように前進機構８２を駆動する駆動機構８４とを有する。 As shown in FIG. 14, the drive unit 72 includes an advance mechanism 82 that advances the pusher 70 in the distal direction, and a drive mechanism 84 that drives the advance mechanism 82 to advance the pusher 70 in the distal direction.
　駆動機構８４は、モータ８５（例えば、ギアードモータ）と、モータ８５の出力軸に固定された駆動歯車であるピニオン８６とを有する。前進機構８２は、ピニオン８６によって回転駆動される送りねじ８８と、送りねじ８８と螺合したナット部材９０とを有する。 The drive mechanism 84 includes a motor 85 (for example, a geared motor) and a pinion 86 that is a drive gear fixed to the output shaft of the motor 85. The advance mechanism 82 includes a feed screw 88 that is rotationally driven by a pinion 86 and a nut member 90 that is screwed into the feed screw 88.
　送りねじ８８は、バレル６６の軸に沿って配置されるとともに、押し子７０のスロット８０ａに挿入されている。送りねじ８８は、ピニオン８６と噛み合う従動歯車である大歯車８８ａと、大歯車８８ａよりも先端側の外周面に軸方向の所定範囲に亘って形成された雄ねじ８８ｂとを有する。送りねじ８８の基端部は、シャーシ部材９２に固定された支持部材９３によって回転可能に支持されている。送りねじ８８の先端部２６は、シャーシ部材９２に固定された先端側支持部材９４によって回転可能に支持されている。 The feed screw 88 is disposed along the axis of the barrel 66 and is inserted into the slot 80 a of the pusher 70. The feed screw 88 includes a large gear 88a that is a driven gear that meshes with the pinion 86, and a male screw 88b that is formed on the outer peripheral surface on the tip side of the large gear 88a over a predetermined range in the axial direction. The proximal end portion of the feed screw 88 is rotatably supported by a support member 93 fixed to the chassis member 92. The distal end portion 26 of the feed screw 88 is rotatably supported by a distal end side support member 94 fixed to the chassis member 92.
　ナット部材９０は、例えば硬質樹脂材料により構成されるとともに、送りねじ８８の雄ねじ８８ｂが螺合する雌ねじ９１（ねじ孔）を有する雌ねじ部である。送りねじ８８の回転に伴ってナット部材９０は軸方向に移動する。具体的に、ナット部材９０は、雌ねじ９１が形成されたナット本体９０ａと、ナット本体９０ａの一端部に設けられたスライド部９０ｂとを有する。なお、ナット部材９０を省略して、押し子７０に雌ねじ９１とスライド部９０ｂを設けてもよい。 The nut member 90 is a female screw portion that is made of, for example, a hard resin material and has a female screw 91 (screw hole) into which the male screw 88b of the feed screw 88 is screwed. As the feed screw 88 rotates, the nut member 90 moves in the axial direction. Specifically, the nut member 90 includes a nut main body 90a in which a female screw 91 is formed, and a slide portion 90b provided at one end of the nut main body 90a. The nut member 90 may be omitted and the pusher 70 may be provided with the female screw 91 and the slide portion 90b.
　ナット本体９０ａには軸方向に貫通した一対の孔部９０ｃが形成されており、当該一対の孔部９０ｃに、ロッド部８０の基端に設けられたツメ部８０ｂ（図１５）が係合している。ナット本体９０ａの外面には、例えば金属材料等により構成された補強カバー９０ｄが装着されている。補強カバー９０ｄは、押し子７０の基端に設けられた複数の保持部８０ｃにより保持されている。 A pair of holes 90c penetrating in the axial direction is formed in the nut main body 90a, and a claw 80b (FIG. 15) provided at the base end of the rod 80 is engaged with the pair of holes 90c. ing. A reinforcing cover 90d made of, for example, a metal material is attached to the outer surface of the nut main body 90a. The reinforcing cover 90d is held by a plurality of holding portions 80c provided at the proximal end of the pusher 70.
　図１４に示すように、スライド部９０ｂは、シャーシ部材９２に固定されるとともに送りねじ８８と平行に延在するガイドレール８９によって、軸方向にスライド可能に支持されている。このため、ナット部材９０は、送りねじ８８の回転に伴って押し子７０の軸方向に滑らかに移動可能となっている。具体的に、スライド部９０ｂは、ガイドレール８９に形成されたガイド溝８９ａに挿入されている。ガイド溝８９ａは、押し子７０の軸方向に沿って延在している。 As shown in FIG. 14, the slide portion 90 b is supported by a guide rail 89 that is fixed to the chassis member 92 and extends in parallel with the feed screw 88 so as to be slidable in the axial direction. For this reason, the nut member 90 can move smoothly in the axial direction of the pusher 70 as the feed screw 88 rotates. Specifically, the slide portion 90 b is inserted into a guide groove 89 a formed in the guide rail 89. The guide groove 89 a extends along the axial direction of the pusher 70.
　図１３に示すように、バレル６６及び駆動部７２は、下ハウジング７４Ｂに固定されたシャーシ部材９２を介してハウジング７４に固定されている。シャーシ部材９２は、複数の締結部品９５（図示例では、ねじ）によりハウジング７４に固定されている。 As shown in FIG. 13, the barrel 66 and the drive unit 72 are fixed to the housing 74 via a chassis member 92 fixed to the lower housing 74B. The chassis member 92 is fixed to the housing 74 by a plurality of fastening parts 95 (screws in the illustrated example).
　バレル６６は、フランジ部６６ｄにおいてシャーシ部材９２と係合することで、シャーシ部材９２に固定されている。シャーシ部材９２は、ベースプレート部９８と、ベースプレート部９８の上面からベースプレート部９８の厚さ方向（上方）に突出するとともにフランジ部６６ｄが装着されたフランジ装着部１００とを有する。シャーシ部材９２に代えて、バレル６６及び駆動部７２を支持する支持部が、ハウジング７４に一体的に設けられていてもよい。 The barrel 66 is fixed to the chassis member 92 by engaging with the chassis member 92 at the flange portion 66d. The chassis member 92 includes a base plate portion 98 and a flange mounting portion 100 that protrudes from the upper surface of the base plate portion 98 in the thickness direction (upward) of the base plate portion 98 and has a flange portion 66d mounted thereon. Instead of the chassis member 92, a support portion that supports the barrel 66 and the drive portion 72 may be provided integrally with the housing 74.
　次に、上記のように構成された薬液投与装置５６の作用を説明する。 Next, the operation of the drug solution administration device 56 configured as described above will be described.
　薬液投与装置５６の使用に際し、薬液投与装置５６は保冷庫から取り出され、常温放置されて室温に戻される。次に、コネクタ６０との接続部である封止部材６９の表面（先端面）が例えばアルコール綿等で拭き取られることにより、接続部の消毒がなされる。次に、薬液投与装置５６には投与器具５８が接続される。 When using the chemical solution administration device 56, the chemical solution administration device 56 is taken out of the cold storage, left at room temperature, and returned to room temperature. Next, the surface (tip surface) of the sealing member 69 that is a connection portion with the connector 60 is wiped off with, for example, alcohol cotton, so that the connection portion is sterilized. Next, an administration device 58 is connected to the drug solution administration device 56.
　次に、電源ボタン７６ａが所定時間以上押される（長押しされる）と、第１発光部７８ａが第１の色で点灯し、スピーカから開始音が報知されるとともに電源が入る。次に、プライミングボタン７６ｂが押され続けると、第１発光部７８ａが第１の色で点滅し、プライミング（投与器具５８内の流路を薬液Ｍで満たすこと）が行われる。この場合、針先６３ａから薬液Ｍが垂れたことを目視確認することで、プライミングの完了を把握することができる。 Next, when the power button 76a is pressed for a predetermined time or longer (long press), the first light emitting unit 78a is lit in the first color, the start sound is notified from the speaker, and the power is turned on. Next, when the priming button 76b is continuously pressed, the first light emitting portion 78a blinks in the first color, and priming (filling the flow path in the administration device 58 with the drug solution M) is performed. In this case, the completion of the priming can be grasped by visually confirming that the chemical M has dripped from the needle tip 63a.
　そして、薬液投与装置５６は、皮膚Ｓに貼り付ける、あるいは衣服に装着する等して、患者に取り付けられる。次に、穿刺針６３が皮膚Ｓに穿刺される。なお、皮膚Ｓへの穿刺針６３の穿刺前に薬液投与装置５６が患者に取り付けられてもよい。 Then, the drug solution administration device 56 is attached to the patient by being attached to the skin S or attached to clothes. Next, the puncture needle 63 is punctured into the skin S. In addition, before the puncture needle 63 punctures the skin S, the chemical solution administration device 56 may be attached to the patient.
　そして、送液ボタン７６ｃが所定時間以上押されると、第１発光部５４ａが第２の色（第１の色とは異なる色）で点滅し、送液（薬液Ｍの投与）が開始される。 When the liquid feeding button 76c is pressed for a predetermined time or longer, the first light emitting unit 54a blinks in the second color (color different from the first color), and liquid feeding (administration of the drug solution M) is started. .
　具体的には、送液ボタン７６ｃが操作されることで薬液投与装置５６の制御部が送液開始を判断すると、モータ８５が駆動してピニオン８６から大歯車８８ａを有する送りねじ８８へと回転力が伝達される。送りねじ８８の回転に伴い、送りねじ８８と螺合しているナット部材９０が前進し、ナット部材９０により押し子７０が押されて前進する。これにより、バレル６６内の薬液Ｍが押し出される。バレル６６内から押し出された薬液Ｍは、患者に穿刺された投与器具５８を介して患者の体内に投与（注入）される。 Specifically, when the liquid feeding button 76c is operated and the control unit of the liquid medicine administration device 56 determines that liquid feeding is started, the motor 85 is driven to rotate from the pinion 86 to the feeding screw 88 having the large gear 88a. Power is transmitted. As the feed screw 88 rotates, the nut member 90 screwed with the feed screw 88 moves forward, and the pusher 70 is pushed forward by the nut member 90 and moves forward. Thereby, the chemical | medical solution M in the barrel 66 is extruded. The medicinal solution M pushed out from the barrel 66 is administered (injected) into the patient's body through the administration device 58 punctured by the patient.
　押し子７０が所定位置まで前進することで送液が完了すると、薬液投与装置５６に内蔵されたスピーカから送液完了を知らせる音が出力されるとともに、第１発光部７８ａが第１の色で点灯する。送液が完了したら、穿刺針６３が皮膚Ｓ（皮下）から抜き取られる。その後、薬液投与装置５６は廃棄される。 When liquid feeding is completed by the pusher 70 moving forward to a predetermined position, a sound notifying completion of liquid feeding is output from a speaker built in the drug solution administration device 56, and the first light emitting unit 78a is in the first color. Light. When the liquid feeding is completed, the puncture needle 63 is extracted from the skin S (subcutaneous). Thereafter, the chemical solution administration device 56 is discarded.
　次に、薬液投与装置５６の組立方法を説明する。 Next, a method for assembling the chemical solution administration device 56 will be described.
　図１６に示すように、バレル６６の筒先部６６ｃの先端面とキャップ７３との間に封止部材６９が挟持されるようにキャップ７３及び封止部材６９を筒先部６６ｃに取り付ける。筒先部６６ｃへのキャップ７３の取付けに伴い、キャップ７３が筒先部６６ｃの外周部に係合するとともに、先端開口部が封止部材６９によって液密に封止される。次に、バレル６６内に薬液Ｍを注入した後、ガスケット６８を例えば真空打栓法等によりバレル６６内に挿入する（ガスケット挿入ステップ）。 As shown in FIG. 16, the cap 73 and the sealing member 69 are attached to the tube tip portion 66 c so that the sealing member 69 is sandwiched between the tip end surface of the tube tip portion 66 c of the barrel 66 and the cap 73. With the attachment of the cap 73 to the tube tip portion 66c, the cap 73 engages with the outer peripheral portion of the tube tip portion 66c, and the tip opening is sealed in a liquid-tight manner by the sealing member 69. Next, after the chemical solution M is injected into the barrel 66, the gasket 68 is inserted into the barrel 66 by, for example, a vacuum stopper method (gasket insertion step).
　次に、図１７Ａ及び図１７Ｂに示すように、バレル６６のフランジ部６６ｄの短軸とロッド部８０のスロット８０ａの開口方向とを略一致させた状態で、第１リブ３０と第２リブ３１とを係合させるとともに、回転防止用溝２０に回転防止用突起２１を挿入することにより、ガスケット６８と押し子７０とを接続する（接続ステップ）。これにより、所定状態に組み立てられたバレル組立体１０Ｃが得られる。 Next, as shown in FIGS. 17A and 17B, the first rib 30 and the second rib 31 are made with the short axis of the flange portion 66 d of the barrel 66 and the opening direction of the slot 80 a of the rod portion 80 being substantially coincident with each other. And the gasket 68 and the pusher 70 are connected by inserting the anti-rotation protrusion 21 into the anti-rotation groove 20 (connection step). Thereby, the barrel assembly 10C assembled in a predetermined state is obtained.
　次に、図１８に示すように、ロッド部８０のスロット８０ａに送りねじ８８が挿入されるようにバレル組立体１０Ｃをハウジング７４内に配置する（配置ステップ）。具体的に、配置ステップに先行して、シャーシ部材９２に駆動部７２が取り付けられ且つ下ハウジング７４Ｂにシャーシ部材９２が固定された組立体が用意される。従って、配置ステップでは、下ハウジング７４Ｂに対して、バレル組立体１０Ｃが組み付けられる。その際、バレル６６のフランジ部６６ｄが、シャーシ部材９２のフランジ装着部１００に挿入され保持される。 Next, as shown in FIG. 18, the barrel assembly 10C is disposed in the housing 74 so that the feed screw 88 is inserted into the slot 80a of the rod portion 80 (arrangement step). Specifically, prior to the arranging step, an assembly is prepared in which the drive unit 72 is attached to the chassis member 92 and the chassis member 92 is fixed to the lower housing 74B. Accordingly, in the arranging step, the barrel assembly 10C is assembled to the lower housing 74B. At that time, the flange portion 66 d of the barrel 66 is inserted and held in the flange mounting portion 100 of the chassis member 92.
　次に、送りねじ８８を回転させることによりナット部材９０を押し子７０に向かって前進させ、押し子７０の基端部とナット部材９０とを連結する。この際、押し子７０のツメ部８０ｂが内側に弾性変形しながらナット部材９０の孔部９０ｃに挿入され、ツメ部８０ｂが孔部９０ｃを乗り越えることに伴ってツメ部８０ｂがナット部材９０の基端面に係合する。 Next, the nut member 90 is advanced toward the pusher 70 by rotating the feed screw 88, and the base end portion of the pusher 70 and the nut member 90 are connected. At this time, the claw portion 80b of the pusher 70 is inserted into the hole portion 90c of the nut member 90 while elastically deforming inward, and the claw portion 80b moves over the hole portion 90c so that the claw portion 80b becomes the base of the nut member 90. Engage with the end face.
　次に、電池等が取り付けられた図示しない基板が下ハウジング７４Ｂに取り付けられる。そして、下ハウジング７４Ｂに上ハウジング７４Ａが取り付けられる。これにより、図１２に示した薬液投与装置５６が得られる。 Next, a substrate (not shown) to which a battery or the like is attached is attached to the lower housing 74B. Then, the upper housing 74A is attached to the lower housing 74B. Thereby, the chemical | medical solution administration apparatus 56 shown in FIG. 12 is obtained.
　この場合、本実施形態に係る薬液投与装置５６は、以下の効果を奏する。 In this case, the drug solution administration device 56 according to the present embodiment has the following effects.
　薬液投与装置５６では、回転防止用溝２０と回転防止用突起２１との係合により、バレル６６と押し子７０との相対回転が防止され、且つ第１リブ３０と第２リブ３１との係合により、バレル６６からの押し子７０の離脱が防止される。このため、薬液投与装置５６の組立工程において、バレル６６と押し子７０の軸回りの位相を適切な位置に合わせ且つその位置を保持した状態で、バレル組立体１０Ｃをハウジング７４内の所定位置に容易に配置することが可能となる。このため、バレル組立体１０Ｃをハウジング７４内に配置する際に、ガスケット６８と押し子７０との距離が変わったり、ガスケット６８を移動させてしまったりすることがなく、液漏れやそれに伴う汚染を防止することができる。 In the chemical solution administration device 56, the engagement between the rotation prevention groove 20 and the rotation prevention protrusion 21 prevents relative rotation between the barrel 66 and the pusher 70, and the relationship between the first rib 30 and the second rib 31. Accordingly, the pusher 70 is prevented from being detached from the barrel 66. For this reason, in the assembly process of the drug solution administration device 56, the barrel assembly 10C is brought into a predetermined position in the housing 74 in a state where the phase around the axis of the barrel 66 and the pusher 70 is adjusted to an appropriate position and the position is maintained. It can be easily arranged. For this reason, when the barrel assembly 10C is disposed in the housing 74, the distance between the gasket 68 and the pusher 70 is not changed, and the gasket 68 is not moved. Can be prevented.
　本発明は上述した実施形態に限定されるものではなく、本発明の要旨を逸脱しない範囲において、種々の改変が可能である。 The present invention is not limited to the above-described embodiment, and various modifications can be made without departing from the gist of the present invention.

Claims (15)

  1. 　薬液（Ｍ）が充填可能なバレル（１２、６６）と、
    　前記バレル（１２、６６）内に摺動可能に配置されたガスケット（１４、１４Ａ、６８）と、
    　前記ガスケット（１４、１４Ａ、６８）に接続されるように構成され、前記ガスケット（１４、１４Ａ、６８）を先端方向に押圧可能な押し子（１６、１６ａ、７０）と、を備え、
    　前記ガスケット（１４、１４Ａ、６８）及び前記押し子（１６、１６ａ、７０）の一方には、回転防止用溝（２０、２０ａ）が設けられ、
    　前記ガスケット（１４、１４Ａ、６８）及び前記押し子（１６、１６ａ、７０）の他方には、前記回転防止用溝（２０、２０ａ）に挿入されるように構成された回転防止用突起（２１）が設けられ、
    　前記回転防止用溝（２０、２０ａ）と前記回転防止用突起（２１）との係合により、前記ガスケット（１４、１４Ａ、６８）と前記押し子（１６、１６ａ、７０）との相対回転が防止され、
    　前記ガスケット（１４、１４Ａ、６８）には、径方向に突出した第１リブ（３０）が設けられ、
    　前記押し子（１６、１６ａ、７０）には、径方向に突出するとともに、前記第１リブ（３０）の先端面に係合し又は前記先端面に対向するように構成された第２リブ（３１）が設けられ、
    　前記第１リブ（３０）と前記第２リブ（３１）との係合により、前記ガスケット（１４、１４Ａ、６８）からの前記押し子（１６、１６ａ、７０）の離脱が防止される、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     Barrels (12, 66) that can be filled with a medicinal solution (M);
    A gasket (14, 14A, 68) slidably disposed within the barrel (12, 66);
    A pusher (16, 16a, 70) configured to be connected to the gasket (14, 14A, 68) and capable of pressing the gasket (14, 14A, 68) in a distal direction;
    One of the gasket (14, 14A, 68) and the pusher (16, 16a, 70) is provided with a rotation prevention groove (20, 20a),
    The other of the gasket (14, 14A, 68) and the pusher (16, 16a, 70) is provided with an anti-rotation protrusion (21) configured to be inserted into the anti-rotation groove (20, 20a). )
    Relative rotation between the gasket (14, 14A, 68) and the pusher (16, 16a, 70) is caused by the engagement between the rotation prevention groove (20, 20a) and the rotation prevention protrusion (21). Prevented,
    The gasket (14, 14A, 68) is provided with a first rib (30) protruding in the radial direction,
    The pusher (16, 16a, 70) protrudes in the radial direction and engages with the front end surface of the first rib (30) or is opposed to the front end surface (second rib). 31) is provided,
    The engagement between the first rib (30) and the second rib (31) prevents the pusher (16, 16a, 70) from being detached from the gasket (14, 14A, 68).
    A barrel assembly (10A to 10C) characterized by the above.
  2. 　請求項１記載のバレル組立体（１０Ａ～１０Ｃ）において、
    　前記回転防止用溝（２０、２０ａ）は、前記ガスケット（１４、１４Ａ、６８）に設けられ、
    　前記回転防止用突起（２１）は、前記押し子（１６、１６ａ、７０）に設けられている、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     The barrel assembly (10A-10C) according to claim 1,
    The anti-rotation groove (20, 20a) is provided in the gasket (14, 14A, 68),
    The rotation preventing projection (21) is provided on the pusher (16, 16a, 70).
    A barrel assembly (10A to 10C) characterized by the above.
  3. 　請求項１記載のバレル組立体（１０Ａ～１０Ｃ）において、
    　前記ガスケット（１４、１４Ａ、６８）は、前記ガスケット（１４、１４Ａ、６８）の基端面に開口する凹部（２２）を有し、
    　前記押し子（１６、１６ａ、７０）は、前記凹部（２２）に挿入される先端部（２６）を有し、
    　前記回転防止用溝（２０、２０ａ）は、前記凹部（２２）の内周面に設けられるとともに前記ガスケット（１４、１４Ａ、６８）の軸に沿って延在し、
    　前記回転防止用突起（２１）は、前記押し子（１６、１６ａ、７０）の前記先端部（２６）の外周面に設けられるとともに前記押し子（１６、１６ａ、７０）の軸に沿って延在している、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     The barrel assembly (10A-10C) according to claim 1,
    The gasket (14, 14A, 68) has a recess (22) that opens to the base end face of the gasket (14, 14A, 68),
    The pusher (16, 16a, 70) has a tip (26) inserted into the recess (22),
    The anti-rotation groove (20, 20a) is provided on the inner peripheral surface of the recess (22) and extends along the axis of the gasket (14, 14A, 68),
    The rotation preventing protrusion (21) is provided on the outer peripheral surface of the tip (26) of the pusher (16, 16a, 70) and extends along the axis of the pusher (16, 16a, 70). Exist,
    A barrel assembly (10A to 10C) characterized by the above.
  4. 　請求項１記載のバレル組立体（１０Ａ～１０Ｃ）において、
    　前記ガスケット（１４、１４Ａ、６８）は、前記ガスケット（１４、１４Ａ、６８）の基端面に開口する凹部（２２）を有し、
    　前記押し子（１６、１６ａ、７０）は、前記凹部（２２）に挿入された先端部（２６）を有し、
    　前記第１リブ（３０）は、前記凹部（２２）の内周面に設けられるとともに周方向に延在し、
    　前記第２リブ（３１）は、前記押し子（１６、１６ａ、７０）の前記先端部（２６）の外周面に設けられるとともに周方向に延在している、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     The barrel assembly (10A-10C) according to claim 1,
    The gasket (14, 14A, 68) has a recess (22) that opens to the base end face of the gasket (14, 14A, 68),
    The pusher (16, 16a, 70) has a tip (26) inserted into the recess (22),
    The first rib (30) is provided on the inner peripheral surface of the recess (22) and extends in the circumferential direction,
    The second rib (31) is provided on the outer peripheral surface of the tip (26) of the pusher (16, 16a, 70) and extends in the circumferential direction.
    A barrel assembly (10A to 10C) characterized by the above.
  5. 　請求項１記載のバレル組立体（１０Ａ～１０Ｃ）において、
    　前記ガスケット（１４、１４Ａ、６８）は、前記ガスケット（１４、１４Ａ、６８）の基端面に開口する凹部（２２）を有し、
    　前記押し子（１６、１６ａ、７０）は、前記凹部（２２）に挿入された先端部（２６）を有し、
    　前記凹部（２２）は、前記ガスケット（１４、１４Ａ、６８）の基端面に開口した第１凹部（２２ａ）と、前記第１凹部（２２ａ）と同心状に前記第１凹部（２２ａ）の先端側に隣接するとともに前記第１凹部（２２ａ）よりも小径に形成された第２凹部（２２ｂ）とを有し、
    　前記回転防止用溝（２０、２０ａ）は、前記第２凹部（２２ｂ）の内周面に設けられるとともに前記ガスケット（１４、１４Ａ、６８）の軸に沿って延在し、
    　前記回転防止用突起（２１）は、前記先端部（２６）の外周面に前記第２リブ（３１）よりも先端側に設けられるとともに前記押し子（１６、１６ａ、７０）の軸に沿って延在し、
    　前記第１リブ（３０）は、前記第１凹部（２２ａ）の内周面に設けられるとともに周方向に延在し、
    　前記第２リブ（３１）は、前記押し子（１６、１６ａ、７０）の前記先端部（２６）の外周面に設けられるとともに周方向に延在し、
    　前記回転防止用突起（２１）の突出端面は、前記第２リブ（３１）の突出端面よりも径方向内側に位置している、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     The barrel assembly (10A-10C) according to claim 1,
    The gasket (14, 14A, 68) has a recess (22) that opens to the base end face of the gasket (14, 14A, 68),
    The pusher (16, 16a, 70) has a tip (26) inserted into the recess (22),
    The concave portion (22) includes a first concave portion (22a) opened at a base end surface of the gasket (14, 14A, 68), and a tip of the first concave portion (22a) concentrically with the first concave portion (22a). A second recess (22b) that is adjacent to the side and is smaller in diameter than the first recess (22a),
    The anti-rotation groove (20, 20a) is provided on the inner peripheral surface of the second recess (22b) and extends along the axis of the gasket (14, 14A, 68),
    The rotation preventing protrusion (21) is provided on the outer peripheral surface of the tip end portion (26) on the tip end side of the second rib (31) and along the axis of the pusher (16, 16a, 70). Extended,
    The first rib (30) is provided on the inner peripheral surface of the first recess (22a) and extends in the circumferential direction,
    The second rib (31) is provided on the outer peripheral surface of the tip (26) of the pusher (16, 16a, 70) and extends in the circumferential direction,
    The protruding end surface of the rotation preventing projection (21) is located radially inward from the protruding end surface of the second rib (31).
    A barrel assembly (10A to 10C) characterized by the above.
  6. 　請求項１～５のいずれか１項に記載のバレル組立体（１０Ａ～１０Ｃ）において、
    　前記回転防止用溝（２０、２０ａ）は、前記ガスケット（１４、１４Ａ、６８）の軸回りに、５～２０°の間隔で複数設けられている、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     The barrel assembly (10A-10C) according to any one of claims 1 to 5,
    A plurality of the anti-rotation grooves (20, 20a) are provided at intervals of 5 to 20 ° around the axis of the gasket (14, 14A, 68).
    A barrel assembly (10A to 10C) characterized by the above.
  7. 　請求項６に記載のバレル組立体（１０Ａ～１０Ｃ）において、
    　前記回転防止用突起（２１）は、前記押し子（１６、１６ａ、７０）の軸回りに複数設けられており、
    　前記回転防止用突起（２１）の数は、前記回転防止用溝（２０、２０ａ）よりも少ない、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     The barrel assembly (10A-10C) according to claim 6,
    A plurality of the rotation preventing projections (21) are provided around the axis of the pusher (16, 16a, 70),
    The number of the rotation prevention protrusions (21) is less than the rotation prevention grooves (20, 20a).
    A barrel assembly (10A to 10C) characterized by the above.
  8. 　請求項１～７のいずれか１項に記載のバレル組立体（１０Ａ～１０Ｃ）において、
    　前記第１リブ（３０）は、周方向に間隔を置いて複数設けられており、
    　前記第２リブ（３１）は、周方向に一周延在する環状に形成されている、
    　ことを特徴とするバレル組立体（１０Ａ～１０Ｃ）。     The barrel assembly (10A-10C) according to any one of claims 1 to 7,
    A plurality of the first ribs (30) are provided at intervals in the circumferential direction,
    The second rib (31) is formed in an annular shape extending in the circumferential direction.
    A barrel assembly (10A to 10C) characterized by the above.
  9. 　請求項１～８のいずれか１項に記載のバレル組立体（１０Ａ、１０Ｂ）において、
    　前記バレル組立体（１０Ａ、１０Ｂ）は、前記押し子（１６、１６ａ）がユーザによって押されるシリンジであり、
    　前記バレル（１２）と前記ガスケット（１４、１４Ａ）とにより形成される充填空間（１３）には、薬液（Ｍ）が充填されている、
    　ことを特徴とするバレル組立体（１０Ａ、１０Ｂ）。     The barrel assembly (10A, 10B) according to any one of claims 1 to 8,
    The barrel assembly (10A, 10B) is a syringe in which the pusher (16, 16a) is pushed by a user,
    The filling space (13) formed by the barrel (12) and the gasket (14, 14A) is filled with a chemical (M).
    A barrel assembly (10A, 10B).
  10. 　請求項９記載のバレル組立体（１０Ａ）において、
    　前記押し子（１６）の基端部には、外方に突出する押し子フランジ（２８）が設けられ、
    　前記押し子フランジ（２８）の外周部には、指を掛けるための溝部（２８ａ）又は突起が設けられている、
    　ことを特徴とするバレル組立体（１０Ａ）。     The barrel assembly (10A) of claim 9,
    A pusher flange (28) protruding outward is provided at the base end of the pusher (16),
    On the outer periphery of the pusher flange (28), a groove (28a) or a protrusion for hooking a finger is provided.
    A barrel assembly (10A).
  11. 　請求項９記載のバレル組立体（１０Ｂ）において、
    　前記押し子（１６ａ）は、前記バレル（１２）の基端開口を介して前記バレル（１２）に挿入されており、
    　前記バレル（１２）の基端部には、外方に突出したフランジ部（１２ｄ）が設けられ、
    　前記バレル組立体（１０Ｂ）は、前記フランジ部（１２ｄ）に装着されるように構成された回転補助部材（３６）を備え、
    　前記回転補助部材（３６）は、内方に突出するとともに前記バレル（１２）の前記基端開口に対向する押し子回転用突起（３８）を有し、
    　前記押し子（１６ａ）には、前記押し子（１６ａ）が初期位置にあるときに前記押し子回転用突起（３８）よりも基端側で前記押し子回転用突起（３８）に対向するとともに、前記押し子（１６ａ）の軸に対して傾斜した傾斜部（４８）が設けられ、
    　前記押し子（１６ａ）が先端方向に前進する際に、前記傾斜部（４８）が前記押し子回転用突起（３８）に押されることで、前記押し子（１６ａ）が回転する、
    　ことを特徴とするバレル組立体（１０Ｂ）。     The barrel assembly (10B) of claim 9,
    The pusher (16a) is inserted into the barrel (12) through a proximal end opening of the barrel (12),
    The base end of the barrel (12) is provided with a flange portion (12d) protruding outward,
    The barrel assembly (10B) includes a rotation auxiliary member (36) configured to be attached to the flange portion (12d),
    The rotation assisting member (36) has a pusher rotation protrusion (38) that protrudes inward and faces the proximal end opening of the barrel (12).
    The pusher (16a) is opposed to the pusher rotation protrusion (38) on the base end side with respect to the pusher rotation protrusion (38) when the pusher (16a) is in the initial position. An inclined portion (48) inclined with respect to the axis of the pusher (16a) is provided,
    When the pusher (16a) advances in the distal direction, the inclined portion (48) is pushed by the pusher rotation protrusion (38), whereby the pusher (16a) rotates.
    A barrel assembly (10B).
  12. 　請求項９記載のバレル組立体（１０Ｂ）において、
    　前記押し子（１６ａ）は、前記ガスケット（１４Ａ）を先端方向に押圧可能な押圧部（５０）を有し、
    　前記ガスケット（１４Ａ）は、前記押圧部（５０）と対向する位置に設けられた被押圧部（５２）を有し、
    　前記シリンジの初期状態で、前記押圧部（５０）と前記被押圧部（５２）とは、軸方向に離間しており、
    　前記押し子（１６ａ）が先端方向に前進する際、前記押圧部（５０）は、前記押し子（１６ａ）が回転し始めた後に前記ガスケット（１４Ａ）の前記被押圧部（５２）に当接する、
    　ことを特徴とするバレル組立体（１０Ｂ）。     The barrel assembly (10B) of claim 9,
    The pusher (16a) has a pressing part (50) capable of pressing the gasket (14A) in the distal direction,
    The gasket (14A) has a pressed part (52) provided at a position facing the pressing part (50),
    In the initial state of the syringe, the pressing portion (50) and the pressed portion (52) are separated in the axial direction,
    When the pusher (16a) advances in the distal direction, the pressing portion (50) contacts the pressed portion (52) of the gasket (14A) after the pusher (16a) starts to rotate. ,
    A barrel assembly (10B).
  13. 　薬液（Ｍ）が充填されたバレル（１２、６６）と、前記バレル（１２、６６）内に摺動可能に配置されたガスケット（１４、１４Ａ、６８）と、前記ガスケット（１４、１４Ａ、６８）に接続され、前記ガスケット（１４、１４Ａ、６８）を先端方向に押圧可能な押し子（１６、１６ａ、７０）とを備えたシリンジの使用方法であって、
    　前記ガスケット（１４、１４Ａ、６８）及び前記押し子（１６、１６ａ、７０）の一方には、回転防止用溝（２０、２０ａ）が設けられ、
    　前記ガスケット（１４、１４Ａ、６８）及び前記押し子（１６、１６ａ、７０）の他方には、前記回転防止用溝（２０、２０ａ）に挿入された回転防止用突起（２１）が設けられ、
    　前記回転防止用溝（２０、２０ａ）に前記回転防止用突起（２１）との係合により、前記ガスケット（１４、１４Ａ、６８）と前記押し子（１６、１６ａ、７０）との相対回転が防止され、
    　前記ガスケット（１４、１４Ａ、６８）には、径方向に突出した第１リブ（３０）が設けられ、
    　前記押し子（１６、１６ａ、７０）には、径方向に突出するとともに、前記第１リブ（３０）の先端面に係合し又は前記先端面に対向する第２リブ（３１）が設けられ、
    　前記第１リブ（３０）と前記第２リブ（３１）との係合により、前記ガスケット（１４、１４Ａ、６８）からの前記押し子（１６、１６ａ、７０）の離脱が防止され、
    　前記使用方法は、
    　前記ガスケット（１４、１４Ａ、６８）を前進させる前に、前記押し子（１６、１６ａ、７０）を回転させることで、前記回転防止用溝（２０、２０ａ）と前記回転防止用突起（２１）との係合を介して前記バレル（１２、６６）内で前記ガスケット（１４、１４Ａ、６８）を回転させる回転ステップと、
    　前記ガスケット（１４、１４Ａ、６８）が少なくとも回転し始めた後に前記押し子（１６、１６ａ、７０）を前進させることで、前記ガスケット（１４、１４Ａ、６８）を前記バレル（１２、６６）内で前進させる前進ステップと、を含む、
    　ことを特徴とするシリンジの使用方法。     A barrel (12, 66) filled with a chemical (M), a gasket (14, 14A, 68) slidably disposed in the barrel (12, 66), and the gasket (14, 14A, 68) ), And a pusher (16, 16a, 70) that can press the gasket (14, 14A, 68) in the distal direction,
    One of the gasket (14, 14A, 68) and the pusher (16, 16a, 70) is provided with a rotation prevention groove (20, 20a),
    The other of the gasket (14, 14A, 68) and the pusher (16, 16a, 70) is provided with an anti-rotation protrusion (21) inserted into the anti-rotation groove (20, 20a),
    The relative rotation between the gasket (14, 14A, 68) and the pusher (16, 16a, 70) is caused by the engagement of the rotation prevention protrusion (21) with the rotation prevention groove (20, 20a). Prevented,
    The gasket (14, 14A, 68) is provided with a first rib (30) protruding in the radial direction,
    The pusher (16, 16a, 70) is provided with a second rib (31) that protrudes in the radial direction and engages with the front end surface of the first rib (30) or faces the front end surface. ,
    The engagement between the first rib (30) and the second rib (31) prevents the pusher (16, 16a, 70) from being detached from the gasket (14, 14A, 68),
    The usage is as follows:
    By rotating the pusher (16, 16a, 70) before the gasket (14, 14A, 68) is advanced, the anti-rotation groove (20, 20a) and the anti-rotation protrusion (21) are rotated. Rotating the gasket (14, 14A, 68) within the barrel (12, 66) via engagement with
    The gasket (14, 14A, 68) is moved into the barrel (12, 66) by advancing the pusher (16, 16a, 70) after the gasket (14, 14A, 68) starts to rotate at least. An advancing step for advancing at
    The use method of the syringe characterized by the above-mentioned.
  14. 　薬液（Ｍ）を生体内に投与するための薬液投与装置（５６）であって、
    　請求項１～８のいずれか１項に記載のバレル組立体（１０Ｃ）と、
    　前記バレル組立体（１０Ｃ）の前記押し子（７０）を先端方向へ前進させる駆動部（７２）と、
    　前記バレル組立体（１０Ｃ）及び前記駆動部（７２）を収容するハウジング（７４）と、を備え、
    　前記バレル（６６）は、長軸と短軸とを有するフランジ部（１２ｄ）が基端部に設けられ、
    　前記押し子（７０）は、前記ガスケット（６８）に接続された先端部（２６）と、前記押し子（７０）の外周面に開口するスロット（８０ａ）が設けられたロッド部（８０）とを有し、
    　前記駆動部（７２）は、前記スロット（８０ａ）に挿入された送りねじ（８８）を有し、
    　前記フランジ部（１２ｄ）の前記短軸と前記ロッド部（８０）の前記スロット（８０ａ）の開口方向とが略一致している、
    　ことを特徴とする薬液投与装置（５６）。     A drug solution administration device (56) for administering a drug solution (M) into a living body,
    A barrel assembly (10C) according to any one of the preceding claims,
    A drive unit (72) for advancing the pusher (70) of the barrel assembly (10C) in the distal direction;
    A housing (74) for accommodating the barrel assembly (10C) and the drive unit (72),
    The barrel (66) is provided with a flange portion (12d) having a major axis and a minor axis at a proximal end portion,
    The pusher (70) includes a tip part (26) connected to the gasket (68), and a rod part (80) provided with a slot (80a) opened on an outer peripheral surface of the pusher (70). Have
    The drive part (72) has a lead screw (88) inserted into the slot (80a),
    The short axis of the flange portion (12d) and the opening direction of the slot (80a) of the rod portion (80) are substantially coincided with each other.
    A medicinal-solution administration device (56).
  15. 　薬液（Ｍ）を生体内に投与するための薬液投与装置（５６）の組立方法であって、
    　前記薬液投与装置（５６）は、
    　長軸と短軸とを有するフランジ部（１２ｄ）が基端部に設けられ、薬液（Ｍ）が充填可能なバレル（６６）と、
    　前記バレル（６６）内に摺動可能に配置されたガスケット（６８）と、
    　前記ガスケット（６８）に接続された先端部（２６）と、外周面に開口するスロット（８０ａ）が設けられたロッド部（８０）とを有し、前記ガスケット（６８）を先端方向に押圧可能な押し子（７０）と、
    　前記スロット（８０ａ）に挿入された送りねじ（８８）を有し、前記押し子（７０）を先端方向へ前進させる駆動部（７２）と、
    　前記バレル（６６）、前記ガスケット（６８）及び前記押し子（７０）を有するバレル組立体（１０Ｃ）と、前記駆動部（７２）とを収容するハウジング（７４）と、を備え、
    　前記ガスケット（６８）及び前記押し子（７０）の一方には、回転防止用溝（２０）が設けられ、
    　前記ガスケット（６８）及び前記押し子（７０）の他方には、前記回転防止用溝（２０）に挿入された回転防止用突起（２１）が設けられ、
    　前記ガスケット（６８）には、前記押し子（７０）に向かって径方向に突出した第１リブ（３０）が設けられ、
    　前記押し子（７０）には、前記ガスケット（６８）に向かって径方向に突出するとともに、前記第１リブ（３０）の先端面に係合し又は前記先端面に対向する第２リブ（３１）が設けられ、
    　前記組立方法は、
    　前記バレル（６６）内の所定位置に前記ガスケット（６８）を挿入するガスケット挿入ステップと、
    　前記フランジ部（１２ｄ）の前記短軸と前記ロッド部（８０）の前記スロット（８０ａ）の開口方向とを略一致させた状態で、前記第１リブ（３０）と前記第２リブ（３１）とを係合させるとともに、前記回転防止用溝（２０）に前記回転防止用突起（２１）を挿入することにより、前記ガスケット（６８）と前記押し子（７０）とを接続し、前記バレル組立体（１０Ｃ）を得る接続ステップと、
    　前記ロッド部（８０）の前記スロット（８０ａ）に前記送りねじ（８８）が挿入されるように前記バレル組立体（１０Ｂ、１０Ｃ）を前記ハウジング（７４）内に配置する配置ステップと、を含む、
    　ことを特徴とする薬液投与装置（５６）の組立方法。     A method of assembling a drug solution administration device (56) for administering a drug solution (M) into a living body,
    The drug solution administration device (56)
    A barrel (66) provided with a flange portion (12d) having a major axis and a minor axis at a base end portion and capable of being filled with a chemical (M);
    A gasket (68) slidably disposed within the barrel (66);
    It has a front end portion (26) connected to the gasket (68) and a rod portion (80) provided with a slot (80a) opened on the outer peripheral surface, and can press the gasket (68) in the front end direction. Nashi pusher (70),
    A drive unit (72) having a feed screw (88) inserted into the slot (80a) and advancing the pusher (70) in the distal direction;
    A barrel assembly (10C) having the barrel (66), the gasket (68), and the pusher (70), and a housing (74) that houses the drive unit (72);
    One of the gasket (68) and the pusher (70) is provided with a rotation prevention groove (20),
    The other of the gasket (68) and the pusher (70) is provided with an anti-rotation protrusion (21) inserted into the anti-rotation groove (20),
    The gasket (68) is provided with a first rib (30) protruding radially toward the pusher (70),
    The pusher (70) protrudes in the radial direction toward the gasket (68), and engages with the front end surface of the first rib (30) or opposes the front end surface. )
    The assembly method is as follows:
    A gasket insertion step of inserting the gasket (68) into place in the barrel (66);
    The first rib (30) and the second rib (31) in a state where the short axis of the flange portion (12d) and the opening direction of the slot (80a) of the rod portion (80) are substantially matched. And the gasket (68) and the pusher (70) are connected by inserting the anti-rotation protrusion (21) into the anti-rotation groove (20). A connection step of obtaining a solid (10C);
    Disposing the barrel assembly (10B, 10C) in the housing (74) such that the lead screw (88) is inserted into the slot (80a) of the rod portion (80). ,
    A method for assembling the drug solution administration device (56).
PCT/JP2018/010999 2017-03-30 2018-03-20 Barrel assembly, method of using syringe, medicinal liquid injection apparatus, and assembly method thereof WO2018180758A1 (en)

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JP2022524197A (en) * 2019-03-11 2022-04-28 ニコベンチャーズ トレーディング リミテッド Aerosol supply device

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WO2014045393A1 (en) * 2012-09-21 2014-03-27 テルモ株式会社 Syringe gasket

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