WO2018151567A1 - Toothpaste composition comprising jade component - Google Patents

Toothpaste composition comprising jade component Download PDF

Info

Publication number
WO2018151567A1
WO2018151567A1 PCT/KR2018/002021 KR2018002021W WO2018151567A1 WO 2018151567 A1 WO2018151567 A1 WO 2018151567A1 KR 2018002021 W KR2018002021 W KR 2018002021W WO 2018151567 A1 WO2018151567 A1 WO 2018151567A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
jade
toothpaste composition
extract
abrasive
Prior art date
Application number
PCT/KR2018/002021
Other languages
French (fr)
Korean (ko)
Inventor
최미경
Original Assignee
최미경
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 최미경 filed Critical 최미경
Publication of WO2018151567A1 publication Critical patent/WO2018151567A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a toothpaste composition comprising the jade component.
  • oral hygiene can be classified into toothpaste, dentifrice, film and spray.
  • the purpose of the use of these oral products includes aesthetics such as whitening of the mouth, prevention of tartar deposition, suppression of bad breath, and treatment and prevention of tooth decay and gum disease.
  • Toothpaste is a drug compound used on a toothbrush for the purpose of cleaning and polishing teeth. It consists of powder, cream, liquid, and the like. Toothpaste is made to help disinfection, tartar disintegration, odor reduction, and prevention or treatment of tooth decay or alveolar pylori.
  • an abrasive may be mentioned first.
  • the abrasive calcium carbonate, calcium phosphate, calcium sulfate, magnesium carbonate, magnesium chloride and the like are used. These are helpful for the mechanical cleaning of the teeth. If the size, hardness, and shape of the particles are not appropriate, they may damage the surface of the teeth. Therefore, the size of the particles should be about 1 to 20 ⁇ m, and the shape may be too large. It is required not to be sensitive or to have a firmness of about 3 degrees of morse.
  • a cleaning agent, a flavoring agent, a coloring agent, a disinfectant disinfectant, a tartar dissolving agent, a neutralizing agent and the like are mixed little by little in addition to the abrasive.
  • a binder, a stabilizer and the like are added.
  • toothpastes containing certain substances such as bamboo salt, antiplasmin, allantoin derivatives, vitamin esters, elvan, mica, and ceramics have been developed to increase the antiseptic power for preventing oral antibacterial and inflammation in the oral cavity. It is included.
  • the present invention has been made to solve the above disadvantages of the prior art
  • an object of the present invention is to provide a dentifrice composition which provides a very good effect, such as toothache, periodontitis, bad breath by including an effective drug active ingredient.
  • an object of this invention is to provide the toothpaste composition excellent in an aesthetic sense.
  • an object of the present invention is to provide a dentifrice composition which can effectively prevent the precipitation of the jade powder which may occur by containing the jade powder.
  • Toothpaste composition of the present invention by including various types of jade component, not only improve the efficacy of the toothpaste by the jade component itself, but also enhance the activity of other active ingredients by the effect of far-infrared rays, etc. emitted from the jade component toothache, It provides a very good effect on periodontitis, bad breath, etc.
  • the toothpaste composition of the present invention provides an excellent effect, such as toothache, periodontitis, bad breath by including an effective drug active ingredient.
  • the toothpaste composition of the present invention provides an excellent aesthetic.
  • the toothpaste composition of the present invention is very excellent in storage stability by effectively preventing the precipitation of the jade powder which may occur by containing the jade powder.
  • the present invention is 20 to 40% by weight of the abrasive; 20 to 40% by weight of a humectant, including an aqueous sorbitol solution and glycerin; 1 to 10% by weight of a binder including xanthan gum and carboxymethylcellulose sodium; 0.5 to 3 weight percent of a surfactant including sodium N-lauroyl glutamate; 0.1 to 2 wt% sweetener including stevioside; 0.01-2% by weight of fragrance containing peppermint oil; 10 to 25% by weight of an active ingredient comprising allantoinchlorohydroxyaluminum, aminocaproic acid, xylitol, fish herb extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic; It relates to a toothpaste composition comprising; and a residual amount of natural alkali reduced water of pH 7.5 ⁇ 8.5.
  • step (b) cooling the salt baked in step (a) to room temperature
  • the enzyme solution is not particularly limited, and as a known enzyme solution, an enzyme that helps oral health may be used without limitation.
  • Natural alkali reduced water of pH 7.5 ⁇ 8.5 in the step (d) can be used those described in detail below.
  • the ripening period is not particularly limited, and for example, one week to three years may be aged at an appropriate period.
  • the enzyme solution and the natural alkaline reduced water of pH 7.5 ⁇ 8.5 may be sprayed in an amount of 2 to 10% by weight based on the total weight of salt, respectively.
  • the natural alkaline reduced water of pH 7.5 ⁇ 8.5 is preferably ground water produced in the jade mine area.
  • the groundwater produced in the jade mine area is characterized by mild water, sweet taste, and cleanness without poison (agreement).
  • the five viscera are rich, the wastes of the body escape, and the hair does not whiten (herb).
  • Chinese people have long been known to drain jade because they have a direct effect on the human body, stabilizing nerves and strengthening the function of the five intestines.
  • Alkali-reduced water in Korea or Japan is also divided into alkaline water made through ionized water.
  • Alkaline water is effective in chronic diarrhea, gastritis, excessive stomach acid, indigestion, gastrointestinal fermentation, constipation, fatigue reduction, cold prevention, anorexia recovery, hypertension, diabetes, allergies, rheumatism, excessive hangover, asthma, urticaria.
  • the natural alkali reduced water is more preferably pH of 8.0 ⁇ 8.5.
  • the abrasive may include 20 to 70 wt% of jade powder and 30 to 80 wt% of silicon dioxide based on the total weight of the abrasive.
  • the jade powder has an average particle size of 100 to 400 mesh, the surface of which is coated with a silane compound of Formula 1 may be preferably used:
  • Jade powder is a polishing action to remove tartar and plaque attached to teeth. It is used for remineralization, whitening and dental caries prevention of teeth. In addition, the jade powder also provides the effect of making the oral cavity healthy by smoothing the blood circulation of the gums at the time of brushing by the blood circulation promoting action.
  • jade powder is made to be enlightened, and when taken, it enriches the five intestines and discharges waste products in the body, and removes the heat of the stomach, which is effective for the digestive system. It is said to lubricate the function, assist in the vocal cords, and is said to be good for the throat.
  • Jade is distinguished by difference in mineral color and hardness and is roughly divided into Jadeite and Nephrite.
  • Mainly used for health promotion and disease treatment, purgatory is Xinjiang Purgatory in China, which has been used for the treatment of various diseases since ancient times, and this purplish is tussumstone or tungstenite, which is composed of fine fibrous crystals and forms a dense mass.
  • nephrite powder having a low hardness in the jade powder with specific gravity of 2.9 to 3.0 and hardness of 5.5 to 6.0, and the degree of polishing of the final product produced using such jade powder is It has a value of 250 or less as measured by a radiographic tooth wear measurement method adopted as a standard method in the United States or United Kingdom.
  • the average particle size of the jade powder is preferably from 100 to 400 mesh, it is not preferable because it does not perform a function as an abrasive, or the roughness of the product is severe.
  • the jade powder is preferable because it can be produced using a lead treated with residue or waste derived from mining or jewelry processing.
  • Jade powder is included in the toothpaste to provide an excellent effect as described above, but has a disadvantage that does not go to the bottom because the density is larger than the other components.
  • the surface of the jade powder is used by coating with a silane compound.
  • the coating by the silane compound on the surface of the jade powder is prepared in the form of a slurry by stirring the jade powder in water, by adding and stirring the silane compound represented by the formula (1) to the slurry, by stirring to remove water Can be performed.
  • the silane compound represented by the following Chemical Formula 1 is preferably added in an amount of 5 to 20 parts by weight based on 100 parts by weight of the jade powder, and the stirring is preferably performed very strongly.
  • silane compound represented by Formula 1 three methoxy groups bonded to Si are changed to three hydroxy groups in a slurry, and the three hydroxy groups are firmly bonded to the surface of the jade powder.
  • succinic anhydride is cleaved in the slurry and converted into two carboxyl groups.
  • the two carboxyl groups are hydrophilic groups that are well mixed with water in the toothpaste so that the jade powder can be dispersed well.
  • Toothpaste composition of the present invention may further comprise 0.1 to 3% by weight of a brightener containing titanium oxide.
  • the toothpaste composition of the present invention may further include a fluorine component, and as the fluorine component, sodium fluoride, sodium fluorophosphate, tin fluoride, amine fluoride, etc. may be used, and these may be used alone or in combination. More than one species can be mixed and used at a concentration of 500 to 1,500 ppm.
  • additives generally used in dentifrice compositions may be used without limitation, without departing from the object of the present invention.
  • potassium nitrate, tricalcium phosphate (syringe relieving), sodium lauryl sulfate (foaming agent) and the like may further be used.
  • Toothpaste composition of the present invention by adjusting the pH to 7.0 to 8.5 to provide a toothpaste composition more excellent in suppressing the avir
  • the abrasive may include 20 to 70 wt% of jade powder and 30 to 80 wt% of silicon dioxide based on the total weight of the abrasive.
  • the composition of the abrasive should be adjusted in view of the polishing force, efficacy and effect of the tooth.
  • the abrasive is included in 20 to 40% by weight.
  • the humectant is used to prevent dry evaporation of the ointment toothpaste by inhibiting evaporation of moisture when the toothpaste is exposed to air, and includes an aqueous solution of sorbitol and glycerin and is included in an amount of 20 to 40 wt%.
  • the binder is combined with a liquid component of the toothpaste component and a solid component such as an abrasive to maintain an ointment, prevent the separation of the liquid component and to formulate a viscosity suitable for use.
  • the binder includes xanthan gum and carboxymethylcellulose sodium and is included in an amount of 1 to 10% by weight.
  • the foaming agent serves to complement the cleaning action of the abrasive and to generate bubbles to increase the brushing feeling.
  • the foaming agent includes sodium N-lauroyl glutamate and is contained in 0.5 to 3% by weight.
  • flavors and sweeteners are used to enhance brushing, and flavorants including peppermint oil and sweeteners including stevioside are used.
  • the fragrance and sweetener are included in 0.01 to 2% by weight and 0.1 to 2% by weight, respectively.
  • the present invention also provides a pharmaceutical composition
  • a pharmaceutical composition comprising allantoin chlorohydroxyaluminum, aminocaproic acid, xylitol, fish vinegar extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic. 25 wt%.
  • the allantoin chlorohydroxyaluminum, aminocaproic acid, xylitol, fish vinegar extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic are 1 to 3: 1 to 3: 1 to 1, respectively.
  • the allantoin chlorohydroxyaluminum and aminocaproic acid are used as an anti-inflammatory and periodontal disease prevention agent.
  • the xylitol has a unique pentose structure that can not decompose the decay bacteria have a function to reduce the occurrence of caries.
  • mutans bacteria which are representative tooth decay bacteria
  • xylitol which is similar to sugar, to be eaten as sugar.
  • Xylitol is not digested by caries, which does not produce acid, which is a cause of tooth damage.
  • all of the energy is weakened and activity is weakened, which can suppress the growth of caries, reduce the formation of plaque, a bacterial membrane on the surface of the tooth, and prevent the production of acids by reducing the formation of cavities.
  • the Echochocho extract is effective in removing inflammation and acts to increase the effect of removing bacteria causing gum disease.
  • the ginseng extract is added to have an anti-inflammatory function, such as bamboo salt and aminocapronic acid, the ginseng has a component called matrine to activate the peristalsis of the intestine, especially used for eczema or skin purulent, warts, boils, scabies, etc. Used to get rid of pain and itching caused by it.
  • the main antimicrobial material of the grapefruit seed extract is naringin and citral.
  • Naringin is a flavonoid known as vitamin P. It is found in the skin and seeds of ripe grapefruit. Naringin has a bitter taste, and the molecular formula is C 27 H 32 0 14 ⁇ 2H 2 O.
  • the green tea extract mainly contains components such as caffeine, organic acids, amino acids, (+)-catechin, sugars, and the like, and (+)-catechin having a three-dimensional structure of a polyaryl phenol derivative among these components. By action, the bad breath is continuously suppressed.
  • green tea extract has excellent anti-inflammatory and antibacterial effects against swelling at the inflammatory site, and excellent cell protection effect, which is excellent for anti-aging effect of the skin and inhibits the development of cancer by acting on animal cancer cells. It is known to have antimutagenic effects.
  • the myrrh is a fragrant scabbard and vegetable preservative that is hardened by scarring or spontaneously flowing down the tree trunk of the myrrh.
  • Myrrh is mainly used for infections of the oral cavity. It has antibacterial effect and is also used as astringent, puncture agent, and antagonist.
  • the jade enzyme salt is used as a component for preventing periodontal disease such as gingivitis and periodontitis.
  • the aloe vera gel is known to have antioxidant activity, antibacterial action, anti-tumor action, bactericidal action, anti-inflammatory action, tissue formation action and the like.
  • the mastic is an evergreen shrub of the family Sumac and grows 2 to 3 meters in height and grows very slowly until 40-50 years later. It also produces gum from five-year-old trees. Mastic trees live for over 100 years, but begin to age in about 70 years. Only Chia species, cultivated exclusively in the southern part of the Greek island of Chios, produce pure and unique top-quality gum mastic. It is listed worldwide in the list of official drugs in 25 countries around the world, including the British Pharmacopoeia (BP) and European Pharmacopoeia (EP), and is widely used as a traditional medicine in many countries. With scientific research in modern times, helicobacter has been increasingly utilized in various forms such as gum, toothpaste, spa and cosmetics for gastrointestinal health. Mastic has excellent efficacy on periodontal disease, and specifically inhibits the development of 6 caries, and 5 periodontal pathogens, and is effective in periodontitis and gingivitis.
  • BP British Pharmacopoeia
  • EP European Pharmacopoeia
  • nephrite powder having an average particle size of 250 to 280 mesh was dispersed in water to prepare a slurry, and 40 g of the silane compound represented by the following Chemical Formula 1 was added thereto, followed by reaction for 1 hour while stirring. After the reaction was completed, water was removed from the slurry to prepare an jade powder coated with a silane compound.
  • the toothpaste composition of Examples 1 to 2 and the toothpaste composition of Comparative Example 1 according to the present invention were prepared by the following method.
  • the binder was added to the humectant, diluted with alkaline reduced water, which is ground water produced in the jade mine area at pH 8.2, and mixed firstly using a mixer, followed by the addition of an abrasive, an active ingredient, a sweetener, and a flavoring agent for 30 minutes. After mixing, the surfactant was added thereto and mixed to prepare a toothpaste composition.
  • alkaline reduced water which is ground water produced in the jade mine area at pH 8.2
  • Example 1 Example 2 Comparative Example 1 Comparative Example 2 Surface-coated jade powder (Preparation 1) 15 15 - 15 (uncoated jade powder) Silicon dioxide 10 10 25 10 Sorbitol aqueous solution (70%) 15 15 15 15 glycerin 10 10 10 10 Xanthan Gum One One One One One One Carboxymethyl Cellulose Sodium One One One One Sodium N-lauroyl glutamate 2 2 2 2 Stevioside One One One One One One Peppermint oil 1.5 One 1.5 1.5 1.5 Allantoinchlorohydroxyaluminum 2 2 2 2 2 2 Stevioside One One One One One One Peppermint oil 1.5 One 1.5 1.5 1.5 Allantoinchlorohydroxyaluminum 2 2 2 2 2 2 Aminocaproic acid 1.5 1.5 1.5 1.5 1.5 Xylitol 1.5 1.5 1.5 1.5 1.5 1.5 Eoseongcho Extract 2 1.5 2 2 Red ginseng extract 1.5 1.5 1.5 1.5 1.5 Grapefruit Seed Extract 1.5 One 1.5 1.5 Green Tea Extract 2 2 2 2 Myrrh 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Jade
  • the toothpaste composition of Comparative Example 1 containing purified water instead of alkaline reduced water was used for 15 adult men and women who complained of the symptoms of periodontitis (5), toothache (5), bad breath (5), and 3 per day. Blind test was performed to keep using 30 times each time. Subjects were given scores according to the following criteria and the scores were averaged to assess the degree of improvement of the symptoms and the results are shown in Table 2 below.
  • Example 1 Comparative Example 1 toothache 4.1 3.2 Periodontitis 4.3 3.0 Bad breath 4.0 3.2 Taste ⁇ ⁇
  • Example 1 of the present invention containing jade powder, jade enzyme salt, and pH 8.2 alkaline reduced water collected around the jade mine showed a very good improvement effect against toothache, periodontitis and bad breath.
  • the toothpaste composition of Comparative Example 1 including silicon dioxide, bamboo salt and purified water was confirmed to some extent, but showed a clearly insufficient effect than Example 1.
  • Example 1 of the present invention is superior to the toothpaste composition of Comparative Example 1.
  • Test Example 2 Comparative evaluation of the stability of the toothpaste composition
  • Example 1 The toothpaste composition of Example 1 was stored at room temperature, and after 1, 2, 4, and 8 months, the properties of the stored toothpaste composition were observed to evaluate the stability over time based on the following criteria, and the results are shown in Table 3 below.
  • Example 1 Comparative Example 2 1 month storage ⁇ ⁇ 2 months storage ⁇ ⁇ 4 months storage ⁇ ⁇ 8 months storage ⁇ ⁇
  • the dentifrice composition of Example 1 using the jade powder coated with the silane compound represented by the formula (1) is excellent in the stability of the dentifrice composition because no separation of the phase separation and purifying jade powder
  • the composition of Comparative Example 2 using the uncoated jade powder was found after two months of phenomena in which the jade was deposited on the bottom.
  • test results indicate that the silane compound represented by Formula 1 included in the dentifrice composition of the present invention performs a function of stably dispersing the nephrite powder, thereby preventing the nephrite powder from being precipitated.

Abstract

The present invention provides a toothpaste composition comprising: 20-40 wt% of an abrasive; 20-40 wt% of a wetting agent comprising a sorbitol aqueous solution and glycerin; 1-10 wt% of a binder comprising xanthan gum and sodium carboxymethylcellulose; 0.1-5 wt% of a surfactant comprising sodium N-lauroyl glutamate; 0.1-2 wt% of a sweetener comprising stevioside; 0.01-2 wt% of a flavoring comprising peppermint oil; 10-25 wt% of medicinal components comprising allantoin chlorohydroxy aluminum, aminocaproic acid, xylitol, a Houttuynia cordata extract, a Sophora flavescens extract, a grapefruit seed extract, a green tea extract, myrrh, jade enzyme salt, an aloe vera gel, and mastic; and the balance natural alkaline reduced water of pH 7.5-8.5.

Description

옥 성분을 포함하는 치약 조성물Toothpaste composition containing jade component
본 발명은 옥 성분을 포함하는 치약 조성물에 관한 것이다. The present invention relates to a toothpaste composition comprising the jade component.
일반적인 구강 위생제의 종류는 치약, 양치액, 필름 및 스프레이 등으로 분류할 수 있다. 이들 구강용품의 사용 목적에는 구강의 미백, 치석 침착 예방, 구취 억제 등 심미적인 것과, 충치나 잇몸질환의 치료 및 예방과 같은 것이 있다.Common types of oral hygiene can be classified into toothpaste, dentifrice, film and spray. The purpose of the use of these oral products includes aesthetics such as whitening of the mouth, prevention of tartar deposition, suppression of bad breath, and treatment and prevention of tooth decay and gum disease.
치약은 치아를 청결하게 하고 연마할 목적으로 칫솔에 묻혀 사용하는 약물성 복합물질로서, 분말, 크림, 액상 등으로 되어 있다. 치약은 소독작용, 치석용해작용, 냄새감퇴작용 및 충치나 치조농루 등의 예방 또는 치료에 도움이 되도록 만들어진다. Toothpaste is a drug compound used on a toothbrush for the purpose of cleaning and polishing teeth. It consists of powder, cream, liquid, and the like. Toothpaste is made to help disinfection, tartar disintegration, odor reduction, and prevention or treatment of tooth decay or alveolar pylori.
치약의 구성성분으로는 먼저 연마제를 들 수 있다. 연마제로는 탄산칼슘, 인산칼슘, 황산칼슘, 탄산마그네슘, 염화마그네슘 등이 사용된다. 이들은 치아의 기계적 청소에 도움이 되는 것인데, 그 입자의 크기, 경도, 모양이 적당하지 않으면 치아의 표면을 손상시킬 우려가 있으므로, 입자의 크기는 대략 1 내지 20 ㎛으로서 균일할 것, 형태는 너무 예민하지 않을 것, 굳기는 모스 굳기 3도 정도일 것 등이 요구된다.As a component of the toothpaste, an abrasive may be mentioned first. As the abrasive, calcium carbonate, calcium phosphate, calcium sulfate, magnesium carbonate, magnesium chloride and the like are used. These are helpful for the mechanical cleaning of the teeth. If the size, hardness, and shape of the particles are not appropriate, they may damage the surface of the teeth. Therefore, the size of the particles should be about 1 to 20 μm, and the shape may be too large. It is required not to be sensitive or to have a firmness of about 3 degrees of morse.
치약에는 상기 연마제 외에 청정제, 향료, 색소, 살균소독제, 치석용해제, 중화제 등이 조금씩 혼입된다. 크림 타입에는 이외에도 접합제, 안정제 등이 첨가된다.In the toothpaste, a cleaning agent, a flavoring agent, a coloring agent, a disinfectant disinfectant, a tartar dissolving agent, a neutralizing agent and the like are mixed little by little in addition to the abrasive. In addition to the cream type, a binder, a stabilizer and the like are added.
근래에는 구강내의 항균 및 염증 예방을 위한 살균력을 높이기 위하여 특정의 물질, 예컨대 죽염, 항플라스민제, 알란토인 유도체, 비타민 에스테르, 맥반석이나 운모, 세라믹을 함유시킨 치약들이 개발되고 있으며, 다양한 생약성분들도 포함되고 있다. Recently, toothpastes containing certain substances such as bamboo salt, antiplasmin, allantoin derivatives, vitamin esters, elvan, mica, and ceramics have been developed to increase the antiseptic power for preventing oral antibacterial and inflammation in the oral cavity. It is included.
그러나, 상기 성분들의 포함에 의해서도 기대만큼의 효과는 얻어지고 있지 못한 실정이다.However, even the inclusion of the above components has not been as effective as expected.
본 발명은, 종래기술의 상기와 같은 단점을 해결하기 위하여 안출된 것으로서,The present invention has been made to solve the above disadvantages of the prior art,
다양한 형태의 옥 성분을 포함함으로써, 옥 성분 자체에 의한 효능을 향상시킬 뿐만 아니라, 옥 성분으로부터 방사되는 원적외선 등의 효과에 의해 다른 약효성분들의 활성도 강화시킬 수 있는 치약 조성물을 제공하는 것을 목적으로 한다.It is an object of the present invention to provide a dentifrice composition capable of enhancing the activity of other medicinal ingredients by not only improving the efficacy by the jade component itself, but also enhancing the activity of the other active ingredients by the effect of far infrared rays emitted from the jade component. .
또한, 본 발명은 효과적인 약효성분을 포함함으로써 치통, 치주염, 구취 등에 매우 우수한 효과를 제공하는 치약 조성물을 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide a dentifrice composition which provides a very good effect, such as toothache, periodontitis, bad breath by including an effective drug active ingredient.
또한, 본 발명은 미감이 우수한 치약 조성물을 제공하는 것을 목적으로 한다. Moreover, an object of this invention is to provide the toothpaste composition excellent in an aesthetic sense.
또한, 본 발명은 옥분말의 함유에 의해서 발생할 수 있는 옥분말의 침전을 효과적으로 방지할 수 있는 치약 조성물을 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide a dentifrice composition which can effectively prevent the precipitation of the jade powder which may occur by containing the jade powder.
본 발명은, 상기 목적을 달성하기 위하여, The present invention, in order to achieve the above object,
연마제 20~40 중량%; 솔비톨 수용액 및 글리세린을 포함하는 습윤제 20~40 중량%; 잔탄검 및 카르복시메틸셀룰로오스나트륨을 포함하는 결합제 1~10 중량%; N-라우로일글루타민산나트륨을 포함하는 계면활성제 0.1~5 중량%; 스데비오사이드를 포함하는 감미제 0.1~2 중량%; 페파민트유를 포함하는 향료 0.01~2 중량%; 알란토인클로로히드록시알루미늄, 아미노카프로산, 자일리톨, 어성초추출물, 고삼추출물, 자몽종자추출물, 녹차추출물, 몰약, 옥 효소 소금, 알로에베라겔, 및 메스틱을 포함하는 약효성분 10~25 중량%; 및 잔량의 pH 7.5~8.5의 천연 알칼리환원수;를 포함하는 치약 조성물을 제공한다. Abrasive 20-40% by weight; 20 to 40% by weight of a humectant, including an aqueous sorbitol solution and glycerin; 1 to 10% by weight of a binder including xanthan gum and carboxymethylcellulose sodium; 0.1-5% by weight of a surfactant comprising sodium N-lauroyl glutamate; 0.1 to 2 wt% sweetener including stevioside; 0.01-2% by weight of fragrance containing peppermint oil; 10 to 25% by weight of an active ingredient comprising allantoinchlorohydroxyaluminum, aminocaproic acid, xylitol, fish herb extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic; It provides a toothpaste composition comprising; and a residual amount of natural alkali reduced water of pH 7.5 ~ 8.5.
본 발명의 치약 조성물은 다양한 형태의 옥 성분을 포함함으로써, 옥 성분 자체에 의한 치약의 효능을 향상시킬 뿐만 아니라, 옥 성분으로부터 방사되는 원적외선 등의 효과에 의해 다른 약효성분들의 활성도 강화되기 때문에 치통, 치주염, 구취 등에 매우 우수한 효과를 제공한다. Toothpaste composition of the present invention by including various types of jade component, not only improve the efficacy of the toothpaste by the jade component itself, but also enhance the activity of other active ingredients by the effect of far-infrared rays, etc. emitted from the jade component toothache, It provides a very good effect on periodontitis, bad breath, etc.
또한, 본 발명의 치약 조성물은 효과적인 약효성분을 포함함으로써 치통, 치주염, 구취 등에 매우 우수한 효과를 제공한다. In addition, the toothpaste composition of the present invention provides an excellent effect, such as toothache, periodontitis, bad breath by including an effective drug active ingredient.
또한, 본 발명의 치약 조성물은 우수한 미감을 제공한다.In addition, the toothpaste composition of the present invention provides an excellent aesthetic.
또한, 본 발명의 치약 조성물은 옥분말의 함유에 의해서 발생할 수 있는 옥분말의 침전을 효과적으로 방지함으로써 보관 안정성이 매우 우수하다.In addition, the toothpaste composition of the present invention is very excellent in storage stability by effectively preventing the precipitation of the jade powder which may occur by containing the jade powder.
이하에서 본 발명을 자세히 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 연마제 20~40 중량%; 솔비톨 수용액 및 글리세린을 포함하는 습윤제 20~40 중량%; 잔탄검 및 카르복시메틸셀룰로오스나트륨을 포함하는 결합제 1~10 중량%; N-라우로일글루타민산나트륨을 포함하는 계면활성제 0.5~3 중량%; 스데비오사이드를 포함하는 감미제 0.1~2 중량%; 페파민트유를 포함하는 향료 0.01~2 중량%; 알란토인클로로히드록시알루미늄, 아미노카프로산, 자일리톨, 어성초추출물, 고삼추출물, 자몽종자추출물, 녹차추출물, 몰약, 옥 효소 소금, 알로에베라겔, 및 메스틱을 포함하는 약효성분 10~25 중량%; 및 잔량의 pH 7.5~8.5의 천연 알칼리환원수;를 포함하는 치약 조성물에 관한 것이다. The present invention is 20 to 40% by weight of the abrasive; 20 to 40% by weight of a humectant, including an aqueous sorbitol solution and glycerin; 1 to 10% by weight of a binder including xanthan gum and carboxymethylcellulose sodium; 0.5 to 3 weight percent of a surfactant including sodium N-lauroyl glutamate; 0.1 to 2 wt% sweetener including stevioside; 0.01-2% by weight of fragrance containing peppermint oil; 10 to 25% by weight of an active ingredient comprising allantoinchlorohydroxyaluminum, aminocaproic acid, xylitol, fish herb extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic; It relates to a toothpaste composition comprising; and a residual amount of natural alkali reduced water of pH 7.5 ~ 8.5.
상기에서 옥 효소 소금은 In the above jade enzyme salt
(a) 천일염을 1~2시간 굽는 단계;(a) baking the sun salt for 1 to 2 hours;
(b) 상기 (a)단계에서 구워진 소금을 상온으로 냉각시키는 단계;(b) cooling the salt baked in step (a) to room temperature;
(c) 상기 냉각된 소금에 효소액을 분무하고 건조시키는 단계;(c) spraying and drying an enzyme solution on the cooled salt;
(d) 상기 효소액이 분무된 소금에 7.5~8.5의 천연 알칼리환원수를 분무하고 건조하는 단계;(d) spraying and drying 7.5-8.5 natural alkaline reduced water to the salt sprayed with the enzyme solution;
(e) 상기 단계에서 제조된 소금을 숙성시키는 단계; 및(e) aging the salt prepared in the step; And
(f) 상기 숙성된 소금을 분쇄하는 단계;를 포함하여 제조된다.(f) pulverizing the aged salt; is prepared.
상기 (c)단계에서, 효소액은 특별히 한정되지 않으며, 공지된 효소액으로서 구강 건강에 도움이되는 효소는 제한 없이 사용될 수 있다.In the step (c), the enzyme solution is not particularly limited, and as a known enzyme solution, an enzyme that helps oral health may be used without limitation.
상기 (d)단계에서 pH 7.5~8.5의 천연 알칼리환원수는 하기에 자세히 기술된 것을 사용될 수 있다. Natural alkali reduced water of pH 7.5 ~ 8.5 in the step (d) can be used those described in detail below.
상기 (e)단계에서 숙성 기간은 특별히 한정되지 않으며 예를 들어, 1주에서 3년까지 적절한 기간으로 숙성시킬 수 있다.In the step (e), the ripening period is not particularly limited, and for example, one week to three years may be aged at an appropriate period.
상기 효소액과 pH 7.5~8.5의 천연 알칼리환원수는 각각 소금 총 중량에 대하여 2~10 중량%의 양으로 분무될 수 있다.The enzyme solution and the natural alkaline reduced water of pH 7.5 ~ 8.5 may be sprayed in an amount of 2 to 10% by weight based on the total weight of salt, respectively.
상기 pH 7.5~8.5의 천연 알칼리환원수는 옥광산 지역에서 생산되는 지하수인 것이 바람직하다. 상기 옥광산 지역에서 생산되는 지하수는 물의 성질이 온순하고 맛이 달며 깨끗해서 독이 없는 특징을 갖는다(동의보감). 또한, 사람들이 오랫동안 먹으면 오장육부가 윤택해지고 체내의 노폐물이 빠져나가며, 머리털이 희어지지 않는다고 한다(본초강목). 중국 사람들은 예로부터 옥을 귀하게 여겨 늘 몸에 지지고 다니는 것으로 알려졌는데, 이는 인체에 직접적인 영향을 미쳐서 신경을 안정시키고 오장육부의 기능 강화에 효과가 있기 때문이라고 한다. The natural alkaline reduced water of pH 7.5 ~ 8.5 is preferably ground water produced in the jade mine area. The groundwater produced in the jade mine area is characterized by mild water, sweet taste, and cleanness without poison (agreement). In addition, if people eat for a long time, the five viscera are rich, the wastes of the body escape, and the hair does not whiten (herb). Chinese people have long been known to cherish jade because they have a direct effect on the human body, stabilizing nerves and strengthening the function of the five intestines.
천연 알칼리환원수는 전세계적으로 희귀한 물로 학계에 조차 잘 알려져 있지 않은 물이다. 국내 혹은 일본에서도 알칼리환원수라 하면 보통 이온수기를 통해 만들어진 알칼리수로 구분한다. 알칼리수는 만성설사, 위염, 위산과다, 소화불량, 위장내 이상발효, 변비, 피로감해소, 감기예방, 식욕부진 회복, 고혈압, 당뇨, 알레르기, 류머티즘, 과음숙취해소, 천식, 두드러기에 효과가 있다.Natural alkali reduced water is rare in the world and is not well known even in academia. Alkali-reduced water in Korea or Japan is also divided into alkaline water made through ionized water. Alkaline water is effective in chronic diarrhea, gastritis, excessive stomach acid, indigestion, gastrointestinal fermentation, constipation, fatigue reduction, cold prevention, anorexia recovery, hypertension, diabetes, allergies, rheumatism, excessive hangover, asthma, urticaria.
상기에서 천연 알칼리환원수는 pH가 8.0~8.5인 것이 더욱 바람직하다. In the above, the natural alkali reduced water is more preferably pH of 8.0 ~ 8.5.
상기 연마제는 연마제 총 중량에 대하여 20~70 중량%의 옥분말과 이산화규소 30~80 중량%를 포함할 수 있다. 상기 옥분말은 평균입자크기가 100 ∼∼ 400 메쉬이며, 하기 화학식 1의 실란화합물로 표면이 코팅처리된 것이 바람직하게 사용될 수 있다:The abrasive may include 20 to 70 wt% of jade powder and 30 to 80 wt% of silicon dioxide based on the total weight of the abrasive. The jade powder has an average particle size of 100 to 400 mesh, the surface of which is coated with a silane compound of Formula 1 may be preferably used:
[화학식 1][Formula 1]
Figure PCTKR2018002021-appb-I000001
Figure PCTKR2018002021-appb-I000001
옥분말은 치아에 붙어 있는 치석과 치태를 제거하는 연마작용으로 치아의 재석회화나 미백효과 및 충치예방효과를 위해서 사용된다. 또한, 옥분말은 상기 효과 이외에 혈행 촉진작용에 의하여 양치시에 잇몸의 혈행을 원활하도록 함으로써 구강을 건강하게 할 수 있는 효과도 제공한다. 한편, 동의보감에 의하면 옥가루를 깨알만하게 만들어 복용하면 오장육부를 윤택하게 하고 체내에 노폐물을 배출시켜 주며 위장의 열을 제거해 소화계통에 효과가 있으며, 또한 옥가루를 장복하면 몸이 날아갈 듯 가벼워지고 폐장의 기능을 윤활하게 해주며 성대의 발성을 도와주고 인후에 좋은 것으로 기술되어 있다. 또한 신농본초, 본초강목에 의하면 얼굴, 몸 등에 상처자국이 있을 때 연옥 분말로 상처 부위를 수일간 문지르면 흉터가 없어지며 피부를 윤택하게 해주는 등 연옥의 주성분은 인체의 각 요소와 일치하여 부작용이 없이 인체에 탁월한 효능을 발휘하는 것으로 알려져 있다. 옥의 맛은 감미롭고 평온하며 독이 없으며 오장육부를 윤택하게 하고 체내의 노폐물을 배출시켜 주는 효과가 있다. 옥이 내는 원적외선은 인체의 혈액 순환을 왕성하게 하고 몸 속을 따뜻하게 열을 가해 주기 때문에 각종 성인병 예방에도 효과가 있다. 또한, 상기 원적외선은 치약 중의 다른 성분들의 활성을 극대화시키는 기능을 수행한다. Jade powder is a polishing action to remove tartar and plaque attached to teeth. It is used for remineralization, whitening and dental caries prevention of teeth. In addition, the jade powder also provides the effect of making the oral cavity healthy by smoothing the blood circulation of the gums at the time of brushing by the blood circulation promoting action. On the other hand, according to Dongbogam, jade powder is made to be enlightened, and when taken, it enriches the five intestines and discharges waste products in the body, and removes the heat of the stomach, which is effective for the digestive system. It is said to lubricate the function, assist in the vocal cords, and is said to be good for the throat. In addition, according to Xinonghuo Herb and Herbal Cortex, when rubbing scars on the face and body, rubbing the wound area with purgatory powder for several days, the scar disappears and the skin is moisturized. It is known to exert an excellent effect on the human body. The taste of jade is sweet, calm, non-toxic, and nourish the five gut meat and release the waste in the body. Far-infrared rays produced by jade are effective in preventing various adult diseases because they stimulate the human blood circulation and heat the body warmly. In addition, the far infrared serves to maximize the activity of the other ingredients in the toothpaste.
옥은 광물학상 색상과 굳기의 차이로 구분하며 경옥(Jadeite)과 연옥(Nephrite)으로 대별된다. 주로 건강증진과 질병치료에 사용되는 것은 연옥으로 중국의 신강성 연옥이 옛날부터 각종 질병의 치료에 사용되어왔으며, 이러한 연옥은 미세한 섬유상 결정이 얽혀 치밀질의 경괴를 이룬 투섬석 또는 투녹섬석이다. 따라서, 본 발명에서는 비중 2.9 ∼∼ 3.0, 굳기 5.5 ∼∼ 6.0으로 옥중에서 경도가 낮은 연옥(nephrite) 분말을 옥분말로 사용하는 것이 바람직하며, 이러한 옥분말을 사용하여 제조한 최종 제품의 연마도는 미국 또는 영국에서 표준 방법으로 채택하고 있는 방사선 표본 치아마모량 측정법으로 측정하여 250 이하의 값을 가진다. 그리고, 상기 옥분말의 평균입자크기는 100 ∼∼ 400 메쉬가 바람직하며, 상기 범위를 벗어나면 연마제로서 기능을 수행하지 못하거나, 제품의 거칠기가 심해져서 바람직하지 못하다.Jade is distinguished by difference in mineral color and hardness and is roughly divided into Jadeite and Nephrite. Mainly used for health promotion and disease treatment, purgatory is Xinjiang Purgatory in China, which has been used for the treatment of various diseases since ancient times, and this purplish is tussumstone or tungstenite, which is composed of fine fibrous crystals and forms a dense mass. Therefore, in the present invention, it is preferable to use nephrite powder having a low hardness in the jade powder with specific gravity of 2.9 to 3.0 and hardness of 5.5 to 6.0, and the degree of polishing of the final product produced using such jade powder is It has a value of 250 or less as measured by a radiographic tooth wear measurement method adopted as a standard method in the United States or United Kingdom. In addition, the average particle size of the jade powder is preferably from 100 to 400 mesh, it is not preferable because it does not perform a function as an abrasive, or the roughness of the product is severe.
상기 옥분말은 채광 시나 보석 세가공시에 파생되는 잔재 물 또는 폐기물로 처리되는 연을 사용하여 제조할 수 있어 바람직하다. The jade powder is preferable because it can be produced using a lead treated with residue or waste derived from mining or jewelry processing.
옥분말은 치약에 포함되어 상기와 같이 우수한 효과를 제공하지만, 다른 성분들보다 밀도가 크기 때문에 바닥으로 가라 않는 단점을 갖는다.Jade powder is included in the toothpaste to provide an excellent effect as described above, but has a disadvantage that does not go to the bottom because the density is larger than the other components.
그러므로 본 발명에서는 상기와 같은 단점을 해소하기 위하여, 옥분말의 표면을 실란화합물에 의해 코팅처리하여 사용한다. Therefore, in the present invention, in order to solve the above disadvantages, the surface of the jade powder is used by coating with a silane compound.
상기 옥분말 표면의 실란화합물에 의한 코팅은 옥분말을 물에 넣고 교반하여 슬러리 형태로 제조하고, 상기 슬러리에 상기 화학식 1로 표시되는 실란화합물을 첨가하고 교반한 후, 물을 제거하는 방법에 의하여 수행될 수 있다. The coating by the silane compound on the surface of the jade powder is prepared in the form of a slurry by stirring the jade powder in water, by adding and stirring the silane compound represented by the formula (1) to the slurry, by stirring to remove water Can be performed.
하기 화학식 1로 표시되는 실란화합물은 옥분말 100 중량부에 대하여 5~20 중량부로 첨가하는 것이 바람직하며, 상기 교반은 매우 강하게 수행하는 것이 바람직하다.The silane compound represented by the following Chemical Formula 1 is preferably added in an amount of 5 to 20 parts by weight based on 100 parts by weight of the jade powder, and the stirring is preferably performed very strongly.
[화학식 1][Formula 1]
Figure PCTKR2018002021-appb-I000002
Figure PCTKR2018002021-appb-I000002
상기 화학식 1로 표시되는 실란화합물은 Si에 결합된 3개의 메톡시기가 슬러리 중에서 3개의 하이드록시기로 변화되며, 상기 3개의 하이드록시기가 옥분말 표면에 견고하게 결합한다. 또한, 숙신산 언하이드라이드는 슬러리 중에서 개열되어 2개의 카르복실기로 변환된다. 상기 2개의 카르복실기는 친수성기로서 치약 내에서 물과 잘 혼합되어 옥분말이 잘 분산될 수 있게 한다.In the silane compound represented by Formula 1, three methoxy groups bonded to Si are changed to three hydroxy groups in a slurry, and the three hydroxy groups are firmly bonded to the surface of the jade powder. In addition, succinic anhydride is cleaved in the slurry and converted into two carboxyl groups. The two carboxyl groups are hydrophilic groups that are well mixed with water in the toothpaste so that the jade powder can be dispersed well.
본 발명의 치약 조성물은 산화티탄을 포함하는 증백제 0.1~3 중량%를 더 포함할 수 있다. Toothpaste composition of the present invention may further comprise 0.1 to 3% by weight of a brightener containing titanium oxide.
또한, 본 발명의 치약 조성물은 이 밖에 불소성분을 더 포함할 수 있으며, 불소성분으로는 불화나트륨, 제1불화인산나트륨, 불화주석, 아민플루오라이드 등이 사용될 수 있으며, 이들은 1종 단독 또는 2종 이상을 혼합하여 500 내지 1,500 ppm의 농도로 사용할 수 있다. In addition, the toothpaste composition of the present invention may further include a fluorine component, and as the fluorine component, sodium fluoride, sodium fluorophosphate, tin fluoride, amine fluoride, etc. may be used, and these may be used alone or in combination. More than one species can be mixed and used at a concentration of 500 to 1,500 ppm.
상술된 성분 이외에도 본 발명의 목적에 위배되지 않는 범위 내에서 치약 조성물에 일반적으로 사용되는 첨가제가 제한 없이 사용될 수 있다. 예를 들어, 질산칼륨, 인산삼칼슘(시린 이 완화), 라우릴 황산나트륨(기포제) 등이 추가로 사용될 수 있다.In addition to the components described above, additives generally used in dentifrice compositions may be used without limitation, without departing from the object of the present invention. For example, potassium nitrate, tricalcium phosphate (syringe relieving), sodium lauryl sulfate (foaming agent) and the like may further be used.
본 발명의 치약 조성물은 pH를 7.0~8.5로 조정함으로써 시린이 억제에 더욱 우수한 치약 조성물을 제공한다Toothpaste composition of the present invention by adjusting the pH to 7.0 to 8.5 to provide a toothpaste composition more excellent in suppressing the avir
이하에서 치약 조성물의 약효성분에 대하여 자세히 설명한다.Hereinafter, the active ingredient of the toothpaste composition will be described in detail.
본 발명에서 연마제는 연마제 총 중량에 대하여 20~70 중량%의 옥분말과 이산화규소 30~80 중량%를 포함할 수 있다. 상기 연마제의 구성은 치아의 연마력, 효능 및 효과 등을 감안하여 조절하여야 한다. 본 발명의 치약 조성물에서 연마제는 20~40 중량%로 포함된다.In the present invention, the abrasive may include 20 to 70 wt% of jade powder and 30 to 80 wt% of silicon dioxide based on the total weight of the abrasive. The composition of the abrasive should be adjusted in view of the polishing force, efficacy and effect of the tooth. In the toothpaste composition of the present invention, the abrasive is included in 20 to 40% by weight.
본 발명에서 습윤제는 치약이 공기중에 노출될 때 수분증발을 억제해서 연고상의 치약이 건조 고화되는 것을 방지하기 위해 사용하며, 솔비톨 수용액 및 글리세린을 포함하며, 20~40 중량%로 포함된다.In the present invention, the humectant is used to prevent dry evaporation of the ointment toothpaste by inhibiting evaporation of moisture when the toothpaste is exposed to air, and includes an aqueous solution of sorbitol and glycerin and is included in an amount of 20 to 40 wt%.
본 발명에서 결합제는 치약의 성분 중 액체성분과 연마제 같은 고체 성분을 결합시켜 연고상을 유지시켜 주며 액체성분이 분리되는 것을 막아주고 사용에 적합한 점도를 형성시킬 목적으로 배합한다. 본 발명에서 결합제는 잔탄검 및 카르복시메틸셀룰로오스나트륨을 포함하며 1~10 중량%로 포함된다.In the present invention, the binder is combined with a liquid component of the toothpaste component and a solid component such as an abrasive to maintain an ointment, prevent the separation of the liquid component and to formulate a viscosity suitable for use. In the present invention, the binder includes xanthan gum and carboxymethylcellulose sodium and is included in an amount of 1 to 10% by weight.
본 발명에서 기포제는 연마제의 세정작용을 보완하고, 기포를 발생시켜 양치감을 증대시켜 주는 역할을 한다. 본 발명에서 기포제는 N-라우로일글루타민산나트륨을 포함하며 0.5~3 중량%로 포함된다. In the present invention, the foaming agent serves to complement the cleaning action of the abrasive and to generate bubbles to increase the brushing feeling. In the present invention, the foaming agent includes sodium N-lauroyl glutamate and is contained in 0.5 to 3% by weight.
또한 양치감을 증진시키기 위하여 향료 및 감미제를 사용하는데, 페파민트유를 포함하는 향료 및 스데비오사이드를 포함하는 감미제를 사용한다. 상기 향료 및 감미제는 각각 0.01~2 중량% 및 0.1~2 중량%로 포함된다. In addition, flavors and sweeteners are used to enhance brushing, and flavorants including peppermint oil and sweeteners including stevioside are used. The fragrance and sweetener are included in 0.01 to 2% by weight and 0.1 to 2% by weight, respectively.
본 발명은 또한, 알란토인클로로히드록시알루미늄, 아미노카프로산, 자일리톨, 어성초추출물, 고삼추출물, 자몽종자추출물, 녹차추출물, 몰약, 옥 효소 소금, 알로에베라겔, 및 메스틱을 포함하는 약효성분을 10~25 중량%로 포함한다.The present invention also provides a pharmaceutical composition comprising allantoin chlorohydroxyaluminum, aminocaproic acid, xylitol, fish vinegar extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic. 25 wt%.
상기 알란토인클로로히드록시알루미늄, 아미노카프로산, 자일리톨, 어성초추출물, 고삼추출물, 자몽종자추출물, 녹차추출물, 몰약, 옥 효소 소금, 알로에베라겔, 및 메스틱은 각각 1~3 : 1~3 : 1~3 : 1~3 : 1~3 : 1~3 : 1~3 : 1~3 : 1~3 : 1~3 : 1~3 의 중량비로 포함될 수 있다. The allantoin chlorohydroxyaluminum, aminocaproic acid, xylitol, fish vinegar extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic are 1 to 3: 1 to 3: 1 to 1, respectively. 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3
상기 알란토인클로로히드록시알루미늄 및 아미노카프로산은 염증완화제 및 치주질환예방제로 사용된다. The allantoin chlorohydroxyaluminum and aminocaproic acid are used as an anti-inflammatory and periodontal disease prevention agent.
상기 자일리톨은 충치균이 분해하지 못하는 독특한 5탄당 구조를 가지고 있어 충치 발생을 줄이는 기능을 갖고 있다. 구체적으로 예를 들면, 대표적인 충치 유발균인 뮤탄스균은 설탕과 비슷한 자일리톨을 설탕으로 착각하고 먹게 되는데, 자일리톨은 충치균에 의해 소화되지 않아 치아 손상의 원인인 산(acid)을 만들어 내지 못하고, 충치균이 자일리톨을 계속 먹는 과정에서 에너지를 모두 소비하게 되면서 활동이 약해져, 충치균의 성장을 억제하고 치아 표면의 세균막인 프라그 형성을 감소시키고, 산의 생성을 방해하여 충치 발생을 감소시킬 수 있다.The xylitol has a unique pentose structure that can not decompose the decay bacteria have a function to reduce the occurrence of caries. Specifically, for example, mutans bacteria, which are representative tooth decay bacteria, mistake xylitol, which is similar to sugar, to be eaten as sugar. Xylitol is not digested by caries, which does not produce acid, which is a cause of tooth damage. In the process of continuing to consume xylitol, all of the energy is weakened and activity is weakened, which can suppress the growth of caries, reduce the formation of plaque, a bacterial membrane on the surface of the tooth, and prevent the production of acids by reducing the formation of cavities.
상기 어성초추출물은 염증 제거에 효과가 있는 것으로서 잇몸 질환을 유발하는 세균을 제거하는 효과를 상승시키는 작용을 한다.The Echochocho extract is effective in removing inflammation and acts to increase the effect of removing bacteria causing gum disease.
상기 고삼추출물은 죽염 및 아미노카프론산과 같이 항염 기능을 갖도록 첨가하는 것인데, 고삼에는 마트린이라는 성분이 있어서 장의 연동 운동을 활발하게 하고, 특히 습진이나 피부 화농증에 많이 쓰이며 사마귀나 종기, 옴 등으로 인한 통증 및 가려움증을 없애는 데 사용된다.The ginseng extract is added to have an anti-inflammatory function, such as bamboo salt and aminocapronic acid, the ginseng has a component called matrine to activate the peristalsis of the intestine, especially used for eczema or skin purulent, warts, boils, scabies, etc. Used to get rid of pain and itching caused by it.
상기 자몽종자 추출물의 주요 항균물질은 나린진과 시트랄이라는 성분이다. 나린진은 비타민 P로 알려진 후라보노이드라는 성분으로 이 물질은 주로 잘 익은 자몽의 종자, 껍질에 많이 존재한다. 나린진은 쓴맛이 있으며, 분자식은 C27H32014ㆍ2H2O이다.The main antimicrobial material of the grapefruit seed extract is naringin and citral. Naringin is a flavonoid known as vitamin P. It is found in the skin and seeds of ripe grapefruit. Naringin has a bitter taste, and the molecular formula is C 27 H 32 0 14 ㆍ 2H 2 O.
상기 녹차추출물은 카페인을 비롯한 유기산, 아미노산, (+)-카테친(Catechin), 당류 등의 성분들을 주로 함유하고 있으며, 이들 성분 중 포릴페놀 유도체의 3차원적 구조를 갖는 (+)-카테친이 포접작용에 의해 지속적으로 구취를 억제시킨다.The green tea extract mainly contains components such as caffeine, organic acids, amino acids, (+)-catechin, sugars, and the like, and (+)-catechin having a three-dimensional structure of a polyaryl phenol derivative among these components. By action, the bad breath is continuously suppressed.
일반적으로 녹차추출물은 염증 부위에 부풀어 오르는 것을 억제하는 항염작용 및 각종균에 대한 항균작용이 우수하며, 세포 보호작용도 우수하여 피부의 노화방지 효과가 탁월하고 또한 동물 암세포에 작용하여 암발생 억제 및 항변이원성 효과를 가지는 것으로 알려져 있다.In general, green tea extract has excellent anti-inflammatory and antibacterial effects against swelling at the inflammatory site, and excellent cell protection effect, which is excellent for anti-aging effect of the skin and inhibits the development of cancer by acting on animal cancer cells. It is known to have antimutagenic effects.
또한, 고혈압을 유발하는 안지오텐신 전달 효소를 저해하고 혈소판을 이완시킴으로써 혈압을 강하시키는 작용도 하며, 그 외 혈중 콜레스테롤의 농도를 감소시켜 동맥경화를 억제하는 효과가 있는 것으로 알려져 있다.In addition, it inhibits angiotensin transfer enzymes that cause high blood pressure and relaxes platelets, thereby lowering blood pressure. In addition, it is known to have an effect of inhibiting arteriosclerosis by reducing the concentration of cholesterol in the blood.
상기 몰약은 몰약나무의 나무 줄기에 상처를 내거나 또는 저절로 흘러내려 굳어진 방향성의 나무진이며 식물성 방부제이다. 몰약은 주로 구강의 감염에 많이 쓰이며 항균작용이 있고 수렴제, 구풍제, 건위제로도 사용된다.The myrrh is a fragrant scabbard and vegetable preservative that is hardened by scarring or spontaneously flowing down the tree trunk of the myrrh. Myrrh is mainly used for infections of the oral cavity. It has antibacterial effect and is also used as astringent, puncture agent, and antagonist.
상기 옥 효소 소금은 치은염, 치주염 등의 치주 질환 예방 성분으로 사용된다. The jade enzyme salt is used as a component for preventing periodontal disease such as gingivitis and periodontitis.
상기 알로에베라겔은 항산화 활성, 항균 작용, 항종양 작용, 살균 작용, 소염 작용, 조직형성 작용 등이 있는 것으로 알려져 있다. The aloe vera gel is known to have antioxidant activity, antibacterial action, anti-tumor action, bactericidal action, anti-inflammatory action, tissue formation action and the like.
상기 메스틱은 옻나무과의 상록 관목으로 키가 2~3미터이고, 생장 속도가 아주 느려서 40~50년이 지나야 다 자라게 된다. 그리고 5년생 나무부터 껌을 생산해 낸다. 메스틱 나무는 100년이 넘도록 살지만 70년 정도되면 늙기 시작한다. 오직 그리스 키오스 섬의 남부에서만 독점적으로 재배되는 Chia 종만이 순수하고 독특한 최상급의 껌 메스틱을 생산해낸다. 전세계적으로 영국 약전(BP), 유럽 약전(EP) 등 세계 25개국의 공식 의약품 목록에 기재되어 있고, 여러 나라들에서 전통적인 의약품으로 널리 사용되고 있다. 현대에 와서 과학적으로 연구되면서 헬리코박터와 관련하여 위장 건강을 위한 껌, 치약, 스파, 화장품 등 다양한 형태로 그 활용도가 높아지고 있다. 메스틱은 치주질환에 효능이 우수하며, 구체적으로 충치원인균 6종과 치주병원균 5종에 대해 발육을 억제하며, 치주염 및 치은염에 효과가 있다. The mastic is an evergreen shrub of the family Sumac and grows 2 to 3 meters in height and grows very slowly until 40-50 years later. It also produces gum from five-year-old trees. Mastic trees live for over 100 years, but begin to age in about 70 years. Only Chia species, cultivated exclusively in the southern part of the Greek island of Chios, produce pure and unique top-quality gum mastic. It is listed worldwide in the list of official drugs in 25 countries around the world, including the British Pharmacopoeia (BP) and European Pharmacopoeia (EP), and is widely used as a traditional medicine in many countries. With scientific research in modern times, helicobacter has been increasingly utilized in various forms such as gum, toothpaste, spa and cosmetics for gastrointestinal health. Mastic has excellent efficacy on periodontal disease, and specifically inhibits the development of 6 caries, and 5 periodontal pathogens, and is effective in periodontitis and gingivitis.
이하에서, 실시예를 통하여 본 발명을 보다 상세히 설명한다. 그러나, 하기의 실시예는 본 발명을 더욱 구체적으로 설명하기 위한 것으로서, 본 발명의 범위가 하기의 실시예에 의하여 한정되는 것은 아니다. 하기의 실시예는 본 발명의 범위 내에서 당업자에 의해 적절히 수정, 변경될 수 있다. Hereinafter, the present invention will be described in more detail with reference to Examples. However, the following examples are intended to illustrate the present invention more specifically, but the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.
제조예 1: 실란 화합물로 표면이 코팅된 옥분말의 제조Preparation Example 1 Preparation of Ox Powder Coated with Silane Compound
평균입자크기가 250~280 메쉬인 연옥분말 500 g을 물에 분산시켜 슬러리 형태로 제조한 후, 하기 화학식 1로 표시되는 실란 화합물 40 g을 첨가하여 교반하면서 1시간 동안 반응시켰다. 반응이 완료된 후, 슬러리로부터 물을 제거하여 실란 화합물로 표면이 코팅된 옥분말을 제조하였다. 500 g of nephrite powder having an average particle size of 250 to 280 mesh was dispersed in water to prepare a slurry, and 40 g of the silane compound represented by the following Chemical Formula 1 was added thereto, followed by reaction for 1 hour while stirring. After the reaction was completed, water was removed from the slurry to prepare an jade powder coated with a silane compound.
제조예 2: 옥 효소 소금의 제조Preparation Example 2 Preparation of Jade Enzyme Salt
신안군에서 생산한 천일염 10 kg을 원통형의 가마솥에서 1.5 시간 동안 구웠다. 구워진 소금을 상온이 될 때까지 냉각시켰다. 상기 냉각된 천일염을 원통형 믹스 챔버에 넣고 농업회사법인 ㈜화순도곡청정골효소에서 제조한 산야초효소 "백야" 500 ml를 분무하고 건조시켰다. 다음에 pH 7.5~8.5의 천연 알칼리환원수로서 대일광업㈜ 제조"옥산가"500 ml를 분무하고 건조시켰다. 상기 건조된 천일염을 직사광선이 없는 곳에서 3개월 간 숙성시키고, 분쇄하여 옥 효소 소금을 제조하였다. Ten kilograms of sea salt produced by Sinan-gun were baked in a cylindrical cauldron for 1.5 hours. The baked salt was cooled down to room temperature. The cooled sun salt was put in a cylindrical mix chamber and sprayed and dried with 500 ml of Sanyachoenzyme " white night " Next, 500 ml of "Oxane number" manufactured by Daeil Mining Co., Ltd. was sprayed and dried as a natural alkaline reduced water having a pH of 7.5 to 8.5. The dried sun salt was aged for 3 months in a place without direct sunlight and ground to prepare jade enzyme salt.
실시예 1: 치약 조성물의 제조Example 1 Preparation of Toothpaste Composition
다음 표 1에 나타낸 바와 같이 본 발명에 따른 실시예 1 내지 2의 치약 조성물 및 비교예 1의 치약 조성물을 다음의 방법으로 제조하였다. As shown in Table 1, the toothpaste composition of Examples 1 to 2 and the toothpaste composition of Comparative Example 1 according to the present invention were prepared by the following method.
습윤제에 결합제를 첨가하여, pH 8.2의 옥광산 지역에서 생산된 지하수인 알칼리 환원수로 묽게 희석한 후 혼합기를 이용하여 1차 혼합하고, 여기에 연마제, 약효성분, 감미제 및 향료를 넣고 30분간 2차 혼합하고, 여기에 계면활성제를 넣고 혼합하여 치약 조성물을 제조하였다.The binder was added to the humectant, diluted with alkaline reduced water, which is ground water produced in the jade mine area at pH 8.2, and mixed firstly using a mixer, followed by the addition of an abrasive, an active ingredient, a sweetener, and a flavoring agent for 30 minutes. After mixing, the surfactant was added thereto and mixed to prepare a toothpaste composition.
실시예 1Example 1 실시예 2Example 2 비교예 1Comparative Example 1 비교예 2Comparative Example 2
표면이 코팅된 옥분말(제조예 1 제조)Surface-coated jade powder (Preparation 1) 1515 1515 -- 15(비코팅 옥분말)15 (uncoated jade powder)
이산화규소Silicon dioxide 1010 1010 2525 1010
솔비톨 수용액(70%)Sorbitol aqueous solution (70%) 1515 1515 1515 1515
글리세린glycerin 1010 1010 1010 1010
잔탄검Xanthan Gum 1One 1One 1One 1One
카르복시메틸셀룰로오스나트륨Carboxymethyl Cellulose Sodium 1One 1One 1One 1One
N-라우로일글루타민산나트륨Sodium N-lauroyl glutamate 22 22 22 22
스데비오사이드Stevioside 1One 1One 1One 1One
페파민트유Peppermint oil 1.51.5 1One 1.51.5 1.51.5
알란토인클로로히드록시알루미늄Allantoinchlorohydroxyaluminum 22 22 22 22
아미노카프로산Aminocaproic acid 1.51.5 1.51.5 1.51.5 1.51.5
자일리톨Xylitol 1.51.5 1.51.5 1.51.5 1.51.5
어성초추출물Eoseongcho Extract 22 1.51.5 22 22
고삼추출물Red ginseng extract 1.51.5 1.51.5 1.51.5 1.51.5
자몽종자추출물Grapefruit Seed Extract 1.51.5 1One 1.51.5 1.51.5
녹차추출물Green Tea Extract 22 22 22 22
몰약Myrrh 1.51.5 1.51.5 1.51.5 1.51.5
제조예 2의 옥 효소 소금Jade enzyme salt of Preparation Example 2 22 22 2(단순죽염)2 (simple bamboo salt) 22
알로에베라겔Aloe vera gel 22 1.51.5 22 22
메스틱Mastic 22 22 22 22
pH 8.2 알칼리환원수(대일광업㈜ 제조 "옥산가" 사용)pH 8.2 Alkali-reduced water (using "Oxane number" manufactured by Daeil Mining Co., Ltd.) 잔량Remaining amount 잔량Remaining amount -- 잔량Remaining amount
정제수Purified water -- -- 잔량Remaining amount --
㈜ 단위: 중량%Unit: Weight%
시험예 1: 치약 조성물의 성능 평가Test Example 1: Performance Evaluation of Toothpaste Composition
연옥분말, 옥 효소 소금 및 옥광산 주변 채취 pH 8.2 알칼리환원수를 포함하는 실시예 1의 치약 조성물과, 연옥분말 대신 이산화규소를 포함하며, 옥 효소 소금 대신 죽염을 포함하며, 옥광산 주변 채취 pH 8.2 알칼리환원수 대신 정제수를 포함한 비교예 1의 치약 조성물을 각 조성물 당 치주염(5명), 치통(5명), 구취(5명), 의 증상을 호소하는 성인남녀 15명, 총 30명에게 하루 3번씩 30일간 계속 사용하게 하는 블라인드 테스르를 실시하였다. 피험자들이 하기 기준에 의해 점수를 부여하게 하고 그 점수를 평균하여 상기 증상의 개선 정도를 평가하고 그 결과를 하기 표 2에 나타내었다.Purifying jade powder, jade enzyme salt and surrounding jade mineral acid pH 8.2 Toothpaste composition of Example 1 containing alkaline reduced water, and silicon dioxide instead of jade powder, containing bamboo salt instead of jade enzyme salt, around pH 8.2 The toothpaste composition of Comparative Example 1 containing purified water instead of alkaline reduced water was used for 15 adult men and women who complained of the symptoms of periodontitis (5), toothache (5), bad breath (5), and 3 per day. Blind test was performed to keep using 30 times each time. Subjects were given scores according to the following criteria and the scores were averaged to assess the degree of improvement of the symptoms and the results are shown in Table 2 below.
<평가기준><Evaluation Criteria>
현저한 개선효과가 있음: 5 점Significant improvement: 5 points
어느 정도 개선효과가 있음: 3 점Some improvement: 3 points
개선효과 없음: 1점No improvement: 1 point
<미감><Aesthetic>
○: 우수함○: excellent
△: 보통임△: normal
×: 좋지 않음×: not good
실시예 1Example 1 비교예 1Comparative Example 1
치통toothache 4.14.1 3.23.2
치주염Periodontitis 4.34.3 3.03.0
구취Bad breath 4.04.0 3.23.2
미감Taste ○○ △△
상기 표 2에 나타난 바와 같이, 연옥분말, 옥 효소 소금 및 옥광산 주변 채취 pH 8.2 알칼리환원수를 포함하는 본 발명의 실시예 1의 치약 조성물은 치통, 치주염 및 구취에 대하여 매우 우수한 개선 효과를 나타내었다. 반면, 이산화규소, 죽염 및 정제수를 포함한 비교예 1의 치약 조성물은 어느 정도 효과가 확인되었으나, 실시예 1보다 명백히 부족한 효과를 나타내었다. As shown in Table 2, the dentifrice composition of Example 1 of the present invention containing jade powder, jade enzyme salt, and pH 8.2 alkaline reduced water collected around the jade mine showed a very good improvement effect against toothache, periodontitis and bad breath. . On the other hand, the toothpaste composition of Comparative Example 1 including silicon dioxide, bamboo salt and purified water was confirmed to some extent, but showed a clearly insufficient effect than Example 1.
또한, 미감의 경우도, 본 발명의 실시예 1의 치약 조성물은 비교예 1의 치약 조성물보다 우수한 것으로 확인되었다.In addition, also in the case of aesthetics, it was confirmed that the toothpaste composition of Example 1 of the present invention is superior to the toothpaste composition of Comparative Example 1.
시험예 2: 치약 조성물의 안정성 비교 평가Test Example 2: Comparative evaluation of the stability of the toothpaste composition
실시예 1의 치약 조성물을 상온에서 보관하면서 1, 2, 4, 8개월 후에 보관중인 치약 조성물의 성상을 관찰하여 다음의 기준으로 경시 안정성을 평가하였으며, 그 결과를 다음 표 3에 나타내었다.The toothpaste composition of Example 1 was stored at room temperature, and after 1, 2, 4, and 8 months, the properties of the stored toothpaste composition were observed to evaluate the stability over time based on the following criteria, and the results are shown in Table 3 below.
<평가기준><Evaluation Criteria>
○: 상 분리 현상이 없고 연옥 침전 없음○: no phase separation and purgatory precipitation
△: 상 분리 현상이 없고 연옥 침전 발생함△: no phase separation and purgatory precipitation
×: 상 분리가 심하고 연옥 침전 발생함×: Phase separation is severe and purgatory precipitation occurs
실시예 1Example 1 비교예 2Comparative Example 2
보관 1개월1 month storage ○○ ○○
보관 2개월2 months storage ○○ △△
보관 4개월4 months storage ○○ △△
보관 8개월8 months storage ○○ △△
상기 표 3에 나타난 바와 같이, 화학식 1로 표시되는 실란화합물로 표면이 코팅된 연옥분말을 사용한 실시예 1의 치약 조성물은 상 분리 및 연옥가루의 침전이 관찰되지 아니하여 치약 조성물의 안정성이 우수한 것으로 확인되었다.반면, 코팅되지 않은 연옥분말을 사용한 비교예 2의 조성물은 연옥이 바닥에 침전되는 현상이 2개월 지난 후부터 발견되었다.As shown in Table 3, the dentifrice composition of Example 1 using the jade powder coated with the silane compound represented by the formula (1) is excellent in the stability of the dentifrice composition because no separation of the phase separation and purifying jade powder On the other hand, the composition of Comparative Example 2 using the uncoated jade powder was found after two months of phenomena in which the jade was deposited on the bottom.
상기 시험결과는 본 발명의 치약 조성물에 포함된 화학식 1로 표시되는 실란화합물이 연옥분말이 안정적으로 잘 분산되게 하여 연옥분말이 침전되는 것을 방지하는 기능을 수행하는 것을 나타낸다.The test results indicate that the silane compound represented by Formula 1 included in the dentifrice composition of the present invention performs a function of stably dispersing the nephrite powder, thereby preventing the nephrite powder from being precipitated.

Claims (7)

  1. 연마제 20~40 중량%; 솔비톨 수용액 및 글리세린을 포함하는 습윤제 20~40 중량%; 잔탄검 및 카르복시메틸셀룰로오스나트륨을 포함하는 결합제 1~10 중량%; N-라우로일글루타민산나트륨을 포함하는 계면활성제 0.1~5 중량%; 스데비오사이드를 포함하는 감미제 0.1~2 중량%; 페파민트유를 포함하는 향료 0.01~2 중량%; 알란토인클로로히드록시알루미늄, 아미노카프로산, 자일리톨, 어성초추출물, 고삼추출물, 자몽종자추출물, 녹차추출물, 몰약, 옥 효소 소금, 알로에베라겔, 및 메스틱을 포함하는 약효성분 10~25 중량%; 및 잔량의 pH 7.5~8.5의 천연 알칼리환원수;를 포함하는 치약 조성물. Abrasive 20-40% by weight; 20 to 40% by weight of a humectant, including an aqueous sorbitol solution and glycerin; 1 to 10% by weight of a binder including xanthan gum and carboxymethylcellulose sodium; 0.1-5% by weight of a surfactant comprising sodium N-lauroyl glutamate; 0.1 to 2 wt% sweetener including stevioside; 0.01-2% by weight of fragrance containing peppermint oil; 10 to 25% by weight of an active ingredient comprising allantoinchlorohydroxyaluminum, aminocaproic acid, xylitol, fish herb extract, red ginseng extract, grapefruit seed extract, green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic; Toothpaste composition comprising a; and a residual amount of alkaline alkaline water of pH 7.5 ~ 8.5.
  2. 제1항에 있어서,The method of claim 1,
    상기 pH 7.5~8.5의 천연 알칼리환원수는 옥광산 지역에서 생산되는 지하수인 것을 특징으로 하는 치약 조성물. The natural alkaline reduced water of pH 7.5 ~ 8.5 is a toothpaste composition, characterized in that the groundwater produced in the jade mine area.
  3. 제2항에 있어서,The method of claim 2,
    상기 연마제는 연마제 총 중량에 대하여 20~70 중량%의 옥분말과 이산화규소 30~80 중량%를 포함하는 것을 특징으로 하는 치약 조성물.Toothpaste composition characterized in that the abrasive comprises 20 to 70% by weight of jade powder and 30 to 80% by weight of silicon dioxide based on the total weight of the abrasive.
  4. 제3항에 있어서,The method of claim 3,
    상기 옥분말은 평균입자크기가 100 ∼∼ 400 메쉬이며, The jade powder has an average particle size of 100 to 400 mesh,
    하기 화학식 1의 실란화합물로 표면이 코팅처리된 것인 것을 특징으로 하는 치약 조성물:Toothpaste composition characterized in that the surface is coated with a silane compound of the formula (1):
    [화학식 1][Formula 1]
    Figure PCTKR2018002021-appb-I000003
    Figure PCTKR2018002021-appb-I000003
  5. 제3항에 있어서,The method of claim 3,
    상기 실란화합물에 의한 코팅처리는 Coating treatment by the silane compound
    옥분말을 물에 넣고 교반하여 슬러리 형태로 제조하고, 상기 슬러리에 실란화합물을 첨가하고 교반한 후, 물을 제거하는 방법에 의하여 수행되는 것을 특징으로 하는 치약 조성물.Toothpaste composition characterized in that the jade powder is put into water and stirred to prepare a slurry form, the silane compound is added to the slurry and stirred, followed by removing the water.
  6. 제1항에 있어서,The method of claim 1,
    산화티탄을 포함하는 증백제 0.1~3 중량%를 더 포함하는 것을 특징으로 하는 치약 조성물. Toothpaste composition, characterized in that it further comprises 0.1 to 3% by weight of a brightener containing titanium oxide.
  7. 제1항에 있어서,The method of claim 1,
    불화나트륨, 제1불화인산나트륨, 불화주석, 및 아민플루오라이드로 이루어지는 군으로부터 선택되는 1 종 이상의 불소성분을 500 내지 1,500 ppm의 농도로 더 포함하는 것을 특징으로 하는 치약 조성물.A dentifrice composition further comprising at least one fluorine component selected from the group consisting of sodium fluoride, sodium monofluorophosphate, tin fluoride, and amine fluoride at a concentration of 500 to 1,500 ppm.
PCT/KR2018/002021 2017-02-20 2018-02-19 Toothpaste composition comprising jade component WO2018151567A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0022552 2017-02-20
KR1020170022552A KR101854418B1 (en) 2017-02-20 2017-02-20 Toothpaste composition comprising jade ingredient

Publications (1)

Publication Number Publication Date
WO2018151567A1 true WO2018151567A1 (en) 2018-08-23

Family

ID=62244670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/002021 WO2018151567A1 (en) 2017-02-20 2018-02-19 Toothpaste composition comprising jade component

Country Status (2)

Country Link
KR (1) KR101854418B1 (en)
WO (1) WO2018151567A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585101A (en) * 2019-10-23 2019-12-20 徐孝先 Health-care toothpaste for children
CN114681341A (en) * 2022-03-12 2022-07-01 陈健斌 Stable toothpaste capable of removing stains, whitening and relieving gingival inflammation and preparation method thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102299387B1 (en) 2019-07-16 2021-09-07 (주)한일제약 Antimicrobial toothpaste composition
KR102137733B1 (en) 2020-01-22 2020-07-24 김충국 Toothpaste composition comprising shungite
KR102267003B1 (en) 2021-03-31 2021-06-18 이조원 Toothpaste composition containing melanterite
KR102642748B1 (en) * 2021-11-24 2024-03-04 최미경 Shampoo composition for improving scalp and hair health

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100326847B1 (en) * 1999-03-11 2002-03-13 김준한 ToothPaste Which Contains Nephrite Jade Powder And Process For Preparing Thereof
KR20040053647A (en) * 2002-12-17 2004-06-24 한국콜마 주식회사 Toothpaste composition for improving oral sanitation
KR20110065873A (en) * 2009-12-10 2011-06-16 정대준 Concentration liquid for cosmetics containing natural minerals and manufacturing method thereof
KR101121755B1 (en) * 2009-05-15 2012-03-23 황철수 Composition of Toothpaste for Whitening and Method of Preparing thereof
KR101357968B1 (en) * 2011-02-07 2014-02-04 손을택 Bitter Buckwheat Toothpaste Composition
JP2015196642A (en) * 2014-03-31 2015-11-09 ライオン株式会社 Dentifrice composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100326847B1 (en) * 1999-03-11 2002-03-13 김준한 ToothPaste Which Contains Nephrite Jade Powder And Process For Preparing Thereof
KR20040053647A (en) * 2002-12-17 2004-06-24 한국콜마 주식회사 Toothpaste composition for improving oral sanitation
KR101121755B1 (en) * 2009-05-15 2012-03-23 황철수 Composition of Toothpaste for Whitening and Method of Preparing thereof
KR20110065873A (en) * 2009-12-10 2011-06-16 정대준 Concentration liquid for cosmetics containing natural minerals and manufacturing method thereof
KR101357968B1 (en) * 2011-02-07 2014-02-04 손을택 Bitter Buckwheat Toothpaste Composition
JP2015196642A (en) * 2014-03-31 2015-11-09 ライオン株式会社 Dentifrice composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585101A (en) * 2019-10-23 2019-12-20 徐孝先 Health-care toothpaste for children
CN114681341A (en) * 2022-03-12 2022-07-01 陈健斌 Stable toothpaste capable of removing stains, whitening and relieving gingival inflammation and preparation method thereof

Also Published As

Publication number Publication date
KR101854418B1 (en) 2018-05-03

Similar Documents

Publication Publication Date Title
WO2018151567A1 (en) Toothpaste composition comprising jade component
US6503483B2 (en) Dental formulation
KR101955468B1 (en) Preparing method for toothpaste composition comprising natural extracts
US20090269288A1 (en) Black pearl toothpaste
CN107485575A (en) A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof
WO2020054996A1 (en) Foamable mouthwash solid formulation and preparation method therefor
WO2002076433A1 (en) Dental formulation
WO2016010284A1 (en) Toothpaste composition containing curcuma longa l., and preparation method therefor
KR20180081032A (en) Composition for prevention or treatment of oral disease comprising Pueraria Extract
WO2017086653A1 (en) Oral composition and method for preparing same
CN103599182A (en) Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof
KR20170103476A (en) Composition for prevention or treatment of oral disease comprising ROSAE LAEVIGATAE Extract
CN108125815A (en) A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof
KR101881636B1 (en) Composition for prevention or treatment of oral disease comprising Pueraria Extract
CN109846794B (en) Composition, microsphere containing composition and preparation method of microsphere
CN112137928A (en) Multi-effect toothpaste and preparation method thereof
KR20170051006A (en) Oral composition containing both isopropylmethylphenol and oral tissue astringent
CN110200824A (en) A kind of sugar-free toothpaste and its production method containing resveratrol
KR20160061852A (en) Oral composition containing both metal chelating agent and isopropylmethylphenol
KR20200099801A (en) A toothpaste composition with improved antibacterial performance and a toothpaste comprising the composition
KR102502242B1 (en) Toothpaste Composition for Cavum Oris Care and Toothpaste Containing Yellow Ocher
KR101344803B1 (en) Oral care composition comprising extract of machilus thunbergii and sequestering agent
KR20170103494A (en) Composition for prevention or treatment of oral disease comprising Melonis Pedicellus Extract
KR20170103482A (en) Composition for prevention or treatment of oral disease comprising Glechoma hederacea extract
KR101818211B1 (en) Composition for prevention or treatment of oral disease comprising Arctill fructus Extract

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18753741

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18753741

Country of ref document: EP

Kind code of ref document: A1