CN107485575A - A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof - Google Patents
A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof Download PDFInfo
- Publication number
- CN107485575A CN107485575A CN201710762697.XA CN201710762697A CN107485575A CN 107485575 A CN107485575 A CN 107485575A CN 201710762697 A CN201710762697 A CN 201710762697A CN 107485575 A CN107485575 A CN 107485575A
- Authority
- CN
- China
- Prior art keywords
- toothpaste
- bismuth
- glycyrrhetate
- agent
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Abstract
The invention provides a kind of oral cavity helicobacter pylori resistant and the toothpaste of anti-caries stomach strengthening function, the bismuth glycyrrhetate that concentration is 0.001% weight to 10% weight is included in the toothpaste.Bismuth glycyrrhetate combines the gastric mucosal protection function of the anti-inflammatory of glycyrrhizic acid, analgesic, antiulcer, antioxidation and bismuth agent, has multiple antiulcer pharmacology, by improving Ulcer cicatrization quality comprehensively, realizes and cures ulcer, suppresses the effect of recurrence.The bismuth glycyrrhetate toothpaste of the present invention is a kind of common oral amenities, it is practical and convenient, one product multiple-effect, HP and cariogenic bacteria can effectively be killed, bismuth glycyrrhetate is bacterial plaque suppression and cleaning agent simultaneously, so as to be advantageous to suppress and remove bacterial plaque, the chance of bacterial adhesion and aggregation is reduced, reaches and treats both principal and secondary aspect of disease；Be made into external application toothpaste allow one to it is effective, conveniently, enduringly kill oral cavity in helicobacter pylori, so as to reach effectively prevention alimentary infection and prevent gastritis, gastric and duodenal ulcer recurrence purpose.
Description
Technical field
The present invention relates to oral health care product field, in particular to a kind of oral cavity helicobacter pylori resistant and anti-caries
Toothpaste of stomach strengthening function and preparation method thereof.
Background technology
The antrum rete malpighii and epithelium of nineteen eighty-three Australia scholar Warren and Marshall from Patients with Chronic Gastritis are thin
Helicobacter pylori (HP), teeth of the Australian scholar Krajden in 1989 from Gastritis Buccodental are isolated in born of the same parents first
HP is detected in bacterial plaque, and confirms that it is identical with HP in stomach from molecular level.WHO in 1994 is classified as HP infection the infection newly regarded
Disease, domestic and foreign literature report HP is a kind of infectious disease orally propagated.Oral cavity HP is the important letter person warehousing of stomach HP infection.Through stream
Row disease investigates our less than 12 years old teenager's HP infection rate and is up to 40%, and adult's HP infection rates are up to more than 60%, and carious tooth is by WHO
It is classified as and tumour, the big disease for endangering mankind's most serious of angiocardiopathy arranged side by side three, the 12 years old following teenager's caries incidence height in China
Up to 80%.
Helicobacter pylori is Gram-negative, microaerophilic bacterium, survives in oral cavity, stomach and duodenal each region
It is interior.Helicobacter pylori can cause children and adults' stomach cancer, peptic ulcer, gastritis, also with recurrent oral ulceration, periodontitis,
Hypoferric anemia, ITP, growth retardation etc. are closely related.HP and cariogenic bacteria belong to together micro- aerobic
Bacterium, the two complement each other bacterium collection adhesion on the plaque, the two have infection generality and disguise, the family of morbidity and
Aggregation, there is high infection rate in the whole world and China.As gastral entrance, the presence influence of helicobacter pylori is deep and remote in oral cavity
The effect of Helicobacter pylori eradication therapy, particularly late result.Helicobacter pylori in oral cavity is stored in bacterial plaque, oral cavity sticks
Film, calculus dentalis, gingival pocket, saliva, lesion dental pulp in.Bacterial plaque has unique " biomembrane " structure, and dental pulp is in relative envelope
In the lacuna closed, helicobacter pylori can escape the killing of antibiotic, thus systemic administration it is acted on it is little.Over time
Passage, also more and more higher, eradication rate are just more and more lower for resistant rate of the helicobacter pylori to common antibiotics.Therefore control its mouth-
Oral instructions are broadcast to propagate with mouth-stomach and are even more important.Pay attention to oral hygiene, prevent that illness finds its way in by the mouth, increasingly become prevention helicobacter pylori
The important measures of infection, prevention stomach trouble and stomach cancer.Periodontal scaling is periodically done, removes bacterial plaque and dental calculus, eliminates oral pocket；Prevention and
Carious tooth, dental pulp and periodontal disease are treated, pays attention to artificial tooth sanitation and hygiene, it is very necessary to remove helicobacter pylori and hide with staying.It is existing
There is technology using heavy dose of Multiple Classes of Antibiotics while take killing helicobacter pylori, add the resistance to the action of a drug of helicobacter pylori, easily
Cause disease recurrent exerbation, add treatment difficulty.The shortcomings that prior art is：Taking heavy dose of antibiotic makes helicobacter pylori
Develop immunity to drugs.Antibiotic is effective means of the mankind to bacterial-infection resisting, and bacterium, which produces drug resistance, makes effective antibiosis originally
The therapeutic effect of element is reduced or lost, and adds the treatment difficulty and medical treatment cost of patient disease.
Toothpaste is the oral health care articles for use that must all use for each person every day, the existing toothpaste with sterilizing function, is had
Addition antibiotic, disinfectant, such as triclosan, chlorohexidene, by harmful bacteria, beneficial bacterium all kill, destroy the micro- life in oral cavity
State environment, add the resistance to the action of a drug of bacterium.Therefore a kind of harmful bacteria growing of effectively suppression is invented, improves Oral health behaviours, promote
The reparation and defence of oral mucosa, have and kill helicobacter pylori and prevention, treatment dental caries function, easy to use, treatment cost
Low, the extensive anti-oral helicobacter pylori Chinese medicinal toothpaste of popularization, is very significant.
The content of the invention
It is an object of the invention to provide a kind of helicobacter pylori that can be killed in oral cavity, and can is killed cariogenic in oral cavity
Bacterium, there is preventing and treating stomach cancer, gastric ulcer, enterelcosis and the preventing decayed tooth that cleans the teeth, the anti-oral helicobacter pylori of oral cavity antiallergic deodouring effect
Toothpaste and preparation method thereof.
To achieve the above object, the present invention provides following technical scheme：
A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function, it is characterised in that：The toothpaste includes
Toothpaste base-material and active ingredient bismuth glycyrrhetate, the radix glycyrrhizae that concentration is 0.001% weight to 10% weight is included in the toothpaste
Sour bismuth.
Preferably, the bismuth glycyrrhetate that concentration is 0.01% weight to 5% weight is included in the toothpaste；Preferably, institute
State the bismuth glycyrrhetate comprising concentration for 0.5% weight to 3% weight in toothpaste.Further, the bismuth glycyrrhetate is by sweet
Careless cream solution and bismuth nitrate solution precipitation gained, this product contain bismuth glycyrrhetate, by dry product with bismuth (Bi) calculating, it should be 11.0%~
15.0%.
Preferably, the toothpaste base-material include NMF, thickener, rubbing agent, foaming agent, essence, preservative and its
Its additive；The thickener be sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer, xanthans, hydroxypropyl melon glue,
One or more of mixing of carragheen；The NMF is the one or more in sorbierite, glycerine, propane diols or polyethylene glycol
Mixing；The rubbing agent is titanium dioxide, calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, titanium dioxide
One or more of mixing in silicon, aluminium hydroxide, hibbsite, calcite in powder, leuchtenbergite；The foaming agent is ten
Sodium dialkyl sulfate, Cocoamidopropyl betaine or dodecanoyl sodium sarcosinate；The preservative is triclosan, Metagin
One or more of mixing in ester, ethylparaben, sodium benzoate；The essence be peppermint oil, lemon sesame oil, spearmint oil,
Orange oil, mandarin oil, wintergreen, caryophyllus oil, cinnamon oil, fennel oil, menthol, borneol, citral, lauryl aldehyde, vanillic aldehyde, acetic acid
One or more of mixing in pentyl ester；Other additives are colouring agent, antioxidant, pH adjusting agent, taste-modifier, work(
Imitate one or more of mixing of additive.
Further, the taste-modifier is xylitol, saccharin sodium, Aspartame, Sucralose, the one of sodium chloride
Kind or several mixing；The colouring agent is chlorophyll, titanium dioxide, allured red pigment, bright blue pigment, lemon yellow pigment, pearl essence
At least one of；；The pH adjusting agent is sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium acid carbonate, silicon
One or more of mixing of sour sodium；The antioxidant is butylated hydroxy anisole (BHA), dibutyl hydroxy toluene (BHT), chlorine
Change one or more of mixing of stannous, phytic acid, vitamin C, vitamin E；The functional additive is caries preventive agent, desensitizer, resisted
The agent of bacterium anti-inflammation hemostasia, one or more of mixing except stain brightening agent, calculus dentalis inhibitor, flavorants.
Preferably, in toothpaste prescription each component percentage by weight be 0.001%~10% bismuth glycyrrhetate, 10%~
30% NMF, 1%~3% thickener, 40%~50% rubbing agent, 1%~3% foaming agent, 0.5%~1.5%
Spices, 0.1%~0.5% preservative, other additives 0%~5%, surplus are water.Preferably, it is each in the toothpaste prescription
The bismuth glycyrrhetate, 35%~65% NMF, 0.2%~1% thickening that the percentage by weight of component is 0.001%~10%
It is agent, 10%~25% rubbing agent, 1%~2% foaming agent, 0.5%~2% essence, 0.1%~0.5% preservative, other
Additive 0%~5%, surplus are water.Further, the preparation method of described toothpaste, it is characterised in that including following step
Suddenly：
1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieves；
2) by above-mentioned bismuth glycyrrhetate powder, NMF and preservative mix and be put into deionized water made of stirring go from
The sub- aqueous solution, thickener, rubbing agent, foaming agent, the mixing of other additives are then added, is sent into three-in-one vacuum Manufacturing medicine extract machine, it is high
Speed stirring is milled 25~40 minutes, vacuum outgas, is then added essence and is stirred for mixing in 10~25 minutes of milling, obtains toothpaste cream
Body, pass through sterile filling, packaging.
Preferably, in the toothpaste prescription each component percentage by weight be 0.001%~10% bismuth glycyrrhetate, 50%
~80% NMF, 0.5%~1% thickener, 10%~30% rubbing agent, 1%~2% foaming agent, 0.5%~
1.5% essence, 0.1%~0.5% preservative, other additives 0%~5%, water 0%；The thickener is carbomer；
The NMF is polyethylene glycol, glycerine, the mixed liquor of propane diols.Further, the preparation method of described toothpaste, it is special
Sign is to comprise the following steps：
1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieves；
2) carbomer Carbopol is distributed in polyethylene glycol；Glycerine, propane diols NMF are added into carbomer
In Carbopol- polyethylene glycol 400 solution, moderate-speed mixer 5-10 minutes, liquid material is made；Then by above-mentioned bismuth glycyrrhetate powder,
Thickener, rubbing agent, foaming agent, the mixing of other additives, are sent into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred is milled 25~40 points
Clock, vacuum outgas, then add essence and be stirred for mixing in 10~25 minutes of milling, obtain lotion of toothpaste, pass through sterile filling, bag
Dress.
Compared with prior art, the beneficial effects of the invention are as follows：
1) glycyrrhizic acid has anti-inflammatory, antiulcer, antiviral, enhancing immunologic function, antiallergy, antibiooxidation, resistance state
Reaction lamp pharmacological activity.Bismuth agent is clinical conventional gastric mucosa protective agent and medicine for anti Helicobacter pylori, can stimulate mucus
Secretion increase gastric mucosal barrier effect.Bismuth glycyrrhetate combines anti-inflammatory, analgesic, antiulcer, antioxidation and the bismuth of glycyrrhizic acid
The gastric mucosal protection function of agent, there is multiple antiulcer pharmacology, by improving Ulcer cicatrization quality comprehensively, realize cure ulcer,
The effect of suppressing recurrence.The present invention wore into bismuth glycyrrhetate using colloid mill the superfine powder of 200 mesh sieves, added medicine
Specific surface area, make it have larger contact surface with helicobacter pylori in the oral cavity, add the sterilizing ability of medicine, so as to
Reduce the dosage of medicine.Formulation of tooth-paste of the present invention is reasonable, and technique is simple, and lotion is uniform and stable, is easy to industrialization；It is made into
External application toothpaste, allow one to it is effective, conveniently, enduringly kill oral cavity in helicobacter pylori, so as to reach effective prevention
Alimentary infection and prevention gastritis, the purpose of the recurrence of gastric and duodenal ulcer.
2) bismuth glycyrrhetate toothpaste of the invention is a kind of common oral amenities, and practical and convenient, a product multiple-effect can be effective
Killing HP and cariogenic bacteria, while bismuth glycyrrhetate be bacterial plaque suppress and cleaning agent, so as to be advantageous to suppress and remove bacterial plaque,
The chance of bacterial adhesion and aggregation is reduced, reaches and treats both principal and secondary aspect of disease, improves prevention effect.Clinical test shows that 500 are burst with stomach
For the patient of ulcer with this product after continuous one month brush teeth, 1 year Follow-up observation, oral cavity HP negative conversion rate reaches more than 92%.
Each component in toothpaste can use but be not limited to following component：
1st, rubbing agent
Abrasive is can to wipe the soft dirt of dental surface with toothbrush collective effect in toothpaste, mitigates tooth stain, bacterial plaque, tooth
The solid material composition of the foreign substances such as calculus.Abrasive is one of main component of toothpaste, powdery generally not soluble in water
Solid, particle and quality are moderate, do not damage enamel and dentine.There can be natural magnesium as the conventional raw material of toothpaste abrasive
Calcium, dicalcium phosphate dihydrate (dicalcium phosphate dihydrate), hydrated silica (silica), precipitated calcium carbonate, aluminium hydroxide, phosphoric acid
Hydrogen calcium (calcium phosphate dibasic anhydrous) etc..The rubbing agent commonly used in toothpaste has：
1) calcium carbonate (CaCO3)：Calcium carbonate has two kinds of a heavy and lightweight, powdered whiting be by the limestone in rock and
Calcite crushes, grinding, refined forms.Precipitated calcium carbonate is that calcium salt is dissolved in hydrochloric acid, then is passed through carbon dioxide, obtains carbonic acid
Calcium precipitate.Precipitated calcium carbonate particle is thin, light specific gravity, available for toothpaste.
2) calcium monohydrogen phosphate (the water salt CaHPO of calcium monohydrogen phosphate two4·2H2O and calcium monohydrogen phosphate anhydrous salt CaHPO4)：Calcium monohydrogen phosphate
It is divided into two kinds of the two water salt and anhydrous salt of two molecular waters.Two water salt and other compositions have good Combination, but due to anhydrous salt
Hardness is high, and frictional force is strong, therefore special except in the toothpaste of smoke puff, 5%~10% anhydrous salt can be mixed into two water salt.
3) calcium pyrophosphate (Ca2P2O7)：Calcium pyrophosphate is by obtained from calcium monohydrogen phosphate high-temperature process.Got along well and contained due to it
Fluorine compounds react, therefore can be used as the base-material of toothpaste with fluoride.
4) silicate hydrate (SiO2·nH2O)：Silicate hydrate is very thin white particles, available in transparent toothpaste.Separately
Outside, because its specific volume is big, the extender and tackifier that can make toothpaste use.
5) aluminium hydroxide (A1 (OH)3)：The particle of aluminium hydroxide is thicker, but not damages enamel, and can increase toothpaste
Brightness, and there is the excellent power that cleans the teeth.
2nd, NMF
NMF is that have keep lotion moisture, safeguard lotion mobility, reduce lotion freezing point in order to life in toothpaste
The liquid charging stock composition that production processing and consumer use.NMF is one of main component of toothpaste, generally polyalcohols thing
Matter, lotion can be made to keep flexibility and mobility, be easy to pipeline and filling processing.Within the toothpaste shelf-life, it can keep
Lotion is moist, is not hardened, and does not influence to extrude from flexible pipe；The congealing point of lotion is reduced, prevents from losing conjunction when after frost melting
Suitable denseness, there is separation of solid and liquid phenomenon.Toothpaste NMF can be used as.There are glycerine, D-sorbite for the wetting agent in toothpaste
Liquid (sorbierite), propane diols, polyethylene glycol etc..
3rd, thickener
Thickener is also known as adhesive, adhesive, is to disperse, swell in toothpaste liquid phase, form stable colloid with the toothpaste that suspends
Solid phase, prevent the material composition that solid phase components separate with liquid phase component in toothpaste.Thickener is one of main component of toothpaste, often
There are 3 classes：Organic synthesis glue, such as cellulose gum (sodium carboxymethylcellulose), hydroxyethyl cellulose, carbomer (carbomer)
Deng；Natural plant, such as xanthans (xanthan gum), hydroxypropyl melon glue, Chondrus crispus (carragheen)；Inorganic glue, such as increase
Thick type hydrated silica (silica), colloidality Magnesiumaluminumsilicate etc..
4th, foaming agent
Foaming agent (surfactant) is that surface tension of liquid can be reduced in toothpaste, has good wetting, foaming, breast
Change, the material composition of detergent action.Foaming agent is one of main component of toothpaste, is that a kind of security is good, excitant is small, foam
Abundant surfactant, tartar, bacterial plaque etc. can be made to be emulsified and suspend, oral cavity is removed by gargling, it is clear so as to reach
The purpose of clean mouth chamber.Can having as toothpaste foaming agent：Laruyl alcohol sodium sulfovinate (lauryl sodium sulfate), Hamposyl L
Sodium (dodecanoyl sodium sarcosinate) etc..Widely used at present is neutral detergent-sodium lauryl sulfonate.Energy fast foaming, both
Can be foamed foam, and can rinse the mouth in dirt.The surfactant purity requirement of toothpaste is very high, it is impossible to has peculiar smell, typically
Dosage is 2%.
5th, preservative
Preservative refers to prevent toothpaste corruption, rotten material composition within the shelf-life.Toothpaste has a variety of organic principles,
Production process is complicated, and the microorganism of may be infected is also diversified, therefore the selection to toothpaste preservative is needed by micro-
Biological challenge experiment could be determined finally.Conventional toothpaste preservative mainly includes：Sodium benzoate, methyl hydroxybenzoate (Metagin
Ester) etc..Toothpaste efficiency composition such as Chlorhexidine, Cetylpyridinium Chloride, triclosan, sodium fluoride, sodium monofluorophosphate etc. also have antiseptic effect.
6th, essence
Toothpaste essence is the fragrance with reference to natural plants, is formed using natural perfume material and synthetic perfume are formulated, is to have
The mixture of natural flavour mountaineous and various odor types.Essence is one of main component of toothpaste, typically by meeting food hygiene requirement
Tens of kinds of perfume materials are made, and assign toothpaste refrigerant, tasty and refreshing and pure and fresh sensation, can cover bad possessed by toothpaste various composition
Smell and taste, the stability of toothpaste is not influenceed.Can have as the raw material of toothpaste essence it is hundreds of, after rational allocation turn into tool
There is the essence of certain feature odor type, such as Mint Essence, spearmint essence, the refreshing essence of Chinese ilex essence, fruit essence, tea, medicine essence
Deng.Toothpaste is mainly peppermint with spices, and it is to confer to a kind of indispensable composition of toothpaste cooling feeling.Pennyroyal is divided into thin again
The many kinds of substance such as lotus alcohol (menthol), peppermint oil, peppermint, and the spices derived from by it.In addition, fruits also can be used
Essence, such as citrus flavors.
7th, taste-modifier
Taste-modifier refer to for cover some compositions of toothpaste poor taste, assign the pleasant taste of toothpaste original
Expect composition.Taste-modifier is presently mainly sweetener and savory agent.Taste-modifier is one of main component of toothpaste, is commonly used
Have xylitol, saccharin sodium, aspartame (Aspartame), tri-chloro galactose type sugared (Sucralose) etc., conventional toothpaste savory agent
There is food grade sodium chloride etc..To improve the mouthfeel of toothpaste, a small amount of saccharin is added in toothpaste.Due to glycerine as wetting agent etc.
With sweet taste, therefore saccharin is generally 0.01%~0.1% with dosage.
8th, antioxidant
Antioxidant is that one kind causes discoloration, spoiled phenomenon because of oxidation for preventing, suppressing or postponing toothpaste, from
And improve the material composition of the stable flight of steps leading to a palace hall of toothpaste.Antioxidant needs to add according to special formulation, is applied in toothpaste
Antioxidant have butylated hydroxy anisole (BHA), dibutyl hydroxy toluene (BHT), stannous chloride, phytic acid, ascorbic acid (dimension
Raw plain C), tocopherol (vitamin E) etc..
9th, colouring agent
Colouring agent refers to be used to change toothpaste outward appearance, creates specific visual experience and the material composition of effect association,
Use if necessary.The kind applied at present includes pigment, the color lake of pigment, colour particles etc..Toothpaste pigment is a lot, greatly
Cause is divided into natural pigment (such as chlorophyll) and chemical synthesis pigment (such as titanium dioxide CI 77891, amaranth cI 16185, lemon yellow
CI 19140, light blue CI 42090 etc.), can be a kind of or a variety of blendings during use.The color lake of pigment is mainly used in
Among striped toothpaste, make toothpaste that there is vivid color, it is desirable to meet relative national standards, do not influence the stability and tool of toothpaste
There is excellent anti-diffusion.Colour particles, which are applied to toothpaste, can produce the outward appearance of novelty and unique mouthfeel, it is desirable to meet state
The relevant standard requirement of family, its hardness must not produce abrasion to dentine.
10th, pH adjusting agent
PH adjusting agent is toothpaste stability contorting pH within the shelf-life, avoids that to produce water outlet, inflatable existing because abrasive dissociates
The material composition of elephant.PH adjusting agent needs to add according to special formulation.Conventional toothpaste acid-base buffer agent has tetrasodium pyrophosphate (burnt
Sodium phosphate), sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium acid carbonate, sodium metasilicate etc..Toothpaste abrasive hydrogen phosphate dihydrate
Calcium, aluminium hydroxide, silica have buffer effect of fuluic acid simultaneously.
11st, functional additive
Functional additive is to aid in the original that effect type toothpaste realizes one or more toothpaste efficiencies in addition to basic function
Expect composition, be the integral component of effect type toothpaste, its basic demand is：It is safe to the human body, there is the mechanism of action of science and pass through
The effect of authoritative institution, is verified.Currently used category includes：Caries preventive agent, desensitizer, anti-inflammation styptic, brighten except stain
Agent, calculus dentalis inhibitor, flavorants etc..
Caries preventive agent refers to make an addition in the dental products such as toothpaste, can help to prevent and treat the effective component of carious tooth, often
Caries preventive agent is xylitol, Yolk immunoglobulin (the IgY factors), hydroxyapatite, calcium glycerophosphate, stannous fluoride, fluorine
Change sodium, sodium monofluorophosphate etc..
Desensitizer mainly plays desensitization from the following aspects：1) physical method closing dentinal tubule outer end (is covered
Lid acts on)；2) chemical substance reacts with dental tissue and forms precipitation, as salt or proteins precipitate block dentine
Tubule (ponding and corrosiveness)；3) Cucumber penetrates into dental pulp through dentinal tubule, blocks or suppresses Intradental nerve quilt
Excite (suppression and blocking effect)；4) secondary dentin is induced to form (inducing action).But the single desensitization mechanism of application is treated
The effect limitation of hypersensitive dentin, at present, it is intended to using the desensitizer of mixed type desensitization mechanism, to reach preferably desensitization effect
Fruit.Desensitizer is generally divided into：1) inductivity desensitizer can induce secondary dentin and be formed.Such as calcium hydroxide desensitizing paste, its
Desensitization principle is to promote to form reparative dentin on the corresponding pulp cavity wall of sensitive part, meanwhile, calcium hydroxide is run into two in air
Carbonoxide generates tosca in dentinal tubule, to reduce the reactivity of tooth, plays a part of dual desensitization, and
Also there is protective effect to the pulp vitality after standby tooth.2) corrosivity desensitizer can form protein precipitation.It is more representational
Effect (Gluma desensitiser), main component are containing the glutaraldehyde and 36% 2- that mass fraction is 5%
Hydroxyethyl meth acrylate.3) main component of blocking property desensitizer blocking property desensitizer is various salts, can form salt
Precipitation.(1) GreenTM:GreenTM is current domestic the most frequently used blocking type desensitizer, wherein A agent phosphoric acid potassium, potassium carbonate, hydroxyl
Benzene methyl and deionized water；B agent chloride containings calcium, strontium chloride, deionized water and sodium benzoate.(2) Oxalates desensitizer:A lot
Research display：The desensitizer of the composition containing oxalic acid is applied to dentin surface, can dissolve the calcium ion of release dentin surface, and
It is in connection to form insoluble calcium oxalate crystal, so as to reach the purpose of closing dentinal tubule.(3) fluoride:Fluorine
The species of compound is more, such as sodium fluoride, ammonium fluoride silver and stannous fluoride.The effect of fluorine be with tissue of tooth formed calcirm-fluoride and
Fluor-apatite, to block dentinal tubule, reduce its permeability.Pass through fluorine containing the sodium fluoride glycerine paste that mass fraction is 75%
Ion is penetrated into dental hard tissue, and the hydroxyl replaced in hydroxyapatite forms fluor-apatite, reduces the straight of dentinal tubule
Footpath, to reach the purpose of desensitization.4) spreadability desensitizer：Spreadability desensitizer is primarily referred to as the material based on resin, can send out
The desensitizer of raw polymerisation.That clinically applies has：Single Bond、All-Bond、Seal-Protect、One-Step
With Prompt L-Pop etc..5) inhibition desensitizer is blocked：Inhibition desensitizer is blocked to suppress nerve conduction.Potassium nitrate takes off
Quick mechanism is that potassium ion can penetrate into nerve endings at nearly dental pulp in dentine, regulation and control sodium, potassium ion from dentinal tubule
Exchange, make nerve ending cell membrane depolarization, so as to suppress the generation of nerve impulse.Potassium nitrate can be made solution, gel and
A variety of formulations such as paste treat hypersensitive dentin.
Such as：1) dioxygen is often added in toothpaste for the bactericide such as the guanidine radicals hexane of phenyl two and cypress alcohol, copper to remove halitosis
Chlorophyllin is to preventing halitosis from also having certain effect.2) preventing and treating carious tooth can add fluorine compounds, can suppress residue in oral cavity and send out
Ferment, again strengthen the enamel of dental surface；Consider from security, Fluoride in Toothpaste content is provided below 1000 micrograms.
In the crowd for drinking fluorine-containing natural water, the incidence of disease of carious tooth is relatively low, but drinks the high water of fluorinated volume, and dental surface can be formed
Gonorrhoea shape (plaque-like tooth), makes dentine become fragile on the contrary.3) bioactivity glass, its active ingredient form hydroxyl after being reacted with saliva
Base phosphorite crystal is deposited on dental surface, closes exposed dentinal tubule, available for treating dental hypersensitiveness.Biology is living
Property glass forms bottom is a kind of biology with excellent bio-compatibility and osteogenic activity being made up of a variety of inorganic ions
Active material.Its Na2O-CaO-SiO2-P2O5System reacts with water and saliva and generates crystalloid hydroxyapatite layer (ore deposit
Change), carbonated hydroxyapatite has high surface area, can adsorb substantial amounts of biomolecule, so as to promote extracellular response.Biology is living
Property glass is by generating crystallinity hydroxyapatite layer so that original inert simple glass, becomes that specific life can be reached
Thing activity, therefore it is referred to as bioactivity glass.By development for many years, bio-vitric is applied to be obtained in oral care implement
Develop rapidly, the appearance of the strong tooth product of NovaMin series is described as the newest revolution of toothpaste industry in the U.S., domestic
Camgna (Gai Meila) strontium-reinforced bioactive glass toothpaste also obtains patent property protection.Bio-vitric is good by its
Good remineralization effect and antibacterial effect, there is good answer in terms of the diseases such as treatment dentine hypersensitivity, dental caries and gingivitis
It is a kind of safe and effective bioactive materials that can safeguard oral health with prospect.
Embodiment
Detailed content and technology on the invention illustrate, are now described further with embodiment, it will be appreciated that
, these embodiments are only to be used to illustrate, and are not necessarily to be construed as the limitation of the invention implementation.Bismuth glycyrrhetate：
It is the primary raw material of the present invention, from pharmaceutical grade, purchased from Lanzhou Heshengtang Pharmaceutical Co., Ltd., this product contains bismuth glycyrrhetate, by dry
Dry product are calculated with bismuth (Bi), should be 11.0%~15.0%.
Embodiment 1：The preparation of friction-type toothpaste
The prescription of the friction-type toothpaste of table 1
Preparation method：
1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieves；
2) by above-mentioned bismuth glycyrrhetate powder, NMF and preservative mix and be put into deionized water made of stirring go from
The sub- aqueous solution, thickener, rubbing agent, foaming agent, the mixing of other additives are then added, is sent into three-in-one vacuum Manufacturing medicine extract machine, it is high
Speed stirring is milled 25~40 minutes, vacuum outgas, is then added essence and is stirred for mixing in 10~25 minutes of milling, obtains toothpaste cream
Body, pass through sterile filling, packaging.
Embodiment 2：The preparation of friction-type toothpaste
The prescription of the friction-type toothpaste of table 2
Preparation method is the same as embodiment 1.
Embodiment 3：The preparation of friction-type toothpaste
The prescription of the friction-type toothpaste of table 3
Preparation method is the same as embodiment 1.
Embodiment 4：The preparation of friction-type toothpaste
The prescription of the friction-type toothpaste of table 4
Preparation method is the same as embodiment 1.
Embodiment 5：The preparation of friction-type toothpaste
The prescription of the friction-type toothpaste of table 5
Preparation method is the same as embodiment 1.
Embodiment 6：The preparation of gel type toothpaste
The prescription of the gel type toothpaste of table 6
Preparation method：
1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieves；
2) by above-mentioned bismuth glycyrrhetate powder, NMF and preservative mix and be put into deionized water made of stirring go from
The sub- aqueous solution, thickener, rubbing agent, foaming agent, the mixing of other additives are then added, is sent into three-in-one vacuum Manufacturing medicine extract machine, it is high
Speed stirring is milled 25~40 minutes, vacuum outgas, is then added essence and is stirred for mixing in 10~25 minutes of milling, obtains toothpaste cream
Body, pass through sterile filling, packaging.
Embodiment 7：The preparation of gel type toothpaste
The prescription of the gel type toothpaste of table 7
Preparation method is the same as embodiment 6.
Embodiment 8：The preparation of gel type toothpaste
The prescription of the gel type toothpaste of table 8
Preparation method is the same as embodiment 6.
Embodiment 9：The preparation of anhydrous type toothpaste
The prescription of the anhydrous type toothpaste of table 9
Preparation technology：
1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieves；
2) Carbopol is distributed in polyethylene glycol；Glycerine, propane diols NMF are added into Carbopol- polyethylene glycol
In 400 solution, moderate-speed mixer 5-10 minutes, liquid material is made；Then by above-mentioned bismuth glycyrrhetate powder, thickener, rubbing agent, foaming
Agent, the mixing of other additives, are sent into three-in-one vacuum Manufacturing medicine extract machine, and high-speed stirred is milled 25~40 minutes, vacuum outgas, is then added
Enter essence and be stirred for mixing in 10~25 minutes of milling, obtain lotion of toothpaste, pass through sterile filling, packaging.
Embodiment 10：The preparation of anhydrous type toothpaste
The prescription of the anhydrous type toothpaste of table 10
Preparation technology is the same as embodiment 9.
Embodiment 11：The preparation of anhydrous type toothpaste
The prescription of the anhydrous type toothpaste of table 11
Preparation technology is the same as embodiment 9.
Reference examples：The preparation of the toothpaste of reference examples is carried out with reference to embodiment 2
The prescription of the reference examples toothpaste of table 12
Preparation method：
1) dipotassium glycyrrhizinate is crushed, crosses 150-200 mesh sieves；
2) above-mentioned dipotassium glycyrrhizinate powder, NMF and preservative are mixed and be put into deionized water made of stirring and gone
Deionized water solutions, thickener, rubbing agent, foaming agent, the mixing of other additives are then added, is sent into three-in-one vacuum Manufacturing medicine extract machine,
High-speed stirred is milled 25~40 minutes, vacuum outgas, is then added essence and is stirred for mixing in 10~25 minutes of milling, obtains toothpaste
Lotion, pass through sterile filling, packaging.
Test example 1：Fungistatic effect is tested
This effect example has investigated toothpaste made of embodiment 1-8 to carious tooth, the inhibition of bacterial plaque, carries out pylorus
Pylori, turn sugar chain coccus (Streptococcusmutans) and micrococcus scarlatinae (Streptococcussobrinus)
Suppress the detection of effect.
As a result show, toothpaste made of embodiment 1-8 is 99.99% to the inhibiting rate of helicobacter pylori, to oral cavity dental caries
Turn streptococcic inhibiting rate of sugar of tooth is 99.99% and the inhibiting rate of micrococcus scarlatinae is 99.99%.Above-mentioned two kinds of bacteriums
A variety of diseases such as bacterial plaque, periodontitis, parulis, sphagitis, tonsillitis can be caused, it is also possible to cause streptococcus pneumonia sense
Dye causes pneumonia and other serious diseases, it is also possible to causes and is infected with malignant tumour (especially alimentary canal) patient bargen's streptococcus
Cause bacteremia, endocarditis, and through organ-tissue antigenic similarity, acute rheumatic fever and acute kidney ball ephritis etc. can be caused
A variety of diseases.Result of the test confirms that toothpaste made of embodiment 3 has good suppression carious tooth, bacterial plaque, periodontitis and gum
The effect of abscess.
Test example 2：Stability test
According to QB 8372-2008 standards, the obtained products of embodiment 1-8 are tested, indices are as follows：
The stability study of the embodiment of the present invention of table 13
As can be seen from the above table, toothpaste of the invention, its every organoleptic indicator, physical and chemical index, sanitary index accord with completely
QB 8372-2008 standards are closed, while the sample of embodiment 1,5,7 is also placed in the environment of -10 DEG C, 48 DEG C and respectively deposited by we
48 hours, recover after taking-up to room temperature, find the uniform foreign of lotion, it is seen that its resistance to jelly, heat resistance are also very good.
Toothpaste made of the present embodiment can still remain round when uniform color and luster and the paste via body extrusion is presented
The lotion of column type strip, even if after 45 minutes carry out centrifugal test with 3500 revs/min of rotating speed, water outlet is not presented for the paste
Phenomenon；And after 45 DEG C of constant temperature 60 days or 5 DEG C of constant temperature caloric test of 60 days, it can all maintain cylindrical type strip lotion, it was demonstrated that
Toothpaste provided by the invention has splendid stability.
Test example 3：Clinical trial
1. general information
Randomly select the Patients with RAU 320 for meeting diagnostic criteria, man 148, female 172；Age 19~64
Year, the recurrence 1 time 67 of aphtha 1 month, recurrence in 2 months 1 time 54, recur within 1 week 1 time 32, the Non-intermittent phase 67；Light-duty recurrence
Property aphtha 161；Heavy RAU (periglandular aphtha) 83, bleb sample aphtha (mouth tip aphtha) 76, is randomly divided into
Treatment group 120, the difference nonsignificance such as each 100 of control group 1 and 2, three groups of patient ages, sex composition ratio, the course of disease.Ginseng
According to《Oral mucosal disease》In diagnostic criteria on canker sore and indexing.
2. treatment method
The conventional vitamin B of control group 12, vitamin C three times/d, and with water melon frost spray in 6 times/d on ulcer surface,
Average 7d is 1 course for the treatment of.
Control group 2 applies affected part in the toothpaste that morbidity takes reference examples of the present invention to prepare on the 2nd day, early, middle and late each 1 time.
Treatment group applies affected part in the toothpaste that morbidity takes the embodiment of the present invention 2 to prepare on the 2nd day, early, middle and late each 1 time.
3. the standard of curative effect evaluation
The tentative mark of the effect of RAU (RAU) passed through for 2001 using Chinese Medical Association's mucous membrane disease special interest group evaluation
Quasi- IN stagings.Effective is total backlash time lengthening, and total ulcer number is reduced；It is effectively total backlash time lengthening, total ulcer number
Mesh does not have significant change or total ulcer number to reduce, and the total backlash time is without significant change；It is invalid when being total ulcer number and total backlash
Between without significant change.Total effective rate=(effective number of cases+effective number of cases)/total number of cases × 100%.
Counted according to Chi-square Test method.
4. result
Two groups of curative effects compare, and have significant difference (P ＜ 0.01) (table 14)
14 two groups of curative effects of table compare
| Group | Recovery from illness/example | Effective/example | Effectively/example | Invalid/example | Total effective rate/% |
| Treatment group | 57 | 41 | 20 | 2 | 98.3 |
| Control group 1 | 11 | 37 | 25 | 27 | 66.3 |
| Control group 2 | 41 | 33 | 16 | 10 | 90.0 |
The above is only the preferred embodiment of the invention, it is impossible to the implementation model of the invention is limited with this
Enclose, i.e., every simple equivalent changes and modifications made according to the invention claim and innovation and creation description,
All still fall within the scope that the invention is covered.
Claims (10)
- A kind of 1. toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function, it is characterised in that：The toothpaste includes tooth Cream base material and active ingredient bismuth glycyrrhetate, the glycyrrhizic acid that concentration is 0.001% weight to 10% weight is included in the toothpaste Bismuth.
- 2. toothpaste according to claim 1, it is characterised in that：In the toothpaste comprising concentration be 0.01% weight extremely The bismuth glycyrrhetate of 5% weight；Preferably, the bismuth glycyrrhetate that concentration is 0.5% weight to 3% weight is included in the toothpaste.
- 3. according to any described toothpaste of claim 1-2, it is characterised in that：The bismuth glycyrrhetate is by licorice root ointment solution and nitric acid Bismuth solution precipitation gained, this product contain bismuth glycyrrhetate, are calculated by dry product with bismuth (Bi), should be 11.0%~15.0%.
- 4. toothpaste according to claim 1, it is characterised in that：The toothpaste base-material includes NMF, thickener, friction Agent, foaming agent, essence, preservative and other additives；The thickener is sodium carboxymethylcellulose, hydroxyethyl cellulose, card One or more of mixing of ripple nurse, xanthans, hydroxypropyl melon glue, carragheen；The NMF is sorbierite, glycerine, the third two One or more of mixing in alcohol or polyethylene glycol；The rubbing agent is titanium dioxide, calcium carbonate, calcium phosphate dibasic dihydrate, nothing One in water calcium monohydrogen phosphate, calcium pyrophosphate, silica, aluminium hydroxide, hibbsite, calcite in powder, leuchtenbergite Kind or several mixing；The foaming agent is lauryl sodium sulfate, Cocoamidopropyl betaine or dodecanoyl sodium sarcosinate； The preservative is one or more of mixing in triclosan, methyl hydroxybenzoate, ethylparaben, sodium benzoate；The essence For peppermint oil, lemon sesame oil, spearmint oil, orange oil, mandarin oil, wintergreen, caryophyllus oil, cinnamon oil, fennel oil, menthol, dragon One or more of mixing in brain, citral, lauryl aldehyde, vanillic aldehyde, pentyl acetate；Other additives are colouring agent, resisted One or more of mixing of oxidant, pH adjusting agent, taste-modifier, functional additive.
- 5. toothpaste according to claim 4, it is characterised in that：The taste-modifier is xylitol, saccharin sodium, A Siba One or more of mixing of sweet tea, Sucralose, sodium chloride；The colouring agent is chlorophyll, titanium dioxide, allured red pigment, bright orchid At least one of pigment, lemon yellow pigment, pearl essence；The pH adjusting agent is sodium pyrophosphate, sodium dihydrogen phosphate, phosphoric acid hydrogen two One or more of mixing of sodium, sodium carbonate, sodium acid carbonate, sodium metasilicate；The antioxidant be butylated hydroxy anisole (BHA), One or more of mixing of dibutyl hydroxy toluene (BHT), stannous chloride, phytic acid, vitamin C, vitamin E；Described effect adds Add agent for caries preventive agent, desensitizer, anti-inflammation styptic, except stain brightening agent, calculus dentalis inhibitor, flavorants one kind or Several mixing.
- 6. toothpaste according to claim 1, it is characterised in that：The percentage by weight of each component is in the toothpaste prescription 0.001%~10% bismuth glycyrrhetate, 10%~30% NMF, 1%~2% thickener, 40%~60% friction It is agent, 1%~3% foaming agent, 0.5%~1.5% spices, 0.1%~0.5% preservative, other additives 0%~5%, remaining Measure as water.
- 7. toothpaste according to claim 1, it is characterised in that：The percentage by weight of each component is in the toothpaste prescription 0.001%~10% bismuth glycyrrhetate, 35%~65% NMF, 0.2%~1% thickener, 10%~25% rub It is liniment, 1%~2% foaming agent, 0.5%~2% essence, 0.1%~0.5% preservative, other additives 0%~5%, remaining Measure as water.
- 8. toothpaste according to claim 1, it is characterised in that：The percentage by weight of each component is in the toothpaste prescription 0.001%~10% bismuth glycyrrhetate, 40%~80% NMF, 0.5%~1% thickener, 15%~50% rub Liniment, 1%~2% foaming agent, 0.5%~1.5% essence, 0.1%~0.5% preservative, other additives 0%~5%, Water is 0%；The thickener is carbomer；The NMF is polyethylene glycol, glycerine, the mixed liquor of propane diols.
- 9. the preparation method of a kind of toothpaste as described in claim 6-7 is any, it is characterised in that comprise the following steps：1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieves；2) above-mentioned bismuth glycyrrhetate powder, NMF and preservative are mixed and is put into deionized water deionized water made of stirring Solution, thickener, rubbing agent, foaming agent, the mixing of other additives are then added, is sent into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirring Mix and mill 25~40 minutes, vacuum outgas, then add essence and be stirred for mixing in 10~25 minutes of milling, obtain lotion of toothpaste, Pass through sterile filling, packaging.
- 10. a kind of preparation method of toothpaste as claimed in claim 8, it is characterised in that comprise the following steps：1) bismuth glycyrrhetate is crushed, crosses 150-200 mesh sieves；2) carbomer Carbopol is distributed in polyethylene glycol；Glycerine, propane diols NMF are added into carbomer Carbopol- In polyglycol solution, moderate-speed mixer 5-10 minutes, liquid material is made；Then by above-mentioned bismuth glycyrrhetate powder, thickener, friction Agent, foaming agent, the mixing of other additives, are sent into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred is milled 25~40 minutes, and vacuum takes off Gas, then add essence and be stirred for mixing in 10~25 minutes of milling, obtain lotion of toothpaste, pass through sterile filling, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710762697.XA CN107485575A (en) | 2017-08-30 | 2017-08-30 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710762697.XA CN107485575A (en) | 2017-08-30 | 2017-08-30 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107485575A true CN107485575A (en) | 2017-12-19 |
Family
ID=60645656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710762697.XA Withdrawn CN107485575A (en) | 2017-08-30 | 2017-08-30 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107485575A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108125815A (en) * | 2018-02-02 | 2018-06-08 | 高勇 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
| CN109125144A (en) * | 2018-11-01 | 2019-01-04 | 长春健康未来医药科技有限公司 | A kind of toothpaste and its preparation method for preventing canker sore, inhibiting helicobacter pylori |
| CN109549858A (en) * | 2019-01-10 | 2019-04-02 | 乳源南岭好山好水化妆品有限公司 | A kind of gel of tooth-whitening and preparation method thereof |
| CN113559012A (en) * | 2021-08-18 | 2021-10-29 | 南京上元堂沉香生物科技有限公司 | Agilawood toothpaste with function of inhibiting oral helicobacter pylori |
| CN114588064A (en) * | 2022-03-11 | 2022-06-07 | 姜巨波 | SOD rose toothpaste |
| WO2022160718A1 (en) * | 2021-01-28 | 2022-08-04 | 重庆登康口腔护理用品股份有限公司 | Anti-sensitive toothpaste capable of enhancing fluorine activity |
| CN116270336A (en) * | 2022-12-07 | 2023-06-23 | 康博士日化集团有限公司 | Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products |
-
2017
- 2017-08-30 CN CN201710762697.XA patent/CN107485575A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108125815A (en) * | 2018-02-02 | 2018-06-08 | 高勇 | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof |
| CN109125144A (en) * | 2018-11-01 | 2019-01-04 | 长春健康未来医药科技有限公司 | A kind of toothpaste and its preparation method for preventing canker sore, inhibiting helicobacter pylori |
| CN109549858A (en) * | 2019-01-10 | 2019-04-02 | 乳源南岭好山好水化妆品有限公司 | A kind of gel of tooth-whitening and preparation method thereof |
| WO2022160718A1 (en) * | 2021-01-28 | 2022-08-04 | 重庆登康口腔护理用品股份有限公司 | Anti-sensitive toothpaste capable of enhancing fluorine activity |
| CN113559012A (en) * | 2021-08-18 | 2021-10-29 | 南京上元堂沉香生物科技有限公司 | Agilawood toothpaste with function of inhibiting oral helicobacter pylori |
| CN114588064A (en) * | 2022-03-11 | 2022-06-07 | 姜巨波 | SOD rose toothpaste |
| CN116270336A (en) * | 2022-12-07 | 2023-06-23 | 康博士日化集团有限公司 | Composition with antibacterial and anti-inflammatory effects and application thereof in oral care products |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107485575A (en) | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof | |
| EP1437126B1 (en) | Compositions used to alleviate xerostomia and to treat disorders associated with same | |
| US6696047B2 (en) | Stable oral care compositions comprising chlorite | |
| FI104044B (en) | Preparation used for dental care | |
| DE69918806T2 (en) | CHLORINE-CONTAINING MOIST CARE COMPOSITIONS | |
| CN110812316B (en) | Toothpaste containing various traditional Chinese medicine compositions, preparation method and application thereof | |
| CN110087619A (en) | Oral care composition and application method | |
| KR101854418B1 (en) | Toothpaste composition comprising jade ingredient | |
| TW201223554A (en) | Dentifrice composition with reduced astringency | |
| TW201204376A (en) | Compositions to enhance the solubility and delivery of magnolia actives | |
| RU2457829C2 (en) | Mineral and vitamin complex for strengthening tooth enamel, composition for oral cavity hygiene and toothpaste | |
| CN108125815A (en) | A kind of toothpaste of oral cavity helicobacter pylori resistant and anti-caries stomach strengthening function and preparation method thereof | |
| EP2970350B1 (en) | Oral care compositions containing deoxy sugar antimetabolites | |
| CN105213216B (en) | A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof | |
| US11564878B2 (en) | Oral care product formulation | |
| CN107320368A (en) | A kind of adult's toothpaste of the ash containing Chinese mugwort and preparation method thereof | |
| CN108403544A (en) | A kind of Pediatric Oral Emergency care composition and preparation method thereof | |
| KR100815397B1 (en) | Composition of treating teeth | |
| KR102196459B1 (en) | A toothpaste composition with improved antibacterial performance and a toothpaste comprising the composition | |
| CN113318057A (en) | Old people nursing toothpaste and preparation method and application thereof | |
| CN102525833A (en) | Anti-caries mouthwash composition | |
| CN112137928A (en) | Multi-effect toothpaste and preparation method thereof | |
| CN102512336B (en) | Desensitizing toothpaste and desensitizing day-and-night combined toothpaste | |
| CN105726441A (en) | Toothpaste capable of caring tooth enamel and improving gingivae | |
| US20220354774A1 (en) | Toothpaste for preventing cold teeth and periodontal diseases and manufacturing method therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20171219 |