WO2018026779A1 - Modulateurs spiro-lactames des récepteurs nmda et leurs utilisations - Google Patents
Modulateurs spiro-lactames des récepteurs nmda et leurs utilisations Download PDFInfo
- Publication number
- WO2018026779A1 WO2018026779A1 PCT/US2017/044838 US2017044838W WO2018026779A1 WO 2018026779 A1 WO2018026779 A1 WO 2018026779A1 US 2017044838 W US2017044838 W US 2017044838W WO 2018026779 A1 WO2018026779 A1 WO 2018026779A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- compound
- group
- occurrence
- independently selected
- Prior art date
Links
- 0 CC(C(C)O)C(N(*)*)=O Chemical compound CC(C(C)O)C(N(*)*)=O 0.000 description 5
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Definitions
- R 7 is independently selected from the group consisting of H, -Ci-C 6 alkyl, -S(0) w -Ci_ C 3 alkyl, and halogen;
- compounds described herein bind to NMD A receptors expressing certain NR2 subtypes. In some aspects, the compounds described herein bind to one NR2 subtype and not another.
- Ci-C 6 alkyl group examples include, but are not limited to, methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, isobutyl, sec-butyl, icri-butyl, isopentyl, and neopentyl.
- C1-C4 alkyl refers to a straight-chain or branched saturated hydrocarbon containing 1-4 carbon atoms.
- Exemplary alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, 2-methyl-l -propyl, 2- methyl-2-propyl, 2-methyl-l-butyl, 3 -methyl- 1 -butyl, 3-methyl-2-butyl, 2,2-dimethyl-l-propyl, 2-methyl-l -pentyl, 3-methyl-l -pentyl, 4-methyl-l -pentyl, 2-methyl-2-pentyl, 3-methyl-2- pentyl, 4-methyl-2-pentyl, 2,2-dimethyl-l -butyl, 3,3-dimethyl-l-butyl, 2-ethyl-l -butyl, butyl, isobutyl, t-butyl, pentyl, isopentyl, neopentyl, and hexyl.
- cyano refers to the radical -CN.
- cycloalkyl refers to a monocyclic saturated or partially unsaturated hydrocarbon ring (carbocyclic) system, for example, where each ring is either completely saturated or contains one or more units of unsaturation, but where no ring is aromatic.
- a cycloalkyl can have 3-6 or 4-6 carbon atoms in its ring system, referred to herein as C3-C 6 cycloalkyl or C4-C 6 cycloalkyl, respectively.
- Exemplary cycloalkyl groups include, but are not limited to, cyclohexyl, cyclohexenyl, cyclopentyl, cyclopentenyl, cyclobutyl, and cyclopropyl.
- the disclosure also embraces isotopically-labeled compounds which are identical to those compounds recited herein, except that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature.
- isotopes that can be incorporated into compounds described herein include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, fluorine and chlorine, such as 2 H ("D"), 3 H, 13 C, 14 C, 15 N, 18 0, 17 0, 31 P, 32 P, 35 S, 18 F, and 36 C1, respectively.
- a compound described herein can have one or more H atoms replaced with deuterium.
- compositions that are basic in nature are capable of forming a wide variety of salts with various inorganic and organic acids.
- the acids that can be used to prepare pharmaceutically acceptable acid addition salts of such basic compounds are those that form non-toxic acid addition salts, i.e., salts containing pharmacologically acceptable anions, including but not limited to, malate, oxalate, chloride, bromide, iodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, isonicotinate, acetate, lactate, salicylate, citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfon
- the compounds disclosed herein can exist in a solvated form as well as an unsolvated form with pharmaceutically acceptable solvents such as water, ethanol, and the like, and it is intended that the disclosure embrace both solvated and unsolvated forms.
- pharmaceutically acceptable solvents such as water, ethanol, and the like
- R 6 represents one or two optional substitutions each on one or more available ring carbons, and is independently selected for each occurrence from the group consisting of Ci-C 6 alkyl, -S(0) w -Ci_C 3 alkyl, -NR a R b and halogen;
- w 0, 1, or 2;
- R 3 is selected from the group consisting of H, phenyl, Ci-C 6 alkyl, -C(0)R 31 and - C(0)OR 32 ;
- R 31 and R 32 are each independently H, Ci-Cealkyl, -C 3 -Cecycloalkyl, and phenyl;
- R a and R b are each independently for each occurrence selected from the group consisting of H, phenyl, and Ci-C 3 alkyl, or R a and R b taken together with the nitrogen to which they are attached form a 4-6 membered heterocyclic ring;
- R 1 can be C(0)-Ci-C 6 alkyl, where C(0)-Ci-C 6 alkyl can be represented by:
- R 3 can be H. In certain embodiments, R 3 can be selected from the group consisting of
- EXAMPLE 4 Following the above procedures, the following compounds were or are prepared. It should be appreciated that the compound in the first column is a different stereoisomer, for example, a different enantiomer and/or different diastereomer, from the compound in the second column.
- Sprague Dawley rats were dosed intravenously using a normal saline formulation containing 2 mg/kg of the compounds identified in the below table (except for the first four compounds that were delivered in 5 % NMP, 5% Solutol ® HS and 90 % normal saline formulation).
- the table below summarizes the results of the IV pharmacokinetics.
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019505213A JP2019527233A (ja) | 2016-08-01 | 2017-08-01 | スピロ−ラクタムnmda受容体修飾因子及びその使用 |
SG11201900443VA SG11201900443VA (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam nmda receptor modulators and uses thereof |
EA201990424A EA201990424A1 (ru) | 2016-08-01 | 2017-08-01 | Спиролактамовые модуляторы nmda-рецептора и их применение |
BR112019001768A BR112019001768A2 (pt) | 2016-08-01 | 2017-08-01 | moduladores do receptor de spiro-lactamas nmda e usos dos mesmos |
CN201780048099.4A CN109937204B (zh) | 2016-08-01 | 2017-08-01 | 螺-内酰胺nmda受体调节剂及其用途 |
KR1020197005666A KR102465758B1 (ko) | 2016-08-01 | 2017-08-01 | 스피로-락탐 nmda 수용체 조정제 및 그의 용도 |
AU2017306152A AU2017306152A1 (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam NMDA receptor modulators and uses thereof |
MX2019001319A MX2019001319A (es) | 2016-08-01 | 2017-08-01 | Moduladores del receptor nmda espiro-lactam y uso de los mismos. |
EP17751544.2A EP3490992B1 (fr) | 2016-08-01 | 2017-08-01 | Modulateurs spiro-lactames des récepteurs nmda et leurs utilisations |
US16/321,905 US11299495B2 (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam NMDA receptor modulators and uses thereof |
CA3031537A CA3031537A1 (fr) | 2016-08-01 | 2017-08-01 | Modulateurs spiro-lactames des recepteurs nmda et leurs utilisations |
IL264514A IL264514B (en) | 2016-08-01 | 2019-01-28 | Spiro-lactam nmda receptor modulators and their uses |
PH12019500202A PH12019500202A1 (en) | 2016-08-01 | 2019-01-28 | Spiro-lactam nmda receptor modulators and uses thereof |
CONC2019/0000945A CO2019000945A2 (es) | 2016-08-01 | 2019-01-30 | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
US17/401,653 US11530223B2 (en) | 2016-08-01 | 2021-08-13 | Spiro-lactam NMDA receptor modulators and uses thereof |
AU2021240150A AU2021240150A1 (en) | 2016-08-01 | 2021-09-28 | Spiro-lactam NMDA receptor modulators and uses thereof |
JP2022092387A JP7448766B2 (ja) | 2016-08-01 | 2022-06-07 | スピロ-ラクタムnmda受容体修飾因子及びその使用 |
US18/055,095 US20230312591A1 (en) | 2016-08-01 | 2022-11-14 | Spiro-lactam nmda receptor modulators and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662369453P | 2016-08-01 | 2016-08-01 | |
US62/369,453 | 2016-08-01 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/321,905 A-371-Of-International US11299495B2 (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam NMDA receptor modulators and uses thereof |
US17/401,653 Division US11530223B2 (en) | 2016-08-01 | 2021-08-13 | Spiro-lactam NMDA receptor modulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2018026779A1 true WO2018026779A1 (fr) | 2018-02-08 |
Family
ID=59582038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2017/044838 WO2018026779A1 (fr) | 2016-08-01 | 2017-08-01 | Modulateurs spiro-lactames des récepteurs nmda et leurs utilisations |
Country Status (17)
Country | Link |
---|---|
US (3) | US11299495B2 (fr) |
EP (1) | EP3490992B1 (fr) |
JP (2) | JP2019527233A (fr) |
KR (1) | KR102465758B1 (fr) |
CN (1) | CN109937204B (fr) |
AU (2) | AU2017306152A1 (fr) |
BR (1) | BR112019001768A2 (fr) |
CA (1) | CA3031537A1 (fr) |
CL (1) | CL2019000248A1 (fr) |
CO (1) | CO2019000945A2 (fr) |
EA (1) | EA201990424A1 (fr) |
IL (1) | IL264514B (fr) |
MX (1) | MX2019001319A (fr) |
PE (1) | PE20190503A1 (fr) |
PH (1) | PH12019500202A1 (fr) |
SG (2) | SG11201900443VA (fr) |
WO (1) | WO2018026779A1 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10150769B2 (en) | 2016-08-01 | 2018-12-11 | Aptinyx Inc. | Spiro-lactam NMDA modulators and methods of using same |
CN109608460A (zh) * | 2018-12-17 | 2019-04-12 | 上海合全药业股份有限公司 | 一种1,10-二氧亚基-2,7-二氮杂螺[4.5]癸烷-7-甲酸叔丁酯的合成方法 |
WO2019152687A1 (fr) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactame modulateur des récepteurs nmda et leurs utilisations |
US10441571B2 (en) | 2013-01-29 | 2019-10-15 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US10906913B2 (en) | 2008-09-18 | 2021-02-02 | Northwestern University | NMDA receptor modulators and uses thereof |
US10918637B2 (en) | 2016-08-01 | 2021-02-16 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US10961189B2 (en) | 2016-08-01 | 2021-03-30 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US11028095B2 (en) | 2016-08-01 | 2021-06-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
US11299495B2 (en) | 2016-08-01 | 2022-04-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023525860A (ja) * | 2020-05-12 | 2023-06-19 | ベイジン・グレートウェイ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | Nmda受容体の活性を調節する化合物、その医薬組成物及び使用 |
CN114591326B (zh) * | 2022-02-28 | 2024-02-27 | 上海筛杰生物医药有限公司 | Cct-251921的中间体及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014120800A1 (fr) * | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Modulateurs spirolactames d'un récepteur nmda et leurs utilisations |
WO2014120789A1 (fr) * | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Modulateurs spirolactames d'un récepteur nmda et leurs utilisations |
WO2014120786A1 (fr) * | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Modulateurs spirolactames d'un récepteur nmda et leurs utilisations |
Family Cites Families (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0180398A1 (fr) | 1984-10-26 | 1986-05-07 | The Regents Of The University Of California | Synthèse de bêta-lactame |
CA1305177C (fr) | 1987-06-30 | 1992-07-14 | Yasufumi Ohfune | Carboxypropylglycine et procede pour sa production |
US4904681A (en) | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
EP0360390A1 (fr) | 1988-07-25 | 1990-03-28 | Glaxo Group Limited | Dérivés de spirolactames |
US5061721A (en) | 1989-03-15 | 1991-10-29 | G. D. Searle & Co. | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
US5086072A (en) | 1990-06-18 | 1992-02-04 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex |
CA2058975C (fr) | 1990-10-30 | 2000-06-06 | Shuichi Kasai | Preparation antiinflammatoire sous forme de gel |
US5168103A (en) | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
FR2692268B1 (fr) | 1992-06-15 | 1994-08-19 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activité de récepteur NMDA, acides nucléiques codant pour ces polypeptides et utilisations. |
SE9301667D0 (sv) | 1993-05-14 | 1993-05-14 | Kabi Pharmacia Ab | New use |
US5523323A (en) | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
US5605911A (en) | 1995-01-31 | 1997-02-25 | Washington University | Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH) |
US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
US5741778A (en) | 1996-03-19 | 1998-04-21 | Amgen Inc. | Method for treating Huntington's disease using glial cell line-derived neurotrophic factor (GDNF) protein product |
US5763393A (en) | 1996-05-17 | 1998-06-09 | Neurotherapeutics L.P. | Neuroactive peptides |
WO1997046578A1 (fr) | 1996-06-07 | 1997-12-11 | Zeneca Limited | Derives de peptides |
AU3972797A (en) | 1996-08-02 | 1998-02-25 | Zymogenetics Inc. | Testis-specific insulin homolog polypeptides |
US5902815A (en) | 1996-09-03 | 1999-05-11 | Washington University | Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction |
JP3955345B2 (ja) | 1996-09-27 | 2007-08-08 | サントリー株式会社 | 新規アミノ酸ダイジハーベイン |
AU1585999A (en) | 1997-11-12 | 1999-05-31 | Neurotherapeutics | Methods for the detection and treatment of disease using a glycosyltransferase |
US5952389A (en) | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
US6007841A (en) | 1998-03-13 | 1999-12-28 | Algos Pharmaceutical Corporation | Analgesic composition and method for treating pain |
US6274314B1 (en) | 1998-04-02 | 2001-08-14 | Nyxis Neurotherapies, Inc. | Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine |
US6197820B1 (en) | 1998-04-06 | 2001-03-06 | Uab Research Foundation | Use of phenylglycine derivatives to decrease neuronal death caused by brain tumors and brain lesions |
US6025471A (en) | 1998-06-03 | 2000-02-15 | Deghenghi; Romano | Diazaspiro, azepino and azabicyclo therapeutic peptides |
WO2000027790A1 (fr) | 1998-11-11 | 2000-05-18 | Smithkline Beecham P.L.C. | Composes a base de mutiline |
AU1724000A (en) | 1998-11-12 | 2000-05-29 | Nyxis, Inc. | Diagnostic assay for cancer |
US20030064921A1 (en) | 1999-10-27 | 2003-04-03 | The Regents Of The University Of California | Methods and compounds for modulating melanocortin receptor ligand binding and activity |
AU1922301A (en) | 1999-11-17 | 2001-05-30 | Nyxis Neurotherapies, Inc. | Differential gene expression in cancer |
US6521414B2 (en) | 2000-02-01 | 2003-02-18 | Agy Therapeutics, Inc. | Methods for identifying a modulator of the interaction of NMDA receptor with protein tyrosine phosphatase L1 |
JP2001261679A (ja) | 2000-03-21 | 2001-09-26 | Mitsui Chemicals Inc | ピロリジノン誘導体及びそれらの製造方法並びに該化合物を含有する医薬 |
WO2001096606A2 (fr) | 2000-06-14 | 2001-12-20 | Nyxis Neurotherapies, Inc. | Identification de genes et de composes pour le traitement du cancer |
EP1296999A2 (fr) | 2000-06-22 | 2003-04-02 | NYXIS NeuroTherapies, Inc. | Peptides neuroactifs servant a traiter l'hypoxie et des etats apparentes |
GB0018272D0 (en) | 2000-07-25 | 2000-09-13 | Vernalis Research Limited | Chemical compounds IV |
IL145209A0 (en) | 2000-09-06 | 2002-06-30 | Pfizer Prod Inc | Pharmaceutical combinations for the treatment of stroke and traumatic brain injury |
EP1186303A3 (fr) | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Combinaisons pharmaceutiques pour le traitement des accidents cerebrovasculaires, contenant un facteur inhibitant la neutrophile et un antagoniste selectif du NMDA-NR2B |
UA73619C2 (en) | 2000-12-13 | 2005-08-15 | Pfizer Prod Inc | Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment |
AU2002236608A1 (en) | 2000-12-14 | 2002-06-24 | Nyxis Neurotherapies, Inc. | High throughput assay to detect inhibitors of the map kinase pathway |
AU2002248553A1 (en) | 2001-03-07 | 2002-09-24 | Cognetix, Inc | Linear y-carboxyglutamate rich conotoxins |
AU2002255705A1 (en) | 2001-03-12 | 2002-09-24 | Nyxis Neurotherapies, Inc | Neuroactive peptides for prevention and/or treatment of hypoxia and neuropathic pain |
WO2003010540A1 (fr) | 2001-07-25 | 2003-02-06 | Nyxis Neurotherapies, Inc. | Procede d'identification d'un agent lie au nmda |
NZ537214A (en) | 2002-07-05 | 2007-08-31 | Targacept Inc | N-Aryl diazaspiracyclic compounds capable of affecting nicotinic cholinergic receptors and methods of preparation and use thereof |
US7273889B2 (en) | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
AU2004232939A1 (en) | 2003-04-17 | 2004-11-04 | Merck Sharp & Dohme Corp. | Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity |
EP1776362A1 (fr) | 2003-07-18 | 2007-04-25 | Virochem Pharma Inc. | Composes spiro et procedes pour moduler une activite de recepteur de chimiokime |
US7544478B2 (en) | 2003-08-08 | 2009-06-09 | The Burnham Institute | Method for screening for compounds that modulate P16 mediated regulation of NMDA receptors |
WO2005020973A2 (fr) | 2003-08-29 | 2005-03-10 | The University Of Houston System | Compositions a activite antimycobacterienne comprenant un hydroxamate ou un hydroxamate et une hydroxylamine |
GB0323204D0 (en) | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
US20050096311A1 (en) | 2003-10-30 | 2005-05-05 | Cns Response | Compositions and methods for treatment of nervous system disorders |
WO2005047286A1 (fr) | 2003-11-13 | 2005-05-26 | Ono Pharmaceutical Co., Ltd. | Compose spiranique heterocyclique |
BRPI0418375A (pt) * | 2004-01-08 | 2007-05-22 | Hoffmann La Roche | derivados de diaza-espiropiperidina |
JP2008510711A (ja) * | 2004-08-20 | 2008-04-10 | ターガセプト,インコーポレイテッド | 嗜癖治療におけるn−アリールジアザスピラ環状化合物の使用 |
US20060063707A1 (en) | 2004-09-17 | 2006-03-23 | Lifelike Biomatic, Inc. | Compositions for enhancing memory and methods therefor |
CN101090902B (zh) * | 2004-10-13 | 2013-05-29 | 默沙东公司 | Cgrp受体拮抗剂 |
EP2431042B1 (fr) | 2005-03-24 | 2013-06-26 | Emory University | Procédés pour le traitement des blessures du système nerveux central via un protocole d'administration biseauté |
EP1945691A2 (fr) | 2005-08-26 | 2008-07-23 | Wisconsin Alumni Research Foundation | Poly-beta-peptides a partir de monomeres de beta-lactame fonctionnalises ainsi que compositions antibacteriennes contenant ceux-ci |
AR059224A1 (es) | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
US20070208001A1 (en) | 2006-03-03 | 2007-09-06 | Jincong Zhuo | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
WO2008033464A2 (fr) | 2006-09-15 | 2008-03-20 | Schering Corporation | Dérivés d'azétidinone et procédés d'utilisation de ceux-ci |
JP2008188285A (ja) | 2007-02-06 | 2008-08-21 | Bridgestone Corp | バックパッド及び車両用シート |
CN101675041A (zh) | 2007-03-20 | 2010-03-17 | 沃泰克斯药物股份有限公司 | 用作激酶抑制剂的氨基嘧啶类化合物 |
CN101066945B (zh) | 2007-05-25 | 2010-05-19 | 中国科学院上海有机化学研究所 | 一种合成3-位取代内酰胺类化合物的方法 |
CN101125817B (zh) | 2007-08-03 | 2011-09-14 | 中国科学院上海有机化学研究所 | 一种合成高对映选择性醛基取代小环胺类化合物和光学活性3-位取代内酰胺类化合物的方法 |
US20090054392A1 (en) | 2007-08-20 | 2009-02-26 | Wyeth | Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system |
WO2009039390A2 (fr) | 2007-09-20 | 2009-03-26 | Naurex Inc. | Développement de procédés thérapeutiques à base de glycobiologie pour le traitement de tumeurs cérébrales |
WO2009105718A1 (fr) | 2008-02-20 | 2009-08-27 | The Children's Hospital Of Philadelphia | Modifications génétiques associées à l'autisme et au phénotype autistique et procédés d'utilisation de celles-ci pour le diagnostic et le traitement de l'autisme |
BRPI0914687A2 (pt) | 2008-06-24 | 2015-10-20 | Intervet Int Bv | preparação veterinária por derramamento, métodos para tratar condições inflamatórias e para administrar a preparação veterinária por derramamento, e, uso da preparação veterinária por derramamento |
EP2313394A1 (fr) | 2008-06-27 | 2011-04-27 | NeuroSearch A/S | Nouveaux dérivés de la pipéridine à substitution par un tétraméthyle et leur utilisation comme inhibiteurs de la recapture des neurotransmetteurs de monoamine |
CA2732091A1 (fr) | 2008-08-07 | 2010-02-11 | F. Hoffmann-La Roche Ag | Procede pour la preparation d'un macrocycle |
GB0814991D0 (en) | 2008-08-15 | 2008-09-24 | Glaxo Group Ltd | Compounds |
CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
WO2010065709A2 (fr) | 2008-12-03 | 2010-06-10 | Amin Khan | Dérivés d'acide hydroxamique, préparation et utilisations thérapeutiques de ceux-ci |
DE102009001460B4 (de) | 2009-03-11 | 2010-12-02 | Zf Friedrichshafen Ag | Ölbehälter |
US8329904B2 (en) | 2009-05-12 | 2012-12-11 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
US20120178695A1 (en) | 2009-07-02 | 2012-07-12 | Joseph Moskal | Methods of treating neuropathic pain |
US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
PL2985032T3 (pl) | 2009-10-05 | 2019-07-31 | Northwestern University | Glyx do stosowania do leczenia choroby alzheimera, choroby parkinsona lub choroby huntingtona |
US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
EP2516439B1 (fr) | 2009-12-21 | 2014-01-22 | Novartis AG | Diaza-spiro[5.5]undécanes en tant qu'antagonistes de récepteurs d'orexine |
KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
CN102933226A (zh) | 2010-02-11 | 2013-02-13 | 西北大学 | 二级结构稳定化的nmda受体调节剂及其用途 |
UY33227A (es) * | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
US8097634B2 (en) | 2010-04-15 | 2012-01-17 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
GB201007789D0 (en) * | 2010-05-10 | 2010-06-23 | Glaxo Group Ltd | Novel Compound |
CN102267995A (zh) | 2010-06-04 | 2011-12-07 | 艾琪康医药科技(上海)有限公司 | 一种制备二氮杂螺环化合物的方法 |
AR082633A1 (es) | 2010-08-12 | 2012-12-19 | Tetraphase Pharmaceuticals Inc | Analogos de tetraciclina |
US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
CA2828219A1 (fr) | 2011-02-25 | 2012-08-30 | Irm Llc | Composes et compositions en tant qu'inhibiteurs de trk |
HUE036408T2 (hu) * | 2011-03-14 | 2018-07-30 | Boehringer Ingelheim Int | A leukotrién-termelés benzodioxán inhibitorai |
KR20140043078A (ko) | 2011-04-27 | 2014-04-08 | 노오쓰웨스턴 유니버시티 | 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법 |
US9293690B2 (en) | 2011-06-27 | 2016-03-22 | Koninklijke Philips N.V. | Ultrasound transducer assembly and method of manufacturing the same |
CA2842647A1 (fr) | 2011-07-18 | 2013-01-24 | The Governors Of The University Of Alberta | Catalyseurs et procedes destines a l'hydrogenation d'amides |
PL3686194T3 (pl) | 2011-07-27 | 2022-01-17 | Astrazeneca Ab | Związki 2-(2,4,5-podstawione-anilino)pirymidynowe |
EP2796451B1 (fr) | 2011-12-20 | 2018-08-01 | Wei Qian | Dérivé hétérocyclique de quinazoline substitué par un amido-alkyloxy et son utilisation |
AR092031A1 (es) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
CN102936216B (zh) | 2012-12-05 | 2015-03-04 | 南京药石药物研发有限公司 | 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法 |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
CA2898861C (fr) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Modulateurs spirolactames d'un recepteur nmda et leurs utilisations |
CN103171641B (zh) | 2013-03-19 | 2015-07-15 | 浙江大学 | 具备轮动功能的弹跳机器人 |
JO3517B1 (ar) * | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
GB2528480A (en) | 2014-07-23 | 2016-01-27 | Givaudan Sa | Improvements in or relating to organic compounds |
GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
CA3024606C (fr) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Modulateurs de recepteurs nmda de spiro-lactame et utilisations associees |
WO2017201285A1 (fr) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Modulateurs spirolactames des récepteurs nmda et leurs utilisations |
PE20190503A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
WO2018026763A1 (fr) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Modulateurs spiro-lactames des récepteurs nmda et leurs utilisations |
CA3031539C (fr) | 2016-08-01 | 2023-11-28 | Aptinyx Inc. | Modulateurs spirolactames des recepteurs nmda et leurs utilisations |
BR112019001926A2 (pt) | 2016-08-01 | 2019-08-06 | Aptinyx Inc | moduladores do receptor nmda espiro-lactama e bis-espiro-lactama e usos destes |
EP3490990B1 (fr) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Modulateurs nmda a base de spirolactams et leur methode d'utilisation |
PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
SG11202007251XA (en) | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
US20210139489A1 (en) | 2019-11-11 | 2021-05-13 | Aptinyx Inc. | Methods of treating painful diabetic peripheral neuropathy |
US20210308101A1 (en) | 2019-11-11 | 2021-10-07 | Aptinyx Inc. | Methods of treating fibromyalgia |
KR20220110251A (ko) | 2019-12-04 | 2022-08-05 | 앱티닉스 인크. | 신경변성 질환과 연관된 인지 장애를 치료하는 방법 |
-
2017
- 2017-08-01 PE PE2019000296A patent/PE20190503A1/es unknown
- 2017-08-01 CA CA3031537A patent/CA3031537A1/fr active Pending
- 2017-08-01 EP EP17751544.2A patent/EP3490992B1/fr active Active
- 2017-08-01 AU AU2017306152A patent/AU2017306152A1/en not_active Abandoned
- 2017-08-01 WO PCT/US2017/044838 patent/WO2018026779A1/fr unknown
- 2017-08-01 MX MX2019001319A patent/MX2019001319A/es unknown
- 2017-08-01 SG SG11201900443VA patent/SG11201900443VA/en unknown
- 2017-08-01 JP JP2019505213A patent/JP2019527233A/ja active Pending
- 2017-08-01 EA EA201990424A patent/EA201990424A1/ru unknown
- 2017-08-01 US US16/321,905 patent/US11299495B2/en active Active
- 2017-08-01 SG SG10202101055VA patent/SG10202101055VA/en unknown
- 2017-08-01 CN CN201780048099.4A patent/CN109937204B/zh active Active
- 2017-08-01 KR KR1020197005666A patent/KR102465758B1/ko active IP Right Grant
- 2017-08-01 BR BR112019001768A patent/BR112019001768A2/pt active Search and Examination
-
2019
- 2019-01-28 PH PH12019500202A patent/PH12019500202A1/en unknown
- 2019-01-28 IL IL264514A patent/IL264514B/en unknown
- 2019-01-30 CL CL2019000248A patent/CL2019000248A1/es unknown
- 2019-01-30 CO CONC2019/0000945A patent/CO2019000945A2/es unknown
-
2021
- 2021-08-13 US US17/401,653 patent/US11530223B2/en active Active
- 2021-09-28 AU AU2021240150A patent/AU2021240150A1/en not_active Abandoned
-
2022
- 2022-06-07 JP JP2022092387A patent/JP7448766B2/ja active Active
- 2022-11-14 US US18/055,095 patent/US20230312591A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014120800A1 (fr) * | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Modulateurs spirolactames d'un récepteur nmda et leurs utilisations |
WO2014120789A1 (fr) * | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Modulateurs spirolactames d'un récepteur nmda et leurs utilisations |
WO2014120786A1 (fr) * | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Modulateurs spirolactames d'un récepteur nmda et leurs utilisations |
Non-Patent Citations (10)
Title |
---|
BURGDORF ET AL.: "Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors", NEUROSCIENCE, vol. 192, 2011, pages 515 - 523, XP028279417, DOI: doi:10.1016/j.neuroscience.2011.05.001 |
BURGDORF ET AL.: "The effect of selective breeding for differential rates of 50-kHz ultrasonic vocalizations on emotional behavior in rats", DEVEL. PSYCHOBIOL., vol. 51, 2009, pages 34 - 46 |
BURGDORF ET AL.: "The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus", NEUROSCIENCE, vol. 308, 2015, pages 202 - 211, XP029289248, DOI: doi:10.1016/j.neuroscience.2015.09.004 |
CARREIRA; KVAERNO: "Classics in Stereoselective Synthesis", 2009, WILEY-VCH: WEINHEIM |
COLLINGRIDGE ET AL.: "The NMDA Receptor", 1994, OXFORD UNIVERSITY PRESS |
FOSTER ET AL., NATURE, vol. 329, 1987, pages 395 - 396 |
MAYER ET AL., TRENDS IN PHARMACOL. SCI., vol. 11, 1990, pages 254 - 260 |
MOSKAL ET AL.: "GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator", NEUROPHARMACOLOGY, vol. 49, 2005, pages 1077 - 87, XP026192890, DOI: doi:10.1016/j.neuropharm.2005.06.006 |
RAUTIO, KUMPULAINEN ET AL., NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 255 |
SIMPLFCIO ET AL., MOLECULES, vol. 13, 2008, pages 519 |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10906913B2 (en) | 2008-09-18 | 2021-02-02 | Northwestern University | NMDA receptor modulators and uses thereof |
US10441572B2 (en) | 2013-01-29 | 2019-10-15 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US11077094B2 (en) | 2013-01-29 | 2021-08-03 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US10441571B2 (en) | 2013-01-29 | 2019-10-15 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US10961189B2 (en) | 2016-08-01 | 2021-03-30 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US11299495B2 (en) | 2016-08-01 | 2022-04-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US11530223B2 (en) | 2016-08-01 | 2022-12-20 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US10918637B2 (en) | 2016-08-01 | 2021-02-16 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US10150769B2 (en) | 2016-08-01 | 2018-12-11 | Aptinyx Inc. | Spiro-lactam NMDA modulators and methods of using same |
US11028095B2 (en) | 2016-08-01 | 2021-06-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
US11512051B2 (en) | 2016-08-01 | 2022-11-29 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US11427585B2 (en) | 2016-08-01 | 2022-08-30 | Aptinyx Inc. | Spiro-lactam NMDA modulators and methods of using same |
US11370790B2 (en) | 2016-08-01 | 2022-06-28 | Aptinyx Inc. | Spiro-lactam NMDA modulators and methods of using same |
US11376250B2 (en) | 2016-08-01 | 2022-07-05 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CN112204031A (zh) * | 2018-01-31 | 2021-01-08 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
WO2019152687A1 (fr) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactame modulateur des récepteurs nmda et leurs utilisations |
US11578072B2 (en) * | 2018-01-31 | 2023-02-14 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CN109608460A (zh) * | 2018-12-17 | 2019-04-12 | 上海合全药业股份有限公司 | 一种1,10-二氧亚基-2,7-二氮杂螺[4.5]癸烷-7-甲酸叔丁酯的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
IL264514A (en) | 2019-02-28 |
AU2021240150A1 (en) | 2021-10-28 |
IL264514B (en) | 2021-09-30 |
KR20190033595A (ko) | 2019-03-29 |
KR102465758B1 (ko) | 2022-11-09 |
PH12019500202A1 (en) | 2019-07-29 |
US20230312591A1 (en) | 2023-10-05 |
CL2019000248A1 (es) | 2019-06-21 |
EP3490992B1 (fr) | 2023-03-22 |
MX2019001319A (es) | 2019-07-04 |
CA3031537A1 (fr) | 2018-02-08 |
US11530223B2 (en) | 2022-12-20 |
CN109937204B (zh) | 2022-11-25 |
BR112019001768A2 (pt) | 2019-06-11 |
SG11201900443VA (en) | 2019-02-27 |
SG10202101055VA (en) | 2021-03-30 |
JP2019527233A (ja) | 2019-09-26 |
PE20190503A1 (es) | 2019-04-10 |
CN109937204A (zh) | 2019-06-25 |
CO2019000945A2 (es) | 2019-02-08 |
EA201990424A1 (ru) | 2019-08-30 |
US11299495B2 (en) | 2022-04-12 |
US20190177334A1 (en) | 2019-06-13 |
AU2017306152A1 (en) | 2019-01-31 |
JP7448766B2 (ja) | 2024-03-13 |
EP3490992A1 (fr) | 2019-06-05 |
US20220220119A1 (en) | 2022-07-14 |
JP2022120019A (ja) | 2022-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11530223B2 (en) | Spiro-lactam NMDA receptor modulators and uses thereof | |
US11427585B2 (en) | Spiro-lactam NMDA modulators and methods of using same | |
US11376250B2 (en) | Spiro-lactam NMDA receptor modulators and uses thereof | |
AU2017306136B2 (en) | Spiro-lactam NMDA receptor modulators and uses thereof | |
WO2019152685A1 (fr) | Spiro-lactame modulateur des récepteurs nmda et leurs procédés d'utilisation | |
WO2019152688A1 (fr) | Spiro-lactame modulateur de récepteurs nmda et leurs utilisations |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 17751544 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 3031537 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2019505213 Country of ref document: JP Kind code of ref document: A Ref document number: 2017306152 Country of ref document: AU Date of ref document: 20170801 Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: 112019001768 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: 20197005666 Country of ref document: KR Kind code of ref document: A |
|
ENP | Entry into the national phase |
Ref document number: 2017751544 Country of ref document: EP Effective date: 20190301 |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01E Ref document number: 112019001768 Country of ref document: BR Free format text: APRESENTAR O RELATORIO DESCRITIVO. |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01Y Ref document number: 112019001768 Country of ref document: BR Kind code of ref document: A2 Free format text: ANULADA A PUBLICACAO CODIGO 1.5 NA RPI NO 2522 DE 07/05/2019 POR TER SIDO INDEVIDA. |
|
ENP | Entry into the national phase |
Ref document number: 112019001768 Country of ref document: BR Kind code of ref document: A2 Effective date: 20190129 |