WO2017209382A1 - 체중 증가 촉진용 사료 첨가제, 가축용 사료 조성물 및 가축 사육 방법 - Google Patents
체중 증가 촉진용 사료 첨가제, 가축용 사료 조성물 및 가축 사육 방법 Download PDFInfo
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- WO2017209382A1 WO2017209382A1 PCT/KR2017/003077 KR2017003077W WO2017209382A1 WO 2017209382 A1 WO2017209382 A1 WO 2017209382A1 KR 2017003077 W KR2017003077 W KR 2017003077W WO 2017209382 A1 WO2017209382 A1 WO 2017209382A1
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- feed
- weight
- livestock
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- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Definitions
- the present invention relates to a feed additive for accelerating weight gain, a feed composition for livestock, and a method for raising livestock, which can be absorbed directly without being accumulated in a livestock body and used as a source of energy rapidly.
- Feeds refer to materials that supply organic (organic) or inorganic (inorganic) nutrients necessary to maintain the life of livestock and to produce milk, meat, eggs, fur and leather. It is a mixture of nutrients such as energy, protein, vitamins and minerals required by various livestock, as well as growth promoters and disease prevention agents.
- Feeds do diverse roles, such as supplying nutrients for survival and production of livestock by ingestion of livestock, enhancing immune function, improving the quality of livestock products, and improving the housing environment.
- the increase in productivity of livestock is achieved by improving the environment of the housing or improving the feed efficiency.
- various methods of adding a new composition to the existing feed composition, changing the composition ratio have.
- Korean Patent Laid-Open Publication No. 2006-35444 discloses an animal feed and an animal feed method using the animal feed.
- the animal feed includes general animal feed and bamboo charcoal, and increases the body weight or weight gain.
- Fat is one of the essential nutrients of livestock. It has higher energy than other nutrients and is the most expensive energy source per unit weight. Therefore, when the utilization efficiency of the fat in the body is improved, not only the productivity of the livestock can be improved but also the opportunity to reduce the production cost by reducing the raw material cost of the feed can be provided.
- a diglyceride is a fat composition in which a fatty acid is bonded to glycerin at the first, second or first and third positions by ester exchange reaction between a fatty acid and glycerin, and is handled as a special separation from a general fat called 'triglyceride' .
- 2007-512407 proposes that a fat composition containing a large amount of diglycerides composed of conjugated linoleic acid for the purpose of prevention of accumulation of body fat, prevention of disease and nutrient supply can be used as a food, a pharmaceutical composition and a feed additive .
- Japanese Patent Application Laid-Open No. 1996-269478 discloses a fat composition containing 31% by weight or more of triglyceride containing two C8-C10 heavy chain fatty acid residues in a molecule. The fat composition has a higher metabolism than a commonly used cooking oil, The accumulation is small.
- Japanese Laid-Open Patent Publication No. 1993-56755 discloses a feed additive for livestock and a feed for livestock, and it is disclosed that using 6-12 carbon heavy chain fatty acid triglycerides can suppress the occurrence of chicken coccidiosis and inhibit accumulation of abnormal body fat .
- Patent Document 1 Korean Patent Publication No. 2006-35444
- Patent Document 2 Korean Patent No. 10-0740564
- Patent Document 3 Japanese Laid-Open Patent Application No. 2007-512407
- An object of the present invention is to provide a feed additive for promoting weight gain, which can be used as an energy source without being accumulated as fat when fed to livestock as a fat source, thereby promoting the growth of livestock and improving productivity, a feed composition for livestock, .
- Triglyceride monoglyceride, free fatty acid or a mixture thereof
- the content of 1,3-diglyceride in the diglyceride is 40% by weight or more
- the content of the fatty acid having 14 or less carbon atoms in the constituent fatty acids of the diglyceride is 70 to 90% by weight, the content of the fatty acid having 16 or more carbon atoms is 10 to 30%
- the present invention provides a feed additive for promoting weight gain, wherein the content of a fatty acid having 14 or less carbon atoms relative to a fatty acid bonded to the 1,3-position of the constituent fatty acids of the diglycerides is 60 to 80% by weight.
- the present invention also provides a feed composition for livestock comprising the above-described feed additive for promoting weight gain and a compounded feed.
- the present invention also provides a method of raising a livestock, characterized in that the animal feed composition is fed.
- the present invention also provides a feed composition for livestock which is substituted with 40 to 60% by weight of the fat source in the compound feed as the above-mentioned feed additive for promoting weight gain.
- the present invention also provides a method of raising a livestock, characterized in that the animal feed composition is fed.
- the feed additive for promoting weight gain according to the present invention can be used as an energy source without being accumulated in fat during fat metabolism in a livestock body to promote the growth of livestock and improve productivity.
- FIG. 1 is a graph showing the body weight and the body weight gain of the flounder at the end of the experiment of Experimental Example 4 for confirming the effect of the addition of the feed additive for accelerating weight gain of the present invention on the flounder.
- FIG. 2 is a graph showing the growth rate and feed intake rate of the flounder in Experimental Example 4 for confirming the effect of the addition of the feed additive for accelerating weight gain of the present invention on the flounder rearing.
- FIG. 3 is a graph showing flounder feed conversion and protein utilization efficiency of Experimental Example 4 for confirming the effect of the addition of the feed additive for promoting weight gain of the present invention on the flounder rearing.
- FIG. 4 is a graph showing the survival rate of the flounder in Experimental Example 4 for confirming the effect of the feed additive supplementation promoting weight gain of the present invention on the flounder rearing.
- FIG. 5 is a graph showing the body weight and the body weight gain of the flounder at the end of the experiment of Experimental Example 5 to confirm the effect of the addition of the feed additive for promoting weight gain of the present invention on the flounder.
- FIG. 6 is a graph showing the growth rate and feed intake rate of the flounder of Experimental Example 5 for confirming the effect of the addition of the feed additive for accelerating weight gain of the present invention on the flounder rearing.
- FIG. 7 is a graph showing the conversion efficiency and protein efficiency of flounder in Experimental Example 5 for confirming the effect of the addition of the feed additive for promoting weight gain of the present invention on the flounder rearing.
- FIG. 8 is a graph showing the survival rate of the flounder of Experimental Example 5 in order to confirm the effect of the feed additive supplementation promoting weight gain of the present invention on the flounder rearing.
- the feed additive for promoting weight gain of the present invention is characterized in that the content of the fatty acid having 14 or less carbon atoms in the constituent fatty acid is 10 to 90% by weight, the content of the fatty acid having 14 or less carbon atoms bonded to the 1,3-position is 10 to 80% It contains 50% by weight or more of diglycerides.
- the feed additive for promoting weight gain comprises a large amount of diglycerides containing a fatty acid having a carbon number of 14 or less as a constituent fatty acid.
- the triglyceride (triglyceride) used as a fat source in feed is decomposed into 2-monoglyceride and free fatty acid by the fat-degrading enzyme of livestock, and 2-monoglyceride is re-synthesized again as triglyceride, It accumulates in my province.
- 1,3-diglycerides are decomposed into glycerol by lipase, so they are not converted into 2-monoglycerides, which are re-synthesized with triglycerides.
- the degraded free fatty acids are transported to the liver, . Therefore, the fat composition for feed of the present invention can be used as an energy source without being accumulated at the time of feeding as a fat source of livestock, thereby improving productivity of livestock.
- diglycerides constitute diglycerides of fatty acids of 14 or less by the body is decomposed into free fatty acids and then easily absorbed in the small intestine cells into the context of free fatty acids into the liver and quickly metabolized into the energy source.
- the fatty acids having 16 or more carbon atoms are reesterified by the intestinal mucosal cells to become triglycerides, and they become lipoproteins called chiomicrons together with proteins and are transported throughout the body and accumulated in body fat.
- fatty acids are rapidly metabolized because they do not require the carnitine required to enter the mitochondria for ⁇ -oxidation of fatty acids.
- the feed additive for promoting weight gain of the present invention is characterized in that the weight ratio of the fatty acid having the carbon number of 14 or less to the fatty acid having the carbon number of 16 or more among the constituent fatty acids of the diglyceride is 4 to 7 and the fatty acid having the carbon number of 14 or less And the content of fatty acids of 16 or more carbon atoms accumulated in body fat was re-synthesized as neutral fatty acid.
- the diglycerides are mainly composed of 1,3-diglycerides.
- the content of 1,3-diglyceride is 40% by weight or more.
- the 1,2-diglycerides and 2,3-diglycerides are degraded by lipase, a lipase which is an intramolecular lipase, and 2-monoglyceride and one fatty acid are decomposed, and they are used as an energy source or not as an energy source
- Fatty acids are again used to synthesize glycerides or triglycerides and accumulate in fat in subcutaneous tissues.
- Such diglycerides are contained in an amount of 50 to 70% by weight in the feed additive for promoting weight gain of the present invention. If the content is less than the above range, the content of triglyceride, which is a cause of accumulation of livestock fat relatively, is increased. On the other hand, if the content exceeds the above range, additional purification process is required, which is not economical. There is a problem that the content of necessary triglyceride is lowered and the growth is lowered or the meat quality is lowered. Therefore, it is suitably used within the above range.
- the constituent fatty acids of diglycerides are preferably 70 to 90% by weight of a fatty acid having a carbon number of 14 or less and 10 to 30% by weight of a fatty acid having a carbon number of 16 or more in terms of physiological effect to be used as a quick energy source.
- the content of the fatty acids having 14 or less carbon atoms in the fatty acids bound to positions 1 and 3 decomposed into lipases by lipases in the livestock is preferably 60 to 80% by weight .
- fatty acids having 14 or less carbon atoms there can be known kinds of fatty acids having 14 or less carbon atoms, and the kind thereof is not particularly limited in the present invention.
- one selected from the group consisting of caprylic acid, pelargonic acid, capric acid, undecanoic acid, lauric acid, myristic acid, and mixtures thereof is used.
- one kind selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, and mixtures thereof is more preferable.
- the fatty acid having 16 or more carbon atoms is preferably one selected from the group consisting of palmitic acid, oleic acid, linoleic acid, stearic acid, and mixtures thereof in terms of oxidation stability and fatty acid digestion and absorption of the oil composition, and palmitic acid, stearic acid, , And mixtures thereof.
- the feed additive for promoting weight gain of the present invention may be added to the formulated feed as a substitute for the fat source in the formulated feed or in the form of an additive.
- the feed composition for livestock according to the present invention may contain diglyceride in an amount of 0.005 to 2.5% by weight based on the total weight of the compound feed including the feed additive for promoting weight gain.
- the feed additive for promoting weight gain is mixed with a feed 0.01 to 5.0% by weight, preferably 0.01 to 3.0% by weight, based on the total weight. If the content of the feed additive for accelerating weight gain contained in the livestock feed according to the present invention is less than the above range, it is difficult to expect the use effect thereof. On the other hand, if the content exceeds the above range, the nutritional status of the livestock becomes unbalanced .
- the feed composition for livestock of the present invention can be substituted with 40 to 60% by weight of the fat source in the compound feed by the feed additive for promoting weight gain.
- the fat source in the formulated feed there is no quality variation compared with the conventional fat source, fish oil, and soybean oil, and the cost is low, which is economical advantage.
- the feed composition for livestock can be constituted by adding the fat composition of the present invention to any compounded feed which is known or commercially available in the art. Therefore, the composition and the production method are not particularly limited in the present invention.
- Cattle are pigs, chickens, ducks, quails, geese, pheasants, turkeys, cows, cows, horses, donkeys, sheep, goats, dogs, cats, rabbits, various fishes and shrimp.
- the feed composition according to the present invention may contain various antibiotics, probiotics, enzymes, organic acids, flavors, sweeteners, antioxidants, and the like in order to improve the health condition of an animal or to obtain a positive effect for productivity improvement and production of high quality livestock products, And other functional materials.
- the feed composition according to the present invention can be fed for a normal period of time to become an appropriate weight depending on the purpose of raising livestock.
- the present invention provides a method for raising livestock, comprising feeding the feed composition for livestock to livestock.
- the feed composition for livestock according to the present invention When used for feeding to livestock, the daily gain and the feed efficiency are increased compared with the conventional feeds, and the effect of improving the production amount can be obtained. Especially, the amount of triglyceride in the livestock blood decreases, .
- Example 1 Preparation of a fat composition for feed additive
- the mixed fatty acid (400 g) and glycerol (92 g) were added with NaOH as an alkali catalyst at 250 ⁇ and esterification was carried out for 2 hours to obtain an ester compound having an acid value of 1 or less to obtain a glyceride composition according to the present invention.
- the pyrolysis and glyceride analyzes of the prepared glyceride compositions were analyzed by the methods described below and are shown in Tables 1 and 2 below.
- the sample was injected at a concentration of 25 g / l under the conditions of HP-INNOWAX (Agilent, USA), carrier gas helium (2.1 ml / min), oven temperature of 150 to 260 ⁇ and flame ionization detector (FID) Respectively.
- the column used was ChromSpher Lipids, 5 ⁇ m, 25 cm [varian, USA], mobile phase solvent was n-hexane containing 0.5% acetonitrile, 1 mg / ml (chloroform solvent) and analyzed with an evaporative scattering light detector (ELSD) at a flow rate of 2.3 ml / min.
- ELSD evaporative scattering light detector
- Test diets were fed with corn-soybean meal based on NRC (2012) requirements, and water was freely fed using an automatic water dispenser.
- Body weight gain was measured at the start, at 2 weeks and at the end (6 weeks) by treatments.
- the daily dietary intake was calculated by subtracting the remaining amount from the feed diets at the time of body weight measurement, and the feed efficiency was calculated by dividing the dietary body weight by the feed intake. The results are shown in Table 3.
- Nutrient digestibility was obtained by adding 0.2% of chromium oxide (Cr 2 O 3 ) as a labeling substance at the end of 2 weeks and at the end of 6 weeks.
- the samples were dried in a dryer at 60 ° C for 72 hours, and then pulverized with a Willey mill. Cr mixed with the general components of the feed and labeling was analyzed according to the method of AOAC (2000). The results are shown in Table 4.
- Serum biochemical tests were obtained by collecting 5 mL of blood using a Vacuum tube (Becton Dickinson Vacutainer Systems, Franklin Lakes, NJ) and then centrifuging at 3,000 rpm for 15 minutes at 4 ° C in an enzymatic colorimetric method (Allain et al Total cholesterol and HDL cholesterol concentrations were measured by a biochemical analyzer (HITACHI 747, Japan) in response to a test reagent (Cholesterol Kit No. 352, Sigma Chemical, St. Louis, Mo., USA) LDL cholesterol concentration was measured by Naoyuki and Yoshiharu (1995). The results are shown in Table 5.
- the body weight gain of Phase 1 was significantly higher in the experimental group 2 and the experimental group 3 than in the negative control group and the control group.
- the body weight gain of Phase 2 was significantly higher in the experimental group 1, the experimental group 2, the experimental group 3, the comparative group 2 and the comparative group 3 than the negative control group.
- the body weight gain of the experimental group 3 was significantly higher than that of the control group 1 and the control group 1, and the feed efficiency of experimental group 1 and experimental group 3 was significantly higher than that of control group.
- the number of 1 day old ROSS 308 (female, male) was 510, and the weight of the test was 41 ⁇ 0.17g.
- the treatment of the animals in each group was as follows: 6 replicates per treatment, 17 replicates per replicate.
- test diets were fed with corn - soybean meal based on NRC (1994) requirements.
- ROSS 308 chicks were raised in a three - stage cage, and the position of the treatments was adjusted, and the feed and water were free - veganized.
- Body weight was measured by treatment at initiation, 3 weeks, 1 week and 5 weeks.
- the feed intake was calculated by subtracting the remaining amount from the feed amount during body weight measurement.
- the feed conversion ratio was calculated by dividing the feed intake by the body weight gain.
- the treatment groups were randomly selected and slaughtered by the tibial resection method, and the weight of the liver, spleen, F sac, abdominal fat, chest muscle and proximal portion was measured and calculated as the ratio to the living body weight.
- the pH was measured using a pH meter (77P, Istek, Korea) and the meat color was measured twice per each chest meat sample using a colorimeter (Model CR-410, Minolta Co., Japan).
- the drip loss was measured by measuring the amount of loss after 1 day, 3 days, 5 days and 7 days after storing the samples in a constant shape of 4 cm thickness and storing them in a polyethylene bag for 7 days in a refrigerator at 4 °C.
- Blood samples were collected from 6 rats per each treatment and analyzed by collecting 2 mL of blood using a K3EDTA Vacuum tube (Becton Dickson Vacutainer Systems, Franklin Lakes, NJ) at Jugular at the end of the study (5 weeks) FFA (free fatty acid) was investigated using an automatic blood analyzer (ADVID 120, Bayer, USA).
- the serum biochemical test was performed by collecting 5 ml of blood using a Vacuum tube (Becton Dickinson Vacutainer Systems, Franklin Lakes, NJ) in the jugular vein at the end (5 weeks) and centrifuging at 3,000 rpm for 15 minutes at 4 ° C. Were used for analysis.
- the contents of Protein, BUN, Creatinine, Triglyceride and Glucose in the separated serum were analyzed by nephelometer method using a nephelometer (Behring, Germany) analyzer.
- the broiler gas production was measured at the end of the test (5 weeks) in order to measure the generation of ammonia, hydrogen sulfide and total mercaptan.
- Ammonia, hydrogen sulfide and total mercaptan were weighed and stored at room temperature for 5 days using a Gastec (Model GV-100, Gastec, Japan) after placing in a plastic container with a volume of 2,600 mL 5 days.
- Nutrient digestibility was determined by adding 0.2% of chromium oxide (Cr 2 O 3 ) as a labeling substance at the end (5 weeks) and collecting the powder after 7 days of feeding. The samples were dried in a dryer at 60 ° C for 72 hours, and then pulverized with a Willey mill. Cr mixed with the general components of the feed and labeling was analyzed according to the method of AOAC (2000).
- Cr 2 O 3 chromium oxide
- Experiment 1 Experiment 2
- Experiment group 3 1-7 days BWG, g 189 187 191 192 193 FI, g 216 213 215 215 216 FCR 1.144 1.142 1.128 1.124 1.116 7-21 days BWG, g 574 557 591 600 600 FI, g 935 953 938 934 928 FCR 1.633 1.713 1.591 1.558 1.546 21-35 days BWG, g 906 893 917 918 963 FI, g 1535 1537 1542 1539 1540 FCR 1.699 1.723 1.686 1.678 1.608 Whole period BWG, g 1668 1638 1699 1710 1756 FI, g 2686 2704 2695 2689 2683 FCR 1.612 1.652 1.588 1.573 1.531
- Experiment 1 Experiment 2
- Experiment group 3 Protein, g / dL 3.37 3.18 3.12 3.28 3.47 BUN, mg / dL 2.40 2.62 2.62 2.55 2.65 Creatinine, mg / dL 0.113 0.108 0.122 0.108 0.132 Triglyceride, mg / dL 48 45 43 41 43 FFA, uEq / L 449 443 434 443 460 Glucose, mg / dL 178 175 173 172 176
- Example 1 The oil composition of Example 1 was fed to Ross 308 1 day old 600 counts (4 treatments x 30 repeats per 5 replicates). At this time, the commercially available broiler feedstuffs were fed with the contents of 0.1, 0.2 and 0.4 wt% for 36 days. (ME, 3080 kcal / kg; CP, 20.5%) were fed for 20 days and the second feed (ME, 3100 kcal / kg; CP, 19.5%) were fed for 16 days.
- ME 3080 kcal / kg; CP, 20.5%
- the treatment of the animals in each group was as follows: (% is% by weight)
- the free fatty acid concentration increased with the addition of the fat composition of Example 1, and the blood triglyceride concentration decreased linearly in contrast.
- the average weight of the flounder in each tank was 13.4 g. Feeds were supplied at 8:00 PM and 18:00 PM. The water temperature of the water tank was 15 to 21 ° C, and it was bred for 12 weeks. At this time, the animal feed of each group is shown in Table 15 below. Specific growth rate (%), feed intake, feed conversion ratio, and protein efficiency ration were calculated as follows to investigate the growth rate and feed efficiency: The results are shown in Figs. 1 to 4
- Specific growth rate (%) (Ln final weight (g) - Ln initial weight (g)) / experimental days ⁇ 100.
- Feed intake (g / fish) dry feed fed / fish
- Feed conversion ratio dry feed / wet weight gain
- Protein efficiency ratio wet weight gain / total protein intake
- FIG. 1 is a graph showing the body weight and body weight gain of the flounder at the end of the experiment
- FIG. 2 is a graph showing the growth rate and feed intake rate of the flounder
- FIG. 3 is a graph showing the feed conversion and protein utilization efficiency
- FIG. 5 is a graph showing the body weight and body weight gain of the flounder at the end of the experiment
- FIG. 6 is a graph showing the growth rate and feed intake rate of the flounder
- FIG. 7 is a graph showing the feed conversion and protein utilization efficiency
- FIG. 8 is a graph showing the survival rate of the flounder.
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Abstract
Description
구분 | 구분(중량%) | ||
유리 지방산 | 0.6 | ||
글리세라이드 조성 | 모노글리세라이드 | 24.5 | |
디글리세라이드 | 1,3-DG | 40.5 | |
1,2-DG | 13.5 | ||
트리글리세라이드 | 20.9 |
디글리세라이드 구성 지방산 조성 | 실시예 1 | ||
1,3 | 1,2 | 전체 | |
C8:0(카프릴산) | 8.2 | 10.2 | 8.7 |
C10:0(카프르산) | 7.8 | 9.8 | 8.3 |
C12:0(라우르산) | 47.0 | 58.2 | 49.8 |
C14:0(미리스트산) | 16.4 | 13.2 | 16.4 |
C16:0(팔미트산) | 9.6 | 5.6 | 8.8 |
C18:0(스테아르산) | 11.0 | 3.0 | 8.0 |
탄소수 14 이하의 지방산/탄소수 16 이상의 지방산 | 3.9 | 10.6 | 5.0 |
구분 | 양성대조군 | 실험군 1 | 실험군 2 | 실험군 3 | 음성 대조군 | 비교군 1 | 비교군 2 | 비교군 3 |
Phase 1(1~14일) | ||||||||
일당증체량(ADG, g) | 366 | 371 | 383 | 390 | 333 | 343 | 362 | 373 |
사료섭취량(ADFI, g) | 424 | 421 | 428 | 430 | 397 | 387 | 401 | 418 |
G/F | 0.863 | 0.881 | 0.895 | 0.907 | 0.839 | 0.886 | 0.903 | 0.892 |
Phase 2(14~42일) | ||||||||
일당증체량(ADG, g) | 521 | 537 | 543 | 553 | 492 | 519 | 537 | 541 |
사료섭취량(ADFI, g) | 826 | 817 | 838 | 847 | 821 | 832 | 585 | 841 |
G/F | 0.631 | 0.657 | 0.648 | 0.653 | 0.602 | 0.624 | 0.626 | 0.643 |
(1~42일) | ||||||||
일당증체량(ADG, g) | 469 | 482 | 490 | 499 | 439 | 460 | 479 | 485 |
사료섭취량(ADFI, g) | 692 | 685 | 701 | 708 | 680 | 683 | 705 | 700 |
G/F | 0.678 | 0.704 | 0.699 | 0.705 | 0.649 | 0.673 | 0.679 | 0.693 |
구분(%) | 양성대조군 | 실험군 1 | 실험군 2 | 실험군 3 | 음성 대조군 | 비교군 1 | 비교군 2 | 비교군 3 |
2 주 | ||||||||
건물 | 79.60 | 80.04 | 80.68 | 79.54 | 80.23 | 79.96 | 79.27 | 80.10 |
질소 | 75.56 | 73.37 | 74.08 | 75.27 | 75.67 | 73.89 | 74.36 | 73.98 |
에너지 소화율 | 79.75 | 77.45 | 79.38 | 77.97 | 77.93 | 79.53 | 78.83 | 78.02 |
6 주 | ||||||||
건물 | 77.74 | 77.68 | 77.34 | 77.03 | 76.88 | 76.94 | 76.79 | 76.35 |
질소 | 73.00 | 72.68 | 73.23 | 73.50 | 73.40 | 72.88 | 73.03 | 72.60 |
에너지 소화율 | 76.61 | 75.70 | 75.94 | 76.05 | 76.01 | 76.40 | 76.02 | 75.98 |
구분 | 양성대조군 | 실험군 1 | 실험군 2 | 실험군 3 | 음성 대조군 | 비교군 1 | 비교군 2 | 비교군 3 |
WBC, 103/l | 13.46 | 15.30 | 12.73 | 15.34 | 15.87 | 14.55 | 14.61 | 15.42 |
RBC, 106/l | 5.22 | 5.30 | 5.40 | 5.75 | 5.61 | 5.77 | 5.32 | 6.08 |
림프구, % | 48.7 | 50.8 | 48.1 | 51.9 | 48.6 | 53.7 | 49.1 | 51.5 |
HDL 콜레스테롤, mg/dL | 35 | 35 | 38 | 38 | 32 | 34 | 33 | 36 |
LDL 콜레스테롤, mg/dL | 48 | 56 | 58 | 58 | 55 | 59 | 55 | 55 |
총 콜레스테롤, mg/dL | 96 | 101 | 108 | 108 | 94 | 96 | 107 | 103 |
구분( log10cfu/g) | 양성대조군 | 실험군 1 | 실험군 2 | 실험군 3 | 음성 대조군 | 비교군 1 | 비교군 2 | 비교군 3 |
Lactobacillus | 7.36 | 7.40 | 7.51 | 7.53 | 7.59 | 7.42 | 7.23 | 7.49 |
E. coli | 5.18 | 4.84 | 5.05 | 4.97 | 5.18 | 5.01 | 4.82 | 4.77 |
구분(ppm) | 양성대조군 | 실험군 1 | 실험군 2 | 실험군 3 | 음성 대조군 | 비교군 1 | 비교군 2 | 비교군 3 |
암모니아 | 11.48 | 12.10 | 11.15 | 13.10 | 10.23 | 9.58 | 9.33 | 9.68 |
황화수소 | 9.7 | 9.8 | 9.4 | 10.0 | 9.4 | 8.9 | 8.4 | 8.9 |
총 메캅탄 | 7.8 | 8.0 | 7.7 | 8.7 | 7.7 | 7.5 | 7.4 | 7.7 |
구분 | 양성대조군 | 실험군 1 | 실험군 2 | 실험군 3 | 음성 대조군 | 비교군 1 | 비교군 2 | 비교군 3 |
2 주 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 |
6 주 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 |
구분 | 양성대조군 | 음성대조군 | 실험군 | ||
실험군1 | 실험군2 | 실험군3 | |||
1-7 일 | |||||
BWG, g | 189 | 187 | 191 | 192 | 193 |
FI, g | 216 | 213 | 215 | 215 | 216 |
FCR | 1.144 | 1.142 | 1.128 | 1.124 | 1.116 |
7-21 일 | |||||
BWG, g | 574 | 557 | 591 | 600 | 600 |
FI, g | 935 | 953 | 938 | 934 | 928 |
FCR | 1.633 | 1.713 | 1.591 | 1.558 | 1.546 |
21-35 일 | |||||
BWG, g | 906 | 893 | 917 | 918 | 963 |
FI, g | 1535 | 1537 | 1542 | 1539 | 1540 |
FCR | 1.699 | 1.723 | 1.686 | 1.678 | 1.608 |
전체 기간 | |||||
BWG, g | 1668 | 1638 | 1699 | 1710 | 1756 |
FI, g | 2686 | 2704 | 2695 | 2689 | 2683 |
FCR | 1.612 | 1.652 | 1.588 | 1.573 | 1.531 |
Items | 양성 대조군 | 음성 대조군 | 실험군 | ||
실험군 1 | 실험군 2 | 실험군 3 | |||
pH | 5.41 | 5.41 | 5.41 | 5.44 | 5.40 |
가슴육 육색(Breast muscle color) | |||||
Lightness (L*) | 57.14 | 57.30 | 57.43 | 57.06 | 57.38 |
Redness (a*) | 13.77 | 13.23 | 13.35 | 13.13 | 13.36 |
Yellowness (b*) | 12.27 | 12.39 | 12.22 | 12.42 | 23.44 |
저장감량, % | |||||
1d | 2.60 | 2.76 | 1.89 | 1.70 | 1.75 |
3d | 5.43 | 5.43 | 5.21 | 5.05 | 5.18 |
5d | 8.99 | 9.93 | 8.76 | 8.60 | 8.27 |
7d | 14.64 | 14.46 | 13.04 | 12.98 | 12.43 |
상대적 장기 중량, % | |||||
간 | 2.63 | 2.64 | 2.64 | 2.67 | 2.65 |
비장 | 0.13 | 0.13 | 0.13 | 0.13 | 0.12 |
파브리시우스 낭(Bursa of Fabricius) | 0.20 | 0.19 | 0.19 | 0.20 | 0.19 |
가슴육 | 9.49 | 9.35 | 9.50 | 9.84 | 9.78 |
구분 | 양성 대조군 | 음성 대조군 | 실험군 | ||
실험군 1 | 실험군 2 | 실험군 3 | |||
단백질, g/dL | 3.37 | 3.18 | 3.12 | 3.28 | 3.47 |
BUN, mg/dL | 2.40 | 2.62 | 2.62 | 2.55 | 2.65 |
Creatinine, mg/dL | 0.113 | 0.108 | 0.122 | 0.108 | 0.132 |
Triglyceride, mg/dL | 48 | 45 | 43 | 41 | 43 |
FFA, uEq/L | 449 | 443 | 434 | 443 | 460 |
Glucose, mg/dL | 178 | 175 | 173 | 172 | 176 |
구분(ppm) | 양성대조군 | 음성 대조군 | 실험군 | ||
실험군 1 | 실험군 2 | 실험군 3 | |||
NH3 | 5.33 | 5.50 | 5.17 | 5.50 | 5.33 |
R.SH | 2.42 | 2.08 | 2.25 | 2.25 | 2.08 |
H2S | 1.75 | 1.58 | 1.58 | 1.67 | 1.25 |
구분(%) | 양성 대조군 | 음성 대조군 | 실험군 | ||
실험군 1 | 실험군 2 | 실험군 3 | |||
건물 소화율 | 72.56 | 71.37 | 73.17 | 73.55 | 73.75 |
질소 소화율 | 66.65 | 65.69 | 67.78 | 68.29 | 68.73 |
에너지 소화율 | 74.32 | 73.43 | 75.18 | 75.56 | 75.98 |
구분 | 양성 대조군 | 실험군 1 | 실험군 2 | 실험군 3 |
초기 체중(g) | 41.5 | 41.7 | 41.6 | 41.7 |
최종 체중(g) | 2205.4 | 2218.4 | 2293.1 | 2254.5 |
증체량(g/일) | ||||
1~20일 | 43.8 | 44.3 | 46.1 | 46.8 |
21~36일 | 88.8 | 89.1 | 91.6 | 87.9 |
1~36일 | 61.8 | 62.2 | 64.3 | 63.2 |
FI g/일/마리 | ||||
1~20일 | 68.1 | 66.8 | 67.9 | 69.4 |
21~36일 | 173.9 | 176.9 | 185.1 | 175.4 |
1~36일 | 110.4 | 110.8 | 114.8 | 111.8 |
사료요구율(FCR) | ||||
1~20일 | 1.56 | 1.51 | 1.47 | 1.48 |
21~36일 | 1.96 | 1.99 | 2.02 | 1.99 |
1~306 | 1.79 | 1.78 | 1.79 | 1.77 |
지방산(μEq/L) | 317.7 | 211.50 | 387.7 | 411.6 |
중성지방(mg/dL) | 92.60 | 99.20 | 56.60 | 63.00 |
성분 (중량%) | 대조군 | 실험군 |
어분 | 55.0 | 55.0 |
대두박 | 6.0 | 6.0 |
옥수수 글루텐 박 | 4.0 | 4.0 |
밀가루 | 26.5 | 26.5 |
혼합 미네랄 | 1.0 | 1.0 |
혼합 비타민 | 1.0 | 1.0 |
콜린클로라이드 | 0.5 | 0.5 |
어유 | 6.0 | 3.0 |
실시예 1의 유지 조성물 | - | 3.0 |
성분 (중량%) | 대조군 | 실험군 |
어분 | 55.0 | 55.0 |
대두박 | 6.0 | 6.0 |
옥수수 글루텐 박 | 4.0 | 4.0 |
밀가루 | 26.5 | 26.5 |
혼합 미네랄 | 1.0 | 1.0 |
혼합 비타민 | 1.0 | 1.0 |
콜린클로라이드 | 0.5 | 0.5 |
어유 | 6.0 | 4.0 |
전분 | - | 1.5 |
실시예 1의 유지 조성물 | - | 0.5 |
Claims (11)
- 전체 100 중량%가 되도록 디글리세라이드 50 내지 70 중량%와,트리글리세라이드, 모노글리세라이드, 유리 지방산 또는 이들의 혼합물 잔부를 포함하는 유지 조성물이고,상기 디글리세라이드 중 1,3-디글리세라이드의 함량은 40 중량% 이상이며,상기 디글리세라이드의 구성 지방산 중 탄소수 14 이하의 지방산의 함량이 70 내지 90 중량%, 탄소수 16 이상의 지방산의 함량은 10 내지 30 중량%이며,상기 디글리세라이드의 구성 지방산 중 1,3번 위치에 결합된 지방산에 대한 탄소수 14 이하의 지방산의 함량이 60 내지 80 중량%인 체중 증가 촉진용 사료 첨가제.
- 제1항에 있어서, 상기 구성지방산 중 탄소수 14 이하의 지방산/탄소수 16 이상의 지방산의 중량비가 4 내지 7인 것인 체중 증가 촉진용 사료 첨가제.
- 제1항에 있어서, 상기 탄소수 14 이하의 지방산은카프릴산, 펠라르곤산, 카프르산, 운데카노산, 라우르산, 미리스트산 및 이들의 혼합물로 이루어진 군에서 선택되는 것인 체중 증가 촉진용 사료 첨가제.
- 제1항에 있어서, 상기 탄소수 16 이상의 지방산은팔미트산, 올레산, 리놀레산, 스테아르산 및 이들의 혼합물로 이루어진 군에서 선택되는 것인 체중 증가 촉진용 사료 첨가제.
- 제1항 내지 제4항 중 어느 한 항에 따른 체중 증가 촉진용 사료 첨가제 및 배합사료를 포함하는 가축용 사료 조성물.
- 제5항에 있어서, 상기 가축용 사료 조성물은 돼지, 닭, 오리, 메추라기, 거위, 꿩, 칠면조, 소, 젖소, 말, 당나귀, 양, 염소, 개, 고양이, 토끼, 양식 어류 또는 새우 사육용인 것인 가축용 사료 조성물.
- 제5항에 있어서, 상기 체중 증가 촉진용 사료 첨가제의 함량은 배합사료 총중량을 기준으로 0.01 내지 5.0 중량%인 가축용 사료 조성물.
- 제5항의 가축용 사료 조성물을 급여하는 것을 특징으로 하는 가축 사육방법.
- 제1항 내지 제4항 중 어느 한 항에 따른 체중 증가 촉진용 사료 첨가제로 배합사료 내 지방원의 40 내지 60 중량%로 대체한 가축용 사료 조성물.
- 제9항에 있어서, 상기 가축용 사료 조성물은 돼지, 닭, 오리, 메추라기, 거위, 꿩, 칠면조, 소, 젖소, 말, 당나귀, 양, 염소, 개, 고양이, 토끼, 양식 어류 또는 새우 사육용인 것인 가축용 사료 조성물.
- 제10항의 가축용 사료 조성물을 급여하는 것을 특징으로 하는 가축 사육방법.
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JP2018515969A JP6491397B2 (ja) | 2015-06-05 | 2017-03-22 | 体重増加促進用飼料添加剤、家畜用飼料組成物および家畜飼育方法 |
MX2018006543A MX2018006543A (es) | 2015-06-05 | 2017-03-22 | Aditivo alimenticio para promover el aumento de peso, composicion alimenticia para ganado y metodo de cria de ganado. |
MYPI2018700873A MY189441A (en) | 2015-06-05 | 2017-03-22 | Weight gain promoting feed additive, livestock feed composition and livestock breeding method |
BR112018007258-3A BR112018007258A2 (pt) | 2015-06-05 | 2017-03-22 | aditivo de ração promotor de ganho de peso, composição de ração para animais de criação e métodos para cultivar animais de criação |
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EP17806875.5A EP3363296A4 (en) | 2015-06-05 | 2017-03-22 | ADDITIVE FEED FOR PROMOTING IMPROVEMENT IN LIVESTOCK, LIVESTOCK COMPOSITION AND LIVESTOCK PROCESSING |
US15/764,953 US20190075824A1 (en) | 2016-06-01 | 2017-03-22 | Weight gain promoting feed additive, livestock feed composition and livestock breeding method |
CN201780004022.7A CN108471784A (zh) | 2015-06-05 | 2017-03-22 | 促增重饲料添加剂、牲畜饲料组合物和牲畜养殖方法 |
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KR102149081B1 (ko) * | 2017-05-16 | 2020-08-28 | 윤관식 | 동물용 사료 첨가제, 이를 포함하는 동물용 사료 조성물 및 동물 사육 방법 |
CN107691362A (zh) * | 2017-10-31 | 2018-02-16 | 北京泽牧久远生物科技研究院 | 一种肉驴育肥预混料及其饲喂方法 |
CN110959761A (zh) * | 2019-12-23 | 2020-04-07 | 榆林学院 | 一种羊饲料添加剂及其制备方法 |
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CA2924979A1 (en) * | 2013-10-09 | 2015-04-16 | Nutrition Sciences N.V. | Composition of medium-chain fatty acids and feed supplemented with composition |
CN105724781A (zh) * | 2016-02-23 | 2016-07-06 | 广州英赛特生物技术有限公司 | 一种饲用组合物及其在制备动物饲料添加剂中的应用 |
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2016
- 2016-02-01 KR KR1020160012323A patent/KR101719598B1/ko active IP Right Grant
- 2016-06-01 WO PCT/KR2016/005786 patent/WO2016195369A1/ko active Application Filing
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2017
- 2017-03-22 CN CN201780004022.7A patent/CN108471784A/zh active Pending
- 2017-03-22 RU RU2018112446A patent/RU2682389C1/ru active
- 2017-03-22 CA CA3002794A patent/CA3002794C/en active Active
- 2017-03-22 MX MX2018006543A patent/MX2018006543A/es unknown
- 2017-03-22 BR BR112018007258-3A patent/BR112018007258A2/pt not_active Application Discontinuation
- 2017-03-22 MY MYPI2018700873A patent/MY189441A/en unknown
- 2017-03-22 EP EP17806875.5A patent/EP3363296A4/en not_active Withdrawn
- 2017-03-22 JP JP2018515969A patent/JP6491397B2/ja active Active
- 2017-03-22 WO PCT/KR2017/003077 patent/WO2017209382A1/ko active Application Filing
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2018
- 2018-03-22 CO CONC2018/0003076A patent/CO2018003076A2/es unknown
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JPH0556755A (ja) * | 1991-06-17 | 1993-03-09 | Kao Corp | 家畜用飼料添加物及び家畜用飼料 |
US5859270A (en) * | 1996-03-13 | 1999-01-12 | Cargill, Incorporated | Method for preparation of purified monoglycerides; and, products |
KR20040036941A (ko) * | 2001-09-13 | 2004-05-03 | 가오가부시끼가이샤 | 유지 조성물 |
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KR20160143488A (ko) * | 2015-06-05 | 2016-12-14 | 윤관식 | 사료용 유지 조성물, 이를 이용한 성장 촉진용 사료 첨가제, 가축용 사료 조성물 및 가축 사육 방법 |
Non-Patent Citations (1)
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See also references of EP3363296A4 * |
Also Published As
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CA3002794C (en) | 2020-03-31 |
BR112018007258A2 (pt) | 2018-10-30 |
KR20160143488A (ko) | 2016-12-14 |
KR101719598B1 (ko) | 2017-03-24 |
RU2682389C1 (ru) | 2019-03-19 |
CA3002794A1 (en) | 2017-12-07 |
EP3363296A1 (en) | 2018-08-22 |
EP3363296A4 (en) | 2019-06-19 |
MX2018006543A (es) | 2018-08-15 |
JP6491397B2 (ja) | 2019-03-27 |
WO2016195369A1 (ko) | 2016-12-08 |
CO2018003076A2 (es) | 2018-06-12 |
JP2018529349A (ja) | 2018-10-11 |
CN108471784A (zh) | 2018-08-31 |
PH12018501152A1 (en) | 2019-01-21 |
MY189441A (en) | 2022-02-12 |
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