WO2017141696A1 - 自動分析装置 - Google Patents
自動分析装置 Download PDFInfo
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- WO2017141696A1 WO2017141696A1 PCT/JP2017/003480 JP2017003480W WO2017141696A1 WO 2017141696 A1 WO2017141696 A1 WO 2017141696A1 JP 2017003480 W JP2017003480 W JP 2017003480W WO 2017141696 A1 WO2017141696 A1 WO 2017141696A1
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- reagent
- lid
- piercing
- needle
- reagent bottle
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0403—Sample carriers with closing or sealing means
- G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0406—Individual bottles or tubes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0446—Combinations of the above
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Definitions
- the present invention relates to an automatic analyzer for analyzing a liquid sample such as a reagent, blood or urine, and more particularly to an automatic analyzer for automatically opening a reagent bottle.
- the piercer in the invention aimed at accurately inserting the suction tube into the position of the central axis of the sample container, the piercer is formed so that the tip can penetrate the sealing lid of the long vial,
- the piercer moving unit has a function of moving the piercer in the vertical direction, and has a horizontal arm that fixes and holds the piercer, a screw shaft that penetrates the horizontal arm in the vertical direction, and a nut that is screwed to the screw shaft.
- Reagents used in automatic analyzers are usually installed by the operator after opening the lid of the reagent bottle.
- the reagent lid is slightly cut with a needle. It is known to suck a reagent by inserting a reagent probe into the hole.
- the reagent bottle is cut before the reagent probe is inserted, and the reagent probe is inserted while expanding the notch hole with the reagent probe when the reagent is aspirated. After the reagent probe comes out of the lid, the notch is closed again. It has a structure.
- the structure in which the lid is closed as described above has advantages such as reducing the time that the reagent in the reagent bottle is exposed to the outside air, ensuring the stability of the reagent, and increasing the filling amount of the reagent bottle. is there.
- each mechanism is operating at a high speed, and the reagent probe is also operating at a higher speed than before.
- the reagent probe is inserted at a high speed into the hole with a slight notch in the lid of the reagent bottle, it is important to always stably drill the center of the lid using a needle. It is.
- the center of the lid is a mortar-shaped apex. If the position of the drilling operation performed by the needle with respect to the lid is shifted, in the worst case, the tip of the reagent probe comes into contact with the mortar-shaped apex of the lid that is not cut when the reagent probe is lowered in the reagent suction operation. There is a risk of bending the reagent probe.
- the present invention has been made to solve the above-described problem, and an automatic analyzer capable of accurately opening the center of a reagent bottle lid even when the center of the needle and the center axis of the lid are displaced. It is intended to provide.
- the present invention includes a plurality of means for solving the above-described problems. For example, a sample and a reagent are dispensed into a plurality of reaction containers and reacted, and the reacted liquid is measured.
- a reagent disk for storing a reagent bottle containing the reagent, and a needle for making a hole in a lid of the reagent bottle that is inserted into the automatic analyzer and carried into the reagent disk A reagent bottle lid opening portion having a centering mechanism for adjusting the position of the needle relative to the lid so that the needle is stuck in the center of the lid. To do.
- FIG. 1 is a perspective view of the automatic analyzer according to the present embodiment.
- an automatic analyzer is a device for dispensing a sample and a reagent in a plurality of reaction vessels 2 and reacting them, and measuring the reacted liquid.
- Reaction container 2 is arranged on the circumference of reaction disk 1.
- a sample transport mechanism 17 for moving a rack 16 on which a sample container 15 is placed is installed near the reaction disk 1.
- a sample dispensing mechanism 11 that can rotate and move up and down is installed, and includes a sample probe 11a.
- a sample syringe 19 is connected to the sample probe 11a. The sample probe 11a moves while drawing an arc around the rotation axis, and dispenses the sample from the sample container 15 to the reaction container 2.
- reagent disk 9 a plurality of reagent bottles 10 can be placed on the circumference.
- the reagent disk 9 is kept cold and is covered with a cover provided with a suction port 111 (see FIG. 2).
- reagent dispensing mechanisms 7 and 8 that can be rotated and moved up and down are installed, and reagent probes 7a and 8a are provided, respectively.
- a reagent syringe 18 is connected to the reagent probes 7a and 8a.
- the reagent probes 7 a and 8 a move while drawing an arc around the rotation axis, access the reagent disk 9 from the suction port 111, and dispense the reagent from the reagent bottle 10 to the reaction container 2.
- a cleaning mechanism 3 Around the reaction disk 1, a cleaning mechanism 3, a light source 4a, a spectrophotometer 4, and stirring mechanisms 5 and 6 are further arranged.
- a cleaning pump 20 is connected to the cleaning mechanism 3.
- Washing tanks 32, 33, 13, 30, and 31 are installed on the operation ranges of the reagent dispensing mechanisms 7 and 8, the sample dispensing mechanism 11, and the stirring mechanisms 5 and 6, respectively.
- the sample container 15 contains a test sample (specimen) such as blood, and is placed on the rack 16 and carried by the sample transport mechanism 17. Each mechanism is connected to the controller 21.
- the controller 21 is composed of a computer or the like, and controls the operation of each mechanism in the automatic analyzer and performs arithmetic processing for obtaining the concentration of a predetermined component in a liquid sample such as blood or urine.
- the inspection sample analysis processing by the automatic analyzer as described above is generally executed in the following order.
- the sample in the sample container 15 placed on the rack 16 transported near the reaction disk 1 by the sample transport mechanism 17 is transferred to the reaction container 2 on the reaction disk 1 by the sample probe 11 a of the sample dispensing mechanism 11.
- the reagent used for the analysis is dispensed from the reagent bottle 10 on the reagent disk 9 to the reaction container 2 into which the sample has been dispensed by the reagent dispensing mechanisms 7 and 8.
- the mixed solution of the sample and the reagent in the reaction vessel 2 is stirred by the stirring mechanism 5.
- the light generated from the light source 4 a is transmitted through the reaction container 2 containing the mixed liquid after stirring, and the luminous intensity of the transmitted light is measured by the spectrophotometer 4.
- the luminous intensity measured by the spectrophotometer 4 is transmitted to the controller 21 via the A / D converter and the interface. Then, calculation is performed by the controller 21, the concentration of a predetermined component in a liquid sample such as blood or urine is obtained, and the result is displayed on a display unit (not shown) or stored in a storage unit (not shown).
- FIG. 2 is a diagram showing an outline of the autoloader mechanism 100.
- the lid 112 is attached to the reagent probe suction port position of the reagent bottle 10 to seal the inside, and the lid 112 can be removed and installed in the apparatus when set in the automatic analyzer. It is common. However, in recent years, there is a method in which a notch hole is formed in the lid 112 and the reagent probes 7a and 8a are inserted into the notch hole to suck the reagent in the reagent bottle 10. Since the opening of the lid 112 is slightly cut in the reagent, the reagent has minimal contact with the outside air, and the deterioration of the reagent is improved as compared with the conventional case.
- the autoloader mechanism 100 is arranged on the reagent disk 9 and has a configuration as shown in FIG.
- the autoloader mechanism 100 includes a reagent mounting unit 103, a reagent mounting mechanism (transport line) 102, a reagent transport mechanism (reagent transport unit) 101, a needle cleaning tank 108, a needle drying port 109, a column 117, and a metal plate 118. And each of these mechanisms except for the support column 117 is attached to a single metal plate 118.
- the reagent loading unit 103 is a part for an operator to install the reagent bottle 10 when the reagent bottle 10 is put into the automatic analyzer.
- the reagent loading unit 103 is moved vertically in FIG. Be operated.
- the operation range of the reagent loading unit 103 is set within the apparatus by being fastened on the metal plate 118 on which the autoloader mechanism 100 is disposed.
- the reagent mounting unit 103 has a structure in which a plurality of reagent bottles 10 can be installed on a straight line, and is, for example, a tray having a plurality of reagent bottle slots for installing the reagent bottles 10.
- the reagent loading mechanism 102 moves on the rail along the guide installed between the loading position of the reagent bottle 10 into the apparatus and the standby position of the reagent loading section 103 by the power of a motor or the like. It is configured to be able to.
- the reagent transport mechanism 101 is a mechanism for transporting the reagent bottle 10 installed in the reagent mounting unit 103 into the reagent disk 9, and includes a gripper mechanism (gripper unit) 106 that grips the reagent bottle 10, and a lid of the reagent bottle 10.
- a reagent bottle lid opening mechanism (reagent bottle lid opening portion) 104 that opens a notch-like hole in 112, a vertical drive motor 130 (see FIG. 7) that moves the reagent bottle lid opening mechanism 104 up and down, a gripper mechanism 106,
- a horizontal drive motor 131 that drives the reagent bottle lid opening mechanism 104 in the left-right direction in FIG. 2 is used as a component.
- the reagent transport mechanism 101 operates in the left-right direction in FIG. 2 between the position of the reagent mounting unit 103 in FIG. That is, the reagent loading unit 103 moves up and down in FIG. 2, and the reagent transport mechanism 101 operates in the horizontal direction in FIG. 2, so that the operation directions are orthogonal to each other.
- a position where the gripper mechanism 106 grips the reagent bottle 10 and a position where the reagent bottle 10 is carried into and out of the reagent disk 9 are linearly arranged.
- the reagent bottle lid opening mechanism 104 is provided with a needle 300 (see FIG. 7) for incising the reagent bottle lid 112.
- a needle washing tank in which the needle body 105 (see FIG. 9) of the needle 300 after the notch is cut into the lid 112 is arranged in parallel to the operation direction of the reagent transport mechanism 101.
- the cleaning water is removed at the needle drying port 109 arranged in parallel with the operation direction of the reagent transport mechanism 101.
- the needle cleaning tank 108 and the needle drying port 109 are arranged in parallel to the operation direction of the reagent transport mechanism 101.
- the gripper mechanism 106 has a hooking claw for holding the reagent bottle 10, and holds the reagent bottle 10 by hooking the hooking claw on the notch portion of the reagent bottle 10.
- the open / close cover 113 is a cover for preventing the cool air inside the kept reagent disk 9 from escaping, and is normally closed.
- the open / close cover 113 is opened and operates so that the reagent bottle 10 can be loaded into and unloaded from the reagent disk 9.
- a button switch (not shown) of the apparatus is first pressed.
- the device recognizes that the first press of the button switch has been performed by the operator.
- the reagent loading mechanism 102 operates, the reagent loading unit 103 starts to move from the standby position, and moves to the front of the apparatus (lower side in FIG. 2).
- the operator After the reagent loading unit 103 arrives in front of the apparatus, the operator installs the reagent bottle 10 in the reagent loading unit 103. After installing the required number of reagent bottles 10 in the reagent mounting unit 103, the operator presses the button switch again.
- the reagent loading unit 103 moves to a position below the reagent bottle lid opening mechanism 104.
- the reagent bottle lid opening mechanism 104 is lowered toward the lid 112 of the reagent bottle 10, and the needle body 105 opens a notch that allows the reagent probes 7 a and 8 a to be inserted into the lid 112.
- the reagent bottle lid opening mechanism 104 rises, the reagent transport mechanism 101 moves to the position of the needle cleaning tank 108 in order to clean the needle body 105, and the needle body 105 Wash. Thereafter, the needle body 105 is moved to the needle drying port 109 to dry the needle body 105.
- the reagent loading mechanism 102 operates the reagent loading unit 103 to move the cut reagent bottle 10 to a position below the gripper mechanism 106. Thereafter, the gripper mechanism 106 descends, grasps the reagent bottle 10, and then opens the opening / closing cover 113. Thereafter, the gripper mechanism 106 moves up, moves to the position of the openable opening / closing cover 113, and carries the reagent bottle 10 conveyed to the position of the empty reagent disk 9. After carrying in, the gripper mechanism 106 is returned to the position of the reagent mounting unit 103 again.
- the above is the operation of opening the lid 112 of the reagent bottle 10 and the operation of carrying it into the reagent disk 9 from the installation of the reagent bottle 10 in the autoloader mechanism 100.
- the reagent bottle 10 is carried out in the following flow.
- the carry-out timing of the reagent bottle 10 may be carried out after the end of the last dispensing of the reagent dispensing mechanisms 7 and 8 or after the output of the analysis result even during the analysis.
- the controller 21 opens the opening / closing cover 113.
- the reagent transport mechanism 101 moves to the position of the openable opening / closing cover 113.
- the empty reagent bottle 10 is gripped by the gripper mechanism 106.
- the reagent loading unit 103 moves from the standby position and stops at a position where the empty reagent bottle slot of the reagent loading unit 103 is below the track of the gripper mechanism 106.
- the reagent transport mechanism 101 moves to the position of the reagent loading mechanism 102 while holding the empty reagent bottle 10 by the gripper mechanism 106. In parallel with this, the opening / closing cover 113 is closed. Thereafter, the empty reagent bottle 10 is placed in an empty reagent bottle slot of the reagent mounting unit 103 by the gripper mechanism 106. Thereafter, the reagent loading mechanism 102 returns to the standby position.
- the operator is notified that the empty reagent bottle 10 can be taken out. Upon receiving this notification, the operator takes out the empty reagent bottle 10 from the apparatus.
- the reagent disk 9 One or several empty reagent slots are provided for the installable number. Then, the reagent bottle 10 installed in the reagent loading unit 103 is loaded into the reagent disk 9 without cutting the lid 112, and the empty reagent bottle 10 is gripped by the gripper mechanism 106 and placed on the reagent loading unit 103. After that, the operator carries out the empty reagent bottle 10. After unloading, the reagent bottle 10 that is not cut in the reagent disk 9 can be returned to the empty reagent slot again. If an empty slot is provided in the reagent mounting unit 103, the same operation is possible.
- the reagent probe is inserted into the lid 112 at a high speed. Therefore, when the notch 112a of the lid 112 is opened at the center of the lid 112 as shown in FIG. 3, the reagent probes 7a and 8a normally pass through the center as shown in FIG. On the other hand, as shown in FIG. 5, when the notch 112a of the lid 112 is opened out of the center of the lid 112, the tip of the reagent probe 8a is easily caught on the lid 112 as shown in FIG. In this case, there is a risk of bending the reagent probes 7a and 8a.
- the nozzle diameters of the reagent probes 7a and 8a used in recent years are about 1 mm, and their buckling strength is not strong. For this reason, in order to repeat the operation of performing the hole drilling in the lid 112 and inserting the reagent into the lid 112 and discharging the reagent, it is necessary to wash and use for a long time. Damage to 7a and 8a must be avoided as much as possible.
- the reagent bottle lid opening mechanism 104 allows the needle body 105 of the needle 300 to be pierced with high reproducibility in the center of the lid 112 and to make a cut-out hole.
- An alignment mechanism for adjusting the position of the needle 300 with respect to the lid 112 of the needle body 105 is provided.
- FIG. 7 shows a configuration for moving the reagent bottle lid opening mechanism 104 up and down.
- the vertical drive motor 130, the pulley 202 that rotates in conjunction with the vertical drive motor 130, the pulley 203 provided in a pair with the pulley 202, and the pulley 202 and the pulley 203 are connected to each other.
- the reagent bottle lid opening mechanism 104 is connected to the belt 204. Therefore, when the vertical drive motor 130 is driven, the reagent bottle lid opening mechanism 104 operates in the vertical direction.
- the vertical drive motor 130 is disposed at the top, the pulley 203 is disposed at the bottom, and the reagent bottle lid opening mechanism 104 is attached to the belt 204.
- the reagent bottle lid opening mechanism 104 is vertically moved.
- the configuration for performing the operation is not limited to the configuration of FIG. For example, even in a configuration using a ball screw or a spline shaft, if the needle body 105 moves up and down, it is possible to make a hole in the lid 112.
- FIGS. 8 is a schematic diagram of a cross section of the lid 112 of the reagent bottle 10
- FIG. 9 is a schematic diagram of the reagent bottle lid opening mechanism 104
- FIG. 10 is an enlarged view of a region A in FIG.
- the lid 112 of the reagent bottle 10 is provided with a lid taper (tapered portion) 112 b formed so as to guide the needle 300 to the center of the lid 112.
- the reagent bottle lid opening mechanism 104 is configured to adjust the position of the needle body 105 relative to the lid 112 so that the needle 300 and the needle body 105 of the needle 300 are inserted into the center of the lid 112.
- the centering mechanism includes a piercing stop 403 and a piercing support portion that supports the piercing stop 403.
- the pierce support portion is fixed to the pierce support 301 that contacts the pierce stop 403, the support plate 302 that supports the pierce support 301, and the pierce stop 403 moves in a direction parallel to the pierce support portion. And a holding plate 303 that restricts the amount of movement of the piercing stopper 403 in the parallel direction.
- the needle 300 includes a needle main body 105 that pierces the lid 112, a piercing shaft 400, a piercing guide 402, a spring 404, and a washer 408.
- the needle body 105 is incorporated at the tip of the piercing shaft 400, and a piercing stopper 403 having a diameter larger than that of the needle body 105 is incorporated at the opposite end.
- a piercing guide 402 is attached to the needle body 105 side of the piercing shaft 400 so as to cover most of the needle body 105.
- a spring 404 is incorporated inside the piercing guide 402.
- the needle body 105 has a structure that can be operated in the vertical direction by the expansion and contraction of the spring 404. When the piercing stopper 403 and the holding plate 303 come into contact with each other, the spring 404 contracts and the needle body 105 jumps out of the piercing guide 402 to the lid 112. It comes to contact.
- the piercing stopper 403 has a shape processed into a tapered shape.
- the pierce support 301 incorporated in the support plate 302 is also tapered.
- the piercing stopper 403 and the piercing support 301 are arranged so as to be fitted to each other, and the piercing stopper 403 is movable up and down by an interval of 304 minutes with respect to the piercing support 301, and is horizontally moved by an interval of 305 and 306 minutes. It is movable. For this reason, the needle 300 can move in the left-right direction like a pendulum with respect to the piercing support 301. When no force is applied, the needle 300 automatically returns to the original position with respect to the pierce support 301 by its own weight.
- the upward movement amount of the piercing guide 402 is until the spring 404 is completely compressed, and the downward movement amount is that the stopper 405 configured integrally with the piercing guide 402 contacts the step portion 407 of the piercing shaft 400. It has become until.
- the amount of movement of this vertical movement is only required to ensure the amount of vertical movement until the needle body 105 penetrates the lid 112 after the tapered portion 406 of the piercing guide 402 is positioned by the lid taper 112b of the lid 112. It is not necessary to raise the piercing guide 402 until the spring 404 is completely compressed. For example, if the stopper is brought into contact with the piercing guide 402 by providing a stopper (not shown) on the piercing shaft 400, damage to the spring 404 can be avoided.
- the diameter ⁇ A of the opening of the piercing support 301 and the diameter ⁇ B of the piercing guide 402 are: ⁇ A> ⁇ B (1) It is desirable to satisfy the relationship.
- the needle 300 for replacement when the needle body 105 or the like is abnormal or worn out can be easily detached, and maintenance can be improved and parts replacement can be simplified. it can.
- the interval 306 between the side surface of the piercing stop 403 and the side surface of the pierce support 301 is The difference D between the central axis of the lid 112 and the central axis of the needle 300 is larger.
- Equation (1) The effects of Equation (1) and Equation (2) will be described with reference to FIG.
- FIGS. 11 to 17 show an example in which the central axis of the needle body 105 and the central axis of the lid 112 are shifted before the lid 112 is drilled.
- FIGS. 11 to 17 show a case where the center of the needle body 105 and the center axis of the lid 112 are misaligned when making a hole in the lid 112 with the needle body 105 in order to realize the hole making operation to the center of the lid 112 with good reproducibility. It is explanatory drawing of.
- Factors causing the center axis of the needle body 105 to deviate from the center axis of the lid 112 include variations in adjustment when each component is mounted, variations in the size of the components themselves, variations in the sizes of the reagent bottle 10 and the lid 112, and needle bodies. There are various causes such as variations in the installation position of the reagent mounting portion 103 of the reagent bottle 10 before the hole is opened at 105. However, making the part tolerances accurate increases costs. In addition, it is practically difficult to eliminate a variation by providing a lot of adjustment time. Therefore, the reagent bottle lid opening mechanism 104 provided with the alignment mechanism as in this embodiment is very useful.
- the reagent bottle lid opening mechanism 104 is lowered to make a hole in the lid 112 from the state shown in FIG. Then, as shown in FIG. 12, instead of the needle body 105, the tapered portion 406 provided in the piercing guide 402 of the needle 300 and the lid taper 112b of the lid 112 first come into contact with each other. Since each component has a tapered shape, the taper portion 406 is inserted as it is toward the center of the lid taper 112b with the taper serving as a guide.
- the pierce stopper 403 is a tapered portion of the pierce support 301 as shown in FIG. Accordingly, the needle 300 is tilted to the left in the drawing using the interval 305 and the interval 306, and the piercing stopper 403 is raised on the tapered surface of the pierce support 301 using the interval 304 and the interval 306.
- the taper portion 406 comes into close contact with the lid taper 112b as shown in FIG.
- the central axis of the needle body 105 is automatically adjusted so that the central axis of the lid 112 and the central axis of the needle body 105 coincide.
- the spring 404 starts to be compressed while the piercing guide 402 and the lid 112 are kept in close contact with each other, and the piercing stopper 403 is raised for an interval of 304 minutes to make close contact with the holding plate 303. To do.
- the reagent bottle lid opening mechanism 104 rises. For this reason, the needle body 105 is detached from the lid 112. Further, since the component parts such as the piercing guide 402 are provided below, and the piercing stopper 403 and the piercing support 301 are provided with a tapered portion, the piercing stopper 403 moves along the tapered surface of the piercing support 301. As shown in FIG. 17, the needle body 105 can return to the vertical arrangement with good reproducibility by utilizing its own weight. Therefore, the hole-drilling operation of the lid 112 can be repeatedly performed while automatically aligning.
- the piercing shaft guide 321 can be provided and the inclination of the whole needle body 105 can be corrected. In this case, it is desirable to provide a gap 309 between the pierce shaft guide 321 and the pierce shaft 400 so that a certain degree of inclination is allowed.
- FIGS. 19 to 23 are schematic views showing another example of the reagent bottle lid opening mechanism.
- the opening of the support plate 302A may have a tapered shape
- the piercing stopper 403A may have a block shape.
- the center of the lid 112 is automatically formed at the time of drilling.
- the axis and the central axis of the needle body 105 can be made to coincide.
- the tapered piercing support 301 is not provided, and only the tapered piercing stopper 403 may be provided. Also in this case, since the piercing stopper 403 can move freely in the vertical and horizontal directions with respect to the support plate 302 by the piercing stopper 403 having a tapered shape, the center axis of the lid 112 and the center of the needle body 105 are formed when drilling. The axis automatically matches.
- a plurality of balls 320 are fixed to the holding plate 303 on the upper and lower sides of the piercing stopper 403B, and the piercing shaft 400 is slid left and right between the intervals 307 and the piercing stopper 403 between the intervals 308. It can be set as the structure to be made. Even with such a structure, the center axis of the lid 112 and the center axis of the needle body 105 can be automatically aligned.
- the fixing method of the ball 320 is not limited to the structure in which the ball 320 is fixed to the upper and lower holding plates 303 of the piercing stopper 403B as shown in FIG. 21, but between the holding plate 303 and the piercing stopper 403B as shown in FIG.
- a ball 320 having a size that can be accommodated in the space is arranged so that the ball 320 moves in accordance with the left and right movement of the piercing stopper 403B.
- the ball 320 is arranged only on the upper side of the piercing stopper 403B, and after the piercing stopper 403B is lifted together with the ball 320 after contacting the lid 112, the piercing stopper 403B moves to the left and right. You can also.
- the reagent bottle lid opening mechanism 104 having the needle 300 for making a hole in the lid 112 of the reagent bottle 10 carried into the reagent disk 9 is the needle body of the needle 300.
- An alignment mechanism that adjusts the position of the needle 300 with respect to the lid 112 is provided so that the needle 105 is stuck in the center of the lid 112.
- the operation of each mechanism in the apparatus is also performed at high speed, and the reagent probes 7a and 8a are also operated at higher speed than before.
- the reagent probes 7a and 8a are lowered at a high speed into a small hole formed by making a cut 112a in the lid 112 of the reagent bottle 10, and perform a suction operation. For this reason, the reagent probes 7a and 8a may be damaged unless the notch 112a of the lid 112 of the reagent bottle 10 is accurately opened at the center of the lid 112. In order to provide a highly reliable device, it is required to repeatedly make a hole in the center of the lid 112 with high accuracy.
- the center axis of the needle body 105 is automatically set to the center of the lid 112.
- the alignment is performed so as to coincide with the axis, and the drilling operation is performed after alignment. Therefore, it is possible to repeatedly make a hole in the center of the lid 112 of the reagent bottle 10 with high accuracy. Therefore, reagent dispensing by the reagent probes 7a and 8a can be performed accurately at high speed and repeatedly, and the processing capacity of the automatic analyzer can be improved.
- the centering mechanism is provided at the end of the needle 300 opposite to the needle body 105, and has a piercing stop 403 having a diameter larger than that of the needle body 105, and a piercing support portion that supports the piercing stop 403. Since the piercing stopper 403 is supported with respect to the piercing support portion so as to be movable in a direction perpendicular to and parallel to the central axis of the needle 300, the piercing stopper 403 can freely move in the vertical and horizontal directions with respect to the piercing support portion. Can be moved to. Therefore, the center axis of the needle body 105 is automatically aligned so as to coincide with the center axis of the lid 112, and it is possible to repeatedly make a hole in the center of the lid 112 of the reagent bottle 10 with high accuracy.
- the piercing support portion and the piercing stopper 403 of the alignment mechanism is tapered, a smooth alignment operation is performed, and the notch 112a is made in the center of the lid 112 more accurately and repeatedly. Can do.
- the pierce support portion is fixed to the support plate 302, the support plate 302 that supports the pierce support 301, and the pierce support 403.
- a holding plate 303 that restricts the amount of movement of the piercing stopper 403 in the parallel direction when moved in the parallel direction, the distance between the opening and the needle 300, the side surface of the piercing stopper 403, and the side surface of the pierce support 301 Is larger than the difference between the central axis of the lid 112 and the central axis of the needle 300, so that unnecessary portions can be prevented from contacting during alignment, and smoother alignment is achieved. be able to.
- the needle 300 is disposed in the piercing guide 402, the piercing guide 402 that covers the needle body 105, the piercing shaft 400 that supports the needle body 105, the piercing shaft 400 that supports the needle body 105, and the needle body 105.
- a spring 404 that presses toward the piercing shaft 400 side. When the piercing stopper 403 and the holding plate 303 come into contact with each other, the spring 404 contracts and the needle body 105 comes into contact with the lid 112, so that the needle body 105 becomes unnecessarily large. Contact with the lid 112 is suppressed. For this reason, damage to the needle body 105 can be further reduced, and a highly accurate drilling operation can be performed over a longer period.
- the lid 112 of the reagent bottle 10 has a lid taper 112b
- the piercing guide 402 has a taper portion 406, and the needle 300 is covered by the lid taper 112b of the lid 112 and the taper portion 406 of the piercing guide 402.
- these tapers serve as guides for smoother alignment, and alignment can be performed more easily and reliably.
- the needle 300 automatically returns to the original position after the hole of the lid 112 is formed, so that the needle 300 is not held while the center axis is shifted, and smooth alignment can be performed smoothly. .
- the operator directly inputs the reagent bottle 10 into the reagent disk 9. This eliminates the need to perform the operation, and the loading of the reagent bottle 10 from the opening of the reagent bottle 10 to the reagent disk 9 is automatically performed, thereby reducing the burden on the operator.
- the positional relationship between the needle body 105 and the piercing guide 402 is the height from the upper surface of the lid 112 to the portion to be cut or the lid taper. Since it is determined by the shape and angle of 112b and the shape of the tapered portion 406 according to the shape and angle, it is not limited to the above-described embodiment.
- the needle body 105 is described as one, when there are two lids of the reagent bottle 10, two needle bodies 105 are attached, and the reagent bottle lid opening mechanism 104 is moved downward so that the two lids are attached. It can be set as the structure which opens a hole simultaneously. Further, two needle cleaning tanks 108 and needle drying ports 109 can be installed at intervals between the needle main bodies 105. Thereby, since it is possible to perform cleaning and drying in one up-and-down operation, it is possible to shorten the loading time.
- Reagent mounting mechanism (conveyance line) 103 ... Reagent mounting part 104 ... Reagent bottle lid opening mechanism (Reagent bottle lid opening part) 105 ... Needle body 106 ... Gripper mechanism (gripper part) DESCRIPTION OF SYMBOLS 108 ... Needle washing tank 109 ... Needle drying port 111 ... Suction port 112 ... Cover 112a ... Notch 112b ... Cover taper (taper part) 113 ... Opening / closing cover 117 ... Post 118 ... Metal plate 130 ... Vertical drive motor 131 ... Horizontal drive motor 202, 203 ... Pulley 204 ... Belt 300 ... Needle 301 ... Piercing support 302, 302A ...
- Support plate 303 ... Holding plate 304, 305, 306, 307, 308, 309 ... spacing 320 ... ball 321 ... piercing shaft guide 400 ... piercing shaft 402 ... piercing guide 403, 403A, 403B ... piercing stopper 404 ... spring 405 ... stopper 406 ... taper 407 ... step 408 ... washer
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Abstract
Description
本発明は、上記課題を解決する手段を複数含んでいるが、その一例を挙げるならば、試料と試薬とを複数の反応容器に各々分注して反応させ、この反応させた液体を測定する自動分析装置であって、前記試薬を収容した試薬ボトルを収容するための試薬ディスクと、前記自動分析装置に投入されて前記試薬ディスクへ搬入される前記試薬ボトルの蓋に穴をあけるためのニードルを有する試薬ボトル蓋開栓部とを備え、前記試薬ボトル蓋開栓部は、前記ニードルが前記蓋の中心に刺さるよう前記ニードルの前記蓋に対する位置を調整する調芯機構を有することを特徴とする。
φA>φB ・・・(1)
の関係を満たすことが望ましい。この式(1)の関係を満たすことによって、ニードル本体105等に異常または消耗が生じた際の交換のためのニードル300の脱着が容易になり、メンテナンス向上や部品交換の簡易化を図ることができる。
D≦φA-φC ・・・(2)
の関係式を満たせば、自動での調芯は可能である。
2…反応容器
3…洗浄機構
4…分光光度計
4a…光源
5,6…撹拌機構
7,8…試薬分注機構
7a,8a…試薬プローブ
9…試薬ディスク
10…試薬ボトル
11…サンプル分注機構
11a…サンプルプローブ
13…洗浄槽
15…試料容器
16…ラック
17…試料搬送機構
18…試薬用シリンジ
19…試料用シリンジ
20…洗浄用ポンプ
21…コントローラ
30,31,32,33…洗浄槽
100…オートローダー機構
101…試薬搬送機構(試薬搬送部)
102…試薬搭載機構(搬送ライン)
103…試薬搭載部
104…試薬ボトル蓋開栓機構(試薬ボトル蓋開栓部)
105…ニードル本体
106…グリッパー機構(グリッパー部)
108…ニードル洗浄槽
109…ニードル乾燥口
111…吸引口
112…蓋
112a…切り込み
112b…蓋テーパ(テーパ部)
113…開閉カバー
117…支柱
118…金属板
130…上下駆動モータ
131…水平駆動モータ
202,203…プーリ
204…ベルト
300…ニードル
301…ピアス支え
302,302A…支え板
303…抑え板
304,305,306,307,308,309…間隔
320…ボール
321…ピアスシャフトガイド
400…ピアスシャフト
402…ピアスガイド
403,403A,403B…ピアス止め
404…バネ
405…ストッパ
406…テーパ部
407…段差部
408…ワッシャー
Claims (9)
- 試料と試薬とを複数の反応容器に各々分注して反応させ、この反応させた液体を測定する自動分析装置であって、
前記試薬を収容した試薬ボトルを収容するための試薬ディスクと、
前記自動分析装置に投入されて前記試薬ディスクへ搬入される前記試薬ボトルの蓋に穴をあけるためのニードルを有する試薬ボトル蓋開栓部とを備え、
前記試薬ボトル蓋開栓部は、前記ニードルが前記蓋の中心に刺さるよう前記ニードルの前記蓋に対する位置を調整する調芯機構を有する
ことを特徴とする自動分析装置。 - 請求項1に記載の自動分析装置において、
前記調芯機構は、前記ニードルの反対側の端部に設けられ、前記ニードルより径の太いピアス止めと、このピアス止めを支えるピアス支え部と、を有し、
前記ピアス止めは前記ニードルの中心軸に垂直な方向および平行な方向に移動可能となるよう前記ピアス支え部に対して支持されている
ことを特徴とする自動分析装置。 - 請求項2に記載の自動分析装置において、
前記調芯機構の前記ピアス支え部と前記ピアス止めとのうち少なくとも一方がテーパ形状である
ことを特徴とする自動分析装置。 - 請求項3に記載の自動分析装置において、
前記ピアス支え部は、前記ピアス止めと接するテーパ形状のピアス支えと、このピアス支えを支持する支え板と、この支え板に固定され、前記ピアス止めが前記ピアス支え部に対して前記平行な方向に移動したときに前記ピアス止めの平行な方向の移動量を制限する抑え板とを有し、
前記ピアス支え部に設けられた開口部と前記ニードルとの間隔、および前記ピアス止めの側面と前記ピアス支えの側面との間の間隔は、前記蓋の中心軸と前記ニードルとの中心軸の差分より大きい
ことを特徴とする自動分析装置。 - 請求項4に記載の自動分析装置において、
前記ニードルは、前記蓋に刺さるニードル本体と、このニードル本体を支持するピアスシャフトと、前記ニードル本体を覆うピアスガイドと、このピアスガイド内に配置され、前記ニードル本体を前記ピアスシャフト側に押圧するばねと、を有し、
前記ピアス止めと前記抑え板とが接触すると前記ばねが縮み、前記ニードル本体が前記蓋に接触する
ことを特徴とする自動分析装置。 - 請求項5に記載の自動分析装置において、
前記試薬ボトルの前記蓋は、テーパ部を有し、
前記ピアスガイドは、テーパ部を有し、
前記蓋のテーパ部と前記ピアスガイドのテーパ部とで、前記ニードルが前記蓋の中心に刺さるよう位置決めがなされる
ことを特徴とする自動分析装置。 - 請求項2に記載の自動分析装置において、
前記調芯機構の前記ピアス支え部は、前記ピアス止めに接する複数のボールと、このボールを保持する支え板とで構成される
ことを特徴とする自動分析装置。 - 請求項1に記載の自動分析装置において、
前記ニードルは、前記蓋の穴あけ後に自動で元の位置に戻る
ことを特徴とする自動分析装置。 - 請求項1に記載の自動分析装置において、
前記自動分析装置内に前記試薬ボトルを投入する際に前記試薬ボトルを設置するための試薬搭載部と、
この試薬搭載部に設置された前記試薬ボトルを前記試薬ディスクに搬送するための試薬搬送部であって、前記試薬ボトルを把持するグリッパー部および前記試薬ボトル蓋開栓部を有する試薬搬送部とを備えた
ことを特徴とする自動分析装置。
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EP17752959.1A EP3418752B1 (en) | 2016-02-19 | 2017-01-31 | Automated analysis device |
CN201780010373.9A CN108603894B (zh) | 2016-02-19 | 2017-01-31 | 自动分析装置 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0531599U (ja) * | 1991-09-30 | 1993-04-27 | 住友電気工業株式会社 | ピペツトノズルとノズルホールダーの構造 |
JPH0618531A (ja) * | 1992-04-09 | 1994-01-25 | F Hoffmann La Roche Ag | 試薬キットと自動分析装置 |
JP2004125677A (ja) * | 2002-10-04 | 2004-04-22 | Hitachi High-Technologies Corp | 自動分析装置 |
WO2009017065A1 (ja) * | 2007-07-31 | 2009-02-05 | Olympus Corporation | 分析装置、洗浄装置、分注装置、攪拌装置および容器 |
JP2010107308A (ja) | 2008-10-29 | 2010-05-13 | Sysmex Corp | 検体処理装置および検体吸引装置 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4799853A (en) * | 1986-10-06 | 1989-01-24 | Xerox Corporation | Self-centering end effector |
US5171530A (en) * | 1990-02-28 | 1992-12-15 | The Perkin-Elmer Corporation | Vial locator and sensor |
JPH0767640B2 (ja) | 1991-06-27 | 1995-07-26 | 株式会社菊水製作所 | 回転式粉末成形機の下杵自動取り出し方法及びその装置 |
JP2945848B2 (ja) * | 1995-04-12 | 1999-09-06 | アロカ株式会社 | 分注装置 |
JP4033060B2 (ja) | 2003-07-17 | 2008-01-16 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
CA3122671A1 (en) * | 2005-12-21 | 2008-05-15 | Meso Scale Technologies, Llc. | Assay apparatuses, methods and reagents |
JP4861762B2 (ja) * | 2006-07-13 | 2012-01-25 | ベックマン コールター, インコーポレイテッド | 自動分析装置 |
JP6649088B2 (ja) | 2014-01-07 | 2020-02-19 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
-
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0531599U (ja) * | 1991-09-30 | 1993-04-27 | 住友電気工業株式会社 | ピペツトノズルとノズルホールダーの構造 |
JPH0618531A (ja) * | 1992-04-09 | 1994-01-25 | F Hoffmann La Roche Ag | 試薬キットと自動分析装置 |
JP2004125677A (ja) * | 2002-10-04 | 2004-04-22 | Hitachi High-Technologies Corp | 自動分析装置 |
WO2009017065A1 (ja) * | 2007-07-31 | 2009-02-05 | Olympus Corporation | 分析装置、洗浄装置、分注装置、攪拌装置および容器 |
JP2010107308A (ja) | 2008-10-29 | 2010-05-13 | Sysmex Corp | 検体処理装置および検体吸引装置 |
Non-Patent Citations (1)
Title |
---|
See also references of EP3418752A4 |
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