WO2016136349A1 - 光照射装置 - Google Patents
光照射装置 Download PDFInfo
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- WO2016136349A1 WO2016136349A1 PCT/JP2016/051933 JP2016051933W WO2016136349A1 WO 2016136349 A1 WO2016136349 A1 WO 2016136349A1 JP 2016051933 W JP2016051933 W JP 2016051933W WO 2016136349 A1 WO2016136349 A1 WO 2016136349A1
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- WIPO (PCT)
- Prior art keywords
- light
- light irradiation
- polymer gel
- gel layer
- led
- Prior art date
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Classifications
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Definitions
- the present invention relates to a light irradiation apparatus used for treatment and barber beauty, which mainly irradiates light to affected areas of human and animal skin.
- phototherapy it is used for various purposes such as treatment of diseases such as newborn jaundice, psoriasis and acne, pain relief and beauty.
- Green light and bluish white light are used to treat newborn jaundice
- ultraviolet light is used to treat psoriasis
- blue light red light and yellow light are used to treat acne.
- Various light sources are used depending on the application.
- the affected part is arranged at a certain distance from a fixed light source and irradiated with light.
- a light source such as an excimer lamp or an arc lamp
- the affected part is arranged at a certain distance from a fixed light source and irradiated with light.
- light is applied to other than the affected part, and therefore, it is necessary to take measures such as covering the other part with a light shielding object like an eye mask for protecting the eyes.
- the irradiation intensity varies depending on the location of the affected part, and it is difficult to uniformly irradiate the affected part with light.
- a lamp-type device is large and has many auxiliary devices such as a power source and a cooling device, the installation area is large and a space is required and the price is high.
- the light applied to the affected area becomes spot light, so it is necessary to scan the spot light to irradiate the affected area with a large area, and the equipment is complicated. It becomes expensive.
- the efficiency of sending light to the optical fiber is relatively low, so the irradiation power is inevitably low, and is only suitable for treatment for a relatively long time.
- the light-emitting diode is smaller than other light sources, and can irradiate the affected part having a curved surface with different numbers of elements and arrangement.
- Patent Document 1 discloses a light irradiation device in which a laser and an LED are arranged on a flexible substrate as a light emitting light source and wound around an affected area.
- Patent Document 2 discloses a facial light irradiation device in which an LED is arranged on a flexible substrate as a light emitting light source and used while covering the face.
- Patent Document 3 discloses a flexible light irradiation apparatus in which a large number of LEDs serving as light emitting light sources are arranged on a flexible substrate, and this is wound around an affected area and irradiated with light.
- Patent Document 4 on the premise of application to the head, a light irradiation device in which an LED serving as a light emitting light source is arranged inside a hat is arranged.
- Patent Document 5 discloses a light irradiation device in which an LED serving as a light emitting light source is disposed on a flexible substrate, and a light transmitting material is sandwiched between the affected part and the LED to transmit heat generated from the LED to the affected part.
- Non-Patent Document 1 describes a method of treating methicillin-resistant Staphylococcus aureus (MRSA) -infected skin ulcers using near-ultraviolet light from LEDs.
- MRSA methicillin-resistant Staphylococcus aureus
- the affected part In phototherapy, it is required that the affected part can be uniformly irradiated with the minimum necessary amount of light. Excessive irradiation may cause side effects such as “sunburn” on the affected area. If the irradiation dose is insufficient, a therapeutic effect cannot be expected.
- parts having curved surfaces such as arms and legs.
- Patent Documents 1 and 2 can irradiate light flexibly on the curved surface of the affected part, it is difficult to always keep a certain distance from the affected part due to the structure. is there.
- the present invention has been made in view of the above problems, and its purpose is to provide a light with a simple structure that can uniformly irradiate an affected part having a curved surface and can suppress excessive heating due to light irradiation. It is to provide an irradiation apparatus.
- a light irradiation apparatus is a light irradiation apparatus for irradiating light to an affected area, and includes a plurality of light emitting diodes that generate light, a polymer gel layer containing water, The polymer gel layer has a contact surface that directly or indirectly contacts the affected area, and is formed on the light emitting diode with a substantially constant thickness.
- a light irradiation device having a simple structure can achieve uniform irradiation even on an affected part having a curved surface, and can suppress excessive heating due to light irradiation.
- FIG. 6 is a detailed cross-sectional view illustrating the configuration of the light irradiation device in FIG.
- FIG. 1 is a cross-sectional view illustrating a configuration of a light irradiation apparatus 10 according to the first embodiment.
- FIG. 2 is an enlarged cross-sectional view showing a configuration of a portion including the LED 4 of the light irradiation device 10.
- FIG. 3 is a plan view showing the arrangement of the LEDs 4 with respect to the affected part 2 of the light irradiation device 10.
- a light irradiation apparatus 10 includes a polymer gel layer 3 that covers an affected area 2 of a skin 1 and a light emitting diode (hereinafter referred to as an LED) that is in close contact with the polymer gel layer 3 and serves as a light source. ) 4, a substrate 5 on which the LED 4 is mounted, and a light-emitting diode protective layer (hereinafter, LED protective layer) 6 that covers the mounting surface of the LED 4 on the substrate 5.
- the light irradiation device 10 includes a current control device 8 that lights the LED 4 and a sensor 9 that detects light irradiation intensity and temperature.
- the current control device 8 (energization control unit) controls the irradiation intensity based on the temperature signal and the light amount signal from the sensor 9 installed on the skin 1, and stops the light irradiation when the required dose is reached. can do.
- the sensor 9 may be installed on the substrate 5 instead of on the skin 1 as long as the sensor 9 has only a light irradiation intensity detection function.
- LED4 and substrate 5 The LEDs 4 are mounted on the substrate 5 (on a plane) at almost equal intervals.
- the LED 4 must be selected according to the therapeutic purpose.
- a gallium nitride-based LED emitting blue-violet light (peak wavelength: 410 nm) is used for application to “treatment of methicillin-resistant Staphylococcus aureus (MRSA) -infected skin ulcer”.
- MRSA methicillin-resistant Staphylococcus aureus
- LED 4 can be selected. It is also possible to combine a plurality of LEDs 4 having different wavelength bands.
- LED 4 and the substrate 5 on which the LED 4 is mounted are formed on a 2.8 mm square alumina (Al 2 O 3 ) -based white ceramic substrate 11.
- An LED element mounted in series and covered with a resin dome 14 made of silicone resin was used as the LED 4.
- the LED chip 12 is bonded to the ceramic substrate 11 by a die bond paste (not shown) and connected to an electrode (not shown) by a bonding wire 13.
- the average distance D that is the average value of the distances between the centers of the adjacent LEDs 4 is preferably 3 mm or more and 20 mm or less, and more preferably 5 mm or more and 10 mm or less.
- the substrate 5 is constituted by a copper wiring 16 formed on a polyimide film 15, and the surface of the copper wiring 16 is plated with silver plating 17.
- the silver plating 17 is used to increase the reflectance of the treatment light and reduce the light loss.
- the LED 4 is attached to the copper wiring 16 by solder 18.
- the LED protective layer 6 is made of a silicone resin, and is formed so as to cover the substrate surface in order to prevent corrosion of the silver plating 17 and to ensure insulation and waterproofness of the substrate surface.
- the light irradiation apparatus 10 may be provided with a protective case (not shown) that houses the LED 4 instead of the LED protective layer 6.
- the protective case has flexibility to bend flexibly, and is formed of a material that can prevent corrosion of the silver plating 17, ensure insulation of the substrate surface, and ensure waterproofness, similar to the LED protective layer 6. Yes. Thereby, the waterproofness with respect to LED4 is securable.
- the LED4 is arrange
- the substrate 5 is also processed so as to cover the affected part 2.
- the back surface of the substrate 5 (opposite the LED 4 mounting surface) is in contact with air, but it is preferable to efficiently release the heat generated by the LED 4 to the outside, and heat is applied by applying copper plating to the entire back surface of the substrate 5. It is effective to spread the heat of the LED 4 over the entire substrate 5 by attaching a material having good conductivity.
- the polymer gel layer 3 is a gel layer containing water and is formed into a plate shape by absorbing water into the sodium polyacrylate granules. If it is a polymer with high water absorption like sodium polyacrylate, another absorptive polymer can also be used.
- polyacrylates, polysulfonates, maleic anhydrides, polyacrylamides, polyvinyl alcohols, polyethylene oxides, and many other synthetic polymers polyaspartates, polyglutamates, poly Naturally derived water-absorbing polymers such as alginates, starches and celluloses are known.
- Water is preferably pure water, but can be used as long as it has a low ion content such as tap water. Moreover, as long as it is low concentration, you may be the aqueous solution which added the conventionally well-known chemical
- the lower surface (the surface in contact with the affected part 2) is preferably covered with a polymer gel holding layer 7 which is a transparent film that transmits light in a therapeutically effective wavelength band. .
- the upper and lower surfaces may be covered.
- the wavelength band effective for treatment is preferably 400 nm or more and 430 nm or less, and more preferably 380 nm or more and 450 nm or less.
- the wavelength band effective for treatment when other LEDs are used, it is desirable that the wavelength is ⁇ 20 nm with respect to the peak wavelength, and it is more desirable that the wavelength band be transparent within a range of approximately ⁇ 30 nm. .
- the polymer gel layer 3 has a contact surface that comes into direct contact with the affected area 2 and preferably covers the affected area 2 completely. However, the polymer gel layer 3 may not contact the affected part 2 directly but may contact the affected part 2 indirectly. For example, a thin film may be interposed between the polymer gel layer 3 and the affected part 2, or the polymer gel layer 3 may be brought into contact with the affected part 2 after applying cream or the like to the affected part 2. Since most of the treatment light is confined in the polymer gel layer 3, the portion not covered with the polymer gel layer 3 is hardly irradiated with light. Therefore, the affected part 2 to be treated needs to be covered with the polymer gel layer 3. In order to perform light irradiation with sufficient intensity for treatment, it is preferable to cover the portion indicated by the outline separated by a certain distance from the portion indicated by the outline surrounding the affected area 2 in FIG.
- the polymer gel layer 3 is mostly water, and water absorbs heat from light, so that overheating of the affected part 2 by light can be suppressed. Without the polymer gel layer 3, the heat generated by light absorption in the affected area 2 can only be cooled by the blood flow in the body. However, exhaust heat to the surface side of the affected area 2 can be expected by the polymer gel layer 3. From the viewpoint of the cooling effect, the polymer gel layer 3 is preferably as thick as possible. The thicker the light irradiation intensity, the more uniform, but the thickness may be limited depending on the shape of the affected part 2. Moreover, although the thickness T of the polymer gel layer 3 depends on the affected part 2 to be irradiated, for example, it is preferably 1 mm or more and 20 mm or less, and more preferably 3 mm or more and 12 mm or less.
- the time of light irradiation can be extended by cooling the polymer gel layer 3 before irradiating light and lowering the temperature.
- the allowable range of temperature rise can be expanded from about 15 ° C. to about 30 ° C. by cooling to 10 ° C. with respect to room temperature of 25 ° C.
- the polymer gel layer 3 was cooled to 10 ° C. and then irradiated with light.
- the cooling temperature depends on the affected area 2 to be irradiated, the maximum allowable temperature, and the like, but for example, it is preferably cooled to 0 ° C. or higher and 20 ° C. or lower, more preferably 5 ° C. or higher and 15 ° C. or lower.
- the thickness T of the polymer gel layer 3 is an important parameter for uniformly irradiating the affected area 2 with light.
- the average distance D between the individual LEDs 4 is preferably 0.5 ⁇ T / D, and more preferably 0.8 ⁇ T / D.
- the sensor 9 monitors the temperature of the affected area 2 and / or the intensity of irradiated light. Conventionally known ones can be used as long as the light irradiation to the affected part 2 is not affected. However, the sensor 9 needs to have water resistance.
- the sensor 9 can omit the irradiation light intensity sensing function.
- the output of the LED 4 is stable, and if the relationship between the output and the light intensity is calibrated in advance, a predetermined irradiation intensity can be obtained by passing a specified current, and the required dose is irradiated by time control. be able to.
- the current amount is not controlled by the current control device 8, but the light irradiation is interrupted so that the temperature does not exceed the predetermined temperature by turning on / off the current. . Thereby, the affected part 2 and the surrounding skin 1 can be prevented from becoming hot.
- the temperature monitor can be omitted. If the total irradiation amount is small and the temperature can be kept at 40 ° C. or lower even at the end of irradiation, the average irradiation power is low, and the temperature does not rise above 40 ° C. even if continuous irradiation is performed, or the average irradiation by pulse drive Temperature monitoring is not necessary if the temperature does not rise above 40 ° C even if the power is kept low and continuous irradiation is performed. In the case of an emergency where such a prior evaluation is not possible, it is preferable to use the sensor 9.
- the upper limit temperature of 40 ° C. is generally described as a guideline that there will be no burns when irradiated for several tens of minutes, but depending on the situation, the upper limit temperature is kept lower. It may be necessary. On the contrary, if it is in a short time, the temperature rise may be allowed a little more.
- the upper limit temperature depends on the affected area 2 to be irradiated, but is preferably 51 ° C. or lower, and more preferably 44 ° C. or lower, for example.
- the current control device 8 is a constant current source that supplies a constant current to the LED element group, and controls the light dose by setting a current supply time with a timer.
- a temperature sensor When using a temperature sensor, set the upper temperature limit, stop energization when approaching the upper limit temperature (for example, 40 ° C (constant temperature)), start energization again when the temperature drops, and the total irradiation time
- the power is turned off and control is performed to notify the end.
- the light irradiation time depends on the affected area 2 to be irradiated, but is preferably, for example, 30 minutes or less, and more preferably 15 minutes or less.
- a temperature monitor and a light irradiation intensity monitor are used in combination (for example, when the sensor 9 is used), an upper limit temperature and a necessary dose amount are set, and the current is controlled so that the upper limit temperature is not reached, while the necessary dose amount is set. When it reaches, irradiation is terminated and control is performed to notify the termination.
- the light irradiation intensity depends on the affected area 2 to be irradiated, but is preferably 10 mW / cm 2 or more and 200 mW / cm 2 or less, and more preferably 50 mW / cm 2 or more and 150 mW / cm 2 or less.
- the necessary dose depends on the affected area 2 which is an irradiation target, for example, is preferably 40 J / cm 2 or more 65 J / cm 2 or less, more preferably 45 J / cm 2 or more 55 J / cm 2 or less.
- the same current can be supplied to all the LEDs 4, and almost the same output can be obtained from each LED 4.
- the voltage may be too high in all series. That is, a plurality of systems in which substantially the same number of LEDs 4 are connected in series are provided. In this case, it is necessary to mount a plurality of constant current power sources capable of outputting the same current. In FIG. 3, 64 LEDs are mounted. When 100 mA is passed through each element, a voltage of about 6.2 V is required for each element. As a result, the series connection requires a high voltage of about 400 V in total, which is dangerous. For this purpose, two lines of 32 wires connected in series were provided, and two identical 200V power supplies were used so that each element could be energized with 100 mA.
- the ulcer formed on the back of a pig was infected with methicillin-resistant Staphylococcus aureus (MRSA), and this embodiment was used for systemic administration of 5-aminolevulinic acid (ALA) and phototherapy using blue-violet light with a wavelength of 410 nm.
- the light irradiation device was applied.
- a part of ALA is converted into protoporphyrin IX (hereinafter referred to as “PpIX”) in the body of MRSA.
- PpIX is a photosensitizer and is decomposed by the blue-violet light, and the active oxygen generated during the decomposition attacks MRSA, so that MRSA can be reduced.
- bacteria having no adverse effect on the cells of the affected area 2 and having antibiotic resistance can be sterilized without causing antibiotic contamination.
- an ulcer of about 50 mm ⁇ 100 mm was formed on the back of two experimental pigs, and this was infected with MRSA.
- One pig was pre-administered with ARA, sedated with a sleeping pill, and irradiated with light in a resting state. I did nothing on the other side. In this state, the change in the size of the ulcer was observed.
- Two series of wires each having 32 LEDs 4 connected in series were provided so that they could be connected to two constant current power sources capable of boosting to 210V, respectively.
- the average distance D between the four LED elements is 10 mm.
- a temperature sensor (sensor 9) and a light intensity sensor (sensor 9) were attached to a normal part close to the affected part 2.
- a thermocouple was used as the temperature sensor.
- the light intensity sensor used was a PN diode. Each calibration was performed in advance between the output in the polymer gel layer 3 and the actual light intensity and temperature.
- the energization time was determined to be 8 minutes.
- the monitored value of the temperature sensor confirmed that the initial temperature increased from 10 ° C. to 39 ° C. by approximately 29 ° C. almost in proportion to the time during the energization for 8 minutes. I think there is no adverse effect of temperature.
- FIG. 4 is a plan view showing the arrangement of LEDs with respect to the affected part of the light irradiation apparatus according to the modification.
- the modification according to the present embodiment is the same as the first embodiment except that the shape of the substrate 5 and the arrangement of the LEDs 4 are different.
- the size and form of the affected area 2 are different for each patient, and it is preferable to prepare the substrate 5 so as to match each shape and to dispose the LED 4.
- changing the shape individually requires board design, is costly and time consuming, and is not suitable for general treatment.
- a large substrate 5 can be formed so as to be compatible with various affected areas 2, but unnecessary light irradiation may be applied to areas other than the affected area 2, and treatment costs also increase.
- Such a plurality of substrates 51 can be used in combination because the polymer gel layer 3 is interposed between the affected part 2 and each substrate 51 to fix the affected part 2 and the substrate 51 to each other and This is to confine the light and make the irradiation intensity uniform to some extent.
- the irradiation time was 11 minutes.
- the sensor 9 was installed in the vicinity of the affected part 2 not covered with the LED 4 so that sufficient light dose was given to the affected part 2. Since the number of LEDs 4 installed outside the affected area 2 is smaller than that in the first embodiment, the light irradiation intensity to the outer peripheral portion of the affected area 2 is reduced. Although the uniformity of the light irradiation intensity seen over the entire surface of the affected area 2 is deteriorated, if this treatment exceeds the required dose, a slight overdose will not cause a significant adverse effect on the affected area. Considering the time and cost of preparing the equipment, it is considered a reasonable option.
- FIG. 5 is a cross-sectional view illustrating a configuration of the light irradiation apparatus 10 according to the second embodiment.
- FIG. 6 is a detailed cross-sectional view showing the configuration of the light irradiation device 10.
- the light irradiation apparatus 10 is different from the first embodiment in the configuration of the substrate 5 and the LED 4.
- the LED chip 12 is mounted on the ceramic substrate 11 and covered with the resin dome 14, and the ceramic substrate 11 is connected to the copper wiring 16 via the solder 18. Connected with.
- the mounting portion of the LED chip 12 becomes thick.
- the portion (substrate portion) constituted by the LED 4, the substrate 5, and the LED protective layer 6 shown in FIG. 1 is also thickened, and the flexibility of the substrate portion is somewhat sacrificed. Therefore, it is desirable to increase the flexibility of the substrate part with respect to the affected part 2 having a larger curvature.
- the LED chip 12 is mounted on the polyimide film 15 without using the ceramic substrate 11 without using the resin dome 14. Such a configuration increases flexibility while sacrificing durability somewhat.
- the copper wiring 16 is formed on the polyimide film 15, and the silver plating 17 is formed on the surface of the copper wiring 16.
- the LED chip 12 is fixed to the copper wiring 16 with a die bond paste 19, and the electrode on the LED chip 12 and the copper wiring 16 on which the silver plating 17 is formed are connected with a bonding wire 13.
- a resin layer 20 is formed on portions of the LED chip 12 and the bonding wire 13 so as to cover and cover the portions with a silicone resin. Furthermore, in order to prevent corrosion of the silver plating 17 and to ensure insulation of the surface of the polyimide film 15, an LED protective layer 6 made of silicone resin is formed thereon so as to coat the surface. In the case where the LED protective layer 6 can be formed to a thickness sufficient to embed the bonding wire 13, the resin layer 20 can be omitted.
- a relatively flat surface can be formed without using a thick coating material, and in the close contact between the substrate portion and the polymer gel layer 3, it is difficult for air to remain at the interface between the close contact portions.
- the cost of the substrate portion can be reduced.
- the flexibility of the substrate portion is high, it can be easily applied to the affected part 2 having a larger curvature.
- the LEDs 4 are arranged so as to enter the polymer gel layer 3.
- the variation in the thickness of the LED chip 12 does not exceed ⁇ 10 ⁇ m, and the thickness of the polymer gel layer 3 is about 10 mm, so this variation can be substantially ignored.
- the thickness of the polymer gel layer 3 is constant and the size of each LED 4 is uniform, light irradiation can be performed while keeping the distance between the LED 4 and the affected part 2 constant.
- 6 ⁇ 6 36 LED chips 12 are formed on the forefoot of a pig with a light irradiation device using the substrate 5 arranged in an array so that the average distance D between the individual LEDs 4 is 7 mm.
- the ulcer of about 20 mm was treated.
- the LED chips 12 were wired so as to be connected in series, and emitted light at 100 mA.
- the required voltage was about 126V.
- the pig is put into a sleep state, a polymer gel layer 3 having a thickness of about 9 mm formed on the affected area 2 is attached to the affected area 2, and an LED substrate including the LED 4 and the substrate 5 is formed thereon. The whole was pressed and fixed with a bandage. Although the LED substrate was greatly curved, energization was performed without any problem.
- the required irradiation time was 12 minutes.
- the temperature rise was 30 ° C. or less.
- the size of the ulcer after irradiation decreased every day in the same manner as in Example 1, and eventually disappeared. As described above, the therapeutic effect was confirmed.
- FIG. 7 is a cross-sectional view illustrating a configuration of the light irradiation apparatus 10 according to the third embodiment.
- the light irradiation apparatus 10 according to the present embodiment is different from the light irradiation apparatus 10 according to the second embodiment in that the sensor 9 is not mounted.
- the irradiation intensity and temperature rise are measured in advance for the polymer gel layer 3 of various sizes, the optimum drive current and irradiation time are narrowed down, and simple current setting is performed. And light therapy was performed by timer control. The therapeutic effect was obtained without problems as in the case of using the sensor 9.
- the longest irradiation time that can be set for the drive current is determined, and even if the set time is set long, the irradiation is controlled to stop at the longest irradiation time.
- the drive current was 100 mA and the irradiation time was 13 minutes.
- the monitored value of the temperature sensor increased by about 32 ° C. from the initial temperature of 10 ° C. to 42 ° C. almost in proportion to the time during the 13-minute energization. I think there is no adverse effect of temperature.
- the emergency stop switch can be operated by the patient so that the patient can stop immediately. In this way, accidents can be prevented and the power supply can be simplified and the overall cost can be reduced.
- the size of the ulcer after irradiation decreased every day in the same manner as in Example 1, and eventually disappeared. As described above, the therapeutic effect was confirmed.
- FIG. 8 is a cross-sectional view illustrating a configuration of the light irradiation apparatus 10 according to the fourth embodiment.
- the light irradiation apparatus 10 is applied to acne treatment.
- acne treatment a 20% aqueous solution of ALA or methylaminolevulinate (MAL) is generally applied to the affected area 2 and left for about 3 hours, followed by irradiation with blue or red light for 15 to 20 minutes. , Once or twice a week.
- MAL methylaminolevulinate
- the entire face is often irradiated with light by a large lamp-shaped light irradiation apparatus. If there are acne on the front face of the face, it is unavoidable, but if there is acne locally, if only that part can be irradiated with light, the load on the patient can be significantly reduced.
- the drug 21 using MAL is applied to the drug application part 7 a on the affected part contact surface of the polymer gel holding layer 7 with respect to the acne in the cheek.
- the drug 21 is applied to the drug application part 3 a on the affected part contact surface of the polymer gel layer 3.
- the polymer gel layer 3 having a thickness of about 7 mm cooled to 15 ° C. is attached to the affected area 2, and the substrate used in the embodiment 1 or 2 thereon. 5 was affixed and irradiated with light.
- blue LED chip 12 suitable for acne treatment was used instead of blue-violet light.
- a blue LED chip 12 having a size of 440 ⁇ m ⁇ 550 ⁇ m was used.
- the size on one substrate was a peak wavelength of 447 nm.
- 6 ⁇ 6 36 LED chips 12 were arranged in an array on the 50 mm square substrate 5 so that the average distance D between the individual LEDs 4 was 10 mm.
- Two lines of 18 wires connected in series were formed, and a current of 50 mA was applied to each of them. The applied voltage was 58V. Due to temperature rise restrictions, the time for one irradiation was 5 minutes. Irradiation was performed three times with a cooling time.
- the monitor value of the temperature sensor increased from the initial temperature of 15 ° C. to 40 ° C. by about 25 ° C. almost in proportion to the time after the energization for 5 minutes. I think there is no adverse effect of temperature.
- This method made it possible to easily perform local light irradiation. The effect was not different from the light irradiation by the conventional lamp.
- red light can be used in the same way for acne treatment.
- Red LEDs can also be used instead of blue LEDs.
- FIG. 9 is a cross-sectional view illustrating a configuration of the light irradiation apparatus 10 according to the fifth embodiment.
- the light irradiation apparatus 10 according to this embodiment is different from the light irradiation apparatus 10 according to the second embodiment in that silica (SiO 2 ) fine particles are formed on the polymer gel layer 3 as shown in FIG.
- the difference is that a light scatterer 22 made of is added.
- the light irradiation intensity can be made uniform by increasing light scattering in the polymer gel layer 3.
- the light intensity variation on the irradiated surface was 11%, but by adding the light scatterer 22, it could be reduced to 7%.
- FIG. 10 is a cross-sectional view illustrating a configuration of the light irradiation apparatus 10 according to the sixth embodiment.
- the light irradiation apparatus 10 is different from the light irradiation apparatus 10 of Embodiment 2 in that the end of the polymer gel layer 3 is covered with a substrate. Although there was no great difference in the therapeutic effect itself, when the end portion is open, light may leak out from the end portion and may be dazzling. However, in this example, this could be avoided.
- LED4 is arrange
- the LED 4 may be at the end as described above, and even when there is no LED 4, the therapeutic effect can be ensured by extending the light irradiation time.
- the control block (current control device 8) of the light irradiation device 10 may be realized by a logic circuit (hardware) formed in an integrated circuit (IC chip) or the like, or software using a CPU (Central Processing Unit). It may be realized by.
- the light irradiation device 10 includes a CPU that executes instructions of a program that is software for realizing each function, and a ROM (Read Only Memory) in which the program and various data are recorded so as to be readable by the computer (or CPU).
- a storage device (these are referred to as “recording media”), a RAM (Random Access Memory) for expanding the program, and the like are provided.
- the objective of this invention is achieved when a computer (or CPU) reads the said program from the said recording medium and runs it.
- a “non-temporary tangible medium” such as a tape, a disk, a card, a semiconductor memory, a programmable logic circuit, or the like can be used.
- the program may be supplied to the computer via an arbitrary transmission medium (such as a communication network or a broadcast wave) that can transmit the program.
- a transmission medium such as a communication network or a broadcast wave
- the present invention can also be realized in the form of a data signal embedded in a carrier wave in which the program is embodied by electronic transmission.
- the light irradiation device 10 is a light irradiation device that irradiates light to an affected area 2, and includes a plurality of light emitting diodes (LEDs 4) that generate light, a polymer gel layer 3 containing water, The polymer gel layer 3 has a contact surface that directly or indirectly contacts the affected part 2 and is formed on the light emitting diode with a substantially constant thickness.
- LEDs light emitting diodes
- the above configuration has the following advantages in spite of the light irradiation device 10 having a simple structure. That is, since the light emitting diode is disposed via the polymer gel layer 3, the affected part 2 having a curved surface can be covered and light can be irradiated. Further, since the light emitting diode is arranged and irradiated through the polymer gel layer 3 having a substantially constant thickness, the affected area 2 can be irradiated uniformly. Furthermore, since it irradiates through the polymer gel layer 3 containing water, it does not need to carry out excessive light irradiation and can suppress the excessive heating by light irradiation.
- the said light emitting diode is arrange
- the polymer gel layer 3 can be made to have an appropriate thickness that is not too thin with respect to the distance between the light emitting diodes, the problem that occurs when the polymer gel layer 3 is too thin is prevented. be able to. That is, when the polymer gel layer 3 is thin, the light emitting diode and the affected part 2 are close to each other, and the problem that the affected part 2 receives a large amount of light irradiation can be prevented. Further, if the thickness T is not kept uniform, the affected area 2 close to the light emitting diode is irradiated with a large amount of light, but the affected area 2 far from the light emitting diode receives a small amount of light irradiation. Can be prevented.
- the polymer gel layer 3 can be easily handled without impeding irradiation by the light emitting diode because it is optically transparent to light in the wavelength band used for treatment.
- the polymer gel layer 3 has a drug application part 3a where a drug is applied to the contact surface, or contains a drug component. You may go out.
- the above configuration eliminates the troublesome preparation step that requires the drug to be taken and placed a certain time before treatment. Moreover, since the medicine 21 can be directly applied to the affected area 2, a high concentration of the medicine can be delivered to the affected area, and the effect of the medicine is not applied to the places other than the affected area 2, and the light hits it. However, side effects (such as sunburn caused by the action of drugs and light) do not occur, and the burden on the patient can be reduced. As described above, the above configuration can be suitably used for the local affected area 2.
- the energization control unit controls the energization of the light-emitting diode so that the temperature rise of the polymer gel layer 3 becomes a certain temperature or less.
- An apparatus 8) may further be provided.
- the light irradiation device 10 may include the sensor 9 for monitoring at least one of the temperature of the affected area 2 and the intensity of irradiated light in the first to fifth aspects.
- the irradiation intensity can be controlled based on the temperature signal and the light amount signal from the sensor 9, and the irradiation can be stopped when the required dose is reached.
- the sensor 9 to interrupt light irradiation so that the temperature does not exceed a predetermined temperature, it is possible to prevent the affected part 2 and the surrounding skin 1 from becoming hot.
- the polymer gel layer 3 may include a light scatterer.
- the light irradiation intensity can be made more uniform by increasing the light scattering in the polymer gel layer 3.
- the light irradiation apparatus 10 according to the eighth aspect of the present invention further includes the plurality of substrates 51 having the same size in the first to seventh aspects, and each substrate may include at least one light emitting diode mounted thereon. Good.
- a plurality of such substrates 51 can be used in combination, because the polymer gel layer 3 is interposed between the affected part 2 and the substrate 51, and fixes the affected part 2 and the substrate 51 to each other and transmits light. This is for confining and making the irradiation intensity uniform to some extent. Therefore, sufficient treatment can be performed by the light irradiation device 10 having a simple structure without cost such as changing the shape of the light emitting diode.
- a light emitting diode protective layer for protecting the light emitting diode may be provided, or a protective case for housing the light emitting diode may be provided.
- the above configuration protects the light emitting diode, so that problems such as corrosion and leakage can be prevented.
- the present invention can be used mainly for the treatment of irradiating light to affected areas of human and animal skin and for barber beauty.
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Abstract
Description
図1~図4に基づき、本発明の実施形態1に係る光照射装置10について説明する。図1は、実施形態1に係る光照射装置10の構成を示す断面図である。図2は、光照射装置10のLED4を含む部分の構成を拡大して示す断面図である。図3は、光照射装置10の患部2に対するLED4の配置を示す平面図である。
LED4は、ほぼ均等な間隔を置いて基板5上(平面上)に実装されている。LED4は治療目的に応じて選択しなければならない。ここでは「メチシリン耐性黄色ブドウ球菌(MRSA)感染皮膚潰瘍治療」へ適用する為、窒化ガリウム系の青紫光を発するLED(ピーク波長410nm)を用いている。他の用途では、窒化ガリウム(AlInGaN)LEDによる紫外LED、青色LED若しくは緑色LED、4元系(AlGaInP)LEDによる赤色LED、黄色LED若しくは緑色LED、又はGaAs系の赤外LED等、目的によって最適なLED4を選択できる。また、異なる波長帯のLED4を複数組み合わせることも可能である。
高分子ゲル層3は、水を含有するゲル層であり、ポリアクリル酸ナトリウム顆粒に水を吸収させ板状に成形したものである。ポリアクリル酸ナトリウムの様に吸水性の高いポリマーで有れば、他の吸収性ポリマーを用いることもできる。ポリアクリル酸塩系以外では、ポリスルホン酸塩系、無水マレイン酸塩系、ポリアクリルアミド系、ポリビニルアルコール系及びポリエチレンオキシド系等多種類の合成ポリマー、並びにポリアスパラギン酸塩系、ポリグルタミン酸塩系、ポリアルギン酸塩系、デンプン系及びセルロース系等の天然由来の吸水ポリマーが知られている。
センサ9は患部2の温度及び/又は照射光強度をモニターするものである。患部2への光照射が影響を受けなければ、従来公知のものを使用できる。但し、センサ9は耐水性を持つ必要がある。
電流制御装置8は、最も単純な形態では、LED素子群に定電流を供給する定電流源であり、電流供給時間をタイマー設定することで、光ドーズ量を制御するものである。温度センサを使用する場合は、温度上限を設定し、その上限温度(例えば40℃(一定温度))に近づくと通電を停止し、温度が下がった時点で再度通電を開始し、総照射時間が設定時間に達した段階で電源をオフし、終了を告知する様な制御を行う。光照射時間としては、照射対象である患部2によるが、例えば、30分以下であることが好ましく、15分以下であることがより好ましい。温度モニター及び光照射強度モニターを併用する場合(例えば、センサ9を使用する場合)には、上限温度及び必要ドーズ量を設定し、上限温度に達しない様に電流を制御しつつ、必要ドーズ量に達した時点で、照射を終了し、終了を告知する制御を行う。光照射強度としては、照射対象である患部2によるが、例えば、10mW/cm2以上200mW/cm2以下であることが好ましく、50mW/cm2以上150mW/cm2以下であることがより好ましい。必要ドーズ量としては、照射対象である患部2によるが、例えば、40J/cm2以上65J/cm2以下であることが好ましく、45J/cm2以上55J/cm2以下であることがより好ましい。
本実施例では、豚の背中に形成した潰瘍にメチシリン耐性黄色ブドウ球菌(MRSA)を感染させ、5-アミノレブリン酸(ALA)の全身投与及び波長410nmの青紫光を用いた光治療に本実施形態の光照射装置を適用した。ALAはその一部がMRSAの体内にて、プロトポルフィリンIX(以下、「PpIX」と記載する)に変換される。PpIXを光増感性物質であり、前記青紫光よって分解され、分解時に発生する活性酸素がMRSAを攻撃することで、MRSAを低減できる。また、患部2の細胞自身には全く悪影響を及ぼさず、且つ、抗生物質耐性を有する細菌を、抗生物質汚染を引き起こす事無く殺菌できる。
図4に基づき、実施形態1の変形例に係る光照射装置10について説明する。図4は、変形例に係る光照射装置の患部に対するLEDの配置を示す平面図である。
図5~図6に基づき、本発明の実施形態2に係る光照射装置10の構成について説明する。図5は、実施形態2に係る光照射装置10の構成を示す断面図である。図6は、当該光照射装置10の構成を示す詳細断面図である。
図7に基づき、本発明の実施形態3に係る光照射装置10の構成について説明する。図7は、実施形態3に係る光照射装置10の構成を示す断面図である。
図8に基づき、本発明の実施形態4に係る光照射装置10の構成について説明する。図8は、実施形態4に係る光照射装置10の構成を示す断面図である。
図9に基づき、本発明の実施形態5に係る光照射装置10の構成について説明する。図9は、実施形態5に係る光照射装置10の構成を示す断面図である。
図10に基づき、本発明の実施形態6に係る光照射装置10の構成について説明する。図10は、実施形態6に係る光照射装置10の構成を示す断面図である。
光照射装置10の制御ブロック(電流制御装置8)は、集積回路(ICチップ)等に形成された論理回路(ハードウェア)によって実現してもよいし、CPU(Central Processing Unit)を用いてソフトウェアによって実現してもよい。
本発明の態様1に係る光照射装置10は、患部2に光を照射する光照射装置であって、光を発生する複数の発光ダイオード(LED4)と、水を含有する高分子ゲル層3とを備え、前記高分子ゲル層3は、患部2に直接的又は間接的に接触する接触面を有するとともに、前記発光ダイオード上にほぼ一定の厚さで形成されていることを特徴とする。
1 皮膚
2 患部
3 高分子ゲル層
3a 薬剤塗布部
4 LED(発光ダイオード)
5 基板
6 LED保護層(発光ダイオード保護層)
7 高分子ゲル保持層
7a 薬剤塗布部
8 電流制御装置(通電制御部)
9 センサ
11 セラミック基板
12 LEDチップ
13 ボンディングワイヤー
14 樹脂ドーム
15 ポリイミドフィルム
16 銅配線
17 銀メッキ
18 ハンダ
19 ダイボンドペースト
20 樹脂層
21 薬剤
22 光散乱体
51 基板
Claims (5)
- 患部に光を照射する光照射装置であって、
光を発生する複数の発光ダイオードと、
水を含有する高分子ゲル層とを備え、
前記高分子ゲル層は、患部に直接的又は間接的に接触する接触面を有するとともに、前記発光ダイオード上にほぼ一定の厚さで形成されていることを特徴とする光照射装置。 - 前記発光ダイオードがほぼ均等な間隔で平面上に配置され、前記高分子ゲル層の厚さTと、隣り合う発光ダイオード間の距離の平均値である平均距離Dとの間に、T/D≧1/2の関係があることを特徴とする請求項1に記載の光照射装置。
- 前記高分子ゲル層の前記接触面に設けられ、治療に使用する波長帯の光を透過させる高分子ゲル保持層を備えることを特徴とする請求項1又は2に記載の光照射装置。
- 前記高分子ゲル層は、前記接触面に薬剤が塗布される薬剤塗布部を有するか、又は薬剤成分を含むことを特徴とする請求項1~3のいずれか1項に記載の光照射装置。
- 前記高分子ゲル層の温度上昇が一定温度以下となる様に、前記発光ダイオードの通電を制御する通電制御部をさらに備えていることを特徴とする請求項1~4のいずれか1項に記載の光照射装置。
Priority Applications (3)
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JP2017501988A JP6466561B2 (ja) | 2015-02-26 | 2016-01-22 | 光照射装置、及び光照射装置の製造方法 |
US15/553,850 US10653890B2 (en) | 2015-02-26 | 2016-01-22 | Light irradiation apparatus |
CN201680010256.8A CN107249688B (zh) | 2015-02-26 | 2016-01-22 | 光照射装置 |
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JP2015-036924 | 2015-02-26 | ||
JP2015036924 | 2015-02-26 |
Publications (1)
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WO2016136349A1 true WO2016136349A1 (ja) | 2016-09-01 |
Family
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PCT/JP2016/051933 WO2016136349A1 (ja) | 2015-02-26 | 2016-01-22 | 光照射装置 |
Country Status (4)
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US (1) | US10653890B2 (ja) |
JP (1) | JP6466561B2 (ja) |
CN (1) | CN107249688B (ja) |
WO (1) | WO2016136349A1 (ja) |
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WO2018154758A1 (ja) * | 2017-02-27 | 2018-08-30 | 潘少輝 | スキンケア装置 |
JP6963858B1 (ja) * | 2021-03-23 | 2021-11-10 | 株式会社キベプランニング | 光および熱供給装置 |
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US10596388B2 (en) | 2016-09-21 | 2020-03-24 | Epistar Corporation | Therapeutic light-emitting module |
US10652866B2 (en) * | 2017-03-20 | 2020-05-12 | Huawei Technologies Co., Ltd. | Systems and methods for supporting asynchronous uplink HARQ and multiple simultaneous transmissions |
CN107890341A (zh) * | 2017-12-08 | 2018-04-10 | 北京理工大学珠海学院 | 一种皮癣的智能检测与治疗装置 |
KR102477173B1 (ko) * | 2019-01-17 | 2022-12-14 | 주식회사 아모센스 | 패치형 피부 케어기기 |
CN109758675A (zh) * | 2019-01-29 | 2019-05-17 | 青岛中腾生物技术有限公司 | 一种自愈合医用凝胶 |
CH716066A1 (de) * | 2019-04-03 | 2020-10-15 | Jk Holding Gmbh | Bestrahlungsmodul sowie Vorrichtung und Verfahren zum Bestrahlen mit medizinisch-kosmetischer Strahlung. |
KR102511473B1 (ko) * | 2019-10-15 | 2023-03-20 | 광주과학기술원 | 피부에 접촉하는 마이크로 발광소자 어레이, 그 어레이의 제조방법. 및 생체삽입형 전자기기의 충전시스템 |
CN114616028A (zh) * | 2019-10-30 | 2022-06-10 | 域点(塞浦路斯)有限公司 | 治疗性辐照装置 |
CN116764091B (zh) * | 2023-08-25 | 2024-01-02 | 深圳市玉玄道科技有限公司 | 一种光电灸理疗装置 |
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Also Published As
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JPWO2016136349A1 (ja) | 2017-11-09 |
JP6466561B2 (ja) | 2019-02-06 |
US20180015298A1 (en) | 2018-01-18 |
CN107249688B (zh) | 2020-02-18 |
US10653890B2 (en) | 2020-05-19 |
CN107249688A (zh) | 2017-10-13 |
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