WO2016112174A3 - Biomarkers of Sleep Deprivation and Cognitive Impairment - Google Patents

Biomarkers of Sleep Deprivation and Cognitive Impairment Download PDF

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Publication number
WO2016112174A3
WO2016112174A3 PCT/US2016/012453 US2016012453W WO2016112174A3 WO 2016112174 A3 WO2016112174 A3 WO 2016112174A3 US 2016012453 W US2016012453 W US 2016012453W WO 2016112174 A3 WO2016112174 A3 WO 2016112174A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomarkers
sleep deprivation
cognitive impairment
identifying
subject suspected
Prior art date
Application number
PCT/US2016/012453
Other languages
French (fr)
Other versions
WO2016112174A2 (en
Inventor
Amita Sehgal
Aalim WELJIE
David F. DINGES
Namni GOEL
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of WO2016112174A2 publication Critical patent/WO2016112174A2/en
Publication of WO2016112174A3 publication Critical patent/WO2016112174A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2864—Sleep disorders

Abstract

The invention includes a method of identifying a subject suspected of sleep deprivation. The method comprises testing a set of biomarkers in a test sample and comparing the test level with the baseline level. The invention also includes a method of identifying a subject suspected of having cognitive impairment as a result of sleep deprivation.
PCT/US2016/012453 2015-01-08 2016-01-07 Biomarkers of Sleep Deprivation and Cognitive Impairment WO2016112174A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562101047P 2015-01-08 2015-01-08
US62/101,047 2015-01-08

Publications (2)

Publication Number Publication Date
WO2016112174A2 WO2016112174A2 (en) 2016-07-14
WO2016112174A3 true WO2016112174A3 (en) 2016-10-27

Family

ID=56356573

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/012453 WO2016112174A2 (en) 2015-01-08 2016-01-07 Biomarkers of Sleep Deprivation and Cognitive Impairment

Country Status (1)

Country Link
WO (1) WO2016112174A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021072554A1 (en) * 2019-10-17 2021-04-22 Biomark Cancer Systems Inc. Method of diagnosing early-stage non-small cell lung cancer
CN114544790B (en) * 2020-11-24 2023-10-24 重庆医科大学 Application of reagent for detecting lysophosphatidylethanolamine (22:5) in blood plasma in preparation of depression detection kit
CN113552260B (en) * 2021-07-23 2023-07-18 江苏省中医院 Application of glycerol-3-galactoside in early diabetic nephropathy diagnosis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080009467A1 (en) * 2000-05-01 2008-01-10 Accera, Inc. Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism
US20110218242A1 (en) * 2005-07-08 2011-09-08 Ellis Lorie A Polyunsaturated Fatty Acids for Treatment of Dementia and Pre-Dementia-Related Conditions
US20130054215A1 (en) * 2011-08-29 2013-02-28 Pulsar Informatics, Inc. Systems and methods for apnea-adjusted neurobehavioral performance prediction and assessment
US20130101984A1 (en) * 2011-10-20 2013-04-25 The Washington University Methods of detecting sleepiness

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080009467A1 (en) * 2000-05-01 2008-01-10 Accera, Inc. Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism
US20110218242A1 (en) * 2005-07-08 2011-09-08 Ellis Lorie A Polyunsaturated Fatty Acids for Treatment of Dementia and Pre-Dementia-Related Conditions
US20130054215A1 (en) * 2011-08-29 2013-02-28 Pulsar Informatics, Inc. Systems and methods for apnea-adjusted neurobehavioral performance prediction and assessment
US20130101984A1 (en) * 2011-10-20 2013-04-25 The Washington University Methods of detecting sleepiness

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BUCKS ET AL.: "Neurocognitive function in obstructive sleep apnoea:A meta-review.", RESPIROLOGY, vol. 18, no. 1, 31 January 2013 (2013-01-31), pages 61 - 70, XP055324793 *
DAVIES ET AL.: "Effect of sleep deprivation on the human metabolome.", PROC. NATL. ACAD. SCI., vol. 111, no. 29, 22 July 2014 (2014-07-22), pages 10761 - 10766, XP055324781 *
GOOLEY ET AL.: "Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics.", J. GENET. GENOMICS, vol. 41, no. 5, 20 May 2014 (2014-05-20), pages 231 - 250, XP055324791 *
THOMANN ET AL.: "Psychomotor Vigilance Task Demonstrates Impaired Vigilance in Disorders with Excessive Daytime Sleepiness.", J CLIN SLEEP MED., vol. 10, no. 9, 15 September 2014 (2014-09-15), pages 1019 - 1024, XP055324787 *
WITTERT: "The relationship between sleep disorders and testosterone in men.", ASIAN J ANDROL., vol. 16, no. 2, 30 April 2014 (2014-04-30), pages 262 - 265, XP055324796 *

Also Published As

Publication number Publication date
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