WO2016015283A1 - 一种樟芝中药牙膏及其制备方法 - Google Patents

一种樟芝中药牙膏及其制备方法 Download PDF

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Publication number
WO2016015283A1
WO2016015283A1 PCT/CN2014/083424 CN2014083424W WO2016015283A1 WO 2016015283 A1 WO2016015283 A1 WO 2016015283A1 CN 2014083424 W CN2014083424 W CN 2014083424W WO 2016015283 A1 WO2016015283 A1 WO 2016015283A1
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toothpaste
concentrated
oil
anthraquinone
chinese medicine
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PCT/CN2014/083424
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English (en)
French (fr)
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赵宗杰
谢海涛
谢龙浩
张向阳
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深圳市仁泰生物科技有限公司
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Priority to PCT/CN2014/083424 priority Critical patent/WO2016015283A1/zh
Publication of WO2016015283A1 publication Critical patent/WO2016015283A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention relates to the technical field of daily chemicals, in particular to an anthraquinone traditional Chinese medicine toothpaste and a preparation method thereof.
  • Antrodiacinnamomea the name of Antrodiacinnamomea, is a rare and medicinal fungus unique to Taiwan, and has great medicinal value. It is known as the “King of Medicine”, “King of Cancer” and “King of Detoxification”. "King of anti-inflammatory” and so on. Modern research has found that Antrodia camphorata contains physiologically active ingredients such as polysaccharides, triterpenoids, sterols and antioxidants, and has the functions of protecting liver, anti-tumor, anti-oxidation, strengthening immunity, anti-allergy, anti-inflammatory, anti-bacterial and anti-viral. In recent years, it has become a hot spot for research and development.
  • Toothpaste is one of the essential items in people's daily life. It can remove plaque and food residue on the tooth surface to clean teeth and protect oral hygiene. Toothpastes are usually made up of a mixture of a friction agent, a moisturizer, a surfactant, a thickener, a sweetener, a preservative, a fragrance, a pigment, deionized water, and the like. Some toothpastes in the market also include some special Chinese medicine ingredients, such as: honeysuckle, Tianqi, two-sided needle, double yellow lotus, white peony, dandelion, aloe vera, etc., the purpose is to slow down and treat bad breath, mouth ulcers, gingivitis, swollen gums and other oral cavity. disease. However, there is no toothpaste for improving oral problems with anthraquinone as a traditional Chinese medicine additive.
  • the object of the present invention is to provide an anti-allergic, anti-inflammatory analgesic, antibacterial, anti-viral and the like, and to prevent and treat oral diseases more effectively.
  • an Antrodia camphorata toothpaste calculated by weight percentage
  • the Antrodia camphorata toothpaste comprises the following components: Antrodia camphora cream is 0.05-3%, friction agent 20-50% , humectant 20-30%, surfactant 2-3%, thickener 1-2%, sweetener 0.05-0.25%, preservative 0.05-0.5%, flavor 1-2%, the balance is water.
  • the Antrodia camphora concentrated paste is a concentrated extract of Antrodia camphorata fermentation supernatant and/or a concentrated extract of Antrodia camphorata mycelium alcohol extract.
  • the friction agent is at least one of calcium carbonate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, silica, and aluminum hydroxide, and more preferably hydrated silica, calcium carbonate or dibasic calcium phosphate dihydrate.
  • the humectant is at least one of glycerin, sorbitol, propylene glycol, polyethylene glycol and water, more preferably sorbitol, polyethylene glycol or glycerin.
  • the surfactant is at least one of sodium lauryl sulfate, sodium methyl cocoyl taurate and sodium lauroyl sarcosinate, more preferably sodium lauryl sulfate.
  • the thickener is at least one of sodium carboxymethylcellulose, staghorn pectin, hydroxyethylcellulose, xanthan gum, guar gum and carrageenan, more preferably sodium carboxymethylcellulose. , xanthan gum or hydroxyethyl cellulose.
  • the sweetener is at least one of saccharin, sodium saccharin, sucrose, xylitol, and cyclamate, and more preferably sodium saccharin.
  • the preservative is at least one of potassium sorbate, sodium benzoate, methyl paraben, hydroxyethyl ester and hydroxypropyl propyl ester, more preferably sodium benzoate or methyl benzoate.
  • the flavor is at least one of peppermint oil, lemon balm oil, spearmint oil, orange oil, orange oil, winter wood oil, clove oil, cinnamon oil, fennel oil, and borneol. More preferably, it is peppermint oil or spearmint oil.
  • the invention also provides a preparation method of the Chinese herbal medicine toothpaste, comprising:
  • Step 1 Provide an ointment concentrate
  • Step 2 The ointment concentrate is mixed with other components to form a toothpaste.
  • the step A1 concentrated cream comprises a fermentation supernatant concentrated paste and/or an anthraquinone mycelium alcohol extract concentrated paste, preferably an anthraquinone mycelium alcohol extract concentrated paste.
  • Antrodia camphorata is subjected to deep liquid fermentation, and the fermentation is matured, filtered, and the supernatant is concentrated to obtain a fermentation supernatant concentrated paste.
  • the method of concentrating the paste is preferably a rotary vacuum concentration method, or a spray drying method, a cooling drying method, or a microwave drying method.
  • Preparation of concentrated extract of Antrodia camphorata alcohol extract Take 1 part by weight of Antrodia camphorata; add 4-8 parts by weight of absolute ethanol and reflux at 80 ⁇ 90 °C for 1 ⁇ 1.5 hours, filter, repeat at least two The above steps are carried out, and the obtained filtrate is combined; the filtrate is evaporated to dryness at 80 to 90 ° C to obtain a concentrated extract of anthrax mycelium alcohol extract.
  • step 2 the method of mixing the prepared yuba concentrated cream with other auxiliary materials to form a toothpaste may be various, including the following three types:
  • Step 12 uniformly disperse the ointment concentrated cream and thickener in a humectant to form a solution I;
  • Step 13 Dissolving a sweetener and a preservative in deionized water to form a solution II;
  • Step 14 Mixing Solution I and Solution II with vigorous stirring to expand into a uniform colloid
  • Step 15 The gel is allowed to stand for a certain period of time to be properly aged, and then the friction agent, the surfactant and the fragrance are added to the gel to be thoroughly stirred and mixed;
  • Step 16 grinding and homogenizing, vacuum degassing to form a toothpaste paste
  • Step 22 Put a moisturizer, a thickener, an anthraquinone concentrated cream, a sweetener, a preservative, and a deionized water into the paste making machine.
  • the friction agent and the surfactant are added, and at the same time, the process starts. Homogenize and homogenize while degassing. After the homogenization is completed, the perfume is added, and the paste is completed in a few minutes of homogenization.
  • Step 32 Prepare an oil phase, an aqueous phase, and a solid phase according to the formulation.
  • Oil phase Premix the thickener and Antrodia cream in a moisturizer
  • water phase dissolve the water-soluble sweetener and preservative in deionized water, and then quantitatively put in other remaining moisturizer
  • solid phase The friction agent and the surfactant are metered into the powder tank;
  • Step 33 When the vacuum degree of the paste making machine is reached, the water phase and the oil phase are sequentially input, and the powder is added after homogenization, and after the second stirring is homogenized, the measured flavor is fine, and the paste is finished in a few minutes.
  • the beneficial effects of the invention are as follows: the anti-allergic, anti-inflammatory, analgesic, antibacterial, anti-viral and the like effects of the anti-allergic, anti-inflammatory analgesic, anti-bacterial, anti-viral, etc., can effectively prevent and treat dental allergies, gum swelling, gum bleeding Or oral diseases such as oral ulcers.
  • Most of the current toothpastes in the market are fluorine-containing, which are used for sterilization, anti-mite and anti-allergy.
  • fluoride is toxic. Fluoride with high concentration is very harmful to the human body. It affects the development of teeth and bones. Fluoride bone disease and dental fluorosis occur. It can cause nausea, vomiting, arrhythmia and other acute fluoride. Poisoned.
  • the antibacterial and anti-allergic effects of the anti-cortisitive Chinese medicine toothpaste provided by the invention not only have the same bactericidal and anti-allergic effects, but also have no toxic and side effects to the human body.
  • Fig. 2 is a graph showing the statistical results of the use of the control group in Test Example 2 of the present invention.
  • Example 1 (based on 500 g toothpaste)
  • Example 3 (based on 500 g toothpaste)
  • anthrax mycelium alcohol extract concentrate and 7.5 g of xanthan gum were premixed in 50 g of sorbitol to prepare an oil phase; 1.25 g of sodium saccharin and 0.25 g of methylparaben were dissolved in deionized water, and then The remaining 75 g of sorbitol is used to prepare an aqueous phase; 150 g and 100 g of dibasic calcium phosphate dihydrate and 15 g of sodium lauroyl sarcosinate are mixed to prepare a solid phase; when the vacuum of the paste machine is reached, the aqueous phase and the oil phase are sequentially introduced. After stirring and homogenizing, the solid phase is added, and after the second stirring is homogenized, 10 g of spearmint is added, and the paste is finished in a few minutes.
  • the fermentation supernatant is prepared by concentrating the concentrated supernatant of Antrodia camphorata. 100 g of sorbitol and 50 g of propylene glycol, 5 g of sodium carboxymethylcellulose and 2.5 g of hydroxyethylcellulose, 5 g of fermentation supernatant, 1 g of sodium saccharin, 0.25 g of sodium benzoate and deionized water are put into the paste machine.
  • anthrax mycelium alcohol extract concentrate 10 g of the fermentation supernatant concentrate and 10 g of sodium carboxymethylcellulose were uniformly dispersed in 100 g of sorbitol and 50 g of polyethylene glycol. Then will be 0.5 G sodium saccharin and 0.5 g of methylparaben were dissolved in an appropriate amount of deionized water; the two solutions were mixed under vigorous stirring to expand into a uniform colloid. After standing for a certain period of time, 180 g of hydrated silica, 7.5 g of sodium lauroyl sarcosinate and 5 g of peppermint oil were added to the colloid, and the mixture was thoroughly stirred, and finally, deionized water was added to prepare 500 g. The mixture was homogenized and vacuum degassed to form a toothpaste paste.
  • the Chinese medicine additive of this formula is mixed into the rat diet.
  • the experiment was divided into 3 groups, 5 mice in each group.
  • the addition amount of Antrodia camphorata is 20g/kg 30g/kg, 45g/kg, feeding the mice for a long time.
  • the animals' expressions and spirits were well responded, and the blood protein, platelets, red blood cells and white blood cells were normal.
  • the maximum addition amount of Antrodia camphorata in this formula toothpaste is 10g/kg, which belongs to the safe addition range. It can be seen that the group of toothpaste is safe and reliable and can be used for a long time.
  • the experimental group 300 people, 50 cases of men and women with gingivitis, 50 cases of men and women with oral ulcers, 50 cases of men and women with sensitive teeth, aged 25-50 years old.
  • Control group 300 people, 50 cases of gingivitis, 50 cases of men and women with oral ulcers, 50 cases of men and women with sensitive teeth, aged 25-50 years.
  • Control group use ordinary toothpaste without any pharmaceutical ingredients and special effects; use the horizontal tremor method to brush the teeth 2 times in the morning and evening, and use 2g of the toothpaste each time.
  • Fig. 1 and Fig. 2 The statistical data of the experimental results are shown in Fig. 1 and Fig. 2. It can be seen that the symptoms of the dental disease in the experimental group are relieved quickly, the efficiency is high, and there is no adverse reaction. In the control group, the symptoms of dental disease using ordinary toothpaste were alleviated slowly, and there was a recurrence. Therefore, the Chinese herbal medicine toothpaste of the present invention can be used for preventing and improving a variety of common oral diseases, and is safe and effective.

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Abstract

日用化学品技术领域，公开了一种樟芝中药牙膏。该樟芝中药牙膏按重量百分比计算包括以下组分：樟芝浓缩膏为0.05-3％、摩擦剂20-50％、保湿剂20-30％、表面活性剂2-3％、增稠剂1-2％、甜味剂0.05-0.25％、防腐剂0.05-0.5％、香精1-2％，余量为水。将樟芝作为药物活性原料，配以牙膏的常规辅料和常规工艺制成的。樟芝药物牙膏具有抗过敏、抗炎镇痛、抗菌、抗病毒等功效，对人体没有任何毒副作用。

Description

一种樟芝中药牙膏及其制备方法 技术领域
本发明涉及日用化学品技术领域，尤其涉及的是一种樟芝中药牙膏及其制备方法。
 背景技术
樟芝学名Antrodiacinnamomea，别名牛樟芝，是中国***有的一种珍稀药用真菌，具有极大的药用价值，被誉为“药王”、“抗癌之王”、“解毒之王”、“抗炎之王”等。现代研究发现，樟芝含有多糖、三萜类、固醇类及抗氧化物质等生理活性成分，具有保肝、抗肿瘤、抗氧化、强化免疫、抗过敏、抗炎、抗菌、抗病毒等功效，近年来成为研究和开发的热点。
牙膏是人们日常生活中必不可少的用品之一，用它可以去除牙齿表面的牙菌斑和食物残渣来清洁牙齿、保护口腔卫生。牙膏通常由摩擦剂、保湿剂、表面活性剂、增稠剂、甜味剂、防腐剂、香精、色素、去离子水等混合而成。市面上有些牙膏还加入一些特殊中药成分，如：金银花、田七、两面针、双黄莲、白芨、蒲公英、芦荟等，目的就是减缓和治疗口臭、口腔溃疡、牙龈炎、牙龈肿痛等口腔疾病。但目前尚未见以樟芝为中药添加剂的用于改善口腔问题的牙膏。
 技术问题
本发明的目的在于提供一种樟芝中药牙膏及其制备方法，该牙膏具有抗过敏、抗炎镇痛、抗菌、抗病毒等功效，能更有效地预防和治疗口腔疾病。
 技术解决方案
本发明目的是通过以下技术方案实现的：一种樟芝中药牙膏，按重量百分比计算，所述樟芝中药牙膏包括以下组分：樟芝浓缩膏为0.05-3%、摩擦剂20-50%、保湿剂20-30%、表面活性剂2-3%、增稠剂1-2%、甜味剂0.05-0.25%、防腐剂0.05-0.5%、香精1-2%，余量为水。
进一步地，所述樟芝浓缩膏为樟芝发酵上清液浓缩膏和/或樟芝菌丝体醇提液浓缩膏。
进一步地，所述摩擦剂为碳酸钙、二水合磷酸氢钙、焦磷酸钙、二氧化硅和氢氧化铝中的至少一种，更优选为水合硅石、碳酸钙或二水合磷酸氢钙。
进一步地，所述保湿剂为甘油、山梨醇、丙二醇、聚乙二醇和水中的至少一种，更优选为山梨醇、聚乙二醇或甘油。
进一步地，所述表面活性剂为十二醇硫酸钠、甲基椰油酰基牛磺酸钠和月桂酰肌氨酸钠中的至少一种，更优选为十二醇硫酸钠。
进一步地，所述增稠剂为羧甲基纤维素钠、鹿角果胶、羟乙基纤维素、黄原胶、瓜尔胶和卡拉胶中的至少一种，更优选羧甲基纤维素钠、黄原胶或羟乙基纤维素。
进一步地，所述甜味剂为糖精、糖精钠、蔗糖、木糖醇、甜蜜素中的至少一种，更优选为糖精钠。
进一步地，所述防腐剂为山梨酸钾盐、苯甲酸钠、羟苯甲酯、羟苯乙酯和羟苯丙酯中的至少一种，更优选为苯甲酸钠或羟苯甲酯。
进一步地，所述香精为薄荷油、柠檬香油、留兰香油、橙油、桔子油、冬木油、丁香油、肉桂油、茴香油和龙脑中的至少一种。更优选为薄荷油或留兰香油。
本发明的还提供该樟芝中药牙膏的制备方法，包括：
步骤1：提供樟芝浓缩膏；
步骤2：将所述樟芝浓缩膏与其他组分混合制成牙膏。
其中，步骤1中樟芝浓缩膏包括发酵上清液浓缩膏和/或樟芝菌丝体醇提液浓缩膏，优选樟芝菌丝体醇提液浓缩膏。
发酵上清液浓缩膏的制备：樟芝通过深层液体发酵，发酵成熟后过滤，取上清液浓缩制得发酵上清液浓缩膏。浓缩制膏的方法优选旋转真空浓缩法，也可以采用喷雾干燥法、冷却干燥法或者微波干燥法等。
樟芝菌丝体醇提取液浓缩膏的制备：取1重量份樟芝菌丝体；加入4-8重量份无水乙醇于80~90℃下回流1~1.5个小时，过滤，重复至少两次以上步骤，合并所得的滤液；将所述滤液在80~90℃下挥干乙醇即得樟芝菌丝体醇提液浓缩膏。
其中，步骤2中将制好的樟芝浓缩膏与其他辅料混合制成牙膏的方法可以为多种，包括如下三种：
一、间歇式（两步法）制膏：
步骤12：将樟芝浓缩膏和增稠剂均匀分散于保湿剂中，形成溶液I；
步骤13: 将甜味剂、防腐剂溶解于去离子水中，形成溶液II；
步骤14：在强力搅拌下将溶液I和溶液II混合使其膨胀成均匀的胶体；
步骤15：将胶体静置一定时间适当陈化，然后加入摩擦剂、表面活性剂和香精于胶体中充分搅拌混合；
步骤16：研磨均质，真空脱气制成牙膏膏体；
二、干法（一步法）制膏
步骤22：将保湿剂、增稠剂、樟芝浓缩膏、甜味剂、防腐剂、去离子水投入制膏机中，当锅内达到一定真空度后投入摩擦剂、表面活性剂，同时开始均质搅拌，边脱气边进行均质。均质完成后加入香料，在均质脱气数分钟完成制膏。
三、湿法（一步法）制膏
步骤32：根据配方制备油相、水相、固相。油相：把增稠剂和樟芝浓缩膏预混于保湿剂中；水相：把水溶性的甜味剂、防腐剂溶于去离子水中，然后定量投入其他余下的保湿剂；固相：把摩擦剂和表面活性剂计量后投入粉料罐中；
步骤33：制膏机真空度达到时，依次投入水相、油相，搅拌均质后加入粉料，二次搅拌均质后就如计量好的香精，均质数分钟完成制膏。
 有益效果
与现有技术相比，本发明的有益效果在于：该樟芝中药牙膏具有抗过敏、抗炎镇痛、抗菌、抗病毒等功效，能有效地预防和治疗牙齿过敏、牙龈肿痛、牙龈出血、口腔溃疡等口腔疾病。目前市场的牙膏大多都是含氟的，用来杀菌、防龋、抗过敏等。但是氟化物是有毒的，浓度高的氟对人体危害很大，轻则影响牙齿和骨的发育，出现氟化骨症、氟斑牙，重则会引起恶心、呕吐、心律不齐等急性氟中毒。而本发明提供的樟芝中药牙膏不仅能达到同样杀菌、抗过敏等作用，且对人体也没有任何毒副作用。
 附图说明
图1是本发明试验例2中实验组的使用结果统计数据图；
图2是本发明试验例2中对照组的使用结果统计数据图。
 本发明的实施方式
为了使本发明所要解决的技术问题、技术方案及有益效果更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
实施例1（以500g牙膏为基准）
取5g樟芝菌丝体粉；加入25g无水乙醇，在80~90℃下回流1~1.5个小时，过滤，重复以上步骤两次，合并所得的滤液；在80~90℃下挥干乙醇即得樟芝菌丝体醇提液浓缩膏。取0.25g樟芝菌丝体醇提液浓缩膏、7.5g 羧甲基纤维素钠和2.5g黄原胶均匀分散于75g山梨醇和50g聚乙二醇中。然后将0.5 g糖精钠和0.25g苯甲酸钠溶解于适量的去离子水中；在强力搅拌下再将两种溶液混合使其膨胀成均匀的胶体。静置一定时间后，加入200g水合硅石、10g月桂酰肌氨酸钠和5g薄荷油于胶体中，充分搅拌均匀，最后加入去离子水配成500g。再研磨均质，真空脱气制成牙膏膏体。
实施例2（以500g牙膏为基准）
取8g樟芝菌丝体粉；加入48g无水乙醇在80~90℃下进行回流，每次1~1.5个小时，过滤，重复两次以上步骤，合并所得的滤液；在80~90℃下挥干乙醇即得樟芝菌丝体醇提液浓缩膏。将70g山梨醇和30g甘油、10g羧甲基纤维素钠、0.4g樟芝菌丝体醇提液浓缩膏、1g糖精钠、0.25g羟苯甲酯和去离子水投入制膏机中，当锅内达到一定真空度后投入100g水合硅石和50g碳酸钙、10g月桂酰肌氨酸钠，同时开始均质搅拌，边脱气边进行均质。均质完成后加入5g薄荷油，在均质脱气数分钟完成制膏。
实施例3（以500g牙膏为基准）
取10g樟芝菌丝体粉；加入80g无水乙醇，在80~90℃下进行回流，每次1~1.5个小时，过滤，重复两次以上步骤，合并所得的滤液；在80~90℃下挥干乙醇即得樟芝菌丝体醇提液浓缩膏。将0.5g樟芝菌丝体醇提液浓缩膏和7.5g黄原胶预混于50g山梨醇中制得油相；把1.25g糖精钠和0.25g羟苯甲酯溶于去离子水中，然后投入余下的75g山梨醇制得水相；把150g和100g二水合磷酸氢钙和15g月桂酰肌氨酸钠混合制得固相；当制膏机真空度达到时，依次投入水相、油相，搅拌均质后加入固相，二次搅拌均质后加入10g留兰香精，均质数分钟完成制膏。
实施例4（以500g牙膏为基准）
取MEA平板上长好的樟芝菌块，经摇瓶种子制备、种子罐种子扩培、发酵罐发酵后，经固液分离，取上清液即得樟芝发酵上清液，用旋转真空浓缩法浓缩樟芝发酵上清液制得发酵上清液缩膏。将100g山梨醇和50g丙二醇、5g羧甲基纤维素钠和2.5g羟乙基纤维素、5g发酵上清液缩膏、1g糖精钠、0.25g苯甲酸钠和去离子水投入制膏机中，当锅内达到一定真空度后投入150g水合硅石、10g月桂酰肌氨酸钠，同时开始均质搅拌，边脱气边进行均质。均质完成后加入5g薄荷油，再均质脱气数分钟完成制膏。
实施例5（以500g牙膏为基准）
取MEA平板上长好的樟芝菌块，经摇瓶种子制备、种子罐种子扩培、发酵罐发酵后，经固液分离，取上清液即得樟芝发酵上清液，用旋转真空浓缩法浓缩樟芝发酵上清液制得发酵上清液浓缩膏。取5g樟芝菌丝体粉；加入25g无水乙醇，在80~90℃下进行回流，每次1~1.5个小时，过滤，重复两次以上步骤，合并所得的滤液；在80~90℃下挥干乙醇即得樟芝菌丝体醇提液浓缩膏。
取0.25g樟芝菌丝体醇提液浓缩膏、10g发酵上清液浓缩膏和10g羧甲基纤维素钠均匀分散于100g山梨醇和50g聚乙二醇中。然后将0.5 g糖精钠和0.5g羟苯甲酯溶解于适量的去离子水中；在强力搅拌下再将两种溶液混合使其膨胀成均匀的胶体。静置一定时间后，加入180g水合硅石、7.5g月桂酰肌氨酸钠和5g薄荷油于胶体中，充分搅拌均匀，最后加入去离子水配成500g。再研磨均质，真空脱气制成牙膏膏体。
试验例1
将本配方的中药添加物樟芝混入鼠粮中。实验分为3组，每组小鼠5只。樟芝的添加量依次为20g/kg 、30g/kg、45g/kg，长期给小白鼠喂食。喂养期间观察动物表情及精神都反应良好，血蛋白、血小板、红细胞、白细胞数均正常。三个月后解剖，发现只有最高剂量组的少数大鼠有轻微病变，而其他组的大鼠各器官和组织均异常或无其他病变。而本配方牙膏中樟芝的最大添加量为10g/kg，属于安全添加范围，可见该组方牙膏安全可靠，可长期使用。
试验例2
研究对象:
实验组：300人，患牙龈炎男女各50例，患口腔溃疡男女各50例、患牙齿敏感男女各50例，年龄在25-50岁。
对照组： 300人，患牙龈炎男女各50例，患口腔溃疡男女各50例、患牙齿敏感男女各50例，年龄在25-50岁。
使用方法:
实验组：使用樟芝牙膏；采用水平颤动法早晚刷牙2次，每次使用该牙膏2g；
对照组：使用不含任何药物成分和特殊功效的普通牙膏；采用水平颤动法早晚刷牙2次，每次使用该牙膏2g。
实验结果统计数据如图1和图2所示，可见实验组的牙病症状缓解迅速，有效率高，且无不良反应。而对照组使用普通牙膏的牙病症状缓解十分缓慢，而且时有复发。因此，本发明樟芝中药牙膏可用于预防和改善多种常见口腔疾病，安全有效。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。

Claims (10)

  1. 一种樟芝中药牙膏，其特征在于，按重量百分比计算，所述樟芝中药牙膏包括以下组分：樟芝浓缩膏为0.05-3%、摩擦剂20-50%、保湿剂20-30%、表面活性剂2-3%、增稠剂1-2%、甜味剂0.05-0.25%、防腐剂0.05-0.5%、香精1-2%，余量为水。
  2. 根据权利要求1所述的樟芝中药牙膏，其特征在于，所述樟芝浓缩膏为发酵上清液浓缩膏和/或樟芝菌丝体醇提液浓缩膏。
  3. 根据权利要求1所述的樟芝中药牙膏，其特征在于，所述摩擦剂为碳酸钙、二水合磷酸氢钙、焦磷酸钙、二氧化硅和氢氧化铝中的至少一种；所述保湿剂为甘油、山梨醇、丙二醇、聚乙二醇和水中的至少一种。
  4. 根据权利要求1所述的樟芝中药牙膏，其特征在于，所述表面活性剂为十二醇硫酸钠、甲基椰油酰基牛磺酸钠和月桂酰肌氨酸钠中的至少一种。
  5. 根据权利要求1所述的樟芝中药牙膏，其特征在于，所述增稠剂为羧甲基纤维素钠、鹿角果胶、羟乙基纤维素、黄原胶、瓜尔胶和卡拉胶中的至少一种。
  6. 根据权利要求1所述的樟芝中药牙膏，其特征在于，所述甜味剂为糖精、糖精钠、蔗糖、木糖醇和甜蜜素中的至少一种；所述防腐剂为山梨酸钾、苯甲酸钠、羟苯甲酯、羟苯乙酯和羟苯丙酯中的至少一种。
  7. 根据权利要求1所述的樟芝中药牙膏，其特征在于，所述香精为薄荷油、柠檬香油、留兰香油、橙油、桔子油、冬木油、丁香油、肉桂油、茴香油和龙脑中的至少一种。
  8. 根据权利要求1~7任意一项所述的樟芝中药牙膏的制备方法，其特征在于，包括以下步骤：提供樟芝浓缩膏；将所述樟芝浓缩膏与其他组分混合制成牙膏。
  9. 根据权利要求8所述的樟芝中药牙膏的制备方法，其特征在于，所述樟芝浓缩膏为樟芝菌丝体醇提液浓缩膏，其制备过程如下：取1重量份樟芝菌丝体；加入4-8重量份无水乙醇于80~90℃下回流1~1.5个小时，过滤，重复至少两次以上步骤，合并所得的滤液；将所述滤液在80~90℃下挥干乙醇即得樟芝菌丝体醇提液浓缩膏。
  10. 根据权利要求8所述的樟芝中药牙膏的制备方法，其特征在于，所述樟芝浓缩膏为发酵上清液浓缩膏，其制备过程如下：樟芝经深层液体发酵，固液分离后取上清液浓缩制得发酵上清液浓缩膏。
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