WO2015073509A8 - Biomarker for melk activity and methods of using same - Google Patents
Biomarker for melk activity and methods of using same Download PDFInfo
- Publication number
- WO2015073509A8 WO2015073509A8 PCT/US2014/065173 US2014065173W WO2015073509A8 WO 2015073509 A8 WO2015073509 A8 WO 2015073509A8 US 2014065173 W US2014065173 W US 2014065173W WO 2015073509 A8 WO2015073509 A8 WO 2015073509A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- biomarker
- melk
- same
- ortholog
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/034,955 US10254283B2 (en) | 2013-11-12 | 2014-11-12 | Biomarker for MELK activity and methods of using same |
EP14862279.8A EP3068930A4 (en) | 2013-11-12 | 2014-11-12 | Biomarker for melk activity and methods of using same |
AU2014348780A AU2014348780B2 (en) | 2013-11-12 | 2014-11-12 | Biomarker for MELK activity and methods of using same |
CN201480072848.3A CN106232878A (en) | 2013-11-12 | 2014-11-12 | The biomarker of MELK activity and the method that uses it |
CA2928464A CA2928464A1 (en) | 2013-11-12 | 2014-11-12 | Biomarker for melk activity and methods of using same |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361902877P | 2013-11-12 | 2013-11-12 | |
US61/902,877 | 2013-11-12 | ||
US201461954046P | 2014-03-17 | 2014-03-17 | |
US61/954,046 | 2014-03-17 | ||
US61/954,048 | 2014-03-17 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2015073509A2 WO2015073509A2 (en) | 2015-05-21 |
WO2015073509A3 WO2015073509A3 (en) | 2016-01-14 |
WO2015073509A8 true WO2015073509A8 (en) | 2016-05-26 |
Family
ID=55867713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/065173 WO2015073509A2 (en) | 2013-11-12 | 2014-11-12 | Biomarker for melk activity and methods of using same |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP3068930A4 (en) |
CN (1) | CN106232878A (en) |
AU (1) | AU2014348780B2 (en) |
CA (1) | CA2928464A1 (en) |
WO (1) | WO2015073509A2 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1651956A4 (en) * | 2003-08-14 | 2008-08-20 | Exelixis Inc | Melks as modifiers of the rac pathway and methods of use |
EP2574929A1 (en) * | 2011-09-28 | 2013-04-03 | IMG Institut für medizinische Genomforschung Planungsgesellschaft M.B.H. | Marker in diagnosing prostate cancer (PC) |
CN103173527A (en) * | 2011-12-22 | 2013-06-26 | 上海生物芯片有限公司 | Application of MELK gene |
KR101920109B1 (en) * | 2012-01-19 | 2018-11-19 | 온코세라피 사이언스 가부시키가이샤 | 1,5-naphthyridine derivatives and melk inhibitors containing the same |
-
2014
- 2014-11-12 CN CN201480072848.3A patent/CN106232878A/en active Pending
- 2014-11-12 AU AU2014348780A patent/AU2014348780B2/en not_active Ceased
- 2014-11-12 WO PCT/US2014/065173 patent/WO2015073509A2/en active Application Filing
- 2014-11-12 CA CA2928464A patent/CA2928464A1/en not_active Abandoned
- 2014-11-12 EP EP14862279.8A patent/EP3068930A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP3068930A2 (en) | 2016-09-21 |
AU2014348780A1 (en) | 2016-06-02 |
CN106232878A (en) | 2016-12-14 |
CA2928464A1 (en) | 2015-05-21 |
AU2014348780A8 (en) | 2016-06-30 |
WO2015073509A3 (en) | 2016-01-14 |
WO2015073509A2 (en) | 2015-05-21 |
AU2014348780B2 (en) | 2018-12-13 |
EP3068930A4 (en) | 2017-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TN2018000276A1 (en) | Inhibitors of receptor-interacting protein kinase 1. | |
IL254919B (en) | Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells, uses thereof, methods and kits relating to same | |
PH12016502177A1 (en) | Processes of preparing a jak1 inhibitor and new forms thereto | |
IL277006A (en) | Cd73 inhibitors | |
EP3760625C0 (en) | Bicyclic lactams as receptor-interacting protein-1 (rip1) kinase inhibitors for treating e.g. inflammatory diseases | |
WO2016055777A3 (en) | Modified enzymes | |
SG11202002192QA (en) | Restoration of t cell activity via the cd39/cd73 axis | |
IL304348A (en) | Cd73 inhibitors | |
NZ725917A (en) | Novel polymerase-i inhibitors, uses and methods for making them | |
MX2022010755A (en) | Kinase inhibitors and uses thereof. | |
ZA201802059B (en) | Assay for the diagnosis of dermatophytosis | |
WO2016079110A3 (en) | Use of enzyme for cleaning | |
MX2017008280A (en) | Process of making cenicriviroc and related analogs. | |
MA39824A (en) | Amido-substituted azole compounds as inhibitors of tnks1 and/or tnks2 | |
WO2015185672A3 (en) | New markers for the assessment of an increased risk for mortality | |
IL248567A0 (en) | Use of known compounds as d-amino acid oxidase inhibitors | |
WO2015022077A8 (en) | Novel anti-fc-gamma receptor iib antibodies and uses thereof | |
PH12016501326A1 (en) | (s)-3'-methyl-abscisic acid and esters thereof | |
WO2016069542A3 (en) | Lactone compounds and methods of making and using same | |
HRP20190286T1 (en) | Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine | |
EP3677263A4 (en) | Composition for decreasing serum uric acid level | |
MY188420A (en) | Crystalline forms of (s)-afoxolaner | |
EP3532044A4 (en) | Hdac inhibitor compositions for reactivation of the x chromosome | |
WO2015073509A8 (en) | Biomarker for melk activity and methods of using same | |
HUE063980T2 (en) | Combination of markers for predicting the response to vx-001 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14862279 Country of ref document: EP Kind code of ref document: A2 |
|
ENP | Entry into the national phase |
Ref document number: 2928464 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 15034955 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2014348780 Country of ref document: AU Date of ref document: 20141112 Kind code of ref document: A |
|
REEP | Request for entry into the european phase |
Ref document number: 2014862279 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2014862279 Country of ref document: EP |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14862279 Country of ref document: EP Kind code of ref document: A2 |