EP3068930A4 - Biomarker for melk activity and methods of using same - Google Patents
Biomarker for melk activity and methods of using same Download PDFInfo
- Publication number
- EP3068930A4 EP3068930A4 EP14862279.8A EP14862279A EP3068930A4 EP 3068930 A4 EP3068930 A4 EP 3068930A4 EP 14862279 A EP14862279 A EP 14862279A EP 3068930 A4 EP3068930 A4 EP 3068930A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- biomarker
- methods
- same
- melk activity
- melk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361902877P | 2013-11-12 | 2013-11-12 | |
US201461954046P | 2014-03-17 | 2014-03-17 | |
PCT/US2014/065173 WO2015073509A2 (en) | 2013-11-12 | 2014-11-12 | Biomarker for melk activity and methods of using same |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3068930A2 EP3068930A2 (en) | 2016-09-21 |
EP3068930A4 true EP3068930A4 (en) | 2017-10-04 |
Family
ID=55867713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14862279.8A Withdrawn EP3068930A4 (en) | 2013-11-12 | 2014-11-12 | Biomarker for melk activity and methods of using same |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP3068930A4 (en) |
CN (1) | CN106232878A (en) |
AU (1) | AU2014348780B2 (en) |
CA (1) | CA2928464A1 (en) |
WO (1) | WO2015073509A2 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013045539A1 (en) * | 2011-09-28 | 2013-04-04 | Img Institut Für Medizinische Genomforschung Planungsgesellschaft M.B.H. | Marker in diagnosing prostate cancer (pc) |
WO2013109388A2 (en) * | 2012-01-19 | 2013-07-25 | Oncotherapy Science, Inc. | 1,5-naphthyridine derivatives and melk inhibitors containing the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1651956A4 (en) * | 2003-08-14 | 2008-08-20 | Exelixis Inc | Melks as modifiers of the rac pathway and methods of use |
CN103173527A (en) * | 2011-12-22 | 2013-06-26 | 上海生物芯片有限公司 | Application of MELK gene |
-
2014
- 2014-11-12 CN CN201480072848.3A patent/CN106232878A/en active Pending
- 2014-11-12 AU AU2014348780A patent/AU2014348780B2/en not_active Ceased
- 2014-11-12 WO PCT/US2014/065173 patent/WO2015073509A2/en active Application Filing
- 2014-11-12 CA CA2928464A patent/CA2928464A1/en not_active Abandoned
- 2014-11-12 EP EP14862279.8A patent/EP3068930A4/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013045539A1 (en) * | 2011-09-28 | 2013-04-04 | Img Institut Für Medizinische Genomforschung Planungsgesellschaft M.B.H. | Marker in diagnosing prostate cancer (pc) |
WO2013109388A2 (en) * | 2012-01-19 | 2013-07-25 | Oncotherapy Science, Inc. | 1,5-naphthyridine derivatives and melk inhibitors containing the same |
Non-Patent Citations (6)
Title |
---|
I. NAKANO ET AL: "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway", NEURO-ONCOLOGY, vol. 13, no. 6, 9 May 2011 (2011-05-09), US, pages 622 - 634, XP055370701, ISSN: 1522-8517, DOI: 10.1093/neuonc/nor023 * |
NAKANO ICHIRO ET AL: "Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells", JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, US, vol. 86, no. 1, 1 January 2008 (2008-01-01), pages 48 - 60, XP002527172, ISSN: 0360-4012, [retrieved on 20070824], DOI: 10.1002/JNR.21471 * |
SUYOUN CHUNG ET AL: "Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.", ONCOTARGET JAN 2012, vol. 3, no. 12, 1 December 2012 (2012-12-01), pages 1629 - 1640, XP055115455, ISSN: 1949-2553, DOI: 10.18632/oncotarget.790 * |
SUYOUN CHUNG ET AL: "MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells", CELL CYCLE, vol. 12, no. 11, 1 June 2013 (2013-06-01), US, pages 1655 - 1656, XP055370762, ISSN: 1538-4101, DOI: 10.4161/cc.24988 * |
WENBIN JI ET AL: "OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases", PLOS ONE, vol. 11, no. 4, 15 April 2016 (2016-04-15), pages e0153518, XP055370874, DOI: 10.1371/journal.pone.0153518 * |
YUBAO WANG ET AL: "Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, vol. 113, no. 35, 15 August 2016 (2016-08-15), US, pages 9810 - 9815, XP055370320, ISSN: 0027-8424, DOI: 10.1073/pnas.1606862113 * |
Also Published As
Publication number | Publication date |
---|---|
EP3068930A2 (en) | 2016-09-21 |
AU2014348780A1 (en) | 2016-06-02 |
CN106232878A (en) | 2016-12-14 |
WO2015073509A8 (en) | 2016-05-26 |
CA2928464A1 (en) | 2015-05-21 |
AU2014348780A8 (en) | 2016-06-30 |
WO2015073509A3 (en) | 2016-01-14 |
WO2015073509A2 (en) | 2015-05-21 |
AU2014348780B2 (en) | 2018-12-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20160610 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/7088 20060101ALI20170516BHEP Ipc: G01N 33/574 20060101ALI20170516BHEP Ipc: C12N 15/113 20100101ALI20170516BHEP Ipc: C12N 9/12 20060101ALI20170516BHEP Ipc: C40B 20/00 20060101ALI20170516BHEP Ipc: G01N 33/573 20060101ALI20170516BHEP Ipc: A61K 38/12 20060101ALI20170516BHEP Ipc: C40B 30/08 20060101AFI20170516BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20170831 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/7088 20060101ALI20170825BHEP Ipc: G01N 33/574 20060101ALI20170825BHEP Ipc: C12N 15/113 20100101ALI20170825BHEP Ipc: C12N 9/12 20060101ALI20170825BHEP Ipc: G01N 33/573 20060101ALI20170825BHEP Ipc: C40B 20/00 20060101ALI20170825BHEP Ipc: C40B 30/08 20060101AFI20170825BHEP Ipc: A61K 38/12 20060101ALI20170825BHEP |
|
17Q | First examination report despatched |
Effective date: 20181112 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20191210 |