EP3068930A4 - Biomarker for melk activity and methods of using same - Google Patents

Biomarker for melk activity and methods of using same Download PDF

Info

Publication number
EP3068930A4
EP3068930A4 EP14862279.8A EP14862279A EP3068930A4 EP 3068930 A4 EP3068930 A4 EP 3068930A4 EP 14862279 A EP14862279 A EP 14862279A EP 3068930 A4 EP3068930 A4 EP 3068930A4
Authority
EP
European Patent Office
Prior art keywords
biomarker
methods
same
melk activity
melk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14862279.8A
Other languages
German (de)
French (fr)
Other versions
EP3068930A2 (en
Inventor
Jean Zhao
Yubao Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Publication of EP3068930A2 publication Critical patent/EP3068930A2/en
Publication of EP3068930A4 publication Critical patent/EP3068930A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP14862279.8A 2013-11-12 2014-11-12 Biomarker for melk activity and methods of using same Withdrawn EP3068930A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361902877P 2013-11-12 2013-11-12
US201461954046P 2014-03-17 2014-03-17
PCT/US2014/065173 WO2015073509A2 (en) 2013-11-12 2014-11-12 Biomarker for melk activity and methods of using same

Publications (2)

Publication Number Publication Date
EP3068930A2 EP3068930A2 (en) 2016-09-21
EP3068930A4 true EP3068930A4 (en) 2017-10-04

Family

ID=55867713

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14862279.8A Withdrawn EP3068930A4 (en) 2013-11-12 2014-11-12 Biomarker for melk activity and methods of using same

Country Status (5)

Country Link
EP (1) EP3068930A4 (en)
CN (1) CN106232878A (en)
AU (1) AU2014348780B2 (en)
CA (1) CA2928464A1 (en)
WO (1) WO2015073509A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013045539A1 (en) * 2011-09-28 2013-04-04 Img Institut Für Medizinische Genomforschung Planungsgesellschaft M.B.H. Marker in diagnosing prostate cancer (pc)
WO2013109388A2 (en) * 2012-01-19 2013-07-25 Oncotherapy Science, Inc. 1,5-naphthyridine derivatives and melk inhibitors containing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1651956A4 (en) * 2003-08-14 2008-08-20 Exelixis Inc Melks as modifiers of the rac pathway and methods of use
CN103173527A (en) * 2011-12-22 2013-06-26 上海生物芯片有限公司 Application of MELK gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013045539A1 (en) * 2011-09-28 2013-04-04 Img Institut Für Medizinische Genomforschung Planungsgesellschaft M.B.H. Marker in diagnosing prostate cancer (pc)
WO2013109388A2 (en) * 2012-01-19 2013-07-25 Oncotherapy Science, Inc. 1,5-naphthyridine derivatives and melk inhibitors containing the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
I. NAKANO ET AL: "Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway", NEURO-ONCOLOGY, vol. 13, no. 6, 9 May 2011 (2011-05-09), US, pages 622 - 634, XP055370701, ISSN: 1522-8517, DOI: 10.1093/neuonc/nor023 *
NAKANO ICHIRO ET AL: "Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells", JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, US, vol. 86, no. 1, 1 January 2008 (2008-01-01), pages 48 - 60, XP002527172, ISSN: 0360-4012, [retrieved on 20070824], DOI: 10.1002/JNR.21471 *
SUYOUN CHUNG ET AL: "Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.", ONCOTARGET JAN 2012, vol. 3, no. 12, 1 December 2012 (2012-12-01), pages 1629 - 1640, XP055115455, ISSN: 1949-2553, DOI: 10.18632/oncotarget.790 *
SUYOUN CHUNG ET AL: "MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells", CELL CYCLE, vol. 12, no. 11, 1 June 2013 (2013-06-01), US, pages 1655 - 1656, XP055370762, ISSN: 1538-4101, DOI: 10.4161/cc.24988 *
WENBIN JI ET AL: "OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases", PLOS ONE, vol. 11, no. 4, 15 April 2016 (2016-04-15), pages e0153518, XP055370874, DOI: 10.1371/journal.pone.0153518 *
YUBAO WANG ET AL: "Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, vol. 113, no. 35, 15 August 2016 (2016-08-15), US, pages 9810 - 9815, XP055370320, ISSN: 0027-8424, DOI: 10.1073/pnas.1606862113 *

Also Published As

Publication number Publication date
EP3068930A2 (en) 2016-09-21
AU2014348780A1 (en) 2016-06-02
CN106232878A (en) 2016-12-14
WO2015073509A8 (en) 2016-05-26
CA2928464A1 (en) 2015-05-21
AU2014348780A8 (en) 2016-06-30
WO2015073509A3 (en) 2016-01-14
WO2015073509A2 (en) 2015-05-21
AU2014348780B2 (en) 2018-12-13

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RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/7088 20060101ALI20170516BHEP

Ipc: G01N 33/574 20060101ALI20170516BHEP

Ipc: C12N 15/113 20100101ALI20170516BHEP

Ipc: C12N 9/12 20060101ALI20170516BHEP

Ipc: C40B 20/00 20060101ALI20170516BHEP

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Ipc: C12N 9/12 20060101ALI20170825BHEP

Ipc: G01N 33/573 20060101ALI20170825BHEP

Ipc: C40B 20/00 20060101ALI20170825BHEP

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