WO2014203911A1 - アプリケータ - Google Patents
アプリケータ Download PDFInfo
- Publication number
- WO2014203911A1 WO2014203911A1 PCT/JP2014/066070 JP2014066070W WO2014203911A1 WO 2014203911 A1 WO2014203911 A1 WO 2014203911A1 JP 2014066070 W JP2014066070 W JP 2014066070W WO 2014203911 A1 WO2014203911 A1 WO 2014203911A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- liner
- applicator
- sheet
- skin
- microneedle
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/002—Packages specially adapted therefor ; catheter kit packages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/0266—Holding devices, e.g. on the body using pads, patches, tapes or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Definitions
- One aspect of the present invention relates to an applicator used to assist administration of an active ingredient.
- a sheet member for administering an active ingredient through the skin is known.
- a patch described in Patent Document 1 below and a microneedle sheet as shown in FIG.
- An instrument for assisting the sticking of the sheet member is also known, and Patent Document 1 describes an assisting instrument for a patch.
- This auxiliary device includes a support having a larger surface than the patch, a pressure-sensitive adhesive applied to one side of the support, and a pressure-sensitive adhesive part that temporarily holds the patch in a peelable manner. A surface portion.
- microneedle sheet shown in FIG. 1 since a plurality of microneedles are formed along the main surface of the sheet, in order to puncture these microneedles into the skin, the microneedles are raised from the main surface. It is necessary to raise.
- An applicator is an applicator for applying a sheet member to the skin, and includes a main body having a bottom surface facing the skin, and a sheet member guided to a space between the skin and the bottom surface. The sheet member is applied to the skin after being folded in the space.
- the sheet member is guided between the skin and the bottom surface of the applicator, bent in the space, and applied to the skin.
- a mechanism that bends the sheet member in the space between the bottom surface of the applicator main body and the skin a plurality of types of sheet members can be appropriately applied to the skin.
- the release sheet is separated from the adhesive layer of the patch at the time of bending, and the adhesive layer can be applied to the skin.
- the microneedle sheet can be raised from the main surface of the sheet and applied to the skin at the time of bending.
- the applicator according to another aspect further includes a second guide portion, the first guide portion guides the sheet member provided on the liner to the space, and the second guide portion causes the liner to be outside the space. You may be guided to
- the main body may be a sheet.
- both the first and second guide portions may be slit-like holes.
- one end of the liner may be connected to one end of the main body.
- the first guide part may be the first edge part of the main body, and the second guide part may be the second edge part facing the first edge part.
- an auxiliary liner including a columnar member is attached to the liner, and the sheet member is attached to the auxiliary liner so that one end of the sheet member surrounds the columnar member. It may be bent by a cylindrical member in the space.
- an adhesive layer may be provided on at least a part of the bottom surface.
- At least a part of the bottom may be raised.
- the sheet member may be a microneedle sheet having a plurality of microneedles formed along the main surface of the sheet.
- a plurality of types of sheet members can be appropriately applied to the skin.
- FIG. 4 is a plan view corresponding to FIG. 3.
- FIG. 4 is a bottom view corresponding to FIG. 3.
- FIG. 4 is a front view (or rear view) corresponding to FIG. 3.
- FIG. 4 is a right side view (or left side view) corresponding to FIG. 3.
- the applicator 10 is an auxiliary device used when a sheet member for administering an arbitrary active ingredient (for example, a drug) into a living body is applied to the skin.
- the sheet member used with the applicator 10 and applied to the skin is not limited, and examples thereof include a patch and a microneedle sheet.
- an example in which the applicator 10 is used to apply the microneedle sheet to the skin will be described.
- the user can use the applicator 10 to puncture the microneedles into the skin with a more appropriate force than when the microneedle sheet is bent directly by hand.
- the microneedle sheet 20 used with the applicator 10 will be described.
- the microneedle sheet 20 has a strip shape and has a plurality of microneedles 22 formed on the sheet substantially along a main surface 21 of the sheet.
- These microneedles 22 are arranged so as to be aligned in the longitudinal direction and the width direction of the sheet, and the tips of all the microneedles 22 are directed to one end of the sheet (leftward in FIG. 1) without exception.
- the material of the microneedle sheet 20 and the microneedle 22 is not limited.
- the microneedle sheet 20 and the microneedle 22 are made of any of stainless steel, polyethylene terephthalate (PET), other metals, other resins, biodegradable materials, ceramics, or bioabsorbable materials. Good. Or you may produce the microneedle sheet
- PET polyethylene terephthalate
- the microneedle 22 can be formed by etching. If the sheet is a metal, the microneedle 22 can be formed by punching the sheet with a chemical solution, and if the sheet is non-metallic, the microneedle 22 can be formed by punching the sheet with a laser. In these cases, a void is generated around the microneedle 22. Of course, the microneedle 22 may be formed by a method other than etching. As shown in FIG. 1, in this embodiment, the microneedle 22 has a triangular shape, but the shape of the microneedle is not limited at all. In any case, since it is not necessary to raise the microneedle 22 from the main surface 21 of the sheet in advance, the microneedle sheet 20 can be easily and inexpensively manufactured.
- the dimensions of the microneedle sheet 20 are not limited. Specifically, the lower limit of the thickness may be 5 ⁇ m or 20 ⁇ m, and the upper limit of the thickness may be 1000 ⁇ m or 300 ⁇ m.
- the lower limit of the length may be 0.1 cm or 1 cm, and the upper limit of the length may be 50 cm or 20 cm.
- the lower limit of the width may be 0.1 cm or 1 cm, and the upper limit of the width may be 60 cm or 30 cm.
- the lower limit of the length and width of the microneedle sheet 20 is determined in consideration of the dose of the active ingredient, and the upper limit of the length and width is determined in consideration of the size of the living body.
- the parameters related to the microneedle 22 are not limited.
- the lower limit of the needle height may be 10 ⁇ m or 100 ⁇ m, and the upper limit of the height may be 10,000 ⁇ m or 1000 ⁇ m.
- the lower limit of the needle density may be 0.05 / cm 2 or 1 / cm 2
- the upper limit of the density may be 10,000 / cm 2 or 5000 / cm 2 .
- the lower limit of density is a value converted from the number and area of needles to which 1 mg of active ingredient can be administered
- the upper limit of density is a limit value in consideration of the shape of the needle.
- a preparation method of the active ingredient to be applied to the skin a method of coating the active ingredient on the microneedle sheet 20 itself, and an active ingredient is applied on the skin before the microneedle 22 is punctured into the skin.
- a technique and a technique of applying an active ingredient on the skin after puncturing the skin with the microneedle 22 are conceivable. If the active ingredient is coated on the microneedle sheet 20 in advance, it is preferable to apply a coating solution having a predetermined viscosity to the entire sheet with a uniform thickness as much as possible, but the microneedle 22 is along the main surface 21. Such application can be easily performed.
- the coating may be performed using the principle of screen printing, or may be performed by other methods. When a biodegradable sheet is used, the active ingredient can be included in the sheet itself.
- the liner 30 is used to set the microneedle sheet 20 on the applicator 10.
- the liner 30 is a belt-like sheet having a length and width larger than that of the microneedle sheet 20.
- the material of the liner 30 include plastics such as acrylic, but the material is not limited at all, and the liner 30 may be manufactured using, for example, metal or other types of resin.
- the microneedle sheet 20 is fixed to one end side of the liner 30 with a tape or an adhesive.
- the material of the liner 30 examples include plastics such as acrylic, but the material is not limited at all, and the liner 30 may be manufactured using, for example, metal or other types of resin. Although related figures show the liner 30 as being transparent or translucent, the liner 30 may be opaque.
- the applicator 10 is a rectangular sheet-like instrument.
- the side shown in FIG. 4 (plan view) is defined as the upper side of the applicator 10
- the side shown in FIG. 5 (bottom view) is defined as the lower side of the applicator 10.
- Appearance of the applicator 10 from the front and back is the same, and the appearance from both sides is also the same.
- FIG. 6 is a front view and a rear view of the applicator 10.
- FIG. 7 is a right side view and a left side view of the applicator 10.
- the main body 11 of the applicator 10 is formed with two slit-shaped through holes along a direction orthogonal to the longitudinal direction (hereinafter referred to as “width direction”).
- One through hole is a hole for guiding the liner 30 and the microneedle sheet 20 from the upper side to the lower side of the main body 11, and is hereinafter referred to as a first through hole 12.
- the other through hole is a hole for guiding the liner 30 peeled from the microneedle sheet 20 from the lower side to the upper side of the main body 11, and is hereinafter referred to as a second through hole 13.
- the distance between the two through holes 12 and 13 may be determined in consideration of the application range of the microneedle sheet 20 to the skin, or may be determined in consideration of other criteria.
- an adhesive (adhesive layer) 14 is provided on the bottom surface of the main body 11, in a rectangular shape so as to surround the two through holes 12 and 13.
- the adhesive 14 has a role of fixing the applicator 10 on the skin.
- the range of the adhesive 14 is not limited.
- the adhesive 14 may be provided only along both edges along the longitudinal direction of the main body 11, or may be provided only along both edges along the width direction of the main body 11.
- the material of the main body 11 examples include plastics such as acrylic, but the material is not limited at all, and the main body 11 may be manufactured using, for example, metal or other types of resin.
- the main body 11 is shown as a transparent or translucent object, but the main body 11 may be opaque.
- the dimensions of the applicator 10 may be determined according to the dimensions of the microneedle sheet 20 or the liner 30.
- the width of the applicator 10 may be determined according to the width of the liner 30.
- the total length (length along the longitudinal direction) of the applicator 10 may be determined in consideration of the length of the microneedle sheet 20 or the application range of the microneedle sheet 20 to the skin.
- the user sets the liner 30 to which the microneedle sheet 20 is attached to the applicator 10. Specifically, the user passes one end of the liner 30 to which the microneedle sheet 20 is not fixed from the top to the bottom through the first through hole 12, and the other end to the second through hole 13. From above. With this preparation, the liner 30 is positioned on the bottom surface side of the applicator 10 between the two through holes 12 and 13 as shown in FIG.
- the user pulls one end of the microneedle sheet 20 from the first through-hole 12 to the bottom surface side of the applicator 10 and bends it so that the one end is positioned below the adhesive 14 and maintains this state.
- Applicator 10 is applied to the application site of the active ingredient. By this series of operations, the applicator 10 is fixed on the skin S as shown in FIG.
- the user pulls one end of the liner 30 in the direction indicated by the arrow in FIG.
- the microneedle sheet 20 is guided by the liner 30, passes through the first through-hole 12, and enters the space between the skin S and the bottom surface of the applicator 10.
- the microneedle sheet 20 is bent 180 degrees in this space. Then, as shown in FIG. 10, the microneedle 22 located at the bent portion rises from the main surface 21, and the raised microneedle 22 pierces the skin S. When the user pulls the liner 30 until the entire liner 30 is pulled out from the applicator 10, the entire microneedle sheet 20 is applied to the skin as shown in FIG.
- the user can peel the applicator 10 from the skin after this.
- the user may peel off the microneedle sheet 20 immediately or may continue to apply the microneedle sheet 20 to the skin S for a predetermined time.
- the microneedle sheet 20 is fixed to the liner 30 with a tape or an adhesive, but the tape or adhesive can also be used to fix the microneedle sheet 20 on the skin. .
- microneedles 22 rising at a time between the applicator 10 and the skin S are one row along the width direction of the microneedle sheet 20.
- the angle formed between the raised microneedle 22 and the main surface 21 is larger than 0 degree and smaller than 180 degree.
- the puncture angle ⁇ (the angle formed between the microneedle 22 and the skin S) when the microneedle 22 rising from the main surface 21 pierces the skin is also greater than 0 degree and less than 180 degrees.
- the lower limit of the puncture angle may be 20 degrees, 34 degrees, or 40 degrees, and the upper limit of the angle may be 160 degrees, 140 degrees, or 100 degrees.
- the microneedle sheet 20 is guided between the skin and the bottom surface of the applicator 10, and the working surface of the sheet 20 (the surface on which the microneedle 22 rises). Is applied to the skin after being folded to face the outside of the arc.
- the applicator 10 can also be used for application of a patch.
- the user attaches the patch with the adhesive layer exposed to the liner 30.
- the patch may be attached to the liner 30 in advance.
- the liner 30 serves as a release sheet for the patch.
- the user passes the liner 30 through the two through holes 12 and 13 in the same manner as described above, fixes the applicator 10 on the skin, and pulls the liner 30.
- the patch is guided to the space between the skin and the bottom surface of the main body 11, and the adhesive layer (the working surface of the patch) is bent and attached to the skin so as to face the outside of the arc.
- the applicator 10 can appropriately apply a plurality of types of sheet members to the skin.
- the applicator 10 has a first through hole 12 that guides the liner with the sheet member to the skin surface, and a second through hole that guides the liner peeled from the sheet member to the outside of the applicator 10. 13.
- the main body 11 of the applicator 10 is a sheet, the dimension in the height direction is very small. Therefore, the applicator 10 is excellent in portability. In addition, even if the applicator 10 is fixed on the skin for a long time together with the sheet member, it can be said that the applicator 10 hardly disturbs the movement of the user or gives the user a sense of incongruity.
- the user can fix the applicator 10 on the skin without using another member such as a tape.
- the applicator 10 does not apply an impact to the microneedle sheet 20, but raises the microneedles 22 and pushes them into the skin to puncture the skins.
- the active ingredient can be administered without feeling.
- the microneedle 22 is in a state of extending substantially along the main surface 21 of the sheet. Therefore, as long as the applicator 10 is not used, there is no fear that the microneedle 22 hits or gets caught on another object (for example, a user's skin or clothes). As a result, safety when handling the microneedle 22 can be ensured. For example, the user can safely store and transport the microneedle sheet 20 and prepare immediately before use.
- the applicator 40 includes a rectangular main body portion 41 and a liner portion 42 connected to the main body portion 41 at one end in the longitudinal direction of the main body portion 41. Therefore, it can be said that the applicator 40 is obtained by integrating the applicator 10 and the liner 30 in the first embodiment.
- the structure of the main body 41 is the same as that of the applicator 10 in the first embodiment.
- the main body portion 41 is formed with two slit-like through holes formed along the width direction thereof.
- the through hole closer to the liner part 42 is a first through hole 43 for guiding the liner part 42 and the microneedle sheet 20 from the upper side to the lower side of the main body part 41.
- the other through-hole is a second through-hole 44 for guiding the liner part 42 peeled from the microneedle sheet 20 from the lower side to the upper side.
- an adhesive (adhesive layer) 45 is provided in a rectangular shape so as to surround the two through holes 43 and 44.
- the structure of the liner portion 42 is the same as that of the liner 30 in the first embodiment.
- the liner portion 42 has a sufficient length for applying the microneedle sheet 20 to the skin by a series of operations described later.
- the width of the liner portion 42 is smaller than the widths of the through holes 43 and 44. In the vicinity of the center of the upper surface of the liner portion 42, the microneedle sheet 20 is fixed with a tape or an adhesive as in the first embodiment.
- the user passes one end of the liner portion 42 to which the microneedle sheet 20 is attached from the top to the bottom through the first through-hole 43 and further passes the one end from the bottom to the top through the second through-hole 44.
- a part of the liner portion 42 is positioned on the bottom surface side of the applicator 40 between the two through holes 43 and 44.
- the subsequent operation method of the applicator 40 is the same as that of the first embodiment. That is, the user pulls one end of the microneedle sheet 20 from the first through-hole 43 to the bottom surface side of the applicator 40 and bends it so that the one end is positioned below the adhesive 45 and maintains this state. Attached to the application site of the active ingredient (similar to FIG. 9). Subsequently, the user pulls one end of the liner portion 42. By this operation, the microneedle sheet 20 guided in the space between the skin and the bottom surface of the applicator 40 is bent by 180 degrees, and the microneedle 22 positioned at the bent portion rises from the main surface 21 of the sheet. Then, the raised microneedle 22 pierces the skin S (similar to FIG. 10). The user pulls the liner portion 42 until the entire microneedle sheet 20 is applied to the skin (similar to FIG. 11).
- the sheet member such as the microneedle sheet 20 or the patch can be appropriately applied to the skin by the same mechanism as that of the first embodiment.
- the operation for applying the patch is as follows. First, the user attaches the patch with the adhesive layer exposed to the liner part 42. Alternatively, the patch may be attached to the liner portion 42 in advance. At this time, the liner portion 42 serves as a release sheet for the patch. Subsequently, the user passes the liner portion 42 through the two through holes 43 and 44 in the same manner as described above, fixes the applicator 40 on the skin, and pulls one end of the liner portion 42. By this operation, the patch is guided to the space between the skin and the bottom surface of the main body 41, and the adhesive layer (the working surface of the patch) is bent in the space so as to face the outside of the arc and is applied to the skin. Stick.
- the effect obtained by providing the two through holes 43 and 44, the effect obtained by making the applicator 40 into a sheet shape, and the effect obtained by providing the adhesive 45 are the same as in the first embodiment. It is. As in the first embodiment, the active ingredient can be administered without giving fear to the recipient.
- the main body portion 41 and the liner portion 42 are integrated. Therefore, if the user continues pulling the liner portion 42 even after the liner portion 42 is pulled and the microneedle sheet 20 is applied to the skin, the main body portion 41 is removed from the skin from the end connected to the liner portion 42. It begins to peel off. Therefore, the user can complete the application of the microneedle sheet 20 to the skin and the peeling of the applicator 40 from the skin by only one operation of pulling the liner portion 42.
- an adhesive 52 is provided along the entire edges along the longitudinal direction.
- the distance between the adhesives 52 provided at two locations is wider than the width of the liner 30.
- both edge portions of the main body 51 in the longitudinal direction function as first and second guide portions.
- the user can puncture the microneedle into the skin using the microneedle sheet 20 (similar to the first embodiment) fixed to the liner 30 and the applicator 50.
- the user arranges the liner 30 on the bottom surface side of the applicator 50 so that the portion of the liner 30 to which the microneedle sheet 20 is not fixed is located between the two adhesives 52. . Subsequently, the user bends one end of the microneedle sheet 20 and sticks the applicator 50 to the application site of the active ingredient while maintaining the state (similar to FIG. 9).
- the microneedle sheet 20 is drawn into the space, the microneedle sheet 20 is bent 180 degrees in the space, and the microneedle 22 positioned at the bent portion rises from the main surface 21 of the sheet.
- the raised microneedle 22 pierces the skin S (similar to FIG. 10).
- the applicator 50 can also be used to apply any sheet member.
- the operation for applying the patch is as follows. First, the user attaches the patch with the adhesive layer exposed to the liner 30. Alternatively, the patch may be attached to the liner 30 in advance. At this time, the liner 30 serves as a release sheet for the patch. Subsequently, the user arranges the liner 30 on the bottom side of the applicator 50 so that the liner 30 is positioned between the two adhesives 52 in the same manner as described above. Subsequently, the user bends one end of the patch and sticks the applicator 50 to the application site of the active ingredient while maintaining the state (similar to FIG. 9). Then, the user pulls one end of the liner 30. By this operation, the patch is guided to the space between the skin and the bottom surface of the main body 51, and the adhesive layer (the working surface of the patch) is bent and attached to the skin so as to face the outside of the arc.
- the main body of the applicator does not have to be a sheet, and the applicator may have an arbitrary height.
- the user can apply the microneedle sheet to the skin in the same manner as in the above embodiment after holding the applicator with a hand or the like, or applying the applicator to the skin with tape. Can do.
- At least one protrusion may be provided on the bottom surface of the main body of the applicator. This protrusion extends toward the skin, so the height of the space in the protrusion (the distance from the skin to the top of the protrusion) is the height of the space in the area where the protrusion is not provided (the distance from the skin to the bottom). ) Smaller.
- One or a plurality of protrusions are provided between the first guide part and the second guide part. Each protrusion may have a rail-like shape extending from the first guide portion to the second guide portion (that is, extending along the traveling direction of the sheet member).
- each protrusion may have a rail-like shape extending in parallel with the first and second guide portions (that is, extending in a direction orthogonal to the traveling direction of the sheet member).
- mountain-shaped or columnar protrusions may be formed two-dimensionally on the bottom surface.
- the “two-dimensional shape” means that a plurality of protrusions are formed along the direction extending from the first guide part to the second guide part, and in a direction parallel to the first and second guide parts. It means an aspect in which a plurality of protrusions are formed along.
- each protrusion may be different.
- the protrusions located on the inner side may be higher than the protrusions located on the outer side.
- the central portion of each protrusion may be higher than both ends of the protrusion.
- the protrusions positioned inside may be higher than the protrusions positioned outside.
- the portion located inside the main body is higher than the portion located outside the main body when viewed along the direction orthogonal to the traveling direction of the sheet member.
- Individual protrusions may be arranged or formed so as to be.
- the height of the space may be reduced by raising the entire bottom area between the first guide portion and the second guide portion, as in the case of providing the protrusion.
- forming a protrusion or raising the entire area of the bottom surface between the first guide portion and the second guide portion causes at least a portion of the bottom surface to protrude toward the skin. It is an example. Since the sheet member is pressed toward the skin in the space by raising at least a part of the bottom surface toward the skin in this way, the sheet member can be more reliably applied to the skin. For example, individual microneedles can be punctured into the skin more reliably.
- the method of providing a sheet member used with the applicators 10 and 50 is not limited to the above embodiment.
- a modification of the sheet member will be described with reference to FIGS.
- an auxiliary liner 60 is used in addition to the liner 30 similar to that of the first embodiment.
- the auxiliary liner 60 is a belt-like sheet having a width larger than that of the microneedle sheet 20 and includes a columnar member 61.
- the width may be the same as or smaller than the width of the microneedle sheet 20.
- the columnar member 61 is attached to one end in the longitudinal direction of the auxiliary liner 60 so as to extend along the width direction (direction orthogonal to the longitudinal direction) of the auxiliary liner 60. At this time, the columnar member 61 may be rotatably attached. Between the cylindrical member 61 and one end of the auxiliary liner 60, a slit-like hole 62 for allowing the microneedle sheet 20 to pass is formed.
- the material of the auxiliary liner 60 include plastics such as acrylic. However, the material is not limited at all, and the auxiliary liner 60 may be manufactured using, for example, metal or other types of resin.
- the material of the cylindrical member 61 may be metal, plastic such as acrylic, or other types of resin.
- the microneedle sheet 20 is fixed to one end side of the liner 30 with a tape or an adhesive as in the first embodiment.
- the auxiliary liner 60 is attached to the other end side of the liner 30 so that the columnar member 61 is connected to the microneedle sheet 20.
- the surface of the auxiliary liner 60 and the surface of the liner 30 may be fixed to each other with a tape or an adhesive, or the surfaces may not be fixed to each other.
- the microneedle sheet 20 is set with respect to the auxiliary liner 60 by passing one end of the microneedle sheet 20 located near the center of the liner 30 through the hole 62 and bending it 180 degrees so as to surround the cylindrical member 61. Is done.
- a method of using the microneedle sheet 20 (that is, the microneedle sheet 20 shown in FIG. 17) attached to the liner 30 and the auxiliary liner 60 together with the applicator 10 will be described.
- the user passes the auxiliary liner 60 through the first through-hole 12 from above, and further passes the auxiliary liner 60 through the second through-hole 13 from below.
- the auxiliary liner 60 is positioned on the bottom surface side of the applicator 10 between the two through holes 12 and 13 as shown in FIG. 18, and a part of the liner 30 is also positioned on the bottom surface side.
- the user places one end of the microneedle sheet 20 bent in the vicinity of the cylindrical member 61, for example, below the adhesive 14, and sticks the applicator 10 to the application site of the active ingredient while maintaining this state.
- the applicator 10 is fixed on the skin S by this series of operations.
- the cylindrical member 61 moves toward the second through hole 13
- the movement of the cylindrical member 61 causes the liner 30 and the microneedle sheet 20 to pass through the first through hole 12 and between the skin S and the main body 11. Enter the space between the bottom.
- the microneedle sheet 20 is bent 180 degrees by the cylindrical member 61 in this space.
- the liner 30 separated from the microneedle sheet 20 is guided out of the space from the second through hole 13.
- the entire microneedle sheet 20 is applied to the skin.
- the user can then remove the applicator 10 from the skin.
- the user may peel off the microneedle sheet 20 immediately or may continue to apply the microneedle sheet 20 to the skin S for a predetermined time.
- the aspect using the auxiliary liner 60 having the cylindrical member 61 is also applicable when an arbitrary sheet member is applied.
- the operation for applying the patch is as follows. First, the user attaches the patch with the adhesive layer exposed to the liner 30. Alternatively, the patch may be attached to the liner 30 in advance. At this time, the liner 30 serves as a release sheet for the patch. Subsequently, the user passes the auxiliary liner 60 through the two through holes 12 and 13 in the same manner as described above. Subsequently, the user places one end of the patch folded near the cylindrical member 61 below, for example, the adhesive 14, and sticks the applicator 10 to the application site of the active ingredient while maintaining this state. Then, the user pulls the auxiliary liner 60. By this operation, the patch is guided to the space between the skin and the bottom surface of the main body 11, and the columnar member 61 folds the adhesive layer (the surface of the patch) so that it faces the outside of the arc. Stick on.
- the microneedle sheet 20 shown in FIG. 17 can also be used together with the applicator 50. Also in this case, the user can apply the microneedle sheet 20 to the skin by pulling the auxiliary liner 60.
- the auxiliary liner 60 shown in FIG. 17 can be applied to the applicator 40 in the second embodiment.
- An applicator 40A which is a modified example is shown in FIG.
- the auxiliary liner 60 is attached to one end side of the liner portion 42 (the side not connected to the main body portion 41).
- the surface of the auxiliary liner 60 and the surface of the liner portion 42 may be fixed to each other with a tape, an adhesive, or the like, or the surfaces may not be fixed to each other.
- the method of attaching the microneedle sheet 20 to the auxiliary liner 60 is the same as the modification shown in FIG.
- the user passes the auxiliary liner 60 through the first through-hole 43 from above and further passes one end of the auxiliary liner 60 through the second through-hole 44 from below.
- the auxiliary liner 60 is positioned on the bottom surface side of the applicator 40A between the two through holes 43 and 44, and a part of the liner portion 42 is also positioned on the bottom surface side.
- the user places one end of the microneedle sheet 20 bent in the vicinity of the cylindrical member 61 below, for example, the adhesive 45, and sticks the applicator 40A to the application site of the active ingredient while maintaining this state.
- the applicator 40A is fixed on the skin S by this series of operations.
- the cylindrical member 61 moves toward the second through hole 44, and the movement of the cylindrical member 61 causes the liner portion 42 and the microneedle sheet 20 to pass through the first through hole 43 and the skin S and the main body portion. 41 enters the space between the bottom surface of 41.
- the microneedle sheet 20 is bent 180 degrees by the cylindrical member 61 in this space.
- the microneedle 22 located at the bent portion rises from the main surface 21, and the raised microneedle 22 pierces the skin S.
- the liner portion 42 separated from the microneedle sheet 20 is guided out of the space from the second through hole 44.
- the entire microneedle sheet 20 is applied to the skin.
- any sheet member can be applied using the applicator 40A.
- the operation for applying the patch is as follows. First, the user attaches the patch with the adhesive layer exposed to the liner part 42. Alternatively, the patch may be attached to the liner portion 42 in advance. At this time, the liner portion 42 serves as a release sheet for the patch. Subsequently, the user passes the auxiliary liner 60 through the two through holes 43 and 44 in the same manner as described above. Subsequently, the user places one end of the patch folded near the cylindrical member 61 below the adhesive 45, for example, and sticks the applicator 40A to the application site of the active ingredient while maintaining this state. Then, the user pulls the auxiliary liner 60. By this operation, the patch is guided to the space between the skin and the bottom surface of the main body 41, and the columnar member 61 is bent so that the adhesive layer (the working surface of the patch) faces the outside of the arc, Stick to the skin.
- the sheet member can be more easily and reliably bent in the space between the skin and the main body of the applicator.
- the applicator according to the present invention may be hard or soft.
- an applicator that partially bends during use such as the applicators 40 and 40A described above, at least a part of the applicator (for example, a liner portion) has a flexibility that can be bent.
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Abstract
Description
第1実施形態に係るアプリケータ10は、生体内に任意の活性成分(例えば薬剤)を投与するためのシート部材を皮膚に適用する際に用いる補助器具である。アプリケータ10と共に用いる、皮膚に適用するシート部材は限定されず、例えば貼付剤やマイクロニードル・シートなどが挙げられる。本実施形態では、マイクロニードル・シートを皮膚に適用するためにアプリケータ10を用いる例を説明する。以下に説明する例において、使用者はアプリケータ10を用いることで、手で直接マイクロニードル・シートを曲げる場合よりも適切な力でマイクロニードルを皮膚に穿刺することができる。
次に、第2実施形態に係るアプリケータ40の構造を説明する。以下では第1実施形態と異なる点について特に説明し、第1実施形態と同様の点については説明を省略する。
Claims (10)
- シート部材を皮膚に適用するためのアプリケータであって、
前記皮膚と向かい合う底面を備える本体と、
前記皮膚と前記底面との間の空間へ前記シート部材を案内する第1の案内部と
を備え、
前記シート部材が、前記空間において折り曲げられた後に前記皮膚に適用される、
アプリケータ。 - 第2の案内部を更に備え、
前記第1の案内部が、ライナーに設けられた前記シート部材を前記空間へ案内し、
前記第2の案内部が、前記ライナーを前記空間の外へ案内する、
請求項1に記載のアプリケータ。 - 前記本体がシート状である、
請求項2に記載のアプリケータ。 - 前記第1及び第2の案内部が共にスリット状の孔である、
請求項3に記載のアプリケータ。 - 前記ライナーの一端が前記本体の一端に接続している、
請求項2~4のいずれか一項に記載のアプリケータ。 - 前記第1の案内部が前記本体の第1の縁部であり、
前記第2の案内部が前記第1の縁部と向かい合う第2の縁部である、
請求項3に記載のアプリケータ。 - 円柱部材を備える補助ライナーが前記ライナーに取り付けられ、
前記シート部材の一端が前記円柱部材を包囲するように、該シート部材が前記補助ライナーに対して取り付けられ、
前記シート部材が、前記空間において前記円柱部材により折り曲げられる、
請求項2~6のいずれか一項に記載のアプリケータ。 - 前記底面の少なくとも一部に粘着層が設けられている、
請求項1~7のいずれか一項に記載のアプリケータ。 - 前記底面の少なくとも一部が***した、
請求項1~8のいずれか一項に記載のアプリケータ。 - 前記シート部材が、シートの主面に沿って形成された複数のマイクロニードルを有するマイクロニードル・シートである、
請求項1~9のいずれか一項に記載のアプリケータ。
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CN201480034452.XA CN105324147B (zh) | 2013-06-18 | 2014-06-17 | 施放器 |
JP2015522944A JP6038311B2 (ja) | 2013-06-18 | 2014-06-17 | アプリケータ |
US14/899,146 US9849272B2 (en) | 2013-06-18 | 2014-06-17 | Applicator |
EP14813654.2A EP3011992B1 (en) | 2013-06-18 | 2014-06-17 | Applicator |
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EP (1) | EP3011992B1 (ja) |
JP (1) | JP6038311B2 (ja) |
KR (1) | KR101751653B1 (ja) |
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US10407383B2 (en) | 2014-02-03 | 2019-09-10 | Basf Se | Cyclopentene and cyclopentadiene compounds for controlling invertebrate pests |
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US20160136405A1 (en) | 2016-05-19 |
EP3011992A4 (en) | 2017-03-15 |
JPWO2014203911A1 (ja) | 2017-02-23 |
CN105324147A (zh) | 2016-02-10 |
TW201521798A (zh) | 2015-06-16 |
KR20160017071A (ko) | 2016-02-15 |
KR101751653B1 (ko) | 2017-06-27 |
EP3011992A1 (en) | 2016-04-27 |
JP6038311B2 (ja) | 2016-12-07 |
US9849272B2 (en) | 2017-12-26 |
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