WO2014200191A1 - Raw ingredient compound for improving wrinkles or whitening-hydrophilic smectite clay minerals composite and functional cosmetic product containing raw ingredient compound for improving wrinkles or whitening-hydrophilic smectite clay minerals composite - Google Patents

Raw ingredient compound for improving wrinkles or whitening-hydrophilic smectite clay minerals composite and functional cosmetic product containing raw ingredient compound for improving wrinkles or whitening-hydrophilic smectite clay minerals composite Download PDF

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Publication number
WO2014200191A1
WO2014200191A1 PCT/KR2014/004244 KR2014004244W WO2014200191A1 WO 2014200191 A1 WO2014200191 A1 WO 2014200191A1 KR 2014004244 W KR2014004244 W KR 2014004244W WO 2014200191 A1 WO2014200191 A1 WO 2014200191A1
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WIPO (PCT)
Prior art keywords
whitening
smectite clay
functional
raw material
hydrophilic smectite
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PCT/KR2014/004244
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French (fr)
Korean (ko)
Inventor
공수성
홍원기
김동명
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한국콜마주식회사
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Publication of WO2014200191A1 publication Critical patent/WO2014200191A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention is a hydrophilic smectite clay mineral interlayer that can be included in the functional cosmetics to improve wrinkles or whitening to enhance the stability of the formulation by enhancing the stability of the functional raw material to enhance the stability of the functional material with low light-heat stability
  • the present invention relates to a functional composite substituted with a raw compound for wrinkle improvement or whitening, a method for preparing the same, and a functional cosmetic including a raw material compound-hydrophilic smectite clay mineral composite for wrinkle improvement or whitening.
  • 'Functional Cosmetics' is a product that has an extra character of cosmetics and medicines. It helps to actively solve problems such as wrinkles, blemishes, freckles, dead skin cells, and dry skins. It is a cosmetic that gives.
  • the legal definition of functional cosmetics can be broadly classified into three categories: products that help to whiten the skin, products that help to improve skin wrinkles, and products that help to burn the skin finely or report the skin from ultraviolet rays.
  • the whitening ingredients notified by the Korea Food and Drug Administration were the extracts of biloba (2%), arbutin (2%), ethylascorbyl ether (2%), oil-soluble licorice extract (0.05 Ascorbyl glucoside (2%), magnesium ascorbyl phosphate (3%), and the anti-wrinkle improvement components are retinol (2500 IU / g), retinyl palmitate (lOOOOIU / g). Adenosine (0.04%). There are 24 kinds of poly- urety dretinamide (0.2%), and 24 kinds of sunscreen notice ingredients are titanium oxide (25%) and zinc oxide (25%) . .
  • inorganic oxide sunscreen titanium oxide and zinc oxide are also called physical sunscreens, and form a film on the surface of the skin to reflect sunlight, which is less irritating and safe on the skin.
  • chemical sunscreen it absorbs UV rays into the skin to cause chemical reactions and decomposes, but it has good application and feel, but it has low light stability and needs to be reapplied over time.
  • Most organic sunscreens have many limitations in use as they can cause irritant contact dermatitis on sensitive skin.
  • the active ingredients used in functional cosmetics are mostly natural and synthetic organic substances that cause irritant contact dermatitis in sensitive skin . . It is easily destroyed by light or heat, and thus has problems such as deterioration of stability of the material itself and easy loss of inherent functions. Therefore, there are many limitations in actual use, which makes it difficult to commercialize.
  • Prior art 1 (R 10-2006-0081440 A) relates to a method for preparing a clay-amino acid complex using an intercalation reaction, and to preparing a clay-amino acid complex in which an amino acid is substituted between layers of clay using an intercalation reaction. It is about how to.
  • the clay-amino acid complex comprises a layered nanocomposite in which a layer composed of amino acids instead of Na + exists between the clay layer and the layer by an intercalation reaction in which Na + ions between the layers of swellable clay montmorillonite are replaced with amino acids.
  • the clay-amino acid complex inhibits the swelling of the swellable clay, such as Na-niotniorillonite, It has the effect of simultaneously moisturizing amino acids, supplying nutrients, and sebum adsorption of clay.
  • Prior art 2 (KR 10-2006-0123556 A) relates to a cosmetic composition for blocking ultraviolet rays containing a medium-porous inorganic composite powder carrying an organic metal oxide in the pores and an organic sunscreen, a metal such as titanium, zinc in the skeleton Medium pore inorganic composite powder having a wide range of ultraviolet (UV-A, B) blocking ability by supporting metal oxides such as cerium and iron in the pores of the element-substituted medium porous silica molecular sieve, and improving the usability and safety.
  • UV-A, B ultraviolet
  • the present invention relates to a sunscreen cosmetic composition having a high sunscreen synergistic effect by containing an organic sunscreen, which is widely used, and prior art 3 (KR 10-2009- 0059107 A) is a hollow fiber having an organic sunscreen.
  • the hollow spherical silica composite pigment carrying the organic sunscreen in the pores of the hollow spherical silica is prepared to minimize direct contact of the organic UV blocker to the skin, so it does not cause skin trouble and skin allergy, and has excellent UV blocking ability. Skin flammability.
  • the present invention relates to an excellent sunscreen composition having excellent sebum control function, skin tone correction effect function by light scattering, skin flaw cover effect, soft focus effect, and light feeling.
  • prior art 4 (KR 10-2007-0105488 A) relates to a method for producing a functional active substance-inorganic clay composite for cosmetics, wrinkle improvement.
  • a functional cosmetic composition including a moisturizing effect and a sunscreen function by a simple dry manufacturing method using a bio-friendly inorganic material
  • the capsule material prepared through this is a biological activity that the functional cosmetic composition has a source
  • the cosmetic functional active substance-inorganic clay composite prepared above is completely encapsulated in the inorganic clay by the method of dry preparation.
  • the functional composite of the hydrophilic smectite clay mineral layer is prepared by improving the wrinkles or replacing the whitening raw material, and manufacturing functional cosmetics including the same.
  • the present invention has been completed by discovering that it can keep a long time and enhance the stability of the formulation.
  • an object of the present invention is to provide a functional cosmetic comprising a wrinkle improving or whitening raw material compound-hydrophilic smectite clay mineral composite, a method for manufacturing the same and a wrinkle improving or whitening raw material compound-hydrophilic smectite clay mineral composite.
  • the present invention includes a raw material compound-hydrophilic smectite clay mineral composite for wrinkle improvement or whitening, and has a color difference value ( ⁇ ) after 48 hours when exposed to a light source of 765W / [n 2 in the 300-800 nm wavelength range. Provides excellent wrinkle improvement or whitening functional cosmetics that satisfy the light-thermal stability.
  • the raw material compound for improving wrinkles may include one or more selected from the group consisting of retinol, retinyl palmitate .. adenosine and polyethoxylatedretinamide.
  • the raw material for the whitening is the extract of the mulberry, arbutin, ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, It may be one or more selected from the group consisting of niacinamide , alpha-bisabolol and ascorbyl tetraisopalmitate.
  • the hydrophilic smectite clay mineral may be one or more selected from the group consisting of montmorillonite, bentonite and hectorite.
  • the raw material compound-hydrophilic smectite clay mineral composite for wrinkle improvement or whitening is 0.1-20% by weight of the raw material for wrinkle improvement or whitening? It may be included as 3 ⁇ 4.
  • the present invention provides a raw material compound for improving or whitening wrinkles in hydrophilic smectite clay minerals, and the use of intercalated functional complexes and functional cosmetics for wrinkle improvement or skin whitening of the functional complexes.
  • the raw material compound for improving wrinkles may include at least one selected from the group consisting of retinol, retinyl palmitate, adenosine, and polyeisiletidretinamide.
  • the raw material for the whitening is the extract of arborine arborin. It may include one or more selected from the group consisting of ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, niacinamide, alpha-bisabolic and ascorbyl triisopalmitate.
  • the hydrophilic smectite clay mineral may include one or more selected from the group consisting of montmorillonite, bentonite, and nuclear thorite.
  • the functional composite may include 0.1 to 20% by weight of the raw material compound for wrinkle improvement or whitening.
  • the functional composite includes a raw material for wrinkle improvement or whitening, and has a color difference value ( ⁇ ) of 1.0 or less after 48 hours exposure to a 765W / m 2 light source in the 300-800 nm wavelength range, so that the light-thermal stability is excellent. It can be used to manufacture cosmetics with wrinkle improvement or whitening effect.
  • Aqueous dispersion of hydrophilic smectite clay mineral Obtaining; (2) dissolving 0.05-0.5 parts by weight of the raw material compound for wrinkle improvement or whitening in 5.0-10.0 parts by weight of distilled water and 20.0-30.0 parts by weight of alcohol solvent: (3) the solution obtained in step (2) above ( Adding to the aqueous dispersion obtained in step 1) and mixing by stirring for 20-30 hours; (4) After centrifuging the mixture obtained in the step (3) at 12,000 ⁇ 16,000rpm, and then washed 3 to 6 times. It provides a method for producing a wrinkle-improving and whitening raw material-hydrophilic smectite interlayer composite comprising the step of -5 lyophilization at 40 ° C 65-80 hours.
  • Wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral complex of the present invention is included in the wrinkle improvement or whitening functional cosmetics to maintain the properties of the functional raw material by preventing the wrinkle improvement by light-heat or the modification of the whitening raw material, It is possible to enhance the stability of the formulation, and ultimately to provide wrinkle improvement or whitening raw materials with excellent light-thermal stability.
  • FIG. 1 is a diagram illustrating a process of preparing a functional complex by replacing a functional material between layers of layered clay minerals by an intercalation reaction.
  • Figure 2 is a graph showing the interlayer spacing depending on the content of the arbutin raw material whitening through X-ray diffraction pattern analysis.
  • Example 3 is a view showing the color change according to light-heat after applying Example 7 and Comparative Example 7 to the sunscreen formulation.
  • the raw material compound for improving or whitening wrinkles—hydrophilic smectite clay mineral complex ' is a functional product produced by substituting a raw material for wrinkle improvement or whitening between hydrophilic smectite clay mineral layers using an intercalation reaction. Means complex.
  • the term "smectite” is one of clay minerals, which means that it is produced by weathering a high-base companion rock.
  • the term “clay mineral” refers to a mineral composed of clay, which is a silicate mineral whose output state is mainly clay, and refers to a general term of earth minerals composed of extremely fine mineral particles.
  • intercalation refers to a phenomenon in which molecules, atoms, and ions are inserted between layers of a layered material, and the product of intercalation is called an interlayer compound.
  • the present invention includes an anti-wrinkle or whitening raw material compound-hydrophilic smectite clay mineral complex, and the color difference value ( ⁇ ) after 48 hours after irradiation with a light source of 765W / I11 2 in the 300-800 ⁇ wavelength band satisfies 1.0 or less. It provides a functional cosmetic having excellent light-heat stability.
  • the raw material compound for improving wrinkles may include at least one selected from the group consisting of retinol, retinyl palmitate, adenosine, and polyethoxylatediretinamide.
  • Raw material for whitening Arbutin, ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, niacinamide, alpha-bisabo and ascorbyl tetraaspalmitate.
  • the raw material compound for improving wrinkles or whitening is a component notified by the Food and Drug Administration, and because it is an organic material, it may mean a raw material that has a property of being easily denatured by light or heat to degrade stability and easily lose its own function. .
  • the wrinkle improving raw material or whitening raw material may be used alone, the raw material may be mixed.
  • a hydrophilic smectite clay mineral may be used in the raw material compound-hydrophilic smectite clay mineral complex for improving wrinkles or whitening, and specific examples thereof include montmorillonite bentonite and hackiteite. Intercalation of the active material is useful because the use of one or more selected species with water leads to easy intercalation between several A and several tens A.
  • the raw material compound for improving wrinkles or whitening-hydrophilic smectite clay mineral complex may include 0.1-20% by weight of the raw material compound for improving wrinkles or whitening. When the content of wrinkle improvement and whitening raw materials in the functional composite is less than 0.1%, it is not suitable for cosmetic applications, and it is difficult to apply more than 20% by weight.
  • the raw material compound-hydrophilic smectite clay mineral complex for wrinkle improvement or whitening may be applied according to the published content of the Food and Drug Administration for wrinkle improvement or whitening source compound in cosmetics.
  • the functional cosmetics having excellent light-thermal stability may satisfy a color difference value ⁇ of 1.0 or less after 48 hours after irradiation with a light source. It means that the color difference has occurred greatly, and it can be seen that the wrinkle improvement or whitening raw material compound added is modified.
  • the present invention provides a functional complex in which the wrinkle-improving and whitening raw material is intercalated in a hydrophilic smectite clay mineral.
  • Wrinkle improvement and whitening raw material-hydrophilic smectite interlayer composite production method (1) 0.1-1.0 parts by weight of hydrophilic smectite clay mineral is added to 50.0-70.0 parts by weight of distilled water 1,000 in a homomixer After dispersing at 5,000 rpm, stirring at 20-30 ° C.
  • aqueous dispersion of hydrophilic smectite clay mineral (2) dissolving 0.05 to 0.5 parts by weight of the raw material compound for wrinkle improvement or whitening, 5.0-10.0 parts by weight of distilled water and 20.0 30.0 parts by weight of alcohol solvent; (3) adding the solution obtained in step (2) to the aqueous dispersion obtained in step (1) and mixing the mixture by stirring for 2 hours (K30 hours; (4) mixing the mixture obtained in step (3) in the range of 12,000 to After centrifugation at 16,000rpm, washed 3 to 6 times, freeze-dried at -5 to 40 ° C for 65 to 80 hours.
  • hydrophilic smectite to stir at 20-30 ° C for 24 to 30 hours It is preferable because it effectively advances primary swelling of the clay mineral.
  • the primary swelling is caused by water, which is due to the characteristics of the clay minerals, not a separate chemical reaction. If the stage of the homo mixer is less than 100 rpm, the dispersibility of the hydrophilic smectite clay mineral is inferior, and if it exceeds SOOO rpm, the interlayer swelling due to the interlayer swelling is collapsed.
  • the primary swelling is completed only when stirring for 24 hours or more.
  • the raw material compound for wrinkle improvement or whitening is effectively substituted.
  • ion exchange is more efficient than chemical reaction.
  • agitation should be performed for 20 hours or more to effectively replace wrinkles or whitening raw materials.
  • Hectorite (product name: BENT0NE EW, purchased from Elementis special ties (USA)) was used as a hydrophilic smectite clay mineral. Hectorite is a material having an interlaminar structure, which forms an independent plate-like structure of a sandwich structure including each metal oxide, and its chemical name is Na 0 . 33 [Mg 2.67 Li 0 . 33 ] Si 4 0 10 [OH] 2 , thin and long, with trioctahederal crystals, capable of capturing up to 35 times water.
  • the heterogeneous exchange capacity of the Hectorite clay mineral is a clay mineral with 50 meq / 100g or more, and has hydrophilic properties without surface modification. In case of having hydrophobic characteristics, BENTONE EW having hydrophilic characteristics was directly used because it is not suitable for industrial use because surface charge modification should be performed using basic materials.
  • a whitening raw material arbutin was used as an anti-wrinkle or whitening raw material compound, and the arbutin was a whitening functional raw material of the KFDA.
  • the chemical name was (2R, 3S, 4S, 5R, 6S) -2-Hydroxymethy 6-. (4-hydroxyphenoxy) oxane-3, 4, 5-tr iol. SHUIZHOUARTEC products were used.
  • the wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite of the present invention was prepared as follows based on the blending amount of Table 1 below.
  • Haktorite clay mineral was added to distilled water and dispersed at .2., 000rpm with a homomixer, followed by stirring at 25 ° C. for 24 hours to obtain an aqueous dispersion of nucleite clay mineral.
  • step 2) The solution of step 2) was added to the aqueous dispersion of step 1), followed by stirring for 24 hours to mix.
  • step 4) The mixture of step 3) was centrifuged with M.OOrpm, washed three times, and lyophilized at -45 ° C for 72 hours under 5iii torr conditions.
  • the raw material composition of the wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite is shown in Table 1 below.
  • Comparative Example 1 Wrinkle improvement or whitening raw material compound-drying hydrophilic smectite clay mineral composite by dry process (see patent application KR 10-2007-0105488 described method)
  • Arbutin, distilled water and ethanol were added to Hectorite clay minerals as shown in the following composition, mixed, and then mixed in an agate mortar (mold bowl) for 60 minutes at room temperature, followed by heat treatment at 60 ° C. for 2 hours to encapsulate. It was.
  • the layered structure analysis of the wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite prepared from Examples 1 to 6 and Comparative Examples 1 to 6 was performed using an X-ray analyzer, and the X-powder diffraction pattern was Cu-Ka. Rigaku diffractometer (D / M-2200 horr) using ⁇ 10 ⁇ wavelength: 0.15403 ⁇ 4111) as a light source was used.
  • Table 3 and Table 4 show the interlayer spacing of the functional complex according to the content of arbutin through the X-ray diffraction pattern analysis.
  • the control shows the interlayer spacing of smectite clay mineral complexes not treated with arbutin.
  • Example 3-6 having an arbutine added amount of 20 parts by weight or more relative to 100 parts by weight of hacklite was 14.9 A, considering that the initial lattice thickness of the hackite clay mineral was 10.7 A.
  • arbutin a whitening material
  • the distance between the layers of the arbutin was increased to increase the amount of arbutin.
  • the amount of arbutin intercalated into the clay mineral layer increases.
  • Example 2 is a graph showing the interlayer spacing 'according to the content of arbutin through the X-ray diffraction pattern analysis. As shown in the graph of FIG. 2, the method using the hydration-swelling of the clay mineral of nuclear lightite shows that the amount of arbutin added to 20 parts by weight based on 100 parts by weight of the nuclear light of Example 3 can be effectively intercalated.
  • Experimental Example 2 Denaturation test by light-heat irradiation
  • the denaturation test according to the heat-light of the present invention after applying the sunscreen formulation to wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral complex It measured using the pretest machine. The amount of the complex added was used in an amount such that the arbutin content was 2.0% by weight in the sunscreen formulation.
  • Suntest CPS + of ATLAS Co., Ltd. was used. The internal temperature of 40 ° C. and Xenon lamp were used to compare the light source of 765W / m 2 in the wavelength range of 300-800 ⁇ for 48 hours. This is equivalent to giving the same effect as 12 days of exposure in daylight. After 48 hours of irradiation, color difference ( ⁇ ) after 48 hours was analyzed. The degree of color difference is 0 0.5 almost no color difference, 0.6-1.0 feels very little color difference, 1.1 1.5-color difference is common but commonly used, 1.6 2.0 is large color difference.
  • composition of the sunscreen formulation is shown in Table 5 (unit: weight 3 ⁇ 4).
  • the functional cosmetics of the present invention can be confirmed that the excellent light-thermal stability.
  • the composite of the wrinkle improvement or whitening raw material compound of the present invention and the hydrophilic smectite clay mineral combine to improve the properties of the functional raw material and enhance the stability of the formulation since it prevents light-heating and improves the whitening raw material. It can be used to produce cosmetics having wrinkle improvement or whitening effect, and thus has high industrial applicability.

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Abstract

The present invention relates to a raw ingredient compound for improving wrinkles or whitening-hydrophilic smectite clay minerals composite, a use thereof and a preparation method therefor. By preparing a functional composite in which a raw ingredient compound for improving wrinkles or whitening is substituted between layers of hydrophilic smectite clay minerals by using intercalation, degeneration of the raw ingredient for improving wrinkles or whitening, which has low photo-thermal stability, is prevented, thereby maintaining the characteristics of functional ingredients for a long time and enhancing stability. Also, when a functional cosmetic product containing the raw ingredient compound for improving wrinkles or whitening-hydrophilic smectite clay minerals composite is manufactured, the functional cosmetic product can be manufactured to have excellent photo-thermal stability and a color difference value (ΔΕ) which is no more than 1.0, after 48 hours from an irradiation of a light source.

Description

【명세세  [Specifications
【발명의 명칭】  [Name of invention]
주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체, 그 제조방법 및 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체를 포함하는 기능성 화장품 Wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite, preparation method thereof and functional cosmetic including wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral complex
【기술분야】 Technical Field
본 발명은 주름 개선 또는 미백 기능성 화장품에 포함되어 광-열 안정성이 낮은 기능성 원료의 안정성을 강화시켜 기능성 원료의 특성을 오래 유지시킬 수 있도록 하여 제형의 안정성을 강화시킬 수 있는 친수계 스멕타이트 점토광물 층간에 주름 개선 또는 미백을 위한 원료 화합물이 치환된 기능성 복합체, 그 제조방법 및 주름 개선 또는 미백을 위한 원료 화합물-친수계 스멕타이트 점토광물 복합체를 포함하는 기능성 화장품에 관한 것이다. The present invention is a hydrophilic smectite clay mineral interlayer that can be included in the functional cosmetics to improve wrinkles or whitening to enhance the stability of the formulation by enhancing the stability of the functional raw material to enhance the stability of the functional material with low light-heat stability The present invention relates to a functional composite substituted with a raw compound for wrinkle improvement or whitening, a method for preparing the same, and a functional cosmetic including a raw material compound-hydrophilic smectite clay mineral composite for wrinkle improvement or whitening.
【배경기술】 Background Art
최근 건강하고 여유로운 삶이 요구되고 있는 가운데 아름다워지고자 하는 소비자의 욕구가 증가함에 따라 기능성 화장품에 관한 관심이 더욱 높아지고 있다. 그에 따라 피부 미화, 청결 등의 단순한 효능에서 고기능성, 다기능성을 함유한 미백， 주름 개선 및 자외선 차단 등 기능성 화장품 신소재 개발이 강하게 요구되고 있다. 이렇게 날로 다양화， 다변화， 고급화되는 소비자의 기호에 부응하기 위하여 탄생한 것이 바로 기능성 화장품이다. With the recent demand for a healthy and leisurely life, the interest in functional cosmetics is increasing as consumers' desire to be beautiful increases. Accordingly, there is a strong demand for the development of new functional cosmetic materials such as whitening, wrinkle improvement and sun protection, which contain high functionality and versatility, from simple effects such as skin beautification and cleanliness. Functional cosmetics were born to meet the tastes of consumers who are diversified, diversified and advanced.
'기능성 화장품' 이란 화장품과 의약품의 증간적인 성격을 가지는 제품으로 이전의 단순한 피부 보습， 피부 보호의 차원에서 벗어나 피부의 주름， 기미， 주근깨 , 죽는 각질 , 피부 건조 등과 같은 문제점들을 적극적으로 해결하는데 도움을 주는 화장품이다. 기능성 화장품의 법적 정의는 피부 미백에 도움을 주는 제품, 피부 주름 개선에 도움을 주는 제품 및 피부를 곱게 태워주거나 자외선으로부터 피부를 보고하는데 도움을 주는 제품으로 크게 3 가지로 분류할 수 있다. 식품 의약품 안전청에서 고시한 미백 성분은 닥나무추출물 (2%), 알부틴 (2%)， 에칠아스코빌에텔 (2%), 유용성감초추출물 (0.05«, 아스코빌글루코사이드 (2%), 마그네슘아스코빌포스페이트 (3%)가 있고， 주름개선 고시 성분은 레티놀 (2500IU/g), 레티닐팔미테이트 (lOOOOIU/g) . 아데노신 (0.04%). 폴리에특실레이티드레틴아마이드 (0.2%)가 있으며, 자외선 차단제 고시 성분은 24 가지로 티타늄옥사이드 (25%), 징크옥사이드 (25%).. 글리세릴파바 (Ο.δ- ο), 드로메트리졸 (0.5-7%). 디갈로일트리올레이트 (0.5~5%) 등이 있디-. 상기 자외선 차단제 고시 성분 중에서 무기 자외선 차단제 성분인 티타늄옥사이드 및 징크옥사이드의 경우에는 물리적 자외선 차단제라고도 하며, 피부 표면에 막을 형성하여 햇빛을 반사시키는 원리로 피부에 자극이 적고 안전하나， 유기 자외선 차단제 성분은 화학적 자외선 차단제라고도 하며, 자외선을 피부에 흡수하여 화학적인 반응을 일으키며 분해하는 원리로 발림성과 사용감이 좋지만 광 안정성이 낮아 시간이 지나면 다시 덧발라주어야 하고 피부에 흡수되어 자체가 자극을 일으키거나 광반응에 의한 생성물로 인하여 민감한 피부에는 자극성 접촉 피부염을 일으킬 수 있으므로 대부분의 유기 자외선 차단제는 사용에 있어서 많은 제약을 가지고 있다. 'Functional Cosmetics' is a product that has an extra character of cosmetics and medicines. It helps to actively solve problems such as wrinkles, blemishes, freckles, dead skin cells, and dry skins. It is a cosmetic that gives. The legal definition of functional cosmetics can be broadly classified into three categories: products that help to whiten the skin, products that help to improve skin wrinkles, and products that help to burn the skin finely or report the skin from ultraviolet rays. The whitening ingredients notified by the Korea Food and Drug Administration were the extracts of biloba (2%), arbutin (2%), ethylascorbyl ether (2%), oil-soluble licorice extract (0.05 Ascorbyl glucoside (2%), magnesium ascorbyl phosphate (3%), and the anti-wrinkle improvement components are retinol (2500 IU / g), retinyl palmitate (lOOOOIU / g). Adenosine (0.04%). There are 24 kinds of poly- urety dretinamide (0.2%), and 24 kinds of sunscreen notice ingredients are titanium oxide (25%) and zinc oxide (25%) . . Glyceryl pava (Ο.δ- ο), drometrizol (0.5-7%). Digaloyl trioleate (0.5 ~ 5%). Among the sunscreen notice ingredients, inorganic oxide sunscreen titanium oxide and zinc oxide are also called physical sunscreens, and form a film on the surface of the skin to reflect sunlight, which is less irritating and safe on the skin. Also known as chemical sunscreen, it absorbs UV rays into the skin to cause chemical reactions and decomposes, but it has good application and feel, but it has low light stability and needs to be reapplied over time. Most organic sunscreens have many limitations in use as they can cause irritant contact dermatitis on sensitive skin.
따라서 무기 자외선 차단제를 제외한 기능성 화장품에 사용되는 활성 성분은 대부분이 천연 및 합성 유기물로써 민감한 피ᅳ부에서 자극성 접촉 피부염을 일으키며 .. 광 또는 열에 의해 쉽게 파괴되어 물질 자체의 안정성 저하 및 고유의 기능을 쉽게 잃어버리는 등의 문제를 갖고 있어 실제 사용하는데 많은 제약이 있었으며 이로 인해 제품화에 어려움이 있었다. Therefore, the active ingredients used in functional cosmetics, except inorganic sunscreens, are mostly natural and synthetic organic substances that cause irritant contact dermatitis in sensitive skin . . It is easily destroyed by light or heat, and thus has problems such as deterioration of stability of the material itself and easy loss of inherent functions. Therefore, there are many limitations in actual use, which makes it difficult to commercialize.
상기와 같이 기능성 화장품에 사용되는 활성 성분의 안정성에 대한 문제점을 해결하기 위해 많은 기술이 보고되고 있다. 선행기술 1( R 10-2006-0081440 A)은 층간삽입 반응을 이용한 점토-아미노산 복합체의 제조 방법에 관한 것으로서， 인터칼레이션 반응올 이용하여 점토의 층간에 아미노산이 치환된 점토-아미노산 복합체를 제조하는 방법에 관한 것이다. 본 발명에 따르면， 점토-아미노산 복합체는 팽윤성 점토인 몬모릴로나이트의 층간의 Na+이온을 아미노산으로 치환하는 인터칼레이션 반응에 의하여 점토의 층과 층 사이에 Na+ 대신 아미노산으로 구성된 층이 존재하는 층상나노복합체를 제공함으로써， 상기 점토- 아미노산 복합체는 Na-niotniorillonite 와 같은 팽윤성 점토의 팽윤성을 억제하여， 아미노산의 보습， 영양공급 기능과 점토의 피지 흡착능 등을 동시에 갖는 효과가 있다. As described above, many techniques have been reported to solve the problem of the stability of the active ingredient used in functional cosmetics. Prior art 1 (R 10-2006-0081440 A) relates to a method for preparing a clay-amino acid complex using an intercalation reaction, and to preparing a clay-amino acid complex in which an amino acid is substituted between layers of clay using an intercalation reaction. It is about how to. According to the present invention, the clay-amino acid complex comprises a layered nanocomposite in which a layer composed of amino acids instead of Na + exists between the clay layer and the layer by an intercalation reaction in which Na + ions between the layers of swellable clay montmorillonite are replaced with amino acids. By providing the clay-amino acid complex inhibits the swelling of the swellable clay, such as Na-niotniorillonite, It has the effect of simultaneously moisturizing amino acids, supplying nutrients, and sebum adsorption of clay.
또한, 유기 자외선 차단제 분야에 있어서는 중공성 파우더 및 표면 개질을 이용한 다양한 안정화 기술에 대한 보고가 있다. 선행기술 2(KR 10-2006-0123556 A)는 기공내 금속산화물을 담지한 중형기공성 무기 복합분체와 유기계 자외선 차단제를 함유한 자외선 차단용 화장료 조성물에 관한 것으로, 골격 내에 티타늄, 아연 등의 금속원소가 치환된 중형기공성 실리카 분자체의 기공 내에 세륨， 철 등의 금속산화물올 담지함으로써 넓은 영역의 자외선 (UV-A, B) 차단능을 가지며, 사용감과 안전성이 향상된 중형 기공성 무기 복합분체와 보편적으로 널리 사용되는 유기계 자외선 차단제를 함유함으로써 높은 자외선 차단 상승 효과가 있는 자외선 차단용 화장료 초성물에 관한 것이고， 선행기술 3(KR 10-2009- 0059107 A)은 유기 자외선 차단제가 담지된 중공성 구형 실리카 복합안료의 제조방법 및 이를 함유한 자외선 차단용 화장료 조성물에 관한 것으로서. 중공성 구형 실리카의 기공 내에 상기 유기 자외선 차단제를 담지한 중공성 구형 실리카 복합 안료를 제조하여 상기 유기자외선 차단제의 피부로의 직접 접촉을 최소화하므로 피부 트러블과 피부 알러지를 유발하지 않고, 자외선 차단능이 우수하고， 피부 전연성. 우수한 피지컨트를 기능, 빛 산란에 의한 피부 톤 보정 효과 기능， 피부 결점 커버 효과, 소프트 포커스 효과, 가벼운 사용감을 갖는 특성이 현저한 자외선 차단제 조성물에 관한 것이다. In addition, in the field of organic sunscreens, there are reports of various stabilization techniques using hollow powders and surface modifications. Prior art 2 (KR 10-2006-0123556 A) relates to a cosmetic composition for blocking ultraviolet rays containing a medium-porous inorganic composite powder carrying an organic metal oxide in the pores and an organic sunscreen, a metal such as titanium, zinc in the skeleton Medium pore inorganic composite powder having a wide range of ultraviolet (UV-A, B) blocking ability by supporting metal oxides such as cerium and iron in the pores of the element-substituted medium porous silica molecular sieve, and improving the usability and safety. The present invention relates to a sunscreen cosmetic composition having a high sunscreen synergistic effect by containing an organic sunscreen, which is widely used, and prior art 3 (KR 10-2009- 0059107 A) is a hollow fiber having an organic sunscreen. A method for preparing a spherical silica composite pigment, and a cosmetic composition for blocking UV rays containing the same. The hollow spherical silica composite pigment carrying the organic sunscreen in the pores of the hollow spherical silica is prepared to minimize direct contact of the organic UV blocker to the skin, so it does not cause skin trouble and skin allergy, and has excellent UV blocking ability. Skin flammability. The present invention relates to an excellent sunscreen composition having excellent sebum control function, skin tone correction effect function by light scattering, skin flaw cover effect, soft focus effect, and light feeling.
또한， 선행기술 4(KR 10-2007-0105488 A)는 화장품용 기능성 활성 물질 -무기 점토 복합체의 제조방법에 관한 것으로서， 주름 개선. 보습 효과 및 자외선 차단 기능 등을 포함하는 기능성 화장품 조성물을 생체 친화적인 무기물을 이용하여 간단한 건식 제조 방법에 의하여 캡슐화 하는 공정을 포함하며, 이를 통해 제조된 캡슐 물질은 기능성 화장품 조성물이 원천적으로 갖는 생리활성 특성 이외에도 무기물의 캡슬화를 통해 화장품 조성물의 안정성, 안전성， 서방성, 피부 노폐물 제거 효과 등을 특징으로 갖는다. 하지만 상기로부터 제조된 화장품용 기능성 활성 물질—무기 점토 복합체는 건식 제조에 의한 방법으로 화장품용 기능성 활성 물질이 무기 점토에 완전하게 캡슐화 되었다고 단정을 짓기 어렵다. 본 명세서 전체에 걸쳐 다수의 논문 및 특허문헌이 참조되고 그 인용이 표시되어 있다. 인용된 논문 및 특허문헌의 개시 내용은 그 전체로서 본 명세서에 참조로 삽입되어 본 발명이 속하는 기술 분야의 수준 및 본 발명의 내용이 보다 명확하게 설명된다. 【발명의 내용】 In addition, prior art 4 (KR 10-2007-0105488 A) relates to a method for producing a functional active substance-inorganic clay composite for cosmetics, wrinkle improvement. Encapsulating a functional cosmetic composition including a moisturizing effect and a sunscreen function by a simple dry manufacturing method using a bio-friendly inorganic material, the capsule material prepared through this is a biological activity that the functional cosmetic composition has a source In addition to the characteristics of the inorganic material through the encapsulation of the stability, safety, sustained release, it is characterized by the effect of removing skin waste. However, it is difficult to conclude that the cosmetic functional active substance-inorganic clay composite prepared above is completely encapsulated in the inorganic clay by the method of dry preparation. Throughout this specification, many papers and patent documents are referenced and their citations are indicated. The disclosures of cited papers and patent documents are incorporated herein by reference in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained. [Content of invention]
【기술적 과제】 [Technical problem]
본 a명자들은 광ᅳ열 안정성이 낮은 주름 개선 및 미백 원료의 변성을 차단하여 기능성 원료의 특성을 오래 유지시켜 주고， 광-열 안정성을 강화시키고자 예의 노력하였다. 그 결과, 친수계 스멕타이트 점토광물 층간에 주름 개선 또는 미백 원료가 치환된 기능성 복합체를 제조하고， 이를 포함하여 기능성 화장품을 제조함으로써 광 -열에 의한 주름 개선 또는 미백 원료의 변성을 차단하여 기능성 성분의 특성을 오래 유지시켜 주며， 제형의 안정성을 강화시킬 수 있다는 것을 발견하여 본 발명을 완성하였다. This will give a designee by blocking the metabolism of the low anti-wrinkle and whitening ingredients light eu thermal stability to achieve the best properties of the functional material, the light-tried thermal stability and enhance the character cases. As a result, the functional composite of the hydrophilic smectite clay mineral layer is prepared by improving the wrinkles or replacing the whitening raw material, and manufacturing functional cosmetics including the same. The present invention has been completed by discovering that it can keep a long time and enhance the stability of the formulation.
이에 본 발명은 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체， 그 제조방법 및 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체를 포함하는 기능성 화장품을 제공하는데 그 목적이 있다. Accordingly, an object of the present invention is to provide a functional cosmetic comprising a wrinkle improving or whitening raw material compound-hydrophilic smectite clay mineral composite, a method for manufacturing the same and a wrinkle improving or whitening raw material compound-hydrophilic smectite clay mineral composite.
【기술적 해결방안】 Technical solution
본 발명은 주름 개선 또는 미백을 위한 원료 화합물-친수계 스멕타이트 점토광물 복합체를 포함하고， 300— 800nm 파장대의 765W/[n2의 광원에 노출 시 48 시간 경과 후의 색차값 (ΔΕ).이 1.0 이하를 만족하는 광-열 안정성이 우수한 주름 개선 또는 미백 기능성 화장품을 제공한다. The present invention includes a raw material compound-hydrophilic smectite clay mineral composite for wrinkle improvement or whitening, and has a color difference value (ΔΕ) after 48 hours when exposed to a light source of 765W / [n 2 in the 300-800 nm wavelength range. Provides excellent wrinkle improvement or whitening functional cosmetics that satisfy the light-thermal stability.
상기 주름 개선을 위한 원료 화합물은 레티놀， 레티닐팔미테이트.. 아데노신 및 폴리에록실레이티드레틴아마이드로 이루어진 군에서 선택된 1 종 이상을 포함하는 것일 수 있다. The raw material compound for improving wrinkles may include one or more selected from the group consisting of retinol, retinyl palmitate .. adenosine and polyethoxylatedretinamide.
상기 미백을 위한 원료 화합물은 닥나무 추출물, 알부틴, 에칠아스코빌에텔， 유용성 감초추출물, 아스코빌글루코사이드, 마그네슘아스코빌포스페이트， 나이아신아마이드, 알파-비사보롤 및 아스코빌테트라이소팔미테이트로 이루어진 군에서 선택된 1종 이상을 포함하는 것일 수 있다. The raw material for the whitening is the extract of the mulberry, arbutin, ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, It may be one or more selected from the group consisting of niacinamide , alpha-bisabolol and ascorbyl tetraisopalmitate.
상기 친수계 스멕타이트 점토광물이 몬트모릴로나이트, 벤토나이트 및 헥토라이트로 이루어진 군에서 선택된 1종 이상을 포함하는 것일 수 있다. The hydrophilic smectite clay mineral may be one or more selected from the group consisting of montmorillonite, bentonite and hectorite.
상기 주름 개선 또는 미백을 위한 원료 화합물-친수계 스멕타이트 점토광물 복합체는 주름 개선 또는 미백을 위한 원료를 0.1~20 중량? ¾로 포함하는 것일 수 있다. The raw material compound-hydrophilic smectite clay mineral composite for wrinkle improvement or whitening is 0.1-20% by weight of the raw material for wrinkle improvement or whitening? It may be included as ¾.
또한, 본 발명은 친수계 스멕타이트 점토광물에 주름 개선 또는 미백을 위한 원료 원료 화합물은 인터칼레이션된 기능성 복합체 및 상기 기능성 복합체의 주름개선 또는 피부 미백용 기능성 화장품 제조를 위한 용도를 제공한다. In addition, the present invention provides a raw material compound for improving or whitening wrinkles in hydrophilic smectite clay minerals, and the use of intercalated functional complexes and functional cosmetics for wrinkle improvement or skin whitening of the functional complexes.
상기 주름 개선을 위한 원료 화합물은 레티놀, 레티닐팔미테이트， 아데노신 및 폴리에특실레이티드레틴아마이드로 이루어진 군에서 선택된 1 종 이상을 포함할 수 있다. The raw material compound for improving wrinkles may include at least one selected from the group consisting of retinol, retinyl palmitate, adenosine, and polyeisiletidretinamide.
상기 미백을 위한 원료 화합물은 닥나무 추출물 알부틴. 에칠아스코빌에텔， 유용성 감초추출물, 아스코빌글루코사이드， 마그네슘아스코빌포스페이트, 나이아신아마이드, 알파-비사보를 및 아스코빌테트라이소팔미테이트로 이루어진 군에서 선택된 1종 이상을 포함할 수 있다. The raw material for the whitening is the extract of arborine arborin. It may include one or more selected from the group consisting of ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, niacinamide, alpha-bisabolic and ascorbyl triisopalmitate.
상기 친수계 스멕타이트 점토광물이 몬트모릴로나이트, 벤토나이트 및 핵토라이트로 이루어진 군에서 선택된 1종 이상을 포함할 수 있다. The hydrophilic smectite clay mineral may include one or more selected from the group consisting of montmorillonite, bentonite, and nuclear thorite.
상기 기능성 복합체가 주름 개선 또는 미백을 위한 원료 화합물을 0.1~20 중량 %로 포함할 수 있다. The functional composite may include 0.1 to 20% by weight of the raw material compound for wrinkle improvement or whitening.
상기 기능성 복합체는 주름 개선 또는 미백을 위한 원료 화합물을 포함하고， 300- 800nm 파장대의 765W/m2 의 광원에 48 시간 노출 후 색차값 (ΔΕ)이 1.0 이하를 나타내어 광-열 안정성이 우수하기 때문에 주름 개선 또는 미백효과가 있는 화장품을 제조하는 용도로 사용할 수 있다. The functional composite includes a raw material for wrinkle improvement or whitening, and has a color difference value (ΔΕ) of 1.0 or less after 48 hours exposure to a 765W / m 2 light source in the 300-800 nm wavelength range, so that the light-thermal stability is excellent. It can be used to manufacture cosmetics with wrinkle improvement or whitening effect.
또한, 본. 발명은 (1) 친수계 스멕타이트 점토광물 0.1-1.0 중량부를 증류수 50.0-70.0 중량부에 첨가하여 호모믹서로 1,000~5，000 rpra 에서 분산한 후, 20~30°C에서 24~30 시간 교반하여 친수계 스멕타이트 점토광물의 수분산액을 수득하는 단계; (2) 주름 개선 또는 미백을 위한 원료 화합물 0.05-0.5 중량부를 증류수 5.0-10.0 중량부 및 알코올 용매 20.0~30·0 중량부에 용해시키는 단계: (3) 상기 (2) 단계에서 얻어진 용액을 (1) 단계에서 수득한 수분산액에 투.입하여 20-30 시간 교반하여 혼합하는 단계; (4) 상기 (3) 단계에서 얻어진 혼합물을 12,000~16,000rpm 으로 원심분리한 다음, 3~6 회 수세한 후. -5으 40°C에서 65~80 시간 동결건조하는 단계를 포함하는 주름 개선 및 미백 원료-친수계 스멕타이트 층간물질 복합체의 제조방법을 제공한다. Also seen . (1) 0.1-1.0 parts by weight of hydrophilic smectite clay mineral was added to 50.0-70.0 parts by weight of distilled water and dispersed at 1,000-5,000 rpra with a homomixer, followed by stirring at 20-30 ° C. for 24-30 hours. Aqueous dispersion of hydrophilic smectite clay mineral Obtaining; (2) dissolving 0.05-0.5 parts by weight of the raw material compound for wrinkle improvement or whitening in 5.0-10.0 parts by weight of distilled water and 20.0-30.0 parts by weight of alcohol solvent: (3) the solution obtained in step (2) above ( Adding to the aqueous dispersion obtained in step 1) and mixing by stirring for 20-30 hours; (4) After centrifuging the mixture obtained in the step (3) at 12,000 ~ 16,000rpm, and then washed 3 to 6 times. It provides a method for producing a wrinkle-improving and whitening raw material-hydrophilic smectite interlayer composite comprising the step of -5 lyophilization at 40 ° C 65-80 hours.
【유리한 효과] Advantageous Effects
본 발명의 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체는 주름 개선 또는 미백 기능성 화장품에 포함되어 광 -열에 의한 주름 개선 또는 미백 원료의 변성을 차단하여 기능성 원료의 특성을 오래 유지시켜 주고, 제형의 안정성을 강화시킬 수 있으며, 궁극적으로 광-열 안정성이 우수한 주름 개선 또는 미백 원료를 제공할 수 있다. Wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral complex of the present invention is included in the wrinkle improvement or whitening functional cosmetics to maintain the properties of the functional raw material by preventing the wrinkle improvement by light-heat or the modification of the whitening raw material, It is possible to enhance the stability of the formulation, and ultimately to provide wrinkle improvement or whitening raw materials with excellent light-thermal stability.
【도면의 간단한 설명】 [Brief Description of Drawings]
도 1 은 인터칼레이션 반응에 의해 층상형 점토광물 층간에 기능성 물질을 치환하여 기능성 복합체를 제조하는 공정을 나타낸 그림이다. 1 is a diagram illustrating a process of preparing a functional complex by replacing a functional material between layers of layered clay minerals by an intercalation reaction.
도 2 는 X-선 회절 패턴 분석을 통해 미백 원료인 알부틴의 함량에 따른 층간 간격올 나타낸 그래프이다. Figure 2 is a graph showing the interlayer spacing depending on the content of the arbutin raw material whitening through X-ray diffraction pattern analysis.
도 3 은 실시예 7 및 비교예 7 을 선크림 제형에 적용 후， 광 -열에 따른 색상 변화를 나타낸 그림이다. 3 is a view showing the color change according to light-heat after applying Example 7 and Comparative Example 7 to the sunscreen formulation.
【발명의 실시를 위한 형태】 [Form for implementation of invention]
본 발명에서 주름 개선 또는 미백을 위한 원료 화합물—친수계 스멕타이트 점토광물 복합체' 라 함은 인터칼레이션 반응을 이용하여 친수계 스멕타이트 점토광물 층간에 주름 개선 또는 미백을 위한 원료 화합물을 치환하여 생성된 기능성 복합체를 의미한다 . In the present invention, the raw material compound for improving or whitening wrinkles—hydrophilic smectite clay mineral complex 'is a functional product produced by substituting a raw material for wrinkle improvement or whitening between hydrophilic smectite clay mineral layers using an intercalation reaction. Means complex.
본 발명에서 '스멕타이트' 라 함은 점토광물의 하나로서 염기가 높은 반려암의 풍화에 의해서 생성되는 것을 의미한다. 본 발명에서 '점토광물' 이라 함은 점토가 가진 특성을 나타내는 것으로 이루어진 광물로서， 산출상태가 주로 점토인 규산염광물로 극히 미세한 광물 입자로 된 토상 광물의 총칭을 의미한다. In the present invention, the term "smectite" is one of clay minerals, which means that it is produced by weathering a high-base companion rock. In the present invention, the term "clay mineral" refers to a mineral composed of clay, which is a silicate mineral whose output state is mainly clay, and refers to a general term of earth minerals composed of extremely fine mineral particles.
본 발명에서 '인터칼레이션' 이라 함은 층상구조가 있는 물질의 층간에 분자， 원자와 이온이 삽입되는 현상을 의미하며, 인터칼레이션의 생성물을 층간 화합물이라 한다. In the present invention, the term "intercalation" refers to a phenomenon in which molecules, atoms, and ions are inserted between layers of a layered material, and the product of intercalation is called an interlayer compound.
본 발명은 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체를 포함하고, 300-800議 파장대의 765W/I112의 광원을 조사 후 48 시간 경과 후의 색차값 (ΔΕ)이 1.0 이하를 만족하는 광-열 안정성이 우수한 기능성 화장품을 제공한다. The present invention includes an anti-wrinkle or whitening raw material compound-hydrophilic smectite clay mineral complex, and the color difference value (ΔΕ) after 48 hours after irradiation with a light source of 765W / I11 2 in the 300-800 議 wavelength band satisfies 1.0 or less. It provides a functional cosmetic having excellent light-heat stability.
상기 주름 개선을 위한 원료 화합물은 레티놀， 레티닐팔미테이트， 아데노신 및 폴리에톡실레이티드레틴아마이드로 이루어진 군에서 선택된 1 종 이상을 포함할 수 있다. The raw material compound for improving wrinkles may include at least one selected from the group consisting of retinol, retinyl palmitate, adenosine, and polyethoxylatediretinamide.
상기 미백을 위한 원료.화합물은 닥나무 추출물. 알부틴， 에칠아스코빌에텔, 유용성 감초추출물， 아스코빌글루코사이드， 마그네슘아스코빌포스페이트， 나이아신아마이드， 알파-비사보를 및 아스코빌테트라아소팔미테이트로 이루어진 군에서 선택된 .1종 이상을 포함할 수 있다. Raw material for whitening. Arbutin, ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, niacinamide, alpha-bisabo and ascorbyl tetraaspalmitate.
상기 주름 개선 또는 미백을 위한 원료 화합물은 식품 의약품 안전청에서 고시한 성분이며， 유기 물질이기 때문에 광 또는 열에 의해 쉽게 변성되어 안정성이 저하되고 고유의 기능을 쉽게 잃어버리는 특성을 갖는 원료를 의미할 수 있다. 또한， 상기 주름 개선 원료 또는 미백 원료는 단독으로 사용할 수 있고， 상기 원료를 혼합하여 사용할 수 있다. The raw material compound for improving wrinkles or whitening is a component notified by the Food and Drug Administration, and because it is an organic material, it may mean a raw material that has a property of being easily denatured by light or heat to degrade stability and easily lose its own function. . In addition, the wrinkle improving raw material or whitening raw material may be used alone, the raw material may be mixed.
본 발명의 바람직한 양태에 따르면, 상기 주름 개선 또는 미백을 위한 원료 화합물-친수계 스멕타이트 점토광물 복합체에서 친수계 스멕타이트 점토광물을 사용할 수 있는데， 구체적인 예로는 몬트모릴로나이트 벤토나이트 및 핵토라이트로 이루어진 군에서 선택된 1 종 이상을 사용하는 것이 물과 함께 이용함으로써 수 A〜수십 A까지 층간 벌어짐이 쉽게 일어나기 때문에 활성 물질의 층간 삽입이 유용하다. 본 발명의 바람직한 양태에 따르면, 주름 개선 또는 미백을 위한 원료 화합물- 친수계 스멕타이트 점토광물 복합체가 주름 개선 또는 미백을 위한 원료 화합물을 0.1-20 중량 %로 포함할 수 있다. 기능성 복합체 중 주름 개선 및 미백 원료의 함량이 0.1% 미만일 경우에는 화장품 응용에 있어서 적합하지 않고 , 20 중량 %를 초과하여 응용하기에는 어려움이 있다 . According to a preferred embodiment of the present invention, a hydrophilic smectite clay mineral may be used in the raw material compound-hydrophilic smectite clay mineral complex for improving wrinkles or whitening, and specific examples thereof include montmorillonite bentonite and hackiteite. Intercalation of the active material is useful because the use of one or more selected species with water leads to easy intercalation between several A and several tens A. According to a preferred embodiment of the present invention, the raw material compound for improving wrinkles or whitening-hydrophilic smectite clay mineral complex may include 0.1-20% by weight of the raw material compound for improving wrinkles or whitening. When the content of wrinkle improvement and whitening raw materials in the functional composite is less than 0.1%, it is not suitable for cosmetic applications, and it is difficult to apply more than 20% by weight.
본 발명의 바람직한 양태에 따르면, 상기 주름 개선 또는 미백올 위한 원료 화합물-친수계 스멕타이트 점토광물 복합체는 화장품 중 주름 개선 또는 미백 원료 화합물은 식품 의약품 안정청의 고시된 함량에 따라 적용될 수 있다. According to a preferred embodiment of the present invention, the raw material compound-hydrophilic smectite clay mineral complex for wrinkle improvement or whitening may be applied according to the published content of the Food and Drug Administration for wrinkle improvement or whitening source compound in cosmetics.
본 발명의 바람직한 양태에 따르면， 상기 광-열 안정성이 우수한 기능성 화장품은 광원에 조사 후 48 시간 경과 후의 색차값 (ΔΕ)이 1.0 이하를 만족할 수 있다ᅳ 색차값 (ΔΕ)이 1.0 이상일 경우에는 외관색상의 차이가 크게 일어났음을 뜻하게 되고 첨가된 주름 개선 혹은 미백 원료 화합물이 변형되었음을 알 수 있다. According to a preferred embodiment of the present invention, the functional cosmetics having excellent light-thermal stability may satisfy a color difference value ΔΕ of 1.0 or less after 48 hours after irradiation with a light source. It means that the color difference has occurred greatly, and it can be seen that the wrinkle improvement or whitening raw material compound added is modified.
본 발명은 친수계 스멕타이트 점토광물에 주름 개선 및 미백 원료가 인터칼레이션된 기능성 복합체를 제공한다. The present invention provides a functional complex in which the wrinkle-improving and whitening raw material is intercalated in a hydrophilic smectite clay mineral.
상기 주름 개선 원료， 미백 원료 및 친수계 스멕타이트 점토광물에 대한 구체적인 내용 및 혼합비는 상술한 것과 같다. . Specific contents and mixing ratios of the wrinkle improving raw material, the whitening raw material and the hydrophilic smectite clay mineral are as described above. .
본 발명의 일 실시예에 따른 주름 개선 및 미백 원료-친수계 스멕타이트 층간물질 복합체의 제조방법은 (1) 친수계 스멕타이트 점토광물 0.1-1.0 중량부를 증류수 50.0-70.0 중량부에 첨가하여 호모믹서로 1,000 5,000 rpm 에서 분산한 후， 20~30°C에서 24~30 시간 교반하여 친수계 스멕타이트 점토광물의 수분산액을 수득하는 단계; (2) 주름 개선 또는 미백올 위한 원료 화합물 0.05~0.5 중량부를 증류수 5.0~10.0 중량부 및 알코올 용매 20.0 30.0 중량부에 용해시키는 단계; (3) 상기 (2) 단계에서 얻어진 용액을 상기 (1) 단계에서 수득된 수분산액에 투입하여 2(K30 시간 교반하여 혼합하는 단계; (4) 상기 (3) 단계에서 얻어진 흔합물을 12,000~16,000rpm 으로 원심 분리한 다음， 3~6 회 수세한 후， -5으 40°C에서 65~80시간 동결 건조하는 단계를 포함하는 것이다. Wrinkle improvement and whitening raw material-hydrophilic smectite interlayer composite production method according to an embodiment of the present invention (1) 0.1-1.0 parts by weight of hydrophilic smectite clay mineral is added to 50.0-70.0 parts by weight of distilled water 1,000 in a homomixer After dispersing at 5,000 rpm, stirring at 20-30 ° C. for 24-30 hours to obtain an aqueous dispersion of hydrophilic smectite clay mineral; (2) dissolving 0.05 to 0.5 parts by weight of the raw material compound for wrinkle improvement or whitening, 5.0-10.0 parts by weight of distilled water and 20.0 30.0 parts by weight of alcohol solvent; (3) adding the solution obtained in step (2) to the aqueous dispersion obtained in step (1) and mixing the mixture by stirring for 2 hours (K30 hours; (4) mixing the mixture obtained in step (3) in the range of 12,000 to After centrifugation at 16,000rpm, washed 3 to 6 times, freeze-dried at -5 to 40 ° C for 65 to 80 hours.
본 발명의 바람직한 양태에 따르면, 상기 (1) 단계에서 호모믹서로 1,000~5，000 rpm 에서 분산한 후, 20-30 °C에서 24~30 시간 교반하는 것이 친수계 스멕타이트 점토광물의 1 차 팽윤을 효과적으로 진행시키기 때문에 바람직하다. 친수계 스멕타이트 점토광물은 물에 의해서 1 차 팽윤이 발생하게 되는데 별도의 화학반응이 아니라 점토광물의 특성에 기인한 현상이다. 호모 믹서의 단계가 lOOOrpm 미만일 경우에는 친수계 스멕타이트 점토광물의 분산성이 떨어지고, SOOOrpm 을 초과할 경우에는 층간 팽윤에 따른 층간 배열이 무너지게 된다. 또한 20~30°C의 범위를 벗어난 경우의 은도에서는 친수계 스멕타이트 팽윤력이 저하되고, 24시간 이상 교반을 해야만 1차 팽윤이 완벽하게 이루어진다. According to a preferred embodiment of the present invention, after dispersing at 1000 ~ 5,000 rpm with a homomixer in the step (1), it is a hydrophilic smectite to stir at 20-30 ° C for 24 to 30 hours It is preferable because it effectively advances primary swelling of the clay mineral. In hydrophilic smectite clay minerals, the primary swelling is caused by water, which is due to the characteristics of the clay minerals, not a separate chemical reaction. If the stage of the homo mixer is less than 100 rpm, the dispersibility of the hydrophilic smectite clay mineral is inferior, and if it exceeds SOOO rpm, the interlayer swelling due to the interlayer swelling is collapsed. In addition, in the case of the silver outside the range of 20 ~ 30 ° C hydrophilic smectite swelling power is lowered, the primary swelling is completed only when stirring for 24 hours or more.
본 발명의 바람직한 양태에 따르면, 상기 (3) 단계에서 수분산액에 투입하여 20-30 시간 교반하는 것이 주름 개선 또는 미백을 위한 원료 화합물이 효과적으로 치환이 된다. 화장품 원료에 적용되기 위해서는 화학적 반응을 적용시기는 것보다는 이온 교환을 통한 방법이 가장 효율적이다. 이를 위해서는 20 시간 이상 교반을 시켜야만 주름개선 또는 미백 원료가 효과적으로 치환이 이루어진다. According to a preferred embodiment of the present invention, in the step (3) is added to the aqueous dispersion and stirred for 20-30 hours, the raw material compound for wrinkle improvement or whitening is effectively substituted. In order to be applied to cosmetic raw materials, ion exchange is more efficient than chemical reaction. To this end, agitation should be performed for 20 hours or more to effectively replace wrinkles or whitening raw materials.
본 발명의 바람직한 양태에 따르면 상기 (4) 단계에서 12， 000-16 ,000rpm 으로 원심분리한 다음, 3~6 회 수세한 후， -5으 40°C에서 65~80 시간 동결 건조하는 것이 친수계 스멕타이트 점토광물의 층간 구조를 무너뜨리지 않고 주름 개선 또는 미백 원료가 효과적으로 층간 구조 내에 고정화된다. 일반적인 열에 의한 건조공정에 따르면 친수계 스멕타이트의 층간 구조가 무너지고 주름개선 또는 미백원료가 층간 구조 밖으로 빠져나오게 된다. 이하， 실시예를 통하여 본 발명을 더욱 상세히 설명 하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로서， 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 본 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에게 있어서 자명할 것이다. 실시예 1. 수화—팽윤 공정에 의한 주름 개선 또는 미백을 위한 원료 화합물- 친수계 스멕타이트 점토광물 복합체 제조 According to a preferred embodiment of the present invention, after centrifugation at 12, 000-16,000rpm in the step (4), washed with 3-6 times, freeze-dried at -5 to 40 ° C 65-80 hours Wrinkle improvement or whitening raw materials are effectively immobilized in the interlaminar structure without destroying the interlaminar structure of the aqueous smectite clay mineral. According to a general heat drying process, the interlayer structure of hydrophilic smectite is broken and wrinkle improvement or whitening material is taken out of the interlayer structure. Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident. Example 1 Preparation of Hydration—Raw Compound for Wrinkle Improvement or Whitening by Swelling Process—Hydrophilic Smectite Clay Mineral Complex
본 발명의 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체를 제조함에 있어서， 본 실시예에서는 친수계 스멕타이트 점토광물로서 핵토라이트 (제품명: BENT0NE EW, 구입처: Elementis special ties (USA)) 를 사용하였다. 핵토라이트는 층간 구조를 갖는 물질로써 각각의 금속 산화물을 포함하는 샌드위치 구조의 독립된 판상 구조를 이루고 있고， 그 화학명은 Na0.33[Mg2.67Li0.33]Si4010[OH]2 이며， 가늘고 긴 구조로 이루고 있으며 Trioctahederal 결정 구조를 이루고 있으며， 35 배의 물을 포집할 수 있다. 핵토라이트 점토광물 (BENTONE EW)의 양이은 교환 능력은 50meq/100g 이상을 가지는 점토 광물 이며, 표면 개질이 이루어지지 않은 친수성 특성을 가진다. 소수성 특징을 가질 경우, 염기성 물질을 이용하여 표면 전하 개질이 이루어져야 하므로 산업적으로 이용하기에는 적절하지 않으므로 친수성 특성을 가진 BENTONE EW 를 직접 사용하였다. 또한， 본 실시예에서는 주름 개선 또는 미백 원료 화합물로서 미백 원료인 알부틴을 이용하였으며， 알부틴은 화장품 식약청 미백 기능성 고시원료로써， 화학명은 (2R,3S,4S,5R,6S)-2-Hydroxymethy 6-(4- hydroxyphenoxy)oxane-3 , 4 , 5-tr iol이며. SHUIZHOUARTEC 제품을 이용하였다. In preparing the wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite of the present invention, in the present embodiment, as a hydrophilic smectite clay mineral, Hectorite (product name: BENT0NE EW, purchased from Elementis special ties (USA)) was used. Hectorite is a material having an interlaminar structure, which forms an independent plate-like structure of a sandwich structure including each metal oxide, and its chemical name is Na 0 . 33 [Mg 2.67 Li 0 . 33 ] Si 4 0 10 [OH] 2 , thin and long, with trioctahederal crystals, capable of capturing up to 35 times water. The heterogeneous exchange capacity of the Hectorite clay mineral (BENTONE EW) is a clay mineral with 50 meq / 100g or more, and has hydrophilic properties without surface modification. In case of having hydrophobic characteristics, BENTONE EW having hydrophilic characteristics was directly used because it is not suitable for industrial use because surface charge modification should be performed using basic materials. In addition, in the present embodiment, a whitening raw material arbutin was used as an anti-wrinkle or whitening raw material compound, and the arbutin was a whitening functional raw material of the KFDA. The chemical name was (2R, 3S, 4S, 5R, 6S) -2-Hydroxymethy 6-. (4-hydroxyphenoxy) oxane-3, 4, 5-tr iol. SHUIZHOUARTEC products were used.
본 발명의 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체는 하기 표 1의 배합량을 토대로 하기와 같이 제조하였다. The wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite of the present invention was prepared as follows based on the blending amount of Table 1 below.
1) 핵토라이트 점토광물을 증류수에 첨가하여 호모믹서로 .2.,000rpm 에서 분산한 후， 25°C에서 24시간 교반하여 핵토라이트 점토광물의 수분산 액을 얻었다. 1) Haktorite clay mineral was added to distilled water and dispersed at .2., 000rpm with a homomixer, followed by stirring at 25 ° C. for 24 hours to obtain an aqueous dispersion of nucleite clay mineral.
2) 미백 원료인 알부틴을 증류수 및 에탄올에 용해시켰다 .  2) Arbutin, a whitening raw material, was dissolved in distilled water and ethanol.
3) 상기 2) 단계의 용액을 1) 단계의 수분산액에 투입하여, 24 시간 교반하여 흔합시켰다.  3) The solution of step 2) was added to the aqueous dispersion of step 1), followed by stirring for 24 hours to mix.
4) 상기 3) 단계의 흔합물을 M.OOOrpm 으로 원심분리 한 다음， 3 회 수세한 후， 5iii torr 조건으로 -45°C에서 72시간 동결건조하였다. 4) The mixture of step 3) was centrifuged with M.OOrpm, washed three times, and lyophilized at -45 ° C for 72 hours under 5iii torr conditions.
주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체의 원료 조성은 하기 표 1과 같다. The raw material composition of the wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite is shown in Table 1 below.
얻어진 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체 중의 알부틴의 함량은 고성능 액체크로마토그래프 (HPLC, 일본국, 시마즈 (Shimadzu), LC-10VP)로 측정하였다. 【표 1】 The content of arbutin in the obtained wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite was measured by high performance liquid chromatography (HPLC, Japan, Shimadzu, LC-10VP). Table 1
Figure imgf000013_0001
비교예 1. 건식 공정에 의한 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체 제조 (특허출원 KR 10-2007-0105488 기재된 방법 참조)
Figure imgf000013_0001
Comparative Example 1. Wrinkle improvement or whitening raw material compound-drying hydrophilic smectite clay mineral composite by dry process (see patent application KR 10-2007-0105488 described method)
핵토라이트 점토광물에 알부틴， 증류수 및 에 탄올을 하기 조성과 같이 첨 가하여 혼합한 다음 아게이트 모르타르 (막자 사발)에 투입하여 상온에서 60 분동안 혼합한 후， 60 °C에서 2 시간동안 열처 리하여 캡슬화하였다. Arbutin, distilled water and ethanol were added to Hectorite clay minerals as shown in the following composition, mixed, and then mixed in an agate mortar (mold bowl) for 60 minutes at room temperature, followed by heat treatment at 60 ° C. for 2 hours to encapsulate. It was.
【표 2】 Table 2
Figure imgf000014_0001
Figure imgf000015_0001
실험예 1. X-선 회절 패턴 분석
Figure imgf000014_0001
Figure imgf000015_0001
Experimental Example 1. X-ray diffraction pattern analysis
상기 실시예 1~6 및 비교예 1~6 로부터 제조된 주름 개선 또는 미백 원료 화합물- 친수계 스멕타이트 점토광물 복합체의 층상 구조 분석은 X-선 분석기를 이용하였으며, X-분말 회절 패턴은 Cu-Ka ^^10^파장:0.1540¾111)을 광원으로 이용하는 Rigaku diffractometer(D/M -2200 ultima)를 이용하였다.  The layered structure analysis of the wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral composite prepared from Examples 1 to 6 and Comparative Examples 1 to 6 was performed using an X-ray analyzer, and the X-powder diffraction pattern was Cu-Ka. Rigaku diffractometer (D / M-2200 ultima) using ^^ 10 ^ wavelength: 0.1540¾111) as a light source was used.
하기 표 3 및 표 4 는 X-선 회절 패턴 분석을 통한 알부틴의 함량에 따른 기능성 복합체의 층간 간격을 나타낸 것이다. 대조구는 알부틴을 처리하지 않은 스멕타이트 점토광물 복합체의 층간 간격을 나타낸 것이다.  Table 3 and Table 4 show the interlayer spacing of the functional complex according to the content of arbutin through the X-ray diffraction pattern analysis. The control shows the interlayer spacing of smectite clay mineral complexes not treated with arbutin.
【표 3] [Table 3]
Figure imgf000015_0002
그 결과 핵토라이트 100 중량부 대비 알부틴 첨가량이 20 중량부 이상인 실시예 3-6 의 층간거리는 14.9 A로 핵토라이트 점토광물의 초기 격자두께가 10.7 A임을 고려하면 알부틴의 층간 삽입에 따라 약 4.2 A정도 층간 거리가 확장되어 미백 원료인 알부틴이 효과적으로 층간 삽입됨을 알 수 있었다. 또한， 알부틴의 투입량이 증가할수톡 층간 거리가 커지는 것으로 나타났는데, 이는 알부틴의 투입량이 증가할수록 점토광물 층간에 삽입된 알부틴의 양도 증가하는 것을 말해주는 결과이다.
Figure imgf000015_0002
As a result, the interlayer distance of Example 3-6 having an arbutine added amount of 20 parts by weight or more relative to 100 parts by weight of hacklite was 14.9 A, considering that the initial lattice thickness of the hackite clay mineral was 10.7 A. As the interlayer distance was extended, arbutin, a whitening material, was effectively inserted into the interlayer. In addition, the distance between the layers of the arbutin was increased to increase the amount of arbutin. As the dosage increases, the amount of arbutin intercalated into the clay mineral layer increases.
하지만, 비교예의 경우 핵토라이트 100 중량부 대비 알부틴 첨가량이 10 중량부 이상인 비교예 2~6 은 층간거리가 12.9 A로 실시예와 비교하였을 경우, 알부틴의 층간 삽입이 어려움을 알 수 있다. 이는 실시예와 같은 경우에는 미백 원료를 삽입하기 전 핵토라이트 점토광물의 수화-팽윤에 따른 층분한 층간 벌어짐이 발생하여 미백 원료의 삽입이 용이하지만， 비교예와 같은 경우에는 팽윤보다는 물리적인 압력에 의해 삽입하였기 때문에 알부틴의 담지량에 있어서 한계가 ᄆ 一「 . However, Comparative Examples 2 to 6 in which the arbutin added amount is 10 parts by weight or more with respect to 100 parts by weight of hackiteite, when the interlayer distance is 12.9 A, it can be seen that the interlayer insertion of arbutin is difficult. In the case of the embodiment, before the insertion of the whitening raw material, the interlayer lamellae occurs due to hydration and swelling of the clayite mineral, so that the insertion of the whitening raw material is easy. The limit on the amount of arbutin supported by the
도 2 는 X-선 회절 패턴 분석을 통한 알부틴의 함량에 따른 층간 간격 '을 나타낸 그래프이다. 도 2 의 그래프에서 나타난 바와 같이 핵토라이트의 점토광물의 수화-팽윤을 이용한 방법은 실시예 3 의 핵토라이트 100 중량부 대비 알부틴 첨가량이 20중량부까지 효과적으로 층간 삽입이 가능함을 보여준다. 실험예 2. 광-열 조사에 따른 변성 테스트 2 is a graph showing the interlayer spacing 'according to the content of arbutin through the X-ray diffraction pattern analysis. As shown in the graph of FIG. 2, the method using the hydration-swelling of the clay mineral of nuclear lightite shows that the amount of arbutin added to 20 parts by weight based on 100 parts by weight of the nuclear light of Example 3 can be effectively intercalated. Experimental Example 2. Denaturation test by light-heat irradiation
본 발명의 열 -광에 따른 변성테스트는 주름 개선 또는 미백 원료 화합물-친수계 스멕타이트 점토광물 복합체를 선크림 제형 적용 후. 선테스트기를 이용하여 측정하였다. 복합체 첨가량은 알부틴 함량이 선크림 제형 중 2.0 중량 %되는 양만큼 사용하였다. 선테스트기는 ATLAS 사의 suntest CPS+ 를 이용하였으며， 내부 온도는 40°C, Xenon lamp를 이용하여 300-800ηηι 파장대의 765W/m2의'광원을 48 시간동안 조사하여 비교 분석하였다. 이는 일광에서 12 일 노출시킨 것과 동일한 효과를 부여하는 것과 같다. 48 시간 조사한 다음 48 시간 경과 후의 색차값 (ΔΕ)을 비교 분석하였다. 색상차의 정도는 0 0.5 는 색차를 거의 느끼지 못하고， 0.6-1.0 은 극히 적은 색차를 느끼고, 1.1 1.5 는-색차는 느껴지나 일반적으로 통용되고, 1.6 2.0는 색차가 크다. The denaturation test according to the heat-light of the present invention after applying the sunscreen formulation to wrinkle improvement or whitening raw material compound-hydrophilic smectite clay mineral complex. It measured using the pretest machine. The amount of the complex added was used in an amount such that the arbutin content was 2.0% by weight in the sunscreen formulation. Suntest CPS + of ATLAS Co., Ltd. was used. The internal temperature of 40 ° C. and Xenon lamp were used to compare the light source of 765W / m 2 in the wavelength range of 300-800ηηι for 48 hours. This is equivalent to giving the same effect as 12 days of exposure in daylight. After 48 hours of irradiation, color difference (ΔΕ) after 48 hours was analyzed. The degree of color difference is 0 0.5 almost no color difference, 0.6-1.0 feels very little color difference, 1.1 1.5-color difference is common but commonly used, 1.6 2.0 is large color difference.
선크림 제형의 조성은 표 5(단위:중량 ¾)과 같다. The composition of the sunscreen formulation is shown in Table 5 (unit: weight ¾).
【표 5】
Figure imgf000017_0001
Table 5
Figure imgf000017_0001
【표 6]
Figure imgf000017_0002
그 결과， 실시예 7 은 색차값 (ΔΕ)이 0.15 로 48 시간 이후에도 큰 변화가 없다는 것을 알 수 있었으나, 비교예 7은 색차값 (ΔΕ)이 1.85로 색상 변형이 일어났음을 확인 할 수 있었다 (도 3 참조). 이는 미백 원료인 알부틴이 열 또는 광에 의해 변형이 일어나 제형 안정성에 영향을 끼침을 예측할 수 있었다. · [Table 6]
Figure imgf000017_0002
As a result, it was found that in Example 7, the color difference value ΔΕ was 0.15 and there was no significant change even after 48 hours, but in Comparative Example 7, the color difference value ΔΕ was 1.85 and color deformation occurred. Could be confirmed (see Figure 3). This could predict that arbutin, a whitening raw material, was modified by heat or light, affecting formulation stability. ·
결과적으로 본 발명의 기능성 화장품은 광-열 안정성이 우수함을 확인할 수 있다. As a result, the functional cosmetics of the present invention can be confirmed that the excellent light-thermal stability.
【산업상 이용가능성】 Industrial Applicability
본 발명의 주름 개선 또는 미백 원료 화합물과 친수계 스멕타이트 점토 광물이 결합한 복합체는 광 -열에 의한 주림 개선 또는 미백 원료의 변성을 차단하기 때문에 기능성 원료의 특성을 오래 유지시켜주고, 제형의 안정성을 강화시킬 수 있어， 주름 개선 또는 미백 효과를 갖는 화장품올 제조하는데 사용할 수 있어 , 산업상 이용가능성이 높다. The composite of the wrinkle improvement or whitening raw material compound of the present invention and the hydrophilic smectite clay mineral combine to improve the properties of the functional raw material and enhance the stability of the formulation since it prevents light-heating and improves the whitening raw material. It can be used to produce cosmetics having wrinkle improvement or whitening effect, and thus has high industrial applicability.

Claims

【청구의 범위】 [Range of request]
【청구항 1]  [Claim 1]
주름 개선 또는 미백을 위한 원료 화합물ᅳ친수계 스멕타이트 점토광물 복합체를 포함하고， 300-800nm 파장대의 765W/m2 의 광원에 48 시간 노출된 후의 색차값 (ΔΕ)이 1.0 이하를 만족하는 광-열 안정성이 우수한 기능성 화장품. Raw material compound for improving wrinkles or whitening 광 Light-heat including a hydrophilic smectite clay mineral complex and a color difference value (ΔΕ) satisfying 1.0 or less after 48 hours exposure to a 765W / m 2 light source in the 300-800 nm wavelength range. Functional cosmetics with excellent stability.
【청구항 2】 [Claim 2]
제 1 항에 있어서, The method of claim 1,
상기 주름 개선을 위한 원료 화합물이 레티놀， 레티닐팔미테이트， 아데노신 및 폴리에톡실레이티드레틴아마이드로 중에서 선택된 적어도 하나를 포함하는 광-열 안정성이 우수한 기능성 화장품. Functional cosmetics having excellent light-thermal stability comprising at least one selected from the group consisting of retinol, retinyl palmitate, adenosine, and polyethoxylatediretin amide.
【청구항 3】 [Claim 3]
제 1 항에 있어서, The method of claim 1,
상기 미백을 위한 원료 화합물이 닥나무 추출물， 알부틴, 에칠아스코빌에텔， 유용성 감초추출물, 아스코빌글루코사이드, 마그네슘아스코빌포스페이트， 나이아신아마이드， 알파-비사보롤 및 아스코빌테트라이소팔미테이트 중에서 선택된 적어도 하나를 포함하는 광-열 안정성이 우수한 기능성 화장품. The raw material for the whitening is at least one selected from among mulberry extract, arbutin, ethyl ascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, niacinamide, alpha-bisabolol and ascorbyl triisopalmitate Functional cosmetics having excellent light-thermal stability.
【청구항 4】 [Claim 4]
제 1 항에 있어서, The method of claim 1,
상기 친수계 스멕타이트 점토광물이 몬트모릴로나이트， 벤토나이트 및 핵토라이트 중에서 선택된 적어도 하나를 포함하는 광ᅳ열 안정성이 우수한 기능성 화장품. Functional cosmetics having excellent photothermal stability, wherein the hydrophilic smectite clay mineral includes at least one selected from montmorillonite, bentonite, and hacklite.
【청구항 5】 [Claim 5]
제 1 항에 있어세 In paragraph 1
상기 주름 개선 또는 미백을 위한 원료 화합물—친수계 스멕타이트 점토광물 복합체가 주름 개선 또는 미백을 위한 원료 화합물을 0.1~20 중량 %로 포함하는 광-열 안정성이 우수한 기능성 화장품. Raw material for improving wrinkles or whitening—Hydrogen-based smectite clay mineral composite is functional cosmetics excellent in light-thermal stability containing 0.1 to 20% by weight of the raw material for wrinkles improvement or whitening.
【청구항 6] 친수계 스멕타이트 점토광물에 주름 개선 또는 미백을 위한 원료 화합물이 인터칼레이션 (intercalation)된 기능성 복합체. [Claim 6] A functional complex in which a raw compound for interfacial wrinkle improvement or whitening is intercalated in a hydrophilic smectite clay mineral.
【청구항 7】 [Claim 7]
제 6 항에 있어서, The method of claim 6,
상기 주름 개선을 위한 원료 화합물은 레티놀, 레티닐팔미테이트, 아데노신 및 폴리에톡실레이티드레틴아마이드로 구성된 군쎄서 선택된 1 종 이상을 포함하는 기능성 복합체 . The raw material compound for improving wrinkles is a functional complex comprising at least one member selected from the group consisting of retinol, retinyl palmitate, adenosine and polyethoxylatedretinamide.
【청구항 8】 [Claim 8]
제 6 항에 있어서. The method of claim 6.
상기 미백을 위한 원료 화합물은 닥나무 추출물. 알부틴, 에칠아스코빌에텔, 유용성 감초추출물, 아스코빌글루코사이드， 마그네슘아스코빌포스페이트， 나이아신아마이드， 알파-비사보를 및 아스코빌테트라이소팔미테이트로 구성된 군에서 선택된 1종 이상을 포함하는 기능성 복합체. The raw compound for the whitening is extract of the mulberry. A functional complex comprising at least one member selected from the group consisting of arbutin, ethylascorbyl ether, oil-soluble licorice extract, ascorbyl glucoside, magnesium ascorbyl phosphate, niacinamide, alpha-bisabolic and ascorbyl triisopalmitate.
【청구항 9] [Claim 9]
제 6 항에 있어서， The method of claim 6,
상기 친수계 스멕타이트 점토광물이 몬트모릴로나이트, 벤토나이트 및 핵토라이트로 구성된 군에서 선택된 1종 이상을 포함하는 기능성 복합체. The functional complex of the hydrophilic smectite clay mineral containing at least one selected from the group consisting of montmorillonite, bentonite and hackolite.
【청구항 10] [Claim 10]
제 6 항에 있어서, The method of claim 6,
상기 기능성 복합체가 주름 개선 또는 미백을 위한 원료 화합물올 0.1~20 중량1 ¾로 포함하는 기능성 복합체. Functional composite is a functional composite comprising 0.1 to 20 weight 1 ¾ of the raw material compound for wrinkle improvement or whitening.
【청구항 11] [Claim 11]
(1) 친수계 스멕타이트 점토광물 0.1~1.0 중량부를 증류수 50.0 70.0 중량부에 첨가하여 호모믹서로 1，000~5,000 rpm 에서 분산한 후. 20~30°C에서 24~30 시간 교반하여 친수계 스멕타이트 점토광물의 수분산액을 수득하는 단계; (1) 0.1-1.0 parts by weight of hydrophilic smectite clay mineral was added to 50.0 70.0 parts by weight of distilled water and dispersed at 1,000-5,000 rpm with a homomixer. Stirring at 20-30 ° C for 24-30 hours to obtain an aqueous dispersion of hydrophilic smectite clay mineral;
(2) 주름 개선 또는 미백올 위한 원료 화합물 0.05-0.5 중량부를 증류수 5.0-10.0 중량부 및 알코을 용매 20.0~30.0 증량부에 용해시키는 단계; (3) 상기 (2) 단계에서 얻어진 용액을 (1) 단계에：서 수득한 수분산액에 투입하여 20 30시간 교반하여 흔합하는 단계 ; (2) dissolving 0.05-1. 5 parts by weight of distilled water and 5.0-10.0 parts by weight of distilled water and alcohol in 20.0-30.0 parts by weight of a solvent for improving wrinkles or whitening; (3) adding the solution obtained in step (2) to the aqueous dispersion obtained in step (1): stirring by mixing for 20 to 30 hours;
(4) 상기 (3) 단계에서 얻어진 흔합물을 12,000~16,000rpm 으로 원심분리한 다음.. 3~6 회 수세한후， -5으 40°C에서 65~80 시간 동결건조하는 단계를 포함하는 주름 개선 및 미백 원료-친수계 스멕타이트 층간물질 복합체의 제조방법. (4) centrifuged at 12,000-16,000 rpm for the mixture obtained in step (3) . . After washing 3-6 times, -5 to 70 ° C 65-80 hours lyophilization comprising the steps of improving wrinkles and whitening raw material-hydrophilic smectite interlayer composite manufacturing method.
【청구항 12] [Claim 12]
주름 개선 또는 피부 미백용 기능성 화장품의 제조를 위한, 제 6항 내지 제 10항 중 어느 한 항에 따른 기능성 복합체의 용도. Use of a functional complex according to any one of claims 6 to 10 for the production of functional cosmetics for wrinkle improvement or skin whitening.
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