WO2014169845A3 - 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof - Google Patents

4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof Download PDF

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Publication number
WO2014169845A3
WO2014169845A3 PCT/CN2014/075683 CN2014075683W WO2014169845A3 WO 2014169845 A3 WO2014169845 A3 WO 2014169845A3 CN 2014075683 W CN2014075683 W CN 2014075683W WO 2014169845 A3 WO2014169845 A3 WO 2014169845A3
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WO
WIPO (PCT)
Prior art keywords
pyrid
pyrazolo
dihydro
ones
preparation
Prior art date
Application number
PCT/CN2014/075683
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French (fr)
Chinese (zh)
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WO2014169845A2 (en
Inventor
魏用刚
邱关鹏
卢泳华
余彦
雷柏林
王松
黄清平
高秋
楚洪柱
祝国智
罗新峰
倪丽军
陈娅姝
邓炳初
Original Assignee
四川海思科制药有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 四川海思科制药有限公司 filed Critical 四川海思科制药有限公司
Priority to CN201480003262.1A priority Critical patent/CN105026392B/en
Publication of WO2014169845A2 publication Critical patent/WO2014169845A2/en
Publication of WO2014169845A3 publication Critical patent/WO2014169845A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)

Abstract

The present invention relates to 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, as shown in Formula (I), and to a preparation method and an application thereof; the definition of each substituent in the Formula (I) compound is the same as the definition found in the description.
PCT/CN2014/075683 2013-04-19 2014-04-18 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof WO2014169845A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201480003262.1A CN105026392B (en) 2013-04-19 2014-04-18 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201310138026 2013-04-19
CN201310138026.8 2013-04-19
CN201310372920 2013-08-23
CN201310372920.1 2013-08-23
CN201310428690.6A CN104109165A (en) 2013-04-19 2013-09-18 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives, and preparation method and application thereof
CN201310428690.6 2013-09-18

Publications (2)

Publication Number Publication Date
WO2014169845A2 WO2014169845A2 (en) 2014-10-23
WO2014169845A3 true WO2014169845A3 (en) 2014-12-11

Family

ID=51706170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/075683 WO2014169845A2 (en) 2013-04-19 2014-04-18 4,5-dihydro-pyrazolo [3, 4-c] pyrid-2-ones, preparation method and application thereof

Country Status (2)

Country Link
CN (2) CN104109165A (en)
WO (1) WO2014169845A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3064497A1 (en) * 2015-07-20 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Dimer impurities of apixaban and method to remove them
BR112018015389B1 (en) 2016-03-17 2023-12-19 F. Hoffmann-La Roche Ag 5-Ethyl-4-methyl-pyrazol-3-carboxamide derivative, its manufacturing process, oral pharmaceutical preparation and use
CN107474030B (en) * 2016-06-08 2021-03-30 首都医科大学 Warfarin-aspirin conjugates, their synthesis, antithrombotic activity and uses
CN109232596B (en) * 2018-09-05 2020-03-17 大连九信精细化工有限公司 Synthetic method of dibenzofuran carbazole
CN110143914B (en) * 2019-06-21 2022-03-29 常州恒邦药业有限公司 Preparation method of apixaban intermediate
CN117222639A (en) 2021-05-27 2023-12-12 江苏恒瑞医药股份有限公司 Quinoline amine compound, preparation method and medical application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1391575A (en) * 1998-12-23 2003-01-15 杜邦药品公司 Nitrogen containing heterobicycles as factor XA inhibitors
US20100048611A1 (en) * 2006-05-31 2010-02-25 Bayer Healthcare Ag Tetrahydropyrrolopyridine, tetrahydropyrazolopyridine, tetrahydro-imidazopyridine and tetrahydrotriazolopyridine derivatives and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152916A0 (en) * 2000-06-23 2003-06-24 Bristol Myers Squibb Co Heteroaryl-phenyl heterobicyclic factor xa inhibitors
KR100909141B1 (en) * 2001-09-21 2009-07-23 브리스톨-마이어스스퀴브컴파니 Lactam-Containing Compounds and Derivatives thereof as Factor Xa Inhibitors
TW200738672A (en) * 2001-12-10 2007-10-16 Bristol Myers Squibb Co Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
CN101065379B (en) * 2004-09-28 2011-05-11 布里斯托尔-迈尔斯斯奎布公司 Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1391575A (en) * 1998-12-23 2003-01-15 杜邦药品公司 Nitrogen containing heterobicycles as factor XA inhibitors
US20100048611A1 (en) * 2006-05-31 2010-02-25 Bayer Healthcare Ag Tetrahydropyrrolopyridine, tetrahydropyrazolopyridine, tetrahydro-imidazopyridine and tetrahydrotriazolopyridine derivatives and use thereof

Also Published As

Publication number Publication date
CN105026392A (en) 2015-11-04
CN105026392B (en) 2017-05-10
CN104109165A (en) 2014-10-22
WO2014169845A2 (en) 2014-10-23

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