WO2014195861A3 - Preparation of ticagrelor - Google Patents

Preparation of ticagrelor Download PDF

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Publication number
WO2014195861A3
WO2014195861A3 PCT/IB2014/061912 IB2014061912W WO2014195861A3 WO 2014195861 A3 WO2014195861 A3 WO 2014195861A3 IB 2014061912 W IB2014061912 W IB 2014061912W WO 2014195861 A3 WO2014195861 A3 WO 2014195861A3
Authority
WO
WIPO (PCT)
Prior art keywords
ticagrelor
preparation
intermediates
processes
present application
Prior art date
Application number
PCT/IB2014/061912
Other languages
French (fr)
Other versions
WO2014195861A2 (en
Inventor
Raghupathi Reddy Anumula
Yakambram Bojja
Sreenivasulu Kurella
Veerender Murki
Ravi Ram Chandrasekhar Elati
Venkata Annapurna Sasikala Cheemalapati
Ugandar Reddy INUGALA
Thirupathi BALUGU
Subba Reddy Peddireddy
Kavitha Charagondla
Original Assignee
Dr. Reddy’S Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy’S Laboratories Limited filed Critical Dr. Reddy’S Laboratories Limited
Priority to EP14807111.1A priority Critical patent/EP3004113A2/en
Publication of WO2014195861A2 publication Critical patent/WO2014195861A2/en
Publication of WO2014195861A3 publication Critical patent/WO2014195861A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ceramic Products (AREA)

Abstract

The present application relate to processes for preparing Ticagrelor and its intermediates.
PCT/IB2014/061912 2013-06-04 2014-06-03 Preparation of ticagrelor WO2014195861A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14807111.1A EP3004113A2 (en) 2013-06-04 2014-06-03 Preparation of ticagrelor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2434/CHE/2013 2013-06-04
IN2434CH2013 2013-06-04

Publications (2)

Publication Number Publication Date
WO2014195861A2 WO2014195861A2 (en) 2014-12-11
WO2014195861A3 true WO2014195861A3 (en) 2015-04-02

Family

ID=52008665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/061912 WO2014195861A2 (en) 2013-06-04 2014-06-03 Preparation of ticagrelor

Country Status (2)

Country Link
EP (1) EP3004113A2 (en)
WO (1) WO2014195861A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
WO2016024225A1 (en) * 2014-08-11 2016-02-18 Sun Pharmaceutical Industries Limited Stable amorphous ticagrelor and a process for its preparation
WO2016030704A1 (en) * 2014-08-30 2016-03-03 Cipla Limited Solid form of intermediate of ticagrelor
CN110183436A (en) * 2019-06-21 2019-08-30 南通常佑药业科技有限公司 A kind of preparation method of armorphous Ticagrelor
CN110684019B (en) * 2019-10-29 2020-08-18 株洲千金药业股份有限公司 Preparation method of ticagrelor intermediate oxide impurity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148888A1 (en) * 2000-06-02 2003-08-07 Ulf Larsson Novel triazolo pyrimidine compounds
US7265124B2 (en) * 2000-06-02 2007-09-04 Astrazeneca Ab Cristalline and amorphous form of a triazolo (4,5-D) pyridimine compound

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148888A1 (en) * 2000-06-02 2003-08-07 Ulf Larsson Novel triazolo pyrimidine compounds
US7265124B2 (en) * 2000-06-02 2007-09-04 Astrazeneca Ab Cristalline and amorphous form of a triazolo (4,5-D) pyridimine compound

Also Published As

Publication number Publication date
WO2014195861A2 (en) 2014-12-11
EP3004113A2 (en) 2016-04-13

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