WO2014073069A1 - 光生体計測装置 - Google Patents
光生体計測装置 Download PDFInfo
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- WO2014073069A1 WO2014073069A1 PCT/JP2012/078949 JP2012078949W WO2014073069A1 WO 2014073069 A1 WO2014073069 A1 WO 2014073069A1 JP 2012078949 W JP2012078949 W JP 2012078949W WO 2014073069 A1 WO2014073069 A1 WO 2014073069A1
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- 238000005259 measurement Methods 0.000 title claims abstract description 280
- 230000000258 photobiological effect Effects 0.000 title claims abstract description 11
- 239000000523 sample Substances 0.000 claims abstract description 73
- 238000000034 method Methods 0.000 claims abstract description 24
- 210000004761 scalp Anatomy 0.000 claims abstract description 22
- 230000003287 optical effect Effects 0.000 claims description 44
- 230000005540 biological transmission Effects 0.000 claims description 21
- 238000004148 unit process Methods 0.000 claims 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 10
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 9
- 210000004556 brain Anatomy 0.000 description 9
- 108010002255 deoxyhemoglobin Proteins 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 108010054147 Hemoglobins Proteins 0.000 description 7
- 102000001554 Hemoglobins Human genes 0.000 description 7
- 230000002123 temporal effect Effects 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000007177 brain activity Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003727 cerebral blood flow Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7278—Artificial waveform generation or derivation, e.g. synthesising signals from measured signals
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/742—Details of notification to user or communication with user or patient ; user input means using visual displays
- A61B5/7435—Displaying user selection data, e.g. icons in a graphical user interface
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
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- A—HUMAN NECESSITIES
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
Definitions
- the present invention relates to an optical biometric apparatus that measures brain activity non-invasively.
- optical biological measurement that can be used as an oxygen monitor for diagnosing whether or not a living tissue is normal by measuring temporal changes in blood flow in each part of the brain and changes in oxygen supply over time Relates to the device.
- an optical brain functional imaging apparatus that performs noninvasive measurement using light.
- a near-red light having three different wavelengths ⁇ 1 , ⁇ 2 , and ⁇ 3 (for example, 780 nm, 805 nm, and 830 nm) is obtained by a light transmission probe arranged on the scalp surface of the subject.
- the light-receiving probe arranged on the scalp surface changes the intensity of the near-infrared light of each wavelength ⁇ 1 , ⁇ 2 , ⁇ 3 (received light amount information) ⁇ A ( ⁇ 1 ), ⁇ A ( ⁇ 2 ), and ⁇ A ( ⁇ 3 ) are detected.
- concentration change / optical path length product ([oxyHb] + [deoxyHb]) of total hemoglobin is calculated from the concentration change / optical path length product [oxyHb] of oxyhemoglobin and the concentration change / optical path length product [deoxyHb] of deoxyhemoglobin. Calculated.
- ⁇ A ( ⁇ 1 ) E O ( ⁇ 1 ) ⁇ [oxyHb] + E d ( ⁇ 1 ) ⁇ [deoxyHb] (1)
- ⁇ A ( ⁇ 2 ) E O ( ⁇ 2 ) ⁇ [oxyHb] + E d ( ⁇ 2 ) ⁇ [deoxyHb] (2)
- ⁇ A ( ⁇ 3 ) E O ( ⁇ 3 ) ⁇ [oxyHb] + E d ( ⁇ 3 ) ⁇ [deoxyHb] (3)
- E O ( ⁇ m) is an absorbance coefficient of oxyhemoglobin in light having a wavelength ⁇ m
- E d ( ⁇ m) is an absorbance coefficient of deoxyhemoglobin in light having a wavelength ⁇ m.
- oxyhemoglobin concentration change / optical path length product [oxyHb], deoxyhemoglobin concentration change / optical path length product [deoxyHb] and total hemoglobin concentration change / optical path for multiple measurement sites in the brain For example, a near-infrared spectrometer is used (for example, see Patent Document 1).
- a holder transmission / reception unit
- FIG. 1 A near-infrared spectrometer
- FIG. 2 is a plan view showing an example of a holder into which 15 light transmitting probes and 15 light receiving probes are inserted.
- the light-transmitting probes 12 T1 to 12 T15 and the light-receiving probes 13 R1 to 13 R15 are alternately arranged in five in the vertical direction and six in the horizontal direction.
- the interval between the light transmitting probes 12 T1 to 12 T15 and the light receiving probes 13 R1 to 13 R15 is 30 mm.
- FIG. 7 is a diagram showing a display screen on which measurement data X n (t), Y n (t), and Z n (t) relating to 49 measurement sites are arranged.
- the vertical axis in the measurement data indicates the concentration change / optical path length product [oxyHb], and the horizontal axis indicates time t.
- the light transmitting probe 12 irradiates each midpoint of the line connecting the light transmitting probes 12 T1 to 12 T15 and the light receiving probes 13 R1 to 13 R15 at the shortest distance.
- the measurement data obtained when the received light is detected by the light receiving probe 13 are arranged and displayed so as to be arranged.
- the measurement data when the light emitted from the light transmission probe 12 T1 is detected by the light reception probe 13 R1 is arranged at the upper left as the measurement data image # 1 of the channel number 1, and the light transmission probe 12 T2
- the measurement data when the light irradiated from the light detection probe 13 R1 is detected is arranged on the right side of the measurement data image # 1 as the measurement data image # 2 of the channel number 2 and irradiated from the light transmission probe 12 T1 .
- measurement data obtained while detecting light-receiving probe 13 R4 is, as will be positioned at the lower left of the measurement data image # 1 as measured data image # 6 of channel numbers 6, 49 pieces of the measurement data image # 1 to # 49 are arranged in alignment.
- the displayed 49 measurement data # 1 to # 49 include changes in skin blood flow, heart rate variability, pulsation / respiration, etc. in addition to signals based on blood flow accompanying brain activation. A signal based on is also superimposed. Therefore, various processes are performed on the measurement data # 1 to # 49 so that it is possible to easily examine whether or not a medical condition such as cerebral ischemia has occurred.
- an addition process of adding four measurement data selected from 49 measurement data # 1 to # 49, or 38 measurements selected from 49 measurement data # 1 to # 49 Statistical processing for calculating statistical data from data, enlarged display processing for enlarging and displaying four measurement data selected from among the 49 measurement data # 1 to # 49, and 49 measurement data # 1 to ##
- Data output processing for displaying four measurement data selected from 49 in a numerical table is executed.
- FIG. 8 is a diagram showing an input screen for processing 49 pieces of measurement data # 1 to # 49.
- a space for entering the channel number of the measurement data to be added a space for entering the channel number of the measurement data to be statistically processed, and a channel number of the measurement data to be enlarged and displayed are entered.
- a space for inputting a channel number of measurement data to be processed for data output is displayed at the bottom of the input screen.
- a doctor or the like observes the display screen shown in FIG. 7, records the channel number of measurement data to be processed in a notebook, calls the input screen shown in FIG. 8, and stores the measurement data in the space of the input screen. The user entered the channel number and touched the “OK” button.
- an object of the present invention is to provide an optical biometric device that can easily execute processing of measurement data while observing the measurement data.
- the optical biometric device of the present invention made to solve the above problems includes a plurality of light transmitting probes arranged on the surface of the subject's scalp and a plurality of light receiving probes arranged on the surface of the scalp. And the light transmitting probe irradiates the scalp surface with light and controls the light receiving probe to detect the light emitted from the scalp surface.
- a transmission / reception control unit for acquiring the received light amount information, an arithmetic unit for acquiring the M measurement data based on the M received light amount information, and N selected from the M measurement data
- a measurement data display control unit that displays a display screen on which the measurement data is arranged and a processing unit that processes at least one measurement data selected from among the N measurement data.
- the measurement data table In the display screen displayed by the control unit, measured by the data image is selected, as determined measured data processed by the processing unit, the processed measurement data is characterized in that it is displayed.
- the “measurement data” may be the temporal change of the received light amount information detected by the light receiving probe itself, the temporal change of the oxyhemoglobin concentration calculated from the received light amount information, the temporal change of the deoxyhemoglobin concentration, It may be a change over time in the total hemoglobin concentration, the received light amount information itself at a certain time, the oxyhemoglobin concentration at a certain time, the deoxyhemoglobin concentration at a certain time, or the total hemoglobin concentration at a certain time. .
- the measurement data display control unit displays a display screen on which N ( ⁇ M) measurement data are arranged. Then, a doctor or the like observes the display screen and selects measurement data to be processed on the display screen. Therefore, the doctor or the like does not need to store the channel number of the measurement data to be processed, and does not need to perform a switching operation for opening another screen as in the past.
- the optical biological measurement apparatus of the present invention it is possible to easily execute processing of measurement data while observing the measurement data.
- the doctor or the like can consider the relative positional relationship of the measurement data and the quality of the measurement data, and can further prevent erroneous operations such as selection mistakes.
- the optical biometric apparatus of the present invention includes a plurality of light transmitting probes disposed on the surface of the subject's scalp, and a light transmitting / receiving unit having a plurality of light receiving probes disposed on the surface of the scalp.
- the light-transmitting probe irradiates light on the scalp surface, and the light-receiving probe is controlled to detect light emitted from the scalp surface, thereby acquiring M pieces of received light amount information regarding M measurement sites.
- a control unit for transmitting and receiving light, an arithmetic unit for acquiring M measurement data based on M received light amount information, and N measurement data selected from the M measurement data are arranged.
- An optical biometric device comprising a measurement data display control unit for displaying a display screen and a processing unit for processing at least one measurement data selected from N pieces of measurement data, wherein the measurement data display control Part is N measurement data Displaying a display screen on which N measurement data buttons corresponding to the array positions are arranged, and selecting the measurement data button on the display screen displayed by the measurement data display control unit, the processing unit The measurement data to be processed is determined, and the processed measurement data is displayed.
- the optical biological measurement apparatus of the present invention it is possible to easily execute measurement data processing.
- the doctor or the like can consider the relative positional relationship of the measurement data, and can further prevent erroneous operations such as selection mistakes.
- the display method of the measurement data button may be changed. According to the optical biometric apparatus of the present invention, the selected measurement data can be easily grasped.
- the display method changes a color of the measurement data image or the measurement data button, or adds a mark on the measurement data image or the measurement data button. It may be made to be.
- the processing unit A plurality of selected measurement data may be processed.
- the processing unit adds a plurality of measurement data, adds a plurality of measurement data, calculates a statistical data from the plurality of measurement data, and displays an enlarged display of the measurement data. You may make it perform at least 1 process selected from the process group which consists of a process and the data output process which displays measurement data by a numerical table.
- FIG. 1 is a block diagram showing a schematic configuration of an optical biological measurement apparatus that is an embodiment of the present invention.
- the top view which shows an example of the holder in which 15 light transmission probes and 15 light reception probes are inserted.
- the figure which shows the display screen on which the measurement data regarding 49 measurement parts were arranged.
- the figure which shows the display screen from which 38 measurement data were selected.
- the figure which shows the display screen on which the measurement data regarding 49 measurement parts were arranged.
- FIG. 1 is a block diagram showing a schematic configuration of an optical biological measuring apparatus according to an embodiment of the present invention.
- the optical biological measurement apparatus 1 includes a light source 2 that emits light, a light source driving mechanism 4 that drives the light source 2, a light detector 3 that detects light, an A / D (A / D converter) 5, and a light transmission / reception unit.
- a display device 26 and a keyboard 27 are examples of the optical biological measurement apparatus.
- the light source drive mechanism 4 drives the light source 2 by a drive signal input from the light transmission / reception controller 21.
- the light source 2 is, for example, a semiconductor laser LD1, LD2, or LD3 that can emit near-infrared light of three different wavelengths ⁇ 1 , ⁇ 2 , and ⁇ 3 .
- the photodetector 3 is, for example, a photomultiplier tube or the like, and individually detects near-infrared light received by the 15 light-receiving probes 13 R1 to 13 R15 , thereby obtaining 15 light-receiving amount information ⁇ A ( ⁇ 1 ), ⁇ A ( ⁇ 2 ), ⁇ A ( ⁇ 3 ) are output to the light transmission / reception controller 21 via the A / D 5.
- 15 light transmitting probes 12 T1 to 12 T15 and 15 light receiving probes 13 R1 to 13 R15 are inserted.
- the light transmitting probes 12 T1 to 12 T15 and the light receiving probes 13 R1 to 13 R15 are arranged in a square lattice pattern so as to alternate in the row direction and the column direction. At this time, the interval between the light transmitting probes 12 T1 to 12 T15 and the light receiving probes 13 R1 to 13 R15 is 30 mm.
- the light transmission / reception control unit 21 outputs a drive signal for transmitting light to one light transmission probe 12 at a predetermined time to the light source driving mechanism 4 and also receives light reception amount information ⁇ A n (received by the light reception probe 13.
- first 5 milliseconds, to the light-sending probe 12 T1 is sending a wavelength 780nm light
- the next 5 milliseconds is sending the light of wavelength 805nm to the light-sending probe 12 T1
- the next 5 One light is transmitted at a predetermined timing so that light having a wavelength of 830 nm is transmitted to the light transmitting probe 12 T1 in milliseconds, and light having a wavelength of 780 nm is transmitted to the light transmitting probe 12 T2 in the next 5 milliseconds.
- Light is sequentially transmitted to the light transmission probes 12 T1 to 12 T15 .
- the light reception amount information is detected by the 15 light reception probes 13 R1 to 13 R15.
- the received light amount information of the predetermined light receiving probes 13 R1 to 13 R15 (adjacent to the light transmitting probe irradiated with the light) detected in step 1 is stored in the memory 25. Accordingly, a total of 49 pieces of received light amount information ⁇ A n ( ⁇ 1 ), ⁇ A n ( ⁇ 2 ), and ⁇ A n ( ⁇ 3 ) are collected.
- the measurement data display control unit 23 performs control to display the measurement data # 1 to # 49 calculated by the calculation unit 22.
- FIG. 3 is a diagram showing a display screen on which measurement data X n (t), Y n (t), and Z n (t) relating to 49 measurement sites are arranged.
- the background color of the measurement data images # 1 to # 49 is white.
- an “OK” button, a “cancel” button, and an “information clear” button are displayed at the bottom of the display screen.
- an “addition process” button, a “statistical process” button, an “enlarged display process” button, and a “data output process” button are displayed.
- the processing unit 24 performs control to process and display the selected measurement data when a measurement data image is selected from among the 49 measurement data images # 1 to # 49 on the display screen shown in FIG. Do.
- FIG. 4 is a diagram showing a display screen on which 38 pieces of measurement data # 1, # 6, # 7, and # 12 are selected. For example, the doctor or the like observes the display screen shown in FIG. 3 and 11 pieces of measurement data # 39, # 40, # 41, # 42, # 43, # 44, # 45, # 46, # 47, # 47 When you want to execute statistical processing to calculate statistical data from 38 measurement data except 48 and # 49, touch the “Statistical processing” button with your finger or touch pen and touch the measurement data image # 1.
- doctor and the like observe the display screen shown in FIG. 3 and want to execute addition processing for adding measurement data # 1, measurement data # 6, measurement data # 7, and measurement data # 12.
- ”Button and touching measurement data image # 1 makes the background color of measurement data image # 1 gray
- touching measurement data image # 6 makes the background color of measurement data image # 6 gray.
- the processing unit 24 displays the added measurement data obtained by adding the measurement data # 1, the measurement data # 6, the measurement data # 7, and the measurement data # 12.
- the doctors or the like observe the display screen shown in FIG. 3 and execute an enlarged display process for enlarging and displaying the measurement data # 1, the measurement data # 6, the measurement data # 7, and the measurement data # 12.
- Touching the “Enlarged display processing” button and touching the measurement data image # 1 makes the background color of the measurement data image # 1 gray
- touching the measurement data image # 6 makes the background of the measurement data image # 6
- Touching measurement data image # 7 makes the color gray
- touching measurement data image # 12 makes the background color gray.
- Touching measurement data image # 12 makes the background color of measurement data image # 12 gray.
- Touch the “OK” button Thereby, the processing unit 24 displays the enlarged measurement data obtained by enlarging and displaying the measurement data # 1, the measurement data # 6, the measurement data # 7, and the measurement data # 12.
- doctors or the like observe the display screen shown in FIG. 3 and want to execute data output processing for displaying measurement data # 1, measurement data # 6, measurement data # 7, and measurement data # 12 in a numerical table.
- Touching the “Data output processing” button and touching the measurement data image # 1 makes the background color of the measurement data image # 1 gray, and touching the measurement data image # 6 causes the measurement data image # 6 to touch the measurement data image # 6.
- the background color becomes gray
- the measurement data image # 7 touches the background color of the measurement data image # 7, and the measurement data image # 12 touches the background color of the measurement data image # 12. It turns gray and touches the “OK” button.
- the processing unit 24 displays the measurement data # 1, the measurement data # 6, the measurement data # 7, and the measurement data # 12 in a numerical table.
- the optical biological measuring apparatus 1 it is possible to easily execute measurement data processing while observing 49 pieces of measurement data # 1 to # 49. At this time, the doctor or the like can consider the relative positional relationship of the measurement data and the quality of the measurement data, and can further prevent erroneous operations such as selection mistakes.
- the measurement data display control unit 23 changes the oxyhemoglobin concentration change / optical path length product [oxyHb] with time (measurement data) X n (t), deoxyhemoglobin concentration change.
- X n (t) time (measurement data)
- Y n (t) deoxyhemoglobin concentration change
- the concentration change and optical path length product [oxyHb] of oxyhemoglobin at a certain time is expressed in color.
- FIG. 5 is a diagram showing a display screen in which measurement data X n (t) relating to 49 measurement sites is expressed as a contour map, and four measurement data # 1, # 6, # 7, and # 12 are selected. is there.
- FIG. 6 is a diagram showing a display screen in which 49 measurement data buttons are arranged and 4 measurement data buttons are selected.
- the present invention can be used for an optical biometric device that measures brain activity non-invasively.
- Optical biological measurement device 12 Light transmission probe 13: Light reception probe 21: Light transmission / reception control unit 22: Calculation unit 23: Measurement data display control unit 24: Processing unit 30: Holder (transmission / reception unit)
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Abstract
Description
そして、このようにして得られた受光量情報ΔA(λ1)、ΔA(λ2)、ΔA(λ3)から、脳血流中のオキシヘモグロビンの濃度変化・光路長積[oxyHb]と、デオキシヘモグロビンの濃度変化・光路長積[deoxyHb]とを求めるために、例えば、Modified Beer Lambert則を用いて関係式(1)(2)(3)に示す連立方程式を作成して、この連立方程式を解いている。さらには、オキシヘモグロビンの濃度変化・光路長積[oxyHb]と、デオキシヘモグロビンの濃度変化・光路長積[deoxyHb]とから総ヘモグロビンの濃度変化・光路長積([oxyHb]+[deoxyHb])を算出している。
ΔA(λ1)=EO(λ1)×[oxyHb]+Ed(λ1)×[deoxyHb]・・・(1)
ΔA(λ2)=EO(λ2)×[oxyHb]+Ed(λ2)×[deoxyHb]・・・(2)
ΔA(λ3)=EO(λ3)×[oxyHb]+Ed(λ3)×[deoxyHb]・・・(3)
なお、EO(λm)は、波長λmの光におけるオキシヘモグロビンの吸光度係数であり、Ed(λm)は、波長λmの光におけるデオキシヘモグロビンの吸光度係数である。
このような近赤外分光分析計においては、15個の送光プローブと15個の受光プローブとを所定の配列で被検者の頭皮表面に接触させるために、ホルダ(送受光部)が使用される。図2は、15個の送光プローブと15個の受光プローブとが挿入されるホルダの一例を示す平面図である。
送光プローブ12T1~12T15と受光プローブ13R1~13R15とは、縦方向に5個と横方向に6個とに交互となるように配置されている。このとき、送光プローブ12T1~12T15と受光プローブ13R1~13R15との間の間隔は、30mmとなっている。これにより、脳の49箇所の測定部位に関する受光量情報ΔAn(λ1)、ΔAn(λ2)、ΔAn(λ3)(n=1、2、・・・、49)を得ている。
そして、49個の測定データXn(t)、Yn(t)、Zn(t)が表示されている。このとき、図2に示した平面図において、送光プローブ12T1~12T15と受光プローブ13R1~13R15とを最短距離で結んだ線の各中点に、その送光プローブ12から照射させた光を、その受光プローブ13で検出させたときに得られた測定データが配置されるように整列して表示されている。具体的には、送光プローブ12T1から照射させた光を受光プローブ13R1で検出させたときの測定データが、チャンネル番号1の測定データ画像#1として左上に配置され、送光プローブ12T2から照射させた光を受光プローブ13R1で検出させたときの測定データが、チャンネル番号2の測定データ画像#2として測定データ画像#1の右に配置され、送光プローブ12T1から照射させた光を受光プローブ13R4で検出させたときの測定データが、チャンネル番号6の測定データ画像#6として測定データ画像#1の左下に配置されるように、49個の測定データ画像#1~#49が整列して配置されている。
そこで、脳虚血等の病状が生じているか否かを容易に診察することができるように、測定データ#1~#49に対して様々な処理を実行している。例えば、49個の測定データ#1~#49の内から選択された4個の測定データを加算する加算処理や、49個の測定データ#1~#49の内から選択された38個の測定データから統計データを算出する統計処理や、49個の測定データ#1~#49の内から選択された4個の測定データを拡大表示する拡大表示処理や、49個の測定データ#1~#49の内から選択された4個の測定データを数値表で表示するデータ出力処理等を実行している。
そこで、本発明は、測定データを観察しながら、測定データの処理を容易に実行することができる光生体計測装置を提供することを目的とする。
また、本発明の光生体計測装置は、被検者の頭皮表面上に配置される複数個の送光プローブと、当該頭皮表面上に配置される複数個の受光プローブとを有する送受光部と、前記送光プローブが頭皮表面に光を照射するとともに、前記受光プローブが頭皮表面から放出される光を検出するように制御することで、M個の測定部位に関するM個の受光量情報を取得する送受光用制御部と、M個の受光量情報に基づいて、M個の測定データを取得する演算部と、M個の測定データの内から選択されたN個の測定データが配列された表示画面を表示する測定データ表示制御部と、N個の測定データの内から選択された少なくとも1個の測定データを処理する処理部とを備える光生体計測装置であって、前記測定データ表示制御部は、N個の測定データの配列位置に対応するN個の測定データボタンが配列された表示画面を表示し、前記測定データ表示制御部で表示された表示画面上において、前記測定データボタンが選択されることにより、前記処理部で処理される測定データが決定され、処理された測定データが表示されることを特徴としている。
本発明の光生体計測装置によれば、選択した測定データを容易に把握することができる。
そして、本発明の光生体計測装置においては、前記測定データ表示制御部で表示された表示画面上において、複数個の前記測定データ画像又は前記測定データボタンが選択された後で、前記処理部は、選択された複数個の測定データを処理するようにしてもよい。
光検出器3は、例えば光電子増倍管等であり、15個の受光プローブ13R1~13R15で受光した近赤外光を個別に検出することにより、15個の受光量情報ΔA(λ1)、ΔA(λ2)、ΔA(λ3)を、A/D5を介して送受光用制御部21に出力する。
表示画面には、49個の測定データ画像#1~#49が整列して表示されている。また、各測定データ画像#1~#49の左上部には、測定データが得られた送光プローブ12と受光プローブ13との関係を示すチャンネル番号n(n=1,2,・・・,49)が表示されている。そして、測定データ画像#1~#49の背景の色は、白色となっている。
なお、使用方法については後述するが、表示画面の下部には、「OK」ボタンと、「キャンセル」ボタンと、「情報クリア」ボタンとが表示されている。そして、表示画面の右部には、「加算処理」ボタンと、「統計処理」ボタンと、「拡大表示処理」ボタンと、「データ出力処理」ボタンとが表示されている。
例えば、医師等は、図3に示す表示画面を観察して、11個の測定データ#39、#40、#41、#42、#43、#44、#45、#46、#47、#48、#49を除く38個の測定データから統計データを算出する統計処理を実行したいときには、「統計処理」ボタンを、指やタッチペン等でタッチし、測定データ画像#1をタッチすることで測定データ画像#1の背景の色が灰色となり測定データ画像#2をタッチすることで測定データ画像#2の背景の色が灰色となるように、38個の測定データ画像をタッチすることで38個の測定データ画像の背景の色が灰色となる(図4参照)。そして、「OK」ボタンをタッチする。これにより、処理部24は、11個の測定データ#39、#40、#41、#42、#43、#44、#45、#46、#47、#48、#49を除く38個の測定データから統計データを算出して表示する。
このとき、測定データ画像#39を誤って選択したときには、「キャンセル」ボタンをタッチし、測定データ画像#39をタッチすることで測定データ画像#39の背景の色が白色となり、測定データ画像#39の選択が取り消される。また、例えば測定データ画像#7をタッチした後に、統計処理を実行する必要がなくなったときには、「情報クリア」ボタンをタッチすることで測定データ画像#1~#7の背景の色が白色となり、全ての選択が取り消される
(1)上述した光生体計測装置1では、測定データ表示制御部23は、オキシヘモグロビンの濃度変化・光路長積[oxyHb]の経時変化(測定データ)Xn(t)、デオキシヘモグロビンの濃度変化・光路長積[deoxyHb]の経時変化(測定データ)Yn(t)及び総ヘモグロビンの濃度変化・光路長積([oxyHb]+[deoxyHb])の経時変化(測定データ)Zn(t)(n=1,2,・・・,49)を測定データ#1~#49として表示する構成を示したが、ある時間におけるオキシヘモグロビンの濃度変化・光路長積[oxyHb] を色で表現して、測定データとして表示する構成としてもよい。図5は、49箇所の測定部位に関する測定データXn(t)が等高線マップとして表現され、4個の測定データ#1、#6、#7、#12が選択された表示画面を示す図である。
12: 送光プローブ
13: 受光プローブ
21: 送受光用制御部
22: 演算部
23: 測定データ表示制御部
24: 処理部
30: ホルダ(送受光部)
Claims (6)
- 被検者の頭皮表面上に配置される複数個の送光プローブと、当該頭皮表面上に配置される複数個の受光プローブとを有する送受光部と、
前記送光プローブが頭皮表面に光を照射するとともに、前記受光プローブが頭皮表面から放出される光を検出するように制御することで、M個の測定部位に関するM個の受光量情報を取得する送受光用制御部と、
M個の受光量情報に基づいて、M個の測定データを取得する演算部と、
M個の測定データの内から選択されたN個の測定データが配列された表示画面を表示する測定データ表示制御部と、
N個の測定データの内から選択された少なくとも1個の測定データを処理する処理部とを備える光生体計測装置であって、
前記測定データ表示制御部で表示された表示画面上において、測定データ画像が選択されることにより、前記処理部で処理される測定データが決定され、処理された測定データが表示されることを特徴とする光生体計測装置。 - 被検者の頭皮表面上に配置される複数個の送光プローブと、当該頭皮表面上に配置される複数個の受光プローブとを有する送受光部と、
前記送光プローブが頭皮表面に光を照射するとともに、前記受光プローブが頭皮表面から放出される光を検出するように制御することで、M個の測定部位に関するM個の受光量情報を取得する送受光用制御部と、
M個の受光量情報に基づいて、M個の測定データを取得する演算部と、
M個の測定データの内から選択されたN個の測定データが配列された表示画面を表示する測定データ表示制御部と、
N個の測定データの内から選択された少なくとも1個の測定データを処理する処理部とを備える光生体計測装置であって、
前記測定データ表示制御部は、N個の測定データの配列位置に対応するN個の測定データボタンが配列された表示画面を表示し、
前記測定データ表示制御部で表示された表示画面上において、前記測定データボタンが選択されることにより、前記処理部で処理される測定データが決定され、処理された測定データが表示されることを特徴とする光生体計測装置。 - 前記測定データ表示制御部で表示された表示画面上において、前記測定データ画像又は前記測定データボタンが選択されることにより、選択された前記測定データ画像又は前記測定データボタンの表示方法を変化させることを特徴とする請求項1又は請求項2に記載の光生体計測装置。
- 前記表示方法は、前記測定データ画像又は前記測定データボタンの色を変化させるか、或いは、前記測定データ画像又は前記測定データボタン上に印を付加することを特徴とする請求項3に記載の光生体計測装置。
- 前記測定データ表示制御部で表示された表示画面上において、複数個の前記測定データ画像又は前記測定データボタンが選択された後で、前記処理部は、選択された複数個の測定データを処理することを特徴とする請求項1~請求項4のいずれか1項に記載の光生体計測装置。
- 前記処理部は、複数個の測定データを加算する加算処理、複数個の測定データから統計データを算出する統計処理、測定データを拡大表示する拡大表示処理、及び、測定データを数値表で表示するデータ出力処理からなる処理群から選択される少なくとも一つの処理を実行することを特徴とする請求項1~請求項5のいずれか1項に記載の光生体計測装置。
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