WO2014065622A1 - Dispositif d'injection de résine durcissant aux rayons ultraviolets pour le traitement d'un anévrisme - Google Patents

Dispositif d'injection de résine durcissant aux rayons ultraviolets pour le traitement d'un anévrisme Download PDF

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Publication number
WO2014065622A1
WO2014065622A1 PCT/KR2013/009546 KR2013009546W WO2014065622A1 WO 2014065622 A1 WO2014065622 A1 WO 2014065622A1 KR 2013009546 W KR2013009546 W KR 2013009546W WO 2014065622 A1 WO2014065622 A1 WO 2014065622A1
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WO
WIPO (PCT)
Prior art keywords
curable resin
light source
catheter
aneurysm
disposed
Prior art date
Application number
PCT/KR2013/009546
Other languages
English (en)
Korean (ko)
Inventor
김준원
강동훈
박재찬
박우성
Original Assignee
포항공과대학교 산학협력단
경북대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020130126838A external-priority patent/KR101546153B1/ko
Application filed by 포항공과대학교 산학협력단, 경북대학교 산학협력단 filed Critical 포항공과대학교 산학협력단
Publication of WO2014065622A1 publication Critical patent/WO2014065622A1/fr
Priority to US14/696,298 priority Critical patent/US20150250483A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A61B17/12118—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm for positioning in conjunction with a stent

Definitions

  • the technical field to which the present invention pertains relates to a UV curable resin injector. Specifically, the present invention relates to a UV curable resin injector for treating aneurysms.
  • Cerebral aneurysm a circulatory disease caused by an aneurysm, is a disease in which the weak part of the wall of the blood vessel is swollen in the shape of a cortex. subarachnoid hemorrhage).
  • Cerebral aneurysms can be treated in two ways: surgical and endovascular surgery.
  • Surgical operation is mainly performed by opening the skull and snapping the aneurysm neck with a clip.
  • Intravascular surgery is performed by inserting a catheter into an aneurysm and filling an embolic material into the aneurysm.
  • ISAT International Subarachnoid Aneurysm Trial
  • the most widely used intravascular aneurysm treatment method is using coils.
  • a frame suitable for the size of an aneurysm is selected and inserted into the aneurysm through a catheter.
  • the small coils are packed to block the inside of the aneurysm from blood flow.
  • the inserted coil may not be able to stay in the aneurysm and come out of the blood vessel.
  • a balloon or stent may be used or two coils may be used at the same time.
  • assistive procedures have been developed.
  • CT computed tomography
  • MRI magnetic resonance imaging
  • US Patent No. 6,576,000 discloses a technique of applying a UV curable resin to an inner space of an aneurysm and irradiating it with UV light.
  • the UV-transmitting tube and the UV-curable resin flow through the catheter in a ring shape, the UV-curable resin hardens by the UV light during the passage, so that the UV-curable resin does not fill the space inside the aneurysm well.
  • the catheter should have a diameter small enough to be inserted into the blood vessel, and it is also a problem that it is not easy to manufacture a catheter formed in a circular shape with a tube and a UV curable resin that transmits UV light therein to a small diameter.
  • a UV curable resin injector for treating aneurysms aims to solve the following problems.
  • a UV curable resin injector for treating aneurysms is a catheter, a light source disposed inside the catheter for transmitting UV light, and a connection pipe disposed to be spaced apart from the light source inside the catheter to deliver UV cured resin. And the light source is formed independently of the connector.
  • the light source of the UV curable resin injector for treating an aneurysm according to the present invention is formed of an optical fiber, one end of the light source is projected to one end of the catheter, the other end of the light source is preferably disposed UV light.
  • an optical fiber insertion groove is formed in communication with the light source, and the light source disposed in the optical fiber insertion groove is slidably disposed in the optical fiber insertion groove When pressing the light source toward the catheter, one end of the light source is preferably extended from one end of the catheter.
  • the light source of the UV curable resin injector for treating an aneurysm is rotatably disposed in the optical fiber insertion groove.
  • a nozzle is formed at one end of the connecting tube of the UV curable resin injector for treating an aneurysm according to the present invention, and the other end of the connecting tube is preferably in communication with the UV resin supply unit.
  • UV resin supply portion of the UV curable resin injector for treating aneurysms according to the present invention is preferably a pump device.
  • UV barrier material is preferably coated on the outer surface of the connection tube or catheter of the UV curable resin injector for treating aneurysms according to the present invention.
  • a plurality of curable resin injection holes are formed at one end of the nozzle of the UV curable resin injector for treating an aneurysm according to the present invention.
  • each of the curable resin injection holes of the UV curable resin injector for treating an aneurysm according to the present invention has a different diameter.
  • the balloon is disposed on one side of the catheter of the UV curable resin injector for treating aneurysm according to the present invention, the liquid injection tube is in communication with the balloon to supply and expand the liquid between the one end and the other side of the catheter is disposed desirable.
  • One side of the catheter of the UV curable resin injector for treating an aneurysm according to the present invention is preferably arranged inside or outside the stent a plurality of corrugated modules to form a network shape.
  • a coupling member disposed between the light source and the connection tube of the UV curable resin injector for treating an aneurysm according to the present invention for coupling the light source and the connection tube.
  • a first blocking member disposed on the outer circumferential surface of the connecting tube of the UV curable resin injector for treating an aneurysm according to the present invention, and blocking the UV light irradiated to the connecting tube.
  • the outer peripheral surface of one end of the connection pipe of the UV curable resin injection device for treating an aneurysm according to the present invention further includes a second blocking member for blocking UV light emitted from the connection pipe.
  • a reflective surface is formed at one end of the light source of the UV curable resin injector for treating an aneurysm according to the present invention, and the reflective surface is inclined such that UV light is reflected in a direction perpendicular to the longitudinal direction of the connection pipe.
  • the reflective surface of the UV curable resin injector for treating an aneurysm according to the present invention is preferably formed by a reflective coating.
  • a plurality of micro protrusions are formed on the end face and the outer circumferential surface of one end of the connection pipe of the UV curable resin injector for treating aneurysms according to the present invention.
  • the UV curable resin injector for treating aneurysms according to the present invention can be cured at the same time as ejecting the embolic material delivered to the affected part in a liquid state, thereby simplifying the surgical procedure, reducing the operating time, and improving the treatment precision. It can be effective.
  • the UV curable resin injector for treating aneurysm according to the present invention can be produced in a small size that can pass through small blood vessels while including a light source and a nozzle at the same time, thereby broadening the scope of treatment It works.
  • the UV curable resin injection device for treating aneurysms according to the present invention can be actively applied to various situations, and the above characteristics have the effect of greatly increasing the effect of the aneurysm treatment and are performed using a non-metallic material. There is an effect that does not generate interference.
  • FIG. 1 is a front view of a UV curable resin injector for treating an aneurysm according to a first embodiment of the present invention.
  • FIG. 2 is a cross-sectional view taken along line II-II of FIG. 1.
  • FIG. 3 is a side cross-sectional view of the catheter shown in FIG. 1.
  • FIG. 4 is a plan view of the nozzle shown in FIG. 1.
  • FIG. 5 is a front view of the UV curable resin injector for treating an aneurysm according to a second embodiment of the present invention.
  • FIG. 6 is a cross-sectional view taken along line VI-VI of FIG. 5.
  • Figure 7 is a partial perspective view of the UV curable resin injector for treating aneurysm according to a third embodiment of the present invention.
  • FIG. 8 is a longitudinal sectional view of the catheter in the UV curable resin injector for treating an aneurysm according to a fourth embodiment of the present invention.
  • FIG. 9 is a cross-sectional view of the catheter in the UV curable resin injector for treating an aneurysm according to a fourth embodiment of the present invention.
  • UV curable resin injector for treating aneurysm according to the present invention.
  • FIG. 1 is a front view of the UV curable resin injector for treating aneurysm according to the present invention
  • Figure 2 is a cross-sectional view taken along the line II-II of Figure 1
  • Figure 3 is a side cross-sectional view of the catheter shown in Figure 1
  • Figure 4 Is a plan view of the nozzle shown in FIG. 1.
  • UV curable resin injector for treating aneurysms is used in the treatment for the treatment of cerebral aneurysms or aneurysms, as shown in Figure 1 is disposed inside the catheter 100, and the catheter 100 It includes a light source 200 for transmitting the UV light and the connection tube 320 is disposed spaced apart from the light source 200 in the catheter 100 to deliver the UV curable resin.
  • the light source 200 is formed independently of the connection pipe 320.
  • the UV curable resin is injected into the aneurysm through the connecting pipe 320, and the UV curable resin inside the aneurysm is cured when irradiated with ultraviolet light from the light source 200. It also treats an aneurysm by blocking the flow of blood into the aneurysm.
  • the light source 200 may be configured as a separate ultraviolet lamp when miniaturization is possible, but in the present embodiment, the light source 200 and the nozzle 300 may be inserted into a small catheter 100. It is preferable that it is composed of an optical fiber capable of total reflection so that it can be installed in, one end of the light source 200 can protrude to one end of the catheter, the other end of the light source 200 by placing a UV light generating unit 220 It is preferable to configure the UV light generating unit 220 disposed outside to be irradiated to one end of the light source 200 through the optical fiber.
  • the nozzle 300 described above is preferably in communication with the UV resin supply unit 340 through the connection pipe 320, and the UV resin supply unit 340 supplies the UV curable resin. It is desirable to be able to control the feed rate, flow rate of the UV curing resin. Therefore, in the case of the UV resin supply unit 340 may be composed of a precise small pump, etc., it may be composed of a syringe familiar to the doctor treating the aneurysm as shown in FIG.
  • the UV curable resin used herein is preferably a biocompatible UV curable resin suitable for human use, and the UV curable resin of the present embodiment is added with a photoinitiator to polyethylene glycol diacrylate (PEGDA). UV cured resin was used. In addition, it can be used in combination with a radiopaque material to confirm the location of the catheter 100 during the procedure, and nanoparticles clay to control the swelling, mechanical properties of the cured UV curable resin ) May be used by mixing UV curable resin.
  • PEGDA polyethylene glycol diacrylate
  • the connector 320 is a connector having a circular cross section, but the shape of the connector 320 may be formed in various shapes according to the embodiment of the present invention Self-explanatory in the field
  • one end and the other end of the catheter 100 is formed in communication with the optical fiber insertion groove 110 so that the optical fiber is projected, the optical fiber insertion groove 110
  • the light source 200 disposed in the) is slidably disposed in the optical fiber insertion groove 110 so that when the light source 200 is pressed in the direction of the catheter 100, one end of the light source 200 is separated from one end of the catheter 100. It is desirable to allow stretching.
  • the UV curable resin injected into the aneurysm may be located in various forms. Therefore, in order to be able to effectively cure the UV curable resin located in various forms, it is preferable to allow one end of the light source 200 to extend from one end of the catheter 100.
  • the optical fiber insertion groove 110 may be disposed in the catheter 100 so that the light source 200 may be slidably disposed.
  • the light source 200 disposed in the optical fiber insertion groove 110 may be rotatably disposed in the optical fiber insertion groove 110.
  • one end of the light source 200 may be variously processed according to the area of the ultraviolet light to be irradiated, and in some cases, a microlens may be attached.
  • connection pipe 320 of the UV curable resin injector for treating aneurysm according to the present invention is preferably coated with a UV blocking material 321 to block the ultraviolet light emitted from the optical fiber 200, as shown in FIG. .
  • the UV curable resin may be cured in the connector 320 to close the connector 320. Therefore, the outer surface of the connection tube 320 is preferably coated with a UV blocking material 321 to prevent the transmission of ultraviolet rays, UV blocking material 321 according to the embodiment is the catheter 100 in addition to the outer surface of the connection pipe 320. It can be coated on the outer surface of the.
  • a plurality of curable resin injection holes 310 are formed at one end of the nozzle 300 to correspond to various shapes of the aneurysm.
  • the curable resin may be sprayed, and the curable resin injection hole 310 may be formed to have a different diameter as shown in FIGS. 4B and 4C. This may allow for treatment of various types such as abdominal aneurysms and cerebral aneurysms.
  • the UV curable resin injector for treating an aneurysm according to the first embodiment of the present invention is not coupled to the light source 200 and the connection tube 320, and is formed separately, and thus the ejection position of the UV curable resin and Since the direction and the position where the light source is focused can be adjusted during the procedure, the degree of freedom of the procedure can be increased.
  • one end of the catheter 100 includes a balloon ( 400 may be disposed.
  • the UV curable resin that is sprayed and cured to close the aneurysm may be discharged to the mother blood vessel through the wide neck.
  • the balloon 400 is disposed at one side of the catheter 100, and the UV curable resin is cured inside the aneurysm, and then the balloon is inflated to the wide neck to provide a space between the neck and the balloon 400.
  • the cured UV curable resin in the aneurysm can be prevented from being discharged into the mother blood vessel.
  • Catheter 100 is preferably disposed through the balloon 400 as shown in FIG.
  • the liquid injection pipe 420 for supplying and expanding the liquid to the balloon 400 is disposed.
  • one side of the catheter 100 has a plurality of corrugated modules inside the stent 500 forming a mesh shape. It may be disposed through, or may be disposed outside the stent 500.
  • the stent 500 when the neck is wide and not deep, the stent 500 is inserted into the aneurysm, the UV curable resin injection device for treating an aneurysm is inserted through the stent 500, and the neck is formed through the net formed on the stent 500. It is possible to spray UV curable resin.
  • the stent 500 may prevent the cured UV curable resin from being discharged inside the aneurysm when the neck is wide as described above.
  • the stent 500 and the balloon 400 may be used together.
  • FIG 8 is a longitudinal cross-sectional view of the catheter 100 in the UV curable resin injector for treating aneurysm according to the fourth embodiment of the present invention
  • Figure 9 is a UV curable resin for treating aneurysm in accordance with a fourth embodiment of the present invention
  • the UV curable resin injector for treating aneurysms includes a catheter 100, a light source 200, a connector 320, and a coupling member 600. It includes.
  • the coupling member 600 is disposed between the light source 200 and the connection pipe 320 to perform the function of coupling the light source 200 and the connection pipe 320.
  • the coupling member 600 may be coupled to the entire side of the light source 200 and the connection pipe 320, may be able to couple only a portion as shown in FIG.
  • the UV curable resin injector for treating aneurysm according to the fourth embodiment of the present invention unlike the UV curable resin injector for treating aneurysm according to the first embodiment of the present invention, the light source 200 is connected to the connector 320 Since the light source is focused to an unnecessary place during the procedure, there is no possibility that the liquid UV curable resin is not introduced into the body, and it can be provided to the operator because it only needs to be adjusted as a combined body.
  • a reflective surface 230 may be formed at one end of the light source 200.
  • the reflective surface 230 is inclined so that the UV light transmitted through the light source 200 is reflected in the direction perpendicular to the longitudinal direction of the connecting tube 320 and irradiated to the connecting tube 320.
  • 230 may be formed by a reflective coating.
  • the UV curable resin injector for treating aneurysm is arranged to be movable on the outer circumferential surface of the connection pipe 320, the first to block the UV light irradiated to the connection pipe 320 It is preferable to further include a blocking member 322.
  • the reflective surface 230 is formed at one end of the light source 200 as described above, only the region of the connector 320 that is reflected by the reflective surface 230 and irradiated with UV light is opened, and the remaining portion is UV light may be blocked using the first blocking member 322.
  • the UV curable resin is not cured in the region of the connecting tube 320 blocked by the UV light by the first blocking member 322, the UV blocking is blocked because the first blocking member 322 is not disposed. Curing proceeds in the unheated region.
  • the UV curable resin when the UV curable resin is irradiated only to the area immediately before the UV curable resin is sprayed using the first blocking member 322, the UV curable resin in the connection pipe 320 before the spraying. Since it can be cured to some extent, it is possible to completely cure the UV curable resin injected into the aneurysm in a shorter time.
  • the area blocking the UV light and the area not blocked by the first blocking member 322 are appropriate. Setting is required.
  • the first blocking member 322 is preferably disposed to be movable on the outer circumferential surface of the connecting pipe 320.
  • the type of the UV curing resin, the type of the light source 200, the intensity of the light source 200, and the like should be taken into consideration.
  • connection pipe 320 it is preferable to further include a second blocking member 323 on the outer circumferential surface of one end of the connection pipe 320 to block UV light emitted to the connection pipe 320.
  • a plurality of micro protrusions may be formed on the end surface and the outer circumferential surface of one end of the connection pipe 320.
  • Such a chemical treatment method should be taken into account the material of the connector 320 and the UV curing agent, and further, the cross section of one end of the connector 320 to perform the role of the second blocking member 322 described above. And micro projections or chemical treatment on the outer circumferential surface.
  • the shape of the catheter 100 is described in one embodiment for explaining the present invention. It can be formed in various shapes such as 'J' shape, 'S' shape according to the shape of the aneurysm.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention concerne un dispositif d'injection de résine durcissant aux rayons ultraviolets pour le traitement d'un anévrisme, qui comprend : un cathéter ; une source de lumière qui est disposée à l'intérieur du cathéter et transmet une lumière ultraviolette ; et un tube de liaison qui est disposé à l'écart de la source de lumière, à l'intérieur du cathéter, et transmet une résine durcissant aux rayons ultraviolets.
PCT/KR2013/009546 2012-10-24 2013-10-24 Dispositif d'injection de résine durcissant aux rayons ultraviolets pour le traitement d'un anévrisme WO2014065622A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/696,298 US20150250483A1 (en) 2012-10-24 2015-04-24 Uv-curing resin injection device for aneurism treatment

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2012-0118587 2012-10-24
KR20120118587 2012-10-24
KR1020130126838A KR101546153B1 (ko) 2012-10-24 2013-10-23 동맥류 치료용 uv 경화수지 분사장치
KR10-2013-0126838 2013-10-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/696,298 Continuation US20150250483A1 (en) 2012-10-24 2015-04-24 Uv-curing resin injection device for aneurism treatment

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WO2014065622A1 true WO2014065622A1 (fr) 2014-05-01

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PCT/KR2013/009546 WO2014065622A1 (fr) 2012-10-24 2013-10-24 Dispositif d'injection de résine durcissant aux rayons ultraviolets pour le traitement d'un anévrisme

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114073561A (zh) * 2022-01-20 2022-02-22 北京微刀医疗科技有限公司 一种闭合血管的球囊

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6024754A (en) * 1996-01-18 2000-02-15 Target Therapeutics Inc. Aneurysm closure method
US6033401A (en) * 1997-03-12 2000-03-07 Advanced Closure Systems, Inc. Vascular sealing device with microwave antenna
US20020165593A1 (en) * 2001-05-03 2002-11-07 Reid Hayashi Apparatus and method for aiding thrombosis through polymerization
US6958061B2 (en) * 2000-11-24 2005-10-25 Csaba Truckai Microspheres with sacrificial coatings for vaso-occlusive systems
US20080027378A1 (en) * 2001-09-04 2008-01-31 Micro Therapeutics, Inc. Occlusion catheter having compliant balloon for use with complex vasculature

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6024754A (en) * 1996-01-18 2000-02-15 Target Therapeutics Inc. Aneurysm closure method
US6033401A (en) * 1997-03-12 2000-03-07 Advanced Closure Systems, Inc. Vascular sealing device with microwave antenna
US6958061B2 (en) * 2000-11-24 2005-10-25 Csaba Truckai Microspheres with sacrificial coatings for vaso-occlusive systems
US20020165593A1 (en) * 2001-05-03 2002-11-07 Reid Hayashi Apparatus and method for aiding thrombosis through polymerization
US20080027378A1 (en) * 2001-09-04 2008-01-31 Micro Therapeutics, Inc. Occlusion catheter having compliant balloon for use with complex vasculature

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114073561A (zh) * 2022-01-20 2022-02-22 北京微刀医疗科技有限公司 一种闭合血管的球囊

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