WO2013103119A1 - 自動分析装置および自動分析装置における試薬処理方法 - Google Patents
自動分析装置および自動分析装置における試薬処理方法 Download PDFInfo
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- WO2013103119A1 WO2013103119A1 PCT/JP2012/083745 JP2012083745W WO2013103119A1 WO 2013103119 A1 WO2013103119 A1 WO 2013103119A1 JP 2012083745 W JP2012083745 W JP 2012083745W WO 2013103119 A1 WO2013103119 A1 WO 2013103119A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00613—Quality control
- G01N35/00663—Quality control of consumables
- G01N2035/00673—Quality control of consumables of reagents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
Definitions
- the present invention relates to an automatic analyzer for analyzing biological samples such as blood and urine.
- the automatic analyzer is a device that adds a reagent to a biological sample such as blood or urine and reacts to quantitate the items to be examined. Since the reagent causes a specific reaction depending on the target item, when the user measures a plurality of types of test items, the user installs and registers a plurality of types of reagents corresponding thereto.
- the user generally starts analysis after installing and registering in advance a reagent sufficient for the inspection of the day.
- a reagent storage means for replenishment and a reagent bottle transport means are provided, and the reagent information is managed by managing information on the reagents stored in the two reagent storage means.
- Patent Document 1 for automating and improving the efficiency of reagent management such as registration and reagent replacement work.
- Patent Document 2 Also known is a technique (Patent Document 2) that enables a reagent bottle to be replaced without stopping dispensing even during an analysis operation such as an operation.
- the registered reagent is not always immediately usable, and in many cases, it can be used. Preparation process is necessary.
- a reagent containing magnetic particles such as a reagent used for immunoassay needs to be sufficiently agitated and uniform because the magnetic particles are precipitated at the bottom of the reagent container in the case of a new reagent.
- the stirring of the reagent containing the magnetic particles may be several seconds during the analysis, but the stirring time required for new charging is about 30 seconds. For this reason, if a new reagent is introduced during the analysis operation of the automatic analyzer and the new reagent is agitated, the agitation mechanism of the reagent cannot perform the agitation operation during the analysis and the analysis is interrupted. Must.
- reagents used in automatic analyzers need to be calibrated, and this must also be performed in advance.
- the preparatory process for starting the analysis is performed at the inspection facility, for example, preparatory processing is performed before routine measurement.
- This pre-preparation process cannot be started until the analysis operation related to the requested measurement is completed, and the additionally registered reagent cannot be used in the meantime, when there is already another analysis request. was there.
- An object of the present invention is to provide an automatic analyzer capable of executing a preparatory process for a reagent used for measuring a highly urgent test item even during an analysis operation, and a reagent processing method in the automatic analyzer. Is to realize.
- the object of the present invention is achieved by the following configuration.
- the reagent preparation processing priority according to the reagent remaining state of the reagent container arranged in the reagent storage unit is stored in the storage unit, and is stored in the reagent container that is put into the reagent storage unit.
- the reagent preparation processing priority is read for each reagent and stored in the storage unit according to at least the remaining amount of the reagent in the reagent container arranged in the reagent storage unit, and stored in the storage unit.
- the reagent preparation processing by the reagent preparation mechanism has priority over the sample analysis operation.
- the reagent preparation processing mechanism executes the preparation processing of the reagent put in the reagent storage unit.
- an automatic analyzer capable of executing a preparatory process for a reagent used for measuring a highly urgent test item and a reagent processing method in the automatic analyzer.
- FIG. 1 is an overall configuration diagram of an automatic analyzer to which the present invention is applied. It is a schematic block diagram of an example of the analysis module shown in FIG. It is a block diagram of the reagent processing mechanism including the member and apparatus arrange
- FIG. 5 is a functional block diagram of an overall management computer for controlling the operation shown in the flowchart of FIG. 4. It is an operation
- FIG. 1 is an overall configuration diagram of an automatic analyzer to which the present invention is applied.
- the automatic analyzer includes a sample rack loading unit 1-1, an ID reading unit 1-2, a transport line 1-3, a reexamination transport line 1-4, an analysis module 1-7, A sample rack recovery unit 1-5 and an overall management computer 1-8 are provided.
- the sample rack loading unit 1-1 is a portion for loading a plurality of sample racks.
- the calibrator storage unit 1-6 stores a reagent used for calibration, and is a mechanism that can automatically input a calibrator when requested.
- the analysis module 1-7 is disposed along the transport line 1-3 and is detachably connected to the transport line 1-3.
- the analysis module 1-7 includes a computer 1-10 that performs control for necessary processing in the analysis module 1-7.
- the operations of the sample rack loading unit 1-1, the transfer line 1-3, the reexamination transfer line 1-4, and the sample rack collection unit 1-5 are controlled by the computer 1-9.
- the computers 1-9 and 1-10 and the ID reading unit 1-2 are connected to a computer 1-8 for overall management.
- the computer 1-8 is connected to an operation unit 1-12 for inputting necessary information, a display unit 1-11 for displaying analysis results, and an external network 1-13.
- FIG. 2 is a schematic configuration diagram of an analysis module 2-1, which is an example of the analysis module 1-7 shown in FIG.
- an immune analyzer that analyzes immune items will be described as an example of the analysis module 2-1.
- a sample container 2-3 for holding a sample is installed on the transport rack 2-2 of the analysis module 2-1, and the vicinity of the sample dispensing nozzle 2-4 is provided by a rack transport line 2-18.
- the transport rack 2-2 is moved to the sample dispensing position.
- a plurality of reaction vessels 2-6 can be installed on the incubator disk 2-5, and a rotational motion for moving each of the reaction vessels 2-6 installed in the circumferential direction to a predetermined position is possible.
- the sample dispensing tip and reaction container transport mechanism 2-7 can be moved in three directions of the X axis, the Y axis, and the Z axis, and the sample dispensing tip and reaction container holding member 2-8, the reaction container stirring mechanism 2- 9. Move the sample dispensing tip and reaction vessel disposal hole 2-10, the sample dispensing tip mounting position 2-11, the predetermined range of the incubator disk 2-5, Transport.
- the sample dispensing tip and reaction vessel holding member 2-8 are provided with a plurality of unused reaction vessels and sample dispensing tips.
- the sample dispensing tip and reaction vessel transport mechanism 2-7 moves above the sample dispensing tip and reaction vessel holding member 2-8, descends, moves up after holding an unused reaction vessel, and further moves into an incubator. Move to a predetermined position above the disk 2-5, and move down to install the reaction vessel.
- sample dispensing tip and reaction vessel transport mechanism 2-7 moves above the sample dispensing tip and reaction vessel holding member 2-8, descends, holds the unused sample dispensing tip, and then moves up. Then, it moves above the sample dispensing tip mounting position 2-11 and descends to install the sample dispensing tip.
- the sample dispensing nozzle 2-4 can be rotated and moved up and down, and after rotating and moving above the sample dispensing tip mounting position 2-11, the sample dispensing nozzle 2-4 descends to the tip of the sample dispensing nozzle 2-4. Press-fit the sample dispensing tip.
- the sample dispensing nozzle 2-4 equipped with the sample dispensing tip moves above the sample container 2-3 placed on the transport rack 2-2, and then descends and is held in the sample container 2-3. Aspirate a predetermined amount of sample.
- the sample dispensing nozzle 2-4 that sucks the sample moves to the upper side of the incubator disk 2-5 and then descends, and puts the sample into an unused reaction vessel 2-6 held by the incubator disk 2-5. Discharge. When the sample discharge is completed, the sample dispensing nozzle 2-4 moves above the sample dispensing tip and the reaction container discarding hole 2-10, and discards the used sample dispensing tip from the disposal hole.
- a plurality of reagent containers 2-19 are installed on the reagent disk 2-12.
- a reagent disk cover 2-13 is provided above the reagent disk 2-12, and the inside of the reagent disk 2-12 is kept at a predetermined temperature.
- a reagent disk cover opening 2-14 is provided in a part of the reagent disk cover 2-13.
- the reagent dispensing nozzle 2-15 can be rotated and moved up and down.
- the reagent dispensing nozzle 2-15 moves down above the opening 2-14 of the reagent disk cover 2-13 and then descends to place the tip of the reagent dispensing nozzle 2-15 at a predetermined position.
- a predetermined amount of reagent is aspirated by dipping in the reagent in the reagent container.
- the reagent dispensing nozzle 2-15 After the reagent dispensing nozzle 2-15 has moved up, it rotates and moves above a predetermined position of the incubator disk 2-5 to discharge the reagent into the reaction vessel 2-6.
- the reaction vessel 2-6 from which the sample and reagent have been discharged moves to a predetermined position by the rotation of the incubator disk 2-5, and is moved to the reaction vessel stirring mechanism 2-9 by the sample dispensing tip and the reaction vessel transport mechanism 2-7. It is conveyed.
- the reaction vessel stirring mechanism 2-9 stirs and mixes the sample and the reagent in the reaction vessel by applying a rotational motion to the reaction vessel 2-6.
- the stirred reaction container is returned to a predetermined position of the incubator disk 2-5 by the sample dispensing tip and the reaction container transport mechanism 2-7.
- the reaction liquid suction nozzle 2-16 can be rotated and moved up and down, dispenses the sample and the reagent, the stirring is finished, and the reaction vessel 2-6 is moved above the reaction container 2-6 after a predetermined reaction time has passed. , And descends to suck the reaction solution in the reaction vessel 2-6. The reaction liquid sucked by the reaction liquid suction nozzle 2-16 is analyzed by the detection unit 2-17.
- the reaction vessel 2-6 sucked in the reaction solution is moved to a predetermined position by the rotation of the incubator disc 2-5, and the sample is dispensed from the incubator disc 2-6 by the sample dispensing tip and the reaction vessel transport mechanism 2-7.
- the chip and the reaction container are moved above the waste hole 2-10 and discarded from the waste hole.
- the present invention is not limited to the configuration of the analysis module described above.
- the present invention is applicable to mechanisms other than the mechanism of the analysis module as long as it has a reagent disk.
- the reaction container and the sample dispensing tip are not disposable, and may be used repeatedly by washing, or may have a device configuration without an incubator.
- a general biochemical automatic analyzer Such a configuration may be adopted.
- FIG. 3 is a configuration diagram of the reagent processing mechanism 3-10 including members and devices arranged in the vicinity of the reagent disk 2-12 (shown as the reagent disk 3-2 in FIG. 3).
- 3-1 is a reagent agitation mechanism
- 3-2 is a rotary reagent installation mechanism
- 3-3 is a reagent loader.
- Reagent containers 3-5 (2-19) are installed in the reagent installation mechanism 3-2 and the reagent loader 3-3, and each of the reagent containers 3-5 is required to measure one test item.
- a set of liquid reagents is set. One of them is a reagent containing magnetic particles.
- 3-6 is a reagent information reading mechanism and is installed adjacent to the reagent loader 3-3. Reagent information is given to the reagent container 3-5, and it is possible to acquire reagent information on the reagent loader 3-3 by using this mechanism.
- Reference numeral 3-8 denotes a reagent installation / removal button. By pressing the button, the reagent loader 3-3 can be used to install and remove the reagent with respect to the reagent installation mechanism 3-2.
- 3-4 (corresponding to 2-15) is a reagent dispensing mechanism, and 3-7 (corresponding to 1-10) is an operation PC.
- the operation PC 3-7 holds information such as the remaining amount of reagent, expiration date, reagent type, and lot installed in the automatic analyzer.
- FIG. 4 is a flowchart for determining that the reagent preparation process is performed in advance
- FIG. 5 is a functional block diagram of the overall management computer 1-8 for controlling the operation shown in the flowchart of FIG.
- the overall management computer 1-8 shown in FIG. 5 includes a reagent registration / reading unit 10-1, a memory 10-2, a priority determination unit 10-3, a counter 10-4, and a sample dispensing control unit. 10-5 and a reagent preparation processing scheduling unit 10-6.
- Reagent priority is transmitted from the priority setting unit (display unit 1-11, operation unit 1-12) to reagent registration reading unit 10-1. Then, the priority of the transmitted reagent is stored in the memory 10-2.
- the reagent information read by the reagent reading mechanism 3-6 is stored in the memory 10-2 via the reagent registration reading unit 10-1.
- step 4-1 the reagent registration reading unit 10- 1 confirms whether there is a parameter of the analysis item for the reagent from the data stored in the memory 10-2. If there are parameters, go to step 4-2.
- step 4-1 when there is no parameter, the process proceeds to step 4-5, and the reagent registration reading unit 10-1 downloads the parameter via the external network 1-13, and proceeds to step 4-2.
- step 4-2 the priority determination unit 10-3 determines, based on the data stored in the memory 10-2, the priority of the reagent preparation process in the stored data before the new reagent registration for the newly registered reagent. If (high), the process proceeds to step 4-8, where a command signal is sent to the sample dispensing control unit 10-5 to temporarily stop the sample dispensing scheduling process. That is, the sample dispensing control unit 10-5 temporarily stops the operation of the sample dispensing mechanism 2-4.
- step 4-3 determines whether or not the reagent standby time limit (set by the user) has been exceeded. 10-3 confirms the time measured by the counter 10-4. This waiting time is counted from the time when a reagent container containing a new reagent is put into the reagent disk 3-2 from the reagent loader 3-3. If the standby time limit is exceeded in step 4-3, the process proceeds to step 4-8.
- Step 4-8 as described above, after the sample dispensing scheduling process is temporarily stopped, the process proceeds to Step 4-9, and the priority determination unit 10-3 sends a command signal to the reagent preparation process scheduling unit 10-6.
- the reagent preparation processing scheduling unit 10-6 performs reagent preparation processing scheduling for the newly registered reagent to the reagent processing mechanism 3-10, the calibrator storage unit 1-6, and the like, which are reagent preparation processing mechanisms.
- the priority determination unit 10-3 sends a command signal to the sample dispensing control unit 10-5 to restart the sample dispensing scheduling.
- step 4-3 If it is determined in step 4-3 that the standby time limit has not been exceeded, the process proceeds to step 4-4, and the priority determination unit 10-3 confirms the priority of the reagent preparation process stored in the memory 10-2. If the confirmed priority of the confirmed reagent is (medium), the process proceeds to step 4-6, and the priority determination unit 10-3 controls the sample dispensing control unit 10-5 and the reagent preparation processing scheduling unit 10-6. In this manner, it is confirmed whether or not a mechanism used in the reagent preparation process is free, that is, whether or not the reagent preparation process can be newly executed.
- Step 4-6 if the mechanism for performing the reagent preparation process is free, the process proceeds to Step 4-7, and the priority determination unit 10-3 sends a command signal to the reagent preparation process scheduling unit 10-6, and the reagent preparation process To schedule.
- step 4-6 if the mechanism for performing the reagent preparation process is not available, the process returns to step 4-3.
- Step 4-4 if the priority of the reagent is (low), the process returns to Step 4-3.
- FIG. 6 is an operation flowchart in which the reagent preparation scheduling unit 10-6 controls the reagent preparation processing mechanism (1-6, 3-10) to schedule reagent preparation processing.
- step 5-1 scheduling for checking the amount of the installed reagent is performed.
- step 5-2 scheduling for reagent agitation is performed.
- the lot calibration is the same reagent as the reagent whose calibration has already been measured, and when a reagent having the same lot number is newly put into the automatic analyzer, the new reagent has already been It means to take over the measured calibration data and use it.
- step 5-3 when using the lot calibrate, proceed to step 5-4 to check whether the lot calib exists.
- step 5-4 if there is no lot calibrate, the process proceeds to step 5-5, a calibration execution request is made, and the process is terminated.
- step 5-4 if there is a lot caliber, the process is terminated.
- FIG. 7 and 8 are diagrams showing the elapsed time from the reagent registration of the reagent to the completion of the reagent preparation process (initial stirring of magnetic particles) when the priority during analysis is (high). Is an example when the present invention is not applied, and FIG. 8 is an example when the present invention is applied.
- the inspection request has 5 items.
- the operation in which the mechanism interferes between the reagent preparation process and the analysis operation is “magnetic particle reagent aspiration / addition (c)”. If the priority is high, after “inspection 3”, the initial magnetic particle agitation for item B is planned, so that the elapsed time is t2 ⁇ t1. That is, when the priority of the reagent is (high), the reagent preparation process can be completed earlier in the example to which the present invention is applied.
- FIG. 9 is a diagram showing an example of the reagent preparation processing priority setting screen 7-1 displayed on the display unit 1-11.
- the setting screen of the reagent preparation processing priority is focused on only the remaining amount of the reagent, but the priority may be determined by incorporating other factors such as the stability of the reagent when the reagent is stirred.
- 7-2 is a reagent state
- 7-3 is a combo box for selecting a priority
- 7-4 is a cancel button
- 7-5 is an update button.
- the reagent status can be automatically determined by the reagent registration / reading unit 10-1 of the automatic analyzer, and the priority is automatically changed according to the reagent status and stored in the memory 10-2.
- FIG. 10 is a diagram showing an example of the reagent preparation processing priority order correction screen 11-1 displayed on the display unit 1-11.
- an item 11-2 a reagent preparation process priority order change text box 11-3, a cancel button 11-4, and an update button 11-5 are provided.
- On this screen it is possible to check the priority order of preparation processes for each reagent stored in the memory 10-2 and change the priority order.
- FIG. 11 is a diagram showing an example of the reagent preparation processing standby limit time setting screen 8-1 displayed on the display unit 1-11.
- 8-2 is a priority for reagent preparation processing
- 8-3 is a text box for inputting a waiting time limit (for example, 60 minutes for priority (medium), 480 minutes for (interest))
- 8- 4 is a cancel button
- 8-5 is an update button. Based on the conditions set on this screen, the waiting time limit for the reagent preparation process is determined.
- FIG. 12 is a diagram showing an example of the same calibration use condition setting screen 9-1 displayed on the display unit 1-11.
- 9-2 is a selectable same calibration use condition
- 9-3 is a radio button for selecting a condition
- 9-4 is a cancel button
- 9-5 is an update button. Based on the conditions set on this screen 9-1, it is determined whether or not to use the existing calibration result.
- prior preparation processing for the installed reagent is prioritized and stored in the memory according to the state of the reagent installed in the automatic analyzer.
- a user interface capable of registering the priority for the preparatory operation according to the reagent installation state of the test item of the automatic analyzer is provided. Then, in accordance with the set priority, the preparation process for making the reagent actually usable is prioritized over operations related to other measurements.
- the reagent installation state of the inspection item is, for example, a state where the remaining amount of the reagent is 0 and measurement is impossible, a state where the measurement is possible but the remaining amount of reagent is low, and a reagent used for approximately one day remains There are a state in which reagents for one day or more remain, and a state in which parameters for using the reagents are not registered.
- priorities (high), (medium), and (low) are set for the pre-preparation operation for the installed reagent.
- Schedule with priority At the priority (medium) level, the preliminary preparation process is scheduled in the idle time of the mechanism necessary for the preliminary preparation process without reducing the analysis throughput. In the case of the priority (low), the preliminary preparation process is scheduled when the same reagent becomes, for example, three or less in the automatic analyzer.
- an automatic analyzer capable of executing a preparatory process for a reagent used for measuring a highly urgent test item, and a reagent process in the automatic analyzer A method can be realized.
- each of the functional blocks 10-1 to 10-6 is a separate electrical block from the overall management computer 1-8. It can also be configured as an electronic circuit.
- the reagent preparation processing priority may be prioritized by the reagent installation / removal button 3-8.
- the reagent preparation processing priority of the installed reagent is unconditionally “high”.
- the reagent preparation processing priority of the installed reagent can be determined according to the user setting conditions in advance. According to the present embodiment, even in the case of reagent containers containing the same type of reagent, the priority order can be set flexibly according to the analysis situation.
- 1-1 Sample rack loading unit, 1-2 ... ID reading unit, 1-3 ... transport line, 1-4 ... transport line for re-examination, 1-5 ... sample rack Recovery unit, 1-6... Calibrator storage unit, 1-7... Analysis module, 1-8... Computer for overall management, 1-9... Computer for analysis module, 1-10. Computer for analysis module, 1-11... Display unit, 1-12... Operation unit, 1-13... External network, 2-1... Analysis device, 2-2. -3 ... sample container, 2-4 ... sample dispensing nozzle, 2-5 ... incubator disk, 2-6 ... reaction vessel, 2-7 ... sample dispensing tip and reaction vessel Transport mechanism, 2-8... Sample dispensing tip and reaction vessel holding member 2-9 ... Reaction vessel stirring mechanism, 2-10 ...
- Sample dispensing tip and reaction vessel disposal hole 2-11 ... Sample dispensing tip mounting position, 2-12 ... Reagent disc, 2 -13: Reagent disc cover, 2-14 ... Reagent disc cover opening, 2-15 ... Reagent dispensing nozzle, 2-16 ... Reaction liquid suction nozzle, 2-17 ... Detection Unit, 2-18 ... Rack transport line, 2-19 ... Reagent container, 3-1 ... Magnetic particle stirring mechanism, 3-2 ... Reagent installation mechanism, 3-3 ... Reagent loader 3-4 ... Reagent dispensing mechanism, 3-5 ... Reagent container, 3-6 ... Reagent information reading mechanism, 3-7 ... Operation PC, 3-8 ... Reagent installation / Eject button, 7-1 ...
- Reagent preparation processing priority setting screen 7-2 ... Reagent status, 7-3 ... Priority selection combo box, 7-4 ... Cancel button, 7-5 ... Update button, 8-1 ... Reagent preparation processing standby time limit setting screen, 8-2 ... Reagent preparation processing priority 8-3 ... Text box for entering standby limit time, 8-4 ... Cancel button, 8-5 ... Update button, 9-1 ... Calibrate inheritance condition setting screen, 9-2 ..Caribbean inheritance conditions, 9-3... Radio button for condition selection, 9-4... Cancel button, 9-5... Update button, 10-1. ... Memory, 10-3 ... Priority judgment unit, 10-4 ... Counter, 10-5 ... Sample dispensing control unit, 10-6 ... Reagent preparation scheduling unit, 11-1 ... Reagent preparation process priority order correction screen, 11-2 ... Item, 11-3 ... Priority order Change text box, 11-4 ... Cancel button, 11-5 ... Update button
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Abstract
Description
磁性粒子を含む試薬の撹拌は、分析中であれば数秒で良いが、新規投入時に必要な撹拌時間は約30秒である。このため、自動分析装置が分析動作中に、新規試薬を投入し、その新規試薬の撹拌作業を行うとすると、試薬の撹拌機構は、分析中の撹拌動作を行うことができず、分析を中断しなければならない。
また、3-4(2-15に対応する)は試薬分注機構、3-7(1-10に対応する)は操作PCである。操作PC3-7では、自動分析装置に設置されている試薬の残量、有効期限、試薬種類、ロットなどの情報を保有している。
Claims (13)
- 複数の試薬容器が配置された試薬保管部と、
上記試薬容器に収容された試薬を撹拌する試薬撹拌機構を少なくとも有する試薬準備処理機構と、
上記試薬保管部に配置された試薬容器の試薬準備処理優先度を格納する記憶部と、を備えた自動分析装置において、
当該自動分析装置の分析動作中にも前記試薬保管部に新たに配置させる試薬容器を投入可能な試薬ローダと、
上記試薬保管部に配置された試薬容器内の試薬の試薬準備処理優先度を試薬毎に前記記憶部に格納し、上記記憶部に格納された試薬準備処理優先度に基づいて、前記試薬ローダから新たに投入された試薬に対して、上記試薬準備機構による試薬準備処理を試料分析動作に優先して実行するか否かを判断する制御部と、を備え、
上記制御部の判断に従って、上記試薬準備処理機構が上記試薬保管部に投入された試薬の準備処理を実行することを特徴とする自動分析装置。
- 請求項1記載の自動分析装置において、
前記試薬保管部内に配置された試薬容器に収容された試薬の残量に関する情報を取得する手段を備え、
前記試薬準備処理優先度は、試薬容器内の試薬の残量に関する情報に基づいて設定され、残量に関する情報の変動に伴って更新されることを特徴とする自動分析装置。
- 請求項1記載の自動分析装置において、
前記試薬準備処理優先度を試薬毎に設定する入力手段を備えたことを特徴とする自動分析装置。
- 請求項3記載の自動分析装置において、
前記入力手段は前記試薬ローダの近傍に設けられたボタンであって、
前記ボタンの押下方法によって試薬準備処理優先度を設定することを特徴とする自動分析装置。
- 請求項1記載の自動分析装置において、
上記試薬準備処理優先度を手動で変更する変更手段を備えることを特徴とする自動分析装置。
- 請求項1に記載の自動分析装置において、
上記試薬撹拌機構は、分析動作中にも上記試薬容器に収容された試薬を撹拌する動作を行うように制御されることを特徴とする自動分析装置。
- 請求項2に記載の自動分析装置において、
上記試薬準備処理優先度は、試薬容器内の試薬残量が第一の閾値より少ない場合、1日分の使用量に満たない場合、及び試薬を登録するためのパラメータが設定されていない場合は「高」であり、
試薬容器内の試薬残量が第一の閾値以上第二の閾値以下である場合は「中」であり、
試薬容器内の試薬残量が第二の閾値を超える場合は「抵」であることを特徴とする自動分析装置。
- 請求項7に記載の自動分析装置において、
試薬容器が上記試薬保管部に新たに投入された時点からの時間をカウントするカウンタを備え、
上記試薬準備処理優先度が「中」又は「抵」の場合は、上記カウンタによりカウントされた時間が、予め設定された待機限界時間を超えているか否かを上記制御部が判断し、上記カウントされた時間が上記待機限界時間を超えている場合は、上記制御部の指令により、上記試薬準備処理機構が上記試薬保管部に投入された試薬の準備処理を試料分析動作に優先して実行することを特徴とする自動分析装置。
- 請求項1に記載の自動分析装置において、
上記試薬準備処理機構は、試薬のキャリオブレーションを実行するキャリブレーション機構を有することを特徴とする自動分析装置。
- 請求項8に記載の自動分析装置において、
上記試薬準備処理優先度が「中」の場合であって、上記カウンタによりカウントされた時間が、上記待機限界時間を超えておらず、かつ、上記試薬準備処理機構が使用されていないときは、上記試薬保管部に投入された試薬の準備処理を上記試薬準備処理機構が実行することを特徴とする自動分析装置。
- 請求項10に記載の自動分析装置において、
上記待機限界時間を設定する設定手段を備えることを特徴とする自動分析装置。
- 請求項9に記載の自動分析装置において、
上記記憶部には、試薬保管部に配置された試薬容器内の試薬情報が格納され、上記試薬情報読取機構が読み取った試薬容器の試薬と同一種類の検査項目に使用される試薬が既に上記記憶部に格納され、かつ、キャリブレーションが実行済みである場合、記試薬情報読取機構が読み取った試薬容器の試薬は、上記実行済みのキャリブレーション結果が利用されることを特徴とする自動分析装置。
- 請求項7に記載の自動分析装置において、
上記制御部は、試薬を登録するためのパラメータが設定されていない場合は、検査項目のパラメータを外部ネットワークを介してダウンロードすることを特徴とする自動分析装置。
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