WO2013099789A1 - Sterilization method and sterilization device - Google Patents
Sterilization method and sterilization device Download PDFInfo
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- WO2013099789A1 WO2013099789A1 PCT/JP2012/083210 JP2012083210W WO2013099789A1 WO 2013099789 A1 WO2013099789 A1 WO 2013099789A1 JP 2012083210 W JP2012083210 W JP 2012083210W WO 2013099789 A1 WO2013099789 A1 WO 2013099789A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
- A61L2/186—Peroxide solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/23—Containers, e.g. vials, bottles, syringes, mail
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
- B65B55/10—Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases
Definitions
- the present invention relates to a hydrogen peroxide sterilizing solution. More specifically, when aseptically filling fruit juice beverages, coffee beverages, other soft drinks, etc. into polyethylene terephthalate bottles (hereinafter referred to as PET bottles) or paper containers, PET bottles, PET bottle preforms, or paper containers
- PET bottles polyethylene terephthalate bottles
- the present invention relates to a hydrogen peroxide sterilizing liquid used for sterilizing containers such as, a sterilizing method and a sterilizing apparatus using the same.
- the invention according to claim 1 uses a hydrogen peroxide sterilizing solution obtained by dissolving hydrogen peroxide in a solvent having a boiling point of less than 100 ° C.
- a sterilization method including a step of adhering to an object and a step of drying the object to be sterilized with hot air is employed.
- the solvent may be a mixed solution of water and an alcohol having a boiling point of less than 100 ° C.
- the alcohol may be ethyl alcohol, and the mixing volume ratio of water and ethyl alcohol may be 1: 199 to 1: 0.5.
- the boiling point of the solvent for dissolving hydrogen peroxide is less than 100 ° C., that is, the boiling point is lower than that of water, Compared to the solvent, it is easy to vaporize. Therefore, when the hydrogen peroxide sterilization liquid of the present invention is heated and used as a condensation mist, the vaporization of the solvent proceeds at a low temperature and in a short time compared to the conventional hydrogen peroxide sterilization liquid, and the hydrogen peroxide sterilization liquid correspondingly. It is possible to quickly increase the concentration of hydrogen peroxide therein, thereby obtaining a higher sterilization effect and sterilization efficiency than conventional ones. In other words, while setting the hydrogen peroxide concentration in the hydrogen peroxide sterilizing solution to be low, the concentration can be increased during use.
- the hydrogen peroxide concentration in the hydrogen peroxide sterilizing solution can be designed to be low, and the alcohol as a hydrophobic component is added to the sterilizing agent, so that the hydrogen peroxide is added to the resin. It can also be prevented from adsorbing and penetrating and remaining in a container which is an object of sterilization.
- the sterilization method and sterilization apparatus of the present invention since it has a step (means) for drying with hot air, the hydrogen peroxide concentration can be quickly increased, and the above-mentioned effects can be exhibited smoothly. can do.
- the hydrogen peroxide sterilization liquid used in the present embodiment is composed of hydrogen peroxide (A) and a solvent (B) for dissolving the hydrogen peroxide (A), and the solvent (B) is a liquid having a boiling point of less than 100 ° C. It has characteristics. Each will be described below.
- (A) Hydrogen peroxide As the hydrogen peroxide used in this embodiment, a commercially available aqueous hydrogen peroxide solution having a hydrogen peroxide concentration of 30 to 35% by weight can be usually mentioned. A 3% by weight aqueous hydrogen peroxide solution marketed as oxidol can also be used. There are 30 to 35% by weight aqueous hydrogen peroxide solution for industrial use and food additives, and both can be used in this embodiment, but industrial use is stable to prevent decomposition of hydrogen peroxide. Since an agent or the like is added, an aqueous hydrogen peroxide solution for food additives with few additives is preferable.
- the solvent used in this embodiment is not particularly limited as long as it has a boiling point of less than 100 ° C. and can dissolve the hydrogen peroxide.
- a solvent having a boiling point of less than 100 ° C. the solvent can be vaporized more smoothly than a conventional hydrogen peroxide sterilizing solution using water (boiling point is 100 ° C.) as a solvent.
- the concentration of hydrogen peroxide can be improved over time (the concentration of hydrogen peroxide increases as the solvent is evaporated). As a result, the sterilization effect and sterilization efficiency can be improved.
- Such a solvent may be a single substance or a mixture.
- methyl alcohol, ethyl alcohol, isopropyl alcohol, acetone and the like can be suitably used, and among these, ethyl alcohol is particularly preferable. Since ethyl alcohol is recognized as a food additive, it can be used as a sterilization target for food containers, and is easy to obtain and handle and relatively inexpensive.
- the solvent when the solvent is a mixture, it is preferable to use a mixture of the above methyl alcohol, ethyl alcohol, isopropyl alcohol, acetone and the like and water. It is particularly preferred to use a mixture of alcohol and water.
- the mixing volume ratio can be appropriately selected in consideration of the boiling point of the whole solvent.
- the mixing volume ratio is preferably 1: 199 to 1: 0.5. This is because, by various experiments, effective results could be obtained within this range.
- the hydrogen peroxide sterilization liquid described above is used for sterilization of plastic containers represented by PET bottles, sterilization of preforms before molding PET bottles, and further sterilization of paper containers filled with dairy products, etc. It can be used for sterilization of various containers.
- the method includes a step of adhering the hydrogen peroxide sterilization liquid to an object to be sterilized, and a step of drying the object to be sterilized with hot air, and sterilizing the hydrogen peroxide sterilization liquid. It can be suitably used in a sterilization apparatus including means for adhering to an object and means for drying the object to be sterilized with hot air.
- the hydrogen peroxide sterilizing liquid is misted by the mist generator shown in FIG. Uniform adhesion is possible.
- the mist generator includes a hydrogen peroxide sterilizing liquid supply unit 1 that is a two-fluid spray that supplies hydrogen peroxide sterilizing liquid in a drop form, and the hydrogen peroxide sterilizing liquid supply unit 1. And a vaporizing section 2 for heating and atomizing the spray of the supplied hydrogen peroxide sterilizing liquid to a non-decomposition temperature equal to or higher than its boiling point.
- the hydrogen peroxide sterilizing liquid supply unit 1 introduces the hydrogen peroxide sterilizing liquid and compressed air from the hydrogen peroxide sterilizing liquid supply path 1a and the compressed air supply path 1b, respectively, and sprays the hydrogen peroxide sterilizing liquid into the vaporizing unit 9. It is supposed to be.
- the vaporizer 2 is a pipe having a heater 2a sandwiched between inner and outer walls, and heats and vaporizes the spray of the hydrogen peroxide sterilizing solution blown into the pipe.
- This vaporized mixture is a mixture of hydrogen peroxide gas and solvent gas, and is ejected as condensed mist from the discharge nozzle 2b to the outside of the vaporizing section 2.
- this mist is introduced into the PET bottle in the process of attaching the hydrogen peroxide sterilizing solution to the object to be sterilized.
- the step (means) for attaching the hydrogen peroxide sterilizing solution and the drying step (means) are not particularly limited, and conventionally known steps (means) can be used.
- Example 1 A hydrogen peroxide sterilizing solution of Example 1 was produced with hydrogen peroxide: 27.1% by volume, water: 23.1% by volume, and ethanol: 49.8% by volume.
- the solvent of this sterilizing solution is a mixture of water and ethanol, and its boiling point is less than 100 ° C.
- the residual hydrogen peroxide concentration in the bottle was measured by the oxygen electrode method.
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Abstract
A sterilization method using a liquid sterilizer comprising hydrogen peroxide, said liquid sterilizer being prepared by dissolving hydrogen peroxide in a solvent, wherein a liquid having a boiling point lower than 100oC is used as the solvent. By sterilizing a molded plastic container typified by a polyethylene terephthalate bottle or a paper container by attaching a mist of the aforesaid liquid sterilizer comprising hydrogen peroxide thereto, sterilization effect and sterilization efficiency can be increased and the amount of the sterilizer remaining in the container can be reduced.
Description
本発明は、過酸化水素殺菌液に関する。より具体的には、果汁飲料、コーヒー飲料、その他の清涼飲料水等をポリエチレンテレフタレート製ボトル（以下ＰＥＴボトルという）や紙容器に無菌充填する際、ＰＥＴボトル、ＰＥＴボトル用プリフォーム、又は紙容器等の容器を殺菌するために用いられる過酸化水素殺菌液、およびこれを用いた殺菌方法、殺菌装置に関する。
The present invention relates to a hydrogen peroxide sterilizing solution. More specifically, when aseptically filling fruit juice beverages, coffee beverages, other soft drinks, etc. into polyethylene terephthalate bottles (hereinafter referred to as PET bottles) or paper containers, PET bottles, PET bottle preforms, or paper containers The present invention relates to a hydrogen peroxide sterilizing liquid used for sterilizing containers such as, a sterilizing method and a sterilizing apparatus using the same.
従来、果汁飲料やコーヒー飲料等を容器内に無菌充填する場合、内容物を充填する前段階において容器を予め殺菌する必要がある。ここで、用いられる容器がＰＥＴボトルに代表されるプラスチック成形容器の場合には、「成形したＰＥＴボトルを無菌充填機に供給し、無菌充填機内で過酸化水素殺菌液をＰＥＴボトルにスプレーし、その後乾燥することによりＰＥＴボトルを殺菌し、内容物を無菌充填する方法。」や、「ＰＥＴボトル成形時にボトルの内面に少量の過酸化水素殺菌液を滴下し、口部を密封しつつ、過酸化水素殺菌液を気化せしめ、その蒸気によってボトルの内面を殺菌し、この殺菌ボトルを無菌充填機に供給して、無菌充填機内でボトルの外面を殺菌した後、口部を開封して内容物を無菌充填する方法。」など、過酸化水素殺菌液が用いられる場合が多い（たとえば、特許文献１～４）。
Conventionally, when aseptically filling fruit juice drinks, coffee drinks, or the like into a container, it is necessary to sterilize the container in advance before filling the contents. Here, in the case where the container used is a plastic molded container represented by a PET bottle, “supply the molded PET bottle to an aseptic filling machine, and spray the hydrogen peroxide sterilizing liquid on the PET bottle in the aseptic filling machine, After that, the PET bottle is sterilized by drying and the contents are aseptically filled. ”Or“ A small amount of hydrogen peroxide sterilizing solution is dropped on the inner surface of the bottle when molding the PET bottle, The hydrogen oxide sterilization liquid is vaporized, the inner surface of the bottle is sterilized by the vapor, the sterilized bottle is supplied to the aseptic filling machine, the outer surface of the bottle is sterilized in the aseptic filling machine, the mouth is opened, and the contents In many cases, a hydrogen peroxide sterilizing solution is used (for example, Patent Documents 1 to 4).
また、ＰＥＴボトルは射出成形によりプリフォームを製造しそのプリフォームをブロー成形機で延伸ブローして作製されるものであることを利用し、ＰＥＴボトルとなる前のプリフォームの段階で殺菌処理を行うことも提案されており、この場合においても、上記の方法と同様、過酸化水素殺菌液が用いられている（たとえば、特許文献５）。
Also, PET bottles are manufactured by injection molding, and the preforms are produced by stretching and blowing with a blow molding machine, and sterilized at the stage of preforms before becoming PET bottles. In this case, a hydrogen peroxide sterilizing solution is used (for example, Patent Document 5).
しかしながら、ＰＥＴボトルとなった状態で殺菌するか、その前段階であるプリフォームの段階で殺菌するかに関わらず、殺菌効果および殺菌効率の向上を図るためには過酸化水素殺菌液中の過酸化水素濃度を高くすることが必要であるが、単に過酸化水素の量を増やすのは、コストパフォーマンスが低下し、また高濃度の過酸化水素殺菌液はそのハンドリングも悪くなる。さらに、過酸化水素の濃度を高くすると、過酸化水素が容器やプリフォーム内に残留してしまうといった問題も生じやすくなってしまう。
However, in order to improve the sterilization effect and the sterilization efficiency regardless of whether the PET bottle is sterilized or in the preform stage which is the previous stage, the excess in the hydrogen peroxide sterilization solution is required. Although it is necessary to increase the hydrogen oxide concentration, simply increasing the amount of hydrogen peroxide reduces the cost performance, and the high concentration hydrogen peroxide sterilizing solution also deteriorates the handling. Furthermore, when the concentration of hydrogen peroxide is increased, a problem that hydrogen peroxide remains in the container or the preform is likely to occur.
本発明はこのような状況においてなされたものであり、ＰＥＴボトルに代表されるプラスチック成形容器や紙容器などを殺菌するのに好適に用いることができ、殺菌効果および殺菌効率が高く、かつ容器内への残留することもない過酸化水素殺菌液、およびこれを用いた殺菌方法と殺菌装置を提供することを主たる課題とする。
The present invention has been made in such a situation, and can be suitably used for sterilizing plastic molded containers and paper containers typified by PET bottles. The main object is to provide a hydrogen peroxide sterilizing solution that does not remain in the water, and a sterilization method and sterilizer using the same.
上記課題を解決するため請求項１に係る発明は、過酸化水素を沸点が１００℃未満の液体である溶媒に溶解してなる過酸化水素殺菌液を用い、当該過酸化水素殺菌液を殺菌対象物に付着せしめる工程と、殺菌対象物をホットエアーで乾燥させる工程と、を含む殺菌方法を採用する。
In order to solve the above-mentioned problem, the invention according to claim 1 uses a hydrogen peroxide sterilizing solution obtained by dissolving hydrogen peroxide in a solvent having a boiling point of less than 100 ° C. A sterilization method including a step of adhering to an object and a step of drying the object to be sterilized with hot air is employed.
また、上記の発明にあっては、前記溶媒が、水と、沸点が１００℃未満のアルコールとの混合液であってもよい。
In the above invention, the solvent may be a mixed solution of water and an alcohol having a boiling point of less than 100 ° C.
さらに、上記の発明にあっては、前記アルコールがエチルアルコールであり、水とエチルアルコールとの混合体積比が１：１９９～１：０．５であってもよい。
Furthermore, in the above invention, the alcohol may be ethyl alcohol, and the mixing volume ratio of water and ethyl alcohol may be 1: 199 to 1: 0.5.
本発明によれば、過酸化水素を溶解するための溶媒の沸点が１００℃未満、つまり水よりも低い沸点を有しているため、水を溶媒として用いている従来の過酸化水素殺菌液と比べて溶媒が気化しやすい。したがって、本発明の過酸化水素殺菌液を加熱し凝結ミストとして用いた場合、従来の過酸化水素殺菌液と比べて、低温かつ短時間で溶媒の気化が進み、その分だけ過酸化水素殺菌液中の過酸化水素濃度を速やかに高くすることができ、これにより従来と比べて高い殺菌効果および殺菌効率を得ることができる。換言すれば、過酸化水素殺菌液中の過酸化水素濃度を低く設定しつつ、使用時においてはこれを高濃度化することができる。
According to the present invention, since the boiling point of the solvent for dissolving hydrogen peroxide is less than 100 ° C., that is, the boiling point is lower than that of water, Compared to the solvent, it is easy to vaporize. Therefore, when the hydrogen peroxide sterilization liquid of the present invention is heated and used as a condensation mist, the vaporization of the solvent proceeds at a low temperature and in a short time compared to the conventional hydrogen peroxide sterilization liquid, and the hydrogen peroxide sterilization liquid correspondingly. It is possible to quickly increase the concentration of hydrogen peroxide therein, thereby obtaining a higher sterilization effect and sterilization efficiency than conventional ones. In other words, while setting the hydrogen peroxide concentration in the hydrogen peroxide sterilizing solution to be low, the concentration can be increased during use.
また、本発明によれば、過酸化水素殺菌液中の過酸化水素濃度を低く設計することができる上、疎水性成分であるアルコールが殺菌剤に添加されることにより、過酸化水素が樹脂に吸着・浸透し、殺菌対象物である容器に残留することも防止することができる。
Further, according to the present invention, the hydrogen peroxide concentration in the hydrogen peroxide sterilizing solution can be designed to be low, and the alcohol as a hydrophobic component is added to the sterilizing agent, so that the hydrogen peroxide is added to the resin. It can also be prevented from adsorbing and penetrating and remaining in a container which is an object of sterilization.
さらに、本発明の殺菌方法および殺菌装置によれば、ホットエアーで乾燥する工程（手段）を有しているため、過酸化水素濃度を速やかに上昇せしめることができ、上述の効果をスムーズに発揮することができる。
Furthermore, according to the sterilization method and sterilization apparatus of the present invention, since it has a step (means) for drying with hot air, the hydrogen peroxide concentration can be quickly increased, and the above-mentioned effects can be exhibited smoothly. can do.
本実施形態で用いる過酸化水素殺菌液は、過酸化水素（Ａ）と、これを溶解せしめるための溶媒（Ｂ）とからなり、当該溶媒（Ｂ）が沸点１００℃未満の液体であることに特徴を有している。以下、それぞれについて説明する。
The hydrogen peroxide sterilization liquid used in the present embodiment is composed of hydrogen peroxide (A) and a solvent (B) for dissolving the hydrogen peroxide (A), and the solvent (B) is a liquid having a boiling point of less than 100 ° C. It has characteristics. Each will be described below.
（Ａ）過酸化水素
本実施形態に用いられる過酸化水素としては、通常、市販の過酸化水素濃度が３０～３５重量％の過酸化水素水溶液を挙げることができる。また、オキシドールとして市販されている３重量％の過酸化水素水溶液も使用できる。３０～３５重量％の過酸化水素水溶液としては、工業用と食品添加物用があり、本実施形態においてはいずれも使用可能であるが、工業用は過酸化水素の分解を防止するために安定剤等が添加されているので、添加物の少ない食品添加物用の過酸化水素水溶液が好適である。 (A) Hydrogen peroxide As the hydrogen peroxide used in this embodiment, a commercially available aqueous hydrogen peroxide solution having a hydrogen peroxide concentration of 30 to 35% by weight can be usually mentioned. A 3% by weight aqueous hydrogen peroxide solution marketed as oxidol can also be used. There are 30 to 35% by weight aqueous hydrogen peroxide solution for industrial use and food additives, and both can be used in this embodiment, but industrial use is stable to prevent decomposition of hydrogen peroxide. Since an agent or the like is added, an aqueous hydrogen peroxide solution for food additives with few additives is preferable.
本実施形態に用いられる過酸化水素としては、通常、市販の過酸化水素濃度が３０～３５重量％の過酸化水素水溶液を挙げることができる。また、オキシドールとして市販されている３重量％の過酸化水素水溶液も使用できる。３０～３５重量％の過酸化水素水溶液としては、工業用と食品添加物用があり、本実施形態においてはいずれも使用可能であるが、工業用は過酸化水素の分解を防止するために安定剤等が添加されているので、添加物の少ない食品添加物用の過酸化水素水溶液が好適である。 (A) Hydrogen peroxide As the hydrogen peroxide used in this embodiment, a commercially available aqueous hydrogen peroxide solution having a hydrogen peroxide concentration of 30 to 35% by weight can be usually mentioned. A 3% by weight aqueous hydrogen peroxide solution marketed as oxidol can also be used. There are 30 to 35% by weight aqueous hydrogen peroxide solution for industrial use and food additives, and both can be used in this embodiment, but industrial use is stable to prevent decomposition of hydrogen peroxide. Since an agent or the like is added, an aqueous hydrogen peroxide solution for food additives with few additives is preferable.
（Ｂ）溶媒
本実施形態に用いられる溶媒は、その沸点が１００℃未満の液体であり、かつ前記過酸化水素を溶解可能であれば特に限定されることはない。沸点が１００℃未満の溶媒を用いることにより、水（沸点は１００℃）を溶媒として用いている従来の過酸化水素殺菌液と比べて溶媒の気化をスムーズに行うことができるので、低温かつ短時間で過酸化水素の濃度を向上させることができる（溶媒が気化した分だけ、過酸化水素濃度は向上する）。その結果、殺菌効果および殺菌効率を向上することができる。 (B) Solvent The solvent used in this embodiment is not particularly limited as long as it has a boiling point of less than 100 ° C. and can dissolve the hydrogen peroxide. By using a solvent having a boiling point of less than 100 ° C., the solvent can be vaporized more smoothly than a conventional hydrogen peroxide sterilizing solution using water (boiling point is 100 ° C.) as a solvent. The concentration of hydrogen peroxide can be improved over time (the concentration of hydrogen peroxide increases as the solvent is evaporated). As a result, the sterilization effect and sterilization efficiency can be improved.
本実施形態に用いられる溶媒は、その沸点が１００℃未満の液体であり、かつ前記過酸化水素を溶解可能であれば特に限定されることはない。沸点が１００℃未満の溶媒を用いることにより、水（沸点は１００℃）を溶媒として用いている従来の過酸化水素殺菌液と比べて溶媒の気化をスムーズに行うことができるので、低温かつ短時間で過酸化水素の濃度を向上させることができる（溶媒が気化した分だけ、過酸化水素濃度は向上する）。その結果、殺菌効果および殺菌効率を向上することができる。 (B) Solvent The solvent used in this embodiment is not particularly limited as long as it has a boiling point of less than 100 ° C. and can dissolve the hydrogen peroxide. By using a solvent having a boiling point of less than 100 ° C., the solvent can be vaporized more smoothly than a conventional hydrogen peroxide sterilizing solution using water (boiling point is 100 ° C.) as a solvent. The concentration of hydrogen peroxide can be improved over time (the concentration of hydrogen peroxide increases as the solvent is evaporated). As a result, the sterilization effect and sterilization efficiency can be improved.
このような溶媒は、単一物であっても混合物であってもよい。
Such a solvent may be a single substance or a mixture.
溶媒を単一物とする場合には、たとえば、メチルアルコール、エチルアルコール、イソプロピルアルコール、アセトンなどを好適に用いることができ、この中でもエチルアルコールが特に好ましい。エチルアルコールは食品添加物として認められているため、食品用の容器を殺菌対象物とすることができる上、入手、取り扱いともに容易であり、比較的安価だからである。
When a single solvent is used, for example, methyl alcohol, ethyl alcohol, isopropyl alcohol, acetone and the like can be suitably used, and among these, ethyl alcohol is particularly preferable. Since ethyl alcohol is recognized as a food additive, it can be used as a sterilization target for food containers, and is easy to obtain and handle and relatively inexpensive.
一方で、溶媒を混合物とする場合には、上記のメチルアルコール、エチルアルコール、イソプロピルアルコール、アセトンなどと水とを混合した混合物を用いることが好ましく、中でも単一物の場合と同様の理由によりエチルアルコールと水との混合物を用いることが特に好ましい。
On the other hand, when the solvent is a mixture, it is preferable to use a mixture of the above methyl alcohol, ethyl alcohol, isopropyl alcohol, acetone and the like and water. It is particularly preferred to use a mixture of alcohol and water.
また、溶媒を混合物とする場合、それぞれの混合体積比は溶媒全体の沸点などを考慮して適宜選択することができるが、たとえば、溶媒としてエチルアルコールと水との混合物を用いる場合には、その混合体積比は１：１９９～１：０．５とすることが好ましい。種々の実験により、この範囲であれば有効な結果を得ることができたからである。
In addition, when the solvent is a mixture, the mixing volume ratio can be appropriately selected in consideration of the boiling point of the whole solvent. For example, when a mixture of ethyl alcohol and water is used as the solvent, The mixing volume ratio is preferably 1: 199 to 1: 0.5. This is because, by various experiments, effective results could be obtained within this range.
上記で説明した過酸化水素殺菌液は、ＰＥＴボトルに代表されるプラスチック容器の殺菌、ＰＥＴボトルを成型する前段階のプリフォームの殺菌、さらには、乳製品などが充填される紙容器の殺菌など、各種容器の殺菌に用いることができる。
The hydrogen peroxide sterilization liquid described above is used for sterilization of plastic containers represented by PET bottles, sterilization of preforms before molding PET bottles, and further sterilization of paper containers filled with dairy products, etc. It can be used for sterilization of various containers.
より具体的には、上記過酸化水素殺菌液を殺菌対象物に付着せしめる工程と、殺菌対象物をホットエアーで乾燥させる工程と、を含むこと殺菌方法、および、当該過酸化水素殺菌液を殺菌対象物に付着せしめる手段と、殺菌対象物をホットエアーで乾燥させる手段と、を含むこと殺菌装置において好適に用いることができる。
More specifically, the method includes a step of adhering the hydrogen peroxide sterilization liquid to an object to be sterilized, and a step of drying the object to be sterilized with hot air, and sterilizing the hydrogen peroxide sterilization liquid. It can be suitably used in a sterilization apparatus including means for adhering to an object and means for drying the object to be sterilized with hot air.
上記過酸化水素殺菌液を殺菌対象物に付着せしめるには、過酸化水素殺菌液を図２に示すミスト生成器によりミスト化し、このミストを殺菌対象物に供給することにより殺菌対象物の表面に均一に付着させることができる。
In order to attach the hydrogen peroxide sterilizing liquid to the object to be sterilized, the hydrogen peroxide sterilizing liquid is misted by the mist generator shown in FIG. Uniform adhesion is possible.
図２に示すように、このミスト生成器は、過酸化水素殺菌液を滴状にして供給する二流体スプレーである過酸化水素殺菌液供給部１と、この過酸化水素殺菌液供給部１から供給された過酸化水素殺菌液の噴霧をその沸点以上の非分解温度以下に加熱して気化させる気化部２とを備える。過酸化水素殺菌液供給部１は、過酸化水素殺菌液供給路１ａ及び圧縮空気供給路１ｂからそれぞれ過酸化水素殺菌液と圧縮空気を導入して過酸化水素殺菌液を気化部９内に噴霧するようになっている。気化部２は内外壁間にヒータ２ａを挟み込んだパイプであり、このパイプ内に吹き込まれた過酸化水素殺菌液の噴霧を加熱し気化させる。この気化したものは過酸化水素のガスと溶媒のガスとの混合気であり、吐出ノズル２ｂから気化部２外に凝結ミストとなって噴出する。
As shown in FIG. 2, the mist generator includes a hydrogen peroxide sterilizing liquid supply unit 1 that is a two-fluid spray that supplies hydrogen peroxide sterilizing liquid in a drop form, and the hydrogen peroxide sterilizing liquid supply unit 1. And a vaporizing section 2 for heating and atomizing the spray of the supplied hydrogen peroxide sterilizing liquid to a non-decomposition temperature equal to or higher than its boiling point. The hydrogen peroxide sterilizing liquid supply unit 1 introduces the hydrogen peroxide sterilizing liquid and compressed air from the hydrogen peroxide sterilizing liquid supply path 1a and the compressed air supply path 1b, respectively, and sprays the hydrogen peroxide sterilizing liquid into the vaporizing unit 9. It is supposed to be. The vaporizer 2 is a pipe having a heater 2a sandwiched between inner and outer walls, and heats and vaporizes the spray of the hydrogen peroxide sterilizing solution blown into the pipe. This vaporized mixture is a mixture of hydrogen peroxide gas and solvent gas, and is ejected as condensed mist from the discharge nozzle 2b to the outside of the vaporizing section 2.
このミストが、図１に示すように、過酸化水素殺菌液を殺菌対象物に付着せしめる工程においてＰＥＴボトル内に導入される。
As shown in FIG. 1, this mist is introduced into the PET bottle in the process of attaching the hydrogen peroxide sterilizing solution to the object to be sterilized.
なお、吐出ノズル２ｂから気化部２外に出る凝結ミストに対し、吐出ノズル２ｂの先端でホットエアーと混合させてガス化したうえで、ＰＥＴボトル内に導入するようにしてもよい。このガスはＰＥＴボトル内に入ってボトル内壁に付着する際に凝結し、殺菌力を発揮する。
In addition, after condensing mist which comes out of the vaporization part 2 from the discharge nozzle 2b, it is made to mix with hot air at the front-end | tip of the discharge nozzle 2b, and you may make it introduce | transduce into a PET bottle. This gas is condensed when entering the PET bottle and adhering to the inner wall of the bottle, and exhibits sterilizing power.
なお、過酸化水素殺菌液を付着せしめる工程（手段）および乾燥させる工程（手段）については、特に限定されることはなく、従来公知の工程（手段）を用いることができる。
The step (means) for attaching the hydrogen peroxide sterilizing solution and the drying step (means) are not particularly limited, and conventionally known steps (means) can be used.
（実施例１）
過酸化水素：２７．１体積％、水：２３．１体積％、エタノール：４９．８体積％の実施例１の過酸化水素殺菌液を製造した。この殺菌液の溶媒は水とエタノールの混合物であり、その沸点は１００℃未満である。 Example 1
A hydrogen peroxide sterilizing solution of Example 1 was produced with hydrogen peroxide: 27.1% by volume, water: 23.1% by volume, and ethanol: 49.8% by volume. The solvent of this sterilizing solution is a mixture of water and ethanol, and its boiling point is less than 100 ° C.
過酸化水素：２７．１体積％、水：２３．１体積％、エタノール：４９．８体積％の実施例１の過酸化水素殺菌液を製造した。この殺菌液の溶媒は水とエタノールの混合物であり、その沸点は１００℃未満である。 Example 1
A hydrogen peroxide sterilizing solution of Example 1 was produced with hydrogen peroxide: 27.1% by volume, water: 23.1% by volume, and ethanol: 49.8% by volume. The solvent of this sterilizing solution is a mixture of water and ethanol, and its boiling point is less than 100 ° C.
（比較例１）
過酸化水素：２７．１体積％、水７２．９体積％の比較例１の過酸化水素殺菌液を製造した。この殺菌液の溶媒は水のみであるため、その沸点は１００℃となる。 (Comparative Example 1)
Hydrogen peroxide: A hydrogen peroxide sterilizing solution of Comparative Example 1 having 27.1 vol% and water 72.9 vol% was produced. Since the solvent of this sterilizing liquid is only water, its boiling point is 100 ° C.
過酸化水素：２７．１体積％、水７２．９体積％の比較例１の過酸化水素殺菌液を製造した。この殺菌液の溶媒は水のみであるため、その沸点は１００℃となる。 (Comparative Example 1)
Hydrogen peroxide: A hydrogen peroxide sterilizing solution of Comparative Example 1 having 27.1 vol% and water 72.9 vol% was produced. Since the solvent of this sterilizing liquid is only water, its boiling point is 100 ° C.
（比較試験）
容量５００ｍｌのＰＥＴボトルを用いて、Ｂ．ｓｕｂｔｉｌｉｓ芽胞に対する殺菌効果と残留過酸化水素濃度について試験を行った。 (Comparative test)
Using a 500 ml PET bottle, The bactericidal effect on subtilis spores and residual hydrogen peroxide concentration were tested.
容量５００ｍｌのＰＥＴボトルを用いて、Ｂ．ｓｕｂｔｉｌｉｓ芽胞に対する殺菌効果と残留過酸化水素濃度について試験を行った。 (Comparative test)
Using a 500 ml PET bottle, The bactericidal effect on subtilis spores and residual hydrogen peroxide concentration were tested.
具体的には、図１及び図２に示す装置を用いて、菌付けした各ＰＥＴボトルに１１５℃の実施例１の過酸化水素殺菌液のガスおよび比較例１の過酸化水素殺菌液のガスを各々３秒間導入し、１．３秒後に１００℃のホットエアーで４．６秒間エアーリンス処理した。その後、ボトルにＳＣＤブイヨン培地を分注し、滅菌済みキャップで密栓し３５℃で７日間培養した。培養したボトルの陽性・陰性本数より生存菌数をＭＰＮより計算し、滅菌効果を下記式で算出した。
Specifically, using the apparatus shown in FIG. 1 and FIG. 2, the hydrogen peroxide sterilization gas of Example 1 and the hydrogen peroxide sterilization gas of Comparative Example 1 at 115 ° C. are applied to each sterilized PET bottle. Each was introduced for 3 seconds, and after 1.3 seconds, it was air rinsed with hot air at 100 ° C. for 4.6 seconds. Thereafter, SCD broth medium was dispensed into the bottle, sealed with a sterilized cap, and cultured at 35 ° C. for 7 days. The number of viable bacteria was calculated from the positive and negative numbers of the cultured bottles by MPN, and the sterilization effect was calculated by the following formula.
滅菌効果（Ｌｏｇ Ｒｅｄｕｃｔｉｏｎ）＝Ｌｏｇ（付着菌数／ＭＰＮ）
Sterilization effect (Log Reduction) = Log (number of adherent bacteria / MPN)
また、ボトル内の残留過酸化水素濃度は、酸素電極法で測定した。
Also, the residual hydrogen peroxide concentration in the bottle was measured by the oxygen electrode method.
実施例１および比較例１それぞれの滅菌効果と残留過酸化水素濃度を以下の表１に示す。
The sterilization effect and residual hydrogen peroxide concentration of Example 1 and Comparative Example 1 are shown in Table 1 below.
（結果）
表１より、過酸化水素濃度が２７．１体積％と同一であるにも関わらず、溶媒の沸点が１００℃未満である、つまり溶媒が水とエタノールの混合物である実施例１の殺菌液の法が比較例１と比べて滅菌効果が１．６ＬＲＶ以上向上した。加えて、残留過酸化水素濃度が２０％減少した。 (result)
According to Table 1, the bactericidal solution of Example 1 in which the boiling point of the solvent is less than 100 ° C., that is, the solvent is a mixture of water and ethanol, although the hydrogen peroxide concentration is the same as 27.1% by volume. Compared with Comparative Example 1, the sterilization effect was improved by 1.6 LRV or more. In addition, the residual hydrogen peroxide concentration was reduced by 20%.
表１より、過酸化水素濃度が２７．１体積％と同一であるにも関わらず、溶媒の沸点が１００℃未満である、つまり溶媒が水とエタノールの混合物である実施例１の殺菌液の法が比較例１と比べて滅菌効果が１．６ＬＲＶ以上向上した。加えて、残留過酸化水素濃度が２０％減少した。 (result)
According to Table 1, the bactericidal solution of Example 1 in which the boiling point of the solvent is less than 100 ° C., that is, the solvent is a mixture of water and ethanol, although the hydrogen peroxide concentration is the same as 27.1% by volume. Compared with Comparative Example 1, the sterilization effect was improved by 1.6 LRV or more. In addition, the residual hydrogen peroxide concentration was reduced by 20%.
１…過酸化水素殺菌液供給部
１ａ…過酸化水素殺菌液供給路
１ｂ…圧縮空気供給路
２…気化部
２ａ…ヒータ
２ｂ…吐出ノズル DESCRIPTION OF SYMBOLS 1 ... Hydrogen peroxide disinfectionliquid supply part 1a ... Hydrogen peroxide disinfection liquid supply path 1b ... Compressed air supply path 2 ... Vaporization part 2a ... Heater 2b ... Discharge nozzle
１ａ…過酸化水素殺菌液供給路
１ｂ…圧縮空気供給路
２…気化部
２ａ…ヒータ
２ｂ…吐出ノズル DESCRIPTION OF SYMBOLS 1 ... Hydrogen peroxide disinfection
Claims (4)
- 過酸化水素を沸点が１００℃未満の液体である溶媒に溶解してなる過酸化水素殺菌液を用い、
当該過酸化水素殺菌液を殺菌対象物に付着せしめる工程と、
殺菌対象物をホットエアーで乾燥させる工程と、
を含むことを特徴とする殺菌方法。 Using a hydrogen peroxide sterilizing solution obtained by dissolving hydrogen peroxide in a solvent having a boiling point of less than 100 ° C.,
Attaching the hydrogen peroxide sterilization liquid to the object to be sterilized;
A step of drying the object to be sterilized with hot air;
A sterilization method comprising: - 請求項１に記載の殺菌方法において、前記溶媒として、水と、沸点が１００℃未満のアルコールとの混合液を用いることを特徴とする殺菌方法。 The sterilization method according to claim 1, wherein a mixed liquid of water and an alcohol having a boiling point of less than 100 ° C is used as the solvent.
- 請求項２に記載の殺菌方法において、前記アルコールをエチルアルコールとし、前記混合液における水とエチルアルコールとの混合体積比を１：１９９～１：０．５としたことを特徴とする殺菌方法。 3. The sterilization method according to claim 2, wherein the alcohol is ethyl alcohol, and the mixing volume ratio of water and ethyl alcohol in the mixed solution is 1: 199 to 1: 0.5.
- 過酸化水素を沸点が１００℃未満の液体である溶媒に溶解してなる過酸化水素殺菌液を殺菌対象物に付着せしめる手段と、
殺菌対象物をホットエアーで乾燥させる手段と、
を含むことを特徴とする殺菌装置。 Means for adhering a hydrogen peroxide sterilizing solution obtained by dissolving hydrogen peroxide in a solvent having a boiling point of less than 100 ° C. to an object to be sterilized;
Means for drying the object to be sterilized with hot air;
A sterilizer comprising:
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| WO2017221991A1 (en) | 2016-06-24 | 2017-12-28 | 大日本印刷株式会社 | Method and device for sterilizing preform |
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