WO2012148140A3 - Imidazole-based alkaloid derivatives which have angiogenesis inhibition and antioxidant effects and production method thereof - Google Patents

Imidazole-based alkaloid derivatives which have angiogenesis inhibition and antioxidant effects and production method thereof Download PDF

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Publication number
WO2012148140A3
WO2012148140A3 PCT/KR2012/003103 KR2012003103W WO2012148140A3 WO 2012148140 A3 WO2012148140 A3 WO 2012148140A3 KR 2012003103 W KR2012003103 W KR 2012003103W WO 2012148140 A3 WO2012148140 A3 WO 2012148140A3
Authority
WO
WIPO (PCT)
Prior art keywords
imidazole
antioxidant effects
production method
angiogenesis inhibition
alkaloid derivatives
Prior art date
Application number
PCT/KR2012/003103
Other languages
French (fr)
Korean (ko)
Other versions
WO2012148140A2 (en
Inventor
송호영
김성진
박수호
이향숙
박태교
우성호
김용주
김태윤
김병학
Original Assignee
주식회사 레고켐 바이오사이언스
주식회사 바이오씨에스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 레고켐 바이오사이언스, 주식회사 바이오씨에스 filed Critical 주식회사 레고켐 바이오사이언스
Publication of WO2012148140A2 publication Critical patent/WO2012148140A2/en
Publication of WO2012148140A3 publication Critical patent/WO2012148140A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention relates to imidazole-based alkaloid derivatives represented by formula (1) in the description, pharmaceutically acceptable salts, hydrates, solvates, isomers, prodrugs and a preparation method, thereof, and a pharmaceutical composition containing same which has angiogenesis inhibition and antioxidant effects. In the formula, L, M, m, X, Y, R1 and R2 are as defined in the description.
PCT/KR2012/003103 2011-04-29 2012-04-23 Imidazole-based alkaloid derivatives which have angiogenesis inhibition and antioxidant effects and production method thereof WO2012148140A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0041031 2011-04-29
KR1020110041031A KR20120122705A (en) 2011-04-29 2011-04-29 Imidazole-based Alkaloid Derivatives for Inhibition of Angiogenesis and anti-oxidant activity, and Methods for Preparing them

Publications (2)

Publication Number Publication Date
WO2012148140A2 WO2012148140A2 (en) 2012-11-01
WO2012148140A3 true WO2012148140A3 (en) 2013-01-03

Family

ID=47072878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/003103 WO2012148140A2 (en) 2011-04-29 2012-04-23 Imidazole-based alkaloid derivatives which have angiogenesis inhibition and antioxidant effects and production method thereof

Country Status (2)

Country Link
KR (1) KR20120122705A (en)
WO (1) WO2012148140A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11168081B2 (en) 2017-07-25 2021-11-09 Seoul National University R&Db Foundation Alkaloid derivative having angiogenesis inhibitory effect, and pharmaceutical composition containing same
CN108623524B (en) * 2018-04-17 2021-02-26 安徽农业大学 Imidazole dimer alkaloid, and preparation method and application thereof
CN112888677A (en) 2018-08-16 2021-06-01 先天肿瘤免疫公司 Substituted 4-amino-1H-imidazo [4,5-c ] quinoline compounds and improved process for their preparation
KR20210091865A (en) 2020-01-14 2021-07-23 서울대학교산학협력단 N-phenylbenzothiazol-2-amine Compounds Having Vascular Tube Formation Inhibition Effect and Pharmaceutical Composition Comprising the Same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100404580B1 (en) * 2000-04-20 2003-11-05 한국해양연구원 Wondonin A and Process for Preparing the Same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100404580B1 (en) * 2000-04-20 2003-11-05 한국해양연구원 Wondonin A and Process for Preparing the Same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHANG, Y. H. ET AL.: "Dihydroxystyrene Metabolites from an Association of the Sponges Poecillastra wondoensis and Jaspis sp", J. NAT. PROD., vol. 71, no. 5, 12 April 2008 (2008-04-12), pages 779 - 783 *

Also Published As

Publication number Publication date
KR20120122705A (en) 2012-11-07
WO2012148140A2 (en) 2012-11-01

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