IN2012DN04868A - - Google Patents

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Publication number
IN2012DN04868A
IN2012DN04868A IN4868DEN2012A IN2012DN04868A IN 2012DN04868 A IN2012DN04868 A IN 2012DN04868A IN 4868DEN2012 A IN4868DEN2012 A IN 4868DEN2012A IN 2012DN04868 A IN2012DN04868 A IN 2012DN04868A
Authority
IN
India
Prior art keywords
compounds
compound
formula
methods
preparation
Prior art date
Application number
Inventor
Wei-Guo Su
Weihan Zhang
Hong Jia
Yumin Cui
Yongxin Ren
Yang Sai
Zhenping Wu
Wenji Li
Jiangyong Shao
Zhenping Tian
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44029398&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2012DN04868(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of IN2012DN04868A publication Critical patent/IN2012DN04868A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

Abstract

Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.
IN4868DEN2012 2009-11-23 2010-11-23 IN2012DN04868A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2009101992592A CN102070618B (en) 2009-11-23 2009-11-23 Compound and crystals thereof
PCT/CN2010/078997 WO2011060746A1 (en) 2009-11-23 2010-11-23 Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

Publications (1)

Publication Number Publication Date
IN2012DN04868A true IN2012DN04868A (en) 2015-09-25

Family

ID=44029398

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4868DEN2012 IN2012DN04868A (en) 2009-11-23 2010-11-23

Country Status (18)

Country Link
US (2) US8658658B2 (en)
EP (1) EP2504331B1 (en)
JP (1) JP5758399B2 (en)
KR (1) KR101513784B1 (en)
CN (2) CN102070618B (en)
AU (1) AU2010321366B2 (en)
BR (1) BR112012012138B1 (en)
CA (1) CA2781066C (en)
DK (1) DK2504331T3 (en)
ES (1) ES2529105T3 (en)
IN (1) IN2012DN04868A (en)
MX (1) MX2012005926A (en)
MY (1) MY161749A (en)
NZ (1) NZ600266A (en)
PL (1) PL2504331T3 (en)
PT (1) PT2504331E (en)
RU (1) RU2507203C1 (en)
WO (1) WO2011060746A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102070618B (en) * 2009-11-23 2013-08-21 和记黄埔医药（上海）有限公司 Compound and crystals thereof
CA2952857A1 (en) * 2014-06-19 2015-12-23 Merial, Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
CN105985326B (en) * 2015-02-16 2020-04-14 上海宣创生物科技有限公司 Pyrimidine derivative crystal form III and preparation method and application thereof
WO2016187767A1 (en) * 2015-05-25 2016-12-01 Hutchison Medipharma Limited Pharmaceutical compositions and use thereof
US20190276439A1 (en) * 2016-11-18 2019-09-12 Hutchison Medipharma Limited Method of treating solid tumors
JP2020164434A (en) * 2019-03-28 2020-10-08 上野製薬株式会社 Production method of 2,6-naphthalenebis(2-oxazoline)
WO2021180027A1 (en) * 2020-03-09 2021-09-16 和记黄埔医药（上海）有限公司 Pharmaceutical combination of anti-pd-1 antibody and multi-receptor tyrosine kinase inhibitor and method for using same
US20240043409A1 (en) * 2021-04-12 2024-02-08 Mitoimmune Therapeutics Inc. Crystalline forms of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indol-7-amine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090036448A1 (en) * 2004-03-30 2009-02-05 Taisho Pharmecutical Co., Ltd. Pyrimidine derivatives and methods of treatment related to the use thereof
WO2007035309A1 (en) 2005-09-15 2007-03-29 Merck & Co., Inc. Tyrosine kinase inhibitors
CN101289444B (en) * 2007-04-16 2012-01-04 和记黄埔医药（上海）有限公司 Pyrimidine derivate and medicinal use thereof
TWI484960B (en) * 2007-04-16 2015-05-21 Hutchison Medipharma Entpr Ltd Pyrimidine derivatives
TW201008933A (en) * 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds
CN102070618B (en) 2009-11-23 2013-08-21 和记黄埔医药（上海）有限公司 Compound and crystals thereof

Also Published As

Publication number Publication date
EP2504331A1 (en) 2012-10-03
BR112012012138A2 (en) 2017-03-07
CN102648194B (en) 2014-10-29
KR20120097526A (en) 2012-09-04
CA2781066A1 (en) 2011-05-26
PT2504331E (en) 2015-02-20
ES2529105T3 (en) 2015-02-16
US20120270889A1 (en) 2012-10-25
CN102070618B (en) 2013-08-21
PL2504331T3 (en) 2015-04-30
DK2504331T3 (en) 2014-12-08
EP2504331B1 (en) 2014-11-12
WO2011060746A1 (en) 2011-05-26
CA2781066C (en) 2014-09-16
BR112012012138B1 (en) 2023-02-07
RU2507203C1 (en) 2014-02-20
JP5758399B2 (en) 2015-08-05
CN102070618A (en) 2011-05-25
US8946249B2 (en) 2015-02-03
US20140200232A1 (en) 2014-07-17
EP2504331A4 (en) 2013-04-17
AU2010321366B2 (en) 2014-07-24
NZ600266A (en) 2014-06-27
AU2010321366A1 (en) 2012-06-14
AU2010321366A8 (en) 2012-07-05
MX2012005926A (en) 2012-11-23
JP2013511475A (en) 2013-04-04
KR101513784B1 (en) 2015-04-20
CN102648194A (en) 2012-08-22
MY161749A (en) 2017-05-15
RU2012126112A (en) 2013-12-27
US8658658B2 (en) 2014-02-25

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