WO2012128582A3 - A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME - Google Patents

A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME Download PDF

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Publication number
WO2012128582A3
WO2012128582A3 PCT/KR2012/002100 KR2012002100W WO2012128582A3 WO 2012128582 A3 WO2012128582 A3 WO 2012128582A3 KR 2012002100 W KR2012002100 W KR 2012002100W WO 2012128582 A3 WO2012128582 A3 WO 2012128582A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
same
compound
dehydrogenase type
steroid dehydrogenase
Prior art date
Application number
PCT/KR2012/002100
Other languages
French (fr)
Other versions
WO2012128582A2 (en
Inventor
In Hee Lee
Chang Min Park
Se Hoan Kim
Hee Il Chae
Doo Hyeok PYEON
Myoung Hyeon SHIN
Jeong Un HWANG
Soon Young Moon
Tae Young Ha
So Youn Kim
Hyuk Joon Choi
Myoung Hyun YOO
Jong Chan Lee
Young Seok Kim
Jae Keol Rhee
Original Assignee
Hyundai Pharm Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020110025926A external-priority patent/KR20120108999A/en
Priority claimed from KR1020120020455A external-priority patent/KR20120109297A/en
Application filed by Hyundai Pharm Co., Ltd. filed Critical Hyundai Pharm Co., Ltd.
Publication of WO2012128582A2 publication Critical patent/WO2012128582A2/en
Publication of WO2012128582A3 publication Critical patent/WO2012128582A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.
PCT/KR2012/002100 2011-03-23 2012-03-23 A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME WO2012128582A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR10-2011-0025920 2011-03-23
KR1020110025926A KR20120108999A (en) 2011-03-23 2011-03-23 A COMPOUND FOR INHIBITING 11 ß-HYDROXY STEROID DEHYDROGENASE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
KR20110025920 2011-03-23
KR10-2011-0025926 2011-03-23
KR1020120020455A KR20120109297A (en) 2011-03-23 2012-02-28 A COMPOUND FOR INHIBITING 11 ß-HYDROXY STEROID DEHYDROGENASE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
KR10-2012-0020455 2012-02-28

Publications (2)

Publication Number Publication Date
WO2012128582A2 WO2012128582A2 (en) 2012-09-27
WO2012128582A3 true WO2012128582A3 (en) 2012-11-15

Family

ID=46879919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/002100 WO2012128582A2 (en) 2011-03-23 2012-03-23 A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Country Status (1)

Country Link
WO (1) WO2012128582A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6483666B2 (en) 2013-10-14 2019-03-13 エーザイ・アール・アンド・ディー・マネジメント株式会社 Selectively substituted quinoline compounds
MY192489A (en) 2013-10-14 2022-08-23 Eisai R&D Man Co Ltd Selectively substituted quinoline compounds
NZ731118A (en) 2014-10-31 2023-05-26 Indivior Uk Ltd Dopamine d3 receptor antagonists compounds
US11155539B2 (en) * 2018-10-17 2021-10-26 Boehringer Ingelheim International Gmbh 4-pyridinylmethyl-morpholine derivatives and the use thereof as medicament
US11166958B2 (en) * 2018-10-17 2021-11-09 Boehringer Ingelheim International Gmbh 4-pyrazin-2-ylmethyl-morpholine derivatives and the use thereof as medicament
US11104670B2 (en) * 2018-10-17 2021-08-31 Boehringer Ingelheim International Gmbh 4-pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament
GB202108544D0 (en) * 2021-06-15 2021-07-28 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency
CN114276280B (en) * 2021-10-30 2023-10-31 苏州汉酶生物技术有限公司 Preparation method of chiral phenterminol sulfonamide compound, intermediate for preparing chiral phenterminol sulfonamide compound and preparation method of chiral phenterminol sulfonamide compound

Citations (5)

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Publication number Priority date Publication date Assignee Title
US20050154024A1 (en) * 2003-12-22 2005-07-14 Pfizer Inc Compounds useful in therapy
WO2006023844A2 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
JP2006131559A (en) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd Nitrogen-containing heterocyclic compound
WO2006077025A2 (en) * 2005-01-18 2006-07-27 F. Hoffmann-La Roche Ag Morpholines as 5ht2c agonists
JP2011016742A (en) * 2009-07-07 2011-01-27 Astellas Pharma Inc Cyclic amino compound, or salt thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050154024A1 (en) * 2003-12-22 2005-07-14 Pfizer Inc Compounds useful in therapy
WO2006023844A2 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
JP2006131559A (en) * 2004-11-05 2006-05-25 Takeda Chem Ind Ltd Nitrogen-containing heterocyclic compound
WO2006077025A2 (en) * 2005-01-18 2006-07-27 F. Hoffmann-La Roche Ag Morpholines as 5ht2c agonists
JP2011016742A (en) * 2009-07-07 2011-01-27 Astellas Pharma Inc Cyclic amino compound, or salt thereof

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE PUBCHEMCOMPOUND accession no. 3089177 *
DATABASE PUBCHEMCOMPOUND accession no. 3188324 *
DATABASE PUBCHEMCOMPOUND accession no. 3825918 *
DATABASE PUBCHEMCOMPOUND accession no. 564672 *
DATABASE PUBCHEMCOMPOUND accession no. 5651196 *
DATABASE PUBCHEMCOMPOUND accession no. 6243994 *
DATABASE PUBCHEMCOMPOUND accession no. 6737160 *
DATABASE PUBCHEMCOMPOUND accession no. 9417584 *
DATABASE PUBCHEMCOMPOUND retrieved from URL: http://pubchem.ncbi.nlm.nih.gov/search/search.cgi accession no. 1104591 *

Also Published As

Publication number Publication date
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