WO2012128129A1 - Puncturing needle, medicine administration apparatus, and syringe pump - Google Patents
Puncturing needle, medicine administration apparatus, and syringe pump Download PDFInfo
- Publication number
- WO2012128129A1 WO2012128129A1 PCT/JP2012/056456 JP2012056456W WO2012128129A1 WO 2012128129 A1 WO2012128129 A1 WO 2012128129A1 JP 2012056456 W JP2012056456 W JP 2012056456W WO 2012128129 A1 WO2012128129 A1 WO 2012128129A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- needle
- lumen
- outer needle
- inner needle
- puncture
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1583—Needle extractors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1587—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body suitable for being connected to an infusion line after insertion into a patient
Definitions
- the present invention relates to a puncture needle that is punctured into a living tissue, a drug administration device that administers a drug to the living tissue, and a syringe pump.
- EUS-FNI Edoscopic Ultrasonography guided Needle Injection: ultrasound endoscopic drug solution injection
- EUS-FNI ultrasound endoscopic drug solution injection
- the present invention has been made in view of the above, and an object thereof is to provide a puncture needle, a drug administration device, and a syringe pump that can realize easy multipoint administration of a predetermined amount of drug.
- a puncture needle is a puncture needle that is punctured into a living tissue, has a first lumen inside, and is provided on the side surface on the distal end side.
- An outer needle provided with an opening communicating with the first lumen; an inner needle having a second lumen inside; and at least a distal end portion inserted through the first lumen of the outer needle so as to be capable of moving forward and backward.
- the inner needle has a first state in which the tip portion is accommodated in the first lumen of the outer needle by the forward and backward movement, and at least one of the tip portions from the opening of the outer needle. A transition is made between the second state in which the portion protrudes.
- the puncture needle according to the present invention is characterized in that, in the above-mentioned invention, the tip of the inner needle forms an acute angle when it protrudes from the opening of the outer needle.
- the puncture needle in the above invention, when the inner needle moves forward with respect to the first lumen of the outer needle, a part of the tip portion of the inner needle protrudes,
- the outer needle has a guide surface on the first lumen for guiding the tip of the inner needle from the first lumen to the opening.
- the puncture needle according to the present invention is characterized in that, in the above invention, a plurality of the openings are provided on a side surface of the outer needle.
- the puncture needle according to the present invention is characterized in that, in the above-mentioned invention, the plurality of openings have different positions in the longitudinal direction of the outer needle.
- the puncture needle according to the present invention is characterized in that, in the above invention, the inner needle has a tip branched corresponding to the plurality of openings.
- the outer needle has a guide surface for guiding the tip of the inner needle from the first lumen to the opening, and the first lumen has the opening.
- Each guide surface has an inclination of a different angle.
- the puncture needle according to the present invention is characterized in that, in the above-mentioned invention, a marker is attached on an extension line extending in the axial direction of the opening of the outer needle toward the proximal end.
- the puncture needle in the above invention, when the inner needle is in the first state, the movement of the inner needle and the rotational movement about the longitudinal axis of the outer needle are linked. It is characterized by further comprising a cooperation mechanism to be made.
- the cooperation mechanism causes the outer needle to rotate by the advance and retreat of the inner needle when the inner needle is in the first state.
- An engagement mechanism is included.
- the puncture needle according to the present invention is characterized in that, in the above invention, the engagement mechanism includes an engagement pin and a cam groove, and the engagement pin engages with the cam groove. .
- the cam groove includes a plurality of linear grooves extending in an axial direction, a base end of each linear groove, and one linear groove adjacent to each linear groove. It is characterized by being formed by a plurality of inclined grooves that respectively connect the front ends of the plurality of slanted grooves and that obliquely connect the plurality of linear grooves.
- the engagement pin is provided on a connection member that is connected to the outer needle and that moves forward according to the forward movement of the inner needle.
- the outer needle is rotated by advancing the inclined groove of the cam groove by advancing.
- the puncture needle according to the present invention is characterized in that, in the above-described invention, the puncture needle further includes a biasing mechanism that biases the outer needle to rotate in a certain direction.
- the cooperation mechanism causes the outer needle to rotate by the rotation of the inner needle when the inner needle is in the first state. It has an engagement mechanism.
- the engagement mechanism may include an engagement pin provided on one of the outer surface of the inner needle and the inner surface of the first lumen of the outer needle. And an engaged member provided on the other of the outer surface of the inner needle and the inner surface of the first lumen of the outer needle, and the engaging pin and the engaged member are configured such that the inner needle is the first member.
- the outer needle has a positional relationship to be engaged when it is in the section 1, and the rotational movement of the inner needle is transmitted to the outer needle by the engagement of the engagement pin and the engaged member. Rotational motion occurs in
- the puncture needle according to the present invention is the puncture needle according to the above invention, wherein the outer needle is positioned around the axis of the outer needle with respect to the proximal end portion while the proximal end portion, the opening and the cooperation mechanism are located.
- a distal end portion that is movable, and the distal end portion of the outer needle is configured to rotate with respect to the proximal end portion by the cooperation mechanism.
- the inner needle is connected to a syringe pump at a proximal end, and the syringe pump includes a plunger having an external thread formed on an outer surface and a female on an inner surface. And a syringe having a screw formed thereon.
- the drug administration device is a drug administration device having a puncture needle that is punctured into a living tissue and a drug delivery unit that delivers the drug to the puncture needle, and the puncture needle has a first inside.
- An outer needle having an opening communicating with the first lumen on the side surface on the distal end side, a second lumen inside, and at least a distal end portion of the first lumen of the outer needle.
- the second lumen of the inner needle And a pressure for delivering a drug to the delivery pump when at least the inner needle is in the second state and the inner needle is retracted relative to the outer needle.
- a control unit for controlling the operation.
- the syringe pump according to the present invention is characterized by comprising a plunger having a male screw formed on the outer surface and a syringe having a female screw formed on the inner surface.
- the fitting between the male screw formed on the plunger and the female screw formed on the inner surface of the syringe is configured to be releasable. It is characterized by that.
- the puncture needle has a first lumen inside, an outer needle provided with an opening communicating with the first lumen on the side surface on the distal end side, And an inner needle having at least a distal end portion inserted through the first lumen of the outer needle so as to be capable of moving forward and backward.
- the inner needle is moved forward and backward to move the first lumen of the outer needle.
- the inner needle protrudes from the opening of the outer needle because the transition between the first state in which the distal end is accommodated in the second state and the second state in which at least a part of the distal end protrudes from the opening of the outer needle can be made.
- the syringe pump according to the present invention since it includes the plunger with the external thread formed on the outer surface and the syringe with the internal thread formed on the inner surface, by controlling the rotation speed of the plunger, Even medicines can be discharged accurately.
- FIG. 1 is a diagram for explaining drug administration to a living tissue by the drug administration device according to the first embodiment.
- FIG. 2 is a perspective view of the distal end portion of the puncture needle shown in FIG.
- FIG. 3 is a perspective view of the distal end portion of the puncture needle shown in FIG.
- FIG. 4 is a cross-sectional view of the distal end portion of the puncture needle shown in FIG. 2 cut along the central axis in the longitudinal direction of the puncture needle.
- FIG. 5 is a cross-sectional view of the distal end portion of the puncture needle shown in FIG. 3 cut along the central axis in the longitudinal direction of the puncture needle.
- FIG. 6 is a cross-sectional view of a portion of the puncture needle shown in FIG.
- FIG. 7 is a perspective view showing a main part and a plunger of the syringe shown in FIG.
- FIG. 8 is a flowchart showing a procedure of a drug administration process using the drug administration device shown in FIG.
- FIG. 9 is a perspective view of the puncture needle and gripping portion shown in FIG.
- FIG. 10 is a view for explaining a drug administration locus of the drug administration device shown in FIG.
- FIG. 11 is an exploded perspective view of the syringe and the plunger in the first modification of the first embodiment.
- FIG. 12 is an exploded perspective view of the syringe and the plunger in the first modification of the first embodiment.
- FIG. 13 is a schematic diagram illustrating the configuration of the drug administration device according to the second modification of the first embodiment.
- FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
- FIG. 15 is a cross-sectional view of the distal end portion of another puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
- FIG. 16 is an exploded perspective view of the drug administration device according to the second embodiment.
- FIG. 17 is a cross-sectional view of the main part on the proximal end side of the drug administration device shown in FIG. 16 cut along the central axis in the longitudinal direction.
- FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
- FIG. 15
- FIG. 18 is a cross-sectional view of the main part on the proximal end side of the drug administration device shown in FIG. 16 cut along the central axis in the longitudinal direction.
- FIG. 19 is a cross-sectional view taken along line AA in FIG.
- FIG. 20 is a diagram showing cam grooves formed on the inner surface of the base cavity shown in FIG.
- FIG. 21 is a cross-sectional view of the base-end-side main part of the drug administration device according to the third embodiment, cut along the central axis in the longitudinal direction.
- FIG. 22 is a perspective view of the distal end portion of the puncture needle in the fourth embodiment.
- FIG. 23 is a perspective view of the distal end portion of the puncture needle in the fourth embodiment.
- FIG. 24 is a cross-sectional view of the tip portion of the puncture needle shown in FIG. 22 cut along the central axis in the longitudinal direction of the puncture needle.
- FIG. 25 is a cross-sectional view of the tip portion of the puncture needle shown in FIG. 23 cut along the central axis in the longitudinal direction of the puncture needle.
- FIG. 26 is a schematic diagram for explaining the shape of the engaged member shown in FIGS. 24 and 25.
- FIG. 27 is a schematic diagram for explaining the shape of another engaged member shown in FIGS. 24 and 25.
- FIG. 28 is a schematic diagram for explaining the shape of the engaged member shown in FIGS. 24 and 25.
- FIG. 1 is a diagram for explaining drug administration to a living tissue by the drug administration device according to the first embodiment.
- a drug administration device 1 includes a puncture needle 2 provided at a distal end and punctured into a living tissue, a gripping portion 3 provided on a proximal end side of the puncture needle 2, and a puncture needle 2. And a syringe 5 for delivering the drug held inside to the tube 4.
- the puncture needle 2 is made of, for example, stainless steel or titanium.
- the tube 4 is made of, for example, silicon, polyethylene, polyurethane, or the like.
- the puncture needle 2 is punctured into an organ 7 located at the back of the body surface 6.
- the operator can administer the medicine stored in the syringe 5 into the organ through the tube 4 and the puncture needle 2 by moving the plunger 8 forward with respect to the syringe 5.
- FIGS. 2 and 3 are perspective views of the distal end portion of the puncture needle 2 shown in FIG.
- FIG. 4 is a cross-sectional view of the distal end portion of the puncture needle 2 shown in FIG. 2 cut along the central axis in the longitudinal direction of the puncture needle 2.
- FIG. 5 is a cross-sectional view of the tip portion of the puncture needle 2 shown in FIG. 3 cut along the central axis in the longitudinal direction of the puncture needle 2.
- the puncture needle 2 includes an outer needle 10 and an inner needle 11.
- the outer needle 10 has a first lumen 12 inside, an opening 13 communicating with the first lumen 12 is provided on the side surface on the tip side, and has an elongated shape with a pointed tip.
- the outer needle 10 is cut by facing a circle with the central axis in the longitudinal direction, the outer surface forms a circle.
- the inner needle 11 is inserted through the first lumen 12 of the outer needle 10 at least at the tip so as to be able to advance and retreat.
- the inner needle 11 can move forward and backward with respect to the first lumen 12.
- the inner needle 11 has a second lumen 14 with an open end.
- the inner needle 11 is connected to the tube 4, and the second lumen 14 communicates with the inner lumen of the tube 4.
- the internal lumen of the tube 4 communicates with the internal space of the syringe 5.
- the second lumen 14 functions as a passage through which the medicine, physiological saline and the like held in the syringe 5 are conveyed, and the medicine, physiological saline and the like are discharged from the opening 11a at the tip of the inner needle 11.
- the outer needle 10 and the gripping part 3 are formed integrally, for example, and the operator grips the gripping part 3 and operates the gripping part 3 to move the outer needle 10 to the living body. It is possible to puncture the tissue and rotate the outer needle 10 around the axis.
- the inner needle 11 is in a first state in which the distal end portion of the inner needle 11 is accommodated in the first lumen 12 of the outer needle 10 by the forward and backward movement of the inner needle 11 (see FIGS. 2 and 4), A transition is made between the second state (see FIGS. 3 and 5) in which at least a part of the tip of the inner needle 11 protrudes from the opening 13 of the outer needle 10.
- the inner needle 11 advances from the first lumen 12 to move the inner needle 11 from the opening 13 of the outer needle 10 from the first state where the distal end portion of the inner needle 11 is accommodated in the first lumen 12 of the outer needle 10. It changes to the 2nd state from which a part of tip part of needle 11 protrudes.
- the outer needle 10 has a guide surface 10 a for guiding the tip of the inner needle 11 from the first lumen 12 to the opening 13 in the first lumen 12.
- the guide surface 10 a is an inclined surface that is inclined from the distal end side end portion of the opening 13 toward the proximal end side. Based on the protruding length of the inner needle 11 and the position where the drug is to be administered so that the tip position of the protruding inner needle 11 reaches the position where the drug is to be administered when the distal end of the inner needle 11 is projected the longest.
- the inclination angle of the guide surface 10a is set.
- the outer angle forms an acute angle.
- the tip of the inner needle 11 protruding from the opening 13 can easily enter the living tissue while opening the living tissue around the outer needle 10, so that the inner needle 11 extends from the opening toward the outside of the outer needle 10. Can protrude.
- a stopper 15 is provided on the first lumen 12 of the outer needle 10 so as to be separated by a predetermined distance (between the position P and the position Q).
- a protrusion 16 is provided on the outer side surface of the inner needle 11 and is positioned between the front and rear stoppers 15. The range in which the inner needle 11 can move in the first lumen 12 by the contact of the protrusion 16 of the inner needle 11 with the stopper 15 is limited. Therefore, in the puncture needle 2, the inner needle 11 does not protrude excessively from the outer needle 10 and the inner needle 11 is not pulled out by mistake.
- FIG. 7 is a perspective view showing the main part of the syringe 5 and the plunger 8 shown in FIG.
- a male screw 8 a is formed in a region inserted into the syringe 5 on the outer surface of the plunger 8.
- a female screw 5 a that fits into the male screw 8 a of the plunger 8 is formed.
- the plunger 8 is rotated with respect to the syringe 5 so as to advance toward the distal end side of the syringe 5, thereby discharging the medicine or the like from the distal end of the syringe 5.
- 12.5 microliters of medicine or the like can be discharged from the tip of the syringe 5. Therefore, according to the syringe 5 and the plunger 8, by controlling the number of rotations of the plunger 8, it is possible to accurately discharge a small amount of medicine or the like.
- Markers 5b and 8b are provided at the proximal end of the syringe 5 and the proximal end of the plunger 8 so that the amount of rotation of the plunger 8 relative to the syringe 5 can be determined.
- the plunger 8 and the syringe 5 are fitted with each other with the male screw 8a and the female screw 5a, the plunger 8 maintains the position as it is with respect to the syringe 5 even when the force for pushing the plunger 8 is lost. , never pushed out. Therefore, the operator can release his / her hand from the plunger 8 even while the medicine is being discharged.
- FIG. 8 is a flowchart showing a procedure of a drug administration process using the drug administration device 1 shown in FIG.
- step S1 after the distal end portion of the inner needle 11 is housed in the first lumen 12 inside the outer needle 10 (step S1), the outer needle 10 is moved to the first state (see FIGS. 2 and 4). The living tissue is punctured and the tip of the outer needle 10 is introduced into the organ 7 to be administered with the drug (step S2).
- step S3 In a state where the outer needle 10 is introduced into the living tissue, the operator pushes the tube 4 toward the distal end side to advance the inner needle 11 relative to the outer needle 10, thereby moving the distal end of the inner needle 11. Let it protrude from the opening 13 of the outer needle 10 (step S3), and assume a second state (see FIGS. 3 and 5). By the protruding operation of the tip of the inner needle 11, the living tissue located in the direction in which the tip of the inner needle 11 spreads is cut open by the tip of the inner needle 11, and can be cut.
- the operator rotates the plunger 8 with respect to the syringe 5 so as to advance toward the distal end side of the syringe 5 by a rotation amount corresponding to the discharge amount of the medicine, etc.
- the medicine and the like are discharged from the opening 11a at the tip of the inner needle 11 (step S4).
- the discharged medicine infiltrates into the incision opened by the tip of the inner needle 11.
- step S5 the inner needle 11 is set to the first state.
- step S6 determines whether or not the scheduled number of times of ejection of the medicine has been reached.
- step S6 determines that the scheduled number of ejections of the medicine or the like has not been reached.
- step S7 the operator holds the grip portion 3 and rotates the outer needle 10 by a predetermined angle around the longitudinal axis.
- the operator rotates the outer needle 10 by about 60 ° in one rotation.
- a marker 3a is attached on the extension line in the axial direction.
- the present invention is not limited to the marker 3 a shown in FIG. 9, and a part of the side surface of the grip portion 3 located on the extension line in the axial direction of the opening 13 of the outer needle 10 is cut out and flattened. It may be possible to determine which direction of the direction is currently facing.
- step S3 the process returns to step S3, and the distal end of the inner needle 11 is protruded from the opening 13 of the outer needle 10 in a state where the outer needle 10 is punctured into the living tissue (step S3), and the second state is set. Due to the protruding operation of the tip of the inner needle 11, a cut with an angle different from the previous time is formed in the living tissue.
- step S6 when it is determined that the number of times that the medicine or the like has been ejected has been reached (step S6: Yes), the operator determines whether to extract the outer needle 10 or leave the outer needle 10 in place. (Step S8).
- step S8: extraction When the operator determines that the outer needle 10 is to be extracted (step S8: extraction), the outer needle 10 is extracted from the organ 7 with the inner needle 11 stored in the first lumen 12 inside the outer needle 10 ( Step S9).
- step S8 placement
- the outer needle 10 is placed in the organ 7 as it is (step S10).
- the medicine is ejected from the inner needle 11 with the inner needle 11 protruding from the opening 13, and the outer needle 10 is stored in the opening 13 while the inner needle 11 is housed in the opening 13.
- Multi-point administration can be easily performed by repeating the operation of rotating around a predetermined number of times.
- the plunger 8 and the syringe 5 are fitted with the male screw 8a and the female screw 5a.
- the medicine is ejected on the locus of the inner needle 11 in the organ 7. That is, by repeating the discharge of the medicine or the like from the inner needle by changing the angle as described above, when the inner needle 11 protrudes from the outer needle 10, as shown schematically in FIG. Since the upper portion is located on the circumference L1 of the bottom surface, by repeating the steps shown in FIG. 8 as described above, the medicine is discharged to a plurality of locations on the circumference L1, and a sufficient amount of medicine is held in the medicine administration target region. Can do.
- the outer needle 10 having an outer diameter larger than that of the inner needle 11 is attached to the living tissue only when the puncture needle 2 is introduced into the living tissue and when the puncture needle 2 is extracted from the living tissue. Move forward and backward. Therefore, according to the first embodiment, multipoint administration to a plurality of locations in the organ 7 can be realized while reducing the invasion of the organ 7 by the outer needle 10 having a large outer diameter.
- step S4 and step S5 in FIG. 8 described above may be performed in parallel. That is, when the inner needle 11 is moved backward with respect to the outer needle 10, the plunger 8 is rotated with respect to the syringe 5, and the inner needle 11 is moved backward while maintaining the pressure of the medicine. You may make it discharge a chemical
- FIG. By operating in this way, as schematically shown in FIG. 10, in addition to the space formed in the locus of the retreating inner needle 11, that is, the substantially conical bottom circumference L1 in FIG. Since the medicine corresponding to the side surface L2 of the shape can be filled with the medicine, the filling efficiency of the medicine into the living tissue can be increased.
- a contact portion 105a is formed on the grip at the base end so that the inside contacts the male screw 8a of the plunger 8.
- a protrusion 105b into which one end of the spring 107 is fitted is formed on the outside of the contact portion 105a.
- the grip of the syringe 105 is formed with a knob portion 105c in which a part of the grip is extended and bent.
- the engaging member 106 is formed with a female screw portion 106a that can be fitted to the male screw 8a on a part of the opening side surface through which the plunger 8 can be inserted.
- a protruding portion 106 b is formed so as to face the female screw portion 106 a and into which the other end of the spring 107 is fitted.
- the engaging member 106 is formed with a knob portion 106c that is partially extended and bent. The knob portion 105c and the knob portion 106c face each other as shown in FIG.
- the knob portion 105c of the syringe 105 and the knob portion 106c of the engaging member 106 are pinched so as to be pressed inward, whereby the knob portion 106c moves inward, and accordingly, The female screw portion 106a also moves outward.
- the fitting of the female screw portion 106a to the male screw 8a is released, and the plunger 8 becomes free and can move up and down as indicated by the arrow Y2.
- the spring 107 that has been contracted is extended, and the female screw 106a is engaged with the male screw 8a of the plunger 8.
- the drug or the like can be discharged from the syringe 105 by rotating the plunger 8 so as to move forward with respect to the syringe 105 as in the first embodiment.
- the plunger 8 can be detached from the syringe 105 by simply pinching the knob portion 105c and the knob portion 106c, processing such as drug replenishment processing into the syringe 105 is also easily performed. be able to.
- the drug administration device 1a includes a pump 17 and a reservoir 18 that stores a drug instead of the syringe 5 and the plunger 8 illustrated in FIG. 1. It has a drug delivery unit.
- the pump 17 has a function of sending the medicine stored in the reservoir 18 to the inner needle 11.
- This pump 17 is controlled by the control unit 19 for delivery processing.
- a sensor 20 that detects the relative positional relationship between the outer needle 10 and the inner needle 11 is connected to the control unit 19.
- the control unit 19 Based on the detection result of the sensor 20, the control unit 19 detects that the inner needle 11 is in the second state in which the tip portion protrudes from the opening of the outer needle 10, and the inner needle 11 moves forward most. At the position where the inner needle 11 has reached the most advanced position once, or when it is detected that the inner needle 11 is retracted toward the opening 13 of the outer needle 10, The pump 17 is controlled to deliver.
- the relative position between the outer needle 10 and the inner needle 11 is detected by the sensor 20, and the medicine is automatically ejected according to the detected position. Since the medicine can be automatically administered at the advanced position and the medicine can be filled into the space formed in the backward locus of the inner needle 11, the filling efficiency of the medicine into the living tissue can be increased.
- FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle in Modification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
- the outer needle 10A As shown in FIG. 14, the outer needle 10A according to the third modification of the first embodiment has first lumens 12a and 12b inside, and openings 13a and 13b communicating with the first lumens 12a and 12b, respectively.
- the inner needles 11A and 11B are inserted through the first lumens 12a and 12b, respectively.
- the two inner needles 11A and 11B can be moved forward and backward independently, and at the proximal end (not shown), a tube and a syringe are connected to each other, and drug administration is performed independently.
- the plurality of first lumens 12a and 12b and the openings 13a and 13b are provided, and the advancing / retreating movements and the drug administration process in the inner needles 11A and 11B are independently controlled, so that the plurality of locations in the organ 7 Can be easily realized.
- the inner first lumen 12c may be branched at the tip.
- the first lumen 12c is branched asymmetrically to communicate with the branched first lumens 12c, and the openings 13c and 13d having different positions in the longitudinal direction of the outer needle 10C are provided on the side surfaces of the outer needle 10C. It may be provided.
- an inner needle 11C having a second lumen 14c and having a distal end branched corresponding to the plurality of openings 13c and 13d is used.
- a guide surface 10c for guiding one tip 11c of the inner needle 11C from the first lumen 12c to the opening 13c, and a guide surface 10d for guiding the other tip 11d of the inner needle 11C from the first lumen 12c to the opening 13d. May be formed so as to be inclined at different angles, thereby changing the protrusion angle of the tips 11c and 11d of the inner needle 11C from the openings 13c and 13d.
- Embodiment 2 Next, a second embodiment will be described.
- the movement of the inner needle and the center of the longitudinal axis of the outer needle are only when the inner needle is in the first state in which the tip of the inner needle is accommodated in the first lumen of the outer needle.
- the case where the cooperation mechanism which cooperates rotational movement is provided is demonstrated.
- FIG. 16 is an exploded perspective view of the drug administration device according to the second embodiment.
- 17 and 18 are cross-sectional views of the main part on the proximal end side of the drug administration device 201 shown in FIG. 16 cut along the central axis in the longitudinal direction.
- FIG. 17 shows a state in which the main part on the proximal end side of the drug administration device 201 is disassembled.
- FIG. 18 shows a state in which the main part of the proximal end of the drug administration device 201 is assembled, and shows a state in which a pusher described later is pushed most into a plunger described later.
- the drug administration device 201 includes an outer needle 10 that can accommodate the inner needle 11 therein, an outer cylinder 202 that accommodates the outer needle 10 in the inner lumen, and a substantially cylindrical base member 222. And a substantially cylindrical charge grip 223.
- the charge grip 223 has a non-slip groove formed on the outer periphery. Further, the charge grip 223 has a structure that can rotate with respect to the base member 222.
- the inner cavity of the base member 222 has different inner diameters on the distal end side and the proximal end side, and the proximal end side cavity 222a has a larger diameter.
- a cam groove 228 that goes around the inner surface is formed on the inner surface of the cavity 222a.
- the cam groove 228 is a groove that connects a plurality of linear grooves extending in the axial direction, a base end of each linear groove, and a tip of one linear groove adjacent to each linear groove. Are formed by a plurality of inclined grooves that are diagonally connected to each other.
- the tip of the base member 222 is connected to the outer cylinder 202.
- the outer cylinder 202 accommodates the outer needle 10 in a lumen so as to be rotatable.
- the outer cylinder 202 is, for example, a PEEK resin tube.
- the syringe 224 has a hollow inside, and has a small-diameter portion 224a in which at least a tip portion is rotatably accommodated in the cavity 222a of the base member 222, and a large-diameter portion 224b having a large diameter connected to the small-diameter portion 224a.
- the proximal end of the outer needle 10 is connected to the distal end of the small diameter portion 224a.
- a linear guide groove 226 extending in the longitudinal axis direction is formed on the inner surface of the cavity 224c inside the large diameter portion 224b.
- An engaging pin 229 that can engage with the cam groove 228 is provided on the outer surface of the small diameter portion 224a. As shown by the arrow in FIG. 17, the engaging pin 229 is urged so as to protrude to the outside, and is configured to be accommodated in the outer wall of the small-diameter portion 224a when pushed from above. Is done.
- the distal end portion of the syringe 224 is a cavity of the base member 222 until the received engaging pin 229 reaches the cam groove 228 of the base member 222 in a state where the engaging pin 229 is received in the outer wall of the small diameter portion 224a. 222a is inserted.
- the engaging pin 229 biased in the outward direction protrudes when it reaches the cam groove 228 and engages with the cam groove 228.
- the engaging pin 229 can move in the groove of the cam groove 228 to make a round of the inner surface of the base member 222.
- the syringe 224 main body can also rotate along the contour of the cam groove 228. Since the proximal end of the outer needle 10 is connected to the distal end of the small diameter portion 224a, the outer needle 10 also rotates integrally with the syringe 224.
- the plunger 225 has a substantially cylindrical shape, and at least a tip portion is rotatably accommodated in the cavity 224c of the syringe 224.
- An engagement pin 227 that engages with the guide groove 226 of the syringe 224 is provided on the outer surface of the plunger 225.
- the proximal end of the inner needle 11 is connected to the distal end of the plunger 225, and the plunger 225 and the inner needle 11 move integrally.
- the pusher 225a is inserted into the cavity 224c of the plunger 225 from the proximal end side of the plunger 225, and is pushed toward the distal end side by the operator when the medicine is discharged.
- a tube 204 connected to the reservoir 18 is connected to the side surface on the proximal end side of the pusher 225a.
- the one-way valve 234 allows a drug or the like in the tube 204 to pass into the plunger 225 when pressure in the direction from the tube 204 into the plunger 225 is applied.
- the one-way valve 234 allows the medicine or the like to pass into the cavity of the plunger 225 when the pusher 225 a is pulled out from the plunger 225.
- a one-way valve 235 is provided at the distal end of the cavity of the plunger 225 so that when a force in the direction from the plunger 225 toward the distal direction is applied, the medicine in the plunger 225 passes in the direction toward the outside. It is done. That is, the one-way valve 235 discharges the medicine or the like in the plunger 225 from the tip of the plunger 225 when the pusher 225a is pushed into the plunger 225.
- a first spring 230 is disposed on the outer surface of the syringe 224.
- the front end side edge part 230a is being fixed to the base end side bottom face of the charge grip 223, and the base end side end part 230b is being fixed to the large diameter part 224b of the syringe 224.
- FIG. 19 is a sectional view taken along line AA of FIG.
- a hole 222 d is formed on the outer surface of the base member 222 on the tip side of the cam groove 228.
- a hole 223 b is formed on the inner side surface of the charge grip 223 on the tip side of the cam groove 228.
- the holes 222d and 223b are engaged by an engaging member 232 interposed therebetween, and the charge grip 223 rotates in one direction with respect to the base member 222, but rotates in the opposite direction. It is configured not to.
- the engaging member 232 is formed as a set of one spring and one ball.
- the engaging member 232 engages the base member 222 and the charge grip 223, when the charge grip 223 and the syringe 224 are rotated in a rotatable direction, the energy of rotation is applied to the first spring 230. Charged. Since the outer needle 10 is connected to the syringe 224, the engaging member 232 shown in FIG. 19 functions as an urging mechanism that urges the outer needle 10 to rotate in a certain direction.
- a second spring 231 is disposed on the outer surface of the plunger 225.
- the base end side edge part is being fixed to the base end of the plunger 225, and the front end side edge part is not being fixed so that a movement becomes free.
- a third spring 233 is disposed on the pusher 225a. When the pusher 225a is pushed into the plunger 225, the third spring 233 contracts to charge energy in the proximal direction, and the pusher 225a is urged in the pushing back direction.
- the second spring 231 is a spring having stronger elasticity than the first spring 230.
- the third spring 233 is a spring having even stronger elasticity than the second spring 231.
- FIG. 20 is a diagram illustrating the cam groove 228 formed on the inner surface of the cavity 222 a of the base member 222.
- the engagement pin 229 is located at the position A (see FIG. 20).
- the force pushing the pusher 225a is transmitted to the syringe 224 via the third spring 233 and the second spring 231 and becomes the force pushing the syringe 224.
- the engaging pin 229 is also pushed to the tip side, and the engaging pin 229 moves along the inclined groove portion of the cam groove 228 to the position B of the cam groove 228. To do.
- the syringe 224 also rotates within the cavity 222a of the base member 222.
- the angle at which the syringe 224 rotates when viewed from a plane orthogonal to the paper surface of FIG. 18 is preferably, for example, 30 ° to 180 °. Then, as the syringe 224 is pushed, the first spring 230 contracts.
- the force pushing the pusher 225a is transmitted to the plunger 225 via the third spring 233 and pushes the plunger 225, and the plunger 225 moves forward in the syringe 224 toward the distal end.
- the second spring 231 provided on the outer surface of the plunger 225 starts to contract.
- the engaging pin 227 advances to the tip of the guide groove 226, and accordingly, the inner needle 11 connected to the tip of the plunger 225 also advances, and the tip of the inner needle 11 protrudes from the opening 13 of the outer needle 10.
- the protrusion of the tip of the inner needle 11 stops when the advance of the engagement pin 227 stops at the tip of the guide groove 226.
- the member that is urged by the second spring 231 and the third spring 233 is provided with a stopper in advance to limit the stroke, that is, a state in which a slight pressing force is applied to the distal end side even before the operation is started. May be.
- the movement of each member related to the contraction of the second spring 231 and the third spring 233 starts after the movement related to one spring is completed, and thus the movement related to the next spring is started.
- the member operates more regularly. That is, the second spring 231 starts to contract after the movement of the member related to the contraction of the first spring 230 (the rotation operation of the syringe 224) is completed.
- the third spring 233 starts to contract after the movement of the member related to the contraction of the second spring 231 (the protruding operation of the inner needle 11) is completed.
- the third spring 233 contracts and the pusher 225a is pushed into the plunger 225.
- a force in the direction from the plunger 225 toward the distal end is applied to the plunger 225, and the medicine or the like in the plunger 225 is discharged from the plunger 225 distal end via the one-way valve 235.
- the medicine or the like discharged from the distal end of the plunger 225 flows through the inner lumen of the inner needle 11 and is discharged toward the living tissue from the distal end of the inner needle 11.
- the force pushing the pusher 225a is released, so that the pusher 225a is first retracted in the proximal direction by the elastic energy stored in the third spring 233. Since the pressure in the direction from the tube 204 into the plunger 225 is applied by the retraction of the pusher 225a, the medicine is supplied from the tube 204 into the plunger 225 via the one-way valve 234.
- the plunger 225 moves backward in the proximal direction by the elastic energy stored in the second spring 231.
- the inner needle 11 connected to the distal end of the plunger 225 is also retracted.
- the tip of the inner needle 11 is accommodated again in the outer needle 10 via the opening 13 of the outer needle 10.
- the elastic energy stored in the first spring 230 causes the syringe 224 to retreat in the proximal direction and return to the initial state.
- the engagement pin 229 moves backward from the position B to the position C in the cam groove 228.
- the outer needle 10 rotates around the axis, the inner needle 11 protrudes from the opening 13 of the outer needle 10, and the inner needle. 11 It is possible to repeat a discharge cycle of the medicine from the tip, supply of the medicine from the tube 204 into the plunger 225, and storage of the inner needle 11 into the opening 13 of the outer needle 10, so Multipoint administration to a plurality of locations can be realized more easily.
- FIG. 21 is a cross-sectional view of the base-end-side main part of the drug administration device according to the third embodiment, cut along the central axis in the longitudinal direction.
- the drug administration device according to the third embodiment has a configuration in which the third spring 233 shown in FIGS. 16 to 18 is omitted as compared with the drug administration device 201 according to the second embodiment.
- the drug administration device 301 has a plunger 8 shown in FIG. 7 as a pusher in place of the pusher 225a shown in FIGS.
- the drug administration device 301 includes a plunger 325 in which a female screw 325 a into which the male screw 8 a of the plunger 8 is fitted is formed in the proximal end side.
- a small amount of medicine can be delivered by rotating the plunger 8 that functions as a pusher with respect to the plunger 325.
- the relative positional relationship between the base member 222, the syringe 224, and the plunger 325 may be locked by a lock mechanism.
- the operator can release his / her hand from the plunger 325.
- medical agent is implement
- the lock mechanism When the operator pushes the plunger 325, the lock mechanism is released. Thereafter, when the operator removes his / her finger from the plunger 325, the force pushing the plunger 325 is released, so that the plunger 325 is retracted in the proximal direction by the elastic energy stored in the second spring 231. Subsequently, due to the elastic energy stored in the first spring 230, the plunger 325 is further retracted in the proximal direction together with the syringe 224, and returns to the initial state. By this movement, the engagement pin 229 moves backward from the position B (see FIG. 20) to the position C (see FIG. 20) in the cam groove 228.
- the plunger 325 whose tip is accommodated in the syringe 224 is also retracted, so that the inner needle 11 connected to the distal end of the plunger 325 is also retracted, and the distal end of the inner needle 11 is the outer needle 10. Housed again inside.
- FIG. 22 and 23 are perspective views of the distal end portion of the puncture needle according to the fourth embodiment.
- FIG. 24 is a cross-sectional view of the distal end portion of the puncture needle 402 shown in FIG. 22 cut along the central axis in the longitudinal direction of the puncture needle 402.
- FIG. 25 is a cross-sectional view of the distal end portion of the puncture needle 402 shown in FIG. 23 taken along the central axis in the longitudinal direction of the puncture needle 402.
- the puncture needle 402 has a distal end portion 441 in which an opening 13 is provided on a side surface and a cooperation mechanism is provided inside, and a rotation about an axis relative to the distal end portion 441.
- An outer needle 410 having a movable proximal end 442 is provided.
- the cooperation mechanism rotates only the distal end portion 441 of the outer needle 410, and does not rotate the proximal end portion 442.
- the inner needle 411 is inserted into the first lumen 412 of the outer needle 410 so as to be able to advance and retract.
- the inner needle 411 moves at least from the first state (see FIGS. 22 and 24) in which the distal end portion of the inner needle 411 is accommodated in the outer needle 410 by the forward and backward movement of the inner needle 411 and from the opening 13 of the outer needle 410.
- a transition is made between the second state (see FIGS. 23 and 25) in which a part of the tip of the inner needle 411 protrudes.
- the proximal end of the inner needle 411 extends the first lumen 412 of the proximal end portion 442 of the outer needle 410.
- the proximal end of the inner needle 411 is connected to the tube 4 communicating with the internal space of the syringe 5 as in the first embodiment.
- An engagement mechanism is provided on the outer surface of the inner needle 411 and the inner surface of the first lumen 412 of the outer needle 410 so that they can be engaged with each other.
- the engagement pin 443 is provided on the outer surface of the inner needle 411, and the engagement pin 443 can be engaged with the inner surface of the first lumen 412.
- a member 444 is provided. As shown in FIGS. 24 and 25, the engagement pin 443 and the engaged member 444 are when the inner needle 11 is in the first state in which the distal end portion of the inner needle 11 is accommodated in the outer needle 410. It is in a positional relationship that only engages.
- a stopper 445 that can prevent the engagement pin 443 from moving forward is provided on the inner surface of the outer needle 410 and on the distal end side of the engaged member 444, and the distal end of the inner needle 411 protrudes excessively. Is preventing.
- FIG. 26 is a schematic diagram for explaining the shape of the engaged member 444 shown in FIGS. 24 and 25.
- FIG. 26 shows a state where the engaged member 444 is rotated 90 ° counterclockwise from the state shown in FIGS. 24 and 25 for the sake of explanation.
- the engaged member 444 has a shape in which the side surface of the cylinder is notched into a mountain shape.
- the notch shape includes a surface parallel to the axial direction of the outer needle 410, a base end of a surface parallel to the axial direction of the outer needle 410, and a surface parallel to the axial direction of another outer needle 410 adjacent to this surface. It is formed by the inclined surface which connects a front-end
- Embodiment 4 the operator advances the inner needle 411 relative to the outer needle 410.
- the engagement pin 443 of the inner needle 411 is also advanced, so that the engagement between the engagement pin 443 of the inner needle 411 and the engaged member 444 of the outer needle 410 is released.
- the operator further advances the inner needle 411 until the engagement pin 443 stops at the stopper 445, so that the tip of the inner needle 411 protrudes from the opening 13 of the outer needle 410 (FIGS. 23 and 25).
- the medicine is supplied to the second lumen 14 of the inner needle 411 for dosing. Even if the operator rotates the inner needle 411 in this state, the outer needle 410 does not rotate because the engaged member 444 is not engaged with the engaging pin 443 of the inner needle 411.
- the operator retracts the inner needle 411 with respect to the outer needle 410, and stores the tip of the inner needle 411 in the first lumen 412 of the outer needle 410 (see FIGS. 22 and 24). ). After the operator retracts the inner needle 411 until the engaging pin 443 of the inner needle 411 contacts the engaged member 444, the operator rotates the inner needle 411 in a predetermined direction.
- the rotational movement is engaged by the engagement pin 443 that hits the surface parallel to the axial direction of the engaged member 444.
- the outer needle 410 is also rotated in the direction of the arrow Y42, and the direction in which the opening 13 is directed changes.
- the rotation movement of the inner needle 411 causes the engagement pin 443 to move in the axial direction of the engaged member 444.
- the outer pin 410 is not transmitted from the engaging pin 443 to the engaged member 444, and the outer needle 410 does not rotate. Therefore, the engagement pin 443 and the engaged member 444 function as an engagement mechanism that causes the outer needle 410 to rotate by the rotation of the inner needle 411 when the inner needle 411 is in the first state. .
- the inner needle 11 protrudes from the opening 13 of the outer needle 410, and the inner needle. Since the discharge of the medicine from the tip of 411, the storage of the inner needle 411 into the opening 13 of the outer needle 410, and the rotation cycle around the axis of the outer needle 410 can be repeated, a plurality of the internal needles 411 Multipoint administration to a location can be easily realized.
- the angled surface of the outer needle 410 that is parallel to the axial direction of the engaged member 444 shown in FIG.
- An engaged member 444a (see FIG. 27) having a further acute apex angle may be used.
- the engagement pin 443 may be elastic so that it can get over the angled apex portion of the engaged member 444a when the inner needle 411 moves forward.
- the engaged member of the outer needle 410 is engaged with the retracted inner needle 411 so that when the inner needle 411 is rotated in one direction, the rotation movement is transmitted by the engagement pin 443. Since it is sufficient that the angle at which the coupling pin 443 is caught is on the proximal end side, it is not always necessary to form the mountain shape like the engaged member 444b shown in FIG.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A medicine administration apparatus (1) is provided with the following: an external needle (10) having an internal first rumen (12) and an aperture (13) on a side surface of the tip, where the aperture (13) communicates with the first rumen (12); and an internal needle (11) that has an internal second rumen (14) and that is inserted so that the tip of the internal needle is capable of forward and backward movement in the first rumen (12) of the external needle (10). By means of the forward and backward movement, the internal needle (11) transitions between a first position, wherein the tip thereof is housed in the first rumen (12) of the external needle (10) and a second position, wherein at least part of the tip of the internal needle protrudes from the aperture (13) of the external needle (10).
Description
この発明は、生体組織内に穿刺される穿刺針、生体組織に薬剤を投与する薬剤投与装置およびシリンジポンプに関するものである。
The present invention relates to a puncture needle that is punctured into a living tissue, a drug administration device that administers a drug to the living tissue, and a syringe pump.
従来、人間を含む哺乳動物の生体組織内に穿刺されて、薬剤投与目標の生体組織に薬剤を投与する穿刺針が知られている(たとえば、特許文献1参照)。このような穿刺針を用いた薬剤投与方法として、静脈内の血流に薬剤を投与する方法のほか、対象とする部位への薬剤送達を確実化するために、腫瘍に抗癌剤などの薬剤を直接投与する方法がある。
Conventionally, there has been known a puncture needle that is punctured into a living tissue of a mammal including human beings and administers a drug to the target tissue of the drug administration (for example, see Patent Document 1). In addition to the method of administering the drug to the blood flow in the vein as a method of drug administration using such a puncture needle, in order to ensure drug delivery to the target site, a drug such as an anticancer drug is directly applied to the tumor. There is a method of administration.
例えば、すい臓癌の治療方法としてEUS-FNI(Edoscopic Ultrasonography guided Fine needle Injection:超音波内視鏡下薬液注入)が注目されており、超音波内視鏡によるエコー画像を用いて、腫瘍の位置を確認した上で、針を腫瘍に向けて穿刺し、薬剤を注入する治療法が研究されている。
For example, EUS-FNI (Edoscopic Ultrasonography guided Needle Injection: ultrasound endoscopic drug solution injection) has been attracting attention as a treatment method for pancreatic cancer, and the position of the tumor is determined using echo images from an ultrasound endoscope. After confirmation, a treatment method in which a needle is punctured toward a tumor and a drug is injected has been studied.
腫瘍に直接薬剤を投与する場合、特に悪性度の高い硬い腫瘍への注入性の悪さが問題となる。実際に本願発明者らが実施した実験によれば、悪性度の高いヒト膵臓がん株細胞へのボーラス投与を行なった場合、1箇所あたり100マイクロリットル程度の注入が必要であるにもかかわらず、1箇所あたり10~20マイクロリットル程度の抗がん剤注入が限度であり、それを超える量の薬液を注入した場合、注入口からの逆流が発生する場合もあった。
When administering a drug directly to a tumor, poor injectability into a hard tumor with high malignancy is a problem. According to experiments actually conducted by the inventors of the present application, when bolus administration is performed on human pancreatic cancer cell lines with high malignancy, although injection of about 100 microliters per site is necessary The injection of an anticancer agent of about 10 to 20 microliters per site is the limit, and when a drug solution exceeding that amount is injected, backflow from the injection port may occur.
そこで、腫瘍から逆流することなく相当量の抗がん剤を投与するために、微量の抗がん剤を絶えず持続して注入し続ける持続注入を採用することが考えられる。しかしながら、この場合には、体内への穿刺針の留置やポンプの携帯などの大きな負担を患者に与えてしまうという問題があった。
Therefore, in order to administer a considerable amount of anticancer agent without flowing back from the tumor, it is conceivable to adopt continuous injection that continuously injects a trace amount of anticancer agent. However, in this case, there is a problem that the patient is burdened with a large burden such as indwelling the puncture needle in the body and carrying the pump.
また、所定量の薬剤を注入するために注入回数を多くする場合、EUS-FNIでは、所定量を腫瘍に注入するために腫瘍への針の穿刺を複数回繰り返すこととなる。しかしながら、この場合には、超音波画像下で何度も正確に腫瘍を穿刺する必要があるため、術者の負担になってしまうという問題があった。
In addition, when the number of injections is increased in order to inject a predetermined amount of medicine, in EUS-FNI, the needle is punctured a plurality of times to inject a predetermined amount into the tumor. However, in this case, since it is necessary to puncture the tumor accurately and repeatedly under the ultrasonic image, there is a problem that it is a burden on the operator.
この発明は、上記に鑑みてなされたものであって、所定量の薬剤の容易な多点投与を実現できる穿刺針、薬剤投与装置およびシリンジポンプを提供することを目的とする。
The present invention has been made in view of the above, and an object thereof is to provide a puncture needle, a drug administration device, and a syringe pump that can realize easy multipoint administration of a predetermined amount of drug.
上述した課題を解決し、目的を達成するために、この発明にかかる穿刺針は、生体組織に穿刺される穿刺針であって、内部に第1のルーメンを有し、先端側の側面に前記第1のルーメンと連通する開口が設けられた外針と、内部に第2のルーメンを有するとともに、少なくとも先端部が前記外針の前記第1のルーメンに進退運動可能に挿通された内針と、を備え、前記内針は、前記進退運動によって、前記外針の前記第1のルーメンに前記先端部が収容される第1の状態と、前記外針の前記開口から少なくとも前記先端部の一部が突出する第2の状態との間を遷移することを特徴とする。
In order to solve the above-described problems and achieve the object, a puncture needle according to the present invention is a puncture needle that is punctured into a living tissue, has a first lumen inside, and is provided on the side surface on the distal end side. An outer needle provided with an opening communicating with the first lumen; an inner needle having a second lumen inside; and at least a distal end portion inserted through the first lumen of the outer needle so as to be capable of moving forward and backward. The inner needle has a first state in which the tip portion is accommodated in the first lumen of the outer needle by the forward and backward movement, and at least one of the tip portions from the opening of the outer needle. A transition is made between the second state in which the portion protrudes.
また、この発明にかかる穿刺針は、上記の発明において、前記内針の先端は、前記外針の前記開口から突出したときに外側となる角が鋭角を成すことを特徴とする。
The puncture needle according to the present invention is characterized in that, in the above-mentioned invention, the tip of the inner needle forms an acute angle when it protrudes from the opening of the outer needle.
また、この発明にかかる穿刺針は、上記の発明において、前記内針は、前記外針の前記第1のルーメンに対して前進することによって、当該内針の前記先端部の一部が突出し、前記外針は、前記内針の先端を前記第1のルーメンから前記開口に誘導するガイド面を、前記第1のルーメンに有することを特徴とする。
Further, in the puncture needle according to the present invention, in the above invention, when the inner needle moves forward with respect to the first lumen of the outer needle, a part of the tip portion of the inner needle protrudes, The outer needle has a guide surface on the first lumen for guiding the tip of the inner needle from the first lumen to the opening.
また、この発明にかかる穿刺針は、上記の発明において、前記開口は、前記外針の側面に複数設けられることを特徴とする。
The puncture needle according to the present invention is characterized in that, in the above invention, a plurality of the openings are provided on a side surface of the outer needle.
また、この発明にかかる穿刺針は、上記の発明において、前記複数の開口は、前記外針の長手方向における位置がそれぞれ異なることを特徴とする。
Further, the puncture needle according to the present invention is characterized in that, in the above-mentioned invention, the plurality of openings have different positions in the longitudinal direction of the outer needle.
また、この発明にかかる穿刺針は、上記の発明において、前記内針は、前記複数の開口に対応して先端が分岐することを特徴とする。
Further, the puncture needle according to the present invention is characterized in that, in the above invention, the inner needle has a tip branched corresponding to the plurality of openings.
また、この発明にかかる穿刺針は、上記の発明において、前記外針は、前記内針の先端を前記第1のルーメンから前記開口に誘導するガイド面を、前記第1のルーメンに前記開口ごとに有し、各ガイド面は、それぞれ異なる角度の傾斜を有することを特徴とする。
In the puncture needle according to the present invention, in the above invention, the outer needle has a guide surface for guiding the tip of the inner needle from the first lumen to the opening, and the first lumen has the opening. Each guide surface has an inclination of a different angle.
また、この発明にかかる穿刺針は、上記の発明において、前記外針の前記開口の軸方向を基端側に延伸する延長線上には、マーカが付されていることを特徴とする。
The puncture needle according to the present invention is characterized in that, in the above-mentioned invention, a marker is attached on an extension line extending in the axial direction of the opening of the outer needle toward the proximal end.
また、この発明にかかる穿刺針は、上記の発明において、前記内針が前記第1の状態にあるときに、前記内針の運動と、前記外針の長手軸中心の回動運動とを連携させる連携機構をさらに備えたことを特徴とする。
In the puncture needle according to the present invention, in the above invention, when the inner needle is in the first state, the movement of the inner needle and the rotational movement about the longitudinal axis of the outer needle are linked. It is characterized by further comprising a cooperation mechanism to be made.
また、この発明にかかる穿刺針は、上記の発明において、前記連携機構は、前記内針が前記第1の状態にあるときに、前記内針の進退運動によって前記外針の回転運動を生じさせる係合機構を含むことを特徴とする。
Further, in the puncture needle according to the present invention, in the above invention, the cooperation mechanism causes the outer needle to rotate by the advance and retreat of the inner needle when the inner needle is in the first state. An engagement mechanism is included.
また、この発明にかかる穿刺針は、上記の発明において、前記係合機構は、係合ピンとカム溝を有し、前記係合ピンが前記カム溝に係合するものであることを特徴とする。
The puncture needle according to the present invention is characterized in that, in the above invention, the engagement mechanism includes an engagement pin and a cam groove, and the engagement pin engages with the cam groove. .
また、この発明にかかる穿刺針は、上記の発明において、前記カム溝は、軸方向に伸長する複数の直線溝と、各直線溝の基端と、各直線溝と隣り合う一方の前記直線溝の先端とをそれぞれ接続する溝であって前記複数の直線溝間を斜めに結ぶ複数の傾斜溝とによって形成されることを特徴とする。
Further, in the puncture needle according to the present invention, in the above invention, the cam groove includes a plurality of linear grooves extending in an axial direction, a base end of each linear groove, and one linear groove adjacent to each linear groove. It is characterized by being formed by a plurality of inclined grooves that respectively connect the front ends of the plurality of slanted grooves and that obliquely connect the plurality of linear grooves.
また、この発明にかかる穿刺針は、上記の発明において、前記係合ピンは、前記外針に接続するとともに前記内針の前進運動にしたがって前進する接続部材に設けられており、前記接続部材の前進により前記カム溝の前記傾斜溝を進行することによって前記外針を回転させることを特徴とする。
Further, in the puncture needle according to the present invention, in the above invention, the engagement pin is provided on a connection member that is connected to the outer needle and that moves forward according to the forward movement of the inner needle. The outer needle is rotated by advancing the inclined groove of the cam groove by advancing.
また、この発明にかかる穿刺針は、上記の発明において、前記外針を一定の方向に回動するように付勢する付勢機構をさらに有することを特徴とする。
Further, the puncture needle according to the present invention is characterized in that, in the above-described invention, the puncture needle further includes a biasing mechanism that biases the outer needle to rotate in a certain direction.
また、この発明にかかる穿刺針は、上記の発明において、前記連携機構は、前記内針が前記第1の状態にあるときに、前記内針の回転運動によって前記外針の回転運動を生じさせる係合機構を有することを特徴とする。
In the puncture needle according to the present invention, in the above invention, the cooperation mechanism causes the outer needle to rotate by the rotation of the inner needle when the inner needle is in the first state. It has an engagement mechanism.
また、この発明にかかる穿刺針は、上記の発明において、前記係合機構は、前記内針の外側面および前記外針の第1のルーメンの内側面のいずれか一方に設けられた係合ピンと、前記内針の外側面および外針の第1のルーメンの内側面の他方に設けられた被係合部材とを備え、前記係合ピンと前記被係合部材とは、前記内針が前記第1の区間にあるときに係合する位置関係を有し、前記係合ピンと前記被係合部材とが係合することによって、前記内針の回転運動が前記外針に伝達されて前記外針に回転運動が生じることを特徴とする。
In the puncture needle according to the present invention, in the above invention, the engagement mechanism may include an engagement pin provided on one of the outer surface of the inner needle and the inner surface of the first lumen of the outer needle. And an engaged member provided on the other of the outer surface of the inner needle and the inner surface of the first lumen of the outer needle, and the engaging pin and the engaged member are configured such that the inner needle is the first member. The outer needle has a positional relationship to be engaged when it is in the section 1, and the rotational movement of the inner needle is transmitted to the outer needle by the engagement of the engagement pin and the engaged member. Rotational motion occurs in
また、この発明にかかる穿刺針は、上記の発明において、前記外針は、基端部分と、前記開口及び前記連携機構が位置するとともに前記基端部分に対して当該外針の軸周りに回動自在である先端部分とを備え、前記外針の前記先端部分は、前記連携機構によって前記基端部分に対して回動運動するように構成されていることを特徴とする。
The puncture needle according to the present invention is the puncture needle according to the above invention, wherein the outer needle is positioned around the axis of the outer needle with respect to the proximal end portion while the proximal end portion, the opening and the cooperation mechanism are located. A distal end portion that is movable, and the distal end portion of the outer needle is configured to rotate with respect to the proximal end portion by the cooperation mechanism.
また、この発明にかかる穿刺針は、上記の発明において、前記内針は、基端においてシリンジポンプと接続しており、前記シリンジポンプは、外面に雄ネジが形成されたプランジャと、内面に雌ネジが形成されたシリンジとを有することを特徴とする。
In the puncture needle according to the present invention, in the above invention, the inner needle is connected to a syringe pump at a proximal end, and the syringe pump includes a plunger having an external thread formed on an outer surface and a female on an inner surface. And a syringe having a screw formed thereon.
また、この発明にかかる薬剤投与装置は、生体組織に穿刺される穿刺針と、前記穿刺針に薬剤を送出する薬剤送出ユニットを有する薬剤投与装置であって、前記穿刺針は、内部に第1のルーメンを有し、先端側の側面に前記第1のルーメンと連通する開口が設けられた外針と、内部に第2のルーメンを有するとともに少なくとも先端部が前記外針の前記第1のルーメンに進退運動可能に挿通された内針とを備え、前記内針は、前記進退運動によって、前記外針の前記第1のルーメンに前記先端部が収容される第1の状態と、前記外針の前記開口から少なくとも前記先端部の一部が突出する第2の状態との間を遷移し、前記薬剤送出ユニットは、前記薬剤を保持する保持部と、前記保持部に保持される前記薬剤を前記内針の前記第2のルーメンに送出する送出ポンプと、少なくとも前記内針が前記第2の状態であり、かつ、前記内針が前記外針に対して後退しているときに前記送出ポンプに薬剤送出のための圧力を印加させる制御部と、を備えたことを特徴とする。
The drug administration device according to the present invention is a drug administration device having a puncture needle that is punctured into a living tissue and a drug delivery unit that delivers the drug to the puncture needle, and the puncture needle has a first inside. An outer needle having an opening communicating with the first lumen on the side surface on the distal end side, a second lumen inside, and at least a distal end portion of the first lumen of the outer needle. A first state in which the tip portion is accommodated in the first lumen of the outer needle by the forward / backward movement, and the outer needle. Transition from a second state in which at least a part of the distal end portion protrudes from the opening, and the medicine delivery unit includes a holding part for holding the medicine and the medicine held in the holding part. The second lumen of the inner needle And a pressure for delivering a drug to the delivery pump when at least the inner needle is in the second state and the inner needle is retracted relative to the outer needle. And a control unit for controlling the operation.
また、この発明にかかるシリンジポンプは、外面に雄ネジが形成されたプランジャと、内面に雌ネジが形成されたシリンジと、を備えたことを特徴とする。
Further, the syringe pump according to the present invention is characterized by comprising a plunger having a male screw formed on the outer surface and a syringe having a female screw formed on the inner surface.
また、この発明にかかるシリンジポンプは、上記の発明において、前記プランジャに形成された前記雄ネジと、前記シリンジの内面に形成された前記雌ネジとの嵌合は、解除可能に構成されていることを特徴とする。
Further, in the syringe pump according to the present invention, in the above invention, the fitting between the male screw formed on the plunger and the female screw formed on the inner surface of the syringe is configured to be releasable. It is characterized by that.
この発明にかかる穿刺針および薬剤投与装置によれば、穿刺針は、内部に第1のルーメンを有し、先端側の側面に第1のルーメンと連通する開口が設けられた外針と、内部に第2のルーメンを有するとともに、少なくとも先端部が外針の第1のルーメンに進退運動可能に挿通された内針と、を備え、内針は、進退運動によって、外針の第1のルーメンに先端部が収容される第1の状態と、外針の開口から少なくとも先端部の一部が突出する第2の状態との間を遷移できるため、内針が外針の開口より突出した状態で内針から薬剤を吐出させる操作と、内針を開口内に収納する操作、そして外針を回転させる操作を繰り返すことにより、薬剤の多点投与を容易に行うことができる。
According to the puncture needle and the drug administration device according to the present invention, the puncture needle has a first lumen inside, an outer needle provided with an opening communicating with the first lumen on the side surface on the distal end side, And an inner needle having at least a distal end portion inserted through the first lumen of the outer needle so as to be capable of moving forward and backward. The inner needle is moved forward and backward to move the first lumen of the outer needle. The inner needle protrudes from the opening of the outer needle because the transition between the first state in which the distal end is accommodated in the second state and the second state in which at least a part of the distal end protrudes from the opening of the outer needle can be made. By repeating the operation of discharging the medicine from the inner needle, the operation of housing the inner needle in the opening, and the operation of rotating the outer needle, it is possible to easily carry out multipoint administration of the medicine.
また、この発明にかかるシリンジポンプによれば、外面に雄ネジが形成されたプランジャと、内面に雌ネジが形成されたシリンジと、を備えるため、プランジャの回転数を制御することによって、微量の薬剤等であっても正確に吐出できる。
In addition, according to the syringe pump according to the present invention, since it includes the plunger with the external thread formed on the outer surface and the syringe with the internal thread formed on the inner surface, by controlling the rotation speed of the plunger, Even medicines can be discharged accurately.
以下、図面を参照して、この発明を実施するための形態として、人間を含む哺乳動物の生体組織に導入される穿刺針および生体組織に薬剤を投与する薬剤投与装置について説明する。なお、この実施の形態によりこの発明が限定されるものではない。また、図面の記載において、同一部分には同一の符号を付している。
Hereinafter, with reference to the drawings, as a mode for carrying out the present invention, a puncture needle introduced into a living tissue of a mammal including a human and a drug administration device for administering the drug to the living tissue will be described. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.
(実施の形態1)
図1は、本実施の形態1における薬剤投与装置による生体組織に対する薬剤投与を説明する図である。 (Embodiment 1)
FIG. 1 is a diagram for explaining drug administration to a living tissue by the drug administration device according to the first embodiment.
図1は、本実施の形態1における薬剤投与装置による生体組織に対する薬剤投与を説明する図である。 (Embodiment 1)
FIG. 1 is a diagram for explaining drug administration to a living tissue by the drug administration device according to the first embodiment.
図1に示すように、実施の形態1における薬剤投与装置1は、先端に設けられ生体組織に穿刺される穿刺針2、穿刺針2の基端側に設けられた把持部3、穿刺針2に薬剤を導くチューブ4、および、内部に保持する薬剤をチューブ4に送出するシリンジ5を有する。穿刺針2は、たとえば、ステンレスやチタンなどによって形成される。チューブ4は、例えばシリコン、ポリエチレン、ポリウレタン等によって形成される。
As shown in FIG. 1, a drug administration device 1 according to Embodiment 1 includes a puncture needle 2 provided at a distal end and punctured into a living tissue, a gripping portion 3 provided on a proximal end side of the puncture needle 2, and a puncture needle 2. And a syringe 5 for delivering the drug held inside to the tube 4. The puncture needle 2 is made of, for example, stainless steel or titanium. The tube 4 is made of, for example, silicon, polyethylene, polyurethane, or the like.
図1に示す例では、穿刺針2は、体表6の奥に位置する臓器7に穿刺されている。操作者は、プランジャ8をシリンジ5に対して前進させることで、シリンジ5内部に蓄えられた薬剤を、チューブ4および穿刺針2を介して、臓器内に投与することができる。
In the example shown in FIG. 1, the puncture needle 2 is punctured into an organ 7 located at the back of the body surface 6. The operator can administer the medicine stored in the syringe 5 into the organ through the tube 4 and the puncture needle 2 by moving the plunger 8 forward with respect to the syringe 5.
図2~図5を参照して、穿刺針2の先端部の構成について説明する。図2および図3は、図1に示す穿刺針2の先端部の斜視図である。図4は、図2に示す穿刺針2の先端部分を、該穿刺針2の長手方向の中心軸に沿って切断した断面図である。図5は、図3に示す穿刺針2の先端部分を、該穿刺針2の長手方向の中心軸に沿って切断した断面図である。図2~図5に示すように、穿刺針2は、外針10および内針11を備える。
The configuration of the distal end portion of the puncture needle 2 will be described with reference to FIGS. 2 and 3 are perspective views of the distal end portion of the puncture needle 2 shown in FIG. FIG. 4 is a cross-sectional view of the distal end portion of the puncture needle 2 shown in FIG. 2 cut along the central axis in the longitudinal direction of the puncture needle 2. FIG. 5 is a cross-sectional view of the tip portion of the puncture needle 2 shown in FIG. 3 cut along the central axis in the longitudinal direction of the puncture needle 2. As shown in FIGS. 2 to 5, the puncture needle 2 includes an outer needle 10 and an inner needle 11.
外針10は、内部に第1のルーメン12を有し、先端側の側面に、第1のルーメン12と連通する開口13が設けられるとともに、先端が尖った細長い形状を成す。外針10は、長手方向の中心軸との円直面で切断した場合、外側面が円形を形成する。
The outer needle 10 has a first lumen 12 inside, an opening 13 communicating with the first lumen 12 is provided on the side surface on the tip side, and has an elongated shape with a pointed tip. When the outer needle 10 is cut by facing a circle with the central axis in the longitudinal direction, the outer surface forms a circle.
内針11は、少なくとも先端部が、外針10の第1のルーメン12に進退運動可能に挿通される。内針11は、第1のルーメン12に対して、前進および後退のいずれの運動も可能である。
The inner needle 11 is inserted through the first lumen 12 of the outer needle 10 at least at the tip so as to be able to advance and retreat. The inner needle 11 can move forward and backward with respect to the first lumen 12.
内針11は、先端が開口した第2のルーメン14を内部に有する。内針11は、チューブ4に接続され、第2のルーメン14は、チューブ4の内部ルーメンと連通する。このチューブ4の内部ルーメンは、シリンジ5の内部空間と連通している。第2のルーメン14は、シリンジ5内に保持される薬剤や生理食塩水等が搬送される通路として機能し、内針11先端の開口11aから薬剤や生理食塩水等が吐出される。
The inner needle 11 has a second lumen 14 with an open end. The inner needle 11 is connected to the tube 4, and the second lumen 14 communicates with the inner lumen of the tube 4. The internal lumen of the tube 4 communicates with the internal space of the syringe 5. The second lumen 14 functions as a passage through which the medicine, physiological saline and the like held in the syringe 5 are conveyed, and the medicine, physiological saline and the like are discharged from the opening 11a at the tip of the inner needle 11.
外針10と把持部3(図1参照)とは、たとえば、一体的に形成されており、操作者は、把持部3を把持して把持部3を操作することによって、外針10を生体組織に穿刺することや、外針10を軸周りに回動させることが可能である。
The outer needle 10 and the gripping part 3 (see FIG. 1) are formed integrally, for example, and the operator grips the gripping part 3 and operates the gripping part 3 to move the outer needle 10 to the living body. It is possible to puncture the tissue and rotate the outer needle 10 around the axis.
ここで、内針11は、内針11の進退運動によって、外針10の第1のルーメン12に内針11の先端部が収容される第1の状態(図2および図4参照)と、外針10の開口13から少なくとも内針11の先端部の一部が突出する第2の状態(図3および図5参照)との間を遷移する。
Here, the inner needle 11 is in a first state in which the distal end portion of the inner needle 11 is accommodated in the first lumen 12 of the outer needle 10 by the forward and backward movement of the inner needle 11 (see FIGS. 2 and 4), A transition is made between the second state (see FIGS. 3 and 5) in which at least a part of the tip of the inner needle 11 protrudes from the opening 13 of the outer needle 10.
内針11は、第1のルーメン12において前進することによって、外針10の第1のルーメン12に内針11の先端部が収容される第1の状態から、外針10の開口13から内針11の先端部の一部が突出する第2の状態に遷移する。
The inner needle 11 advances from the first lumen 12 to move the inner needle 11 from the opening 13 of the outer needle 10 from the first state where the distal end portion of the inner needle 11 is accommodated in the first lumen 12 of the outer needle 10. It changes to the 2nd state from which a part of tip part of needle 11 protrudes.
外針10は、内針11の先端を第1のルーメン12から開口13に誘導するガイド面10aを、第1のルーメン12に有する。このガイド面10aは、図4および図5に示すように、開口13の先端側端部から基端側に向かって傾斜する傾斜面である。内針11の先端が最も長く突出した場合に、突出した内針11の先端位置が薬剤を投与させたい位置に達するように、内針11の突出長さと薬剤を投与させたい位置とをもとにガイド面10aの傾斜角度が設定される。
The outer needle 10 has a guide surface 10 a for guiding the tip of the inner needle 11 from the first lumen 12 to the opening 13 in the first lumen 12. As shown in FIGS. 4 and 5, the guide surface 10 a is an inclined surface that is inclined from the distal end side end portion of the opening 13 toward the proximal end side. Based on the protruding length of the inner needle 11 and the position where the drug is to be administered so that the tip position of the protruding inner needle 11 reaches the position where the drug is to be administered when the distal end of the inner needle 11 is projected the longest. The inclination angle of the guide surface 10a is set.
内針11の先端は、外針10の前記開口13から突出したときに外側となる角が鋭角を成す。これによって、開口13から突出した内針11先端が、外針10周囲の生体組織を切り開きながら生体組織内に入りやすくなるため、内針11が外針10の外側に向かって開口から広がるように突出することができる。
When the tip of the inner needle 11 protrudes from the opening 13 of the outer needle 10, the outer angle forms an acute angle. As a result, the tip of the inner needle 11 protruding from the opening 13 can easily enter the living tissue while opening the living tissue around the outer needle 10, so that the inner needle 11 extends from the opening toward the outside of the outer needle 10. Can protrude.
図6に示すように、外針10の第1のルーメン12には、ストッパ15が前後に所定距離(位置Pおよび位置Qの間)だけ離間して設けられている。内針11の外部側面には、突起16が設けられ、前後のストッパ15の間に位置している。ストッパ15に内針11の突起16が当たることによって、第1のルーメン12において内針11が移動できる範囲は限定される。したがって、穿刺針2においては、外針10から内針11が過度に突出することや、内針11が誤って引き抜かれることがない。
As shown in FIG. 6, a stopper 15 is provided on the first lumen 12 of the outer needle 10 so as to be separated by a predetermined distance (between the position P and the position Q). A protrusion 16 is provided on the outer side surface of the inner needle 11 and is positioned between the front and rear stoppers 15. The range in which the inner needle 11 can move in the first lumen 12 by the contact of the protrusion 16 of the inner needle 11 with the stopper 15 is limited. Therefore, in the puncture needle 2, the inner needle 11 does not protrude excessively from the outer needle 10 and the inner needle 11 is not pulled out by mistake.
次に、図1に示すシリンジ5とプランジャ8について説明する。図7は、図1に示すシリンジ5の要部およびプランジャ8を示す斜視図である。図7に示すように、プランジャ8の外面のうちシリンジ5内に挿入される領域には雄ネジ8aが形成されている。一方、シリンジ5のプランジャ8挿入部の内面には、プランジャ8の雄ネジ8aに嵌まり合う雌ネジ5aが形成される。
Next, the syringe 5 and the plunger 8 shown in FIG. 1 will be described. FIG. 7 is a perspective view showing the main part of the syringe 5 and the plunger 8 shown in FIG. As shown in FIG. 7, a male screw 8 a is formed in a region inserted into the syringe 5 on the outer surface of the plunger 8. On the other hand, on the inner surface of the plunger 8 insertion portion of the syringe 5, a female screw 5 a that fits into the male screw 8 a of the plunger 8 is formed.
雄ネジ8aおよび雌ネジ5aが嵌まり合うようにした状態で、プランジャ8を、シリンジ5先端側に前進するようにシリンジ5に対して回転させることによって、薬剤等をシリンジ5先端から吐出することができる。たとえば、プランジャ8をシリンジ5に対して1回転することによって、シリンジ5先端から12.5マイクロリットルの薬剤等を吐出できる。したがって、このシリンジ5およびプランジャ8によれば、プランジャ8の回転数を制御することによって、微量の薬剤等を正確に吐出することができる。なお、シリンジ5の基端およびプランジャ8の基端部には、プランジャ8のシリンジ5に対する回転量が判別できるように、マーカ5b,8bが設けられている。
With the male screw 8a and the female screw 5a fitted together, the plunger 8 is rotated with respect to the syringe 5 so as to advance toward the distal end side of the syringe 5, thereby discharging the medicine or the like from the distal end of the syringe 5. Can do. For example, by rotating the plunger 8 once with respect to the syringe 5, 12.5 microliters of medicine or the like can be discharged from the tip of the syringe 5. Therefore, according to the syringe 5 and the plunger 8, by controlling the number of rotations of the plunger 8, it is possible to accurately discharge a small amount of medicine or the like. Markers 5b and 8b are provided at the proximal end of the syringe 5 and the proximal end of the plunger 8 so that the amount of rotation of the plunger 8 relative to the syringe 5 can be determined.
また、プランジャ8とシリンジ5とは雄ネジ8aおよび雌ネジ5aで嵌まり合うため、プランジャ8を押す力がなくなった場合であっても、プランジャ8は、シリンジ5に対してそのままの位置を保ち、外側に押し出されることはない。したがって、操作者は、薬剤等の吐出中であってもプランジャ8から手を離すことができる。
Further, since the plunger 8 and the syringe 5 are fitted with each other with the male screw 8a and the female screw 5a, the plunger 8 maintains the position as it is with respect to the syringe 5 even when the force for pushing the plunger 8 is lost. , Never pushed out. Therefore, the operator can release his / her hand from the plunger 8 even while the medicine is being discharged.
次に、図8を参照して、図1に示す薬剤投与装置1による薬剤投与処理の一例について説明する。図8は、図1に示す薬剤投与装置1を用いた薬剤投与処理の処理手順を示すフローチャートである。
Next, an example of a drug administration process performed by the drug administration device 1 shown in FIG. 1 will be described with reference to FIG. FIG. 8 is a flowchart showing a procedure of a drug administration process using the drug administration device 1 shown in FIG.
図8に示すように、内針11の先端部を外針10内部の第1のルーメン12に収納した(ステップS1)第1の状態(図2および図4参照)としてから、外針10を生体組織に穿刺して外針10の先端を薬剤投与対象の臓器7の内部に導入する(ステップS2)。
As shown in FIG. 8, after the distal end portion of the inner needle 11 is housed in the first lumen 12 inside the outer needle 10 (step S1), the outer needle 10 is moved to the first state (see FIGS. 2 and 4). The living tissue is punctured and the tip of the outer needle 10 is introduced into the organ 7 to be administered with the drug (step S2).
外針10が生体組織に導入された状態において、操作者は、チューブ4を先端側に向かって押すことにより、内針11を外針10に対して前進させることによって、内針11の先端を外針10の開口13から突出させる(ステップS3)第2の状態(図3および図5参照)とする。この内針11先端の突出動作によって、内針11先端が広がる方向に位置する生体組織が内針11先端によって切り開かれ、切り込みができる。
In a state where the outer needle 10 is introduced into the living tissue, the operator pushes the tube 4 toward the distal end side to advance the inner needle 11 relative to the outer needle 10, thereby moving the distal end of the inner needle 11. Let it protrude from the opening 13 of the outer needle 10 (step S3), and assume a second state (see FIGS. 3 and 5). By the protruding operation of the tip of the inner needle 11, the living tissue located in the direction in which the tip of the inner needle 11 spreads is cut open by the tip of the inner needle 11, and can be cut.
操作者は、薬剤等の吐出量に対応する回転量分、プランジャ8を、シリンジ5先端側に前進するようにシリンジ5に対して回転させることによって、所定量の薬剤等をシリンジ5からチューブ4に送出し、内針11先端の開口11aから薬剤等を吐出させる(ステップS4)。吐出された薬剤は、内針11先端によって切り開かれた切り込みに浸潤してゆく。
The operator rotates the plunger 8 with respect to the syringe 5 so as to advance toward the distal end side of the syringe 5 by a rotation amount corresponding to the discharge amount of the medicine, etc. The medicine and the like are discharged from the opening 11a at the tip of the inner needle 11 (step S4). The discharged medicine infiltrates into the incision opened by the tip of the inner needle 11.
続いて、生体組織に外針10を導入した状態において、操作者はチューブ4を基端側に引いて、内針11を外針10に対して後退させ、内針11の先端を外針10の開口13の内部に収納して(ステップS5)、内針11を第1の状態とする。
Subsequently, in a state in which the outer needle 10 is introduced into the living tissue, the operator pulls the tube 4 toward the proximal end, retracts the inner needle 11 with respect to the outer needle 10, and moves the distal end of the inner needle 11 to the outer needle 10. In the opening 13 (step S5), and the inner needle 11 is set to the first state.
この状態で、操作者は、薬剤等の吐出が予定した回数に達したかを判断する(ステップS6)。操作者は、薬剤等の吐出が予定した回数に達していないと判断した場合(ステップS6:No)、把持部3を持って外針10を、長手軸を中心に所定の角度だけ回動させる(ステップS7)。例えば、予定の回数として6回が決まっていれば、操作者は、1回の回動において、60°程度、外針10を回動させる。図9に示すように、開口13が外針10の周方向のどの方向を現に向いているかが判別できるように、体外に位置する把持部3の側面であって、外針10の開口13の軸方向の延長線上には、マーカ3aが付されている。もちろん図9に示すマーカ3aに限らず、外針10の開口13の軸方向の延長線上に位置する把持部3の側面の一部を切り欠いて平らにして、開口13が外針10の周方向のどの方向を現に向いているかが判別できるようにしてもよい。
In this state, the operator determines whether or not the scheduled number of times of ejection of the medicine has been reached (step S6). When the operator determines that the scheduled number of ejections of the medicine or the like has not been reached (step S6: No), the operator holds the grip portion 3 and rotates the outer needle 10 by a predetermined angle around the longitudinal axis. (Step S7). For example, if the scheduled number of times is six, the operator rotates the outer needle 10 by about 60 ° in one rotation. As shown in FIG. 9, on the side surface of the grip portion 3 located outside the body, so as to be able to determine which direction in the circumferential direction of the outer needle 10 the opening 13 is facing, A marker 3a is attached on the extension line in the axial direction. Of course, the present invention is not limited to the marker 3 a shown in FIG. 9, and a part of the side surface of the grip portion 3 located on the extension line in the axial direction of the opening 13 of the outer needle 10 is cut out and flattened. It may be possible to determine which direction of the direction is currently facing.
その後、ステップS3に戻り、生体組織に外針10が穿刺された状態において、内針11の先端を外針10の開口13から突出させる(ステップS3)第2の状態とする。この内針11先端の突出動作によって、生体組織には前回とは別の角度の切込みが形成される。
Thereafter, the process returns to step S3, and the distal end of the inner needle 11 is protruded from the opening 13 of the outer needle 10 in a state where the outer needle 10 is punctured into the living tissue (step S3), and the second state is set. Due to the protruding operation of the tip of the inner needle 11, a cut with an angle different from the previous time is formed in the living tissue.
一方、ステップS6において、操作者は、薬剤等の吐出が予定した回数に達したと判断した場合(ステップS6:Yes)、外針10を抜き出すか、または、外針10を留置するか判断する(ステップS8)。操作者は、外針10を抜き出すと判断した場合(ステップS8:抜出)、外針10内部の第1のルーメン12に内針11が収納された状態で外針10を臓器7から抜き出す(ステップS9)。一方、外針10を留置すると判断した場合(ステップS8:留置)、そのまま外針10を臓器7内に留置する(ステップS10)。
On the other hand, in step S6, when it is determined that the number of times that the medicine or the like has been ejected has been reached (step S6: Yes), the operator determines whether to extract the outer needle 10 or leave the outer needle 10 in place. (Step S8). When the operator determines that the outer needle 10 is to be extracted (step S8: extraction), the outer needle 10 is extracted from the organ 7 with the inner needle 11 stored in the first lumen 12 inside the outer needle 10 ( Step S9). On the other hand, when it is determined that the outer needle 10 is to be placed (step S8: placement), the outer needle 10 is placed in the organ 7 as it is (step S10).
このように、実施の形態1においては、内針11が開口13より突出した状態で内針11から薬剤を吐出させる操作と、内針11を開口13内に収納して外針10を長手軸回りに回動させる操作とを予定の回数繰り返すことにより、多点投与を容易に行うことができる。
As described above, in the first embodiment, the medicine is ejected from the inner needle 11 with the inner needle 11 protruding from the opening 13, and the outer needle 10 is stored in the opening 13 while the inner needle 11 is housed in the opening 13. Multi-point administration can be easily performed by repeating the operation of rotating around a predetermined number of times.
また、本実施の形態1においては、臓器の固形がんなどの硬い生体組織に対して薬剤を吐出する場合、プランジャ8とシリンジ5とは雄ネジ8aおよび雌ネジ5aで嵌まり合うため、シリンジ5内の圧力が保たれることで、臓器7内における内針11の軌跡上に薬剤が吐出される。つまり、上述のように角度を変えて内針からの薬剤などの吐出を繰り返すことにより、図10に模式的に示すように、内針11が外針10より突出した状態では、略円錐形の底面の周L1に上に位置するため、図8に示すステップを前述の如く繰り返すことにより、周L1上の複数個所に薬剤が吐出され、薬剤投与対象領域に十分な量の薬剤を保持させることができる。
In the first embodiment, when a drug is ejected to a hard living tissue such as solid cancer of an organ, the plunger 8 and the syringe 5 are fitted with the male screw 8a and the female screw 5a. By maintaining the pressure in 5, the medicine is ejected on the locus of the inner needle 11 in the organ 7. That is, by repeating the discharge of the medicine or the like from the inner needle by changing the angle as described above, when the inner needle 11 protrudes from the outer needle 10, as shown schematically in FIG. Since the upper portion is located on the circumference L1 of the bottom surface, by repeating the steps shown in FIG. 8 as described above, the medicine is discharged to a plurality of locations on the circumference L1, and a sufficient amount of medicine is held in the medicine administration target region. Can do.
また、本実施の形態1においては、内針11よりも外径の大きな外針10は、穿刺針2の生体組織への導入時および穿刺針2の生体組織からの抜き出し時にのみ、生体組織に対して進退する。このため、実施の形態1によれば、外径の大きな外針10による臓器7に対する侵襲を少なくしながら、臓器7内の複数の箇所への多点投与を実現することができる。
In the first embodiment, the outer needle 10 having an outer diameter larger than that of the inner needle 11 is attached to the living tissue only when the puncture needle 2 is introduced into the living tissue and when the puncture needle 2 is extracted from the living tissue. Move forward and backward. Therefore, according to the first embodiment, multipoint administration to a plurality of locations in the organ 7 can be realized while reducing the invasion of the organ 7 by the outer needle 10 having a large outer diameter.
なお、実施の形態1においては、上述した図8のステップS4およびステップS5を並行して行ってもよい。すなわち、内針11を外針10に対して後退させるときにも、シリンジ5に対してプランジャ8を回転させて、薬剤の圧力を保った状態で内針11を後退させるように操作して、少なくとも内針11が第2の状態であり、かつ、内針11が外針10に対して後退しているときに薬剤を吐出させるようにしてもよい。このように操作することによって、図10に模式的に示すように、後退する内針11の軌跡において形成される空間、すなわち、図10の略円錐形の底面の周L1に加えて該略円錐形の側面L2に対応する空間にも薬剤を充填できるので、生体組織に対する薬剤の充填効率を高めることができる。
In the first embodiment, step S4 and step S5 in FIG. 8 described above may be performed in parallel. That is, when the inner needle 11 is moved backward with respect to the outer needle 10, the plunger 8 is rotated with respect to the syringe 5, and the inner needle 11 is moved backward while maintaining the pressure of the medicine. You may make it discharge a chemical | medical agent at least when the inner needle 11 is a 2nd state and the inner needle 11 has retracted | retreated with respect to the outer needle 10. FIG. By operating in this way, as schematically shown in FIG. 10, in addition to the space formed in the locus of the retreating inner needle 11, that is, the substantially conical bottom circumference L1 in FIG. Since the medicine corresponding to the side surface L2 of the shape can be filled with the medicine, the filling efficiency of the medicine into the living tissue can be increased.
(実施の形態1の変形例1)
実施の形態1の変形例1について説明する。実施の形態1の変形例1においては、図7に示すシリンジ5に代えて、図11および図12に示すように、バネ107を介して係合部材106が取り付けられるシリンジ105を用いてもよい。 (Modification 1 of Embodiment 1)
A first modification of the first embodiment will be described. In the first modification of the first embodiment, instead of thesyringe 5 shown in FIG. 7, as shown in FIGS. 11 and 12, a syringe 105 to which an engagement member 106 is attached via a spring 107 may be used. .
実施の形態1の変形例1について説明する。実施の形態1の変形例1においては、図7に示すシリンジ5に代えて、図11および図12に示すように、バネ107を介して係合部材106が取り付けられるシリンジ105を用いてもよい。 (
A first modification of the first embodiment will be described. In the first modification of the first embodiment, instead of the
シリンジ105は、基端のグリップに、内側がプランジャ8の雄ネジ8aに当接する当接部105aが形成される。当接部105aの外側にはバネ107の一端が嵌まる突起部105bが形成される。シリンジ105のグリップには、グリップの一部が延伸し屈曲したつまみ部105cが形成される。
In the syringe 105, a contact portion 105a is formed on the grip at the base end so that the inside contacts the male screw 8a of the plunger 8. A protrusion 105b into which one end of the spring 107 is fitted is formed on the outside of the contact portion 105a. The grip of the syringe 105 is formed with a knob portion 105c in which a part of the grip is extended and bent.
係合部材106は、プランジャ8が挿通可能である開口側面の一部に、雄ネジ8aに嵌合可能である雌ネジ部106aが形成される。係合部材106の開口側面には、雌ネジ部106aに対向して、バネ107の他端が嵌まる突起部106bが形成される。係合部材106には、一部が延伸し屈曲したつまみ部106cが形成される。つまみ部105cとつまみ部106cは、組み立て時には、図12に示すように対向する。
The engaging member 106 is formed with a female screw portion 106a that can be fitted to the male screw 8a on a part of the opening side surface through which the plunger 8 can be inserted. On the opening side surface of the engaging member 106, a protruding portion 106 b is formed so as to face the female screw portion 106 a and into which the other end of the spring 107 is fitted. The engaging member 106 is formed with a knob portion 106c that is partially extended and bent. The knob portion 105c and the knob portion 106c face each other as shown in FIG.
図12の矢印Y1のように、シリンジ105のつまみ部105cと係合部材106のつまみ部106cとが内側に押し付けられるようにつままれることによって、つまみ部106cが内側に移動し、これにともない、雌ネジ部106aも外側に移動する。この結果、雌ネジ部106aの雄ネジ8aへの嵌合が解除されて、プランジャ8は自由となり、矢印Y2のように上下に移動可能となる。
As indicated by an arrow Y1 in FIG. 12, the knob portion 105c of the syringe 105 and the knob portion 106c of the engaging member 106 are pinched so as to be pressed inward, whereby the knob portion 106c moves inward, and accordingly, The female screw portion 106a also moves outward. As a result, the fitting of the female screw portion 106a to the male screw 8a is released, and the plunger 8 becomes free and can move up and down as indicated by the arrow Y2.
そして、つまみ部105cとつまみ部106cとのつまみが解除されると、縮んでいたバネ107が伸びて雌ネジ部106aがプランジャ8の雄ネジ8aに嵌合する。この状態で実施の形態1と同様にプランジャ8をシリンジ105に対して前進するように回転することによって、薬剤等をシリンジ105から吐出可能である。
When the knob 105c and the knob 106c are released, the spring 107 that has been contracted is extended, and the female screw 106a is engaged with the male screw 8a of the plunger 8. In this state, the drug or the like can be discharged from the syringe 105 by rotating the plunger 8 so as to move forward with respect to the syringe 105 as in the first embodiment.
実施の形態1の変形例1においては、つまみ部105cおよびつまみ部106cをつまむだけで、プランジャ8をシリンジ105から取り外すことができるため、シリンジ105内への薬剤補充処理などの処理も容易に行うことができる。
In the first modification of the first embodiment, since the plunger 8 can be detached from the syringe 105 by simply pinching the knob portion 105c and the knob portion 106c, processing such as drug replenishment processing into the syringe 105 is also easily performed. be able to.
(実施の形態1の変形例2)
次に、実施の形態1の変形例2について説明する。図13に示すように、実施の形態1の変形例2にかかる薬剤投与装置1aにおいては、図1に示すシリンジ5およびプランジャ8に代えて、ポンプ17と、薬剤を格納するレザバー18とを有する薬剤送出ユニットを有する。ポンプ17は、レザバー18に収容された薬剤を内針11に送出する機能を有する。 (Modification 2 of Embodiment 1)
Next, a second modification of the first embodiment will be described. As shown in FIG. 13, thedrug administration device 1a according to the second modification of the first embodiment includes a pump 17 and a reservoir 18 that stores a drug instead of the syringe 5 and the plunger 8 illustrated in FIG. 1. It has a drug delivery unit. The pump 17 has a function of sending the medicine stored in the reservoir 18 to the inner needle 11.
次に、実施の形態1の変形例2について説明する。図13に示すように、実施の形態1の変形例2にかかる薬剤投与装置1aにおいては、図1に示すシリンジ5およびプランジャ8に代えて、ポンプ17と、薬剤を格納するレザバー18とを有する薬剤送出ユニットを有する。ポンプ17は、レザバー18に収容された薬剤を内針11に送出する機能を有する。 (
Next, a second modification of the first embodiment will be described. As shown in FIG. 13, the
このポンプ17は、制御ユニット19によって送出処理が制御される。制御ユニット19には、外針10と内針11との相対的な位置関係を検出するセンサー20が接続されている。
This pump 17 is controlled by the control unit 19 for delivery processing. A sensor 20 that detects the relative positional relationship between the outer needle 10 and the inner needle 11 is connected to the control unit 19.
制御ユニット19は、センサー20の検出結果をもとに、内針11が外針10の開口からその先端部が突出した第2の状態にあることを検出し、かつ、内針11が最も前進した位置にいる、または、内針11が一度最も前進した位置に到達した後に外針10の開口13に向かって後退している位置にいることを検出した場合に、予め設定した圧力で薬剤を送出するようにポンプ17を制御する。
Based on the detection result of the sensor 20, the control unit 19 detects that the inner needle 11 is in the second state in which the tip portion protrudes from the opening of the outer needle 10, and the inner needle 11 moves forward most. At the position where the inner needle 11 has reached the most advanced position once, or when it is detected that the inner needle 11 is retracted toward the opening 13 of the outer needle 10, The pump 17 is controlled to deliver.
このように、外針10と内針11との相対的位置をセンサー20で検出し、その検出した位置に応じて薬剤の吐出を自動的に行うように構成することによって、内針11が最も前進した位置で自動的に薬剤を投与できるとともに、内針11の後退軌跡において形成される空間にも薬剤を充填できるので、生体組織に対する薬剤の充填効率を高めることができる。
In this way, the relative position between the outer needle 10 and the inner needle 11 is detected by the sensor 20, and the medicine is automatically ejected according to the detected position. Since the medicine can be automatically administered at the advanced position and the medicine can be filled into the space formed in the backward locus of the inner needle 11, the filling efficiency of the medicine into the living tissue can be increased.
(実施の形態1の変形例3)
次に、実施の形態1の変形例3について説明する。図14は、実施の形態1の変形例3における穿刺針の先端部分を、該穿刺針の長手方向の中心軸に沿って切断した断面図である。 (Modification 3 of Embodiment 1)
Next, a third modification of the first embodiment will be described. FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle inModification 3 of Embodiment 1 cut along the central axis in the longitudinal direction of the puncture needle.
次に、実施の形態1の変形例3について説明する。図14は、実施の形態1の変形例3における穿刺針の先端部分を、該穿刺針の長手方向の中心軸に沿って切断した断面図である。 (
Next, a third modification of the first embodiment will be described. FIG. 14 is a cross-sectional view of the distal end portion of the puncture needle in
図14に示すように、実施の形態1の変形例3における外針10Aは、内部に第1のルーメン12a、12bを有するとともに、第1のルーメン12a,12bにそれぞれ連通する開口13a,13bを側面に有する。また、第1のルーメン12a,12bには、それぞれ内針11A,11Bが挿通される。この2つの内針11A,11Bは、それぞれ独立した進退運動が可能であるとともに、図示しない基端において、チューブおよびシリンジがそれぞれ接続しており、それぞれ独立して薬剤投与を行う。
As shown in FIG. 14, the outer needle 10A according to the third modification of the first embodiment has first lumens 12a and 12b inside, and openings 13a and 13b communicating with the first lumens 12a and 12b, respectively. On the side. Further, the inner needles 11A and 11B are inserted through the first lumens 12a and 12b, respectively. The two inner needles 11A and 11B can be moved forward and backward independently, and at the proximal end (not shown), a tube and a syringe are connected to each other, and drug administration is performed independently.
このように、複数の第1のルーメン12a,12b、開口13a,13bを設け、内針11A,11Bにおける進退運動および薬剤投与処理を独立して制御することによって、臓器7内の複数の箇所への多点投与を容易に実現することができる。
As described above, the plurality of first lumens 12a and 12b and the openings 13a and 13b are provided, and the advancing / retreating movements and the drug administration process in the inner needles 11A and 11B are independently controlled, so that the plurality of locations in the organ 7 Can be easily realized.
なお、図15の外針10Cに示すように、内部の第1のルーメン12cを先端で分岐させてもよい。この場合、第1のルーメン12cを非対称に分岐させて、各分岐した第1のルーメン12cとそれぞれ連通するとともに外針10Cの長手方向における位置がそれぞれ異なる開口13c,13dを外針10Cの側面に設けてもよい。そして、この場合には、第2のルーメン14cを有するとともに、複数の開口13c,13dに対応して先端が分岐した内針11Cを用いる。さらに、内針11Cの一方の先端11cを第1のルーメン12cから開口13cに誘導するガイド面10cと、内針11Cの他方の先端11dを第1のルーメン12cから開口13dに誘導するガイド面10dとを、それぞれ異なる角度に傾斜するように形成することによって、内針11Cの先端11c,11dの各開口13c,13dからの突出角度を変えてもよい。
Note that, as shown in the outer needle 10C of FIG. 15, the inner first lumen 12c may be branched at the tip. In this case, the first lumen 12c is branched asymmetrically to communicate with the branched first lumens 12c, and the openings 13c and 13d having different positions in the longitudinal direction of the outer needle 10C are provided on the side surfaces of the outer needle 10C. It may be provided. In this case, an inner needle 11C having a second lumen 14c and having a distal end branched corresponding to the plurality of openings 13c and 13d is used. Further, a guide surface 10c for guiding one tip 11c of the inner needle 11C from the first lumen 12c to the opening 13c, and a guide surface 10d for guiding the other tip 11d of the inner needle 11C from the first lumen 12c to the opening 13d. May be formed so as to be inclined at different angles, thereby changing the protrusion angle of the tips 11c and 11d of the inner needle 11C from the openings 13c and 13d.
(実施の形態2)
次に、実施の形態2について説明する。実施の形態2においては、内針が、外針の第1のルーメンに内針の先端部が収容される第1の状態にあるときにのみ、内針の運動と外針の長手軸中心の回動運動を連携させる連携機構を設けた場合について説明する。 (Embodiment 2)
Next, a second embodiment will be described. InEmbodiment 2, the movement of the inner needle and the center of the longitudinal axis of the outer needle are only when the inner needle is in the first state in which the tip of the inner needle is accommodated in the first lumen of the outer needle. The case where the cooperation mechanism which cooperates rotational movement is provided is demonstrated.
次に、実施の形態2について説明する。実施の形態2においては、内針が、外針の第1のルーメンに内針の先端部が収容される第1の状態にあるときにのみ、内針の運動と外針の長手軸中心の回動運動を連携させる連携機構を設けた場合について説明する。 (Embodiment 2)
Next, a second embodiment will be described. In
図16は、実施の形態2にかかる薬剤投与装置の分解斜視図である。図17および図18は、図16に示す薬剤投与装置201の基端側要部を長手方向の中心軸に沿って切断した断面図である。図17は、薬剤投与装置201の基端側要部を分解した状態について示す。図18は、薬剤投与装置201の基端側要部が組みつけられた状態であり、後述するプッシャが後述するプランジャ内に最も押し入れられた状態を示す。
FIG. 16 is an exploded perspective view of the drug administration device according to the second embodiment. 17 and 18 are cross-sectional views of the main part on the proximal end side of the drug administration device 201 shown in FIG. 16 cut along the central axis in the longitudinal direction. FIG. 17 shows a state in which the main part on the proximal end side of the drug administration device 201 is disassembled. FIG. 18 shows a state in which the main part of the proximal end of the drug administration device 201 is assembled, and shows a state in which a pusher described later is pushed most into a plunger described later.
図16~図18に示すように、薬剤投与装置201は、内部に内針11を収容可能である外針10、外針10を内部ルーメンに収容する外筒202、略円筒形のベース部材222、略円筒形のチャージグリップ223を有する。
As shown in FIGS. 16 to 18, the drug administration device 201 includes an outer needle 10 that can accommodate the inner needle 11 therein, an outer cylinder 202 that accommodates the outer needle 10 in the inner lumen, and a substantially cylindrical base member 222. And a substantially cylindrical charge grip 223.
図16~図18に示すように、チャージグリップ223は外周に滑り止め溝が加工されている。また、チャージグリップ223は、ベース部材222に対し回動できる構造となっている。
As shown in FIGS. 16 to 18, the charge grip 223 has a non-slip groove formed on the outer periphery. Further, the charge grip 223 has a structure that can rotate with respect to the base member 222.
ベース部材222内部の空洞は、先端側と基端側とで内径が異なり、基端側の空洞222aの方が径大である。空洞222aの内側面には、内側面を一周するカム溝228が形成されている。このカム溝228は、軸方向に伸長する複数の直線溝と、各線溝の基端と、各直線溝と隣り合う一方の直線溝の先端とをそれぞれ接続する溝であって複数の直線溝間を斜めに結ぶ複数の傾斜溝とによって形成される。ベース部材222先端は、外筒202と連結する。外筒202は、外針10を回動自在にルーメン内に収容する。外筒202は、例えばPEEK樹脂チューブである。
The inner cavity of the base member 222 has different inner diameters on the distal end side and the proximal end side, and the proximal end side cavity 222a has a larger diameter. A cam groove 228 that goes around the inner surface is formed on the inner surface of the cavity 222a. The cam groove 228 is a groove that connects a plurality of linear grooves extending in the axial direction, a base end of each linear groove, and a tip of one linear groove adjacent to each linear groove. Are formed by a plurality of inclined grooves that are diagonally connected to each other. The tip of the base member 222 is connected to the outer cylinder 202. The outer cylinder 202 accommodates the outer needle 10 in a lumen so as to be rotatable. The outer cylinder 202 is, for example, a PEEK resin tube.
シリンジ224は、内部に空洞を有するとともに、少なくとも先端部がベース部材222の空洞222aに回動自在に収容される小径部224aと、小径部224aに連なる径大の大径部224bとを有する。小径部224aの先端は、外針10の基端が連結している。大径部224b内部の空洞224cの内側面には、長手軸方向に延伸する直線形状のガイド溝226が形成されている。
The syringe 224 has a hollow inside, and has a small-diameter portion 224a in which at least a tip portion is rotatably accommodated in the cavity 222a of the base member 222, and a large-diameter portion 224b having a large diameter connected to the small-diameter portion 224a. The proximal end of the outer needle 10 is connected to the distal end of the small diameter portion 224a. A linear guide groove 226 extending in the longitudinal axis direction is formed on the inner surface of the cavity 224c inside the large diameter portion 224b.
小径部224aの外側面には、カム溝228と係合可能である係合ピン229が設けられている。この係合ピン229は、図17の矢印に示すように、外部に突出するように付勢されているとともに、上部から押された場合には小径部224aの外壁内に収容されるように構成される。
An engaging pin 229 that can engage with the cam groove 228 is provided on the outer surface of the small diameter portion 224a. As shown by the arrow in FIG. 17, the engaging pin 229 is urged so as to protrude to the outside, and is configured to be accommodated in the outer wall of the small-diameter portion 224a when pushed from above. Is done.
シリンジ224の先端部は、係合ピン229が小径部224aの外壁内に収容された状態で、収容された係合ピン229がベース部材222のカム溝228に到達するまで、ベース部材222の空洞222aに挿入される。外部方向に付勢された係合ピン229は、カム溝228に到達すると突出し、カム溝228に係合する。係合ピン229は、カム溝228の溝の中を移動して、ベース部材222の内側面を一周することができる。この係合ピン229の移動にともなって、シリンジ224本体もカム溝228の輪郭に沿って回動可能である。そして、小径部224aの先端は外針10の基端が連結しているため、この外針10も、シリンジ224と一体となって回動する。
The distal end portion of the syringe 224 is a cavity of the base member 222 until the received engaging pin 229 reaches the cam groove 228 of the base member 222 in a state where the engaging pin 229 is received in the outer wall of the small diameter portion 224a. 222a is inserted. The engaging pin 229 biased in the outward direction protrudes when it reaches the cam groove 228 and engages with the cam groove 228. The engaging pin 229 can move in the groove of the cam groove 228 to make a round of the inner surface of the base member 222. As the engagement pin 229 moves, the syringe 224 main body can also rotate along the contour of the cam groove 228. Since the proximal end of the outer needle 10 is connected to the distal end of the small diameter portion 224a, the outer needle 10 also rotates integrally with the syringe 224.
プランジャ225は、略円筒形状を有するとともに、少なくとも先端部がシリンジ224の空洞224cに回動自在に収容される。プランジャ225の外側面には、シリンジ224のガイド溝226と係合する係合ピン227が設けられている。プランジャ225の先端には、内針11の基端が連結しており、プランジャ225と内針11とは一体的に動く。
The plunger 225 has a substantially cylindrical shape, and at least a tip portion is rotatably accommodated in the cavity 224c of the syringe 224. An engagement pin 227 that engages with the guide groove 226 of the syringe 224 is provided on the outer surface of the plunger 225. The proximal end of the inner needle 11 is connected to the distal end of the plunger 225, and the plunger 225 and the inner needle 11 move integrally.
プッシャ225aは、プランジャ225の基端側からプランジャ225の空洞224c内に挿入され、薬剤吐出時には、操作者によって先端側に向かって押される。プッシャ225aの基端側側面には、レザバー18と接続するチューブ204が連結している。
The pusher 225a is inserted into the cavity 224c of the plunger 225 from the proximal end side of the plunger 225, and is pushed toward the distal end side by the operator when the medicine is discharged. A tube 204 connected to the reservoir 18 is connected to the side surface on the proximal end side of the pusher 225a.
チューブ204とプランジャ225の空洞との境界には、チューブ204からプランジャ225内に向かう方向の圧力が加えられたときにチューブ204内部の薬剤等をプランジャ225内に向かって通過させる一方向弁234が設けられる。すなわち、一方向弁234は、プッシャ225aがプランジャ225から引き出されるときに、薬剤等をプランジャ225の空洞内に向かって通過させる。
At the boundary between the tube 204 and the cavity of the plunger 225, there is a one-way valve 234 that allows a drug or the like in the tube 204 to pass into the plunger 225 when pressure in the direction from the tube 204 into the plunger 225 is applied. Provided. That is, the one-way valve 234 allows the medicine or the like to pass into the cavity of the plunger 225 when the pusher 225 a is pulled out from the plunger 225.
また、プランジャ225の空洞の先端部には、プランジャ225内から先端方向に向かう方向の力が加えられたときに、プランジャ225内部の薬剤等を外部に向かう方向に通過させる一方向弁235が設けられる。すなわち、一方向弁235は、プッシャ225aがプランジャ225内に押し入れられたときに、プランジャ225内の薬剤等をプランジャ225先端から吐出させる。
In addition, a one-way valve 235 is provided at the distal end of the cavity of the plunger 225 so that when a force in the direction from the plunger 225 toward the distal direction is applied, the medicine in the plunger 225 passes in the direction toward the outside. It is done. That is, the one-way valve 235 discharges the medicine or the like in the plunger 225 from the tip of the plunger 225 when the pusher 225a is pushed into the plunger 225.
シリンジ224の外側面には、第1のバネ230が配設されている。第1のバネ230は、先端側端部230aがチャージグリップ223の基端側底面に固定され、基端側端部230bがシリンジ224の大径部224bに固定されている。
A first spring 230 is disposed on the outer surface of the syringe 224. As for the 1st spring 230, the front end side edge part 230a is being fixed to the base end side bottom face of the charge grip 223, and the base end side end part 230b is being fixed to the large diameter part 224b of the syringe 224.
ここで、図19は、図17のA-A線切断図である。図19に示すように、ベース部材222の外側面には、カム溝228よりも先端側に穴222dが形成される。また、チャージグリップ223の内側面には、カム溝228よりも先端側に穴223bが形成される。この穴222d,223bは、両者間に介在する係合部材232によって係合しており、チャージグリップ223は、ベース部材222に対し、一方向には回動するが、逆の方向には回動しないように構成されている。係合部材232は、たとえば、1個のバネと1個のボールとを1組として形成される。
Here, FIG. 19 is a sectional view taken along line AA of FIG. As shown in FIG. 19, a hole 222 d is formed on the outer surface of the base member 222 on the tip side of the cam groove 228. Further, a hole 223 b is formed on the inner side surface of the charge grip 223 on the tip side of the cam groove 228. The holes 222d and 223b are engaged by an engaging member 232 interposed therebetween, and the charge grip 223 rotates in one direction with respect to the base member 222, but rotates in the opposite direction. It is configured not to. For example, the engaging member 232 is formed as a set of one spring and one ball.
このような係合部材232でベース部材222とチャージグリップ223とを係合するため、回転可能な方向にチャージグリップ223およびシリンジ224を回動させると、回動のエネルギーが第1のバネ230にチャージされる。シリンジ224には外針10が連結するため、図19に示す係合部材232は、外針10を一定の方向に回動するように付勢する付勢機構として機能する。
Since the engaging member 232 engages the base member 222 and the charge grip 223, when the charge grip 223 and the syringe 224 are rotated in a rotatable direction, the energy of rotation is applied to the first spring 230. Charged. Since the outer needle 10 is connected to the syringe 224, the engaging member 232 shown in FIG. 19 functions as an urging mechanism that urges the outer needle 10 to rotate in a certain direction.
プランジャ225の外側面には、第2のバネ231が配設されている。第2のバネ231は、基端側端部はプランジャ225の基端に固定されており、先端側端部は移動が自由となるように固定されていない。プランジャ225がシリンジ224内部に押し込まれると、第2のバネ231が縮むことで基端方向に向かうエネルギーがチャージされ、プランジャ225は押し戻す方向に付勢される。
A second spring 231 is disposed on the outer surface of the plunger 225. As for the 2nd spring 231, the base end side edge part is being fixed to the base end of the plunger 225, and the front end side edge part is not being fixed so that a movement becomes free. When the plunger 225 is pushed into the syringe 224, the energy toward the proximal direction is charged by the second spring 231 contracting, and the plunger 225 is urged in the pushing back direction.
プッシャ225aには、第3のバネ233が配設されている。プッシャ225aがプランジャ225内部に押し込まれると、第3のバネ233が縮むことで基端方向に向かうエネルギーがチャージされ、プッシャ225aは押し戻す方向に付勢される。
A third spring 233 is disposed on the pusher 225a. When the pusher 225a is pushed into the plunger 225, the third spring 233 contracts to charge energy in the proximal direction, and the pusher 225a is urged in the pushing back direction.
第2のバネ231は、第1のバネ230に比べて強い弾性を有するバネである。第3のバネ233は、第2のバネ231に比べてさらに強い弾性を有するバネである。
The second spring 231 is a spring having stronger elasticity than the first spring 230. The third spring 233 is a spring having even stronger elasticity than the second spring 231.
次に、図20を参照して、薬剤投与装置201の基端側の各構成要素の動作を説明する。図20は、ベース部材222の空洞222aの内側面に形成されたカム溝228を示す図である。
Next, with reference to FIG. 20, the operation of each component on the proximal end side of the drug administration device 201 will be described. FIG. 20 is a diagram illustrating the cam groove 228 formed on the inner surface of the cavity 222 a of the base member 222.
まず、初期状態として、カム溝228において、係合ピン229は、位置A(図20参照)に位置する。この状態で、プッシャ225aが押されると、プッシャ225aを押す力は、第3のバネ233および第2のバネ231を介してシリンジ224に伝達して、シリンジ224を押す力となる。シリンジ224が押されることによって、係合ピン229にも、先端側に押される力がかかり、係合ピン229は、カム溝228の傾斜溝部分に沿ってカム溝228の位置Bの位置まで移動する。したがって、係合ピン229が傾斜溝部分に沿ってベース部材222の外側面を斜めに回動するように移動するため、シリンジ224もベース部材222の空洞222a内で回動する。図18の紙面との直交面から見たときにシリンジ224が回動する角度は、例えば30°から180°が望ましい。そして、シリンジ224が押されることにともない、第1のバネ230は収縮する。
First, as an initial state, in the cam groove 228, the engagement pin 229 is located at the position A (see FIG. 20). When the pusher 225a is pushed in this state, the force pushing the pusher 225a is transmitted to the syringe 224 via the third spring 233 and the second spring 231 and becomes the force pushing the syringe 224. When the syringe 224 is pushed, the engaging pin 229 is also pushed to the tip side, and the engaging pin 229 moves along the inclined groove portion of the cam groove 228 to the position B of the cam groove 228. To do. Accordingly, since the engaging pin 229 moves along the inclined groove portion so as to rotate obliquely on the outer surface of the base member 222, the syringe 224 also rotates within the cavity 222a of the base member 222. The angle at which the syringe 224 rotates when viewed from a plane orthogonal to the paper surface of FIG. 18 is preferably, for example, 30 ° to 180 °. Then, as the syringe 224 is pushed, the first spring 230 contracts.
この場合、第1のバネ230が最も収縮した状態に至るまでの間、第2のバネ231は、僅かな収縮に留まるにすぎないため、内針11先端は、外針10から突出することはない。このため、内針11の先端は外針10の第1のルーメン内に収容されたままの状態で、外針10が回動する。もちろん、第3のバネ233は、さらに僅かに収縮するのみであるため、薬液の吐出は行われない。
In this case, since the second spring 231 is only slightly contracted until the first spring 230 reaches the most contracted state, the tip of the inner needle 11 does not protrude from the outer needle 10. Absent. For this reason, the outer needle 10 rotates while the tip of the inner needle 11 remains housed in the first lumen of the outer needle 10. Of course, since the third spring 233 only slightly contracts, the chemical solution is not discharged.
さらに強くプッシャ225aが押されると、プッシャ225aを押す力は、第3のバネ233を介してプランジャ225に伝達してプランジャ225を押す力となり、プランジャ225がシリンジ224内部を先端方向に向かって前進する。これにともない、プランジャ225外側面に設けられた第2のバネ231が収縮を開始する。このとき、係合ピン227がガイド溝226先端まで前進し、これにともない、プランジャ225先端に連結する内針11も前進し、内針11の先端が外針10の開口13から突出する。内針11の先端の突出は、ガイド溝226の先端で係合ピン227の前進が止まると停止する。
When the pusher 225a is further strongly pressed, the force pushing the pusher 225a is transmitted to the plunger 225 via the third spring 233 and pushes the plunger 225, and the plunger 225 moves forward in the syringe 224 toward the distal end. To do. Along with this, the second spring 231 provided on the outer surface of the plunger 225 starts to contract. At this time, the engaging pin 227 advances to the tip of the guide groove 226, and accordingly, the inner needle 11 connected to the tip of the plunger 225 also advances, and the tip of the inner needle 11 protrudes from the opening 13 of the outer needle 10. The protrusion of the tip of the inner needle 11 stops when the advance of the engagement pin 227 stops at the tip of the guide groove 226.
この場合、第3のバネ233は、さらに僅かに収縮するのみであるため、薬液の吐出は行われない。なお、第2のバネ231および第3のバネ233で付勢されている部材に予めストッパを設けてストロークを制限する構成、つまり動作開始前においても先端側に若干押す力がかかっている状態にしてもよい。この場合には、第2のバネ231および第3のバネ233の収縮に関わる各部材の動きは、一つのバネに関わる動きが完了してから次のバネに関わる動きが開始されるため、各部材はさらに規則的に動作する。すなわち、第2のバネ231は、第1のバネ230の収縮に関する部材の動き(シリンジ224の回動動作)が完了してから、収縮を開始する。そして、第3のバネ233は、第2のバネ231の収縮に関する部材の動き(内針11の突出動作)が完了してから収縮を開始する。
In this case, since the third spring 233 contracts slightly further, the chemical solution is not discharged. In addition, the member that is urged by the second spring 231 and the third spring 233 is provided with a stopper in advance to limit the stroke, that is, a state in which a slight pressing force is applied to the distal end side even before the operation is started. May be. In this case, the movement of each member related to the contraction of the second spring 231 and the third spring 233 starts after the movement related to one spring is completed, and thus the movement related to the next spring is started. The member operates more regularly. That is, the second spring 231 starts to contract after the movement of the member related to the contraction of the first spring 230 (the rotation operation of the syringe 224) is completed. The third spring 233 starts to contract after the movement of the member related to the contraction of the second spring 231 (the protruding operation of the inner needle 11) is completed.
さらに強くプッシャ225aが押されると、第3のバネ233が収縮し、プッシャ225aがプランジャ225内に押し入れられる。この結果、プランジャ225内には、プランジャ225内から先端方向に向かう方向の力が加えられ、一方向弁235を経由して、プランジャ225内の薬剤等がプランジャ225先端から吐出される。プランジャ225先端から吐出された薬剤等は、内針11の内部ルーメンを流れ、内針11の先端から生体組織に向けて吐出される。
When the pusher 225a is pushed more strongly, the third spring 233 contracts and the pusher 225a is pushed into the plunger 225. As a result, a force in the direction from the plunger 225 toward the distal end is applied to the plunger 225, and the medicine or the like in the plunger 225 is discharged from the plunger 225 distal end via the one-way valve 235. The medicine or the like discharged from the distal end of the plunger 225 flows through the inner lumen of the inner needle 11 and is discharged toward the living tissue from the distal end of the inner needle 11.
その後、プッシャ225aから操作者が指を離すと、プッシャ225aを押す力が解除されるため、まず、第3のバネ233に蓄えられた弾性エネルギーによってプッシャ225aが基端方向に後退する。このプッシャ225aの後退によって、チューブ204からプランジャ225内に向かう方向の圧力が加えられるため、一方向弁234を経由してチューブ204からプランジャ225内に薬剤が供給される。
After that, when the operator releases the finger from the pusher 225a, the force pushing the pusher 225a is released, so that the pusher 225a is first retracted in the proximal direction by the elastic energy stored in the third spring 233. Since the pressure in the direction from the tube 204 into the plunger 225 is applied by the retraction of the pusher 225a, the medicine is supplied from the tube 204 into the plunger 225 via the one-way valve 234.
続いて、第2のバネ231に蓄えられた弾性エネルギーによって、プランジャ225は基端方向に後退する。プランジャ225先端に接続する内針11も後退する。この結果、内針11の先端は、外針10の開口13を経由して外針10の内部に再び収容される。その後、第1のバネ230に蓄えられた弾性エネルギーによって、シリンジ224は、基端方向に後退して、初期状態に復帰する。このシリンジ224の後退によって、係合ピン229は、カム溝228において位置Bから位置Cまで後退移動する。
Subsequently, the plunger 225 moves backward in the proximal direction by the elastic energy stored in the second spring 231. The inner needle 11 connected to the distal end of the plunger 225 is also retracted. As a result, the tip of the inner needle 11 is accommodated again in the outer needle 10 via the opening 13 of the outer needle 10. Thereafter, the elastic energy stored in the first spring 230 causes the syringe 224 to retreat in the proximal direction and return to the initial state. By the retraction of the syringe 224, the engagement pin 229 moves backward from the position B to the position C in the cam groove 228.
係合ピン229がカム溝228の位置Cに到着すると、第1のバネ230に予めチャージされた回動エネルギーの作用によって、シリンジ224が僅かに回動する。この結果、係合ピン229の位置は、カム溝228の位置Cから位置Dに移動する。
When the engaging pin 229 arrives at the position C of the cam groove 228, the syringe 224 is slightly rotated by the action of the rotation energy charged in the first spring 230 in advance. As a result, the position of the engagement pin 229 moves from the position C of the cam groove 228 to the position D.
このように、実施の形態2においては、操作者がプランジャ225を押す動作を繰り返すことによって、外針10の軸周りの回動、外針10の開口13からの内針11の突出、内針11先端からの薬剤等の吐出、チューブ204からプランジャ225内への薬剤の供給、および、内針11の外針10の開口13内への収納のサイクルを繰り返すことができるため、臓器7内の複数の箇所への多点投与をさらに容易に実現することができる。
As described above, in the second embodiment, when the operator repeatedly presses the plunger 225, the outer needle 10 rotates around the axis, the inner needle 11 protrudes from the opening 13 of the outer needle 10, and the inner needle. 11 It is possible to repeat a discharge cycle of the medicine from the tip, supply of the medicine from the tube 204 into the plunger 225, and storage of the inner needle 11 into the opening 13 of the outer needle 10, so Multipoint administration to a plurality of locations can be realized more easily.
(実施の形態3)
次に、実施の形態3について説明する。図21は、実施の形態3にかかる薬剤投与装置の基端側要部を長手方向の中心軸に沿って切断した断面図である。 (Embodiment 3)
Next,Embodiment 3 will be described. FIG. 21 is a cross-sectional view of the base-end-side main part of the drug administration device according to the third embodiment, cut along the central axis in the longitudinal direction.
次に、実施の形態3について説明する。図21は、実施の形態3にかかる薬剤投与装置の基端側要部を長手方向の中心軸に沿って切断した断面図である。 (Embodiment 3)
Next,
図21に示すように、実施の形態3にかかる薬剤投与装置は、実施の形態2にかかる薬剤投与装置201と比して、図16~図18に示す第3のバネ233を省略した構成を有する。薬剤投与装置301は、図16~図18に示すプッシャ225aに代えて、図7に示すプランジャ8をプッシャとして有する。薬剤投与装置301は、図16~図18に示すプランジャ225に代えて、内部にプランジャ8の雄ネジ8aが嵌る雌ネジ325aが基端側内部に形成されたプランジャ325を有する。
As shown in FIG. 21, the drug administration device according to the third embodiment has a configuration in which the third spring 233 shown in FIGS. 16 to 18 is omitted as compared with the drug administration device 201 according to the second embodiment. Have. The drug administration device 301 has a plunger 8 shown in FIG. 7 as a pusher in place of the pusher 225a shown in FIGS. In place of the plunger 225 shown in FIGS. 16 to 18, the drug administration device 301 includes a plunger 325 in which a female screw 325 a into which the male screw 8 a of the plunger 8 is fitted is formed in the proximal end side.
この実施の形態3によれば、プランジャ325に対して、プッシャとして機能するプランジャ8を回転させることによって、微量の薬剤を送出可能にしている。
According to the third embodiment, a small amount of medicine can be delivered by rotating the plunger 8 that functions as a pusher with respect to the plunger 325.
さらに、実施の形態3においては、ベース部材222とシリンジ224とプランジャ325とは、ロック機構によって相対的な位置関係がロックされる構成としてもよい。この場合、操作者はプランジャ325から手を離すことができる。そして、この状態でプランジャ8をプランジャ325に対して回転させることで薬剤の注入を実現する。
Furthermore, in Embodiment 3, the relative positional relationship between the base member 222, the syringe 224, and the plunger 325 may be locked by a lock mechanism. In this case, the operator can release his / her hand from the plunger 325. And in this state, injection | pouring of a chemical | medical agent is implement | achieved by rotating the plunger 8 with respect to the plunger 325. FIG.
操作者がプランジャ325を押すと、ロック機構が外れる。その後、操作者がプランジャ325から指を離すと、プランジャ325を押す力が解除されるため、第2のバネ231に蓄えられた弾性エネルギーによってプランジャ325は基端方向に後退する。続いて、第1のバネ230に蓄えられた弾性エネルギーによって、プランジャ325は、シリンジ224とともにさらに基端方向に後退して、初期状態に復帰する。この移動によって、係合ピン229は、カム溝228において位置B(図20参照)から位置C(図20参照)に後退する。この係合ピン229の後退にともなって、シリンジ224内に先端が収容されるプランジャ325も後退するため、プランジャ325先端に接続する内針11も後退し、内針11の先端は、外針10の内部に再び収容される。
When the operator pushes the plunger 325, the lock mechanism is released. Thereafter, when the operator removes his / her finger from the plunger 325, the force pushing the plunger 325 is released, so that the plunger 325 is retracted in the proximal direction by the elastic energy stored in the second spring 231. Subsequently, due to the elastic energy stored in the first spring 230, the plunger 325 is further retracted in the proximal direction together with the syringe 224, and returns to the initial state. By this movement, the engagement pin 229 moves backward from the position B (see FIG. 20) to the position C (see FIG. 20) in the cam groove 228. As the engagement pin 229 is retracted, the plunger 325 whose tip is accommodated in the syringe 224 is also retracted, so that the inner needle 11 connected to the distal end of the plunger 325 is also retracted, and the distal end of the inner needle 11 is the outer needle 10. Housed again inside.
(実施の形態4)
次に、実施の形態4について説明する。実施の形態4においては、実施の形態2,3とは異なる連携機構を設けた場合について説明する。 (Embodiment 4)
Next, a fourth embodiment will be described. In the fourth embodiment, a case where a cooperation mechanism different from the second and third embodiments is provided will be described.
次に、実施の形態4について説明する。実施の形態4においては、実施の形態2,3とは異なる連携機構を設けた場合について説明する。 (Embodiment 4)
Next, a fourth embodiment will be described. In the fourth embodiment, a case where a cooperation mechanism different from the second and third embodiments is provided will be described.
図22および図23は、本実施の形態4における穿刺針の先端部分の斜視図である。図24は、図22に示す穿刺針402の先端部分を、該穿刺針402の長手方向の中心軸に沿って切断した断面図である。図25は、図23に示す穿刺針402の先端部分を、該穿刺針402の長手方向の中心軸に沿って切断した断面図である。
22 and 23 are perspective views of the distal end portion of the puncture needle according to the fourth embodiment. FIG. 24 is a cross-sectional view of the distal end portion of the puncture needle 402 shown in FIG. 22 cut along the central axis in the longitudinal direction of the puncture needle 402. FIG. 25 is a cross-sectional view of the distal end portion of the puncture needle 402 shown in FIG. 23 taken along the central axis in the longitudinal direction of the puncture needle 402.
図22および図23に示すように、実施の形態4の穿刺針402は、開口13が側面に設けられるとともに内部に連携機構が設けられる先端部441と、先端部441に対して軸周りに回動自在の基端部442とを有する外針410を備える。連携機構は、外針410の先端部441のみを回動運動させるものであり、基端部442を回動させるものではない。
As shown in FIGS. 22 and 23, the puncture needle 402 according to the fourth embodiment has a distal end portion 441 in which an opening 13 is provided on a side surface and a cooperation mechanism is provided inside, and a rotation about an axis relative to the distal end portion 441. An outer needle 410 having a movable proximal end 442 is provided. The cooperation mechanism rotates only the distal end portion 441 of the outer needle 410, and does not rotate the proximal end portion 442.
内針411は、外針410の第1のルーメン412に進退運動可能に挿通される。内針411は、内針411の進退運動によって、外針410内に内針411の先端部が収容される第1の状態(図22および図24参照)と、外針410の開口13から少なくとも内針411の先端部の一部が突出する第2の状態(図23および図25参照)との間を遷移する。内針411の基端は、外針410の基端部442の第1のルーメン412を延伸する。内針411の基端は、実施の形態1と同様に、シリンジ5の内部空間と連通するチューブ4に連結する。
The inner needle 411 is inserted into the first lumen 412 of the outer needle 410 so as to be able to advance and retract. The inner needle 411 moves at least from the first state (see FIGS. 22 and 24) in which the distal end portion of the inner needle 411 is accommodated in the outer needle 410 by the forward and backward movement of the inner needle 411 and from the opening 13 of the outer needle 410. A transition is made between the second state (see FIGS. 23 and 25) in which a part of the tip of the inner needle 411 protrudes. The proximal end of the inner needle 411 extends the first lumen 412 of the proximal end portion 442 of the outer needle 410. The proximal end of the inner needle 411 is connected to the tube 4 communicating with the internal space of the syringe 5 as in the first embodiment.
内針411の外側面および外針410の第1のルーメン412の内側面には、それぞれが係合可能である係合機構が設けられる。図24および図25に示す例では、内針411の外表面に係合ピン443が設けられており、第1のルーメン412の内側面に、係合ピン443が係合可能である被係合部材444が設けられている。図24および図25に示すように、係合ピン443と被係合部材444とは、内針11が外針410内に内針11の先端部が収容される第1の状態であるときにのみ係合する位置関係にある。
An engagement mechanism is provided on the outer surface of the inner needle 411 and the inner surface of the first lumen 412 of the outer needle 410 so that they can be engaged with each other. In the example shown in FIGS. 24 and 25, the engagement pin 443 is provided on the outer surface of the inner needle 411, and the engagement pin 443 can be engaged with the inner surface of the first lumen 412. A member 444 is provided. As shown in FIGS. 24 and 25, the engagement pin 443 and the engaged member 444 are when the inner needle 11 is in the first state in which the distal end portion of the inner needle 11 is accommodated in the outer needle 410. It is in a positional relationship that only engages.
外針410の内側面であって被係合部材444よりも先端側には、係合ピン443の前進を阻止可能であるストッパ445が設けられており、内針411の先端が過度に突出するのを防止している。
A stopper 445 that can prevent the engagement pin 443 from moving forward is provided on the inner surface of the outer needle 410 and on the distal end side of the engaged member 444, and the distal end of the inner needle 411 protrudes excessively. Is preventing.
図26は、図24および図25に示す被係合部材444の形状を説明する模式図である。図26は、説明のため、被係合部材444を図24および図25に示す状態から90°左周りに回転した状態を示す。
FIG. 26 is a schematic diagram for explaining the shape of the engaged member 444 shown in FIGS. 24 and 25. FIG. 26 shows a state where the engaged member 444 is rotated 90 ° counterclockwise from the state shown in FIGS. 24 and 25 for the sake of explanation.
図26に示すように、被係合部材444は、円筒の側面が山型に切り欠かれた形状を有する。切り欠き形状は、外針410の軸方向に平行な面と、外針410の軸方向に平行な面の基端と、この面と隣り合う他の外針410の軸方向に平行な面の先端とを接続する傾斜面とによって形成される。
As shown in FIG. 26, the engaged member 444 has a shape in which the side surface of the cylinder is notched into a mountain shape. The notch shape includes a surface parallel to the axial direction of the outer needle 410, a base end of a surface parallel to the axial direction of the outer needle 410, and a surface parallel to the axial direction of another outer needle 410 adjacent to this surface. It is formed by the inclined surface which connects a front-end | tip.
実施の形態4においては、操作者は、内針411を外針410に対して前進させる。この結果、図26の矢印Y41に示すように、内針411の係合ピン443も前進するため、内針411の係合ピン443と外針410の被係合部材444との係合が外れる。そして、操作者は、係合ピン443がストッパ445で止まるまで内針411をさらに前進させて、内針411の先端を外針410の開口13から突出させる第2の状態(図23および図25参照)としてから、薬剤を内針411の第2のルーメン14に供給して、投薬を行う。なお、この状態で操作者が内針411を回動させても、外針410は、被係合部材444が内針411の係合ピン443に係合していないため回動しない。
In Embodiment 4, the operator advances the inner needle 411 relative to the outer needle 410. As a result, as indicated by an arrow Y41 in FIG. 26, the engagement pin 443 of the inner needle 411 is also advanced, so that the engagement between the engagement pin 443 of the inner needle 411 and the engaged member 444 of the outer needle 410 is released. . Then, the operator further advances the inner needle 411 until the engagement pin 443 stops at the stopper 445, so that the tip of the inner needle 411 protrudes from the opening 13 of the outer needle 410 (FIGS. 23 and 25). After that, the medicine is supplied to the second lumen 14 of the inner needle 411 for dosing. Even if the operator rotates the inner needle 411 in this state, the outer needle 410 does not rotate because the engaged member 444 is not engaged with the engaging pin 443 of the inner needle 411.
続いて、操作者は、内針411を外針410に対して後退させて、内針411の先端を外針410の第1のルーメン412に収容する第1の状態(図22および図24参照)とする。操作者が、内針411の係合ピン443が被係合部材444に接触するまで内針411を後退させた後、内針411を所定方向に回動させる。
Subsequently, the operator retracts the inner needle 411 with respect to the outer needle 410, and stores the tip of the inner needle 411 in the first lumen 412 of the outer needle 410 (see FIGS. 22 and 24). ). After the operator retracts the inner needle 411 until the engaging pin 443 of the inner needle 411 contacts the engaged member 444, the operator rotates the inner needle 411 in a predetermined direction.
内針411を所定方向(たとえば図26の矢印Y42が向く方向)に回動すると、その回動運動は、被係合部材444の軸方向に平行な面に当たった係合ピン443によって被係合部材444に伝達され、これにともない、外針410も矢印Y42の方向に回動し、開口13の向く方向も変化する。ただし、内針411が他方向(たとえば、矢印Y42が向く方向とは逆方向)に回動しても、内針411の回動運動は、係合ピン443は被係合部材444の軸方向に平行な面に当たらないため、係合ピン443から被係合部材444に伝達されることはなく、外針410も回動しない。したがって、係合ピン443と被係合部材444とは、内針411が第1の状態にあるときに、内針411の回転運動によって外針410の回転運動を生じさせる係合機構として機能する。
When the inner needle 411 is rotated in a predetermined direction (for example, the direction in which the arrow Y42 in FIG. 26 is directed), the rotational movement is engaged by the engagement pin 443 that hits the surface parallel to the axial direction of the engaged member 444. As a result, the outer needle 410 is also rotated in the direction of the arrow Y42, and the direction in which the opening 13 is directed changes. However, even if the inner needle 411 rotates in the other direction (for example, the direction opposite to the direction in which the arrow Y42 faces), the rotation movement of the inner needle 411 causes the engagement pin 443 to move in the axial direction of the engaged member 444. Therefore, the outer pin 410 is not transmitted from the engaging pin 443 to the engaged member 444, and the outer needle 410 does not rotate. Therefore, the engagement pin 443 and the engaged member 444 function as an engagement mechanism that causes the outer needle 410 to rotate by the rotation of the inner needle 411 when the inner needle 411 is in the first state. .
このように、実施の形態4においては、操作者が内針411の前進、後退および所定の方向への回動を繰り返すことによって、外針410の開口13からの内針11の突出、内針411先端からの薬剤等の吐出、内針411の外針410の開口13内への収納、および、外針410の軸周りの回動のサイクルを繰り返すことができるため、臓器7内の複数の箇所への多点投与を容易に実現することができる。
As described above, in the fourth embodiment, when the operator repeats the forward movement, backward movement, and rotation in a predetermined direction of the inner needle 411, the inner needle 11 protrudes from the opening 13 of the outer needle 410, and the inner needle. Since the discharge of the medicine from the tip of 411, the storage of the inner needle 411 into the opening 13 of the outer needle 410, and the rotation cycle around the axis of the outer needle 410 can be repeated, a plurality of the internal needles 411 Multipoint administration to a location can be easily realized.
なお、実施の形態4においては、図26に示す被係合部材444よりも、外針410の軸方向に平行な面を傾斜面と同じ方向に傾斜させて、切り欠かれた山型形状の頂角をさらに鋭角化させた被係合部材444a(図27参照)を用いてもよい。そして、内針411が前進する際に被係合部材444aの山型形状の頂角部分を乗り越えられるように、係合ピン443に弾性を持たせればよい。また、外針410の被係合部材は、内針411を一方向に回動させたときに、その回動運動が係合ピン443によって伝達されるように、後退しきった内針411の係合ピン443が引っ掛かる角が基端側にあれば足りるため、図28に示す被係合部材444bのように、必ずしも山型形状に形成されていなくともよい。
In the fourth embodiment, the angled surface of the outer needle 410 that is parallel to the axial direction of the engaged member 444 shown in FIG. An engaged member 444a (see FIG. 27) having a further acute apex angle may be used. Then, the engagement pin 443 may be elastic so that it can get over the angled apex portion of the engaged member 444a when the inner needle 411 moves forward. Further, the engaged member of the outer needle 410 is engaged with the retracted inner needle 411 so that when the inner needle 411 is rotated in one direction, the rotation movement is transmitted by the engagement pin 443. Since it is sufficient that the angle at which the coupling pin 443 is caught is on the proximal end side, it is not always necessary to form the mountain shape like the engaged member 444b shown in FIG.
1,201,301 薬剤投与装置
2,402 穿刺針
3 把持部
4,204 チューブ
5,105,224 シリンジ
5a 雌ネジ
6 体表
7 臓器
8,225,325 プランジャ
8a 雄ネジ
10,10A,10C,410 外針
11,11A,11B,11C,411 内針
12,12a,12b,12c,412 第1のルーメン
13,13a,13b,13c,13d 開口
14 第2のルーメン
15 ストッパ
16 突起
17 ポンプ
18 レザバー
19 制御ユニット
106 係合部材
107 バネ
202 外筒
222 ベース部材
223 チャージグリップ
225a プッシャ
226 ガイド溝
227,229,443 係合ピン
228 カム溝
230 第1のバネ
231 第2のバネ
232 係合部材
233 第3のバネ
234,235 一方向弁
441 先端部
442 基端部
444,444a,444b 被係合部材
445 ストッパ 1,201,301 Drug administration device 2,402Puncture needle 3 Grasping part 4,204 Tube 5,105,224 Syringe 5a Female screw 6 Body surface 7 Organ 8,225,325 Plunger 8a Male screw 10,10A, 10C, 410 Outer needle 11, 11A, 11B, 11C, 411 Inner needle 12, 12a, 12b, 12c, 412 First lumen 13, 13a, 13b, 13c, 13d Opening 14 Second lumen 15 Stopper 16 Protrusion 17 Pump 18 Reservoir 19 Control unit 106 engagement member 107 spring 202 outer cylinder 222 base member 223 charge grip 225a pusher 226 guide groove 227, 229, 443 engagement pin 228 cam groove 230 first spring 231 second spring 232 engagement member 233 third Springs 234, 235 in one direction Valve 441 Tip portion 442 Base end portion 444, 444a, 444b Engaged member 445 Stopper
2,402 穿刺針
3 把持部
4,204 チューブ
5,105,224 シリンジ
5a 雌ネジ
6 体表
7 臓器
8,225,325 プランジャ
8a 雄ネジ
10,10A,10C,410 外針
11,11A,11B,11C,411 内針
12,12a,12b,12c,412 第1のルーメン
13,13a,13b,13c,13d 開口
14 第2のルーメン
15 ストッパ
16 突起
17 ポンプ
18 レザバー
19 制御ユニット
106 係合部材
107 バネ
202 外筒
222 ベース部材
223 チャージグリップ
225a プッシャ
226 ガイド溝
227,229,443 係合ピン
228 カム溝
230 第1のバネ
231 第2のバネ
232 係合部材
233 第3のバネ
234,235 一方向弁
441 先端部
442 基端部
444,444a,444b 被係合部材
445 ストッパ 1,201,301 Drug administration device 2,402
Claims (21)
- 生体組織に穿刺される穿刺針であって、
内部に第1のルーメンを有し、先端側の側面に前記第1のルーメンと連通する開口が設けられた外針と、
内部に第2のルーメンを有するとともに、少なくとも先端部が前記外針の前記第1のルーメンに進退運動可能に挿通された内針と、
を備え、
前記内針は、前記進退運動によって、前記外針の前記第1のルーメンに前記先端部が収容される第1の状態と、前記外針の前記開口から少なくとも前記先端部の一部が突出する第2の状態との間を遷移することを特徴とする穿刺針。 A puncture needle for puncturing a living tissue,
An outer needle having a first lumen therein and provided with an opening communicating with the first lumen on a side surface on a distal end side;
An inner needle having a second lumen therein and at least a distal end portion inserted through the first lumen of the outer needle so as to be capable of advancing and retracting;
With
The inner needle has a first state in which the distal end portion is accommodated in the first lumen of the outer needle and a part of the distal end portion protrudes from the opening of the outer needle by the forward and backward movement. A puncture needle characterized by transitioning between a second state. - 前記内針の先端は、前記外針の前記開口から突出したときに外側となる角が鋭角を成すことを特徴とする請求項1に記載の穿刺針。 The puncture needle according to claim 1, wherein the tip of the inner needle forms an acute angle when it protrudes from the opening of the outer needle.
- 前記内針は、前記外針の前記第1のルーメンに対して前進することによって、当該内針の前記先端部の一部が突出し、
前記外針は、前記内針の先端を前記第1のルーメンから前記開口に誘導するガイド面を、前記第1のルーメンに有することを特徴とする請求項1に記載の穿刺針。 The inner needle moves forward with respect to the first lumen of the outer needle, whereby a part of the tip portion of the inner needle protrudes,
The puncture needle according to claim 1, wherein the outer needle has a guide surface for guiding the tip of the inner needle from the first lumen to the opening in the first lumen. - 前記開口は、前記外針の側面に複数設けられることを特徴とする請求項1に記載の穿刺針。 The puncture needle according to claim 1, wherein a plurality of the openings are provided on a side surface of the outer needle.
- 前記複数の開口は、前記外針の長手方向における位置がそれぞれ異なることを特徴とする請求項4に記載の穿刺針。 The puncture needle according to claim 4, wherein the plurality of openings have different positions in the longitudinal direction of the outer needle.
- 前記内針は、前記複数の開口に対応して先端が分岐することを特徴とする請求項4に記載の穿刺針。 The puncture needle according to claim 4, wherein a tip of the inner needle branches corresponding to the plurality of openings.
- 前記外針は、前記内針の先端を前記第1のルーメンから前記開口に誘導するガイド面を、前記第1のルーメンに前記開口ごとに有し、
各ガイド面は、それぞれ異なる角度の傾斜を有することを特徴とする請求項4に記載の穿刺針。 The outer needle has a guide surface for guiding the tip of the inner needle from the first lumen to the opening for each opening in the first lumen;
The puncture needle according to claim 4, wherein each guide surface has an inclination of a different angle. - 前記外針の前記開口の軸方向を基端側に延伸する延長線上には、マーカが付されていることを特徴とする請求項1に記載の穿刺針。 The puncture needle according to claim 1, wherein a marker is attached on an extension line extending in the axial direction of the opening of the outer needle toward the proximal end side.
- 前記内針が前記第1の状態にあるときに、前記内針の運動と、前記外針の長手軸中心の回動運動とを連携させる連携機構をさらに備えたことを特徴とする請求項1に記載の穿刺針。 2. A cooperation mechanism for coordinating the movement of the inner needle and the rotational movement about the longitudinal axis of the outer needle when the inner needle is in the first state. The puncture needle as described in 2.
- 前記連携機構は、前記内針が前記第1の状態にあるときに、前記内針の進退運動によって前記外針の回転運動を生じさせる係合機構を含むことを特徴とする請求項9に記載の穿刺針。 The said cooperation mechanism contains the engagement mechanism which produces the rotational movement of the said outer needle by the advancing / retreating movement of the said inner needle, when the said inner needle exists in the said 1st state. Puncture needle.
- 前記係合機構は、係合ピンとカム溝を有し、前記係合ピンが前記カム溝に係合するものであることを特徴とする請求項10に記載の穿刺針。 The puncture needle according to claim 10, wherein the engagement mechanism includes an engagement pin and a cam groove, and the engagement pin is engaged with the cam groove.
- 前記カム溝は、軸方向に伸長する複数の直線溝と、各直線溝の基端と、各直線溝と隣り合う一方の前記直線溝の先端とをそれぞれ接続する溝であって前記複数の直線溝間を斜めに結ぶ複数の傾斜溝とによって形成されることを特徴とする請求項11に記載の穿刺針。 The cam groove is a groove that connects a plurality of linear grooves extending in the axial direction, a base end of each linear groove, and a tip of one of the linear grooves adjacent to each linear groove. The puncture needle according to claim 11, wherein the puncture needle is formed by a plurality of inclined grooves that obliquely connect the grooves.
- 前記係合ピンは、前記外針に接続するとともに前記内針の前進運動にしたがって前進する接続部材に設けられており、前記接続部材の前進により前記カム溝の前記傾斜溝を進行することによって前記外針を回転させることを特徴とする請求項12に記載の穿刺針。 The engaging pin is provided on a connecting member that is connected to the outer needle and advances in accordance with the forward movement of the inner needle, and the advancement of the connecting member advances the inclined groove of the cam groove. The puncture needle according to claim 12, wherein the outer needle is rotated.
- 前記外針を一定の方向に回動するように付勢する付勢機構をさらに有することを特徴とする請求項11に記載の穿刺針。 The puncture needle according to claim 11, further comprising a biasing mechanism that biases the outer needle to rotate in a certain direction.
- 前記連携機構は、前記内針が前記第1の状態にあるときに、前記内針の回転運動によって前記外針の回転運動を生じさせる係合機構を有することを特徴とする請求項9に記載の穿刺針。 The said cooperation mechanism has an engagement mechanism which produces the rotational motion of the said outer needle with the rotational motion of the said inner needle, when the said inner needle exists in the said 1st state. Puncture needle.
- 前記係合機構は、前記内針の外側面および前記外針の第1のルーメンの内側面のいずれか一方に設けられた係合ピンと、前記内針の外側面および外針の第1のルーメンの内側面の他方に設けられた被係合部材とを備え、
前記係合ピンと前記被係合部材とは、前記内針が前記第1の区間にあるときに係合する位置関係を有し、
前記係合ピンと前記被係合部材とが係合することによって、前記内針の回転運動が前記外針に伝達されて前記外針に回転運動が生じることを特徴とする請求項15に記載の穿刺針。 The engagement mechanism includes an engagement pin provided on one of the outer surface of the inner needle and the inner surface of the first lumen of the outer needle, and the outer surface of the inner needle and the first lumen of the outer needle. An engaged member provided on the other of the inner side surfaces of
The engaging pin and the engaged member have a positional relationship to engage when the inner needle is in the first section,
The rotational movement of the inner needle is transmitted to the outer needle and the rotational movement of the outer needle is generated by the engagement between the engagement pin and the engaged member. Puncture needle. - 前記外針は、基端部分と、前記開口及び前記連携機構が位置するとともに前記基端部分に対して当該外針の軸周りに回動自在である先端部分とを備え、
前記外針の前記先端部分は、前記連携機構によって前記基端部分に対して回動運動するように構成されていることを特徴とする請求項9に記載の穿刺針。 The outer needle includes a proximal end portion, and a distal end portion in which the opening and the cooperation mechanism are located, and a distal end portion that is rotatable around an axis of the outer needle with respect to the proximal end portion,
The puncture needle according to claim 9, wherein the distal end portion of the outer needle is configured to rotate with respect to the proximal end portion by the cooperation mechanism. - 前記内針は、基端においてシリンジポンプと接続しており、
前記シリンジポンプは、外面に雄ネジが形成されたプランジャと、内面に雌ネジが形成されたシリンジとを有することを特徴とする請求項1に記載の穿刺針。 The inner needle is connected to a syringe pump at the proximal end,
The puncture needle according to claim 1, wherein the syringe pump has a plunger having an external thread formed on an outer surface and a syringe having an internal thread formed on an inner surface. - 生体組織に穿刺される穿刺針と、前記穿刺針に薬剤を送出する薬剤送出ユニットを有する薬剤投与装置であって、
前記穿刺針は、内部に第1のルーメンを有し、先端側の側面に前記第1のルーメンと連通する開口が設けられた外針と、内部に第2のルーメンを有するとともに少なくとも先端部が前記外針の前記第1のルーメンに進退運動可能に挿通された内針とを備え、前記内針は、前記進退運動によって、前記外針の前記第1のルーメンに前記先端部が収容される第1の状態と、前記外針の前記開口から少なくとも前記先端部の一部が突出する第2の状態との間を遷移し、
前記薬剤送出ユニットは、前記薬剤を保持する保持部と、前記保持部に保持される前記薬剤を前記内針の前記第2のルーメンに送出する送出ポンプと、少なくとも前記内針が前記第2の状態であり、かつ、前記内針が前記外針に対して後退しているときに前記送出ポンプに薬剤送出のための圧力を印加させる制御部と、を備えたことを特徴とする薬剤投与装置。 A drug administration device having a puncture needle that is punctured into a biological tissue and a drug delivery unit that delivers the drug to the puncture needle,
The puncture needle has a first lumen inside, an outer needle provided with an opening communicating with the first lumen on a side surface on a tip side, a second lumen inside, and at least a tip portion. An inner needle inserted into the first lumen of the outer needle so as to be able to advance and retreat, and the distal end of the inner needle is accommodated in the first lumen of the outer needle by the advance and retreat movement. Transition between a first state and a second state in which at least a part of the tip portion protrudes from the opening of the outer needle,
The medicine delivery unit includes a holding part that holds the medicine, a delivery pump that delivers the medicine held in the holding part to the second lumen of the inner needle, and at least the inner needle includes the second needle. And a control unit that applies a pressure for drug delivery to the delivery pump when the inner needle is retracted relative to the outer needle. . - 外面に雄ネジが形成されたプランジャと、
内面に雌ネジが形成されたシリンジと、
を備えたことを特徴とするシリンジポンプ。 A plunger having an external thread formed on the outer surface;
A syringe with an internal thread formed on the inner surface;
A syringe pump characterized by comprising: - 前記プランジャに形成された前記雄ネジと、前記シリンジの内面に形成された前記雌ネジとの嵌合は、解除可能に構成されていることを特徴とする請求項20に記載のシリンジポンプ。 The syringe pump according to claim 20, wherein the fitting of the male screw formed on the plunger and the female screw formed on the inner surface of the syringe is configured to be releasable.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011-063373 | 2011-03-22 | ||
JP2011063373A JP2012196346A (en) | 2011-03-22 | 2011-03-22 | Puncture needle, medicine administration device and syringe pump |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012128129A1 true WO2012128129A1 (en) | 2012-09-27 |
Family
ID=46879281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2012/056456 WO2012128129A1 (en) | 2011-03-22 | 2012-03-13 | Puncturing needle, medicine administration apparatus, and syringe pump |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP2012196346A (en) |
WO (1) | WO2012128129A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023048230A1 (en) * | 2021-09-27 | 2023-03-30 | テルモ株式会社 | Therapy device kit |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015080692A (en) * | 2013-10-24 | 2015-04-27 | オリンパス株式会社 | Medical needle and medical instrument |
WO2022071080A1 (en) * | 2020-09-30 | 2022-04-07 | テルモ株式会社 | Medical instrument |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6159196A (en) * | 1998-03-09 | 2000-12-12 | Ruiz; Carlos | Methods and apparatus for transvascular muscular revascularization and drug delivery |
JP2001009033A (en) * | 1997-06-17 | 2001-01-16 | Novo Nordisk As | Injector having tiltable nut member |
JP2002507458A (en) * | 1998-03-25 | 2002-03-12 | トランスバスキュラー インコーポレイテッド | System and method for delivering a drug to a selected location in the body |
JP2004329485A (en) * | 2003-05-06 | 2004-11-25 | Asahi Intecc Co Ltd | Liquid medicine infusion device |
JP2005506101A (en) * | 2001-02-28 | 2005-03-03 | レックス メディカル リミテッド パートナーシップ | Device for supplying ablation fluid to treat neoplasm |
WO2009128393A1 (en) * | 2008-04-16 | 2009-10-22 | 株式会社バイオマスター | Syringe |
-
2011
- 2011-03-22 JP JP2011063373A patent/JP2012196346A/en not_active Withdrawn
-
2012
- 2012-03-13 WO PCT/JP2012/056456 patent/WO2012128129A1/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001009033A (en) * | 1997-06-17 | 2001-01-16 | Novo Nordisk As | Injector having tiltable nut member |
US6159196A (en) * | 1998-03-09 | 2000-12-12 | Ruiz; Carlos | Methods and apparatus for transvascular muscular revascularization and drug delivery |
JP2002507458A (en) * | 1998-03-25 | 2002-03-12 | トランスバスキュラー インコーポレイテッド | System and method for delivering a drug to a selected location in the body |
JP2005506101A (en) * | 2001-02-28 | 2005-03-03 | レックス メディカル リミテッド パートナーシップ | Device for supplying ablation fluid to treat neoplasm |
JP2004329485A (en) * | 2003-05-06 | 2004-11-25 | Asahi Intecc Co Ltd | Liquid medicine infusion device |
WO2009128393A1 (en) * | 2008-04-16 | 2009-10-22 | 株式会社バイオマスター | Syringe |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023048230A1 (en) * | 2021-09-27 | 2023-03-30 | テルモ株式会社 | Therapy device kit |
Also Published As
Publication number | Publication date |
---|---|
JP2012196346A (en) | 2012-10-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2491102C2 (en) | Device for injection of set dose of liquid preparation | |
JP4776686B2 (en) | Device comprising an insertion head and an inserter | |
JP6581194B2 (en) | Ocular implant delivery device and method | |
CN108883228B (en) | Liquid medicine administering device | |
JP3464220B2 (en) | Syringe and method of use | |
CN101687079B (en) | Automatic injection device | |
JP5991987B2 (en) | Automatic syringe | |
US9173997B2 (en) | External drug pump | |
EP2296743B1 (en) | Injection device | |
US20100114068A2 (en) | Autoflush Syringe Method | |
US20020188258A1 (en) | Hand-piece for injection device with a retractable and rotating needle | |
US7785298B2 (en) | Method and apparatus for co-injection | |
US10779807B2 (en) | Steerable sheath tube and method for occluding atrial septal defect | |
CA3104935A1 (en) | Syringe assembly | |
TW201026350A (en) | Drive assembly suitable for use in a medication delivery device and medication delivery device | |
WO2012128129A1 (en) | Puncturing needle, medicine administration apparatus, and syringe pump | |
KR20210048662A (en) | syringe | |
EP2806939A2 (en) | Microneedle adapter for dosed drug delivery devices | |
US20130041326A1 (en) | Injection apparatus for long distance delivery of soft tissue bulking agents containing microspheres | |
KR101733012B1 (en) | Micro needle device | |
RU2575549C2 (en) | Preset liquid drug dose injector (versions) | |
CN118215514A (en) | Vascular access device with effective needle length adjustment | |
JP2006180938A (en) | Injection needle for endoscope | |
WO2023138800A1 (en) | Auto injector with a separate distribution system | |
WO2010024807A1 (en) | Method and apparatus for co-injection |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 12760697 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 12760697 Country of ref document: EP Kind code of ref document: A1 |