WO2023138800A1 - Auto injector with a separate distribution system - Google Patents

Auto injector with a separate distribution system Download PDF

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Publication number
WO2023138800A1
WO2023138800A1 PCT/EP2022/073658 EP2022073658W WO2023138800A1 WO 2023138800 A1 WO2023138800 A1 WO 2023138800A1 EP 2022073658 W EP2022073658 W EP 2022073658W WO 2023138800 A1 WO2023138800 A1 WO 2023138800A1
Authority
WO
WIPO (PCT)
Prior art keywords
auto injector
push
spring
actuator
container
Prior art date
Application number
PCT/EP2022/073658
Other languages
French (fr)
Inventor
Claus Schmidt Møller
Jesper ROESTED
Original Assignee
Subcuject Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Subcuject Aps filed Critical Subcuject Aps
Publication of WO2023138800A1 publication Critical patent/WO2023138800A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1581—Right-angle needle-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/2474—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with movable piercing means, e.g. ampoule remains fixed or steady
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/314—Flat shaped barrel forms, e.g. credit card shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3265—Degree of extension of sleeve to its needle covering position is progressively established by the degree of piston insertion into the syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M2005/341—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub angularly adjustable or angled away from the axis of the injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means

Definitions

  • the invention relates to an auto injector with an actuator and a separate drug distribution system for subcutaneous injection of a therapeutic drug, wherein the drug distribution system provides a fluid pathway between a drug filled container and a hypodermic needle only when the auto injector is activated.
  • the objectives of the invention can be obtained by an auto injector with a separate drug distribution system, which is not connected with the drug filled container before activation, and which is capable of establishing a fluid communication between the container and a hypodermic needle being part of the drug distribution system when the auto injector is activated. Because of the separated container and drug distribution system the needle can be arranged perpendicular to the drug filled container without making the filling process of the container unnecessary complicated, and it is possible to make an auto injector, which during use is attached to the skin of the user, making the auto injector more stable in a situation of use.
  • the separate drug distribution system may further comprise a push button for establishing the fluid connection and for activating the auto injector.
  • the drug distribution system may be a sterile unit itself, whereby a terminal sterilization can be avoided.
  • the actuator comprises a fluid filled cylinder with a movable plunger, which is biased by a compressed spring, and which is fluidically communicating with the drug filled container, such that movement of the plunger in the cylinder forces fluid from the cylinder to the drug filled container where it presses on and moves the plunger in the container.
  • a locking mechanism is holding the spring until the auto injector is actuated, where after the spring starts moving the plunger in the cylinder, and the fluid is pressed from the cylinder to the drug filled container causing the plunger in the drug filled container to expel the drug.
  • a valve is arranged in the outlet end of the drug filled container.
  • the hypodermic needle fluidically connects with the drug filled container via the valve and a valve seat is pressed a distance into the container to open the valve. Pushing the push button also releases the spring and starts the injection.
  • the plunger in the drug filled container mates with the valve seat and moves it slightly in the closing direction of the valve, which in turn causes the hypodermic needle to be retracted from the injection site by means of a spring in the distribution system.
  • the spring is acting directly on the plunger in the drug filled container and a locking element is maintaining a spring retention element in a start position wherein the spring is compressed and ready for injection.
  • a cartridge needle is simply penetrating a septum on the drug filled container when a push-button is pushed, and when the plunger in the container reaches the opposite end of the container it simply pushes on the end of the cartridge needle and moves it slightly to cause the hypodermic needle to be retracted from the injection site by means of a spring in the distribution system.
  • the auto injector comprises: a container holding the pharmaceutical medicament, having a movable plunger and defining an axis, and an actuator for moving the plunger in the container by means of a push spring when the auto injector is activated, and a distribution system for distributing the drug comprising a connecting tube movable along the axis of the container, a push-button for activating the auto injector, an actuator starter, and a hypodermic needle for injection of the drug into the injection site, wherein the actuator starter during activation of the auto injector moves together with the push-button, thereby releasing the stored energy in the actuator, wherein the connecting tube during activation of the auto injector connects with both the hypodermic needle and the container to form a fluid path between the container and the injection site.
  • the spring is, before activation of the auto injector, retained in an initial compressed position by a spring tube, which is axially connected with a locking part with a non-circularly shaped end, the locking part is rotated to cause the non-circular shaped end to pass a restraining structure in the housing and thereby set the spring force free, and the spring is utilized to move a working fluid from the actuator to the container.
  • This is a simple way to turn around the force direction of the spring, and to hold the spring in a compressed state.
  • the locking part is essentially tube-formed and has a first internal thread or thread segment
  • a release part has a second external thread or thread segment engaging the first internal thread or thread segment and arranged such that non- rotational longitudinal movement of the release part will rotate the lock part enough to let the non-circularly end of the locking part pass the restraining structure in the housing.
  • the actuator starter is longitudinal and non-rotational moved by the push-button during the activation process, and this movement firstly engage with and rotational locks the release part and secondly pushes the release part long enough to allow the non-circularly shaped end of the locking part until it passes the restraining structure. This allows the actuator starter to be part of a separate distribution system.
  • a lock part with a slanted surface is arranged to be movable perpendicular to the axis of the container and to lock a spring tube in position, which thereby holds the spring in an initial compressed position, and a release part with a slanted surface cooperating with the slanted surface of the lock part is pushed by the actuator starter during activation of the auto injector, whereby the lock part is moved, and the spring tube and spring is released.
  • a mechanical advantage can be obtained in a simple way to ease the release of the spring.
  • the hypodermic needle is moved perpendicular to the axis of the container and proportional to the movement of the push-button, during activation of the auto injector. This makes it possible to let the needle come out of an opening on a big surface of the device, instead of in the end of the device, which again makes the device more stable during use.
  • a shield is hinged to the base plate, and when the auto injector is not yet placed on the injection site a part of the shield is protruding away from the base plate and a part is protruding into the auto injector blocking the push-button or an intermediate part from being moved in the push direction, and when the auto injector is placed on the injection site the shield is being aligned with the base plate whereby the pushbutton can be pushed, and when the auto injector is removed from the injection site a spring moves the shield back to the initial position, and the new position of the push-button or the intermediate part prevents the shield from being pushed in again to be aligned with the base plate.
  • An auto injector (100, 200) for subcutaneous injection of a pharmaceutical medicament comprising: a container (140, 240) holding the pharmaceutical medicament, having a movable plunger (146, 246) and defining an axis, and an actuator (120, 220) for moving the plunger (146, 246) in the container (140, 240) by means of a push spring (111 , 211) when the auto injector is activated, and a distribution system (160, 260) for distributing the drug, wherein the distribution system (160, 260) comprises: a connecting tube (166, 266) movable along the axis of the container (140, 240), a push-button (165, 265) for activating the auto injector, an actuator starter (161 , 261), and a hypodermic needle (168, 268) for injection of the drug into the injection site, wherein the actuator starter (161 , 261) during activation of the auto injector moves together with the push-button (165, 265), thereby releasing the actuator starter (16
  • the auto injector (100) for subcutaneous injection of a pharmaceutical medicament according to item 1 , wherein the spring (111) before activation of the auto injector (100, 200) is retained in an initial compressed position by a spring tube (112), which is axially connected with a locking part (108) with a non-circularly shaped end (109), wherein the locking part (108) is rotated to cause the non-circular shaped end (109) to pass a restraining structure (104) in the housing (118) and thereby set the spring force free, and wherein the spring (111) is utilized to move a working fluid (119) from the actuator (120) to the container (140).
  • the auto injector (100) for subcutaneous injection of a pharmaceutical medicament according to item 2, wherein the locking part (108) is essentially tube-formed and has a first internal thread (117) or thread segment, and wherein a release part (102) has a second external thread (106) or thread segment engaging the first internal thread (117) or thread segment, arranged such that non- rotational longitudinal movement of the release part (102) will rotate the lock part (108) to allow the non-circular end (109) of the locking part (108) to pass the restraining structure (104) in the housing (118).
  • the auto injector (200) for subcutaneous injection of a pharmaceutical medicament according to item 1 , wherein a lock part (202) with a slanted surface (217) and arranged to be movable perpendicular to the axis of the container (240) locks a spring tube (212) in position thereby holding the spring (211) in an initial compressed position, and wherein a release part (208) with a slanted surface (206) cooperating with the slanted surface (217) of the lock part (202) is pushed by the actuator starter (261) during activation of the auto injector (200), whereby the lock part (208) is moved, and the spring tube (212) and spring (211) is released.
  • the auto injector (200) for subcutaneous injection of a pharmaceutical medicament according to item 1 , wherein the hypodermic needle (268) is moved perpendicular to the axis of the container (240) and proportional to the movement of the push-button (265), during activation of the auto injector (200).
  • An auto injector (200) for subcutaneous injection of a pharmaceutical medicament wherein a shield (279) is hinged to the base plate (203), wherein when the auto injector (200) is not yet placed on the injection site a part of the shield (279) is protruding away from the base plate (203) and a part is protruding into the auto injector (200) blocking the push-button (265) or an intermediate part hereof from being moved in the push direction, wherein when the auto injector (200) is placed on the injection site the shield (279) is being aligned with the base plate (203) whereby the push-button can be pushed, and wherein when the auto injector (200) is removed from the injection site a spring (278) moves the shield (279) back to the initial position, and the new position of the pushbutton (265) or an intermediate part prevents the shield (279) from being pushed in to be aligned with the base plate (203).
  • Figure 1 shows a perspective view of an auto injector with a hydraulic actuator according to the invention
  • Figure 2 shows a perspective view of an auto injector with a hydraulic actuator according to the invention, where the outer cover has been removed
  • Figure 3 shows a side view of an auto injector with a hydraulic actuator according to the invention, where the outer cover has been removed, and where the push button has not been pushed
  • Figure 4 shows a side view of an auto injector with a hydraulic actuator according to the invention, where the outer cover has been removed, and where the push button has been pushed
  • Figure 5 shows an exploded view of an auto injector with a hydraulic actuator according to the invention
  • Figure 6 schematically shows a sectional view of an auto injector with a hydraulic actuator, where the outer cover has been removed, and where the push button has not yet been pushed
  • Figure 7 schematically shows a sectional view of an auto injector with a hydraulic actuator, where the outer cover has been removed, and where the push button has been pushed, but the plungers have not yet been moved
  • Figure 8 schematically shows a sectional view of an auto injector with a hydraulic actuator, where the outer cover has been removed, and where the push button has been pushed, and the plungers have moved, and the drug has been expelled
  • Figure 9 shows a perspective view of a spring driven auto injector according to the invention before attachment to the skin
  • Figure 10 shows a perspective view of a spring driven auto injector according to the invention after start of the device
  • Figure 11 shows an exploded view of a spring driven auto injector according to the invention
  • Figure 12 schematically shows a sectional view of a spring driven auto injector, where the outer cover has been removed, and where the push button has not yet been pushed
  • Figure 13 schematically shows a sectional view of a spring driven auto injector, where the outer cover has been removed, and where the push button has been pushed, but the plungers have not yet been moved
  • Figure 14 schematically shows a sectional view of a sp auto injector where the outer cover has been removed, and where the push button has been pushed, and the plungers have moved, and the drug has been expelled
  • Figure 15 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed, and before activation
  • Figure 16 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed and the release connector has been cut through, and before activation
  • Figure 17 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed and the release connector has been cut through, and after activation
  • Figure 18 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed and the release connector has been cut through, and after needle retraction
  • Parts, which are fixed together to form a functional unit acting as one part may be considered as being one part or may be divided in a different way, or the functional unit may form more or less parts, and this will still be within the scope of the invention.
  • drug filled container covers the use of all kind of vessels and containers from which the drug can be pressed out by means of a movable plunger, and all kind of cartridges and syringes in e.g. glass or polymer are therefore within the scope of the invention.
  • distributed system covers all mechanisms, which by actuation of the auto injector can distribute the drug from the drug filled container to the injection site. Multiple needle or catheter-based embodiments are thereby also within the scope of the invention.
  • drug drug
  • agent agent
  • medicament and “medicine” and with or without the prefix “pharmaceutical” are all to be understood as biologically or synthetic medicaments to be inserted in an individual to cure a disease for which the medicament is intended.
  • spring covers all forms of resilient materials and designs usable for the purpose.
  • Fig. 1 shows a perspective view of an auto injector 100. Visible are the housing 101 with a window 140 for displaying the content of the drug filled container.
  • the push button 165 which is part of the distribution system 160 (see fig. 2) is also visible and is (in fig.1 ) covered by a sterile barrier e.g. in the form of a flexible cover to keep the distribution system in a sterile condition (will be further explained).
  • a sterile barrier e.g. in the form of a flexible cover to keep the distribution system in a sterile condition (will be further explained).
  • the upper cover 101 of the auto injector 100 has been removed, and visible is now the distribution system 160 containing a hypodermic needle 168 (see fig. 4) to be inserted in the skin of the user, an actuator 120 and a drug filled container 140 with a valve 144.
  • the actuator is formed by a rigid cylinder with a working fluid and a plunger driven by a spring to drive the plunger in the drug filled container, but it may also be in the form of a flexible reservoir with a working fluid which is emptied by any kind of spring.
  • the valve 144 fluidically connects the cartridge 141 with the distribution system 160 and hypodermic needle 168 (see fig. 4) when the auto injector is actuated by a press on the push button 165. Also visible in fig. 2 are the bottom plate 103 and the connecting part 147 connecting the drug filled container 140 with the hydraulic actuator 120 (will be further explained).
  • the insertion of the needle 168 can be handled as a separate function independent of the driving mechanism of the auto injector 100. This also means that the needle can be inserted proportional to the movement of the push button, or that a spring designed only for this purpose can be used. In this way a more smooth and quiet insertion of the needle compared to state of the art is achieved.
  • Fig. 3 and 4 shows the interaction between the distribution system 160 and the drug filled container 140.
  • the auto injector is in a ready to use status, where the push button 165 has not been pushed, and a valve seat 150 (see fig. 5), which is part of the valve 144, is closing the outlet 142 of the glass cartridge 141.
  • the connecting tube 166 which is part of the distribution system 160, has not yet been moved into the valve 144 and consequently the container has not yet been connected with the distribution system 160.
  • the push button 165 has been pushed and a first end of the connecting tube 166 has connected with the valve 144 and pushed in the valve seat 150 to open the valve, and a second end of the connecting tube 166 has connected with a hypodermic needle 168, after this has been inserted in the subcutaneous tissue of the user during the activation, whereby a flow path from the container to the injection site has been established.
  • FIG. 6 shows an auto injector ready to be activated (with the housing 101 removed) wherein the drug filled container 140 with the valve 144 and the actuator 120 are sectioned so that the inner parts are displayed.
  • the outside of the plunger 146 in the drug filled container 140 and the actuator 120 are fluidically connected via the channel 148 in the cartridge connector 147.
  • the cartridge connector 147 is tightly secured to the cartridge 141 , and the cartridge, the valve 144 and the cartridge connector 147 can be preassembled and filled separately.
  • the actuator 120 is in the form of a cylinder formed by an upper and a lower half part 115, 118 permanently fixed together and comprising a working fluid 119, an actuator plunger 114 and a tensed spring 111 locked in position by a locking mechanism, which will be described in the following.
  • a spring tube 112 is biased against the actuator plunger 114 by the spring 111 and locked in position by a locking part 108.
  • the locking part 108 has a non-circular head 109 (see fig. 5), which can only pass through a non-circular hole 104 in the upper half part 118 at certain angular positions, and it is arranged such that passing through is prevented in the initial position.
  • a release part 102 is engaged with the lock part 108 via a thread connection 106, 117.
  • the push button 165 has been pushed, and this has caused the actuator starter 161 to penetrate the sterile barrier and move into the actuator 120.
  • the end 107 of the release part 102 is slotted and the end of the actuator starter 161 is shaped to match such that relative rotation between the release part 102 and the non- rotatable actuator starter 161 is not possible while the actuator starter 161 is pushing the release part 102, and the release part is thereby locked against rotation as it is pushed into the locking part 108.
  • the release part 102 will now rotate the locking part 108 until the head 109 is able to pass through the non-circular hole 104 in the upper half part 118 of the actuator 120, and the spring 111 is thereby set free to push and move the spring tube 112 and the actuator plunger 114. Furthermore, the needle 168 has been pushed through the sterile barrier and into the skin of the user, and the connecting tube 166 has connected with the drug filled container 140 by connecting with and pushing the valve body 151 and the valve seat 150 (fixed to the valve body 151) into the container 140, whereby a fluid connection between the drug filled container and the hypodermic needle 168 has been established.
  • Fig. 9 and 10 shows an embodiment 200 with a spring driven actuator 220 acting directly on the plunger in the drug filled container 240.
  • the drug filled container comprises a cartridge 241 with a plunger with a hard front e.g. a glass pin and a septum 244 instead of a valve.
  • the device 200 further comprises a distribution system 260 with a connecting tube 266 with a sharp end that penetrates the septum 244 during activation of the device 200.
  • the distribution system 260 further has a needle shield 279 that prevents that the push-button 265 can be pushed in before the device is placed on the skin of the user, and the shield further prevents needle injury if the device 200 should be removed from the skin before the hypodermic needle 268 has been retracted.
  • the device has not yet been positioned at the injection site, and it can be seen that the needle shield 279 is down and that the push-button 265 has not been pushed. Visible are the two housing parts 201a and 201 b forming a front and rear section of the housing, the needle shield 279, the push-button 265 and through the window in front house part 201 a the drug filled container 241 and the progress of the injection can be inspected.
  • Fig. 10 shows a situation of use where the needle shield 279 has been pushed up, the pushbutton 265 has been pushed in and the hypodermic needle 268 has been inserted.
  • FIG. 11 An exploded view of the device 200 can be seen in fig. 11 . Please refer to this to see features and/or parts, which may not be fully visible in the sectioned views. What can also be seen in the exploded view is, that the front housing part 201a together with all the distribution system parts is forming the distribution system 260.
  • the front housing part 201 a further forms the base plate 203, while the rear housing part 201 b houses the actuator 220 for moving the plunger 246 (see fig. 12) in the cartridge.
  • the distribution system 260 can be separately sterilized where after the drug filled container 241 can be added to the front housing part 201 a.
  • the actuator 220 is then placed on the base plate 203 and the rear housing 201 b containing the actuator 220 are snapped to the front housing 201a (snap features not shown).
  • the device 200 is not yet activated, and it is clear that the push-button 265 is not yet depressed.
  • the sharp end of the connecting tube 266, which is fixed to the push-button 265, has not yet penetrated the septum 244 on the cartridge 241 , and the blunt end 267 of the connecting tube 266 has not yet engaged with the inlet 274 of the hypodermic needle assembly 273 to form a fluid pathway from the drug filled container 201 to the injection site.
  • the locking part 208 can slide from right to left in the rear housing part 201 b guided by the ribs 293/294 and when forced by the release part 202.
  • the locking part 208 is in its initial position where it locks the spring 211 in a tensed start position, by means of the rib 204 in the slit 209 on the spring tube 212, and the spring 211 is tensed between the foot 213 on the spring tube 212 and the rib 293 in the rear housing 201 b.
  • the device has been placed with the base plate 203 over the intended injection site and it may be hold in place by means of an adhesive or other holding means or just by pressing it against the injection site with the hand.
  • the push-button 265 has been pushed and as the push-button is abutting the connector 269 and the connector and the actuator starter 261 are fixed together, these two parts have moved the same distance in the push direction.
  • the actuator starter 261 and thereby also the connector 269 are locked in this position by means of the snap feature 263 on the actuator starter 263 which is now protruding out through the opening 204 in the front housing part 201a.
  • the hypodermic needle assembly 273 comprises a hypodermic needle 268 and a needle inlet 274 and movement of the actuator starter 261 has caused the hypodermic needle assembly 273 to be pressed towards the injection site guided by the pin 277, whereby the hypodermic needle 268 has penetrated the skin at the injection site through an opening in the base plate 203 (not visible).
  • the sharp end of the connecting tube 266 has penetrated the septum 244 on the cartridge 241 and the blunt end 273 of the connecting tube 266 has moved into the inlet 274 of the hypodermic needle assembly 273, and a fluid path from the drug filled container 241 to the injection site has now been established (the function of the distribution system will be explained in details later).
  • the end face 264 of the actuator starter 261 is in contact with the release part 202 and the movement of the actuator starter 261 has caused the release part 202 to move the same distance. This has caused the slanted surface 206 on the locking part 208 to slide over the slanted surface 217 on the release part 202, so that the locking part 208 has been moved to the left, whereby the rib 204 on the locking part has been moved out of the slit 209 in the spring tube 212, and the spring 211 has expanded. This, in turn, has moved the plunger 246 in the drug filled container 241 and drug has been distributed through the distributing system 260 to the injecting site. The connecting tube 266 and the push-button 265 has not yet been moved in the opposite direction by the glass pin 247 in the plunger 246.
  • Fig. 14 shows the device in a state where the needle has been retracted.
  • the plunger/glass tip assembly 246/247 has pushed the connecting tube 266 and the push-button 265 a distance opposite to the activation direction that is clearly smaller than the activation distance, and the blunt end 267 of the connection tube 266 has been moved free of the inlet 274 on the hypodermic needle assembly 273.
  • the hypodermic needle assembly has been set free to move away from the injection site, and a torque spring 278 (see fig. 11) has retracted the hypodermic needle 268 and the needle assembly 273 to a hidden position inside the device 200.
  • the front housing 201 a which also forms the housing for the distribution system 260, has been left out to ease the visibility, and reference is made to fig. 11 and 12 to support the understanding of the front housing 201 a interaction with the parts of the distribution system 260.
  • Fig. 15 shows the distribution system 260 in a state where the push-button 265 has not yet been pushed.
  • the hypodermic needle assembly 273 is kept in an upper position by the double acting torque spring 278 (see fig. 11), where the hypodermic needle is hidden inside the distribution system 260.
  • the up/down movement of the needle assembly 273 is guided by the rib 277 on the bottom part 276, which is permanently fixed in an opening in the base plate 203 in the front housing 201 a.
  • Fig. 16-18 shows the same state and the following states but with the actuator starter 261 sectioned so that only the slanted rib 262 for moving down the hypodermic needle assembly 273 is visible.
  • fig. 16-18 reference is made to fig. 15 and the previous figures for details on the actuator starter 261 .
  • the device has been placed on the skin of the user whereby the shield 279 has been pushed up, and the protrusion 280 on the shield 279 has been flexed forward by the surface 272 on the connector 269. This has moved the locking feature 281 out of the cut-out 271 on the connector 269, and the push-button 265 has been pushed to activate the device 200.
  • the slanted rib 262 has slided over the slanted ramp 275 and pressed down the hypodermic needle assembly 273 guided by the rib 277, and in a second sequence the blunt end 267 of the connecting tube 266 has entered and tightly connected to the inlet 274 on the needle assembly 273 maintaining the needle assembly in the downward position with the hypodermic needle 268 inserted.
  • the sharp end of the connecting tube 266 has penetrated the septum 244 on the cartridge 241 (see fig. 14), and a fluid path between the drug filled container 240 and the injection site has been established.
  • the plunger/glass pin 246/247 in the container 241 has pushed on the sharp end of the connecting tube 266 and moved back the connecting tube 266 and the push-button 265 a small distance. This has moved the blunt end 267 of the connecting tube 266 out of the inlet 274 on the needle assembly 273.
  • the connector 269 is locked in the fully pushed position as it is permanently fixed to the actuator starter 261 , which is locked in position by the snap feature 263.
  • the slanted rib 262 does not move back to block upward movement of the hypodermic needle assembly 273, and this is consequently moved up to hide the hypodermic needle 268 inside the device 200 by the double acting torque spring 278.
  • the notch 270 on the connector 269 is now preventing the shield 279 from being pushed up again as the protrusion 280 has flexed in under the notch 270 and locked the shield 279 in the downward position.

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Abstract

The invention relates to an auto injector with a hydraulic actuator and a separate drug distribution system for subcutaneous injection of a therapeutic drug, wherein the drug distribution system provides a fluid pathway between a drug filled container and a hypodermic needle only when the auto injector is activated.

Description

AUTO INJECTOR WITH A SEPARATE DISTRIBUTION SYSTEM
Field of invention
The invention relates to an auto injector with an actuator and a separate drug distribution system for subcutaneous injection of a therapeutic drug, wherein the drug distribution system provides a fluid pathway between a drug filled container and a hypodermic needle only when the auto injector is activated.
Background
Through the last two decades the use of auto injectors for subcutaneous drug delivery has increased significantly every year as they allow patients to treat themselves at home. Automated needle insertion, injection and needle retraction or needle shielding is state of the art for pen shaped auto injectors and new auto injectors enters the market regularly. As users of auto injectors often are first-time users, it is essential that the auto injector is easy to use, smooth in operation and reliable, but this is not always the case.
For a first-time user the act of injection a medicament into his own body can be very stressful, and it is therefore very important that the auto injector is easy to understand and to handle, as the stressful situation can lead to an incorrect use of the auto injector with the risk of mistreatment.
To prevent that the injection is painful or unnecessarily scarring it is also important that the injection is carried out smoothly, with the correct injection speed and without accompaniment of high and scarring noises. Likewise, it is important that the auto injector is maintained in the same position throughout the injection, so that the inserted needle does not move or bend in the skin of the user with the risk of pain and bruises or a broken needle.
The most common problems with auto injectors are non-intuitive or awkward handling and complicated instructions, medicament expelled before the needle is inserted to the correct depth, too fast injection of the medicament, and loud noises when the auto injector shift from one functional sequence to another. Also malfunctions of the auto injector, especially related to the retraction of the needle, is rather common.
It is the objective of the invention to provide an auto injector, which is easy to maintain in the same position during the entire injection and which is small, simple and smooth in operation. Brief description of the invention
The objectives of the invention can be obtained by an auto injector with a separate drug distribution system, which is not connected with the drug filled container before activation, and which is capable of establishing a fluid communication between the container and a hypodermic needle being part of the drug distribution system when the auto injector is activated. Because of the separated container and drug distribution system the needle can be arranged perpendicular to the drug filled container without making the filling process of the container unnecessary complicated, and it is possible to make an auto injector, which during use is attached to the skin of the user, making the auto injector more stable in a situation of use.
The separate drug distribution system may further comprise a push button for establishing the fluid connection and for activating the auto injector. The drug distribution system may be a sterile unit itself, whereby a terminal sterilization can be avoided.
Beside the drug filled container a spring actuated actuator is arranged. The actuator comprises a fluid filled cylinder with a movable plunger, which is biased by a compressed spring, and which is fluidically communicating with the drug filled container, such that movement of the plunger in the cylinder forces fluid from the cylinder to the drug filled container where it presses on and moves the plunger in the container. A locking mechanism is holding the spring until the auto injector is actuated, where after the spring starts moving the plunger in the cylinder, and the fluid is pressed from the cylinder to the drug filled container causing the plunger in the drug filled container to expel the drug.
A valve is arranged in the outlet end of the drug filled container. When the push button in the drug distribution system is pressed, the hypodermic needle fluidically connects with the drug filled container via the valve and a valve seat is pressed a distance into the container to open the valve. Pushing the push button also releases the spring and starts the injection. In the end of the injection the plunger in the drug filled container mates with the valve seat and moves it slightly in the closing direction of the valve, which in turn causes the hypodermic needle to be retracted from the injection site by means of a spring in the distribution system.
In another embodiment the spring is acting directly on the plunger in the drug filled container and a locking element is maintaining a spring retention element in a start position wherein the spring is compressed and ready for injection. Hereby the hydraulic actuator is avoided, and a very simple injector can be made. In yet another embodiment a cartridge needle is simply penetrating a septum on the drug filled container when a push-button is pushed, and when the plunger in the container reaches the opposite end of the container it simply pushes on the end of the cartridge needle and moves it slightly to cause the hypodermic needle to be retracted from the injection site by means of a spring in the distribution system.
In more details the auto injector comprises: a container holding the pharmaceutical medicament, having a movable plunger and defining an axis, and an actuator for moving the plunger in the container by means of a push spring when the auto injector is activated, and a distribution system for distributing the drug comprising a connecting tube movable along the axis of the container, a push-button for activating the auto injector, an actuator starter, and a hypodermic needle for injection of the drug into the injection site, wherein the actuator starter during activation of the auto injector moves together with the push-button, thereby releasing the stored energy in the actuator, wherein the connecting tube during activation of the auto injector connects with both the hypodermic needle and the container to form a fluid path between the container and the injection site.
By letting an intermediate part connect with both the hypodermic needle and the drug filled container instead of just letting the hypodermic needle connect directly to the container, the needle and/or the container do not need to move to connect the two parts.
In one or more embodiments, the spring is, before activation of the auto injector, retained in an initial compressed position by a spring tube, which is axially connected with a locking part with a non-circularly shaped end, the locking part is rotated to cause the non-circular shaped end to pass a restraining structure in the housing and thereby set the spring force free, and the spring is utilized to move a working fluid from the actuator to the container. This is a simple way to turn around the force direction of the spring, and to hold the spring in a compressed state.
In one or more embodiments, the locking part is essentially tube-formed and has a first internal thread or thread segment, and a release part has a second external thread or thread segment engaging the first internal thread or thread segment and arranged such that non- rotational longitudinal movement of the release part will rotate the lock part enough to let the non-circularly end of the locking part pass the restraining structure in the housing. By this arrangement a linear movement arising from the activation of the auto injector can be used to activate the actuator.
In one or more embodiments, the actuator starter is longitudinal and non-rotational moved by the push-button during the activation process, and this movement firstly engage with and rotational locks the release part and secondly pushes the release part long enough to allow the non-circularly shaped end of the locking part until it passes the restraining structure. This allows the actuator starter to be part of a separate distribution system.
In one or more embodiments, a lock part with a slanted surface is arranged to be movable perpendicular to the axis of the container and to lock a spring tube in position, which thereby holds the spring in an initial compressed position, and a release part with a slanted surface cooperating with the slanted surface of the lock part is pushed by the actuator starter during activation of the auto injector, whereby the lock part is moved, and the spring tube and spring is released. Hereby a mechanical advantage can be obtained in a simple way to ease the release of the spring.
In one or more embodiments, the hypodermic needle is moved perpendicular to the axis of the container and proportional to the movement of the push-button, during activation of the auto injector. This makes it possible to let the needle come out of an opening on a big surface of the device, instead of in the end of the device, which again makes the device more stable during use.
In one or more embodiments, a shield is hinged to the base plate, and when the auto injector is not yet placed on the injection site a part of the shield is protruding away from the base plate and a part is protruding into the auto injector blocking the push-button or an intermediate part from being moved in the push direction, and when the auto injector is placed on the injection site the shield is being aligned with the base plate whereby the pushbutton can be pushed, and when the auto injector is removed from the injection site a spring moves the shield back to the initial position, and the new position of the push-button or the intermediate part prevents the shield from being pushed in again to be aligned with the base plate. In this way it is prevented that a user by accident activates the device before it has been attached to the skin of a user. Likewise, if the device is removed from the injection site before the needle has been retracted, or if the retraction of the needle fails, the shield will protect the user against needle injurie.
The invention will hereafter be described by way of the following non-limiting items.
1 . An auto injector (100, 200) for subcutaneous injection of a pharmaceutical medicament, comprising: a container (140, 240) holding the pharmaceutical medicament, having a movable plunger (146, 246) and defining an axis, and an actuator (120, 220) for moving the plunger (146, 246) in the container (140, 240) by means of a push spring (111 , 211) when the auto injector is activated, and a distribution system (160, 260) for distributing the drug, wherein the distribution system (160, 260) comprises: a connecting tube (166, 266) movable along the axis of the container (140, 240), a push-button (165, 265) for activating the auto injector, an actuator starter (161 , 261), and a hypodermic needle (168, 268) for injection of the drug into the injection site, wherein the actuator starter (161 , 261) during activation of the auto injector moves together with the push-button (165, 265), thereby releasing the stored energy in the actuator (120, 220), and wherein the connecting tube (166, 266) during activation of the auto injector (100, 200) connects with both the hypodermic needle (168, 268) and the container (140, 240) to form a fluid path between the container (140, 240) and the injection site.
2. The auto injector (100) for subcutaneous injection of a pharmaceutical medicament according to item 1 , wherein the spring (111) before activation of the auto injector (100, 200) is retained in an initial compressed position by a spring tube (112), which is axially connected with a locking part (108) with a non-circularly shaped end (109), wherein the locking part (108) is rotated to cause the non-circular shaped end (109) to pass a restraining structure (104) in the housing (118) and thereby set the spring force free, and wherein the spring (111) is utilized to move a working fluid (119) from the actuator (120) to the container (140).
3. The auto injector (100) for subcutaneous injection of a pharmaceutical medicament according to item 2, wherein the locking part (108) is essentially tube-formed and has a first internal thread (117) or thread segment, and wherein a release part (102) has a second external thread (106) or thread segment engaging the first internal thread (117) or thread segment, arranged such that non- rotational longitudinal movement of the release part (102) will rotate the lock part (108) to allow the non-circular end (109) of the locking part (108) to pass the restraining structure (104) in the housing (118).
4. The auto injector (100) for subcutaneous injection of a pharmaceutical medicament according to item 3, wherein the actuator starter (161) is longitudinally and non-rotationally moved by the push-button (165) during the activation process, and wherein the actuator starter (161) during this movement firstly engage with and rotational locks to the release part (102) and secondly pushes the release part long enough to rotate the non-circular shaped end (109) of the locking part (108) until it passes the restraining structure (104).
5. The auto injector (200) for subcutaneous injection of a pharmaceutical medicament according to item 1 , wherein a lock part (202) with a slanted surface (217) and arranged to be movable perpendicular to the axis of the container (240) locks a spring tube (212) in position thereby holding the spring (211) in an initial compressed position, and wherein a release part (208) with a slanted surface (206) cooperating with the slanted surface (217) of the lock part (202) is pushed by the actuator starter (261) during activation of the auto injector (200), whereby the lock part (208) is moved, and the spring tube (212) and spring (211) is released.
6. The auto injector (200) for subcutaneous injection of a pharmaceutical medicament according to item 1 , wherein the hypodermic needle (268) is moved perpendicular to the axis of the container (240) and proportional to the movement of the push-button (265), during activation of the auto injector (200).
7. An auto injector (200) for subcutaneous injection of a pharmaceutical medicament according to item 6, wherein a shield (279) is hinged to the base plate (203), wherein when the auto injector (200) is not yet placed on the injection site a part of the shield (279) is protruding away from the base plate (203) and a part is protruding into the auto injector (200) blocking the push-button (265) or an intermediate part hereof from being moved in the push direction, wherein when the auto injector (200) is placed on the injection site the shield (279) is being aligned with the base plate (203) whereby the push-button can be pushed, and wherein when the auto injector (200) is removed from the injection site a spring (278) moves the shield (279) back to the initial position, and the new position of the pushbutton (265) or an intermediate part prevents the shield (279) from being pushed in to be aligned with the base plate (203).
When describing the embodiments, the combinations and permutations of all possible embodiments have not been explicitly described. Nevertheless, the mere fact that certain measures are recited in mutually different dependent claims or described in different embodiments does not indicate that a combination of these measures cannot be used to advantage. The present invention envisages all possible combinations and permutations of the described embodiments.
Figures
In the following the invention is described in further details with reference to the drawings, wherein Figure 1 shows a perspective view of an auto injector with a hydraulic actuator according to the invention
Figure 2 shows a perspective view of an auto injector with a hydraulic actuator according to the invention, where the outer cover has been removed
Figure 3 shows a side view of an auto injector with a hydraulic actuator according to the invention, where the outer cover has been removed, and where the push button has not been pushed
Figure 4 shows a side view of an auto injector with a hydraulic actuator according to the invention, where the outer cover has been removed, and where the push button has been pushed
Figure 5 shows an exploded view of an auto injector with a hydraulic actuator according to the invention
Figure 6 schematically shows a sectional view of an auto injector with a hydraulic actuator, where the outer cover has been removed, and where the push button has not yet been pushed
Figure 7 schematically shows a sectional view of an auto injector with a hydraulic actuator, where the outer cover has been removed, and where the push button has been pushed, but the plungers have not yet been moved
Figure 8 schematically shows a sectional view of an auto injector with a hydraulic actuator, where the outer cover has been removed, and where the push button has been pushed, and the plungers have moved, and the drug has been expelled
Figure 9 shows a perspective view of a spring driven auto injector according to the invention before attachment to the skin
Figure 10 shows a perspective view of a spring driven auto injector according to the invention after start of the device Figure 11 shows an exploded view of a spring driven auto injector according to the invention
Figure 12 schematically shows a sectional view of a spring driven auto injector, where the outer cover has been removed, and where the push button has not yet been pushed
Figure 13 schematically shows a sectional view of a spring driven auto injector, where the outer cover has been removed, and where the push button has been pushed, but the plungers have not yet been moved
Figure 14 schematically shows a sectional view of a sp auto injector where the outer cover has been removed, and where the push button has been pushed, and the plungers have moved, and the drug has been expelled
Figure 15 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed, and before activation
Figure 16 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed and the release connector has been cut through, and before activation
Figure 17 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed and the release connector has been cut through, and after activation
Figure 18 shows a perspective view of a distribution system for an auto injector according to the invention, where the outer cover has been removed and the release connector has been cut through, and after needle retraction
Detailed description
Various examples are described hereinafter with reference to the figures. It should also be noted that the figures are only intended to facilitate the description of the examples. They are not intended as an exhaustive description of the claimed invention or as a limitation on the scope of the claimed invention. In addition, an illustrated example needs not have all the aspects or advantages shown. An aspect or an advantage described in conjunction with a particular example is not necessarily limited to that example and can be practiced in any other examples even if not so illustrated, or if not so explicitly described.
In the following the terms “up” and “down”, “upper” and “lower”, “upward” and “downward” and “left” and “right” refer to the drawings and does not necessarily correspond to a situation of use.
Parts, which are fixed together to form a functional unit acting as one part, may be considered as being one part or may be divided in a different way, or the functional unit may form more or less parts, and this will still be within the scope of the invention.
The terms “drug filled container”, “container unit” and “cartridge” covers the use of all kind of vessels and containers from which the drug can be pressed out by means of a movable plunger, and all kind of cartridges and syringes in e.g. glass or polymer are therefore within the scope of the invention.
The term “distribution system” covers all mechanisms, which by actuation of the auto injector can distribute the drug from the drug filled container to the injection site. Multiple needle or catheter-based embodiments are thereby also within the scope of the invention.
The terms “drug”, “agent”, “medicament” and “medicine” and with or without the prefix “pharmaceutical” are all to be understood as biologically or synthetic medicaments to be inserted in an individual to cure a disease for which the medicament is intended.
The term “spring” covers all forms of resilient materials and designs usable for the purpose.
Fig. 1 shows a perspective view of an auto injector 100. Visible are the housing 101 with a window 140 for displaying the content of the drug filled container. The push button 165, which is part of the distribution system 160 (see fig. 2) is also visible and is (in fig.1 ) covered by a sterile barrier e.g. in the form of a flexible cover to keep the distribution system in a sterile condition (will be further explained). In fig. 2 the upper cover 101 of the auto injector 100 has been removed, and visible is now the distribution system 160 containing a hypodermic needle 168 (see fig. 4) to be inserted in the skin of the user, an actuator 120 and a drug filled container 140 with a valve 144.
In the shown embodiment the actuator is formed by a rigid cylinder with a working fluid and a plunger driven by a spring to drive the plunger in the drug filled container, but it may also be in the form of a flexible reservoir with a working fluid which is emptied by any kind of spring.
The valve 144 fluidically connects the cartridge 141 with the distribution system 160 and hypodermic needle 168 (see fig. 4) when the auto injector is actuated by a press on the push button 165. Also visible in fig. 2 are the bottom plate 103 and the connecting part 147 connecting the drug filled container 140 with the hydraulic actuator 120 (will be further explained).
During the injection the lower side of the bottom plate 103 is pressed against the skin of the user at the position for the desired injection, and after activation the hypodermic needle 168 penetrates through an opening in the bottom plate 103 perpendicular to the drug filled container 140. This makes it considerable easier to avoid moving the auto injector with the needle in the skin, and needles which are bended or broken during insertion in the skin is avoided. The device may also be attached to the user by means of an adhesive on the bottom plate.
Because the distribution system 160 is a separate unit, the insertion of the needle 168 can be handled as a separate function independent of the driving mechanism of the auto injector 100. This also means that the needle can be inserted proportional to the movement of the push button, or that a spring designed only for this purpose can be used. In this way a more smooth and quiet insertion of the needle compared to state of the art is achieved.
Fig. 3 and 4 shows the interaction between the distribution system 160 and the drug filled container 140. In fig. 3 the auto injector is in a ready to use status, where the push button 165 has not been pushed, and a valve seat 150 (see fig. 5), which is part of the valve 144, is closing the outlet 142 of the glass cartridge 141. The connecting tube 166, which is part of the distribution system 160, has not yet been moved into the valve 144 and consequently the container has not yet been connected with the distribution system 160. In fig. 4 the push button 165 has been pushed and a first end of the connecting tube 166 has connected with the valve 144 and pushed in the valve seat 150 to open the valve, and a second end of the connecting tube 166 has connected with a hypodermic needle 168, after this has been inserted in the subcutaneous tissue of the user during the activation, whereby a flow path from the container to the injection site has been established.
An exploded view of the auto injector spreading the main components (the housing 101 , the actuator 120, the drug filled container 140 with the valve 144, the distribution system 160 and the bottom plate 103) and fully exploding the actuator 120 can be seen in fig. 5, and this may be referred to when the geometry or position of a component is unclear during the explanation of the function in the following sectioned figures.
In the following fig. 6 - 8 the functional sequences of the auto injector and especially the actuator will be described. Fig. 6 shows an auto injector ready to be activated (with the housing 101 removed) wherein the drug filled container 140 with the valve 144 and the actuator 120 are sectioned so that the inner parts are displayed. As can be seen on the figure the outside of the plunger 146 in the drug filled container 140 and the actuator 120 are fluidically connected via the channel 148 in the cartridge connector 147. The cartridge connector 147 is tightly secured to the cartridge 141 , and the cartridge, the valve 144 and the cartridge connector 147 can be preassembled and filled separately.
The actuator 120 is in the form of a cylinder formed by an upper and a lower half part 115, 118 permanently fixed together and comprising a working fluid 119, an actuator plunger 114 and a tensed spring 111 locked in position by a locking mechanism, which will be described in the following. A spring tube 112 is biased against the actuator plunger 114 by the spring 111 and locked in position by a locking part 108. The locking part 108 has a non-circular head 109 (see fig. 5), which can only pass through a non-circular hole 104 in the upper half part 118 at certain angular positions, and it is arranged such that passing through is prevented in the initial position. A release part 102 is engaged with the lock part 108 via a thread connection 106, 117. In fig. 7 the push button 165 has been pushed, and this has caused the actuator starter 161 to penetrate the sterile barrier and move into the actuator 120. The end 107 of the release part 102 is slotted and the end of the actuator starter 161 is shaped to match such that relative rotation between the release part 102 and the non- rotatable actuator starter 161 is not possible while the actuator starter 161 is pushing the release part 102, and the release part is thereby locked against rotation as it is pushed into the locking part 108. Because of the thread connection 106, 117 the release part 102 will now rotate the locking part 108 until the head 109 is able to pass through the non-circular hole 104 in the upper half part 118 of the actuator 120, and the spring 111 is thereby set free to push and move the spring tube 112 and the actuator plunger 114. Furthermore, the needle 168 has been pushed through the sterile barrier and into the skin of the user, and the connecting tube 166 has connected with the drug filled container 140 by connecting with and pushing the valve body 151 and the valve seat 150 (fixed to the valve body 151) into the container 140, whereby a fluid connection between the drug filled container and the hypodermic needle 168 has been established. Due to the working fluid connection between the actuator 120 and the outside surface of the plunger 146 via the connector 148, the movement of the spring tube 112 due to the push by the spring 111 , will now cause the working fluid 119 to move from the actuator 120 to the drug filled container 120 causing the cartridge plunger 146 to move and the drug to be pushed through the distribution system 160 and out of the hypodermic needle 168.
In fig. 8 most of the working fluid 119 has been pushed from the actuator 120 to the container 140, which in turn has pushed the plunger 146 and injected the drug through the distribution system 160 and the hypodermic needle 168. In the end of the injection the plunger 146 has interacted with the valve seat 150 and pushed the valve seat 150, the valve body 151 and the connecting tube 166 and push button 165 a distance opposite to the push direction of the push-button, and this has in turn caused the hypodermic needle to be retracted by means of a spring in the distribution system 160 (not showed).
Fig. 9 and 10 shows an embodiment 200 with a spring driven actuator 220 acting directly on the plunger in the drug filled container 240. The drug filled container comprises a cartridge 241 with a plunger with a hard front e.g. a glass pin and a septum 244 instead of a valve. The device 200 further comprises a distribution system 260 with a connecting tube 266 with a sharp end that penetrates the septum 244 during activation of the device 200. The distribution system 260 further has a needle shield 279 that prevents that the push-button 265 can be pushed in before the device is placed on the skin of the user, and the shield further prevents needle injury if the device 200 should be removed from the skin before the hypodermic needle 268 has been retracted.
In fig. 9 the device has not yet been positioned at the injection site, and it can be seen that the needle shield 279 is down and that the push-button 265 has not been pushed. Visible are the two housing parts 201a and 201 b forming a front and rear section of the housing, the needle shield 279, the push-button 265 and through the window in front house part 201 a the drug filled container 241 and the progress of the injection can be inspected.
Fig. 10 shows a situation of use where the needle shield 279 has been pushed up, the pushbutton 265 has been pushed in and the hypodermic needle 268 has been inserted.
An exploded view of the device 200 can be seen in fig. 11 . Please refer to this to see features and/or parts, which may not be fully visible in the sectioned views. What can also be seen in the exploded view is, that the front housing part 201a together with all the distribution system parts is forming the distribution system 260. The front housing part 201 a further forms the base plate 203, while the rear housing part 201 b houses the actuator 220 for moving the plunger 246 (see fig. 12) in the cartridge. The distribution system 260 can be separately sterilized where after the drug filled container 241 can be added to the front housing part 201 a. To fully assemble the device 200 the actuator 220 is then placed on the base plate 203 and the rear housing 201 b containing the actuator 220 are snapped to the front housing 201a (snap features not shown).
In fig. 12-14 the functional steps of the embodiment will be described in further details. In fig. 9 the device 200 is not yet activated, and it is clear that the push-button 265 is not yet depressed. The sharp end of the connecting tube 266, which is fixed to the push-button 265, has not yet penetrated the septum 244 on the cartridge 241 , and the blunt end 267 of the connecting tube 266 has not yet engaged with the inlet 274 of the hypodermic needle assembly 273 to form a fluid pathway from the drug filled container 201 to the injection site. The locking part 208 can slide from right to left in the rear housing part 201 b guided by the ribs 293/294 and when forced by the release part 202. In fig. 12 the locking part 208 is in its initial position where it locks the spring 211 in a tensed start position, by means of the rib 204 in the slit 209 on the spring tube 212, and the spring 211 is tensed between the foot 213 on the spring tube 212 and the rib 293 in the rear housing 201 b.
In fig. 13 the device has been placed with the base plate 203 over the intended injection site and it may be hold in place by means of an adhesive or other holding means or just by pressing it against the injection site with the hand. The push-button 265 has been pushed and as the push-button is abutting the connector 269 and the connector and the actuator starter 261 are fixed together, these two parts have moved the same distance in the push direction. Hereafter the actuator starter 261 and thereby also the connector 269 are locked in this position by means of the snap feature 263 on the actuator starter 263 which is now protruding out through the opening 204 in the front housing part 201a. The hypodermic needle assembly 273 comprises a hypodermic needle 268 and a needle inlet 274 and movement of the actuator starter 261 has caused the hypodermic needle assembly 273 to be pressed towards the injection site guided by the pin 277, whereby the hypodermic needle 268 has penetrated the skin at the injection site through an opening in the base plate 203 (not visible). The sharp end of the connecting tube 266 has penetrated the septum 244 on the cartridge 241 and the blunt end 273 of the connecting tube 266 has moved into the inlet 274 of the hypodermic needle assembly 273, and a fluid path from the drug filled container 241 to the injection site has now been established (the function of the distribution system will be explained in details later). The end face 264 of the actuator starter 261 is in contact with the release part 202 and the movement of the actuator starter 261 has caused the release part 202 to move the same distance. This has caused the slanted surface 206 on the locking part 208 to slide over the slanted surface 217 on the release part 202, so that the locking part 208 has been moved to the left, whereby the rib 204 on the locking part has been moved out of the slit 209 in the spring tube 212, and the spring 211 has expanded. This, in turn, has moved the plunger 246 in the drug filled container 241 and drug has been distributed through the distributing system 260 to the injecting site. The connecting tube 266 and the push-button 265 has not yet been moved in the opposite direction by the glass pin 247 in the plunger 246.
Fig. 14 shows the device in a state where the needle has been retracted. The plunger/glass tip assembly 246/247 has pushed the connecting tube 266 and the push-button 265 a distance opposite to the activation direction that is clearly smaller than the activation distance, and the blunt end 267 of the connection tube 266 has been moved free of the inlet 274 on the hypodermic needle assembly 273. Thus, the hypodermic needle assembly has been set free to move away from the injection site, and a torque spring 278 (see fig. 11) has retracted the hypodermic needle 268 and the needle assembly 273 to a hidden position inside the device 200.
In fig. 15-18 the function of the distribution system 260 will be explained in detail. The front housing 201 a, which also forms the housing for the distribution system 260, has been left out to ease the visibility, and reference is made to fig. 11 and 12 to support the understanding of the front housing 201 a interaction with the parts of the distribution system 260.
Fig. 15 shows the distribution system 260 in a state where the push-button 265 has not yet been pushed. The hypodermic needle assembly 273 is kept in an upper position by the double acting torque spring 278 (see fig. 11), where the hypodermic needle is hidden inside the distribution system 260. The up/down movement of the needle assembly 273 is guided by the rib 277 on the bottom part 276, which is permanently fixed in an opening in the base plate 203 in the front housing 201 a. Fig. 16-18 shows the same state and the following states but with the actuator starter 261 sectioned so that only the slanted rib 262 for moving down the hypodermic needle assembly 273 is visible. For fig. 16-18 reference is made to fig. 15 and the previous figures for details on the actuator starter 261 .
In fig. 16 it can be seen that the slanted rib 262 is lying on the slanted ramp 275 ready to move the needle assembly 273 downwards when the push-button 265 is pushed. The blunt end 267 of the connection tube 266 is not yet engaged with the inlet 274 on the needle assembly 273. As the device has not yet been placed on the skin of the user the shield 279 is in its downward position biased by the double acting torque spring 278 (not shown, please see fig. 11). The locking feature 281 on the shield 279 is positioned in the cut-out 271 on the connector 269, and consequently it is not possible to push the push-button 265. In fig. 17 the device has been placed on the skin of the user whereby the shield 279 has been pushed up, and the protrusion 280 on the shield 279 has been flexed forward by the surface 272 on the connector 269. This has moved the locking feature 281 out of the cut-out 271 on the connector 269, and the push-button 265 has been pushed to activate the device 200. In a first sequence the slanted rib 262 has slided over the slanted ramp 275 and pressed down the hypodermic needle assembly 273 guided by the rib 277, and in a second sequence the blunt end 267 of the connecting tube 266 has entered and tightly connected to the inlet 274 on the needle assembly 273 maintaining the needle assembly in the downward position with the hypodermic needle 268 inserted. The sharp end of the connecting tube 266 has penetrated the septum 244 on the cartridge 241 (see fig. 14), and a fluid path between the drug filled container 240 and the injection site has been established.
In fig. 18 the plunger/glass pin 246/247 in the container 241 has pushed on the sharp end of the connecting tube 266 and moved back the connecting tube 266 and the push-button 265 a small distance. This has moved the blunt end 267 of the connecting tube 266 out of the inlet 274 on the needle assembly 273. The connector 269 is locked in the fully pushed position as it is permanently fixed to the actuator starter 261 , which is locked in position by the snap feature 263. As the actuator starter 261 stays in the fully pushed position, the slanted rib 262 does not move back to block upward movement of the hypodermic needle assembly 273, and this is consequently moved up to hide the hypodermic needle 268 inside the device 200 by the double acting torque spring 278. The notch 270 on the connector 269 is now preventing the shield 279 from being pushed up again as the protrusion 280 has flexed in under the notch 270 and locked the shield 279 in the downward position.

Claims

Claims
1 . An auto injector (100, 200) for subcutaneous injection of a pharmaceutical medicament, the auto injector comprising: a container (140, 240) suitable for holding the pharmaceutical medicament, the container having a movable plunger (146, 246) and a longitudinal axis extending along and through the container (140, 240); an actuator (120, 220), wherein the actuator is configured for moving the plunger (146, 246) comprised in the container (140, 240) when the auto injector is activated, wherein the plunger is moved by means of stored energy in the form of a push spring (111 , 211); and a distribution system (160, 260) configured for distributing the pharmaceutical medicament, wherein the distribution system (160, 260) comprises: a connecting tube (166, 266) movable along the longitudinal axis of the container (140, 240); a push-button (165, 265) configured for activating the auto injector; an actuator starter (161 , 261); and a hypodermic needle (168, 268) configured for subcutaneous injection of the pharmaceutical medicament into an injection site, wherein the actuator starter (161 , 261) is configured to release the stored energy in the actuator (120, 220) during activation of the auto injector, such that the actuator (120, 220) moves together with the push-button (165, 265), and wherein the connecting tube (166, 266) is configured for connecting with both the hypodermic needle (168, 268) and the container (140, 240) to form a fluid path between the container (140, 240) and the injection site during activation of the auto injector (100, 200).
2. The auto injector (100) according to claim 1 , further comprising a spring tube (112), a locking part (108) having a non-circularly shaped end (109), and a restraining structure (104); wherein the push spring (111) is retained in an initial compressed position by the spring tube (112) prior to activation of the auto injector (100, 200), wherein the initial compressed position is axially connected with the locking part (108), wherein the locking part (108) is configured to be rotated to cause the non-circular shaped end (109) to pass the restraining structure (104) thereby releasing the stored energy, and wherein the push spring (111) is further configured to move a working fluid (119) from the actuator (120) to the container (140). The auto injector (100) according to claim 2, further comprising a release part (102) and wherein the locking part (108) is essentially tube-formed and has a first internal thread (117) or thread segment and the release part (102) has a second external thread (106) or thread segment engaging the first internal thread (117) or thread segment and arranged such that non-rotational longitudinal movement of the release part (102) will rotate the lock part (108) to allow the non-circular end (109) of the locking part (108) to pass the restraining structure (104). The auto injector (100) according to claim 3, wherein the actuator starter (161) is configured to be moved non-rotationally and in a longitudinally direction of the auto injector (100) by the push-button (165) during the activation process, and wherein the actuator starter (161) during this movement is configure to firstly engage with and rotational lock to the release part (102) and secondly push the release part to rotate the non-circular shaped end (109) of the locking part (108) until it passes the restraining structure (104). The auto injector (200) according to claim 1 , further comprising a lock part (202) with a slanted surface (217), a spring tube (212), and a release part (208) with a slanted surface (206); wherein the lock part (202) is arranged to be movable perpendicular to the longitudinal axis of the container (240), and wherein the lock part (202) locks the spring tube (212) in a first position thereby holding the push spring (211) in an initial compressed position, and wherein the release part (208) is engaging with the slanted surface (217) of the lock part (202), and wherein the release part (208) is configured to be pushed by the actuator starter (261) during activation of the auto injector (200) such that the lock part (208) is moved and the spring tube (212) and push spring (211) is released. The auto injector (200) according to any of the preceding claims, wherein the hypodermic needle (268) is configured to be moved perpendicular to the longitudinal axis of the container (240) and proportional to the movement of the push-button (265) during activation of the auto injector (200). The auto injector (200) according to claim 6, further comprising a base plate (203), a spring (278), and a shield (279) hinged to the base plate (203), wherein the shield (279) is configured such that: prior to placing the auto injector (200) on the injection site a first part of the shield (279) is protruding away from the base plate (203) and a second part of the shield (279) is protruding into the auto injector (200) hereby blocking the push-button (265) or an intermediate part of the push-button (265) from being moved in a push direction; when the auto injector (200) is placed on the injection site the shield (279) is being aligned with the base plate (203) whereby the push-button can be pushed; and when the auto injector (200) is removed from the injection site, the spring (278) moves the shield (279) back to the initial position, and the new position of the push-button (265) or an intermediate part thereof prevents the shield (279) from being pushed in to be aligned with the base plate (203).
PCT/EP2022/073658 2022-01-19 2022-08-25 Auto injector with a separate distribution system WO2023138800A1 (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120022499A1 (en) * 2010-04-21 2012-01-26 Abbott Biotechnology Ltd. Wearable automatic injection device for controlled delivery of therapeutic agents
US20190091404A1 (en) * 2017-09-25 2019-03-28 Insulet Corporation Pre-filled cartridge-based drug delivery device
WO2020255105A1 (en) * 2019-06-21 2020-12-24 Preci Health Sa Medical injection system and method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120022499A1 (en) * 2010-04-21 2012-01-26 Abbott Biotechnology Ltd. Wearable automatic injection device for controlled delivery of therapeutic agents
US20190091404A1 (en) * 2017-09-25 2019-03-28 Insulet Corporation Pre-filled cartridge-based drug delivery device
WO2020255105A1 (en) * 2019-06-21 2020-12-24 Preci Health Sa Medical injection system and method

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