WO2012084390A1 - Polyamide/polyvinyl pyrrolidone (pa/pvp) polymer mixtures as a catheter material - Google Patents
Polyamide/polyvinyl pyrrolidone (pa/pvp) polymer mixtures as a catheter material Download PDFInfo
- Publication number
- WO2012084390A1 WO2012084390A1 PCT/EP2011/070814 EP2011070814W WO2012084390A1 WO 2012084390 A1 WO2012084390 A1 WO 2012084390A1 EP 2011070814 W EP2011070814 W EP 2011070814W WO 2012084390 A1 WO2012084390 A1 WO 2012084390A1
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- WO
- WIPO (PCT)
- Prior art keywords
- balloon
- pvp
- catheter
- polyamide
- polymer mixture
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L29/126—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/049—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T428/1393—Multilayer [continuous layer]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/1397—Single layer [continuous layer]
Definitions
- Angioplasty also known as percutaneous transluminal angioplasty (PTA) or percutaneous transluminal coronary angioplasty (PTCA) is a procedure for dilating or reopening narrowed or occluded blood vessels (usually arteries, more rarely veins).
- PTA percutaneous transluminal angioplasty
- PTCA percutaneous transluminal coronary angioplasty
- a common method of angioplasty is balloon dilatation.
- interventional radiology, cardiology, and angiology are understood to be a method of dilating pathologically constricted blood vessels by means of a balloon catheter, a vascular catheter with a balloon attached thereto, which slowly inflates at the constricted site under high pressure (FIG -20 bar).
- a balloon catheter a vascular catheter with a balloon attached thereto, which slowly inflates at the constricted site under high pressure (FIG -20 bar).
- the balloon catheters are usually placed from the groin over a guide wire and guide catheter into the stenosis (bottleneck) and inflated with pressure. This eliminates the bottleneck and avoids operation.
- catheters with a deflated balloon are also used for the placement of stents.
- the catheter carries a stent in the region of the deflatable balloon, which can be placed in the vessel after deflation of the balloon after reaching the desired location in the blood vessel.
- Polyamides and Peba materials for catheter construction are mostly based on the polyamide 12 (PA12) basic structure.
- PA12 polyamide 12
- This polyamide is characterized by high strength and toughness, low water absorption and associated property changes as well as by a good availability of the raw materials.
- PA12 is a common catheter material and is often used as a base material for catheter balloons for reasons of good ductility. The practical application requires for balloon components a high compressive strength, a small wall thickness, but also a high softness of the cones.
- the orientation and crystallinity properties of the material are specifically influenced.
- the extensibility and hence orientation of the polymer can be increased by additives that increase the lubricity of the molecular chains together and / or reduce the crystallization of the polymer prior to deformation, such. B. by using suitable plasticizers and / or solvents.
- PA12-based systems typically have a glass transition point of about 50 ° C. Temperatures above 50 ° C are used to blow-mold the balloon components. To shape a shape memory in these components, z. B. for folding and stent fixation a forced form and a conditioning used above or around the glass point. In principle, heating of the blow-molded components in the region and beyond the glass transition temperature allows a relaxation of the stresses impressed by the plastic shaping. The relaxation causes, for example, a hysteresis between the first and further, subsequent pressure loads of the balloon component. As a competitive effect, the crystallization of the polymer progresses from 50 ° C on.
- ETO ethylene oxide sterilization
- the ETO sterilization processes will be performed at 50 ° C under thermal conditions.
- this thermal load in the presence of moisture represents the absolute minimum of relaxation of PA12-based components during the manufacture of the catheter.
- the balloon component is conditioned by thermal methods so that reproducible dimensions are obtained after sterilization which are then no longer significantly changed by simulated aging and storage.
- this also means that the balloon inflation of the first inflation is more or less different from all subsequent inflation, and steeper at the first inflation.
- This effect is also associated with a diameter increase of the balloon component. Since the compliance of these components is determined at the first inflation, subsequent balloon inflation leads to some systematic over dilatation of the vessels. The diameter increase of the balloons with increasing number of inflations and inflation intensity is thus a safety-relevant quality criterion.
- the further development of these dilatation balloons is thus generally characterized by the search for technical solutions, which have the precision of the dilatation, the profile of the catheter product and the maintenance of good performance properties of the balloon component to the goal.
- the object of the present invention is to reduce or avoid one or more disadvantages of the prior art.
- the present invention achieves this object by providing a catheter with a dilatable balloon, characterized in that the primary balloon wall is formed of a material comprising or consisting of a polyamide / polyvinylpyrrolidone (PA / PVP) polymer blend.
- PA / PVP polyamide / polyvinylpyrrolidone
- a polymer mixture or blend is produced, which can be used for the preparation of the primary balloon wall of the dilatable balloon of a catheter as well as for components of the shaft.
- the obtained balloon or the components obtained are characterized by an increase in the deformation limits, as well as by a delay in crystallization, an increase in elasticity, or a generally small decrease in the modulus of elasticity and leads to an increase in the glass point in the dry Condition of the sample.
- This property spectrum is technically of high interest, because the increase in elasticity extends the deformation limits in the blowing process and can achieve a higher reinforcement effect by increasing the orientation of the polymer.
- the reduction of the E-modulus of the material can thus be compensated for with a suitable design by a gain in orientation of the polymer. This leads to a significant improvement in the performance characteristics of the balloon.
- the delayed crystallization after extrusion leads to improved and more tolerant deformation limits, which is particularly advantageous for balloon deformation and its process stability.
- By the softer cones of the balloon for example, an improved refolding ability is made possible after inflation of the balloon component.
- the increase of the deformation limits creates the possibility for the cylindrical area of the balloon to achieve a higher stretching and thus a reduction Ornamentation of the modulus of elasticity and possibly also to counteract increased compliance of the balloon component as a higher orientation of the stretch-formed component can be achieved.
- the crystallization of the blend is primarily delayed in time, so it can still be increased by a suitable process technology to a maximum.
- z. B. the polymer matrix PA12 at molecular weights corresponding to commercial PVP Type K30 from a concentration of about 3% by weight addition under crystallization conditions, the diffusion of the PVP additive is carried out in edge regions of the component, as may also be observed in precipitated phases.
- Balloon components made of a blend of PA12 / PVP can under unfavorable process conditions after crystallization tend to form punctiform failing areas, so-called "pin holes.” The development of such components should thus adhere to a molecular weight-dependent limit concentration.
- the balloons have an elevated glass point when dry and thus tend to have very little relaxation during dry storage and dry thermal treatment. In ETO sterilization cycles no conspicuously increased relaxation was observed despite the increased moisture absorption capacity of fabricated balloon components.
- PVP is enriched at the phase boundary. While polyamides usually have a low reactivity and wettability on the surface, the presence of PVP on the surface shows an adhesion-promoting, wetting effect as well as a hydrophilizing effect. So z. B. observed after the formation of balloon components in a water bath complete wetting of the surface with water and haptically observed a lower lubricity.
- Dilatations in the area of the left atrium, adjacent pulmonary veins, the left ventricle, and the aortic valve area must be performed with relatively large balloons because of their dimensions. These should typically be prepared without bubbles, as they can potentially release gas bubbles in the event of failure and cause microemboli in brain and coronary tissues.
- the invention relates essentially to a catheter with a dilatable balloon.
- catheters which are suitable for applying a stent and have a dilatable balloon for this purpose.
- these also mean catheters whose dilatable balloon can be used directly therapeutically, for example as part of a balloon dilatation for widening vascular constrictions.
- any known catheter system may be used for the catheter according to the invention, preferably any catheter system which comprises a dilatable balloon.
- the invention relates to a catheter having an inner shaft to which at the distal end a dilatable balloon is attached, which in an unexpanded deflated state at least partially abuts an outer surface of the inner shaft.
- catheters of the intended type may also have an outer shaft which extends at least as far as a proximal end of the balloon and is connected to it in a fluid-tight manner.
- an outer shaft which extends at least as far as a proximal end of the balloon and is connected to it in a fluid-tight manner.
- a cavity enclosed by the inner shaft and extending in the longitudinal direction of the inner shaft is provided as a lumen.
- This lumen serves for example to receive a stylet or a guide wire.
- the catheter and guidewire are adapted to allow the guidewire to exit at the distal tip of the catheter and to be controlled from the proximal end.
- the guidewire is deflected, for example, by means of control means so that it is easy to insert into branching blood vessels.
- the balloon catheter can then be pushed along the guidewire.
- the catheters according to the invention have the dilatable balloon already mentioned at their distal end.
- the balloon is compressed and fits tightly against the inner shaft of the catheter.
- By inflating the balloon with a fluid it can be expanded or dictated. This expansion of the balloon happens as soon as the area of the catheter with the dilatable balloon is guided to the intended position.
- a stent can be applied or a surface of the balloon is applied to a vessel wall. This is done, for example, for the purpose of widening vessel stenoses (stenoses) by means of the balloon of the catheter.
- the catheter according to the invention is characterized in that the primary balloon wall of the dilatable balloon is formed from a material which comprises or consists of a PA / PVA polymer mixture.
- the primary balloon wall is meant the wall which encloses the lumen of the balloon and thus forms the balloon.
- the primary balloon wall forms the base of the balloon or its wall on which, if necessary, additional materials and / or coatings can later be applied.
- the primary balloon wall expressly does not include such additional or post-added coatings that can be applied or applied to the interior and / or exterior surface of the primary balloon wall.
- the PA / PVP polymer mixture refers to a polymer blend containing or consisting of the two polymer types polyamide (PA) and polyvinylpyrrolidone (PVP).
- a polymer mixture or polymer blend is understood to mean a physical mixture of the polymers and is present as a macroscopically homogeneous mixture of the various polymers. There is no chemical reaction between the different polymers. It is discussed in the literature that formation of a complex between polyamide bonds of the PA and the pyrrole ring of the PVP may occur.
- Polymer blends or blends are prepared by mechanically blending molten polymers to give a homogeneous material.
- polymer blends can be achieved by adding and melting the one polymer in solid or liquid form into the melt of the other polymer. Upon cooling of the mixed melt, the different polymer chains remain mixed and it is believed that, with sufficiently intense mixing and sufficiently low dosage, a physical mixture of both polymers is achieved, which also remains intact.
- the PA / PVP polymer mixture consists of a polyamide and a polyvinylpyrrolidone and may optionally contain other ingredients such as solvents and / or plasticizers.
- An interesting variant may also be the use as a processing aid for dispersing fillers or reinforcing substances because of the wetting effect.
- an Exfoil ist of phyllosilicates (Clays) in aqueous solution in the presence of PVP possible.
- a spray-drying process can be used to produce a free-flowing powder which can be fed to the compounding by means of a gravimetrically metering vibrating trough. Since the increase in viscosity of the clays in aqueous solution is considerable and can lead to procedural problems, the Exfoiltechnik of the clays in a water-containing mixture, for. B. an alcohol water mixture can be used.
- shale silicate should be less than 7% (weight) and about 1-5% (weight) of PVP.
- the weight proportions of the polyamide and the polyvinylpyrrolidone fractions together preferably form 100% by weight of the PA / PVP polymer mixture.
- the proportion by weight of the PVP in the PA / PVP polymer mixture is always ⁇ 10% by weight, based on the total weight of the PA / PVP polymer mixture.
- the proportion by weight of the polyvinylpyrrolidone fraction in the PA / PVP polymer mixture is preferably from 0.01 to 7% by weight, based on the total weight of the PA / PVP polymer mixture, particularly preferably from 0.5 to 5% by weight), very particularly preferably from 1 to 3% by weight .%>.
- Polyvinylpyrrolidone is preferably used in the PA / PVP polymer mixture with an average molar mass of oligomeric compounds up to compounds with an average molar mass of 2,500,000 g / mol.
- the polyvinylpyrrolidone portion of the PA / PVP polymer mixture may contain or consist of a polyvinylpyrrolidone having a K value of 20 to 100, preferably PVP having a K value (Fikentscher K value) of 30 to 90, particularly preferably PVP with a K. Value of 30, 60 or 90. It may prove advantageous to deliberately reduce the molecular weight of PVP by means of a suitable process technology, wherein preferably high-molecular constituents are to be degraded. This reduction of the molecular weight can be achieved, for example, by the action of intensive mechanical shearing (Ultraturrax dissolver) as well as by intensive ultrasound influence on dissolved PVP.
- intensive mechanical shearing Ultraturrax dissolver
- the proportion by weight of the polyamide in the PA / PVP polymer mixture is always> 10% by weight, based on the total weight of the PA / PVP polymer mixture.
- the polyamide portion of the PA / PVP polymer blend may include only one particular polyamide or a blend of different polyamides.
- the polyamide may be a homopolymer or a copolymer.
- the polyamide portion of the PA / PVP polymer mixture preferably contains or consists of a polyamide which is selected from PA5, PA6, PA7, PA8, PA9, PA10, PA11, PA12, PA13, PA14 and / or PA15 or a copolymer containing at least one monomer aforementioned type, preferably of PA6, PA7, PA8, PA9, PA10, PA11 and / or PA12 or a copolymer containing at least one monomer of the aforementioned type, particularly preferably the polymer is a PA12.
- polyurethanes or peptides can be used in the polymer mixtures according to the invention.
- PVP copolymers in the polymer mixtures according to the invention (for example the product family sold under the trade name Luvitec).
- the PA / PVP polymer mixture of the catheter according to the invention can be prepared and / or compounded by known methods.
- the PA / PVP - polymer mixture is prepared by compounding, since both a gentle, as well as adapted shear for mixing is feasible. A weight-controlled metering of the individual components is state of the art in this process.
- the polymer mixture is preferably prepared in a twin-screw compounder with gravimetric dosing for granules and the PVP in pulverulent consistency. In this case, the dried, finely dispersed PVP z. B. supplied via a vibrating chute of a PA melt.
- the use of a protective gas atmosphere as well as a vacuum Re-degassing of the plasticized and mixed melt prior to strand formation is advantageous.
- further components of the catheter may be made of a material which comprises or consists of a PA / PVP polymer mixture.
- the catheter according to the invention can have an active substance-releasing coating and / or cavity filling at least on parts of the outer surface of the dilatable balloon.
- the coating may also cover the entire outer surface of the balloon.
- a coating according to the invention is an at least partial application of the components of the coating to the outer surface of the dilatable balloon of the catheter.
- the surface of the balloon is referred to as the outer surface, which is usually contactable or brought into contact with the vessel wall during clinical use.
- the entire outer surface of the balloon is covered by the coating.
- a layer thickness is preferably in the range of 1 nm to 100 ⁇ , more preferably in the range of 300 nm to 50 ⁇ .
- the coating can be applied directly to the balloon surface.
- the processing can be carried out according to standard methods for the coating.
- Single-layered but also multi-layered systems (for example so-called base coat, drug coat or drug comprising topcoat layers) can be produced.
- the coating may be applied directly to the balloon body or further layers may be provided therebetween.
- the catheter may have a cavity filling.
- the cavity is usually located on the outer surface of the dilatable balloon. Methods for coating catheters and for attaching cavity fillings to catheters are known to those skilled in the art.
- the present invention also relates to a method for producing the balloon of a catheter according to the invention, wherein the characteristic method step is the choice of the temperature, optionally in combination with the choice of pressure, at which the balloon formation takes place.
- the other method steps are essentially identical to the steps of known methods for producing balloons for catheters from Po. lyamides, in particular from PA12 or Pebax and are not reproduced here in detail.
- the balloon formation takes place from a PA / PVP polymer mixture at a temperature of> 50 ° C., preferably at a temperature of> 80 ° C.
- the balloon forming takes place in a water bath or via a stretch-blow process.
- the invention also relates to the use of a material which comprises or consists of the abovementioned PA / PVP polymer mixture for the production of catheters, in particular of balloon catheters, preferably for producing a dilatable balloon of a catheter.
- the PA / PVP polymer mixture is produced using a twin-screw compounder at gravimetric dosing.
- the polyamide was routinely preconditioned in a convection dryer.
- the PVP was previously dried overnight in a vacuum oven at 120 ° C and a pressure ⁇ 50 mbar dried.
- the conditioning temperatures had to be significantly increased compared to unmodified polyamide.
- polyamides are blown at the applied process technology at about 80 ° C and pressures around 40 bar.
- the balloons of the PA / PVP polymer blends are blown at a temperature of about 95 ° C at a pressure of about 40 bar.
- the molded PA / PVP balloons develop "explosively", while the prior art pure polyamide balloons are less abrupt in shape.
- the freshly demolded balloons from the water bath have a slightly “slippery” behavior compared to pure polyamide balloons.
- the hoses made of the PA / PVP polymer mixture can be shaped to higher radial stretching rates than pure polyamide balloons. Balloons with very flexible and thin received a cone. The PA / PVP balloons often showed pin-holes. This indicates that the compounding can be carried out under more aggressive conditions than previously realized and possibly even the concentration of PVP can be reduced.
- the "pinhole” frequency is amplified by an additional annealing process. The accumulation of "pin-holes" and the slippery behavior of the PA / PVP balloons after demolding from the water bath process suggest that the PA / PVP polymer mixture at high temperatures continues to crystallize and restructure the polymer matrix and PVP from crystallizing areas of the polymer is displaced.
- Blends of nylon 12 (Grilamid L25) and 6 wt% PVP (K30 Bayer) were obtained with blanks of 7.0 mm in mold diameter.
- the PA / PVP balloons have double wall thicknesses around 50 ⁇ and an increase in diameter at 6 to 12 bar of 7.21 mm to 7.56 mm. Bursting pressures of approx. 13-14 bar were reached. This indicates a compressive strength between PA12 and Pebax 7033, and interestingly, the compliance remains well below that of comparably produced Pebax balloons.
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201180058101.9A CN103249435B (en) | 2010-12-21 | 2011-11-23 | As polyamide/polyethylene ketopyrrolidine (PA/PVP) polymeric blends of tube material |
JP2013545144A JP5848776B2 (en) | 2010-12-21 | 2011-11-23 | Polyamide / polyvinylpyrrolidone (PA / PVP) polymer blend as catheter material |
CA2816573A CA2816573C (en) | 2010-12-21 | 2011-11-23 | Polyamide/polyvinylpyrrolidone (pa/pvp) polymer mixtures as catheter matterial |
US13/995,679 US9033918B2 (en) | 2010-12-21 | 2011-11-23 | Polyamide/polyvinylpyrrolidone (PA/PVP) polymer mixture as catheter material |
EP11788432.0A EP2654818B1 (en) | 2010-12-21 | 2011-11-23 | Polyamide/polyvinylpyrrolidone (pa-pvp) blend as cathether material |
ES11788432.0T ES2674427T3 (en) | 2010-12-21 | 2011-11-23 | Polymer mixture of polyamide / polyvinylpyrrolidone (PA / PVP) as catheter material |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061425254P | 2010-12-21 | 2010-12-21 | |
US61/425,254 | 2010-12-21 |
Publications (1)
Publication Number | Publication Date |
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WO2012084390A1 true WO2012084390A1 (en) | 2012-06-28 |
Family
ID=45047765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2011/070814 WO2012084390A1 (en) | 2010-12-21 | 2011-11-23 | Polyamide/polyvinyl pyrrolidone (pa/pvp) polymer mixtures as a catheter material |
Country Status (7)
Country | Link |
---|---|
US (1) | US9033918B2 (en) |
EP (1) | EP2654818B1 (en) |
JP (1) | JP5848776B2 (en) |
CN (1) | CN103249435B (en) |
CA (1) | CA2816573C (en) |
ES (1) | ES2674427T3 (en) |
WO (1) | WO2012084390A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104623740B (en) * | 2013-11-15 | 2018-02-16 | 微创心脉医疗科技(上海)有限公司 | A kind of medicinal balloon and preparation method thereof |
SG11201700976PA (en) * | 2014-08-20 | 2017-03-30 | Biotronik Ag | Method for producing a balloon for angioplasty |
US11653967B2 (en) | 2018-05-03 | 2023-05-23 | Boston Scientific Scimed, Inc. | System and method for balloon diameter hysteresis compensation |
CN111202896A (en) * | 2018-11-05 | 2020-05-29 | 上海微创心通医疗科技有限公司 | Balloon dilatation catheter, balloon and preparation method thereof |
Citations (3)
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EP0697219A2 (en) * | 1994-07-25 | 1996-02-21 | Advanced Cardiovascular Systems, Inc. | Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters |
DE19933279A1 (en) * | 1999-07-14 | 2001-03-01 | Biotronik Mess & Therapieg | Polymer blend useful for medical instruments such as balloon catheters, comprises partially crystalline polyamide polymer and a polystyrene thermoplastic elastomer flexibilizing agent |
WO2006065905A1 (en) * | 2004-12-16 | 2006-06-22 | Medtronic Vascular, Inc. | Polymer blends for medical balloons |
Family Cites Families (6)
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US5001009A (en) * | 1987-09-02 | 1991-03-19 | Sterilization Technical Services, Inc. | Lubricious hydrophilic composite coated on substrates |
US4898591A (en) * | 1988-08-09 | 1990-02-06 | Mallinckrodt, Inc. | Nylon-PEBA copolymer catheter |
EP2106820A1 (en) * | 2008-03-31 | 2009-10-07 | Torsten Heilmann | Expansible biocompatible coats comprising a biologically active substance |
AU2009270849B2 (en) * | 2008-07-17 | 2013-11-21 | Micell Technologies, Inc. | Drug delivery medical device |
CN101455861B (en) * | 2008-12-17 | 2013-01-02 | 东南大学 | Lubricity coatings preparation method on the medical catheter polymers surface |
WO2010096332A2 (en) * | 2009-02-20 | 2010-08-26 | Boston Scientific Scimed, Inc. | Hydrophilic coating that reduces particle development on ester-linked poly(ester-block-amide) |
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2011
- 2011-11-23 ES ES11788432.0T patent/ES2674427T3/en active Active
- 2011-11-23 EP EP11788432.0A patent/EP2654818B1/en active Active
- 2011-11-23 CN CN201180058101.9A patent/CN103249435B/en active Active
- 2011-11-23 CA CA2816573A patent/CA2816573C/en not_active Expired - Fee Related
- 2011-11-23 JP JP2013545144A patent/JP5848776B2/en active Active
- 2011-11-23 WO PCT/EP2011/070814 patent/WO2012084390A1/en active Application Filing
- 2011-11-23 US US13/995,679 patent/US9033918B2/en active Active
Patent Citations (3)
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EP0697219A2 (en) * | 1994-07-25 | 1996-02-21 | Advanced Cardiovascular Systems, Inc. | Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters |
DE19933279A1 (en) * | 1999-07-14 | 2001-03-01 | Biotronik Mess & Therapieg | Polymer blend useful for medical instruments such as balloon catheters, comprises partially crystalline polyamide polymer and a polystyrene thermoplastic elastomer flexibilizing agent |
WO2006065905A1 (en) * | 2004-12-16 | 2006-06-22 | Medtronic Vascular, Inc. | Polymer blends for medical balloons |
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EP2654818A1 (en) | 2013-10-30 |
EP2654818B1 (en) | 2018-03-21 |
CA2816573C (en) | 2016-01-26 |
JP5848776B2 (en) | 2016-01-27 |
US9033918B2 (en) | 2015-05-19 |
US20130324922A1 (en) | 2013-12-05 |
JP2014501587A (en) | 2014-01-23 |
CA2816573A1 (en) | 2012-06-28 |
CN103249435A (en) | 2013-08-14 |
CN103249435B (en) | 2015-11-25 |
ES2674427T3 (en) | 2018-06-29 |
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