CN104623740B - A kind of medicinal balloon and preparation method thereof - Google Patents
A kind of medicinal balloon and preparation method thereof Download PDFInfo
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- CN104623740B CN104623740B CN201310572145.4A CN201310572145A CN104623740B CN 104623740 B CN104623740 B CN 104623740B CN 201310572145 A CN201310572145 A CN 201310572145A CN 104623740 B CN104623740 B CN 104623740B
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- balloon
- biodegradable polymer
- adhesive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/148—Materials at least partially resorbable by the body
Abstract
The invention belongs to medical instruments field, and in particular to a kind of medicinal balloon and preparation method thereof.The medicinal balloon of the present invention includes double-layered balloon, and its superficies is sequentially coated with water-soluble bottom and the biodegradable polymer layer of drug containing.The medicinal balloon of the present invention has the advantages that：The solution such as physiological saline are had during its outer layer balloon expandable to ooze out from balloon wall, dissolve water-soluble bottom, so as to control the release of the biodegradable polymer layer of drug containing；The polymeric layer can uniformly discharge medicine to whole pathological tissues for a long time, and drug concentration enough around sick cell is maintained within considerable time；Biodegradable polymer layer (film) can also include adhesive, it is adhered to blood vessel and have certain toughness, will not be broken because of external force such as the compressing of blood vessel, torsions as support.
Description
Technical field
The invention belongs to medical instruments field, and in particular to a kind of medicinal balloon and preparation method thereof.
Background technology
Hemadostewnosis is morbidity and main causes of death, and therapeutic modality the most frequently used at present is to use bracket for eluting medicament
(DES) PCI.DES is that rack surface is coated on after medicine is mixed with polymer substrate, forms a topical remedy and delays
Slow release place system.After stenter to implant blood vessel, medicine meeting slow release continued for several weeks to time several months, the support plus support is made
With can effectively treat the narrow or inaccessible of blood vessel, be presently the most one of conventional and maximally efficient intervention apparatus.But
DES also has many weak points, for example, polymer can produce local chronic inflammatory reaction；The presence of support needs long-term anti-blood
Platelet drug therapy；Medication coat skewness；After Thrombosis in sten, support etc. should not be implanted into again.
In order to overcome above-mentioned deficiency, especially seeking solve in-stent restenosis, lower Extremity Arterial Diseases, at vascular bifurcation
And thin vessels it is narrow the problems such as when a kind of novel product -- the medicament elution sacculus (DEB) that has been born.DEB technologies are that one kind changes
Sacculus is sent to lesion locations by the balloon reconstruction entered, the technology in sacculus outer surface medication, by conduit, and
(0-2min) discharges medicine in the of short duration time of balloon expandable, plays expansion blood vessel, the narrow or inaccessible effect for the treatment of.It is even if sick
Become angiogenesis ISR to block, also Retreatment can be carried out by DEB.
But current medicinal balloon requires that the medicine for treating disease must have the effect that：Pass through list
Secondary heavy dose of administration reaches the purpose cured the disease, and repeat administration is non-necessary.This greatly limits the selection of medicine, and
And medicine easily causes acute toxic reaction into the circulatory system after disposable heavy dose of administration.
Current biodegradable stent part overcomes traditional DES limiting factor, will not cause inflammatory reaction and again endothelium
Change difficulty, can slowly discharge medicine relative to DEB.But the limited area because it releases the drug, and the support strength of support
It is undesirable, the factor such as be easily broken off, can not produce a desired effect.Thus, it is necessary to medicaments uniformity is released in comprehensive medicinal balloon
In the characteristics of putting and drug stent the characteristics of long-term slowly release, a kind of new contain medicine coating so as to develop.
WO2012/039884A1 discloses a kind of transferable polymer coating, by by water-soluble material and degradable poly
Compound is respectively coated on common balloon surface, and whole coating then is immersed into a period of time in the aqueous solution, dissolves the water-soluble of nexine
Property material, so as to form the structure of a nested biodegradable polymer layer on the outside of sacculus.The shortcomings that invention, is：
(1) nexine water-soluble material is tightly coated with by outer layer degradable polymer, and hydrone is difficult to cross outer barrier, in many cases
Even if soaking for a long time, internal layer water-soluble material can not dissolve；On the other hand, even if the water-soluble material dissolving of nexine, it
The aqueous solution also be difficult to flow out with hydrone completely, although such a solution has certain lubricity under the conditions of having water existing,
But after once coating is dried, and by sacculus and outer layer adhesion；(2) even if by immersion treatment, nexine is completely removed, sacculus
There is no entity connection between wall and biodegradable polymer layer, the processing such as this directly contributes drug coat and the folding pressure in later stage is held
The movement of process middle polymeric layer, or even come off；(3) in addition, polymeric layer is a very thin tunic, do not have as support
Supporting role, also will not actively it is adherent, once after sacculus is withdrawn from, the film resided at blood vessel is easy to by blood flow
Wash away, do not have the purpose for the treatment of disease not only, or even cause serious blood vessel embolism.
Chinese invention patent application No.200610025200.8 discloses a kind of double-layered balloon catheter, internal layer in two layers of sacculus
Sacculus play a part of expand blood vessel, and outer layer sacculus by uniqueness microporous barrier be made, can by rise therapeutic action gene or
Medicine is by outer layer sacculus osmosis on vascular wall, target organ.It is defeated in angiography catheter that the invention effectively overcomes medicine
Loss during sending, system toxicity is reduced, but be not reaching to the purpose of long-acting slow-release.
The content of the invention
In order to solve above problem, the present invention devises a kind of coating of medicinal balloon, and the coating coordinates special bilayer
Sacculus.During operation, internal layer sacculus carries out angioplasty first, then outer layer balloon expandable.In the process, physiological saline etc.
Solution oozes out from the aperture of outer layer balloon wall, dissolves water-soluble bottom, so that the effect of bottom is changed into lubricating from articulamentum
Layer, the biodegradable polymer layer (film) of drug containing departs from from the surface of outer layer sacculus, then sacculus is withdrawn from vitro.Drug containing
Biodegradable polymer layer uniformly discharges medicine within several minutes of times to the several months in whole diseased region.Biodegradable polymer layer
(film) can also include adhesive, it is adhered to blood vessel and have certain toughness, compressing, torsion that will not be because of blood vessel
It is broken as support etc. external force, will not be also come off from diseased region.
Specifically, the present invention provides a kind of medicinal balloon, including double-layered balloon, it is characterised in that the double-layered balloon
Outer layer balloon surface on be provided with coating, the coating includes water-soluble bottom and the biodegradable poly of drug containing successively
Compound layer.
According to the present invention, the medicine is scattered in biodegradable polymer layer, or in biodegradable polymer layer
On separately coating one layer of medicine layer.
According to the present invention, the biodegradable polymer layer of the drug containing further contains adhesive.In this case,
The biodegradable polymer layer is the Rotating fields for including biodegradable polymer, adhesive and medicine, or bag
The double-decker of any combination containing three, or be the three-decker being respectively coated.
According to the present invention, a Rotating fields are after blending biodegradable polymer, adhesive and medicine, to apply together
Cloth is on water-soluble bottom.
According to the present invention, the double-decker can in any combination, as long as combination after, including biodegradable polymer,
Adhesive and medicine are just.For example, the double-decker can be degradable polymer and adhesive one Rotating fields of composition, and medicine
Thing is separately formed another Rotating fields, or degradable polymer is separately formed a Rotating fields, and adhesive and medicine composition are another
Rotating fields, or degradable polymer and adhesive form a Rotating fields, and medicine and adhesive form another Rotating fields, or
Degradable polymer and medicine form a Rotating fields, and adhesive is separately formed a Rotating fields, or degradable polymer, glue
Stick and medicine form a Rotating fields, and adhesive and/or medicine and/or degradable polymer form another Rotating fields etc..
According to the present invention, the three-decker can be arranged with random order, for example, being biodegradable polymer knot successively
Structure layer, adhesive structure sheaf and medicines structure layer.
It will be appreciated by those skilled in the art that either double-decker or three-decker, in order to ensure double-deck or three-layered node
Structure is adhered to blood vessel, and the structure sheaf containing adhesive is in whole or in part outside, in the dissolving of water-soluble bottom, to release
It can be contacted after putting with blood vessel.
The present invention also provides a kind of preparation method of medicinal balloon, including provides double-layered balloon, in its outer layer balloon surface
Water-soluble bottom is made, then makes the biodegradable polymer layer of drug containing and optional adhesive.
Described biodegradable polymer layer can be attached to the blood vessel of lesion region, at several minutes to the several months not
Deng time in release medicine.
Described double-layered balloon and sacculus disclosed in Chinese invention patent application No.200610025200.8 are completely the same.
Described water-soluble bottom is also known as hydrophilic bottom layer, has certain adhesion strength in the state of anhydrous, for even
Connect the biodegradable polymer layer of balloon surface and drug containing and optional adhesive；Once meeting water can dissolve rapidly, lubricating layer is formed,
So as to which smoothly biodegradable polymer layer be discharged.Described water-soluble material includes starch, cellulose, natural plant gum, animal glue
Etc. water-soluble macromolecule；Modified starch and modified cellulose；CMS, acetic starch, hydroxymethyl cellulose, carboxylic first
The chemically modified natural polymerses such as base cellulose；Polyacrylamide (PAM), hydrolyzed polyacrylamide (HPAM), polyvinyl pyrrole
The synthetic polymers such as alkanone (PVP).
The biodegradable polymer layer of the drug containing and optional adhesive is capable of being fast degraded or dissolves, such as in art
Afterwards several days it is even less, in another example postoperative 5 minutes to 24 hours.In yet some other cases, described biodegradable polymer layer
Slowly it can degrade or dissolve, such as from 5 days to 6 months.In this process, biodegradable polymer layer combination medicine pastes
Lesion vesselses inwall is attached to until medicine is completely absorbed or coating is degradable.The thickness of biodegradable polymer layer is according to institute
The degradation time needed can make the appropriate adjustments, generally less than 10 μm, for example, 0.2 μm -9 μm or 0.5 μm -8.5 μm.
Described biodegradable polymer can be polyhydroxyalkanoate (PHA), poly butyric esters compound,
The poly-alpha-hydroxy acid compounds such as poly- (glycerine-decanedioic acid), polypeptide, PLA (PLA), polyglycolic acid (PGA), poly- breast
Acid-co-glycolic acid (PLGA), PPDO, PLA-polyethylene oxide copolymer, hyaluronic acid etc..
Polymeric layer can be adhered at blood vessel tissue by described adhesive, prevent from coming off, including gelatin, starch,
Agar, mannosan, alginic acid, polyacrylic acid, polyacrylate adhesive, dextrin, methylcellulose, methyl ethylene
Ether, the copolymer of maleic anhydride, Arabic gum, tragcanth, karaya, tracasol, cyanoacrylate are gluing
Agent, polyurethane tackifier, organosilicon series adhesive, fibrin adhesive, sea-mussel mucin adhesive etc..
Described medicine be antithrombotic, propagation, anti-inflammatory, anti-inflammatory, anti-proliferate, antitumor, antimitotic, suppress cell,
With cell toxicant, anti-angiogenesis, anti-restenosis, the micro-pipe that suppresses, anti-rotation shifting or antithrombotic material, preferably A Xi
Mei Xin, otoginsenoside, aminopterin, antimycoin, arsenic trioxide, aristolochic acid, aspirin, small alkali, ginkgol, thunder
Pa mycin and its derivative, taxol, Docetaxel, antibiotic (particularly actinomycin D), hormone, antibody medicine for cancer
Thing.
The present invention solves that the drug absorption time present in conventional medicament sacculus is short, and uptake is low, and individual difference is big
Problem.Post operation is intervened, polymeric layer carries drug adhesion and uniformly released out of -6 months 5 minutes the time do not waited in diseased region
Put medicine.
The medicinal balloon of the present invention has the advantages that：(1) its coating coordinates special double-layered balloon, in outer layer ball
Capsule has the solution such as physiological saline during expanding and oozed out from balloon wall, and dissolving water-soluble bottom makes it be changed by linkage function
For lubricating function, so as to control the release of the biodegradable polymer layer of drug containing；(2) polymeric layer can be for a long time to whole lesion group
Uniformly release medicine is knitted, drug concentration enough around sick cell is maintained within considerable time；(3) degradable polymer
Layer (film) can also contain adhesive, will not be because of blood vessel so as to be more conducive to be adhered to blood vessel and have certain toughness
Compressing, reverse etc. external force and be broken as support；(4) without support long-term existence in human body, coating can be when relatively short
Interior degraded or dissolving, do not influence endothelialization again；(5) medicine is reduced relative to traditional medicament elution balloons technique, the present invention
Thing loss amount, increase drug absorption, required drugloading rate is small, small to system toxicity.
Brief description of the drawings
In order to more clearly describe technical scheme, briefly introduced below in conjunction with accompanying drawing.It is clear that this
A little accompanying drawings are only some embodiments that the application records.The present invention includes but is not limited to these accompanying drawings.
Fig. 1 is a kind of medicinal balloon provided in an embodiment of the present invention, the Structure of cross section signal after its internal layer balloon expandable
Figure.As illustrated, internal layer sacculus can play a part of angioplasty, now biodegradable polymer layer is still securely joined with ball
Capsule outer wall.
Fig. 2 is a kind of medicinal balloon provided in an embodiment of the present invention, its ectonexine sacculus expand after Structure of cross section
Schematic diagram.As illustrated, when outer layer balloon expandable, its expand liquid (such as physiological saline) can pass through the aperture of sacculus outer wall so as to
Water-soluble bottom is dissolved, so as to which the biodegradable polymer layer of drug containing and optional adhesive separates with sacculus.
Fig. 3 is a kind of medicinal balloon vertical section structural representation provided in an embodiment of the present invention.
Fig. 4 is a kind of structural representation of the medicinal balloon provided in an embodiment of the present invention during sacculus is withdrawn from.Such as figure
Shown, sacculus is withdrawn from vivo, and the biodegradable polymer layer of drug containing and optional adhesive is adhered to blood vessel, is arrived at several minutes
The dissolving or degradation time that several months is not waited are interior to adjacent tissue's release medicine.
Embodiment
For a further understanding of the present invention, the preferred scheme of the present invention is described below in conjunction with embodiment.These
Description is merely illustrative the feature and advantage of medicinal balloon of the present invention, the protection domain being not intended to limit the present invention.
Embodiment 1
1. prepared by double-layered balloon
One double-layered balloon is prepared according to Chinese invention patent application No.200610025200.8 methods described.
2. prepared by coating
Weighing 2g polyvinylpyrrolidones, (ten thousand) PVP, molecular weight 1, are added in 5ml isopropanols (IPA) solution, fully stirred
Mix until PVP is completely dissolved.Double-layered balloon internal layer is expanded, immersed in above-mentioned solution, is then dried in 40 DEG C of baking ovens, forms water
Dissolubility bottom, it is 30.109mm. that calliper, which measures sacculus middle part external diameter,
Weigh 2g Poly(D,L-lactide-co-glycolides (PLGA) (50/50), 0.01g cyanoacrylates and 300mg Japanese yews
Alcohol is dissolved in 10ml tetrahydrofurans (THF) solution, is sufficiently stirred until all the components are completely dissolved.Then water-soluble bottom will be scribbled
The sacculus of layer is immersed in above-mentioned solution, is dried in 40 DEG C of baking ovens, repeats to immerse 3 times.After drying, sacculus pars intermedia is measured in calliper
Position external diameter is 30.121mm.
By calculating, the thickness of biodegradable polymer layer is 6 μm.
Embodiment 2
1. prepared by double-layered balloon
According to Chinese invention patent application No.200610025200.8 methods describeds, a double-layered balloon is prepared.
2. prepared by coating
2g PVP (molecular weight 10,000) are weighed, are added in 5ml IPA solution, are sufficiently stirred until PVP is completely dissolved.Will
Double-layered balloon internal layer is expanded, and immerses in above-mentioned solution, is then dried in 40 DEG C of baking ovens, forms water-soluble bottom, calliper measures ball
Capsule middle part external diameter is 30.109mm.
2g PLGA (50/50) are weighed, 0.01g cyanoacrylates are dissolved in 10mlTHF solution, are sufficiently stirred until institute
There is composition to be completely dissolved.Continue to immerse the sacculus for scribbling water-soluble bottom in above-mentioned solution, then dried in 40 DEG C of baking ovens, weight
Immerse 2 times, be completely dried again.Finally, one layer of taxol is sprayed using ultrasonic spraying technology in polymer layer surface, to ensure to gather
Effective bonding of compound coating and blood vessel, at the coating both ends, each reserved 1mm length does not spray medicine.Calliper is measured in sacculus
Between position external diameter be 30.126mm.
By calculating, the thickness of the biodegradable polymer layer including medicine layer adds up to 8.5 μm.
Embodiment 3
Take with balloon diameter similar in isolated pig arterial blood pipeline section, immediately immerse addition anti-coagulants pig blood in, keep 37
DEG C constant temperature, medicinal balloon by 6F conduits and are kept for 1 minute in a folded configuration, then sacculus intravasation inner chamber, internal layer ball
Capsule expands the purpose that (12atm) reaches angioplastic first, then outer layer sacculus saline injection, and water-soluble bottom dissolving disappears
(about 1 minute) withdraws from sacculus after mistake, and biodegradable polymer layer forms thin film and is adhered at blood vessel.
It is another take with balloon diameter similar in latex flexible pipe, immerse in 37 DEG C of constant temperature phosphate buffers (PBS, pH=7.4), medicine
Thing sacculus enters latex flexible pipe inner chamber in a folded configuration, and internal layer sacculus expands (12atm) first, then outer layer sacculus injection life
Salt solution is managed, (about 1 minute) withdraws from sacculus after water-soluble bottom dissolving disappears, and biodegradable polymer layer forms thin film and is adhered to
Latex tube cavity, this emulsion tube and degradable films are placed in the turning in basket of medicament dissolution instrument, dissolution medium is 37 DEG C ± 0.5 DEG C
Constant temperature PBS (pH=7.4), rotating speed be 100 revs/min, every sampling in 1 hour processing after, HPLC testing drug dissolution situations.
As a result, biodegradable polymer layer discharged about 40% medicine at first 24 hours.
The explanation of above example is only intended to help the core concept for understanding the present invention.It should be pointed out that for this area
Those of ordinary skill for, under the premise without departing from the principles of the invention, can also to the medication coat of sacculus of the present invention and
Its preparation method carries out some improvement and modification, but these are improved and modification also falls into the claimed model of the claims in the present invention
In enclosing.
Claims (15)
1. a kind of medicinal balloon, including double-layered balloon, it is characterised in that be provided with the outer layer balloon surface of the double-layered balloon
Coating, the coating include water-soluble bottom and the biodegradable polymer layer of drug containing successively；The outer layer balloon wall
There is aperture, expansion liquid, when outer layer balloon expandable, the aperture for expanding liquid energy and enough passing through sacculus outer wall are included in outer layer sacculus
And the water-soluble bottom is dissolved.
2. medicinal balloon as claimed in claim 1, it is characterised in that the medicine is scattered in biodegradable polymer layer
In, or separately one layer of medicine layer of coating on biodegradable polymer layer.
3. medicinal balloon as claimed in claim 1, it is characterised in that the biodegradable polymer layer of the drug containing enters one
Step contains adhesive.
4. medicinal balloon as claimed in claim 3, it is characterised in that the biodegradable polymer layer is can comprising biology
One Rotating fields of degradation polymer, adhesive and medicine, or the double-decker of three's any combination is included, or be point
The three-decker not being coated with.
5. the medicinal balloon as described in claim any one of 1-4, it is characterised in that the water-soluble bottom is by water-soluble material
It is made, the water-soluble material is selected from water-soluble macromolecule, modified starch and modified cellulose, chemical modification natural polymerization
Thing or synthetic polymer.
6. medicinal balloon as claimed in claim 5, it is characterised in that the water-soluble material be selected from starch, cellulose,
Natural plant gum or animal glue, the chemically modified natural polymerses are selected from CMS, acetic starch, hydroxymethyl cellulose or carboxylic
Methylcellulose, and the synthetic polymer are selected from polyacrylamide, hydrolyzed polyacrylamide or polyvinylpyrrolidone.
7. the medicinal balloon as described in claim any one of 1-4, it is characterised in that the thickness of the biodegradable polymer layer
Degree is less than 10 μm.
8. medicinal balloon as claimed in claim 7, it is characterised in that the thickness of the biodegradable polymer layer is 0.2 μ
m-9μm。
9. the medicinal balloon as described in claims 8, it is characterised in that the thickness of the biodegradable polymer layer is
0.5μm-8.5μm。
10. the medicinal balloon as described in claim any one of 1-4, it is characterised in that the biodegradable polymer is selected from
Polyhydroxyalkanoate, poly butyric esters compound, poly- (glycerine-decanedioic acid), polypeptide, PLA, polyglycolic acid,
Poly(D,L-lactide-co-glycolide, PPDO, PLA-polyethylene oxide copolymer or hyaluronic acid.
11. the medicinal balloon as described in claim 3 or 4, it is characterised in that the adhesive be selected from gelatin, starch, agar,
Mannosan, alginic acid, polyacrylic acid, polyacrylate adhesive, dextrin, methylcellulose, methyl vinyl ether, suitable fourth
Copolymer, Arabic gum, tragcanth, karaya, the tracasol of enedioic acid acid anhydride, cyanoacrylate adhesive, poly- ammonia
Ester adhesive, organosilicon series adhesive, fibrin adhesive or sea-mussel mucin adhesive.
12. the medicinal balloon as described in claim any one of 1-4, it is characterised in that the medicine be selected from antithrombotic, anti-inflammatory,
Anti-inflammatory, anti-proliferate, antitumor, antimitotic, suppress cell, have cell toxicant, anti-angiogenesis, anti-restenosis, suppress it is micro-
Pipe, anti-rotation is moved or antithrombotic material.
13. medicinal balloon as claimed in claim 12, it is characterised in that the medicine is selected from acemetacin, otoginsenoside, ammonia
Base pterin, antimycoin, arsenic trioxide, aristolochic acid, aspirin, little alkali, ginkgol, rapamycin and its derivative
Thing, taxol, Docetaxel, antibiotic, hormone or antibody curing cancer drug.
14. medicinal balloon as claimed in claim 13, it is characterised in that the antibiotic is actinomycin D.
15. a kind of method for preparing the medicinal balloon as described in any one of preceding claims, including double-layered balloon is provided, at it
Outer layer balloon surface makes water-soluble bottom, then makes the biodegradable polymer layer of drug containing and optional adhesive.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310572145.4A CN104623740B (en) | 2013-11-15 | 2013-11-15 | A kind of medicinal balloon and preparation method thereof |
| PCT/CN2014/091292 WO2015070814A1 (en) | 2013-11-15 | 2014-11-17 | Drug-eluting balloon and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310572145.4A CN104623740B (en) | 2013-11-15 | 2013-11-15 | A kind of medicinal balloon and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN104623740A CN104623740A (en) | 2015-05-20 |
| CN104623740B true CN104623740B (en) | 2018-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310572145.4A Active CN104623740B (en) | 2013-11-15 | 2013-11-15 | A kind of medicinal balloon and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104623740B (en) |
| WO (1) | WO2015070814A1 (en) |
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| CN112402702A (en) * | 2020-12-04 | 2021-02-26 | 上海康德莱医疗器械股份有限公司 | Drug coating composition and drug coating balloon |
| CN117222446A (en) * | 2021-04-12 | 2023-12-12 | 业聚医疗器械(深圳)有限公司 | expandable balloon catheter |
| CN114073813A (en) * | 2021-11-12 | 2022-02-22 | 威高奋威健康科技发展(上海)有限公司 | Improved medicine coating medical balloon catheter |
| CN115990295B (en) * | 2023-02-14 | 2024-04-30 | 上海朗迈医疗器械科技有限公司 | Adhesive polylactic acid implant, preparation method and apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101045175B (en) * | 2006-03-29 | 2012-07-04 | 微创医疗器械(上海)有限公司 | Double-layered balloon catheter |
| AU2009270849B2 (en) * | 2008-07-17 | 2013-11-21 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2012039884A1 (en) * | 2010-09-23 | 2012-03-29 | Boston Scientific Scimed, Inc. | Drug coated balloon with transferable coating |
| WO2012084390A1 (en) * | 2010-12-21 | 2012-06-28 | Biotronik Ag | Polyamide/polyvinyl pyrrolidone (pa/pvp) polymer mixtures as a catheter material |
| WO2012166819A1 (en) * | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
| CN203017550U (en) * | 2012-11-08 | 2013-06-26 | 上海微创医疗器械（集团）有限公司 | Medical balloon |
| CN204050424U (en) * | 2013-11-15 | 2014-12-31 | 微创心脉医疗科技（上海）有限公司 | A kind of medicinal balloon |
-
2013
- 2013-11-15 CN CN201310572145.4A patent/CN104623740B/en active Active
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2014
- 2014-11-17 WO PCT/CN2014/091292 patent/WO2015070814A1/en active Application Filing
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| Publication number | Publication date |
|---|---|
| CN104623740A (en) | 2015-05-20 |
| WO2015070814A1 (en) | 2015-05-21 |
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