WO2012079524A1 - 药粉吸嘴及应用 - Google Patents

药粉吸嘴及应用 Download PDF

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Publication number
WO2012079524A1
WO2012079524A1 PCT/CN2011/084070 CN2011084070W WO2012079524A1 WO 2012079524 A1 WO2012079524 A1 WO 2012079524A1 CN 2011084070 W CN2011084070 W CN 2011084070W WO 2012079524 A1 WO2012079524 A1 WO 2012079524A1
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Prior art keywords
powder
cup
filter
inhaler
dry powder
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PCT/CN2011/084070
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English (en)
French (fr)
Inventor
陈庆堂
陈欣
Original Assignee
Chen Qingtang
Chen Xin
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Application filed by Chen Qingtang, Chen Xin filed Critical Chen Qingtang
Priority to US13/994,759 priority Critical patent/US9610413B2/en
Priority to JP2013543515A priority patent/JP5775168B2/ja
Priority to EP11849145.5A priority patent/EP2653181B1/en
Priority to EA201390781A priority patent/EA028926B1/ru
Publication of WO2012079524A1 publication Critical patent/WO2012079524A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters

Definitions

  • the present invention relates to a medical device, and more particularly to a powder nozzle and application, and more particularly to an appliance that is used alone or in combination with a plurality of dry powder inhalers.
  • a powder nozzle comprising a straw (1) and a filtering member (2), characterized in that it comprises at least one straw (1) penetrating through the front and the back, and one end of the straw (1) is The medicine inlet, the other end (16a) is a suction port, and the suction pipe (1) is provided with a filtering member (2).
  • the straw (1) and the subsequent at least one pipette are sequentially connected by matching, and the filtering member (2) in the suction passage formed by them is a filter cup, or includes a sieve, a net, a cloth, and a membrane.
  • the filtering member (2) in the suction passage formed by them is a filter cup, or includes a sieve, a net, a cloth, and a membrane.
  • the filter member (2) is composed of at least two hollow cups, and the slightly larger hollow cup (a) is covered by a slightly smaller hollow cup (b) of the same shape, and a cup mouth bump (91) and another cup mouth
  • the pits (92) are matched to lock the orientation between the two cups of overlap, so that a plurality of hollows (93) of the cup are separated from the hollow (94) of the other cup, but overlap by two layers of cups.
  • the outermost filter cup wall is not permeable, and a plurality of grooves are provided on the inner side of the peripheral wall to straighten the bottom of the cup (96).
  • the filter bag (2) is placed in the filter cup (a), and the bracket is placed in the mouth of the bag, hooked or fixed at the mouth of the bag, or the cup can be buckled between the cup and the cup of the filter cup (a). open.
  • the number, shape, size, level, and the like of the filter holes of the filter member (2) are set as needed, for example, a powder having a size of 5 ⁇ m or less can be filtered, and an excipient having a size of 6 ⁇ m or more is stopped.
  • the powder nozzles are respectively docked with a plurality of types of dry powder inhalers, or at least two of the powder nozzles are juxtaposed to a plurality of types of dry powder inhalers.
  • the powder nozzle is docked with various types of dry powder inhalers, respectively, including: dry powder inhaler, powder nozzle nozzle box, quasi-nano, Du Bao, China Patent No. ZL200510038681. 1 inhaler.
  • a connecting seat (3) is provided, which is composed of a central pipe body (31) and a joint (5), and the center pipe body (31) is inserted into the suction pipe.
  • the central pipe body (31) is raised (32, 33), hooked to the inner wall of the dry powder suction port, the connection portion (5) is connected with the suction pipe (1), or the connection portion (5) is at least Two straws (1) are connected in parallel.
  • the butt inner tube (8) is a hollow tube, the front end of which is thin and has a flared cavity at the end, and the horn-like cavity may have a sphere (8a), and the horn-shaped cavity port is provided with a fence for blocking the sphere (8b)
  • the front end of the butt inner tube (8) can be directly inserted into the dry powder suction port of the inhaler or inserted into the central tube body (31) of the connecting seat (3).
  • the connecting seat (3) is first inserted into the dry powder suction port of the inhaler, and the protrusion (8d) on the butting inner tube (8) is aimed at the notch (5a) on the connecting seat (3), which will be docked.
  • the inner tube (8) is inserted into the central tube body (31) to lock the orientation, so that the arc shape of the front end of the butt inner tube (8) coincides with the arc shape in the dry suction port of the docked inhaler, and the air leakage is reduced. It is beneficial to suck out the powder in the first time.
  • the invention has the advantages that the powder powder nozzles are respectively docked with a plurality of dry powder inhalers, and the length is short and the curative effect is remarkable.
  • Figure 1 is a schematic cross-sectional view of a straw (1) and a filter member (2) of the present invention
  • FIG. 2 is a schematic view showing the appearance of the connector (3) of the present invention
  • FIG 3 is a schematic cross-sectional view of the butt inner tube (8), the sphere (8a), the fence (8b) and the like according to the present invention.
  • Figure 4 is a filter member (2) of the present invention: (a) schematic view of the outer hollow cup (b) schematic view of the inner layer hollow cup
  • Figure 5 is a suction nozzle and outer casing (111) composed of the straw (1) and the straw (11) of the present invention.
  • Figure 6 is a schematic view showing the docking of the protrusion (45) on the bottom side of the cartridge of the nozzle of the present invention and the powder nozzle.
  • Figure 7 is a schematic view showing the connection of the straw (1), the straw (11), the outer sleeve (111) and the connecting seat (3) of the present invention.
  • Figure 8 is a schematic view of the nozzle and outer sleeve (111), the connecting seat (3) and the susceptor (103) of the present invention.
  • Powder nozzle (see Figure 1). Put the suction port of the straw (1) upwards, put it into the filter (2), pour the powder into the medicine inlet, and then tilt the suction port (16a) of the straw (1) into the inlet cavity to suck the medicine. If the straw (1) feeding port is bent upwards during manufacture, it is convenient to pour the powder into the mouth and not easily pour it out. If the end of the suction port (16a) is extended to about 8 cm, the suction rate is increased. If the suction outlet (16a) is made into a double outlet, it can be used for nasal use. After use, remove the inhaler, blow dry and set aside.
  • the powder nozzle is connected to the powder inhaler (see Figure 5).
  • the filter cup (2) is placed in the lumen of the straw (1), and the straw (11) and the straw (1) are connected to form a nozzle.
  • the ball (8a) into the butt inner tube (8) and fix it to the bell mouth with the fence (8b) ;
  • the butt inner tube (8) is placed in the suction outlet (19a) of the filtered powder inhaler, the nozzle is connected with the filtered powder inhaler connection (10), and then the outer sleeve (111) is covered.
  • the mouth is connected to the joint (10) to form a new powder inhaler.
  • the inhaler put the inhalation capsule into the capsule chamber, and then prick the needle to pierce the capsule.
  • the ball (8a) vibrates, the impacting agent is separated from the powder, and the filter cup (2) is passed through, and the excipient is blocked in the filter cup (2), and the powder is filtered out. Being quickly inhaled into the respiratory tract. If you inadvertently exhale into the mouthpiece, the ball (8a) is blocked in the narrow part of the tube to prevent the powder from being exhaled outside the appliance.
  • the injection molding can also be made of metal, new materials or the like. Make each component separately and match the connections.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Description

药粉吸嘴及应用 技术领域
本发明涉及一种医疗器械，尤其是一种药粉吸嘴及应用，具体地说是单独使用，或分别与多种干粉吸入器配套的器具。
背景技术
现有多种干粉吸入器吸入治疗哮喘，符合GINA治愈率仅约5％。因吸入用药粉微粒易聚集、难分离；药量少，难分装，故掺入乳糖量占干粉总量最多达98.8％，但长期吸入乳糖有副作用；然而为少吸乳糖采取少吸干粉，结果也 減少了药粉量，因此疗效差。
技术问题
本发明的目的在于：提供过滤出药粉的吸嘴，显著提高疗效。
技术解决方案
本发明的目的是这样实现的：一种药粉吸嘴，包括吸管（1）和过滤用件（2），其特征在于：至少包括一节前后贯通的吸管（1），吸管（1）一端为进药口，另一端（16a）为吸出口，吸管（1）中设有过滤用件（2）。
在本发明中：吸管（1）与后续至少一节吸管依次通过匹配的方式连接，它们组成的吸出通道中的过滤用件（2）为过滤杯，或包括用筛绢、网、布、膜、袋，或在整个吸出通道中的任一部位安放过滤用件（2），或在不同部位安放一个以上相同规格的过滤用件（2），或分别安放一个以上不同规格的过滤用件（2）。
在本发明中： 过滤用件（2）至少由两层镂空杯组成，稍大的镂空杯（a）罩在相同形状稍小镂空杯（b）之外，一个杯口的凸点（91）与另一个杯口凹点（92）相匹配，锁定两个杯重叠之间方位，使这层杯的若干镂空处（93）与另一层杯的镂空处（94）岔开，而是通过两层杯重叠之间空隙相通，若设定两层杯重叠之间空隙的距离是10微米，那末10微米以下大小的微粒从空隙处滤出；为避免使用时手拿过滤杯的污染，最外层过滤杯周壁外侧不透空，在其周壁内侧设有数条沟直通杯底部镂空处（96）。
在本发明中：过滤杯（a）内安放过滤袋（2），其袋口内放置支架，勾住或固定在袋口，或支架与过滤杯（a）的杯口之间可扣住或可拆开。
在本发明中：过滤用件（2）的过滤孔数量、形状、大小、层次等根据需要设定，例如5微米以下大小的药粉可滤出，而6微米以上大小的赋形剂被拦住。
在本发明中，所述药粉吸嘴的应用，药粉吸嘴分别与多种型号干粉吸入器对接，或至少由二个所述的药粉吸嘴并列分别与多种型号干粉吸入器对接。
在本发明中，所述药粉吸嘴的应用，药粉吸嘴分别与多种型号干粉吸入器对接，包括：干粉吸入器、药粉吸嘴放置盒、准纳器、都保、中国专利号ZL200510038681.1吸入器。
在本发明中：吸管（1）与吸入器干粉吸出口之间，设有连接座（3），由中心管体（31）与连接处（5）等组成，中心管体（31）***吸入器的干粉吸出口内，中心管体（31）上凸起（32、33），勾住干粉吸出口内壁，连接处（5）与吸管（1）连接，或连接处（5）与至少由二个吸管（1）并列连接。
在本发明中：对接内管（8）为中空管，其前端细、末端呈喇叭状腔，喇叭状腔中可有球体（8a），喇叭状腔端口设有阻挡球体的栅栏（8b），对接内管（8）的前端可直接***吸入器干粉吸出口内，或***连接座（3）的中心管体（31）内。
在本发明中：先将连接座（3）***吸入器干粉吸出口内，再把对接内管（8）上的凸起（8d）瞄准连接座（3）上的缺口（5a），将对接内管（8）***中心管体（31）内，锁定方位，使对接内管（8）的前端弧形等恰好与被对接的吸入器干粉吸出口内的弧形等相符合，减少漏气，有利第一时间吸出药粉。
 有益效果
本发明的优点在于：药粉吸嘴分别与多种干粉吸入器对接，取长补短，疗效显著。
附图说明
图1是本发明吸管（1）与过滤用件（2）剖面示意图
图2是本发明连接座（3）外观示意图
图3是本发明对接内管（8）、球体（8a）、栅栏（8b）等剖面示意图
图4是本发明过滤用件（2）：（a）外层镂空杯示意图 （ b ）内层镂空杯示意图
图5是本发明的吸管（1）、吸管（11）组成的吸嘴和外套管（111） 並与干粉吸入器对接的剖面示意图
图6是本发明吸嘴与药粉吸嘴放置盒的盒底一侧突出部（45）对接示意图
图7是本发明吸管（1）、吸管（11）、外套管（111）与连接座（3）连接示意图
图8是本发明吸嘴及外套管（111）、连接座（3）与准纳器（103）对接示意图
 本发明的实施方式
下面结合附图和实施例对本发明作进一步的说明。
实施例1：
药粉吸嘴（见图1）。将吸管（1）的进药口朝上，放进过滤用件（2），再将药粉倒入进药口内，然后把吸管（1）的吸出口（l6a）倾斜伸入口腔中吸药。如果在制造时就将吸管（1）进药口弯曲成朝上，方便药粉倒入而不易倒出来。如果将吸出口（16a）一端延长至8厘米左右，就提高吸入率。如果将吸出口（16a）制成双出口，可供鼻用。使用后，拆洗吸入器，吹干后备用。
实施例2：
药粉吸嘴与药粉吸入器相对接（见图5）。先将过滤杯（2）放入吸管（1）的管腔内，把吸管（11）与吸管（1）连接成吸嘴。把球体（8a）放入对接内管（8）中，并用栅栏（8b）固定在喇叭口 ； 再将对接内管（8）放进滤出药粉吸入器的吸出口（19a）内，把吸嘴与滤出药粉吸入器连接处（10）相连接，接着将外套管（111）罩住吸嘴，並与连接处（10）相连接成新的药粉吸入器。然后打开吸入器上座，把吸入用胶囊放进胶囊室内，再揿刺针刺破胶囊。当在吸出口（16a）吸药时，球体（8a）震动，撞击赋形剂与药粉分离，又经过滤杯（2），赋形剂被阻挡在过滤杯（2）中，滤出的药粉被快速吸入呼吸道。如果无意中往吸嘴内呼气，球体（8a）堵在管体狭部，避免药粉呼出器具外。
实施例3：
先把舒利迭（103）旋转到吸用状态，露出药粉吸出口，将连接座（3）上的中心管体（31）***药粉吸出口内，再把对接内管（8）上的凸起（8d）与连接座（3）上的缺口（5a）瞄准后插到中心管体（31）内，再取吸嘴与连接座（3）上的连接处5相连接，最后套上吸嘴外套管（111），供吸用（见图7、图8）。
本发明具体实施时，注塑制作，也可用金属、新材料等制成。分别制成各组件，匹配连接。

Claims (10)

  1. 一种药粉吸嘴，包括吸管（1）和过滤用件（2），其特征在于：至少包括一节前后贯通的吸管（1），吸管（1）一端为进药口，另一端（16a）为吸出口，吸管（1）中设有过滤用件（2）。
  2. 根据权利要求1所述的药粉吸嘴，其特征在于：吸管（1）与后续至少一节吸管依次通过匹配的方式连接，它们组成的吸出通道中的过滤用件（2）为过滤杯，或包括用筛绢、网、布、膜、袋，或在整个吸出通道中的任一部位安放过滤用件（2），或在不同部位安放一个以上相同规格的过滤用件（2），或分别安放一个以上不同规格的过滤用件（2）。
  3. 根据权利要求1或2所述的药粉吸嘴，其特征在于：过滤用件（2）至少由两层镂空杯组成，稍大的镂空杯（a）罩在相同形状稍小镂空杯（b）之外，一个杯口的凸点（91）与另一个杯口凹点（92）相匹配，锁定两个杯重叠之间方位，使这层杯的若干镂空处（93）与另一层杯的镂空处（94）岔开，而是通过两层杯重叠之间空隙相通，若设定两层杯重叠之间空隙的距离是10微米，那末10微米以下大小的微粒从空隙处滤出；为避免使用时手拿过滤杯的污染，最外层过滤杯周壁外侧不透空，在其周壁内侧设有数条沟直通杯底部镂空处（96）。
  4. 根据权利要求1、2或3所述的药粉吸嘴，其特征在于：过滤杯（a）内安放过滤袋（2），其袋口内放置支架，勾住或固定在袋口，或支架与过滤杯（a）的杯口之间可扣住或可拆开。
  5. 根据权利要求1～4之一所述的药粉吸嘴，其特征在于：过滤用件（2）的过滤孔数量、形状、大小、层次等根据需要设定，例如5微米以下大小的药粉可滤出，而6微米以上大小的赋形剂被拦住。
  6. 根据权利要求1～5之一所述药粉吸嘴的应用，其特征在于：药粉吸嘴分别与多种型号干粉吸入器对接，或至少由二个所述的药粉吸嘴并列分别与多种型号干粉吸入器对接。
  7. 根据权利要求6所述药粉吸嘴的应用，其特征在于：药粉吸嘴分别与多种型号干粉吸入器对接，包括：干粉吸入器、药粉吸嘴放置盒、准纳器、都保、中国专利号ZL200510038681.1吸入器。
  8. 根据权利要求6或7所述的药粉吸嘴的应用，其特征在于：吸管（1）与吸入器干粉吸出口之间，设有连接座（3），由中心管体（31）与连接处（5）等组成，中心管体（31）***吸入器的干粉吸出口内，中心管体（31）上凸起（32、33），勾住干粉吸出口内壁，连接处（5）与吸管（1）连接，或连接处（5）与至少由二个吸管（1）并列连接。
  9. 根据权利要求6、7或8所述的药粉吸嘴的应用，其特征在于：对接内管（8）为中空管，其前端细、末端呈喇叭状腔，喇叭状腔中可有球体（8a），喇叭状腔端口设有阻挡球体的栅栏（8b），对接内管（8）的前端可直接***吸入器干粉吸出口内，或***连接座（3）的中心管体（31）内。
  10. 根据权利要求8或9所述的药粉吸嘴的应用，其特征在于：先将连接座（3）***吸入器干粉吸出口内，再把对接内管（8）上的凸起（8d）瞄准连接座（3）上的缺口（5a），将对接内管（8）***中心管体（31）内，锁定方位，使对接内管（8）的前端弧形等恰好与被对接的吸入器干粉吸出口内的弧形等相符合，减少漏气，有利第一时间吸出药粉。
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JP2013543515A JP5775168B2 (ja) 2010-12-17 2011-12-15 粉末薬物用のマウスピースおよび応用例
EP11849145.5A EP2653181B1 (en) 2010-12-17 2011-12-15 Powder medicament mouthpiece and application
EA201390781A EA028926B1 (ru) 2010-12-17 2011-12-15 Медицинский мундштук для порошкового медикамента

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