WO2011132051A3 - Tricycle compounds as phosphodiesterase-10 inhibitors - Google Patents

Tricycle compounds as phosphodiesterase-10 inhibitors Download PDF

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Publication number
WO2011132051A3
WO2011132051A3 PCT/IB2011/000846 IB2011000846W WO2011132051A3 WO 2011132051 A3 WO2011132051 A3 WO 2011132051A3 IB 2011000846 W IB2011000846 W IB 2011000846W WO 2011132051 A3 WO2011132051 A3 WO 2011132051A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphodiesterase
inhibitors
tricycle
compounds
tricycle compounds
Prior art date
Application number
PCT/IB2011/000846
Other languages
French (fr)
Other versions
WO2011132051A2 (en
Inventor
Laxmikant Atmaram Gharat
Jitendra Maganbhai Gajera
Neelima Khairatkar-Joshi
Malini Bajpai
Original Assignee
Glenmark Pharmaceuticals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals S.A. filed Critical Glenmark Pharmaceuticals S.A.
Publication of WO2011132051A2 publication Critical patent/WO2011132051A2/en
Publication of WO2011132051A3 publication Critical patent/WO2011132051A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

The present invention provides Phosphodiesterase- 10 inhibitors. In particular, tricyclic derivatives described herein are useful as Phosphodiesterase- 10 inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by Phosphodiesterase- 10. (Formula I) (I)
PCT/IB2011/000846 2010-04-19 2011-04-18 Tricycle compounds as phosphodiesterase-10 inhibitors WO2011132051A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN1273MU2010 2010-04-19
IN1273/MUM/2010 2010-04-19
US32929910P 2010-04-29 2010-04-29
US61/329,299 2010-04-29
IN3314/MUM/2010 2010-12-06
IN3314MU2010 2010-12-06

Publications (2)

Publication Number Publication Date
WO2011132051A2 WO2011132051A2 (en) 2011-10-27
WO2011132051A3 true WO2011132051A3 (en) 2012-01-19

Family

ID=44834563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/000846 WO2011132051A2 (en) 2010-04-19 2011-04-18 Tricycle compounds as phosphodiesterase-10 inhibitors

Country Status (1)

Country Link
WO (1) WO2011132051A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012112946A1 (en) 2011-02-18 2012-08-23 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
CN103755715B (en) * 2013-12-26 2015-12-09 武汉理工大学 Cumarone is [2,3-c] pyridine compounds and synthetic method thereof also
GB201702221D0 (en) 2017-02-10 2017-03-29 Univ Of Sussex Compounds
GB201803340D0 (en) * 2018-03-01 2018-04-18 Univ Of Sussex Compounds
CN108892616A (en) * 2018-08-31 2018-11-27 凯莱英生命科学技术(天津)有限公司 Prepare continuous device and its application of benzaldehydes intermediate
CN110003227B (en) * 2019-04-26 2022-03-11 新乡市润宇新材料科技有限公司 Synthetic method of 2-methyl-8-methoxybenzofuran [2,3-b ] pyridine
CN111499540B (en) * 2020-04-22 2022-09-27 中南民族大学 Method for preparing 2,4,6-trichlorobenzonitrile by ammoxidation method, special catalyst and preparation method
CN115677637B (en) * 2022-09-27 2024-02-23 安徽秀朗新材料科技有限公司 Simple preparation method of 1-bromodibenzofuran
CN117143108B (en) * 2023-08-31 2024-03-19 蒲城欧得新材料有限公司 8-bromo-2-methylbenzofuran [2,3-b ] pyridine and synthetic method

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037805A1 (en) * 2002-10-23 2004-05-06 Glenmark Pharmaceuticals Ltd. Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2004089940A1 (en) * 2003-04-11 2004-10-21 Glenmark Pharmaceuticals S.A. Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2006011024A2 (en) * 2004-07-19 2006-02-02 Glenmark Pharmaceuticals Ltd. New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2006064355A2 (en) * 2004-12-17 2006-06-22 Glenmark Pharmaceuticals S.A. Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
WO2008032171A1 (en) * 2006-09-11 2008-03-20 Matrix Laboratories Ltd. Dibenzofuran derivatives as inhibitors of pde-4 and pde-10
WO2009081222A1 (en) * 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037805A1 (en) * 2002-10-23 2004-05-06 Glenmark Pharmaceuticals Ltd. Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2004089940A1 (en) * 2003-04-11 2004-10-21 Glenmark Pharmaceuticals S.A. Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2006011024A2 (en) * 2004-07-19 2006-02-02 Glenmark Pharmaceuticals Ltd. New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
WO2006064355A2 (en) * 2004-12-17 2006-06-22 Glenmark Pharmaceuticals S.A. Novel heterocyclic compounds useful for the treatment of inflammatory and allergic disorders
WO2008032171A1 (en) * 2006-09-11 2008-03-20 Matrix Laboratories Ltd. Dibenzofuran derivatives as inhibitors of pde-4 and pde-10
WO2009081222A1 (en) * 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands

Also Published As

Publication number Publication date
WO2011132051A2 (en) 2011-10-27

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