WO2011108009A3 - Process for the preparation of fampridine - Google Patents
Process for the preparation of fampridine Download PDFInfo
- Publication number
- WO2011108009A3 WO2011108009A3 PCT/IN2011/000134 IN2011000134W WO2011108009A3 WO 2011108009 A3 WO2011108009 A3 WO 2011108009A3 IN 2011000134 W IN2011000134 W IN 2011000134W WO 2011108009 A3 WO2011108009 A3 WO 2011108009A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fampridine
- preparation
- reducing
- agent
- nitrifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
The present invention relates to a process for the preparation of substantially pure fampridine compound of structural formula (I), (II), (III) comprising nitrifying pyridine-N-oxide hydrochloride with suitable nitrating agent; reducing with suitable reducing agent and purifying by recrystallizing in water followed by treating with an alkyl acetate solvent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN585/MUM/2010 | 2010-03-05 | ||
IN585MU2010 | 2010-03-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011108009A2 WO2011108009A2 (en) | 2011-09-09 |
WO2011108009A3 true WO2011108009A3 (en) | 2012-03-29 |
Family
ID=44259681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2011/000134 WO2011108009A2 (en) | 2010-03-05 | 2011-03-03 | Process for the preparation of fampridine |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011108009A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022124946A1 (en) * | 2020-12-10 | 2022-06-16 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | New polymorphic forms of 4-aminopyridine and pharmaceutical application of same |
CN114751855B (en) * | 2022-05-23 | 2024-05-07 | 上海皓鸿生物医药科技有限公司 | Preparation method of 2-bromo-4-amino-5-methylpyridine |
CN115184486B (en) * | 2022-06-27 | 2023-07-18 | 河北一品生物医药有限公司 | Method for detecting diaminopyridine phosphate related substances by high performance liquid chromatography |
CN116162055B (en) * | 2023-03-10 | 2023-09-12 | 山东汇智药物研究有限公司 | Method for preparing piperidine derivative from pyridine N-oxide derivative |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1879324A (en) | 1929-07-23 | 1932-09-27 | Winthrop Chem Co Inc | Pyridine derivatives and the process of producing them |
US3812137A (en) | 1971-11-29 | 1974-05-21 | American Cyanamid Co | Catalytic production of aniline and other amines from carboxylic acids and ammonia |
US4140853A (en) | 1975-04-18 | 1979-02-20 | Schering Aktiengesellschaft | Process for the preparation of aminopyridines |
CN1311185A (en) | 2000-03-03 | 2001-09-05 | 山东新华制药股份有限公司 | Method for preparing 4-amino pyridine and its derivatives |
JP4475368B2 (en) | 2000-03-10 | 2010-06-09 | 富士電機システムズ株式会社 | Speed sensorless vector controller |
CN1319947C (en) | 2005-01-21 | 2007-06-06 | 北京化工大学 | 4-aminopyridine preparation method |
-
2011
- 2011-03-03 WO PCT/IN2011/000134 patent/WO2011108009A2/en active Application Filing
Non-Patent Citations (3)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WANG, ZHIXIANG ET AL: "Improved preparation of 4-aminopyridine", XP002652907, retrieved from STN Database accession no. 2001:292472 * |
MOSHER H.S. ET AL: "Pyridine-N-oxide", ORGANIC SYNTHESES, vol. 4, no. 33, 1 January 1953 (1953-01-01) - 1 January 1953 (1953-01-01), pages 828 - 830, XP009150355 * |
ZHONGGUO YIYAO GONGYE ZAZHI , 32(2), 83-84 CODEN: ZYGZEA; ISSN: 1001-8255, 2001 * |
Also Published As
Publication number | Publication date |
---|---|
WO2011108009A2 (en) | 2011-09-09 |
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