WO2012148148A3 - Novel zinc azide complex and a process for preparing tetrazole derivatives using the same - Google Patents

Novel zinc azide complex and a process for preparing tetrazole derivatives using the same Download PDF

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Publication number
WO2012148148A3
WO2012148148A3 PCT/KR2012/003135 KR2012003135W WO2012148148A3 WO 2012148148 A3 WO2012148148 A3 WO 2012148148A3 KR 2012003135 W KR2012003135 W KR 2012003135W WO 2012148148 A3 WO2012148148 A3 WO 2012148148A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
zinc azide
tetrazole derivatives
azide complex
novel zinc
Prior art date
Application number
PCT/KR2012/003135
Other languages
French (fr)
Other versions
WO2012148148A9 (en
WO2012148148A2 (en
Inventor
Byeong Cheol Kim
Sei Chang Ahn
Hyun Ik Shin
In Sang Lee
Young Keun Kim
Original Assignee
Lg Life Sciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd. filed Critical Lg Life Sciences Ltd.
Publication of WO2012148148A2 publication Critical patent/WO2012148148A2/en
Publication of WO2012148148A3 publication Critical patent/WO2012148148A3/en
Publication of WO2012148148A9 publication Critical patent/WO2012148148A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/06—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Abstract

The present invention relates to a novel zinc azide complex. The present invention also relates to a process for preparing 5-substituted-1H-tetrazole derivatives from nitrile derivatives by using the zinc azide complex. According to the present invention, in particular, pharmaceutically active compounds for treating hypertension or intermediates useful for preparation thereof can be prepared effectively.
PCT/KR2012/003135 2011-04-25 2012-04-24 Novel zinc azide complex and a process for preparing tetrazole derivatives using the same WO2012148148A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0038664 2011-04-25
KR20110038664 2011-04-25

Publications (3)

Publication Number Publication Date
WO2012148148A2 WO2012148148A2 (en) 2012-11-01
WO2012148148A3 true WO2012148148A3 (en) 2013-01-03
WO2012148148A9 WO2012148148A9 (en) 2013-02-14

Family

ID=47072884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/003135 WO2012148148A2 (en) 2011-04-25 2012-04-24 Novel zinc azide complex and a process for preparing tetrazole derivatives using the same

Country Status (2)

Country Link
KR (1) KR101942064B1 (en)
WO (1) WO2012148148A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109761924B (en) * 2019-02-26 2020-09-01 安徽美诺华药物化学有限公司 Improved post-treatment method of valsartan reaction mixed liquid
CN112079788A (en) * 2019-06-13 2020-12-15 安徽美诺华药物化学有限公司 Preparation method of valsartan
CN110467604B (en) * 2019-08-29 2020-09-08 浙江天宇药业股份有限公司 Preparation method of losartan
EP3939967A1 (en) 2020-07-15 2022-01-19 KRKA, d.d., Novo mesto A continuous process for the preparation of (s)-methyl n-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-n-pentanoylvalinate in a flow reactor
CN113501831B (en) * 2021-07-15 2022-11-15 西安近代化学研究所 5-aminotetrazole zinc complex, and synthesis method and application thereof
CN116375687A (en) * 2021-12-22 2023-07-04 浙江华海药业股份有限公司 High-purity losartan potassium and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325248A (en) * 1995-05-26 1996-12-10 Chugoku Kayaku Kk New reagent for synthesizing tetrazole compound and production of tetrazole compound using the same
GB0316546D0 (en) * 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
CN101774975B (en) * 2009-12-25 2012-11-28 中国科学院过程工程研究所 Ionic liquid catalysis ring-closure reaction method

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAPPORTO, P. ET AL.: "Addition of Small Molecules by Zn(II) and Cu(II) Dinuclear Complexes Obtained by an Amino-Phenolic Ligand. Crystal Structures of the Dinuclear Zinc Complex Assembling Butanolate and Azide Anions", INORG. CHEM., vol. 40, 2001, pages 6186 - 6192, XP055238302, DOI: doi:10.1021/ic0105415 *
DEMKO, Z. P. ET AL.: "An Expedient Route to the Tetrazole Analogues of alpha-Amino Acids", ORG. LETT., vol. 4, 2002, pages 2525 - 2527, XP002611922, DOI: doi:10.1021/OL020096X *
DEMKO, Z. P. ET AL.: "Preparation of 5-Substituted 1H-Tetrazoles from Nitriles in Water", J. ORG. CHEM., vol. 66, 2001, pages 7945 - 7960 *
HIMO, F. ET AL.: "Why Is Tetrazole Formation by Addition of Azide to Organic Nitriles Catalyzed by Zinc(II) Salts", J. AM. CHEM. SOC., vol. 125, 2003, pages 9983 - 9987, XP002611921 *

Also Published As

Publication number Publication date
KR101942064B1 (en) 2019-01-24
KR20120120907A (en) 2012-11-02
WO2012148148A9 (en) 2013-02-14
WO2012148148A2 (en) 2012-11-01

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