WO2011099103A1 - 超音波診断装置および内中膜複合体厚の測定方法 - Google Patents
超音波診断装置および内中膜複合体厚の測定方法 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0858—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving measuring tissue layers, e.g. skin, interfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5284—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving retrospective matching to a physiological signal
Definitions
- the present invention relates to an ultrasonic diagnostic apparatus and a method for measuring an intima-media complex thickness using the same.
- IMT Intima-Media Thickness
- IMT is the thickness of the intima-media complex of the carotid vascular wall.
- the intima-media complex is a layer that is visible between the blood vessel lumen and the outer membrane.
- the lumen-intima boundary the boundary between the blood vessel lumen and the intima
- the media adventitia the boundary between the media and the adventitia
- Patent Document 1 discloses a method for automatically measuring the IMT.
- an IMT measurement range is set along the carotid artery, and a maximum thickness (maxIMT) and an average thickness (meanIMT) during this period are measured.
- maximum thickness maxIMT
- meanIMT average thickness
- the conventional ultrasonic diagnostic apparatus has a problem that, when attempting to measure the state of the carotid artery that is a detection target part, it is difficult to perform accurate measurement unless it is a skilled person who has been sufficiently trained.
- the probe when it is intended to measure the state of the carotid artery, the probe must be applied at a position where the center line of the carotid artery can be cut in the vertical direction.
- the diameter of the carotid artery and the thickness of the carotid artery wall are constantly changing as the blood flow flowing inside the carotid artery changes according to the pulsation of the heart. That is, when the operator holds the probe in the correct position, the carotid artery state may not necessarily be the timing to be measured.
- an object of the present invention is to make it possible to measure the state of the carotid artery when the position and timing of a probe capable of accurate measurement are reached.
- the ultrasonic diagnostic apparatus is an ultrasonic diagnostic apparatus to which a probe having a transducer can be connected.
- the ultrasonic diagnostic apparatus drives the probe and transmits ultrasonic waves to a blood vessel of a subject.
- An ultrasonic signal processing unit that performs reception processing for generating a reception signal from reflected ultrasound from the blood vessel of the subject received by the tentacle, a tomographic image processing unit that constructs a tomographic image from the reception signal, and the reception signal
- a boundary detection unit that detects a lumen intima boundary and a medial epicardial boundary of the blood vessel from the tomogram, and a distance between the lumen intima boundary and the medial epicardial boundary detected by the boundary detection unit Based on the characteristics on the signal or image information at the position of the detected luminal intima boundary and intima epicardial boundary of the received signal or the tomographic image, the blood vessel wall thickness calculating unit to calculate as the wall thickness value
- the signal feature includes at least one of signal strength and signal strength distribution.
- the feature on the image information includes at least one of luminance, luminance distribution, and shape.
- the received signal is a length of the blood vessel from a feature on the signal or image information at the position of the detected intima boundary and intima epicardial boundary of the received signal or the tomogram. Judgment whether or not it is acquired from the vicinity of a cross section passing through the center in the axial direction, or calculation of an evaluation value representing the probability that the received signal is acquired from the vicinity of a cross section passing through the center in the long axis direction of the blood vessel Further comprising a blood vessel center determining unit, wherein the reliability determining unit determines that the received signal is acquired from the vicinity of a cross section passing through the center of the long axis of the blood vessel, or It is determined that the reliability of the vascular wall thickness value is high when the evaluation value exceeds a predetermined reference value, or the reliability of the vascular wall thickness value is higher as the evaluation value is higher To do.
- the blood vessel center determination unit is configured to display a lumen-intima boundary on a signal or image information of the detected lumen-intima boundary and media-epicardium boundary of the received signal or the tomogram. And whether or not the received signal is acquired from the vicinity of a cross section passing through the center in the long axis direction of the blood vessel judge. With this configuration, it is possible to appropriately determine that the received signal is acquired from the vicinity of the cross section passing through the center of the blood vessel in the long axis direction, and a highly reliable measurement value can be obtained.
- the blood vessel center determination unit further includes a lumen on a signal or image information of the position of the detected lumen-intima boundary and media-epicardium boundary of the received signal or the tomographic image.
- a cross section through which the received signal passes through the center in the longitudinal direction of the blood vessel by evaluating the length of the portion where the signal intensity distribution or luminance distribution peculiar to the intima boundary and the intima boundary is present. It is determined whether it is acquired from the vicinity. With this configuration, it becomes possible to determine more appropriately that the received signal is acquired from the vicinity of the cross section passing through the center of the blood vessel in the long axis direction, and a highly reliable measurement value can be obtained.
- a pulsation detection unit that calculates an evaluation value representing the likelihood, and when the reliability determination unit determines that the pulsation of a blood vessel is correctly captured by the pulsation detection unit, or the evaluation value It is determined that the reliability of the blood vessel wall thickness value is high when the value exceeds a predetermined reference value, or the reliability of the blood vessel wall thickness value is determined to be higher as the evaluation value is higher.
- the pulsation detecting unit detects the pulsation state of the blood vessel from a change in the inner diameter of the blood vessel, and correctly captures the pulsation of the blood vessel when the change in the inner diameter of the blood vessel is a pulse wave shape. It is determined that With this configuration, it is possible to appropriately determine that the pulsation of the blood vessel is correctly captured, and a highly reliable measurement value can be obtained.
- the pulsation detecting unit detects a pulsation state by detecting a feature amount of a change in the inner diameter of the blood vessel.
- the pulsation detecting unit detects a pulsation state based on a correlation between a change waveform of the inner diameter of the blood vessel and a model waveform registered in advance.
- the pulsation detection unit further includes a heartbeat period detection unit that detects a specific timing during a heartbeat, and correctly captures the pulsation of a blood vessel either before or after the detected timing.
- the reliability determination unit is the pulsation detection unit The blood vessel wall thickness when it is determined that the pulsation of the blood vessel is correctly captured either before or after the timing detected by the heartbeat period detection unit, or when the evaluation value exceeds a predetermined reference value It is determined that the reliability of the value is high, or the higher the evaluation value, the higher the reliability of the blood vessel wall thickness value.
- the pulsation detecting unit detects a movement of the tissue of the subject from the received signal to detect a pulsating state
- the heartbeat period detecting unit detects whether the heartbeat period is in the heartbeat from the pulsating state. Detect specific timing.
- the heartbeat detection unit detects the timing from an electrocardiogram waveform.
- the end diastole can be detected with higher accuracy by using the ECG, and a highly reliable measurement value can be obtained.
- the timing detected by the heartbeat period detection unit is the end diastole.
- the timing detected by the heartbeat period detection unit is a timing delayed by a predetermined time from the end diastole.
- the received signal or the tomographic image includes a long-axis cross section of the blood vessel of the subject, or the received signal or the tomographic image is a long axis of the blood vessel of the subject.
- a long-axis determining unit that calculates an evaluation value representing the probability of including a directional cross-section, and the reliability determining unit is configured so that the received signal or the tomographic image is a blood vessel of the subject. It is determined that the blood vessel wall thickness value is highly reliable when it is determined that the long-axis cross section is included, or when the evaluation value exceeds a predetermined reference value, or the evaluation value The higher the is, the higher the reliability of the blood vessel wall thickness value is determined. With this configuration, it can be determined that the received signal or tomographic image includes a cross section in the major axis direction of the blood vessel, so that it can be determined that an appropriate measurement state has been achieved, and a highly reliable measurement value can be obtained.
- the blood vessel wall thickness value is stable from the small degree of time fluctuation of the blood vessel wall thickness value, or the time fluctuation degree of the blood vessel wall thickness value is small. Further comprising a stability determination unit that calculates an evaluation value representing the probability that the blood vessel wall thickness value is stable, and the reliability determination unit is configured to stabilize the blood vessel wall thickness value in the stability determination unit. It is determined that the reliability of the blood vessel wall thickness value is high when the evaluation value exceeds a predetermined reference value, or the higher the evaluation value, the more the blood vessel It is determined that the reliability of the wall thickness value is high. With this configuration, by determining the stability of the vascular wall thickness value from the small degree of temporal variation of the vascular wall thickness value, it is possible to determine that the measurement state is in an appropriate state, and obtain a highly reliable measurement value. be able to.
- the image processing apparatus further includes an image combining unit that combines a determination result by the reliability determination unit and a tomographic image constructed by the tomographic image processing unit, and displays an image combined by the image combining unit.
- the blood vessel center determination processing or the The apparatus further includes a determination criterion determination unit that determines a determination criterion used for the pulsation determination processing, the long axis determination unit, or the stability determination processing.
- the ultrasonic signal processing unit sequentially generates the plurality of reception signals by performing the transmission processing and the reception processing a plurality of times, and the tomogram processing unit generates a plurality of reception signals from the plurality of reception signals.
- the boundary detection unit sequentially detects the lumen intima boundary and medial epicardial boundary from each of the plurality of received signals or the plurality of tomographic images, and the vessel wall thickness
- the calculation unit sequentially calculates the blood vessel wall thickness value from the sequentially detected lumen intima boundary and medial epicardial boundary
- the reliability determination unit calculates the sequentially calculated blood vessel wall thickness value.
- the reliability is sequentially determined, and the control unit determines the vascular wall thickness value as the intima-media thickness based on the determination result of the reliability determination unit, and displays at least the sequentially constructed tomographic images.
- control unit freezes the sequentially displayed tomographic images based on a result determined by the reliability determination unit. With this configuration, an image in an appropriate measurement state can be frozen.
- the tomographic image, the blood vessel wall thickness value, and the determination result of the reliability determination unit as a frame, a frame recording unit that sequentially records, and all or a plurality of frames recorded in the frame recording unit
- An optimal frame selection unit that selects a frame having the highest reliability from the subset, and the control unit stores the calculation result of the blood vessel wall thickness calculation unit in the frame selected by the optimal frame selection unit. Determined as membrane complex thickness.
- control unit freezes the sequentially displayed tomographic images when a predetermined number or more of frames whose reliability of the blood vessel wall thickness value is higher than a predetermined value are recorded in the frame recording unit.
- control unit freezes the tomographic images that are sequentially displayed when a certain number of frames in which the reliability of the blood vessel wall thickness value is higher than a predetermined value are continuously recorded in the frame recording unit.
- the optimum frame selection unit selects a frame having the highest reliability from among the frames whose reliability recorded in the frame recording unit is continuously higher than a predetermined value.
- the intima-media complex thickness measurement method of the present invention performs a reception process for generating a reception signal from reflected ultrasound from a blood vessel of a subject received by a probe, constructing a tomographic image from the reception signal, The lumen intima boundary and medial epicardial boundary of the blood vessel are detected from the received signal or the tomogram, and the interval between the detected lumen intima boundary and medial epicardial boundary is calculated as the thickness of the blood vessel wall.
- the calculation result of the thickness of the blood vessel wall is determined as a measurement value.
- the IMT value can be measured in an appropriate measurement state, and a highly reliable measurement value can be obtained.
- the intima-media complex thickness measurement method of the present invention performs a reception process for generating a reception signal from reflected ultrasound from a blood vessel of a subject received by a probe, constructing a tomographic image from the reception signal, From the received signal or the tomogram, the lumen-intima boundary and the media-epicardium boundary of the blood vessel are detected, and the detected interval between the lumen-intima boundary and the media-media boundary is calculated as the thickness of the blood vessel wall. Detecting the pulsation state of the blood vessel, and receiving the received signal or the tomogram from the feature on the signal or image information at the detected position of the intima boundary and intima boundary of the lumen.
- the signal is acquired from the vicinity of a cross section passing through the center of the long axis direction of the blood vessel, it is determined whether the pulsation of the blood vessel is correctly captured from the pulsation state of the blood vessel, and these received signals are Acquired from the vicinity of the cross section passing through the center of the long axis of the blood vessel.
- the reliability of the thickness of the blood vessel wall is determined from the determination result of whether or not the pulsation of the blood vessel is correctly captured, and the calculation result of the thickness of the blood vessel wall is determined as a measurement value based on the determined result To do. With this configuration, it is possible to improve the determination accuracy that an appropriate measurement state has been achieved, measure the IMT value in an appropriate measurement state, and obtain a highly reliable measurement value.
- the ultrasonic diagnostic apparatus and the IMT measurement method of the present invention the detection of two types of boundaries, ie, the lumen intima boundary and the medial epicardial boundary, and the ability to correctly capture the pulsation of the blood vessel
- the target blood vessel is captured in an appropriate state in IMT measurement, such as how to apply the probe, and at the time suitable for measuring the IMT value in the heartbeat Since the measured IMT value is determined as the measured value, a highly reliable IMT measurement value can be obtained, and the accuracy and operability in diagnosis such as arteriosclerosis are improved.
- Embodiment 1 is a block diagram showing Embodiment 1 of an ultrasonic diagnostic apparatus according to the present invention. It is a detailed block diagram of Embodiment 1 of the present invention.
- A It is a figure explaining the relationship between the scan which caught the blood vessel center, and the depiction of the lumen intima boundary and the medial epicardial boundary, and (b) the scan which does not capture the blood vessel center, the lumen intima boundary, and It is a figure explaining the relationship with the depiction of the media-outer membrane boundary.
- A It is a figure which shows the structure of the carotid artery of a diagnostic object
- (b) It is a figure which shows the internal diameter change waveform of a carotid artery.
- FIG. 3 is a flowchart showing the operation of the first embodiment. It is a figure which shows the internal diameter change waveform of a carotid artery in detail. (A) It is a figure explaining the correlation with the model waveform and internal diameter change waveform of a carotid artery, (b) It is a figure explaining the method of extending a model waveform on a time-axis. (A) It is a figure which shows the structure of the carotid artery of a diagnostic object, (b) It is a figure which shows the internal diameter change waveform of the carotid artery and the timing of the end diastole detected.
- Embodiment 5 of the ultrasonic diagnosing device by this invention 10 is a flowchart showing the operation of the fifth embodiment. It is a figure explaining the structure of the carotid artery of a diagnostic object, and the measurement range of IMT.
- FIG. 1 is a block diagram of an ultrasonic diagnostic apparatus according to Embodiment 1 of the present invention.
- the ultrasonic diagnostic apparatus 101 includes an ultrasonic signal processing unit 2, a tomographic image processing unit 3, a blood vessel wall thickness calculation unit 4, a pulsation detection unit 5, a reliability determination unit 6, a control unit 7, and an image composition. Part 8 is provided.
- the probe 1 has an ultrasonic transducer, transmits ultrasonic waves to the subject through the ultrasonic transducers, receives reflected ultrasonic waves from the subject, and converts them into electrical signals.
- the ultrasonic signal processing unit 2 is configured so that the probe 1 can be attached and detached, and supplies a driving pulse to the ultrasonic transducer of the probe 1 at a predetermined timing. A transmission process is performed to drive the transmission. In addition, an electrical signal is received from the probe 1, and reception processing necessary for constructing an ultrasonic tomographic image, such as amplification and detection of the electrical signal, is performed to generate a reception signal.
- the ultrasonic signal processing unit 2 repeats transmission processing continuously and generates reception signals sequentially. For this reason, the following processing is sequentially performed on the generated reception signal.
- the tomographic image processing unit 3 receives the reception signal generated by the ultrasonic signal processing unit 2, performs coordinate conversion of the received signal, and sequentially constructs a tomographic image that is a two-dimensional image of the ultrasonic image.
- the blood vessel wall thickness calculation unit 4 calculates the thickness of the blood vessel wall of the blood vessel of the subject to be measured.
- the pulsation detection unit 5 detects and determines whether or not the pulsation state of the blood vessel is correctly detected.
- the reliability determination unit 6 determines whether the observation state and the measurement value are reliable as the measurement result, whether the tomographic image processing unit 3, the blood vessel wall thickness calculation unit 4, and the pulse The determination is made based on the measurement / processing result of the motion detector 5.
- the control unit 7 controls each block and determines and stores the measurement result determined by the reliability determination unit 6 as the measured intima complex thickness, or freezes (stills) the image at that time Perform the process.
- the image composition unit 8 is configured to be connectable to the display unit 9, and the display unit to which the measurement result determined by the reliability determination unit 6 and the tomographic image configured by the tomographic image processing unit 3 are connected. 9 so that it can be displayed.
- the display 9 is a monitor connected to the image composition unit 8 and displaying the image signal.
- FIG. 2 is a detailed block diagram of the ultrasonic diagnostic apparatus according to the first embodiment of the present invention.
- FIG. 2 shows the configuration of FIG. 1 in detail, and the configuration described in FIG.
- the blood vessel wall thickness detection unit 4 includes a boundary detection unit 41 and an IMT calculation unit 42.
- the boundary detection unit 41 detects two types of blood vessel boundaries, that is, a lumen inner membrane boundary and a media outer membrane boundary of a blood vessel to be measured in a range including an IMT measurement range (see FIG. 18).
- the IMT calculator 42 calculates the distance between the lumen-intima boundary detected by the boundary detector 41 and the media-epicardium boundary as IMT. At this time, maxIMT is calculated if the maximum value of the distance in the IMT measurement range is taken, and meanIMT is calculated if the average value is taken.
- the present invention is not limited to these.
- the blood vessel center determining unit 31 converts the lumen-intima boundary and the media-endocardial boundary into a tomogram at the position of the blood vessel boundary.
- the probe 1 is applied to the subject by evaluating whether or not the image is clearly depicted and the length of the portion where the lumen-intima boundary and the medial-membrane boundary are clearly depicted in the tomographic image. It is determined whether or not the hit position captures the vicinity of the center of the blood vessel to be measured.
- the pulsation detection unit 5 includes a pulsation information processing unit 51, a pulsation determination unit 52, and a heartbeat period detection unit 53.
- the pulsation information processing unit 51 processes the reception signal generated by the ultrasonic signal processing unit 2 and extracts information for determining whether or not the blood vessel to be measured is pulsating.
- the pulsatility determination unit 52 determines whether or not the blood vessel is pulsating from the information processed and extracted by the pulsation information processing unit 51.
- the heartbeat period detecting unit 53 detects a specific timing in the heartbeat. For example, the end diastole, that is, the timing when the heart dilates after contraction and the blood flow is minimized is detected.
- the first condition is that the cross section of the blood vessel is almost circular. Therefore, in order to correctly measure the thickness of the blood vessel wall, the position where the probe 1 is applied to the subject is near the center of the blood vessel (so-called circular center). It is necessary to determine whether or not the vicinity is captured. This is because the IMT value is calculated as the interval between the luminal intima boundary and the medial epicardial boundary of the blood vessel, which requires that both blood vessel boundaries be clearly depicted.
- the blood vessel center determination unit 31 performs the determination.
- FIG. 3 is a schematic diagram showing the positional relationship between the cross section of the blood vessel and the course of echoes transmitted and received by the probe 1.
- the echo is reflected at a boundary where there is a difference in acoustic impedance, such as a tissue boundary, but is reflected more strongly at an angle close to 90 degrees on the boundary surface, and a clear reflected echo signal is obtained. Therefore, as shown in FIG. 3A, when the position where the probe 1 is applied to the subject captures the vicinity of the center of the blood vessel, that is, when the echo path passes near the center of the blood vessel, the echo is the lumen of the blood vessel. A strong and clear reflected echo is obtained at both boundaries perpendicular to the intima boundary and the media-outer film boundary.
- the position where the probe 1 is applied to the subject is near the center of the blood vessel. Can be determined. Note that the vicinity of the center where the above two types of boundaries are clearly depicted means that the measured length is the center of the blood vessel cross section from the acoustic line of the ultrasonic wave transmitted from the probe 1 (shown by the broken line in FIG. 3). Is equivalent to about 0.5 mm or less, but is not strictly limited.
- the luminance is increased from the blood vessel lumen side to the inner media side of the detected lumen intima boundary position. Whether there is a rise, whether there is a brightness rise from the intima side to the adventitia side of the detected intima-media boundary position, and the detected lumen-intima boundary position and the intima-media boundary It is possible to determine whether the lumen intima boundary and the media intima boundary are clearly depicted in the tomographic image at the position of the blood vessel boundary by evaluating whether there is a drop in brightness between the positions, etc. it can.
- the length of the portion where the lumen inner membrane boundary and the media outer membrane boundary are clearly depicted in the tomographic image is the same as the position where the probe 1 is applied to the subject near the center of the blood vessel. It can be used to determine whether or not it is captured.
- a criterion for determination is that the above-described two kinds of boundaries are clearly depicted in the entire IMT measurement range (see FIG. 18) or in a certain ratio or more. For example, when the IMT measurement range is 1 cm and the above-mentioned certain ratio is 75%, 7.5 mm of 1 cm is a reference for the length for determining that the center of the blood vessel is captured.
- the blood vessel expands and contracts according to the amount of blood flow and the flow velocity flowing through the blood vessel.
- the blood flow velocity is maximized, at which time the inner diameter of the blood vessel is maximized and the thickness of the blood vessel wall is minimized. Since the blood flow is minimized during the diastole of the heart, the inner diameter of the blood vessel is minimized and the thickness of the blood vessel wall is maximized. That is, since the thickness of the blood vessel wall changes in synchronization with the heartbeat, the IMT value also changes depending on the measurement timing.
- the inner diameter once decreases, then increases rapidly, and gradually returns to the original diameter. More precisely, in the case of a normal blood vessel, a peak called Dicrotic peak appears when it gradually returns to the original diameter, and the inner diameter change waveform has two positive peaks.
- the heartbeat detection unit 53 detects the timing.
- the pulsatility determination unit 52 does not detect whether or not the blood vessel is pulsating, but determines whether or not the probe contact or the like is in a state where the blood vessel information can be correctly measured. Judgment is based on whether movement is correctly captured.
- FIG. 5 is a flowchart showing a typical operation of the first embodiment.
- step S101 the ultrasonic signal processing unit 2 performs transmission control and reception control of ultrasonic signals, and drives the probe 1 to transmit ultrasonic waves and reflect them from the subject to reflect the probe 1.
- the reflected ultrasonic waves received in step 1 are subjected to signal processing in the same manner as a general ultrasonic diagnostic apparatus to generate reception signals (reception echo data).
- step S102 the tomographic image processing unit 3 processes the received echo data to construct a tomographic image.
- the tomographic image data generated here covers a variety of subjects such as the internal organs of the subject.
- the received echo data output from the ultrasonic signal processing unit 2 is also sent to the blood vessel wall thickness detection unit 4 and the pulsation detection unit 5.
- step S103 the boundary detection unit 41 of the blood vessel wall thickness detection unit 4 determines whether the boundary detection unit 41 is based on the amplitude or phase of the received echo signal output from the ultrasonic signal processing unit 2 and the lumen intima boundary of the blood vessel. And detect the epicardial border.
- the ROI is normally set in correspondence with the IMT measurement range (see FIG. 18).
- the IMT calculation unit 42 calculates the thickness of the intima, that is, the IMT value, from the position information of the lumen intima boundary and the media-to-media epicardial boundary detected by the boundary detection unit 41.
- the blood vessel center determination unit 31 starts from the tomographic image processing unit 3 in step S105. From the tomogram and the boundary detection result, it is determined whether or not the received signal of the blood vessel currently captured by the probe is a received signal near the center of the blood vessel.
- the reception signal output from the ultrasonic signal processing unit 2 is also sent to the pulsation detection unit 5.
- step S106 the pulsation detecting unit 5 detects the pulsation of the target blood vessel, and determines whether the waveform correctly captures the pulsation of the blood vessel.
- the pulsation information processing unit 51 sets measurement points A and B on the front wall and the rear wall of the target blood vessel, and analyzes the amplitude and phase of the received echo data. By doing so, the movement of the measurement points A and B is tracked.
- the artery repeatedly contracts and dilates due to the heartbeat. Therefore, the distance between the measurement points A and B moves periodically as shown in FIG. 4B, and this is detected as a blood vessel inner diameter change waveform.
- the inner diameter change waveform of the blood vessel can be obtained by a simple operation simply by placing the probe on the subject. Can do.
- the pulsatility determination unit 52 evaluates whether or not the inner diameter change waveform obtained by the pulsation information processing unit 51 correctly captures the pulsation of the blood vessel, and whether or not the inner diameter change waveform is a pulse wave. Determine by doing.
- a method (1) a method that focuses on a simple feature amount of the inner diameter change waveform and a method (2) a method that focuses on the degree of coincidence with the reference (model) waveform of the inner diameter change waveform can be considered.
- the above parameters are the waveforms shown in FIG. 6. As an example, when Amax is less than 1 mm, Amin is a negative value, TR is about 1 second, and Tmin ⁇ Tmax, it has been experimentally confirmed that pulsatility can be determined. Yes.
- a reference model waveform is created, and the degree of matching between the waveform and the measured inner diameter change waveform is determined by calculating a correlation coefficient.
- the model waveform is created by collecting data on the inner diameter waveforms of a plurality of people.
- the correlation coefficient between the model waveform and the measured inner diameter change waveform is calculated.
- the model waveform and the measurement waveform are expanded and contracted on the time axis, and the correlation coefficient is calculated with the same time length.
- FIG. 7B shows a case where the measured waveform length is longer than the model waveform length. Since the period of the model waveform and the inner diameter change waveform of a subject, that is, one heartbeat period is almost the same, it is expanded and contracted in the time direction as shown in FIG.
- the determination is based on the evaluation of the waveform.
- the measurement timing is important as described above.
- the heartbeat period detection unit 53 tracks the movement state of the measurement point A associated with the pulsation at the measurement points A and B set on the front wall and the rear wall of the target blood vessel. And the amount of change, that is, the differential waveform TA ′ is obtained.
- This differential waveform TA ' is used as a pseudo R-wave timing so that it can be referred to as an IMT measurement timing.
- the timing near the end diastole is when the IMT value is maximized, and the IMT value can be measured at the optimum timing by detecting the end diastole timing.
- the ideal timing at which the IMT value reaches the maximum value is a timing delayed by a predetermined time from the end diastole (corresponding to the timing of the R wave in the electrocardiogram) as shown in FIG.
- the timing for measuring the IMT value during one heartbeat does not necessarily have to be at the end of diastole, and it is versatile if it can detect any timing according to the processing delay time and processing method. Will increase.
- FIG. 10 shows waveforms when blood vessels are correctly captured and not correctly captured in diagnosis.
- the end diastole is detected at each point from a to e, but points a, b, and c are points that do not correctly capture blood vessels, and d and e are points that correctly capture blood vessels.
- d and e are points at which both pulsatility determination and end diastole detection by the evaluation of the inner diameter change waveform are correctly detected.
- the blood vessel is searched for in the diagnosis. Even when a point that is not at the end of diastole is detected, such as when the probe is moved, it is determined that the blood vessel is not correctly captured by evaluating the inner diameter change waveform.
- the pulsatility determination unit 52 refers to both the evaluation result of the inner diameter change waveform detected by the pulsation information processing unit 51 and the timing of the end diastole detected by the heartbeat period detection unit 53, so that the blood vessel The accuracy of determining that the pulsation, that is, the blood vessel is correctly captured by the probe is improved.
- the IMT value calculated by the IMT calculation unit 42 is evaluated by the reliability determination unit 6 by evaluating the pulsatility detected and determined by the blood vessel center determination unit 31 and the pulsation detection unit 5 in step S107.
- step S108 it is determined whether the measurement result is valid. If it is determined that the IMT value is reliable, the control unit 7 determines the IMT value as an IMT measurement value in step S109. If it is determined that there is no reliability, the process returns to step S101 to continue the measurement.
- the reliability determination unit 6 performs a process of freezing the image via the control unit 7, thereby obtaining a reliable measurement result and its vascular tomographic image in the IMT measurement. Obtainable.
- the determination by the reliability determination unit 6 is to determine the reliability of the IMT value based on whether or not the currently grasped blood vessel to be diagnosed is in an appropriate state for determining the IMT measurement result. The reliability is determined based on the determination result at 31 and the determination result at the pulsatility determination unit 52.
- the reliability determining unit 6 determines that the reliability of the IMT value is high. Further, when the pulsation determination unit 52 determines that the pulsation of the blood vessel is correctly captured, the reliability determination unit 6 determines that the reliability of the IMT value is high. When these are satisfied, the reliability determination unit 6 determines that there is sufficient reliability to determine the IMT measurement result.
- the blood vessel center determining unit 31 calculates an evaluation value indicating the probability that the position of the probe 1 captures the vicinity of the center of the blood vessel, and the pulsatility determining unit 52 correctly captures the pulsation of the blood vessel.
- An evaluation value representing the likelihood is calculated, and the reliability determination unit 6 evaluates the reliability of the IMT value from the evaluation value calculated by the blood vessel center determination unit 31 and the evaluation value calculated by the pulsatility determination unit 52. May be calculated, and it may be determined that there is reliability when the evaluation value exceeds a predetermined reference value.
- the range of the value determined to be reliable is larger than the reference value, and the range of the value determined to have high reliability.
- the range of the predetermined value determined to be reliable may be larger or smaller than the reference value. Therefore, depending on how the evaluation value is taken, it is determined that the reliability is determined when the evaluation value is smaller than the reference value, and the reliability is determined when the evaluation value is larger than the reference value. There is a case. In either case, if the evaluation value is within a predetermined value range that is determined to be reliable, it is determined to be reliable.
- the evaluation value calculated by the blood vessel center determination unit 31 increases as the length of the portion in which the above-described lumen-intima boundary and media-media outer-film boundary are clearly depicted is larger.
- the evaluation value may be determined such that the evaluation value increases as the rise or fall of the luminance of the tomographic image in the vicinity of the detected lumen intima boundary position or intima-epicardial boundary position increases.
- the evaluation value calculated by the pulsatility determination unit 52 may be determined so that, for example, the larger the correlation between the above-described model waveform and the measured inner diameter change waveform is, the larger the evaluation value is.
- the determination can be made only by the result of the blood vessel center determination unit 31, or can be determined only by the result of the pulsatility determination unit 52. By referring to both determination results, the determination accuracy can be improved. On the other hand, since only one of the determinations can be made depending on the diagnosis situation, it is possible to select the software as appropriate in accordance with the use of the apparatus, the cost, the quantity, and the like.
- step S110 the image synthesizing unit 8 synthesizes the IMT measurement value determined based on the result determined by the reliability determining unit 6 and the tomographic image constructed by the tomographic image processing unit 3, and displays the display unit. By outputting to 9, the operator can check the diagnostic image and the measurement result.
- step S105 the blood vessel center determination process (step S105) and the pulsatility determination process (step S106) are executed in this order, but these are in no particular order.
- the blood vessel center determining unit 31 uses the tomographic image constructed by the tomographic image processing unit 3 and the blood vessel boundary detected by the boundary detecting unit 41 to position the probe 1 on the subject. Is configured to directly input the received echo signal output from the ultrasonic signal processing unit 2 to the blood vessel center determination unit 31 without passing through the tomographic image processing unit 3.
- the amplitude of the received echo signal output from the ultrasonic signal processing unit 2 can be used instead of the tomographic image.
- the determination can be performed without depending on the settings and parameters when constructing the tomographic image.
- Embodiment 2 Next, Embodiment 2 will be described with reference to FIG. A typical operation flowchart is the same as that shown in FIG.
- FIG. 11 is a block diagram of the ultrasonic diagnostic apparatus according to Embodiment 2 of the present invention.
- the ultrasonic diagnostic apparatus 102 includes an ultrasonic signal processing unit 2, a tomographic image processing unit 3, a blood vessel wall thickness calculation unit 4, a pulsation detection unit 50, a reliability determination unit 6, a control unit 7, and an image configuration. Part 8 is provided.
- pulsation detection using ECG will be described.
- the ECG signal processing unit 54 is provided in the pulsation detection unit 50, the electrocardiogram signal of the subject detected by the ECG pad 12 is amplified, the signal waveform is analyzed, and an R wave signal or the like is detected.
- the detection hand unit 55 detects the heartbeat timing detected by the ECG signal processing unit 54. As described in the first embodiment, in the IMT measurement, the timing at which the IMT value becomes maximum is detected based on the R wave timing (end diastole).
- the heartbeat timing including the end diastole can be accurately detected by using ECG, the accuracy of pulsatility determination is improved.
- the first embodiment and the second embodiment are one of the main differences in the presence or absence of ECG.
- ECG electrocardiogram signal
- an electrocardiogram signal is directly observed compared with the configuration in which the end diastole is indirectly detected from the change in the inner diameter of the blood vessel of the end diastole detection unit 53 described in the first embodiment.
- the end timing can be detected. Therefore, although it has the effect of improving the measurement accuracy of IMT, ECG requires measurement by attaching an ECG pad to the wrist, ankle, and chest of the subject (patient), and the measurement must be at rest.
- the ECG is unnecessary in the first embodiment, the IMT value can be measured simply by applying an ultrasonic probe to the carotid artery in the patient's neck. Therefore, the ECG of the second embodiment is used. There is an effect that the ease and operability in measurement are further improved.
- the first embodiment it is effective to use when priority is given to measurement operability
- the second embodiment it is effective to use when measurement accuracy should be further improved.
- the ultrasonic diagnostic apparatus since the ultrasonic diagnostic apparatus according to the configuration of the first embodiment can easily measure the initial diagnosis whether there is a possibility of a circulatory system disease or the like, It is good to use when diagnosis is required without choosing a place.
- the ultrasonic diagnostic apparatus may be used when a more accurate diagnosis is necessary in a place where the diagnosis environment is in place for a circulatory system disease.
- FIG. 12 is a block diagram of an ultrasonic diagnostic apparatus according to the third embodiment of the present invention
- FIG. 13 is a flowchart showing a typical operation of the third embodiment of the present invention.
- the ultrasonic diagnostic apparatus 103 includes an ultrasonic signal processing unit 2, a tomographic image processing unit 3, a blood vessel wall thickness calculation unit 4, a pulsation detection unit 5, a reliability determination unit 6, a control unit 7, and an image.
- a synthesis unit 8, a long axis determination unit 20, a stability determination unit 21, and a blood vessel center determination unit 31 are provided.
- the difference from the first embodiment is that a long axis determination unit 20 and a stability determination unit 21 are provided, and the reliability determination unit 6 uses the determination results of the long axis determination unit 20 and the stability determination unit 21. .
- the probe 1 is equivalent to that of the first embodiment, and the processing performed by the ultrasonic signal processing unit 2, the tomographic image processing unit 3, the blood vessel center determination unit 31, the blood vessel wall thickness detection unit 4, and the pulsation detection unit 5 is as follows. This is equivalent to the first embodiment.
- steps S201, S202, S203, and S204 processing is performed in the same manner as steps S101, S102, S103, and S104 of the first embodiment, respectively.
- the tomographic image information output from the tomographic image processing unit 3 is also sent to the long axis determination unit 20.
- the long axis determination unit 20 determines whether the acquired tomographic image information includes a cross section in the long axis direction of the blood vessel based on the luminance information included in the tomographic image information.
- the tomographic image information includes a cross section in the long axis direction of the blood vessel.
- the tomographic image information includes a cross section in the major axis direction of the blood vessel based on the luminance distribution of the tomographic image information in the IMT measurement range and the ratio of the range determined to be the major axis direction of the blood vessel in the IMT measurement range. It is also possible to determine the degree of accuracy (not a binary value indicating whether or not the long axis is included).
- the boundary detection result and blood vessel wall thickness information output from the blood vessel wall thickness detection unit 4 are also sent to the stability determination unit 21.
- the stability determination unit 21 determines the movement of the probe 1 and the test from the time variation of the IMT value calculated by the IMT calculation unit 42 based on the boundary detected by the boundary detection unit 41 in a predetermined period. The degree of fluctuation of the IMT value due to disturbance such as body movement is obtained, and the stability of the calculated IMT value is determined.
- the timing at which the IMT calculation unit 42 calculates the IMT value is described as the end diastole.
- the IMT value calculated by the IMT calculation unit 42 is sent to the stability determination unit 21 for each heartbeat.
- the stability determination unit 21 accumulates the calculated IMT value for a predetermined heart rate. Then, for example, the difference between the accumulated IMT values is compared with a predetermined value. If the difference is smaller than this, the degree of fluctuation of the IMT value due to the movement of the probe 1 or the movement of the subject is small and calculated. It is determined that the IMT value is stable. Alternatively, the degree of stability of the IMT value is determined (instead of a binary value indicating whether or not it is stable) so that the calculated IMT value is more stable as the difference between the plurality of accumulated IMT values is smaller. You can also.
- steps S205 and S206 processing is performed in the same manner as steps S105 and S106 in the first embodiment, respectively.
- step S207 the reliability determination unit 6 performs (a) a determination result of the long axis determination unit 20, (b) a determination result of the blood vessel center determination unit 31, and (c) a pulsation information processing unit 51 and a heartbeat period detection unit.
- the IMT calculation unit 42 evaluates the result of determining the pulsation of the blood vessel by the pulsatility determination unit 52 and (d) the determination result of the stability determination unit 21. The reliability of the calculated IMT value is determined, and it is determined in step S208 whether the measurement result is valid.
- control unit 7 determines the IMT value as an IMT measurement value in step S209. At this time, a process of freezing the image may be performed. If it is determined that there is no reliability, the process returns to step S201 to continue the measurement.
- the long axis determination unit 20 converts the tomographic image information into the long axis direction of the blood vessel in the IMT measurement range as described above, for example.
- the reliability determination unit 6 determines that the reliability of the IMT value is high.
- the stability determination unit 21 determines that the degree of fluctuation of the IMT value is stable below a predetermined value as described above, the reliability determination unit 6 has high reliability of the IMT value. Is determined.
- the reliability determination unit 6 determines that the reliability of the IMT value is high. When all or a predetermined number of the above four determinations (1) to (4) are satisfied, the reliability determination unit 6 determines that there is sufficient reliability to determine the IMT measurement result.
- the long axis determination unit 20 calculates a degree representing the probability that the above-described tomographic image information includes a cross section in the long axis direction of the blood vessel as an evaluation value
- the stability determination unit 21 The degree of stability of the IMT value is calculated as an evaluation value. Further, as in the first embodiment, (7) the probability that the position of the probe 1 captures the vicinity of the center of the blood vessel in the blood vessel center determination unit 31 is determined.
- the pulsatility determination unit 52 calculates an evaluation value indicating the probability of correctly capturing the pulsation of the blood vessel, and the reliability determination unit 6 calculates the above (5) to (8
- the evaluation value representing the reliability of the IMT value may be calculated from the four evaluation values, and the reliability may be determined when the evaluation value exceeds a predetermined reference value.
- step S210 the image combining unit 8 combines the IMT measurement value determined by the reliability determining unit 6 with the tomographic image constructed by the tomographic image processing unit 3, and the determination result of the reliability determining unit 6 is displayed. It is combined with the tomographic image constructed by the tomographic image processing unit 3 and output to the display unit 9. Thereby, since it can be visually confirmed whether or not the measurement can be performed with a cross section passing through the blood vessel center in the major axis direction of the blood vessel, the operator can check the measurement result and the reliability thereof, and the operability is improved.
- the determination result of the reliability determination unit 6 can be displayed alone using characters or symbols without being combined with the tomographic image.
- the determination result of the long axis determination unit 20 the determination result of the blood vessel center determination unit 31, the determination result of the pulsatility determination unit 52, and the determination result of the stability determination unit 21 can be displayed on the display 9. is there.
- the user can know why the reliability is low, which leads to improvement in operability.
- the long axis determination unit 20 determines whether the acquired tomographic image information includes a cross section in the long axis direction of the blood vessel, and uses the result for reliability determination.
- the accuracy of determining whether the received signal is obtained from the central cross section in the long axis direction of the blood vessel is improved, and the reliability of IMT measurement is improved.
- the stability determination unit 21 determines the stability from the degree of fluctuation of the IMT value, and uses the result for reliability determination, so that the influence of the movement of the probe 1 and the movement of the subject is small.
- the value can be adopted as a measurement value, and the accuracy of IMT measurement is improved.
- the long axis determination unit 20 determines whether the tomographic image information acquired using the tomographic image information transmitted by the tomographic image processing unit 3 includes a long axis direction cross section of the blood vessel of the subject.
- the blood vessel center determination unit 31 determines whether the received signal is acquired from the central cross section in the long axis direction of the blood vessel using the tomographic image information transmitted by the tomographic image processing unit 3. It is also possible to use the amplitude of the received echo signal output from the ultrasonic signal processing unit 2. As a result, the determination can be performed without depending on the settings and parameters when constructing the tomographic image.
- step S211 the long axis determination process (step S211), the stability determination process (step S212), the blood vessel center determination process (step S205), and the pulsatility determination process (step S206) are executed in this order. But these are out of order.
- FIG. 14 is a block diagram of an ultrasonic diagnostic apparatus according to Embodiment 4 of the present invention
- FIG. 15 is a flowchart showing typical operations of Embodiment 4 of the present invention.
- the ultrasonic diagnostic apparatus 104 includes an ultrasonic signal processing unit 2, a tomographic image processing unit 3, a blood vessel wall thickness calculation unit 4, a pulsation detection unit 5, a reliability determination unit 6, a control unit 7, and an image.
- a synthesis unit 8, a long axis determination unit 20, a stability determination unit 21, a blood vessel center determination unit 31, and a determination criterion determination unit 22 are provided.
- a difference from the third embodiment is that a determination criterion determination unit 22 is provided that makes the determination criteria of blood vessel center determination, pulsatility determination, long axis determination, and stability determination variable according to the characteristics of the luminance signal in the ROI. It is a point.
- the probe 1 is equivalent to that of the first embodiment, and the processing performed by the ultrasonic signal processing unit 2, the tomographic image processing unit 3, the blood vessel center determination unit 31, the blood vessel wall thickness detection unit 4, and the pulsation detection unit 5 is as follows. This is equivalent to the first embodiment. Further, the processes of the long axis determination unit 20 and the stability determination unit 21 are the same as those in the third embodiment.
- steps S301, S302, S303, and S304 processing is performed in the same manner as steps S101, S102, S103, and S104 of the first embodiment, respectively.
- the determination criterion determination unit 22 When the trigger is activated by the control signal from the control unit 7 in step S313, the determination criterion determination unit 22 obtains the tomographic image information obtained by the tomographic image processing unit 3 and the detection result obtained from the boundary detection unit 41 in step S314. The value indicating the characteristic of the luminance signal near the boundary is calculated. In accordance with the feature amount, a determination criterion is determined by changing predetermined values used for determination by the long axis determination unit 20, the stability determination unit 21, the blood vessel center determination unit 31, and the pulsatility determination unit 52.
- steps S311, S312, S305, and S306 processing is performed in the same manner as steps S211 and S212 of the third embodiment and steps S105 and S106 of the first embodiment, respectively.
- step S307 the reliability determination unit 6 determines the determination results of the long axis determination unit 20, the stability determination unit 21, the blood vessel center determination unit 31, and the pulsatility determination unit 52 using the threshold values determined by the determination criterion determination unit 22. Thus, the reliability of the calculated IMT value is determined.
- the determination criterion determination unit 22 blood vessel center determination, pulsation determination, long axis determination, and stability determination can be performed according to the tissue properties of the subject, so that IMT measurement Improves accuracy and reliability.
- step S308 whether the reliability of the IMT value determined by the reliability determination unit 6 is appropriate as a measurement result is determined. If it is determined that the IMT value is reliable, the control unit 7 determines the IMT value as an IMT measurement value in step S309. At this time, a process of freezing the image may be performed. If it is determined that there is no reliability, the process returns to step S301 to continue the measurement.
- step S310 the same processing as in step S210 of the third embodiment is performed.
- the control signal from the control unit 7 is used as a trigger.
- the long axis determination unit 20 determines that the acquired tomographic image includes a long-axis cross section of the blood vessel. Timing may be used as a trigger. Thereby, IMT measurement can be performed smoothly after acquiring a tomographic image in the long axis direction.
- an input unit may be provided, and an input from the user may be used as a trigger. Thereby, it is also possible to make a user who has sufficient knowledge about IMT measurement select a determination criterion.
- step S311 the long axis determination process (step S311), the stability determination process (step S312), the blood vessel center determination process (step S305), and the pulsatility determination process (step S306) are executed in this order. But these are out of order.
- FIG. 16 is a block diagram of the ultrasonic diagnostic apparatus according to the fifth embodiment of the present invention. Note that the blocks given the same reference numerals as those in FIG. 2 are the same as those in the first embodiment and will not be described.
- the reliability determination unit 60 determines the degree of reliability of the observation state and the measurement value, that is, how reliable the measurement result is, and the tomographic image processing unit 3, blood vessel The determination is made based on the measurement / processing results of the wall thickness calculator 4 and the pulsation detector 5.
- the frame recording unit 61 records the reliability determined by the reliability determination unit 60 as a frame together with the IMT value calculated by the IMT calculation unit 42 and the tomographic image formed by the tomographic image processing unit 3.
- the optimum frame selection unit 62 selects the frame with the highest reliability from all or a subset of the frames recorded in the frame recording unit 61.
- the control unit 70 controls each block and, based on the result determined by the reliability determination unit 60, determines the measurement result of the frame selected by the optimum frame selection unit 62 as a measurement value or freezes the image.
- the measurement result and the tomographic image of the selected frame are controlled to be displayed.
- the image composition unit 80 is configured to be able to connect the display unit 9 and synthesizes the measurement result of the frame selected by the optimum frame selection unit and the tomographic image so that the display unit 9 can be displayed.
- FIG. 17 is a flowchart showing a typical operation of the fifth embodiment.
- the operation of the pulsation detection unit 5 including the pulsatility determination unit 52 and the heartbeat period detection unit 53 is the same as that of the first embodiment.
- steps S401, S402, S403, S404, S405, and S406, processing is performed in the same manner as steps S101, S102, S103, S104, S105, and S106 of the first embodiment, respectively.
- the reliability determination unit 60 evaluates the pulsatility detected and determined by the blood vessel center determination unit 31 and the pulsation determination unit 52, thereby calculating the IMT calculated by the IMT calculation unit 42.
- the reliability of the value is determined, and the reliability indicating the degree of validity as the measurement result is determined.
- an evaluation value representing the probability that the position of the probe 1 captures the vicinity of the center of the blood vessel is calculated by the blood vessel center determining unit 31, and the pulsation determining unit 52 correctly captures the pulsation of the blood vessel.
- An evaluation value representing the probability is calculated, and the reliability determination unit 60 determines that the reliability of the calculated IMT value is higher as these evaluation values are higher.
- step S415 the determined reliability is recorded as a frame in the frame recording unit 61 together with the IMT value calculated by the IMT calculating unit 42 and the tomographic image formed by the tomographic image processing unit 3.
- Step S416 will be described later.
- step S417 the optimum frame selection unit 62 reads out the frame recorded in the frame recording unit 61 according to an instruction from the control unit 7, and the frame having the highest reliability is selected from all or a subset thereof.
- the control unit 7 determines the IMT value of the selected frame as the IMT measurement value.
- An example of a specific timing at which the control unit 7 gives the instruction is when an image is frozen through the control unit 7 by a user operation or a determination by a reliability determination unit 60 described later.
- the reliability determination unit 60 can be configured to perform a process of freezing the image via the control unit 7 when a certain condition is satisfied. Specifically, when a certain number of frames having a reliability higher than a predetermined value are recorded in the frame recording unit 61, or when a certain number of frames having a reliability higher than the predetermined value are continuously recorded in the frame recording unit 61. Also, freeze it. In particular, in the latter case, it can be said that continuous frames with high reliability can be measured stably and appropriately, and the optimum frame selection unit 62 selects the frame with the highest reliability from the continuous frames. Is desirable. If the freeze condition is not satisfied, the process returns to step S401 to continue the measurement.
- step S405 the blood vessel center determination process (step S405) and the pulsatility determination process (step S406) are executed in this order, but these are in no particular order.
- the determination can be made only by the result of the blood vessel center determination unit 31, or the determination can be made only by the result of the pulsatility determination unit 52. Refer to both determination results.
- the ultrasonic diagnostic apparatus 105 is configured to include the long axis determination unit 20 and the stability determination unit 21 described in the third embodiment, and the reliability determination unit 60 includes the blood vessel center determination unit 31 and the pulsatility determination.
- the determination result of the long axis determination unit 20 or the stability determination unit 21 may also be used to determine the reliability of the IMT value calculated by the IMT calculation unit 42.
- the reliability determination unit 60 in addition to the evaluation value indicating the probability that the position of the probe 1 captures the vicinity of the center of the blood vessel and the evaluation value indicating the probability of correctly capturing the pulsation of the blood vessel, the long axis determination unit 20 calculates an evaluation value indicating the probability that the tomographic image information includes the long-axis cross section of the blood vessel, and the stability determination unit 21 calculates an evaluation value indicating the degree of stability of the IMT value.
- the reliability determination unit 60 determines that the reliability of the IMT value is higher as these four evaluation values are higher. Since the evaluation value calculation method in the long axis determination unit 20 and the stability determination unit 21 is the same as the content described in the third embodiment, the description is omitted. As a result, the reliability determination performance can be further improved.
- the ultrasound diagnostic apparatus 105 is configured to include the determination criterion determination unit 22 described in the fourth embodiment, and the long axis determination unit 20 and the stability determination unit 21 are triggered by a control signal from the control unit 7 or the like.
- the determination reference can also be determined by changing a predetermined value used for determination by the blood vessel center determination unit 31 and the pulsatility determination unit 52. In this case, the operation and the effect of the determination criterion determination unit 22 are the same as those in the fourth embodiment, and the description thereof will be omitted.
- step S410 the image synthesizing unit 80 synthesizes the IMT measurement value and the tomographic image of the frame selected by the optimum frame selecting unit 62 determined based on the result determined by the reliability determining unit 60, and displays them. By outputting to the device 9, the operator can check the diagnostic image and the measurement result.
- the pulsation detecting unit 50 is provided using the ECG pad 12 instead of the pulsation detecting unit 5 as in the second embodiment.
- the difference from FIG. 16 and the characteristics of each are the same as the relationship between the first embodiment and the second embodiment, and thus detailed description is omitted.
- the ultrasonic diagnostic apparatus and the intima-media complex thickness (IMT) measurement method measures a target blood vessel at an appropriate state and timing in IMT measurement, such as how to apply a probe And the IMT value at that time is determined as the measurement value, so that a highly reliable IMT measurement value can be obtained. Therefore, it has an effect of improving accuracy and operability in diagnosis of arteriosclerosis and the like, and is useful as an ultrasonic diagnostic apparatus and an IMT measurement method using the same.
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Abstract
Description
図1は本発明の実施の形態1に係る超音波診断装置のブロック図である。本実施の形態の超音波診断装置101は、超音波信号処理部2、断層像処理部3、血管壁厚算出部4、拍動検出部5、信頼性判定部6、制御部7および画像合成部8を備えている。
・ 最大振幅、最小振幅:それぞれ図6のAmax, Amin
・ 最大振幅(Amax)になるタイミング:Tmax
・ 最小振幅(Amin)になるタイミング:Tmin
・ 一心拍周期:TR
次に実施の形態2について図11を用いて説明する。なお、典型的な動作のフローチャートは図5と同様になる。
次に、図12と図13を用いて、本発明の実施の形態3について説明する。図12は本発明の実施の形態3に係る超音波診断装置のブロック図、図13は本発明の実施の形態3の典型的な動作を表すフローチャートである。
次に、図14と図15を用いて、本発明の実施の形態4について説明する。図14は本発明の実施の形態4に係る超音波診断装置のブロック図、図15は本発明の実施の形態4の典型的な動作を表すフローチャートである。
本発明の実施の形態5に係る超音波診断装置のブロック図である図16を用いて実施の形態5に係る超音波診断装置105について説明する。なお、図2と同じ符号を付与したブロックは実施の形態1と同等であり、説明を割愛する。
2 超音波信号処理部
3 断層像処理部
4 血管壁厚算出部
5 拍動検出部
6 信頼性判定部
7 制御部
8 画像合成部
9 表示器
10 血管
11 被検体皮膚表面
12 ECGパッド
20 長軸判定部
21 安定性判定部
22 判定基準決定部
31 血管中心判定部
41 境界検出部
42 IMT算出部
50 拍動検出部
51 拍動情報処理部
52 拍動性判定部
53 心拍期検出部
54 ECG信号処理部
55 心拍期検出部
60 信頼性判定部
61 フレーム記録部
62 最適フレーム選択部
70 制御部
80 画像合成部
101、102、103、104、105 超音波診断装置
Claims (27)
- 振動子を有する探触子が接続可能な超音波診断装置であって、
前記探触子を駆動し被検体の血管へ超音波を送信する送信処理及び前記探触子によって受信した前記被検体の血管からの反射超音波から受信信号を生成する受信処理を行う超音波信号処理部と、
前記受信信号から断層像を構築する断層像処理部と、
前記受信信号又は前記断層像より前記血管の内腔内膜境界及び中膜外膜境界を検出する境界検出部と、
前記境界検出部で検出された内腔内膜境界及び中膜外膜境界の間隔を血管壁厚値として算出する血管壁厚算出部と、
前記受信信号又は前記断層像の前記検出された内腔内膜境界及び中膜外膜境界の位置における信号上又は画像情報上の特徴に基づき前記血管壁厚値の信頼性を判定する信頼性判定部と、
前記信頼性判定部の判定結果に基づき前記血管壁厚値を内中膜複合体厚と確定する制御部と
を備える超音波診断装置。 - 前記信号上の特徴は、信号強度および信号強度の分布の少なくとも一方を含む請求項1に記載の超音波診断装置。
- 前記画像情報上の特徴は、輝度、輝度の分布および形体の少なくとも1つを含む請求項1に記載の超音波診断装置。
- 前記受信信号又は前記断層像の前記検出された内腔内膜境界及び中膜外膜境界の位置における信号上又は画像情報上の特徴から、前記受信信号が前記血管の長軸方向の中心を通る断面近傍から取得されているかどうかの判定、または、前記受信信号が前記血管の長軸方向の中心を通る断面近傍から取得されている確からしさを表す評価値の算出を行う血管中心判定部を更に備え、
前記信頼性判定部は、前記血管中心判定部で前記受信信号が前記血管の長軸方向の中心を通る断面近傍から取得されていると判定されたとき、もしくは、前記評価値が所定の基準値を超えているときに前記血管壁厚値の信頼性が高いと判定し、または、前記評価値が高いときほど、前記血管壁厚値の信頼性が高いと判定する請求項1から3のいずれかに記載の超音波診断装置。 - 前記血管中心判定部は、前記受信信号又は前記断層像の前記検出された内腔内膜境界及び中膜外膜境界の信号上又は画像情報上に、内腔内膜境界及び中膜外膜境界に特有の信号強度の分布又は輝度の分布が存在しているかを評価することにより、前記受信信号が前記血管の長軸方向の中心を通る断面近傍から取得されているかを判定する請求項4に記載の超音波診断装置。
- 前記血管中心判定部は更に、前記受信信号又は前記断層像の前記検出された内腔内膜境界及び中膜外膜境界の位置の信号上又は画像情報上に、内腔内膜境界及び中膜外膜境界に特有の信号強度の分布又は輝度の分布が存在している部分の長さを評価することにより、前記受信信号が前記血管の長軸方向の中心を通る断面近傍から取得されているかを判定する請求項5に記載の超音波診断装置。
- 血管の拍動状態を検出して血管の拍動を正しく捉えているかどうかの判定、または、前記血管の拍動状態を検出して血管の拍動を正しく捉えている確からしさを表す評価値の算出を行う拍動検出部を更に備え、
前記信頼性判定部は、前記拍動検出部で血管の拍動を正しく捉えていると判定されたとき、もしくは、前記評価値が所定の基準値を超えているときに前記血管壁厚値の信頼性が高いと判定し、または、前記評価値が高いときほど、前記血管壁厚値の信頼性が高いと判定する請求項1から6のいずれかに記載の超音波診断装置。 - 前記拍動検出部は、血管の内径の変化から前記血管の拍動状態を検出し、前記血管の内径の変化が脈波状であるときに血管の拍動を正しく捉えていると判定する請求項7に記載の超音波診断装置。
- 前記拍動検出部が、前記血管の内径の変化の特徴量を検出することによって拍動状態を検出する請求項8に記載の超音波診断装置。
- 前記拍動検出部が、前記血管の内径の変化波形と、あらかじめ登録されたモデル波形との相関により拍動状態を検出する請求項8に記載の超音波診断装置。
- 前記拍動検出部は、心拍中の特定のタイミングを検出する心拍期検出部を更に有し、検出したタイミングの前後何れか又は両方で血管の拍動を正しく捉えているかどうかの判定、または、検出したタイミングの前後何れか又は両方で血管の拍動を正しく捉えている確からしさを表す評価値の算出を行い、
前記信頼性判定部は、前記拍動検出部で前記心拍期検出部で検出したタイミングの前後何れか又は両方で血管の拍動を正しく捉えていると判定されたとき、もしくは、前記評価値が所定の基準値を超えているときに前記血管壁厚値の信頼性が高いと判定し、または、前記評価値が高いときほど、前記血管壁厚値の信頼性が高いと判定する請求項7から10のいずれかに記載の超音波診断装置。 - 前記拍動検出部が、前記受信信号から前記被検体の組織の動きを検出して拍動状態を検出し、前記心拍期検出部が、前記拍動状態から心拍中の特定のタイミングを検出する請求項11に記載の超音波診断装置。
- 前記心拍期検出部が、心電図の波形から前記タイミングを検出する請求項11に記載の超音波診断装置。
- 前記心拍期検出部で検出するタイミングが、心拡張末期である請求項11から13のいずれかに記載の超音波診断装置。
- 前記心拍期検出部で検出するタイミングが、心拡張末期から所定の時間だけ遅延したタイミングである請求項11から13までのいずれかに記載の超音波診断装置。
- 前記受信信号又は前記断層像が前記被検体の血管の長軸方向断面を含んでいるかどうかの判定、または、前記受信信号又は前記断層像が前記被検体の血管の長軸方向断面を含んでいる確からしさを表す評価値の算出を行う長軸判定部を更に備え、
前記信頼性判定部は、前記長軸判定部で前記受信信号又は前記断層像が前記被検体の血管の長軸方向断面を含んでいると判定されたとき、もしくは、前記評価値が所定の基準値を超えているときに前記血管壁厚値の信頼性が高いと判定し、または、前記評価値が高いときほど、前記血管壁厚値の信頼性が高いと判定する請求項1から15のいずれかに記載の超音波診断装置。 - 前記血管壁厚値の時間変動の度合いの小ささから前記血管壁厚値が安定しているか否かの判定、または、前記血管壁厚値の時間変動の度合いの小ささから前記血管壁厚値が安定している確からしさを表す評価値の算出を行う安定性判定部を更に備え、
前記信頼性判定部は、前記安定性判定部で前記血管壁厚値が安定していると判定されたとき、もしくは、前記評価値が所定の基準値を超えているときに前記血管壁厚値の信頼性が高いと判定し、または、前記評価値が高いときほど、前記血管壁厚値の信頼性が高いと判定する請求項1から16のいずれかに記載の超音波診断装置。 - 前記信頼性判定部による判定結果と前記断層像処理部で構築した断層像とを合成する画像合成部をさらに備え、
前記画像合成部で合成した画像を表示する請求項1から17のいずれかに記載の超音波診断装置。 - 前記被検体の血管からの受信信号または前記断層像処理部で構築された断層像情報と、前記境界検出部で検出した境界とを用いて、前記血管中心判定処理あるいは前記拍動性判定処理あるいは前記長軸判定部あるいは前記安定性判定処理に用いる判定基準を決定する判定基準決定部を更に備える請求項4、7、16および17のいずれかに記載の超音波診断装置。
- 前記超音波信号処理部は前記送信処理および前記受信処理を複数回行うことにより、複数の受信信号を逐次生成し、
前記断層像処理部は前記複数の受信信号から複数の断層像を逐次構築し、
前記境界検出部は、前記複数の受信信号又は前記複数の断層像のそれぞれより前記血管の内腔内膜境界及び中膜外膜境界を逐次検出し、
前記血管壁厚算出部は、前記逐次検出される血管の内腔内膜境界及び中膜外膜境界から前記血管壁厚値を逐次算出し、
前記信頼性判定部は、前記逐次算出される血管壁厚値の信頼性を逐次判定し、
前記制御部は、前記信頼性判定部の判定結果に基づき前記血管壁厚値を内中膜複合体厚と確定し、
少なくとも前記逐次構築される断層像を表示する請求項1から19のいずれかに記載の超音波診断装置。 - 前記制御部は、前記信頼性判定部で判定された結果に基づいて、前記逐次表示される断層像をフリーズさせる請求項20に記載の超音波診断装置。
- 前記断層像、前記血管壁厚値および前記信頼性判定部の判定結果をフレームとして、逐次記録するフレーム記録部と、
前記フレーム記録部に記録された複数のフレームの全てまたはサブセットのうちから最も信頼性が高いフレームを選択する最適フレーム選択部とを更に備え、
前記制御部は、前記最適フレーム選択部で選択されたフレームにおける前記血管壁厚算出部の算出結果を前記内中膜複合体厚と確定する請求項20または21に記載の超音波診断装置。 - 前記制御部は、前記血管壁厚値の信頼性が既定値より高いフレームを一定数以上前記フレーム記録部に記録したときに、前記逐次表示される断層像をフリーズさせる請求項22に記載の超音波診断装置。
- 前記制御部は、前記血管壁厚値の信頼性が既定値より高いフレームを一定数連続して前記フレーム記録部に記録したときに、前記逐次表示される断層像をフリーズさせる請求項22に記載の超音波診断装置。
- 前記最適フレーム選択部は、前記の一定数連続して前記フレーム記録部に記録された信頼性が規定値より高い当該フレームのうちから、最も信頼性が高いフレームを選択する請求項24に記載の超音波診断装置。
- 探触子によって受信した被検体の血管からの反射超音波から受信信号を生成する受信処理を行い、
前記受信信号から断層像を構築し、
前記受信信号又は前記断層像より前記血管の内腔内膜境界及び中膜外膜境界を検出し、
前記検出された内腔内膜境界及び中膜外膜境界の間隔を血管壁の厚みとして算出し、
前記受信信号又は前記断層像の前記検出された内腔内膜境界及び中膜外膜境界の位置における信号上又は画像情報上の特徴に基づき前記血管壁の厚みの信頼性を判定し、
この判定された結果に基づいて前記血管壁の厚みの算出結果を測定値と決定する内中膜複合体厚の測定方法。 - 探触子によって受信した被検体の血管からの反射超音波から受信信号を生成する受信処理を行い、
前記受信信号から断層像を構築し、
前記受信信号又は前記断層像より前記血管の内腔内膜境界と中膜外膜境界を検出し、
前記検出された内腔内膜境界及び中膜外膜境界の間隔を血管壁の厚みとして算出し、
前記血管の拍動状態を検出し、
前記受信信号又は前記断層像の前記検出された内腔内膜境界及び中膜外膜境界の位置における信号上又は画像情報上の特徴から、前記受信信号が前記血管の長軸方向の中心を通る断面近傍から取得されているかを判定し、
前記血管の拍動状態から血管の拍動を正しく捉えているかを判定し、
これらの前記受信信号が前記血管の長軸方向の中心を通る断面近傍から取得されているか及び前記血管の拍動を正しく捉えているかの判定結果から前記血管壁の厚みの信頼性を判定し、
この判定された結果に基づいて前記血管壁の厚み算出結果を測定値と決定する内中膜複合体厚の測定方法。
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- 2010-11-12 CN CN201080036008.3A patent/CN102469987B/zh not_active Expired - Fee Related
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Cited By (10)
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JP2013132390A (ja) * | 2011-12-26 | 2013-07-08 | Toshiba Corp | 超音波診断装置、超音波画像処置装置、医用画像診断装置及び超音波画像処理プログラム |
WO2013124946A1 (ja) * | 2012-02-20 | 2013-08-29 | 株式会社デンソー | 生体の血管径連続測定装置 |
EP2818119A4 (en) * | 2012-02-20 | 2015-10-28 | Fujifilm Corp | ULTRASONIC DIAGNOSIS DEVICE AND ULTRASONIC IMAGE GENERATION METHOD |
JP2014087463A (ja) * | 2012-10-30 | 2014-05-15 | Ge Medical Systems Global Technology Co Llc | 計測装置及びその制御プログラム |
US9339257B2 (en) | 2012-11-29 | 2016-05-17 | General Electric Company | Measuring apparatus and method thereof |
US10992179B2 (en) | 2017-01-23 | 2021-04-27 | Nike, Inc. | Wireless charging system with multi-coil scanning and learning |
WO2019078054A1 (ja) * | 2017-10-17 | 2019-04-25 | 富士フイルム株式会社 | 音響波診断装置および音響波診断装置の制御方法 |
JPWO2019078054A1 (ja) * | 2017-10-17 | 2020-10-22 | 富士フイルム株式会社 | 音響波診断装置および音響波診断装置の制御方法 |
US11170519B2 (en) | 2017-10-17 | 2021-11-09 | Fujifilm Corporation | Acoustic wave diagnostic apparatus and control method of acoustic wave diagnostic apparatus |
US11636616B2 (en) | 2017-10-17 | 2023-04-25 | Fujifilm Corporation | Acoustic wave diagnostic apparatus and control method of acoustic wave diagnostic apparatus |
Also Published As
Publication number | Publication date |
---|---|
EP2535005A1 (en) | 2012-12-19 |
JPWO2011099103A1 (ja) | 2013-06-13 |
CN102469987B (zh) | 2015-11-25 |
JP5754379B2 (ja) | 2015-07-29 |
US9179889B2 (en) | 2015-11-10 |
CN102469987A (zh) | 2012-05-23 |
EP2535005A4 (en) | 2015-08-19 |
US20120179042A1 (en) | 2012-07-12 |
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