WO2011088474A3 - Sulindac and sulindac derivatives and their uses related to infection - Google Patents

Sulindac and sulindac derivatives and their uses related to infection Download PDF

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Publication number
WO2011088474A3
WO2011088474A3 PCT/US2011/021587 US2011021587W WO2011088474A3 WO 2011088474 A3 WO2011088474 A3 WO 2011088474A3 US 2011021587 W US2011021587 W US 2011021587W WO 2011088474 A3 WO2011088474 A3 WO 2011088474A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulindac
infection
derivatives
uses related
methenyl
Prior art date
Application number
PCT/US2011/021587
Other languages
French (fr)
Other versions
WO2011088474A2 (en
Inventor
Natalie Mcdonald
James Murray
Thomas Hodge
Original Assignee
Zirus, Inc.
Perryman, David
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zirus, Inc., Perryman, David filed Critical Zirus, Inc.
Publication of WO2011088474A2 publication Critical patent/WO2011088474A2/en
Publication of WO2011088474A3 publication Critical patent/WO2011088474A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present compositions and methods relate to the use of ((R-S(=0)0-2- R'0.1-arylene)-methenyl-indene-3-yl) acetyl compounds for decreasing infection by a pathogen.
PCT/US2011/021587 2010-01-15 2011-01-18 Sulindac and sulindac derivatives and their uses related to infection WO2011088474A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US33606910P 2010-01-15 2010-01-15
US61/336,069 2010-01-15
US34359410P 2010-04-30 2010-04-30
US61/343,594 2010-04-30
US36980810P 2010-08-02 2010-08-02
US61/369,808 2010-08-02

Publications (2)

Publication Number Publication Date
WO2011088474A2 WO2011088474A2 (en) 2011-07-21
WO2011088474A3 true WO2011088474A3 (en) 2011-12-29

Family

ID=44305023

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/021587 WO2011088474A2 (en) 2010-01-15 2011-01-18 Sulindac and sulindac derivatives and their uses related to infection

Country Status (1)

Country Link
WO (1) WO2011088474A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014026959A1 (en) 2012-08-13 2014-02-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of cystic fibrosis
WO2017083971A1 (en) * 2015-11-16 2017-05-26 University Of Manitoba Compositions and methods for treatment of influenza
PL237474B1 (en) 2017-05-04 2021-04-19 Wyzsza Szkola Medyczna W Bialymstoku New applications of 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl) methylidene]inden-1-yl] acetic acid
WO2021202014A1 (en) * 2020-03-30 2021-10-07 Applied Biology, Inc. Anti-androgen or an androgen receptor antagonist for treatment of a viral respiratory infection
US11338010B2 (en) 2020-03-30 2022-05-24 Suzhou Kintor Pharmaceuticals, Inc. Systems, methods, and kits for diagnostics and treatment of viral respiratory infection
WO2021255218A1 (en) 2020-06-19 2021-12-23 Charité - Universitätsmedizin Berlin A pharmaceutical combination comprising an anti-viral protonophore and a serine protease inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049859A1 (en) * 1998-03-28 1999-10-07 The Arizona Board Of Regents On Behalf Of The University Of Arizona Dfmo and sulindac combination in cancer chemoprevention
US6232312B1 (en) * 1995-06-07 2001-05-15 Cell Pathways, Inc. Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
US20030004143A1 (en) * 2001-04-18 2003-01-02 Prior Christopher P. Use of NSAIDs for prevention and treatment of cellular abnormalities of the female reproductive tract

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232312B1 (en) * 1995-06-07 2001-05-15 Cell Pathways, Inc. Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
WO1999049859A1 (en) * 1998-03-28 1999-10-07 The Arizona Board Of Regents On Behalf Of The University Of Arizona Dfmo and sulindac combination in cancer chemoprevention
US20030004143A1 (en) * 2001-04-18 2003-01-02 Prior Christopher P. Use of NSAIDs for prevention and treatment of cellular abnormalities of the female reproductive tract

Also Published As

Publication number Publication date
WO2011088474A2 (en) 2011-07-21

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