WO2011062864A3 - Inhibitors of nox enzymes and methods of use thereof - Google Patents

Inhibitors of nox enzymes and methods of use thereof Download PDF

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Publication number
WO2011062864A3
WO2011062864A3 PCT/US2010/056692 US2010056692W WO2011062864A3 WO 2011062864 A3 WO2011062864 A3 WO 2011062864A3 US 2010056692 W US2010056692 W US 2010056692W WO 2011062864 A3 WO2011062864 A3 WO 2011062864A3
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WO
WIPO (PCT)
Prior art keywords
inhibitors
methods
nox enzymes
nox
enzymes
Prior art date
Application number
PCT/US2010/056692
Other languages
French (fr)
Other versions
WO2011062864A2 (en
Inventor
John David Lambeth
Susan M. Smith
Tsukasa Kawahara
Jaeki Min
James Snyder
Aiming Sun
Thota Ganesh
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Publication of WO2011062864A2 publication Critical patent/WO2011062864A2/en
Publication of WO2011062864A3 publication Critical patent/WO2011062864A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D293/12—Selenazoles; Hydrogenated selenazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
    • C07D421/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings
    • C07D421/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D517/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D517/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains two hetero rings
    • C07D517/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Inhibitors of Nox enzymes, such as Noxl, Nox2, and Nox3, and methods of making and using such compounds are describe herein.
PCT/US2010/056692 2009-11-17 2010-11-15 Inhibitors of nox enzymes and methods of use thereof WO2011062864A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26180609P 2009-11-17 2009-11-17
US61/261,806 2009-11-17

Publications (2)

Publication Number Publication Date
WO2011062864A2 WO2011062864A2 (en) 2011-05-26
WO2011062864A3 true WO2011062864A3 (en) 2011-10-13

Family

ID=44060284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/056692 WO2011062864A2 (en) 2009-11-17 2010-11-15 Inhibitors of nox enzymes and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2011062864A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103172587B (en) * 2011-12-20 2017-08-08 天津市国际生物医药联合研究院有限公司 The amides compound of 3 ketone of benzisothiazole 2 with the inhibitory activity of Caspase 3
WO2014055634A1 (en) * 2012-10-02 2014-04-10 Yale University Identification of small molecule inhibitors of jumonji at-rich interactive domain 1a (jarid1a) and 1b (jarid1b) histone demethylase
CN103965188A (en) * 2013-01-29 2014-08-06 中山大学 Selenium-containing donepezil analogue
FR3020070B1 (en) * 2014-04-22 2018-11-02 Universite Grenoble Alpes PROTEINS NADPH OXIDASES
US9856253B2 (en) 2015-04-17 2018-01-02 Abbvie, Inc. Tricyclic modulators of TNF signaling
WO2016168638A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Indazolones as modulators of tnf signaling
UY36629A (en) 2015-04-17 2016-11-30 Abbvie Inc INDAZOLONAS AS MODULATORS OF THE TNF SIGNALING
CN105399656B (en) * 2015-12-21 2018-04-03 云南民族大学 A kind of iso-indoles alkaloid compound and preparation method and application
JOP20170113B1 (en) 2016-05-09 2023-03-28 Bayer Pharma AG Substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones and use thereof
CA3081775A1 (en) 2017-11-07 2019-05-16 Bayer Aktiengesellschaft Substituted 2,4-dihydro-3h-1,2,4-triazol-3-ones and use of same
JP2022547606A (en) * 2019-09-16 2022-11-14 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク Identification of compounds that inhibit TIA1-targeted stress granule formation and tau aggregation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007137255A2 (en) * 2006-05-22 2007-11-29 Thioredoxin Systems Ab Bacterial thioredoxin reductase inhibitors and methods for use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007137255A2 (en) * 2006-05-22 2007-11-29 Thioredoxin Systems Ab Bacterial thioredoxin reductase inhibitors and methods for use thereof
US20090005422A1 (en) * 2006-05-22 2009-01-01 Thioredoxin Systems Ab Bacterial thioredoxin reductase inhibitors and methods for use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOHN J. E. HADDAD ET AL.: "Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 296, no. 3, 2001, pages 996 - 1005 *
KYOKO WAKAMURA ET AL.: "Mechanism for the inhibitory effect of a seleno- organic compound, ebselen, and its analogs on superoxide anion production in guinea pig", JOURNAL OF PHARMACOBIO-DYNAMICS, vol. 13, no. 7, 1990, pages 421 - 425 *
RONG ZHAO ET AL.: "Ebselen: A substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 99, no. 13, 2002, pages 8579 - 8584 *

Also Published As

Publication number Publication date
WO2011062864A2 (en) 2011-05-26

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