WO2011031896A3 - Pi3 kinase inhibitors and uses thereof - Google Patents

Pi3 kinase inhibitors and uses thereof Download PDF

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Publication number
WO2011031896A3
WO2011031896A3 PCT/US2010/048317 US2010048317W WO2011031896A3 WO 2011031896 A3 WO2011031896 A3 WO 2011031896A3 US 2010048317 W US2010048317 W US 2010048317W WO 2011031896 A3 WO2011031896 A3 WO 2011031896A3
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WO
WIPO (PCT)
Prior art keywords
kinase inhibitors
compositions
methods
same
present
Prior art date
Application number
PCT/US2010/048317
Other languages
French (fr)
Other versions
WO2011031896A2 (en
Inventor
Deqiang Niu
Russell C. Petter
Juswinder Singh
Arthur F. Kluge
Hormoz Mazdiyasni
Zhendong Zhu
Lixin Qiao
Kevin Kuntz
Original Assignee
Avila Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SG2012016960A priority Critical patent/SG179085A1/en
Application filed by Avila Therapeutics, Inc. filed Critical Avila Therapeutics, Inc.
Priority to JP2012528906A priority patent/JP2013504325A/en
Priority to EP10816104A priority patent/EP2475375A4/en
Priority to RU2012110024/04A priority patent/RU2595718C2/en
Priority to CN201080048947XA priority patent/CN102625708A/en
Priority to NZ598808A priority patent/NZ598808A/en
Priority to BR112012008385A priority patent/BR112012008385A2/en
Priority to CA2773848A priority patent/CA2773848A1/en
Priority to MX2012002972A priority patent/MX339584B/en
Priority to AU2010292198A priority patent/AU2010292198A1/en
Publication of WO2011031896A2 publication Critical patent/WO2011031896A2/en
Publication of WO2011031896A3 publication Critical patent/WO2011031896A3/en
Priority to IL218555A priority patent/IL218555A0/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Abstract

The present invention provides compounds, compositions thereof, and methods of using the same.
PCT/US2010/048317 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof WO2011031896A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
NZ598808A NZ598808A (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof
JP2012528906A JP2013504325A (en) 2009-09-09 2010-09-09 PI3 kinase inhibitors and uses thereof
EP10816104A EP2475375A4 (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof
RU2012110024/04A RU2595718C2 (en) 2009-09-09 2010-09-09 Pi3-kinase inhibitors and use thereof
CN201080048947XA CN102625708A (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof
SG2012016960A SG179085A1 (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof
BR112012008385A BR112012008385A2 (en) 2009-09-09 2010-09-09 p13 kinase inhibitors and their use.
AU2010292198A AU2010292198A1 (en) 2009-09-09 2010-09-09 PI3 kinase inhibitors and uses thereof
MX2012002972A MX339584B (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof.
CA2773848A CA2773848A1 (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof
IL218555A IL218555A0 (en) 2009-09-09 2012-03-08 Pi3 kinase inhibitors and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24094709P 2009-09-09 2009-09-09
US61/240,947 2009-09-09
US37139610P 2010-08-06 2010-08-06
US61/371,396 2010-08-06

Publications (2)

Publication Number Publication Date
WO2011031896A2 WO2011031896A2 (en) 2011-03-17
WO2011031896A3 true WO2011031896A3 (en) 2011-05-12

Family

ID=43733099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/048317 WO2011031896A2 (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof

Country Status (15)

Country Link
US (1) US20110230476A1 (en)
EP (1) EP2475375A4 (en)
JP (1) JP2013504325A (en)
KR (1) KR20120063515A (en)
CN (1) CN102625708A (en)
AU (1) AU2010292198A1 (en)
BR (1) BR112012008385A2 (en)
CA (1) CA2773848A1 (en)
IL (1) IL218555A0 (en)
MX (1) MX339584B (en)
NZ (2) NZ626650A (en)
RU (1) RU2595718C2 (en)
SG (2) SG179085A1 (en)
TW (2) TWI499592B (en)
WO (1) WO2011031896A2 (en)

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US9556426B2 (en) 2009-09-16 2017-01-31 Celgene Avilomics Research, Inc. Protein kinase conjugates and inhibitors

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