WO2011055991A3 - A novel myxobacteria strain and a method for preparing epothilone using the same - Google Patents

A novel myxobacteria strain and a method for preparing epothilone using the same Download PDF

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Publication number
WO2011055991A3
WO2011055991A3 PCT/KR2010/007741 KR2010007741W WO2011055991A3 WO 2011055991 A3 WO2011055991 A3 WO 2011055991A3 KR 2010007741 W KR2010007741 W KR 2010007741W WO 2011055991 A3 WO2011055991 A3 WO 2011055991A3
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WO
WIPO (PCT)
Prior art keywords
strain
myxobacteria
novel
same
epothilone
Prior art date
Application number
PCT/KR2010/007741
Other languages
French (fr)
Other versions
WO2011055991A2 (en
Inventor
Bu Soo Park
Chong Jin Park
Mee Jeong Lee
Yong Soon Hwang
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Samyang Genex Corporation
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Publication date
Application filed by Samyang Genex Corporation filed Critical Samyang Genex Corporation
Publication of WO2011055991A2 publication Critical patent/WO2011055991A2/en
Publication of WO2011055991A3 publication Critical patent/WO2011055991A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Sorangium cellulosum SYC248 strain capable of producing a high concentration of epothilone with antibiotic/anticancer activities isolated from Korean soil and having a high growth rate, and a method for preparing epothilone using the strains are provided.
PCT/KR2010/007741 2009-11-05 2010-11-04 A novel myxobacteria strain and a method for preparing epothilone using the same WO2011055991A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0106267 2009-11-05
KR1020090106267A KR20110049304A (en) 2009-11-05 2009-11-05 A novel myxobacteria strain and a method for preparing epothilone using the same

Publications (2)

Publication Number Publication Date
WO2011055991A2 WO2011055991A2 (en) 2011-05-12
WO2011055991A3 true WO2011055991A3 (en) 2011-11-03

Family

ID=43970552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/007741 WO2011055991A2 (en) 2009-11-05 2010-11-04 A novel myxobacteria strain and a method for preparing epothilone using the same

Country Status (2)

Country Link
KR (1) KR20110049304A (en)
WO (1) WO2011055991A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101372563B1 (en) * 2011-12-26 2014-03-14 주식회사 삼양바이오팜 Method of isolating and purifying epothilone A and B from epothilone containing material
CN103146594B (en) * 2012-11-08 2015-04-01 山东轻工业学院 Sorangiumcellulosum strain and application thereof to synthesis of epothilone
CN103145722B (en) * 2013-03-05 2015-12-02 福建省微生物研究所 A kind of method of high speed adverse current chromatogram separating-purifying ebormycine
CN103937851A (en) * 2014-04-23 2014-07-23 陕西科技大学 Method for producing epothilone B based on coupling of microbial fermentation and membrane separation techniques
CN103937852A (en) * 2014-04-23 2014-07-23 陕西科技大学 Method for preparing epothilone B based on coupling of separation and fermentation of molecularly imprinted membrane
CN109306348A (en) * 2018-11-05 2019-02-05 湖南迪诺制药股份有限公司 A kind of Epothilones superior strain selection and bacterial strain

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GERTH, K. ET AL.: "Epothilons A and B: antifungal and cytotoxic compounds fro m Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biol ogical properties", JOURNAL OF ANTIBIOTICS, vol. 49, no. 6, June 1996 (1996-06-01), TOKYO, pages 560 - 563 *
GONG, G. L. ET AL.: "Mutation and a high-throughput screening method for impr oving the production of Epothilones of Soragium", JOURNAL OF INDUSTRIAL MICROBIOLOGY AND BIOTECHNOLOGY., vol. 34, no. 9, 24 July 2007 (2007-07-24), pages 615 - 623 *
HARDT, . H. ET AL.: "New natural epothilones from Sorangium cellulosum, stra ins So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR stu dies", JOURNAL OF NATURAL PRODUCTS, vol. 64, no. 7, July 2001 (2001-07-01), pages 847 - 856 *
HYUN, H. ET AL.: "Isolation of Sorangium cellulosum carrying epothilone gene clusters", JOURNAL OF MICROBIOLOGY AND BIOTECLINOLOGY., vol. 18, no. 8, August 2008 (2008-08-01), pages 1416 - 1422 *

Also Published As

Publication number Publication date
WO2011055991A2 (en) 2011-05-12
KR20110049304A (en) 2011-05-12

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