WO2011034341A3 - 저분자량 히알루론산 제조 방법 - Google Patents

저분자량 히알루론산 제조 방법 Download PDF

Info

Publication number
WO2011034341A3
WO2011034341A3 PCT/KR2010/006312 KR2010006312W WO2011034341A3 WO 2011034341 A3 WO2011034341 A3 WO 2011034341A3 KR 2010006312 W KR2010006312 W KR 2010006312W WO 2011034341 A3 WO2011034341 A3 WO 2011034341A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecular weight
hyaluronic acid
weight hyaluronic
low molecular
present
Prior art date
Application number
PCT/KR2010/006312
Other languages
English (en)
French (fr)
Other versions
WO2011034341A2 (ko
Inventor
강대중
임종혁
강재훈
Original Assignee
일동제약주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43759170&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2011034341(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 일동제약주식회사 filed Critical 일동제약주식회사
Priority to ES10817410T priority Critical patent/ES2535625T5/es
Priority to EP10817410.3A priority patent/EP2479194B2/en
Priority to CN201080041200.1A priority patent/CN102630231B/zh
Priority to JP2012529671A priority patent/JP5750442B2/ja
Priority to BR112012005816-9A priority patent/BR112012005816B1/pt
Publication of WO2011034341A2 publication Critical patent/WO2011034341A2/ko
Publication of WO2011034341A3 publication Critical patent/WO2011034341A3/ko
Priority to US13/419,004 priority patent/US20120232261A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003General processes for their isolation or fractionation, e.g. purification or extraction from biomass

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Sustainable Development (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 스트렙토코크스 속 ID9102에 의해 생산된 고분자 히알루론산을 저분자 히알루론산으로 만드는 방법에 관한 것이다. 구체적으로, 본발명은 고분자 히알루론산과 활성탄을 일정 분해 조건 하에서 반응시켜 히알루론산 고유의 특성은 유지하고 히알루론산 분자량은 일정하게 줄이는 방법에 관한 것이다. 본 발명에 따른 고분자 히알루론산의 저분자화 방법은 ph 처리의 조건이나 각 종 반응 촉매 그리고 가열 등의 복잡한 추가 처리 조건을 필요로 하는 공지의 방법에 비하여 공정이 편리하고 투입된 재료의 제거를 위한 재처리의 불편함이 없으며 동시에 오히려 불순물을 제거하는 효과까지 동반하는 것이기 때문에 간편하고 경제적이며 고순도로 저분자 히알루론산을 생산할 수 있다. 본 발명에 따른 저분자화 방법은 활성탄을 이용한 반응 조건의 변경에 따라 저분자 히알루론산의 분자량을 다양하게 조절할 수 있는 장점이 있다. 본발명에 따라 생산되는 저분자 히알루론산은 히알루론산 고유의 특성은 유지한 채 의약품 규격에 적합하게 제조될 수 있으며, 또한 화장품이나 식품용으로 사용되는 규격으로 적합하게 제조 될 수 있다.
PCT/KR2010/006312 2009-09-15 2010-09-15 저분자량 히알루론산 제조 방법 WO2011034341A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES10817410T ES2535625T5 (es) 2009-09-15 2010-09-15 Método para fabricar ácido hialurónico de bajo peso molecular
EP10817410.3A EP2479194B2 (en) 2009-09-15 2010-09-15 Method for manufacturing low molecular weight hyaluronic acid
CN201080041200.1A CN102630231B (zh) 2009-09-15 2010-09-15 低分子量透明质酸的制造方法
JP2012529671A JP5750442B2 (ja) 2009-09-15 2010-09-15 低分子量ヒアルロン酸製造方法
BR112012005816-9A BR112012005816B1 (pt) 2009-09-15 2010-09-15 método para a fabricação de ácido hialurônico de baixo peso molecular
US13/419,004 US20120232261A1 (en) 2009-09-15 2012-03-13 Method for manufacturing low molecular weight hyaluronic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0087185 2009-09-15
KR1020090087185A KR101132114B1 (ko) 2009-09-15 2009-09-15 히알루론산의 분자량을 조절하는 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/419,004 Continuation US20120232261A1 (en) 2009-09-15 2012-03-13 Method for manufacturing low molecular weight hyaluronic acid

Publications (2)

Publication Number Publication Date
WO2011034341A2 WO2011034341A2 (ko) 2011-03-24
WO2011034341A3 true WO2011034341A3 (ko) 2011-07-14

Family

ID=43759170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/006312 WO2011034341A2 (ko) 2009-09-15 2010-09-15 저분자량 히알루론산 제조 방법

Country Status (8)

Country Link
US (1) US20120232261A1 (ko)
EP (1) EP2479194B2 (ko)
JP (1) JP5750442B2 (ko)
KR (1) KR101132114B1 (ko)
CN (1) CN102630231B (ko)
BR (1) BR112012005816B1 (ko)
ES (1) ES2535625T5 (ko)
WO (1) WO2011034341A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101322227B1 (ko) 2011-09-30 2013-10-28 일동제약주식회사 스트렙토코커스 디스갈락티애 id9103 균주 및 이를 이용한 히알루론산 생산 방법
KR101598329B1 (ko) * 2013-03-20 2016-02-29 일동제약주식회사 히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물
EP2910255A1 (en) 2014-02-19 2015-08-26 MedSkin Solutions Dr. Suwelack AG Methods for the production of biopolymers with defined average molecular weight
CN105777937A (zh) * 2016-03-22 2016-07-20 山东众山生物科技有限公司 一种从透明质酸发酵液中制备透明质酸钠的方法
KR102240239B1 (ko) 2019-04-23 2021-04-14 (주)티엠비 저분자량 히알루론산의 제조방법 및 이로부터 제조된 저분자량 히알루론산
CN111040048A (zh) * 2019-12-21 2020-04-21 南京汉欣医药科技有限公司 一种超低分子量透明质酸及其制备方法
KR102451308B1 (ko) 2022-02-21 2022-10-07 이광미 금속 티오옥토일 히알루로네이트 복합체 및 이의 제조 방법

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278593A (en) * 1979-01-11 1981-07-14 Nobuhiko Katsunuma Glucocorticoid sparing factor and process for the production of the same
US5756721A (en) * 1991-01-16 1998-05-26 National Starch And Chemical Investment Holding Corporation Purification of polysaccharides
JPH10195107A (ja) * 1997-01-10 1998-07-28 Shiseido Co Ltd オリゴ硫酸化ヒアルロン酸
JP3113056B2 (ja) * 1992-03-13 2000-11-27 鐘紡株式会社 養毛料
JP2002360292A (ja) * 2001-06-11 2002-12-17 Medicaraise Corp 低分子ヒアルロン酸の抽出方法及び低分子ヒアルロン酸を含有する食品
KR20080046821A (ko) * 2006-11-23 2008-05-28 주식회사 엘지생명과학 히알루론산의 정제방법

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4758642A (en) * 1985-12-11 1988-07-19 Exxon Chemical Patents Inc. Process for preparing improved high solids acrylic-based coatings
JPS6357602A (ja) 1986-08-29 1988-03-12 Q P Corp 低分子ヒアルロン酸の製法
JP2549119B2 (ja) * 1987-05-30 1996-10-30 三省製薬株式会社 外用剤
FR2617510B1 (fr) * 1987-07-01 1991-06-07 Snecma Procede de codeposition electrolytique d'une matrice nickel-cobalt et de particules ceramiques et revetement obtenu
JP2587268B2 (ja) 1988-04-18 1997-03-05 チッソ株式会社 低粘度ヒアルロン酸又はその塩の製造方法
JPH0222301A (ja) 1988-07-12 1990-01-25 Nippon Kayaku Co Ltd 水溶性キトサンの製造方法
JPH0675512B2 (ja) 1989-03-20 1994-09-28 株式会社紀文食品 低重合度ヒアルロン酸アルカリ塩の製造方法
JPH0630605B2 (ja) * 1990-10-23 1994-04-27 チッソ株式会社 ヒアルロン酸ナトリウム水溶液の製造法
JP4151092B2 (ja) * 1997-10-22 2008-09-17 チッソ株式会社 オリゴヒアルロン酸もしくはその塩の製造法
JP4587148B2 (ja) * 2000-03-24 2010-11-24 生化学工業株式会社 平滑筋細胞増殖促進剤
KR100369517B1 (ko) 2000-08-29 2003-01-29 김공수 저분자 다당류 및 그들의 올리고당 제조방법
US7575914B2 (en) * 2002-08-19 2009-08-18 Kolon Life Science, Inc. Microorganism producing hyaluronic acid and purification method of hyaluronic acid
CN1563109A (zh) * 2004-04-13 2005-01-12 阮春学 一种制备透明质酸的方法
JP4528898B2 (ja) * 2004-07-26 2010-08-25 独立行政法人科学技術振興機構 ケモカイン受容体ccr10の発現誘導剤
JP4576583B2 (ja) * 2005-03-22 2010-11-10 キユーピー株式会社 ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
CN101020724A (zh) * 2006-02-14 2007-08-22 镇江东方生物工程设备技术有限责任公司 一种低分子量透明质酸钠的制备方法
JPWO2007142285A1 (ja) * 2006-06-07 2009-10-29 協和発酵バイオ株式会社 ヒアルロン酸塩の精製方法
CN101244383A (zh) * 2008-03-13 2008-08-20 同济大学 一种活性炭负载二氧化钛光催化剂的制备方法
CN101293934A (zh) * 2008-05-26 2008-10-29 江南大学 一种用过氧化氢和抗坏血酸氧化降解法生产小分子量透明质酸的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278593A (en) * 1979-01-11 1981-07-14 Nobuhiko Katsunuma Glucocorticoid sparing factor and process for the production of the same
US5756721A (en) * 1991-01-16 1998-05-26 National Starch And Chemical Investment Holding Corporation Purification of polysaccharides
JP3113056B2 (ja) * 1992-03-13 2000-11-27 鐘紡株式会社 養毛料
JPH10195107A (ja) * 1997-01-10 1998-07-28 Shiseido Co Ltd オリゴ硫酸化ヒアルロン酸
JP2002360292A (ja) * 2001-06-11 2002-12-17 Medicaraise Corp 低分子ヒアルロン酸の抽出方法及び低分子ヒアルロン酸を含有する食品
KR20080046821A (ko) * 2006-11-23 2008-05-28 주식회사 엘지생명과학 히알루론산의 정제방법

Also Published As

Publication number Publication date
KR20110029492A (ko) 2011-03-23
JP2013504679A (ja) 2013-02-07
JP5750442B2 (ja) 2015-07-22
BR112012005816A2 (pt) 2020-08-25
US20120232261A1 (en) 2012-09-13
EP2479194A4 (en) 2013-09-11
WO2011034341A2 (ko) 2011-03-24
EP2479194A2 (en) 2012-07-25
EP2479194B1 (en) 2015-01-28
CN102630231A (zh) 2012-08-08
EP2479194B2 (en) 2018-08-01
ES2535625T3 (es) 2015-05-13
BR112012005816B1 (pt) 2021-03-09
KR101132114B1 (ko) 2012-04-05
CN102630231B (zh) 2015-05-27
ES2535625T5 (es) 2019-01-10

Similar Documents

Publication Publication Date Title
WO2011034341A3 (ko) 저분자량 히알루론산 제조 방법
NZ602359A (en) Processing biomass
MX2011007912A (es) Leche y productos relacionados con la leche con vida de anaquel prolongada y un proceso y una planta de procesamiento de leche para su manufactura.
WO2011003034A3 (en) Biological methods for preparing adipic acid
EP2307477A4 (en) NOVEL COORDINATION COMPLEXES AND PROCESS USING SUCH COMPLEX AS CATALYST TO PRODUCE POLYCARBONATE BY COPOLYMERIZATION OF CARBON DIOXIDE AND EPOXY
WO2010014976A3 (en) Microbial treatment of lignocellulosic biomass
WO2009128973A3 (en) Methods for the production of silver nanowires
WO2011047372A3 (en) Integration of anaerobic digestion in an algae-based biofuel system
PH12015502111A1 (en) Stabilized chlorine dioxide to preserve carbohydrate feedstocks
WO2010115201A3 (en) Reactor system and method for processing a process fluid
WO2009014138A1 (ja) 精製含フッ素ポリマーの製造方法
WO2013104911A3 (en) Anaerobic process
WO2008143047A1 (ja) 樹状細胞の製造方法
MX350347B (es) Procedimiento para la produccion de un catalizador de zeolita activo para una scr, asi como un catalizador de zeolita activo para una scr.
WO2014095669A3 (de) Verfahren und anlage zur herstellung von biogas aus lignocellulosehaltiger biomasse
AU2012268669A8 (en) Process for the production of chlorinated and/or fluorinated propenes
WO2008102519A1 (ja) 酢酸菌のクオラムセンシングシステムに関与する遺伝子、該遺伝子を修飾して育種された酢酸菌、及び該酢酸菌を用いた食酢の製造方法
CN103088201A (zh) 一种风机叶轮材质的时效处理方法
WO2010037699A3 (de) Verfahren zur pyrolyse von kohlehydraten
WO2011044496A3 (en) LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS
JO3135B1 (ar) طريقة لانتاج حمض الهيدروكلوريك لانتاج حمض الفسفوريك من الغذاء
WO2020122836A3 (en) Method for nitrogen-doped graphene production
WO2010064262A3 (en) A process for production of water soluble melanin using a strain of the fungus gliocephalotrichum
MX2015001413A (es) Metodo de alta eficiencia para purificar particulas similares a virus del virus del papiloma humano.
WO2011123508A4 (en) Methods for producing pyrolysis products

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080041200.1

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10817410

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2012529671

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2010817410

Country of ref document: EP

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112012005816

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112012005816

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20120315