WO2011028483A3 - Methods and apparatus for segregation of particles, including additional sources of sample collection for separation of nucleated fetal cells - Google Patents

Methods and apparatus for segregation of particles, including additional sources of sample collection for separation of nucleated fetal cells Download PDF

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Publication number
WO2011028483A3
WO2011028483A3 PCT/US2010/046350 US2010046350W WO2011028483A3 WO 2011028483 A3 WO2011028483 A3 WO 2011028483A3 US 2010046350 W US2010046350 W US 2010046350W WO 2011028483 A3 WO2011028483 A3 WO 2011028483A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
segregation
separation
methods
sample collection
Prior art date
Application number
PCT/US2010/046350
Other languages
French (fr)
Other versions
WO2011028483A2 (en
Inventor
George Hvichia
David Counts
Gary Evans
Original Assignee
Parsortix, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parsortix, Inc. filed Critical Parsortix, Inc.
Priority to US12/910,299 priority Critical patent/US20110065181A1/en
Publication of WO2011028483A2 publication Critical patent/WO2011028483A2/en
Publication of WO2011028483A3 publication Critical patent/WO2011028483A3/en
Priority to US15/586,981 priority patent/US20170234851A1/en
Priority to US15/870,381 priority patent/US20180299425A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5002—Partitioning blood components

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are accommodated in a passage bounded by a first step, but at least some of the particles are unable to pass through a narrower passage bounded by a second step, resulting in segregation of the particles. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate fetal-like cells from a maternal blood sample such as maternal arterial blood.
PCT/US2010/046350 2008-04-23 2010-08-23 Methods and apparatus for segregation of particles, including additional sources of sample collection for separation of nucleated fetal cells WO2011028483A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/910,299 US20110065181A1 (en) 2008-04-23 2010-10-22 Methods and Apparatus for Segregation of Particles
US15/586,981 US20170234851A1 (en) 2008-04-23 2017-05-04 Methods and Apparatus for Segregation of Particles
US15/870,381 US20180299425A1 (en) 2008-04-23 2018-01-12 Methods and Apparatus for Segregation of Particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23620509P 2009-08-24 2009-08-24
US61/236,205 2009-08-24

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2009/002421 Continuation-In-Part WO2009131645A2 (en) 2008-04-23 2009-04-17 Methods and apparatus for segregation of particles
US12/910,299 Continuation-In-Part US20110065181A1 (en) 2008-04-23 2010-10-22 Methods and Apparatus for Segregation of Particles
AU2010246381A Division AU2010246381B2 (en) 2008-04-23 2010-11-23 Methods and apparatus for segregation of particles

Publications (2)

Publication Number Publication Date
WO2011028483A2 WO2011028483A2 (en) 2011-03-10
WO2011028483A3 true WO2011028483A3 (en) 2011-06-23

Family

ID=43649881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/046350 WO2011028483A2 (en) 2008-04-23 2010-08-23 Methods and apparatus for segregation of particles, including additional sources of sample collection for separation of nucleated fetal cells

Country Status (1)

Country Link
WO (1) WO2011028483A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9631179B2 (en) 2013-03-15 2017-04-25 Angle North America, Inc. Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge
CN110595971A (en) * 2019-10-16 2019-12-20 恒天益科技（深圳）有限公司 Ultra-low dust meter

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10332603A (en) * 1997-05-30 1998-12-18 Omron Corp Method and equipment for inspecting microgap
JP2003180336A (en) * 2000-12-07 2003-07-02 Effector Cell Institute Inc Detection of cell chemotaxis and well unit for chemotactic cell separator
JP2007267635A (en) * 2006-03-30 2007-10-18 Kitakyushu Foundation For The Advancement Of Industry Science & Technology Cell separation tool and method for separating cell by using the same
KR20070116585A (en) * 2005-01-18 2007-12-10 바이오셉트 인코포레이티드 Cell separation using microchannel having patterned posts
KR100788458B1 (en) * 2006-09-08 2007-12-24 한국과학기술원 Microfluidic chip for cell separation based on hydrophoresis and its separation method of blood cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10332603A (en) * 1997-05-30 1998-12-18 Omron Corp Method and equipment for inspecting microgap
JP2003180336A (en) * 2000-12-07 2003-07-02 Effector Cell Institute Inc Detection of cell chemotaxis and well unit for chemotactic cell separator
KR20070116585A (en) * 2005-01-18 2007-12-10 바이오셉트 인코포레이티드 Cell separation using microchannel having patterned posts
JP2007267635A (en) * 2006-03-30 2007-10-18 Kitakyushu Foundation For The Advancement Of Industry Science & Technology Cell separation tool and method for separating cell by using the same
KR100788458B1 (en) * 2006-09-08 2007-12-24 한국과학기술원 Microfluidic chip for cell separation based on hydrophoresis and its separation method of blood cells

Also Published As

Publication number Publication date
WO2011028483A2 (en) 2011-03-10

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