WO2011015920A3 - A highly efficient process of purification and production of recombinant trastuzumab - Google Patents

A highly efficient process of purification and production of recombinant trastuzumab Download PDF

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Publication number
WO2011015920A3
WO2011015920A3 PCT/IB2010/001897 IB2010001897W WO2011015920A3 WO 2011015920 A3 WO2011015920 A3 WO 2011015920A3 IB 2010001897 W IB2010001897 W IB 2010001897W WO 2011015920 A3 WO2011015920 A3 WO 2011015920A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
recombinant
purification
highly efficient
recovery
Prior art date
Application number
PCT/IB2010/001897
Other languages
French (fr)
Other versions
WO2011015920A2 (en
Inventor
Villoo Morawala Patell
Sami N. Guzder
Sunit Maity
Sunil Shekar
Chitta Geetha
Babu Nabi
Srinivasan Ragunath
Original Assignee
Avesthagen Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avesthagen Limited filed Critical Avesthagen Limited
Publication of WO2011015920A2 publication Critical patent/WO2011015920A2/en
Publication of WO2011015920A3 publication Critical patent/WO2011015920A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Abstract

The present invention relates to use of novel process of production and recovery of recombinant Monoclonal antibody to HER-2, in biologically active form from fluids, includes but not limited to mammalian host cell culture supernatants by performing fermentation and chromatographic procedure separately and jointly. The recovery by the novel process can be very useful in pharmaceutical industries as it as it furnishes the rapid and efficient recovery of Recombinant Trastuzumab.
PCT/IB2010/001897 2009-08-03 2010-08-02 A highly efficient process of purification and production of recombinant trastuzumab WO2011015920A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1841CH2009 2009-08-03
IN1841/CHE/2009 2009-08-03

Publications (2)

Publication Number Publication Date
WO2011015920A2 WO2011015920A2 (en) 2011-02-10
WO2011015920A3 true WO2011015920A3 (en) 2011-05-12

Family

ID=43544727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/001897 WO2011015920A2 (en) 2009-08-03 2010-08-02 A highly efficient process of purification and production of recombinant trastuzumab

Country Status (1)

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WO (1) WO2011015920A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013189544A1 (en) * 2012-06-21 2013-12-27 Synthon B.V. Method of purifying an antibody
US20140017265A1 (en) * 2012-07-05 2014-01-16 Mersana Therapeutics, Inc. Terminally Modified Polymers and Conjugates Thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016968A2 (en) * 2003-07-28 2005-02-24 Genentech, Inc. Reducing protein a leaching during protein a affinity chromatography
WO2005081711A2 (en) * 2003-11-06 2005-09-09 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
WO2009108637A1 (en) * 2008-02-25 2009-09-03 Prometheus Laboratories, Inc. Drug selection for breast cancer therapy using antibody-based arrays

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016968A2 (en) * 2003-07-28 2005-02-24 Genentech, Inc. Reducing protein a leaching during protein a affinity chromatography
WO2005081711A2 (en) * 2003-11-06 2005-09-09 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
WO2009108637A1 (en) * 2008-02-25 2009-09-03 Prometheus Laboratories, Inc. Drug selection for breast cancer therapy using antibody-based arrays

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PAUL CARTER ET AL.: "Humanization of an anti-p185HER2 antibody for human cancer therapy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE OF THE USA, vol. 89, pages 4285 - 4289, XP055124497 *

Also Published As

Publication number Publication date
WO2011015920A2 (en) 2011-02-10

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