WO2010143803A3 - New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same - Google Patents
New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same Download PDFInfo
- Publication number
- WO2010143803A3 WO2010143803A3 PCT/KR2010/000960 KR2010000960W WO2010143803A3 WO 2010143803 A3 WO2010143803 A3 WO 2010143803A3 KR 2010000960 W KR2010000960 W KR 2010000960W WO 2010143803 A3 WO2010143803 A3 WO 2010143803A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- same
- antiandrogens
- nicotinamide derivatives
- androgen
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided are novel nicotinamide derivatives and pharmaceutically acceptable salts thereof with anti-androgen effects, preparing processes of the same and antiandrogens containing the same as active ingredients. More particularly, the said nicotinamide derivatives have anti-androgen activity, so that they can be effectively used as a preventive or therapeutic agent for androgen-related diseases such as prostatic disease, androgenic alopecia and acne.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20090050320 | 2009-06-08 | ||
KR10-2009-0050320 | 2009-06-08 | ||
KR1020090069557A KR101103503B1 (en) | 2009-06-08 | 2009-07-29 | New nicotinamide derivatives with anti-androgen effect, process for preparing and anti-androgens comprising the same |
KR10-2009-0069557 | 2009-07-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010143803A2 WO2010143803A2 (en) | 2010-12-16 |
WO2010143803A3 true WO2010143803A3 (en) | 2011-01-27 |
Family
ID=43309310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2010/000960 WO2010143803A2 (en) | 2009-06-08 | 2010-02-17 | New nicotinamide derivatives with anti-androgen effects, processes of preparing, and antiandrogens comprising the same |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2010143803A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2982261B1 (en) | 2011-11-04 | 2014-06-13 | Galderma Res & Dev | NOVEL AMIDES, AND THEIR PHARMACEUTICAL OR COSMETIC USE |
US9682960B2 (en) | 2013-12-19 | 2017-06-20 | Endorecherche, Inc. | Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety |
WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030050325A1 (en) * | 1997-09-05 | 2003-03-13 | Bruno Bernard | Novel compounds of the indolecarboxylic family and use thereof |
WO2003082853A1 (en) * | 2002-03-28 | 2003-10-09 | Astrazeneca Ab | New compounds |
US20060025426A1 (en) * | 2002-12-11 | 2006-02-02 | Fraley Mark E | Tyrosine kinase inhibitors |
US20060111355A1 (en) * | 2004-11-23 | 2006-05-25 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
WO2007061880A1 (en) * | 2005-11-23 | 2007-05-31 | Merck & Co., Inc. | Spirocyclic compounds as hdac inhibitors |
US20080221157A1 (en) * | 2004-07-12 | 2008-09-11 | Istituto Di Ricerche Di Biologia Molecolare P Ange | Amide Derivatives as Inhibitors of Histone Deacetylase |
US20090105264A1 (en) * | 2005-11-03 | 2009-04-23 | Christopher Hamblett | Substituted Nicotinamide Compounds |
-
2010
- 2010-02-17 WO PCT/KR2010/000960 patent/WO2010143803A2/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030050325A1 (en) * | 1997-09-05 | 2003-03-13 | Bruno Bernard | Novel compounds of the indolecarboxylic family and use thereof |
WO2003082853A1 (en) * | 2002-03-28 | 2003-10-09 | Astrazeneca Ab | New compounds |
US20060025426A1 (en) * | 2002-12-11 | 2006-02-02 | Fraley Mark E | Tyrosine kinase inhibitors |
US20080221157A1 (en) * | 2004-07-12 | 2008-09-11 | Istituto Di Ricerche Di Biologia Molecolare P Ange | Amide Derivatives as Inhibitors of Histone Deacetylase |
US20060111355A1 (en) * | 2004-11-23 | 2006-05-25 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
US20090105264A1 (en) * | 2005-11-03 | 2009-04-23 | Christopher Hamblett | Substituted Nicotinamide Compounds |
WO2007061880A1 (en) * | 2005-11-23 | 2007-05-31 | Merck & Co., Inc. | Spirocyclic compounds as hdac inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2010143803A2 (en) | 2010-12-16 |
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