WO2010133997A1 - Dispositif de diagnostique à détecteur d'application d'échantillon - Google Patents

Dispositif de diagnostique à détecteur d'application d'échantillon Download PDF

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Publication number
WO2010133997A1
WO2010133997A1 PCT/IB2010/052015 IB2010052015W WO2010133997A1 WO 2010133997 A1 WO2010133997 A1 WO 2010133997A1 IB 2010052015 W IB2010052015 W IB 2010052015W WO 2010133997 A1 WO2010133997 A1 WO 2010133997A1
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WO
WIPO (PCT)
Prior art keywords
cartridge
sample
reaction chamber
assay
sensing
Prior art date
Application number
PCT/IB2010/052015
Other languages
English (en)
Inventor
Albert H. J. Immink
Jeroen H. Nieuwenhuis
Joost H. Maas
Original Assignee
Koninklijke Philips Electronics N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics N. V. filed Critical Koninklijke Philips Electronics N. V.
Publication of WO2010133997A1 publication Critical patent/WO2010133997A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings

Definitions

  • the present invention relates to cartridges for diagnostic devices with sensors to detect the presence of a sample liquid.
  • the present invention further relates to methods to perform diagnostic assays wherein the presence of a sample liquid at different portions in a cartridge is measured and decisions are made to continue or discontinue an assay.
  • Diagnostic devices for drug of abuse testing in saliva or for medical diagnostics in blood samples are more and more used in point-of-care situations where the test is performed directly at the roadside, the bedside, at the physician's office or even at home.
  • samples such as blood
  • the simplest way to obtain blood is by a finger-prick. Typically, 20 ⁇ l can be conveniently withdrawn from the finger.
  • cartridges are being developed that have a dead volume that is as low as possible.
  • Such a cartridge typically fills automatically without any further operator intervention, by capillary filling of a channel between the application region and the reaction chamber and the reaction chamber itself, after the blood has been applied to the application zone of a cartridge.
  • the operator of a device can not easily assess by visual observation if the volume of applied sample was large enough to fill the complete cartridge. Performing an assay and relying on the assay results when the reaction chamber is not or incompletely filled may have legal (especially in drug of abuse testing) or medical consequences.
  • One aspect of the invention relates to a cartridge (1) for a diagnostic device (11) comprising a sample fluid application region (2), a reaction chamber (4) and a channel (3) connecting the application chamber to the reaction chamber.
  • the channel (3) comprises a proximal (31) and a distal part (32).
  • the reaction chamber comprises a sensing zone (5) at the exit of the reaction chamber for detection the filling of the reaction chamber with sample fluid.
  • the sample application region (2) or the proximal part of the channel (31) comprises a sensing zone (7) for sensing the application of the sample fluid on the cartridge.
  • such cartridges comprise a sensing zone (6) for sensing the sample fluid at the entry of the reaction chamber.
  • the sensing zone is an electrode or a transparent region for optical detection.
  • the sample application zone comprises a filter (8) for retaining cells from a blood sample.
  • the sensing zone (6) is in contact with the filter (8).
  • Another aspect of the invention relates to a device (11) for performing a diagnostic assay, comprising a cartridge as described above, wherein the device comprising detection units (51) and (71) and optionally detection units (61) for detecting the presence of a liquid on the sensing zones.
  • these devices further comprise a data processing unit (10) for measuring the time between the application of the sample fluid and the filling of the device.
  • Such a detection unit can be photospectrometer.
  • the detection unit measures frustrated total internal reflection (FTIR) or measures changes in conductivity.
  • FTIR frustrated total internal reflection
  • control elements (91) are present which interact with a data processing unit (10) for starting or stopping an assay.
  • Another aspect of the present invention relates to a method for performing an assay in a cartridge according to claim 1, inserted in a diagnostic device (11). This method comprising the steps of:
  • the cartridge comprises a sample fluid application region (2), a reaction chamber (4) and a channel (3) connecting the application chamber to the reaction chamber, the cartridge comprising one or sensing zones for detecting the presence of sample fluid within the cartridge.
  • the device comprises a detection unit for detecting the presence of a liquid on the one or more sensing zones, and the device comprises a sensor for detection the presence of the cartridge in the device.
  • a further aspect of the present invention relates to a method for quality control of a diagnostic assay.
  • the method comprising the steps of:
  • a cartridge (1) for a diagnostic device (11) comprising a sample fluid application region (2), a reaction chamber (4) and a channel (3) connecting the application chamber to the reaction chamber, the cartridge comprising one or more sensing zones (5, 6, 7) for detecting the presence of sample fluid within the cartridge, - inserting the cartridge into the device,
  • the sensing zone is positioned at the exit of the reaction chamber.
  • the sensing zones and their arrangement as described in the present invention allow problems with sample application, sample transport, and filling of a reaction chamber to be identified.
  • the system will not detect wetting and the assay/actuation procedure will not start.
  • a similar problem occurs when the cartridge is damaged, the sample is too viscous, or contains particulate matter that blocks or retards the fluid flow. In such conditions the operator (and more important the patient) will keep waiting but will not get an assay result.
  • the design and use of cartridges make it possible to perform an assay without running an external timer, or to push a button after sample application, because the moment of sample application is known to the system. This makes the described methods very convenient and less prone to errors.
  • Fig 1 shows a schematic overview of a cartridge (1) inserted into a diagnostic device (11) in accordance with an embodiment of the invention.
  • Fig. 2 shows examples of configurations of sample application zones (2) with sensing zone (7).
  • Fig. 3 shows a schematic overview of a cartridge (1) inserted into a diagnostic device (11) in accordance with an embodiment of the invention, wherein the device further comprises a sensor (12) for detecting the insertion of the cartridge into the device.
  • the same reference signs refer to the same or analogous elements.
  • Sensor as used herein relates to a means for detecting the presence of an aqueous liquid.
  • a sensor comprises a sensing zone in a cartridge, which is connected to a detection unit in a diagnostic device upon insertion of the cartridge in the device.
  • proximal as used herein describes the part of a structural element (channel, reaction chamber) adjacent to the sample inlet.
  • distal as used herein describes the part of a structural element (channel, reaction chamber) adjacent to the entrance to the reaction chamber and remote from the sample so that the distal part is located further down the sample stream direction from the sample inlet than the proximal part.
  • Cartridges as described herein are housings comprising a sample application region which is separated from a reaction chamber by a channel.
  • Fig. 1 shows a schematic overview of a cartridge (1) inserted into a diagnostic device (11) in accordance with an embodiment of the invention, wherein the cartridge comprises a sample application region (2), connected via a channel (3), with a proximal (31) and distal side (32), to reaction chamber (4).
  • the cartridge contains sensing zones (5, 6 and 7) connected via a detection unit (51, 61, and 71) to a data processing unit (10).
  • a filter (8) is depicted within the sample application region. Means for performing an assay (9) and control elements (91) for performing, detecting and processing assay results are indicated.
  • This configuration allows inserting a cartridge in a device such that the sample application region, which may have been contaminated by contact with fingers or mouth, remains outside the device when this is inserted in the device.
  • the cartridge will become already (partially) filled with sample liquid before the insertion into the device.
  • the presence of sample liquid at one or more of the sensing zones will be monitored.
  • the configuration also encompasses inserting the appropriate cartridge in a device, where after a sample is applied on the sample application region of the cartridge.
  • Methods and cartridges as describes in embodiments of the present invention are particularly suitable when a cartridge is inserted in a device prior to the application of a sample on the inserted cartridge.
  • the sample application region which is connected to the channel, may differ in size, shape and material depending on the type of sample or the design of the cartridge.
  • a sample application region is a depression in the cartridge defining a small volume.
  • Alternative sample application regions are made of fabrics (paper, cellulose, etc.) which stick out of a cartridge and which provide a wick connecting the exterior of the cartridge to the channel.
  • the sample application region can have the form of an internal space within the cartridge which is filled by a syringe or a sponge, where after the sample liquid further migrates from this space to the channel.
  • the sample application region comprises a filter element for removing particulate matter from a sample (e.g. cells and organelles in a blood sample, or food particles or epithelial cells in a saliva sample
  • a wick as described above serves both as a sample application region and as filter.
  • the length of the channel connecting the sample application region and the reaction chamber is determined by the design of the cartridge and is typically limited such that the volume of the channel is between 0.1 and 2 ⁇ l.
  • the diameter of the channel is typically between 50 ⁇ m and 500 ⁇ m and depends from factors such as the amount of sample fluid available, the viscosity of the sample fluid or the presence of particulate matter in the sample fluid. Note that the channel may have different width and height.
  • the channel may optionally comprise reagents and buffering compounds.
  • a channel may, according to a particular embodiment, have bifurcations to distribute a sample to a plurality of reaction chambers, e.g. for the independent detection of different blood markers or different drugs of abuse.
  • the reaction chamber is the part of the cartridge wherein the reaction of an analyte or analyte analogue is performed, such as an enzymatic assay or a binding assay of an analyte with a probe.
  • probes are antibodies or oligonucleotides.
  • the cartridges of the present invention are typically used for performing sandwich immunoassays (e.g. cardiovascular markers in blood) or competitive immunoassays (drugs of abuse in sputum).
  • the detection of the analyte reaction equally takes place within the reaction chamber, accordingly functioning also as a detection chamber. Although this is not a prerequisite for the cartridges and methods of the present invention, the combined reaction and detection in the same chamber, reduces the size of a sample that is needed.
  • a binding assay probes or analyte analogues are bound to a detectable label.
  • the detectable label is a magnetic particle.
  • the sample application region (and the filter if present), the channel and the reaction chamber define the size of the sample volume required to fill the cartridge such that the reaction chamber is completely filled with sample fluid. Typically, this volume ranges from about 10 ⁇ l to about 100 ⁇ l.
  • a first sensing zone (7) is located in the sample application region or adjacent to the sample application region (i.e. in the proximal region (31) of the channel), such that upon, or immediately after the application of a liquid, its presence is recorded.
  • This sensing zone when positioned in the sample application region, can be positioned e.g. at the wall or the bottom of a depression, or can be positioned before or after a filter if such an element is present.
  • Fig. 2 Alternatively the sensing zone (7) is located at the proximal part (31) of the channel (3).
  • this refers to a position in the channel such that after application of 10, 5 or even 1 % of the required sample volume for an assay, liquid is recorded by the sensing zone in this proximal part of the channel.
  • Required sample volume refers to the volume needed to fill the channel and the reaction chamber, optionally further including the volume that remains in the sample application region (e.g. liquid attached to the walls or needed to wet a filter if present).
  • the sensing zone (7) accordingly records the application of a sample in a device.
  • a plurality of sensing zones can be provided in the channel to monitor and indicate the flow of the sample into the channel.
  • a further sensing zone (6) which is optionally present in the cartridge, is located at the entrance of the reaction chamber or in the distal part (32) of the channel. This zone records the entry of the sample in the reaction chamber. This event can be used to start within the device functions such as mixing of reagents and probes, in order to condition the sample for the subsequent assay.
  • a further sensing zone (5) is located at the exit of the reaction chamber, in the distal part of the reaction chamber, at the exit of the reaction chamber or optionally in a channel downstream of the reaction chamber. This sensing zone records the complete filling of the reaction chamber. This event can be used to start one or more functions within the device, including mixing, binding of probe and reagent, washing steps, and detection steps.
  • a sensor measures a change in an electric property, such a change in conductivity or in impedance upon the presence of an aqueous liquid between two electrodes.
  • a change in capacitance is measured.
  • the detection with a sensor is based on an optical detection (surface or bulk effect) and measures for example a change in surface reflection (e.g. Frustrated Total Internal Reflection), diffraction, refraction, absorbance or a change in absorbance maximum. Detection can take place in the visible part of the spectrum or at the infrared or UV region.
  • the cartridges and methods of the present invention are suitable for colourless
  • sample fluids e.g. saliva
  • coloured sample fluids e.g. blood or urine
  • devices for assaying blood can be equally used for other liquids which are essentially colourless, such as sputum, by applying a detectable agent (visible dye, fluorophore, phosphorophore) at the sample application zone or in a filter such that the dye dissolves upon contact with the sample liquid and generates a coloured liquid.
  • a detectable agent visible dye, fluorophore, phosphorophore
  • another aspect of the present invention relates to a method for performing an assay in the above-described cartridge upon insertion in a diagnostic device. Generally, a sample is applied to the sample application region (2) and the contact of the sample fluid on the sensing zone (6) at the application region or at the proximal part 31 of the channel (3) connecting the sample application region to the reaction chamber, is recorded.
  • the user of the device can be notified of the proper application of the sample fluid by a message on a display, a light signal or a sound signal when the sample fluid contacts the sensing zone.
  • the absence of such as signal with a predetermined time as indicated in the instructions of the device warns the user of a deficiency in the sample application.
  • the device gives a warning to the user when the signal is absent for a predetermined time after detected application of the sample to the cartridge.
  • the signal can be used for two alternatives instructions. In a first setting the warning sign automatically results in an abortion of the assay. In a second setting, the warning signs allows the user to apply within a predetermined time period a further amount of sample, whereafter the assay can continue. If however, the further amount of sample is not applied within this predetermined time period, the assay will be aborted.
  • the time between the application of a sample (e.g. applying a pricked finger) and such signal depends on factors such as the time needed to permeate through a filter, the viscosity of the sample and the position of the sensing zones.
  • the presence of the sample liquid on the sensing zone (7) at the inlet of the reaction chamber is recorded. This indicates that the sample has properly migrated from the application region into the channel.
  • additional sensing zones can be provided along channel (3) to calculate the flow speed in such tubular element. A lower speed can be indicative of obstruction in the cartridge, excessive particulate matter in the sample, or a too high viscosity of a sample fluid.
  • a signal can be given that the sample successfully reached sensing zone (6), or a warning sign can be given if the time lapsed between the contact of the liquid with sensing zone (6) and (7) is above a predetermined time period.
  • the filling of the reaction chamber is recorded by the presence of liquid at the sensing zone (5) at the exit of the reaction chamber.
  • the assay in the reaction chamber is started (i.e. the sample liquid is sensed at zone (7) and (5) and the period between detection at zone (7) and zone (5) does not exceed a predetermined time).
  • the timely filling of the reaction chamber can be notified to the user with a signal.
  • a warning signal can be given, requesting supplementary sample liquid, or the further operation of the assay can be stopped.
  • the above outlined method allows the detection of sample application to a cartridge. At that moment a timer can start running in the device. The wetting sensors at the exit of the reaction chamber should then detect the sample fluid within a predefined time. If that is not the case the analyser can go in a out-of-control handling mode. At this point two events are possible:
  • the device is provided with a data processing unit (10) which records and calculates the time between the wetting of the different sensing zone.
  • This data processing unit interacts with the control elements (91) of the device to decide on starting, continuing or aborting an assay, depending upon the moment at which the liquid is detected by the different sensing zones.
  • sensing zone 6 and 7 allow to automatically ready the device for an assay procedure, more particularly to start reagent mixing (by e.g. magnetic actuation) as soon as wetting of both sensing zones 6 and 7 is detected.
  • Starting of the actuation procedure can also be started after a predetermined time after the wetting of sensing zone 6 or 5, in order to allow the dry beads and reagents to dissolve in the sample fluid.
  • An automatic and predefined start of the actuation procedure can be of importance to get a reliable result with low assay-to-assay variability, especially for assays where binding kinetics indicate that the biological reaction is, or may not, be at equilibrium during the assay.
  • Other arrangements of the systems and methods embodying the invention will be obvious for those skilled in the art.
  • Cartridges equipped with a sensing zone for detecting the presence of a sample liquid can also be used to ensure the proper use of cartridges comprising biological materials and reagents which may be prone to light, humidity and heath.
  • cartridges are stored prior to their use in a packaging in a environment with a controlled temperature and atmosphere.
  • reagents in the cartridge may become subject to humidity, moisture, oxidising conditions and heat, and the assay should be completed within a certain time period to assure that the reagents do not decompose.
  • a further aspect of the invention relates to device comprising a sensor for the insertion of a cartridge, a cartridge comprising a sensing zone for the detection of a sample liquid and a clock measuring the time between the insertion of the cartridge in the device and the application of the sample. If a too long time period is recorded between the two above events, a warning signal is given to the user and/or the assay is stopped.
  • any of the sensing zones as described in the cartridges of the present invention can be used.
  • the sensing zone detection the filling of the reaction chamber is suitable for this purpose.
  • the insertion of the cartridge can be recorded by any means known in the art, for example by a mechanical switch in the device which is activated upon physical contact with the cartridge, or by the presence of a strip of conductive material on the cartridge which fits with an interrupted electrical circuit in the device.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne des cartouches (1) destinées à des dispositifs de diagnostique comprenant une zone d'application (2) d'un fluide échantillon, une chambre de réaction (4) et un canal (3) reliant la zone d'application à la chambre de réaction. Le dispositif comprend, en outre, des capteurs (5, 6, 7) destinés à détecter l'application d'un échantillon et le remplissage de la chambre de réaction.
PCT/IB2010/052015 2009-05-20 2010-05-07 Dispositif de diagnostique à détecteur d'application d'échantillon WO2010133997A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09160784.6 2009-05-20
EP09160784 2009-05-20

Publications (1)

Publication Number Publication Date
WO2010133997A1 true WO2010133997A1 (fr) 2010-11-25

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PCT/IB2010/052015 WO2010133997A1 (fr) 2009-05-20 2010-05-07 Dispositif de diagnostique à détecteur d'application d'échantillon

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013111042A1 (fr) * 2012-01-24 2013-08-01 Koninklijke Philips N.V. Cartouche de traitement d'un fluide
WO2018052481A1 (fr) * 2016-09-13 2018-03-22 Insight Instruments, Inc. Dosages homogènes et hétérogènes et systèmes de détermination de biomarqueurs oculaires
WO2020032958A1 (fr) 2018-08-09 2020-02-13 Hewlett-Packard Development Company, L.P. Commande de chambre réactionnelle basée sur la conductivité

Citations (9)

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Publication number Priority date Publication date Assignee Title
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
EP0774657A2 (fr) * 1995-11-15 1997-05-21 NIHON MEDI-PHYSICS Co., Ltd. Appareil et procédé pour la détection d'un liquide
WO2003091717A1 (fr) * 2002-04-25 2003-11-06 Home Diagnostics, Inc. Systemes et procedes de detection de glucose sanguin
EP1541998A1 (fr) * 2002-07-25 2005-06-15 ARKRAY, Inc. Procede et dispositif d'analyse d'echantillon
US20050220668A1 (en) * 2004-04-06 2005-10-06 Bio/Data Corporation Disposable test device with sample volume measurement and mixing methods
US20070205114A1 (en) * 2006-03-01 2007-09-06 Mathur Vijaywanth P Method of detecting biosensor filling
WO2009057024A1 (fr) * 2007-10-29 2009-05-07 Koninklijke Philips Electronics N. V. Cartouche de biocapteur à réflexion interne totale frustrée
WO2009125676A1 (fr) * 2008-04-09 2009-10-15 コニカミノルタエムジー株式会社 Système d'inspection
EP2168682A1 (fr) * 2008-09-29 2010-03-31 FUJIFILM Corporation Procédé de réaction et appareil de réaction

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
EP0774657A2 (fr) * 1995-11-15 1997-05-21 NIHON MEDI-PHYSICS Co., Ltd. Appareil et procédé pour la détection d'un liquide
WO2003091717A1 (fr) * 2002-04-25 2003-11-06 Home Diagnostics, Inc. Systemes et procedes de detection de glucose sanguin
EP1541998A1 (fr) * 2002-07-25 2005-06-15 ARKRAY, Inc. Procede et dispositif d'analyse d'echantillon
US20050220668A1 (en) * 2004-04-06 2005-10-06 Bio/Data Corporation Disposable test device with sample volume measurement and mixing methods
US20070205114A1 (en) * 2006-03-01 2007-09-06 Mathur Vijaywanth P Method of detecting biosensor filling
WO2009057024A1 (fr) * 2007-10-29 2009-05-07 Koninklijke Philips Electronics N. V. Cartouche de biocapteur à réflexion interne totale frustrée
WO2009125676A1 (fr) * 2008-04-09 2009-10-15 コニカミノルタエムジー株式会社 Système d'inspection
EP2168682A1 (fr) * 2008-09-29 2010-03-31 FUJIFILM Corporation Procédé de réaction et appareil de réaction

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013111042A1 (fr) * 2012-01-24 2013-08-01 Koninklijke Philips N.V. Cartouche de traitement d'un fluide
CN104080535A (zh) * 2012-01-24 2014-10-01 皇家飞利浦有限公司 用于处理流体的盒
US9557287B2 (en) 2012-01-24 2017-01-31 Koninklijke Philips N.V. Cartridge for processing a fluid
WO2018052481A1 (fr) * 2016-09-13 2018-03-22 Insight Instruments, Inc. Dosages homogènes et hétérogènes et systèmes de détermination de biomarqueurs oculaires
WO2020032958A1 (fr) 2018-08-09 2020-02-13 Hewlett-Packard Development Company, L.P. Commande de chambre réactionnelle basée sur la conductivité
EP3775832A4 (fr) * 2018-08-09 2021-03-31 Hewlett-Packard Development Company, L.P. Commande de chambre réactionnelle basée sur la conductivité

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