WO2010098872A1 - Réduction de la cellulite - Google Patents

Réduction de la cellulite Download PDF

Info

Publication number
WO2010098872A1
WO2010098872A1 PCT/US2010/000585 US2010000585W WO2010098872A1 WO 2010098872 A1 WO2010098872 A1 WO 2010098872A1 US 2010000585 W US2010000585 W US 2010000585W WO 2010098872 A1 WO2010098872 A1 WO 2010098872A1
Authority
WO
WIPO (PCT)
Prior art keywords
topical composition
cellulite
body part
subject
oil
Prior art date
Application number
PCT/US2010/000585
Other languages
English (en)
Inventor
John R. Hill
Original Assignee
Hill John R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hill John R filed Critical Hill John R
Publication of WO2010098872A1 publication Critical patent/WO2010098872A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation

Definitions

  • the invention relates to devices (and associated methods) adapted to apply fluid to external portions of a subject.
  • certain embodiments are adapted to apply a lower alcohol or alcohols to portions of a subject for subsequent evaporation and at least the appearance of the reduction of cellulite on a body part of the subject.
  • Cellulite describes a condition that occurs in men and women where the skin of the lower limbs, abdomen, and pelvic region becomes dimpled after puberty. The term was first used in the 1920s and began appearing in English language publications in the late 1960s, the earliest reference in Vogue magazine, "Like a swift migrating fish the word cellulite has suddenly crossed the Atlantic.”
  • Descriptive names for cellulite include orange peel syndrome, cottage cheese skin, the mattress phenomenon, and hail damage. Synonyms include: adiposis edematosa, dermopanniculosis deformans, status protrusus cutis, and gynoid lipodystrophy. Cellulite is unrelated to cellulitis, which is infection of the skin and its underlying connective tissue.
  • Cellulite is not related to being overweight; average and underweight people also get cellulite. However, dietary factors may be involved.
  • One plausible explanation - which also explains why very few men suffer from cellulite - is based on the composition and behavior of women's fat cells and the connective tissue that holds them in place. Very simply, a woman's connective tissue is very inflexible, so as females gain weight their fat cells expand, and tend to bulge upwards towards the surface of the skin, giving the classic orange-peel appearance of cellulite. In men, not only is there generally less fat on the thighs, but also the outer skin is thicker and thus obscures what is happening to any surplus fat below.
  • the causes are poorly understood, and several changes in metabolism and physiology may cause cellulite or contribute to cellulite. Among these are a disorder of water metabolism, abnormal hyper polymerization of the connective tissue, and chronic venous insufficiency.
  • Gender race, biotype, a hormone receptor allele that determines the receptor number and sensitivity, distribution of subcutaneous fat, and predisposition to circulatory insufficiency have all been shown to contribute to cellulite.
  • topical cosmetic compositions for use in reducing at least the appearance of cellulite on a subject, the topical composition consisting of: from about 5% to about 25% by volume one or more low boiling point alcohols, from about 0% to about 20% one or more cooling sensate by volume, and from about 50% to about 75% water by volume; wherein the concentration of any single cooling sensate is a maximum of 10% of the topical composition.
  • Also disclosed is a method of reducing cellulite on a body part of a subject comprising: topically applying to the body part associated with cellulite a composition comprising an active ingredient and an inactive ingredient or ingredients, wherein the active ingredient consists of a lower alcohol or alcohols, and evaporating the active ingredient from the body part, so as to reduce the appearance of cellulite on the subject's body part.
  • the topical composition may be applied via an absorption means ⁇ e.g., gauze or swab impregnated with the topical composition), wherein at least part of the absorption means is configured to be releasable to absorb any topical composition applied to it and, in use, allow contact between a subject's skin and the topical composition; and wherein the absorption means is a flexible bandage configurable to closely fit one or more body parts of the subject.
  • the absorption means is a flexible, elastic bandage that creates its elasticity through the weave of the cloth fibers.
  • the absorption means preferably includes one or more absorption sections configured to be releasable in the absorption of the topical composition, and is further preferably configured to apply compression on the body part.
  • Each lower alcohol may be selected from the group consisting of methanol, ethanol, isopropanol, other suitably stable low boiling point alcohol, and mixtures thereof.
  • the cooling sensate may be, e.g., a compound selected from the group consisting of menthol, arnica oil, Lemon oil, rosemary oil, orange oil, peppermint oil, a volatile essential oil, tea tree oil, a manufactured chemical compound that provides a cooling sensation and mixtures of any thereof.
  • the inactive ingredients of the topical composition may include, e.g., components selected from the group consisting of surfactants, coloring agents, arnica, pain relief agents, anti-inflammatory agents, perfume, odor eliminators, stabilizers, and mixtures of any thereof.
  • topical composition in the manufacture of a cosmetic for use in the reduction of the appearance of cellulite in a subject.
  • a device for use with the invention preferably includes a topical composition and an absorption means; such that the topical composition includes one or more low boiling point alcohols, one or more cooling sensate and water; wherein the total concentration of low boiling point alcohols is between 5% and 25% of the topical composition; the total concentration of cooling sensate is up to 20% of the topical composition, and the concentration of any single cooling sensate is a maximum of 10% of the topical composition; and the water concentration is at least 50% of the topical composition, wherein at least part of the absorption means is configured to be releasable to absorb any topical composition applied to it and, in use, allow contact between a user's skin and the topical composition; and wherein said absorption means is a flexible bandage configured to closely fit one or more body parts of the user.
  • the application of the topical composition is accomplished by following steps: 1. Remove the presoaked bandage containing the topical composition from its (e.g., foil) packaging, thus exposing it to a free flow of air. (The topical composition will begin to evaporate thus causing evaporative cooling)
  • a plastic sheet may be provided to avoid staining furniture.
  • step 3 Leave bandage on as directed in step 2 for at least one, but preferably about two hours or until the bandage is dry.
  • the absorption means can come in any length (e.g., 3 meters) and can be in any width of absorption material.
  • the absorption apparatus may be used to apply compression, support for body part, and absorbing the topical composition. It may be elasticized by means of its material makeup and the pattern of the woven material it is comprised of.
  • the absorption means is an elasticized cotton, linen, flax, or gauze bandage that is porous enough for evaporative cooling to take place, and is intended to soak up the entire topical composition.
  • the topical composition is soaked into the absorption means and is intimately wrapped onto the skin, so that an immediate cooling sensation is felt due to the cooling sensate and a following drop in temperature is felt as a lasting effect.
  • the lower alcohol(s) (or "low boiling point alcohol(s)) evaporate from the bandage, thus cooling and drying the bandage and the skin it has been wrapped around.
  • the cooling sensate or sensates act to provide a cool feeling for the user initially until the evaporative properties of the topical composition decrease the temperature of the absorption material.
  • the cooling of a selected area lowers the blood and fluid flow into the injured area which reduces swelling. Cold also reduces the occurrence of muscle spasms following an injury.
  • the means for providing absorption of the topical composition can include, besides the herein described bandages and swabs, socks, t-shirts, and sleeveless shirts, shorts, pants, bandannas, beanies, and any other means of intimately applying the topical composition to the skin of the applicant.
  • the means can be a "patch" having a reservoir containing the topical composition.
  • the invention is intended to cool and preferably compress specific areas of a body and can be used for, e.g., cosmetic skin treatment.
  • the cosmetic skin treatments can include cellulite treatment, dermatological, and cosmetic cooling treatments. Hypothermic treatment, soft tissue injuries, arthritis, pain management, shin splints, acute injuries, post- and pre-exercise, and any other treatment that involves the need for cooling and compression.
  • the topical composition can be modified somewhat.
  • additives such as preservatives, coloring agents, perfumes and the like which are recognized as being conventional in the art of pharmaceutical compounding.
  • the skin shows pallor, lower temperature, and decreased elasticity after compression or muscular contraction. There is no visible Orange peel' roughness to the skin. Additional anatomical changes are detected by histopathology. Grade 3
  • Example II A topical composition (“bandage”) containing water, ethanol, rosemary oil, orange oil, and lemon oil (LISSE® cellulite ice wrap) was obtained from Xanamed of Sandton, South Africa. The subjects from Example I were directed to wrap the affected area (e.g., upper thigh) with 1 bandage making sure to overlap the bandage. The bandage was to be left on for at least one hour, and the bandages were to be used every other day. After a single use of the LISSE® product, cellulite was reduced by one grade in each of the subjects, and the results lasted for up to 24 hours. For 60% of the group, beneficial effects were noted for 48 hours.
  • bandage containing water, ethanol, rosemary oil, orange oil, and lemon oil
  • a topical composition having Rosemary Oil, Lemon Oil, Orange Oil, Ethanol and Water is made by admixing the following quantities of liquid ingredients with a mixer, and then soaking the bandages with the mixture, and packaging the drenched bandages into foil outer wrappers:
  • the batch size is indicated and the water to ethanol mix is about 20%.
  • the oil only makes up a small portion of the mix and is used for scent and stability of mix.
  • Example III a large cotton swab drenched with the topical composition is applied to female subjects suffering from cellulite. These subjects are directed to swab the affected area with the large cotton swab making sure to keep the affected area wet for at least one hour. The swabbing with the topical composition was to be used every other day. Cellulite is reduced in the subjects.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention porte sur des compositions cosmétiques topiques destinées à être utilisées pour la réduction de l'apparition de la cellulite chez un sujet, la composition topique consistant en : environ 5 % à environ 25 % en volume d'un ou plusieurs alcools à point d'ébullition faible, environ 0 % à environ 20 % en volume d'un ou plusieurs agents sensoriels de rafraîchissement, et d'environ 50 % à environ 75 % en volume d'eau ; la concentration de tout agent sensoriel de rafraîchissement représentant au maximum 10 % de la composition topique. L'invention porte également sur des méthodes permettant de réduire au moins l'apparition de la cellulite sur une partie du corps d'un sujet, la méthode consistant à : appliquer sur la partie du corps associée à la cellulite une composition topique comprenant un principe actif et un ingrédient ou des ingrédients inactifs, le principe actif consistant en un alcool inférieur ou des alcools inférieurs, et laisser évaporer le principe actif de la partie du corps, de façon à réduire l'apparition de la cellulite sur la partie du corps du sujet.
PCT/US2010/000585 2009-02-26 2010-02-26 Réduction de la cellulite WO2010098872A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15562009P 2009-02-26 2009-02-26
US61/155,620 2009-02-26

Publications (1)

Publication Number Publication Date
WO2010098872A1 true WO2010098872A1 (fr) 2010-09-02

Family

ID=42665820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/000585 WO2010098872A1 (fr) 2009-02-26 2010-02-26 Réduction de la cellulite

Country Status (1)

Country Link
WO (1) WO2010098872A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102614287A (zh) * 2011-10-20 2012-08-01 广州中医药大学 治疗急性软组织损伤的喷膜剂及其制备方法
ES2560091R1 (es) * 2014-01-25 2016-03-31 Asac Compañía De Biotecnologia E Investigación Sa Uso de las vendas elásticas para la fabricación de un producto en el tratamiento de la celulitis.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413519B1 (en) * 1996-12-20 2002-07-02 Parfums Christian Dior Use of an extract of the plant Terminalia catappa in the cosmetic and pharmaceutical fields, especially the dermatological field
US20060210512A1 (en) * 2005-03-21 2006-09-21 Joseph Luizzi Skin compositions including tensioning polymers
US20090017080A1 (en) * 2007-03-15 2009-01-15 Paul Robert Tanner Personal care kit having skin care compositions with a readily perceptible difference

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413519B1 (en) * 1996-12-20 2002-07-02 Parfums Christian Dior Use of an extract of the plant Terminalia catappa in the cosmetic and pharmaceutical fields, especially the dermatological field
US20060210512A1 (en) * 2005-03-21 2006-09-21 Joseph Luizzi Skin compositions including tensioning polymers
US20090017080A1 (en) * 2007-03-15 2009-01-15 Paul Robert Tanner Personal care kit having skin care compositions with a readily perceptible difference

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102614287A (zh) * 2011-10-20 2012-08-01 广州中医药大学 治疗急性软组织损伤的喷膜剂及其制备方法
ES2560091R1 (es) * 2014-01-25 2016-03-31 Asac Compañía De Biotecnologia E Investigación Sa Uso de las vendas elásticas para la fabricación de un producto en el tratamiento de la celulitis.

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