WO2009151604A1 - Procédés pour fabriquer des articles en céramique, comprenant des échafaudages en céramique pour la réparation osseuse - Google Patents
Procédés pour fabriquer des articles en céramique, comprenant des échafaudages en céramique pour la réparation osseuse Download PDFInfo
- Publication number
- WO2009151604A1 WO2009151604A1 PCT/US2009/003501 US2009003501W WO2009151604A1 WO 2009151604 A1 WO2009151604 A1 WO 2009151604A1 US 2009003501 W US2009003501 W US 2009003501W WO 2009151604 A1 WO2009151604 A1 WO 2009151604A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ceramic
- scaffold
- ceramic composition
- porous
- composition
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
- C04B38/04—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by dissolving-out added substances
- C04B38/045—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by dissolving-out added substances the dissolved-out substance being a monolitic element having approximately the same dimensions as the final article, e.g. a prepreg obtained by bonding together dissolvable particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
- C04B38/06—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances
- C04B38/061—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances by melting out
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/08—Methods for forming porous structures using a negative form which is filled and then removed by pyrolysis or dissolution
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
Definitions
- biodegradable macroporous ceramic scaffolds have been used as engineered grafts for tissue engineering, particularly bone tissue engineering.
- Such scaffolds typically are made with hydroxyapatite (HA) or tricalcium phosphate (TCP) , or a combination of HA and TCP, with additives such as silica, magnesium, sodium, potassium, and zinc.
- HA hydroxyapatite
- TCP tricalcium phosphate
- additives such as silica, magnesium, sodium, potassium, and zinc.
- the invention is a method for making a macroporous CaP scaffold having high interconnectivity and mechanical strength.
- a CaP scaffold is made by the negative replica method disclosed above by using a negative replica that is defined by a template comprising a multiplicity of discrete porogen particles.
- a hardening step utilizing an extraction solvent is performed prior to the final curing of the scaffold, typically prior to removal of the negative template from the ceramic composition.
- An illustrative preferred method for making the macroporous CaP scaffold is described in Example 1 below.
- the invention is a macroporous scaffold, such as a CaP scaffold, made by a negative replica method, which method includes a hardening step utilizing an extraction solvent that is performed prior to the final curing of the scaffold.
- the hardening of the ceramic composition that results due to the solvent extraction step of the presently disclosed methods relates to the difference in surface tension between the original liquid in the ceramic composition and the extraction solvent.
- the original liquid in a fluid ceramic composition is aqueous
- water has a relatively high surface tension compared to organic solvents, for example hexane, acetone, or alcohols such as ethanol .
- organic solvents for example hexane, acetone, or alcohols such as ethanol .
- the temperature of the ethyl alcohol may then be increased to a temperature above the melting temperature of the paraffin, which will cause the paraffin to melt.
- the ethyl alcohol and paraffin may be removed and replaced with successive treatments of higher concentration ethyl alcohol for further extraction of fluid from the ceramic composition, which is now a green body.
- the scaffold may be loaded with cells, such as mesenchymal or other stem cells, or with a growth factor, such as bone morphogenic protein (BMP) or an angiogenic growth factor such as vascular endothelial growth factor (VEGF) or transforming growth factor (TGF) .
- BMP bone morphogenic protein
- VEGF vascular endothelial growth factor
- TGF transforming growth factor
- the scaffold may also be loaded with a pharmaceutically active agent, such as an antibiotic or an analgesic.
- the CaP scaffold of the invention may have zones of different architectures, which can be used to control biodegradation, spatial and or temporal, of the implanted scaffold. This permits a temporally and spatially controlled osteogenesis .
- the architecture of the scaffold is arranged to form a biomimetic scaffold that resembles the architecture of bone.
- a macroporous scaffold is made having a multiplicity of zones, such as an inner zone and an outer zone.
- the inner zone has a higher porosity than that of the outer zone. In this way, the inner zone mimics the architecture of cancellous bone and the outer zone mimics the architecture of cortical bone.
- Another set of samples was prepared by directly filling the slurry into the polyethylene cylinder tubes, without prior filling of the tubes with paraffin beads. These molds, which were not cast upon a negative template, in order to make solid (non-porous) ceramic bodies for making nonporous ceramic articles .
- the maximum compressive strength of the dense ceramic scaffold and the two-zone ceramic scaffold was determined as described in Example 2 and was compared to the strength of cortical bone reported in An YH and Draughn, RA, "Mechanical Testing of Bone and the Bone-Implant Interface", CRC Press, Boca Raton, FL (2000) .
Abstract
La présente invention concerne des articles poreux et non poreux en céramique qui sont fabriqués par un procédé qui comprend une étape de durcissage dans laquelle le liquide d’une composition céramique contenant du liquide est extrait de la composition céramique par exposition de la composition céramique à un solvant dans lequel le liquide dans la composition est soluble avant que la composition céramique soit solidifiée en article de céramique final. Les articles poreux en céramique de phosphate de calcium de l’invention sont construits et caractérisés en ce qu’ils peuvent être utilisés en tant qu’implants pour réparer des défauts osseux.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/902,886 US20110052660A1 (en) | 2007-03-16 | 2010-10-12 | Ceramic scaffolds for bone repair |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13181008P | 2008-06-12 | 2008-06-12 | |
US61/131,810 | 2008-06-12 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/074,434 Continuation-In-Part US8114336B2 (en) | 2007-03-16 | 2008-03-04 | Methods for increasing the strength and controlling the architecture and composition of ceramic articles |
Publications (1)
Publication Number | Publication Date |
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WO2009151604A1 true WO2009151604A1 (fr) | 2009-12-17 |
Family
ID=41417013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/003501 WO2009151604A1 (fr) | 2007-03-16 | 2009-06-10 | Procédés pour fabriquer des articles en céramique, comprenant des échafaudages en céramique pour la réparation osseuse |
Country Status (1)
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WO (1) | WO2009151604A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112851198A (zh) * | 2021-03-16 | 2021-05-28 | 韩新民 | 一种陶粒砖的制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2939199A (en) * | 1952-08-11 | 1960-06-07 | Int Standard Electric Corp | Formation of ceramic mouldings |
US4327065A (en) * | 1979-04-30 | 1982-04-27 | Dardel Guy Von | Method of preparing silica aerogel |
US5525557A (en) * | 1993-01-07 | 1996-06-11 | Norton Company | High density green bodies |
US6368703B1 (en) * | 1999-08-17 | 2002-04-09 | Phillips Plastics Corporation | Supported porous materials |
US6451059B1 (en) * | 1999-11-12 | 2002-09-17 | Ethicon, Inc. | Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds |
US20030114936A1 (en) * | 1998-10-12 | 2003-06-19 | Therics, Inc. | Complex three-dimensional composite scaffold resistant to delimination |
US6673285B2 (en) * | 2000-05-12 | 2004-01-06 | The Regents Of The University Of Michigan | Reverse fabrication of porous materials |
US20050209704A1 (en) * | 2002-03-14 | 2005-09-22 | Maspero Fabrizio A | Porous biocompatible implant material and method for its fabrication |
-
2009
- 2009-06-10 WO PCT/US2009/003501 patent/WO2009151604A1/fr active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2939199A (en) * | 1952-08-11 | 1960-06-07 | Int Standard Electric Corp | Formation of ceramic mouldings |
US4327065A (en) * | 1979-04-30 | 1982-04-27 | Dardel Guy Von | Method of preparing silica aerogel |
US5525557A (en) * | 1993-01-07 | 1996-06-11 | Norton Company | High density green bodies |
US20030114936A1 (en) * | 1998-10-12 | 2003-06-19 | Therics, Inc. | Complex three-dimensional composite scaffold resistant to delimination |
US6368703B1 (en) * | 1999-08-17 | 2002-04-09 | Phillips Plastics Corporation | Supported porous materials |
US6451059B1 (en) * | 1999-11-12 | 2002-09-17 | Ethicon, Inc. | Viscous suspension spinning process for producing resorbable ceramic fibers and scaffolds |
US6673285B2 (en) * | 2000-05-12 | 2004-01-06 | The Regents Of The University Of Michigan | Reverse fabrication of porous materials |
US20050209704A1 (en) * | 2002-03-14 | 2005-09-22 | Maspero Fabrizio A | Porous biocompatible implant material and method for its fabrication |
Non-Patent Citations (1)
Title |
---|
ZOLLFRANK C. ET AL.: "Biomorphous SiOC/C-Ceramic Composites from Chemically Modified Wood Templates.", JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, vol. 24, February 2004 (2004-02-01), pages 479 - 487 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112851198A (zh) * | 2021-03-16 | 2021-05-28 | 韩新民 | 一种陶粒砖的制备方法 |
CN112851198B (zh) * | 2021-03-16 | 2021-08-17 | 韩新民 | 一种陶粒砖的制备方法 |
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