WO2009146881A2 - Dépistage du cancer du sein à l’aide d’un dispositif d’immobilisation en forme d’entonnoir - Google Patents

Dépistage du cancer du sein à l’aide d’un dispositif d’immobilisation en forme d’entonnoir Download PDF

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Publication number
WO2009146881A2
WO2009146881A2 PCT/EP2009/003921 EP2009003921W WO2009146881A2 WO 2009146881 A2 WO2009146881 A2 WO 2009146881A2 EP 2009003921 W EP2009003921 W EP 2009003921W WO 2009146881 A2 WO2009146881 A2 WO 2009146881A2
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WO
WIPO (PCT)
Prior art keywords
microwave
signal
breast
antenna
microwave signal
Prior art date
Application number
PCT/EP2009/003921
Other languages
German (de)
English (en)
Other versions
WO2009146881A3 (fr
Inventor
René KRUPKA
Jürgen CARSTENS
David Picken
Jan Prochnow
Original Assignee
Rohde & Schwarz Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohde & Schwarz Gmbh & Co. Kg filed Critical Rohde & Schwarz Gmbh & Co. Kg
Priority to EP09757264A priority Critical patent/EP2291116A2/fr
Publication of WO2009146881A2 publication Critical patent/WO2009146881A2/fr
Publication of WO2009146881A3 publication Critical patent/WO2009146881A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/02—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S13/00
    • G01S7/03—Details of HF subsystems specially adapted therefor, e.g. common to transmitter and receiver
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  using microwaves or terahertz waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00—Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S13/00—Systems using the reflection or reradiation of radio waves, e.g. radar systems; Analogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
    • G01S13/88—Radar or analogous systems specially adapted for specific applications

Definitions

  • the invention relates to devices and methods for the examination of objects, in particular breast tissue.
  • mammograms are made to examine breast tissue. These are characterized by a low accuracy and a high
  • US 5,704,355 shows a system for the detection of breast cancer, which uses an antenna in direct contact with the breast.
  • the disadvantage here is a low positioning accuracy of the antenna. This allows the breast to slip against the antenna during the examination.
  • US 2006/0173307 A1 shows a device for positioning, fixation and ultrasound-based examination of breast tissue.
  • the disadvantage here is the low contrast of the resulting images and the high demands on the staff evaluating the images.
  • the invention is based on the object, a
  • a first device for examining breast tissue comprises a funnel-shaped holder, a microwave transmitter, a microwave receiver, at least one antenna device and a control device.
  • An inside of the holder picks up the breast.
  • the antenna device is arranged on an outer side of the holder.
  • the controller controls the microwave transmitter and the microwave receiver.
  • the microwave transmitter sends a microwave signal into the breast by means of the antenna device.
  • the microwave receiver receives the microwave signal scattered from the breast by means of the antenna device.
  • the controller determines based on the received microwave signal information regarding the breast tissue. Thus, a slippage of the breast can be prevented at high examination quality.
  • the antenna device is arranged on the outside of the holder radially around the funnel-shaped holder and / or axially along the funnel-shaped holder.
  • the control device preferably controls the position of the antenna device on the outside of the holder.
  • the control device focuses by means of the antenna device preferably the emission and / or the Receiving the microwave signal to a location in the chest.
  • the examination quality is further increased.
  • the device further includes an excitation device.
  • the excitation device loads the chest mechanically.
  • the control device preferably controls the excitation device.
  • additional information concerning the internal structure of the breast can be determined.
  • the control device preferably controls the excitation device in such a way that the microwave transmitter sends the microwave signal successively into the breast in at least two different load states of the breast. This ensures an accurate examination with simple operation.
  • a second device for the examination of objects includes a microwave transmitter, a microwave receiver, at least one antenna device and a control device.
  • the controller controls the microwave transmitter and the
  • the microwave transmitter includes a modulation device.
  • the microwave transmitter generates a modulated signal by means of the modulation device
  • the microwave receiver includes a demodulation device.
  • the microwave receiver receives the microwave signal scattered by the object to be examined by means of the antenna device and demodulates it by means of the demodulation device.
  • the controller determines information from the modulation of the received microwave signal concerning the object of investigation. Thus, a very high accuracy of the investigation can be achieved.
  • the modulation is preferably carried out by means of a pseudorandom sequence. This results in clear results of the investigation.
  • the modulated microwave signal is preferably a mobile radio signal, in particular a GSM signal or a UMTS signal.
  • a mobile radio signal in particular a GSM signal or a UMTS signal.
  • the controller controls the microwave transmitter and the
  • the microwave transmitter transmits a first microwave signal into the breast by means of the antenna device.
  • the microwave receiver receives the first microwave signal scattered from behind the breast and the chest by means of the antenna device.
  • the microwave transmitter transmits a second microwave signal into the breast by means of the antenna device.
  • the microwave receiver receives the second microwave signal scattered from the breast by means of the antenna device.
  • the control device determines a fault model on the basis of the received first microwave signal.
  • the controller corrects the received second microwave signal based on the
  • the controller determines based on the corrected second microwave signal information regarding the breast tissue. This allows particularly accurate examination results to be achieved.
  • the first microwave signal preferably has a lower frequency than the second microwave signal.
  • the first measurement can be done in a very short time. Furthermore, a large penetration depth is achieved. A comparison with known anatomical data regarding the ribs is thus possible.
  • the device includes a first microwave transmitter, a first microwave receiver, a second microwave transmitter and a second microwave receiver.
  • the first microwave transmitter preferably transmits the first microwave signal.
  • the first microwave receiver preferably receives the first microwave signal.
  • the second microwave transmitter preferably transmits the second microwave signal.
  • the second microwave receiver preferably receives the second microwave signal.
  • the device preferably includes a first antenna device and a second antenna device.
  • the first antenna device preferably processes the first microwave signal.
  • the second antenna device preferably processes the second microwave signal.
  • Fig. 1 shows a first embodiment of the device according to the invention
  • Fig. 2 shows a second embodiment of the device according to the invention
  • FIG. 3 shows a third embodiment of the device according to the invention.
  • FIG. 5 shows a fifth embodiment of the device according to the invention.
  • FIG. 6 shows a sixth embodiment of the device according to the invention.
  • FIGS. 1-6 show a third embodiment of the method according to the invention.
  • FIGS. 1-6 show a third embodiment of the method according to the invention.
  • FIGS. 8-10 show a third embodiment of the method according to the invention.
  • FIG. 1 shows a first embodiment of the device according to the invention.
  • An apparatus for examining breast tissue includes an antenna device 10, a microwave transmitter 2, a microwave receiver 3, a controller 4, a funnel-shaped holder 15 and an antenna holder 16.
  • the antenna device 10 is electrically connected to the microwave transmitter 2 and the microwave receiver 3.
  • the microwave transmitter 2 and the microwave receiver 3 are electrically connected to the
  • Control device 4 connected.
  • the controller 4 is electrically connected to the antenna holder 16.
  • the antenna device 10 is mechanically connected to the antenna holder 16. Furthermore, the antenna device 10 is in contact with the funnel-shaped holder 15 or is located at a small distance to this.
  • the breast not to be examined which is not shown here, is received and fixed by the funnel-shaped holder 15.
  • the control device 4 causes the microwave transmitter 2 to generate a microwave signal and send it by means of the antenna device 10 through the funnel-shaped holder 15 in the chest.
  • the Microwave signal is scattered from the breast and received by the microwave receiver 3 through the funnel-shaped holder 15 by means of the antenna device 10.
  • the received signal is forwarded to the control device 4.
  • the antenna holder 16 is configured such that the antenna device 10 can be positioned at different positions on the outside of the funnel-shaped holder 15. In this case, the antenna device 10 can be moved axially along the outside of the funnel-shaped holder 15. Furthermore, the antenna device 10 can be moved radially around the outside of the funnel-shaped holder 15 by rotation of the antenna holder 16. In this case, the antenna holder 16 rotates with respect to the funnel-shaped holder 15 and the breast to be examined.
  • the antenna device 10 For complete examination of the breast to be examined, the antenna device 10 is successively brought to a plurality of different positions 11, 12, 13 on the outside of the funnel-shaped holder 15. At each position, a measurement is performed. Based on the results of the various measurements, the controller 4 determines information concerning the breast to be examined. For example, the internal structure of the breast to be examined can be determined.
  • the antenna device 10 consists of a single antenna, a plurality of individual antennas or an antenna array.
  • the higher the number of individual antennas within the antenna device 10, the higher the spatial resolution at a given number of positions 11, 12, 13 of the antenna device 10. 2 a second embodiment of the device according to the invention is shown.
  • the embodiment shown here corresponds in large parts to the embodiment shown in FIG.
  • the antenna mount 16, the microwave transmitter 2, the microwave receiver 3 and the control device 4 have not been shown here for the sake of clarity.
  • the funnel-shaped holder 15 is placed on a breast 20.
  • the holder 15 is shown transparent.
  • negative pressure which is generated by the line 21, the breast 20 is sucked into the holder 15 and fixed thereto.
  • an excitation device 22 is further attached on the outside of the funnel-shaped holder 15.
  • the excitation device 22 is designed such that the breast 20 can be subjected to a variable mechanical load. This is achieved, for example, by the excitation device 22 pressing on the breast by means of a punch through a recess in the funnel-shaped holder 15. The passage of the punch through the holder 15 is largely airtight.
  • the excitation device 22 is also controlled by the control device 4, not shown here.
  • the funnel-shaped holder 15 is placed on the breast 20.
  • the trapped between the chest 20 and the funnel-shaped support 15 is air by means of the line 21st evacuated.
  • the breast 20 is sucked into the holder 15 and fixed thereto.
  • the antenna device 10 is brought into different positions 11, 12, 13 while measurements are being taken.
  • a plurality of different load conditions of the chest 20 are prepared and for each load condition a separate measurement is performed. Since different types of tissue, in particular tumors, 20 have different elasticities within the breast, these different types of tissue can be detected by changing mechanical stress on the breast.
  • an excitation can be done by means of ultrasound.
  • Fig. 3 shows a third embodiment of the device according to the invention. Also, this embodiment largely corresponds to the embodiments shown in Fig. 1 and Fig. 2. For the sake of clarity, only the funnel-shaped holder 15 and the antenna device 30 were shown here.
  • Antenna device 30 is embodied here as an antenna array mounted on the outside of the funnel-shaped holder 15.
  • An antenna mount 16 is not necessary here since the use of the antenna array makes mechanical movement of the antenna device 30 unnecessary.
  • the funnel-shaped holder 15 is held by a holding arm 31 here.
  • the holding arm 31 is connected to a base 32.
  • the holding arm 31 is used for the secure positioning and fixing of the funnel-shaped holder 15. It can be brought by the operator by hand in position and locked.
  • the holding arm 31 has servo motors which enable automated positioning controlled by the control device 4.
  • a fourth embodiment of the device according to the invention is shown.
  • a two-stage measurement is used to achieve an increased accuracy of the measurement.
  • further antenna devices 42, 43, 44, 45 are arranged there.
  • the antenna devices 40, 41, 42, 43, 44, 45 are, as shown in Fig. 1, attached to an antenna holder 16, not shown here. As shown there, the individual antenna devices can be brought to different positions on the outside of the funnel-shaped holder 15.
  • ribs 46 below the breast 20 are ribs 46 in the rib cage.
  • the ribs 46 are made of bone and thus have a considerably greater density than the breast 20.
  • Each individual rib has a diameter which is clearly above the resolution limit of the examination. Even under difficult conditions, the ribs are 46 thus easy to detect. From anatomical a priori information, the significant density difference of the ribs 46 and the surrounding tissue is known. The rough position of the ribs 46 below the breast 20 is known. This information is used to increase the accuracy of the investigation.
  • the control device 4 causes the microwave transmitter 2 to send a first microwave signal into the breast by means of at least one first antenna device 40.
  • a first microwave signal For this first microwave signal, a low microwave frequency is used.
  • the first microwave signal penetrates deep into the tissue due to its low frequency. It is scattered by the breast 20 and by the ribs 46.
  • the microwave receiver 3 receives the scattered microwave signal by means of the antenna device 40 and forwards it to the control device 4 for evaluation. This measurement is repeated for a plurality of positions of the antenna device 40.
  • the controller 4 determines a perturbation model, which primarily contains reflection at the top and bottom of the skin layer surrounding the outside of the breast.
  • the control device 4 causes the microwave transmitter 2 or a second, not shown, microwave transmitter to a second Send microwave signal by means of a second antenna device 41 or a plurality of second antenna means 41, 43, 45 in the breast 20.
  • the use of a second microwave transmitter reduces the demands on the microwave transmitters, since the microwave transmitters thus each have to spend only a single frequency.
  • second antenna devices 41, 43, 45 makes it possible to adapt the antenna devices 41, 43, 45 to the respectively transmitted microwave frequency. This increases the measurement accuracy and reduces the space requirement of the antenna devices 40, 41, 42, 43, 44, 45.
  • the second microwave signal has a much higher frequency than the first microwave signal.
  • the penetration depth is thus significantly lower.
  • a scattering of the second microwave signal at the ribs 46 thus almost no longer occurs.
  • the microwave receiver 3 or an alternative unillustrated second microwave receiver receives the second microwave signal by means of the antenna device 41 or antenna devices 41, 43, 45 and forwards it to the control device 4.
  • the control device 4 uses the fault model, which was generated on the basis of the received first microwave signal, to correct the received second microwave signal. This can be used to compensate for disturbing influences, eg of the skin layer. Based on the corrected second microwave signal, the control device 4 finally determines information regarding the breast to be examined.
  • Fig. 5 shows a fifth embodiment of the device according to the invention. This embodiment is particularly concerned with the repeated accurate positioning of the funnel-shaped holder 15 on the breast 20.
  • markings 51 are applied to the breast 20 or in the vicinity of the breast 20. This is advantageously done by means of a long-lasting color.
  • a camera 50 is mounted on its front side, which looks through an air-tightly closed opening in the holder 15 in the direction of the breast 20.
  • the marks 51 in the current image of the camera are compared with recorded images.
  • An identical position of the markers 51 is made by either manual or automatic positioning of the holder 15.
  • FIG. 6 a sixth embodiment of the device according to the invention is shown.
  • the embodiment shown here largely corresponds to the embodiment shown in FIG. Of the
  • microwave transmitter 2 additionally includes a modulation device 5.
  • the microwave receiver additionally includes a demodulation device 6.
  • the modulation device modulates the microwave signal prior to transmission with a known signal, preferably with a pseudorandom sequence (PN sequence).
  • PN sequence pseudorandom sequence
  • the use of a mobile radio signal, in particular a GSM or UMTS signal is possible.
  • the signal used for the modulation is not periodic or has a period length which is significantly greater than the longest transmission time from the microwave transmitter 2 to the microwave receiver 3.
  • the modulated signal is sent from the microwave transmitter 2 into the chest. It is scattered from the breast. However, the breast is not homogeneous in structure. This leads to a superposition of several scattered microwave signals at the microwave receiver 3. Die
  • Demodulation device 6 in the microwave receiver 3 performs a demodulation of the signal.
  • a comparison of the transmitted microwave signal and the received microwave signal it is thus possible to deduce the internal structure of the breast.
  • a temporal resolution of the scattered microwave signals is possible by the modulation.
  • a correlation of the transmitted and the received microwave signal enables the determination of discrete scattering objects. This will be explained in more detail with reference to FIG. 7.
  • Fig. 7 shows several exemplary waveforms.
  • the first signal 70 corresponds to the modulation of a first microwave signal transmitted to the breast. Only the Values 1 and 0 are present. They are arranged in a random way.
  • the second signal 71 corresponds to the first signal 70 scattered by a first scattering object
  • the signal differs from the first signal 70 by a time shift which is less than one sample period. In the presentation, the signals do not differ. The scatter object is thus very close to the antenna.
  • the third signal 72 corresponds to the first signal 70 scattered by a second scattering object.
  • the signal differs from the first signal 70 by a time shift of 3 time units.
  • the scattering object is thus at a certain distance from the antenna.
  • the fourth signal 73 corresponds to the first signal 70 scattered by a third scattering object.
  • the signal differs from the first signal 70 by a time shift of 4 time units.
  • the scattering object is thus at a certain distance from the antenna.
  • the fifth signal 74 corresponds to the sum signal applied to the microwave receiver of the three scattered signals 71 to 73.
  • the summation signal was scaled again to the values 0 to 1.
  • intermediate values occur on.
  • the signal shape of the original signal 70 can still be recognized.
  • the value transitions are smooth.
  • the correlation signal 75 shows the result of such correlation.
  • the correlation maximum is offset by one time unit. This results in maxima of the correlation signal at the values 1, 4 and 5, which corresponds to the correlation maxima at the values 0, 3 and 4. From the correlation can thus be concluded on the time shift and thus on the position of the scattering objects.
  • FIG. 8 shows a first exemplary embodiment of the method according to the invention.
  • a funnel-shaped support is positioned over the patient's chest. For this purpose, for example, markings on the breast are detected with a camera and brought into coincidence with a reference recording.
  • the holder is placed on the chest.
  • the holder is fixed to the chest. This is done, for example, by means of a negative pressure generated within the holder. This one will evacuated by evacuating the space between the chest and the bracket.
  • a focusing or positioning of an antenna is performed.
  • microwave radiation transmitted or received by the antenna is concentrated to a specific volume of space within the breast. This can be done either by a physical movement of one or more antennas or by the use of several phase-shifter interconnected non-movable antennas.
  • a microwave signal is sent into the breast by means of the antenna. The breast scatters the microwave signal. The microwave signal is received by the antenna.
  • the fourth step 83 and fifth step 84 are repeated for a plurality of volume volumes within the breast.
  • the received microwave signals are evaluated in a sixth step 85. This information is determined regarding the internal structure of the breast.
  • Fig. 9 shows a second embodiment of the method according to the invention.
  • This embodiment corresponds in part to the embodiment shown in Fig. 8.
  • the steps 80 to 82 of FIG. 8 can optionally be preceded by the steps shown here.
  • a microwave signal is modulated.
  • the modulation takes place with a pseudorandom sequence (PN sequence).
  • PN sequence pseudorandom sequence
  • the use of a GSM signal or a UMTS signal or other mobile radio signal, in particular CDMA signal is possible. If it is a periodic sequence, the period length is significantly longer than twice the transmission time between the antenna and the chest.
  • the modulated microwave signal is sent to the breast.
  • the modulated microwave signal is scattered from the breast and received by the antenna.
  • the scattered microwave signal is demodulated. Steps 90-93 are repeated for a variety of volumes within the breast.
  • the received modulated microwave signal is evaluated. By correlating the transmitted modulated microwave signal and the received modulated microwave signal, temporal resolution can be achieved. This makes it possible to differentiate between different scatter objects.
  • a third embodiment of the method according to the invention is shown. This embodiment corresponds in part to the embodiment shown in Fig. 8. Thus, the steps 80 to 82 of FIG. 8 can optionally be preceded by the steps shown here.
  • a first step 100 positioning of an antenna or focusing takes place. This step corresponds to step 83 of FIG. 8.
  • a second step 101 a first step 100
  • Microwave signal sent to the chest The first microwave signal is scattered from the chest and underlying ribs.
  • the microwave signal scattered from the breast is received.
  • a third step 102 based on the received scattered first
  • Microwave signal determines a disorder model of the breast. This includes anatomical information, such as the typical bone density and the significant density change between the ribs and the surrounding tissue.
  • a second microwave signal is sent to the breast.
  • the second microwave signal is preferably higher in frequency than the first microwave signal. It thus has a lower penetration depth, but higher possible spatial resolution.
  • the second microwave signal is scattered from the chest. Only negligible signal components reach the ribs.
  • the second microwave signal scattered from the breast is received. Steps 100-103 are repeated for a plurality of volumes of space within the breast.
  • the received second microwave signals are corrected on the basis of the perturbation model or perturbation models.
  • the corrected second microwave signals are evaluated. Information concerning the internal structure of the breast is thus generated.

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

L’invention se rapporte à un dispositif permettant d’examiner du tissu mammaire et comprenant un dispositif d’immobilisation (15) en forme d’entonnoir, un émetteur micro-ondes (2), un récepteur micro-ondes (3), au moins un dispositif antenne (10) et un dispositif de commande (4). Une face interne du dispositif d'immobilisation (15) recouvre le sein. Le dispositif antenne (10) est disposé sur une face externe du dispositif d'immobilisation (15). Le dispositif de commande (4) pilote l’émetteur micro-ondes (2) et le récepteur micro-ondes (3). L’émetteur micro-ondes (2) envoie un signal micro-ondes dans le sein au moyen du dispositif antenne (10). Le récepteur micro-ondes (3) reçoit le signal micro-ondes diffusé par le sein au moyen du dispositif antenne (10). Le dispositif de commande (4) détermine les informations concernant le tissu mammaire à l’aide du signal micro-ondes reçu.
PCT/EP2009/003921 2008-06-02 2009-06-02 Dépistage du cancer du sein à l’aide d’un dispositif d’immobilisation en forme d’entonnoir WO2009146881A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09757264A EP2291116A2 (fr) 2008-06-02 2009-06-02 Dépistage du cancer du sein à l aide d un dispositif d immobilisation en forme d entonnoir

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102008026437 2008-06-02
DE102008026437.7 2008-06-02
DE102009007255A DE102009007255A1 (de) 2008-06-02 2009-02-03 Brustkrebserkennung mit Fixierungstrichter
DE102009007255.1 2009-02-03

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WO2009146881A2 true WO2009146881A2 (fr) 2009-12-10
WO2009146881A3 WO2009146881A3 (fr) 2010-01-28

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Cited By (4)

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WO2011101875A1 (fr) * 2010-02-18 2011-08-25 Metis S.R.L. Appareil pour la détection de la tonicité d'un tissu humain et/ou animal
EP2582304A4 (fr) * 2010-06-15 2015-04-29 Image Mining Inc Systèmes de référence pour une mammographie
WO2015136936A1 (fr) * 2014-03-12 2015-09-17 国立大学法人神戸大学 Procédé de tomographie par diffusion et dispositif de tomographie par diffusion
JPWO2017057524A1 (ja) * 2015-09-29 2018-08-02 国立大学法人神戸大学 画像化方法および画像化装置

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CN104473617B (zh) * 2014-11-10 2017-08-01 南方科技大学 生物体组织探测装置、***及方法
DE102016108022A1 (de) * 2016-04-29 2017-11-02 Claudia Resch Bilderzeugungsvorrichtung zur ortsauflösenden Vermessung von Änderungen der Dichte in 3-dimensionalen dielektrischen Objekten
GB201608687D0 (en) 2016-05-17 2016-06-29 Micrima Ltd A medical imaging system and method

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US5833633A (en) * 1992-12-21 1998-11-10 Artann Laboratories Device for breast haptic examination
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