WO2009126688A8 - Compositions et procédés nouveaux pour le traitement de maladies de nature immunitaire - Google Patents
Compositions et procédés nouveaux pour le traitement de maladies de nature immunitaire Download PDFInfo
- Publication number
- WO2009126688A8 WO2009126688A8 PCT/US2009/039868 US2009039868W WO2009126688A8 WO 2009126688 A8 WO2009126688 A8 WO 2009126688A8 US 2009039868 W US2009039868 W US 2009039868W WO 2009126688 A8 WO2009126688 A8 WO 2009126688A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- methods
- related diseases
- immune related
- novel compositions
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011504145A JP5770624B2 (ja) | 2008-04-09 | 2009-04-08 | 免疫関連疾患の治療のための新規組成物と方法 |
PL17152167T PL3208612T3 (pl) | 2008-04-09 | 2009-04-08 | Kompozycje i sposoby leczenia chorób o podłożu immunologicznym |
MX2013010169A MX364200B (es) | 2008-04-09 | 2009-04-08 | Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad. |
KR1020167036368A KR101855381B1 (ko) | 2008-04-09 | 2009-04-08 | 면역 관련 질병의 치료를 위한 신규한 조성물 및 방법 |
EP17152167.7A EP3208612B1 (fr) | 2008-04-09 | 2009-04-08 | Compositions et procédés pour le traitement de maladies liées au système immunitaire |
KR1020107025044A KR101692080B1 (ko) | 2008-04-09 | 2009-04-08 | 면역 관련 질병의 치료를 위한 신규한 조성물 및 방법 |
AU2009233708A AU2009233708B2 (en) | 2008-04-09 | 2009-04-08 | Novel compositions and methods for the treatment of immune related diseases |
ES09730709.4T ES2640533T3 (es) | 2008-04-09 | 2009-04-08 | Composiciones y métodos novedosos para el tratamiento de enfermedades relacionadas con la inmunidad |
SI200931728T SI2279412T1 (sl) | 2008-04-09 | 2009-04-08 | Novi sestavki in postopki za zdravljenje imunsko povezanih bolezni |
CA2719189A CA2719189C (fr) | 2008-04-09 | 2009-04-08 | Compositions et procedes nouveaux pour le traitement de maladies de nature immunitaire |
DK09730709.4T DK2279412T3 (en) | 2008-04-09 | 2009-04-08 | PRESENT UNKNOWN COMPOSITIONS AND PROCEDURES FOR TREATING IMMUNRATED DISEASES |
CN200980121734.2A CN102057272B (zh) | 2008-04-09 | 2009-04-08 | 用于免疫相关疾病的治疗的新组合物和方法 |
BRPI0906550A BRPI0906550B8 (pt) | 2008-04-09 | 2009-04-08 | Anticorpo anti-tigit, usos de um anticorpo anti-tigit e métodos in vitro para estimular a interação de cd226-pvr e/ou a interação de cd96-pvr, para aumentar ou estimular a proliferação de uma célula t ou a liberação de citocinas proinflamatórias por uma célula dendrítica, para aumentar ou estimular a resposta imune de célula t e para aumentar ou estimular a produção de citocinas proinflamatórias por uma célula dendrítica |
CN201910073153.1A CN110082533B (zh) | 2008-04-09 | 2009-04-08 | 用于免疫相关疾病的治疗的新组合物和方法 |
MX2010011088A MX2010011088A (es) | 2008-04-09 | 2009-04-08 | Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad. |
PL09730709T PL2279412T3 (pl) | 2008-04-09 | 2009-04-08 | Nowe kompozycje i sposoby leczenia chorób o podłożu immunologicznym |
EP09730709.4A EP2279412B1 (fr) | 2008-04-09 | 2009-04-08 | Compositions et procédés nouveaux pour le traitement de maladies de nature immunitaire |
KR1020187012359A KR101924831B1 (ko) | 2008-04-09 | 2009-04-08 | 면역 관련 질병의 치료를 위한 신규한 조성물 및 방법 |
KR1020187034436A KR20180132156A (ko) | 2008-04-09 | 2009-04-08 | 면역 관련 질병의 치료를 위한 신규한 조성물 및 방법 |
EP19181712.1A EP3605088A1 (fr) | 2008-04-09 | 2009-04-08 | Compositions et procédés pour le traitement de maladies liées au système immunitaire |
IL208285A IL208285A0 (en) | 2008-04-09 | 2010-09-21 | Novel compositions and methods for the treatment of immune related diseases |
IL228988A IL228988A (en) | 2008-04-09 | 2013-10-21 | Antibody preparations for the treatment of vaccine-related diseases |
AU2015202123A AU2015202123B2 (en) | 2008-04-09 | 2015-04-24 | Novel compositions and methods for the treatment of immune related diseases |
IL246293A IL246293B (en) | 2008-04-09 | 2016-06-16 | New preparations and methods for the treatment of vaccine-related diseases |
AU2017221784A AU2017221784B2 (en) | 2008-04-09 | 2017-08-30 | Novel compositions and methods for the treatment of immune related diseases |
IL264498A IL264498B (en) | 2008-04-09 | 2019-01-28 | New preparations and methods for the treatment of vaccine-related diseases |
AU2019257492A AU2019257492A1 (en) | 2008-04-09 | 2019-10-31 | Novel compositions and methods for the treatment of immune related diseases |
IL272817A IL272817A (en) | 2008-04-09 | 2020-02-20 | New preparations and methods for the treatment of vaccine-related diseases |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12353008P | 2008-04-09 | 2008-04-09 | |
US61/123,530 | 2008-04-09 | ||
US19427108P | 2008-09-26 | 2008-09-26 | |
US61/194,271 | 2008-09-26 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009126688A2 WO2009126688A2 (fr) | 2009-10-15 |
WO2009126688A3 WO2009126688A3 (fr) | 2009-12-10 |
WO2009126688A8 true WO2009126688A8 (fr) | 2010-06-03 |
Family
ID=40873503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/039868 WO2009126688A2 (fr) | 2008-04-09 | 2009-04-08 | Compositions et procédés nouveaux pour le traitement de maladies de nature immunitaire |
Country Status (18)
Country | Link |
---|---|
US (5) | US20090258013A1 (fr) |
EP (3) | EP3208612B1 (fr) |
JP (7) | JP5770624B2 (fr) |
KR (4) | KR101692080B1 (fr) |
CN (3) | CN102057272B (fr) |
AU (1) | AU2009233708B2 (fr) |
BR (1) | BRPI0906550B8 (fr) |
CA (3) | CA2719189C (fr) |
DK (1) | DK2279412T3 (fr) |
ES (2) | ES2640533T3 (fr) |
HK (1) | HK1211081A1 (fr) |
HU (1) | HUE036780T2 (fr) |
IL (5) | IL208285A0 (fr) |
MX (3) | MX364200B (fr) |
PL (2) | PL2279412T3 (fr) |
SG (2) | SG10201402815VA (fr) |
SI (1) | SI2279412T1 (fr) |
WO (1) | WO2009126688A2 (fr) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040121370A1 (en) | 2002-09-11 | 2004-06-24 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
CA2719189C (fr) | 2008-04-09 | 2020-08-04 | Genentech, Inc. | Compositions et procedes nouveaux pour le traitement de maladies de nature immunitaire |
HUE042192T2 (hu) | 2011-09-23 | 2019-06-28 | Oncomed Pharm Inc | VEGF/DLL4-kötõ ágensek és alkalmazásaik |
AR093788A1 (es) * | 2012-12-04 | 2015-06-24 | Oncomed Pharm Inc | Inmunoterapia con agentes de enlace |
PL3021869T3 (pl) | 2013-07-16 | 2020-11-16 | F. Hoffmann-La Roche Ag | Sposoby leczenia nowotworu z użyciem antagonistów wiązania osi PD-1 i inhibitorów TIGIT |
WO2015006811A2 (fr) * | 2013-07-19 | 2015-01-22 | The Walter And Eliza Hall Institute Of Medical Research | Méthodes de diagnostic |
AU2014308552B2 (en) * | 2013-08-22 | 2020-02-13 | The Council Of The Queensland Institute Of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
AU2013398294A1 (en) * | 2013-08-22 | 2016-03-17 | The Council Of The Queensland Institute Of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
US20160208000A1 (en) * | 2013-08-22 | 2016-07-21 | The Council Of The Queensland Institute Of Medical Research | Immunoreceptor modulation for treating cancer and viral infections |
CN103487572B (zh) * | 2013-10-08 | 2017-03-29 | 北京大学人民医院 | 滤泡辅助性T淋巴细胞(Tfh)在自身免疫性疾病病情预警中的应用 |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
EP3119913B1 (fr) * | 2014-03-21 | 2021-01-06 | The Brigham and Women's Hospital, Inc. | Procédés et compositions pour le traitement de maladies immunitaires ou de troubles et/ou la surveillance thérapeutique |
US9885021B2 (en) | 2014-06-12 | 2018-02-06 | Children's National Medical Center | Generation of broadly-specific, virus-immune cells targeting multiple HIV antigens for preventive and therapeutic use |
PE20170140A1 (es) * | 2014-07-16 | 2017-03-30 | Genentech Inc | Metodos para tratar el cancer con inhibidores de tigit y agentes contra el cancer |
TN2017000024A1 (en) * | 2014-08-19 | 2018-07-04 | Merck Sharp & Dohme | Anti-tigit antibodies. |
SG11201703376QA (en) * | 2014-11-06 | 2017-05-30 | Genentech Inc | Combination therapy comprising ox40 binding agonists and tigit inhibitors |
TN2017000267A1 (en) * | 2014-12-23 | 2018-10-19 | Bristol Myers Squibb Co | Antibodies to tigit |
MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
WO2016134335A2 (fr) | 2015-02-19 | 2016-08-25 | Compugen Ltd. | Polypeptides pvrig et méthodes de traitement |
HUE049032T2 (hu) | 2015-02-19 | 2020-08-28 | Compugen Ltd | PVRIG elleni antitestek és alkalmazási eljárások |
CN114773486A (zh) | 2015-04-17 | 2022-07-22 | 高山免疫科学股份有限公司 | 具有可调的亲和力的免疫调节蛋白 |
US11022615B2 (en) * | 2015-05-04 | 2021-06-01 | University Of Florida Research Foundation, Inc. | Regulatory T-cells, method for their isolation and uses |
TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit結合劑和彼之用途 |
HUE061253T2 (hu) | 2015-05-29 | 2023-06-28 | Bristol Myers Squibb Co | Antitestek OX40 ellen és azok felhasználásai |
JO3620B1 (ar) * | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
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