WO2011044501A3 - Analogues d'aminoglycoside antibactériens - Google Patents

Analogues d'aminoglycoside antibactériens Download PDF

Info

Publication number
WO2011044501A3
WO2011044501A3 PCT/US2010/052043 US2010052043W WO2011044501A3 WO 2011044501 A3 WO2011044501 A3 WO 2011044501A3 US 2010052043 W US2010052043 W US 2010052043W WO 2011044501 A3 WO2011044501 A3 WO 2011044501A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
antibacterial aminoglycoside
aminoglycoside analogs
disclosed
analogs
Prior art date
Application number
PCT/US2010/052043
Other languages
English (en)
Other versions
WO2011044501A2 (fr
WO2011044501A9 (fr
Inventor
James Bradley Aggen
Paola Dozzo
Adam Aaron Goldblum
Darin James Hildebrandt
Timothy Robert Kane
Micah James Gliedt
Martin Sheringham Linsell
Original Assignee
Achaogen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achaogen, Inc. filed Critical Achaogen, Inc.
Priority to CA2777107A priority Critical patent/CA2777107A1/fr
Priority to EP10766198A priority patent/EP2486044A2/fr
Priority to MX2012004036A priority patent/MX2012004036A/es
Priority to CN2010800507463A priority patent/CN102596981A/zh
Priority to JP2012533359A priority patent/JP2013507391A/ja
Publication of WO2011044501A2 publication Critical patent/WO2011044501A2/fr
Publication of WO2011044501A3 publication Critical patent/WO2011044501A3/fr
Priority to US13/441,696 priority patent/US8481502B2/en
Publication of WO2011044501A9 publication Critical patent/WO2011044501A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

L'invention concerne des composés antibactériens de structure (I), y compris leurs stéréoisomères, sels pharmaceutiquement acceptables et promédicaments, dans laquelle Q1, Q2, Q5, R1, R2, R3, Z1 et Z2 sont tels que définis dans le présent document. Des procédés associés avec la préparation et l'utilisation de tels composés, ainsi que des compositions pharmaceutiques comprenant de tels composés, sont également décrits.
PCT/US2010/052043 2009-10-09 2010-10-08 Analogues d'aminoglycoside antibactériens WO2011044501A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2777107A CA2777107A1 (fr) 2009-10-09 2010-10-08 Analogues d'aminoglycoside antibacteriens
EP10766198A EP2486044A2 (fr) 2009-10-09 2010-10-08 Analogues d'aminoglycoside antibactériens
MX2012004036A MX2012004036A (es) 2009-10-09 2010-10-08 Analogos de aminoglicosidos antibacterianos.
CN2010800507463A CN102596981A (zh) 2009-10-09 2010-10-08 抗菌氨基糖苷类类似物
JP2012533359A JP2013507391A (ja) 2009-10-09 2010-10-08 抗ウイルスアミノグリコシド類似体
US13/441,696 US8481502B2 (en) 2009-10-09 2012-04-06 Antibacterial aminoglycoside analogs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25011909P 2009-10-09 2009-10-09
US61/250,119 2009-10-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/441,696 Continuation US8481502B2 (en) 2009-10-09 2012-04-06 Antibacterial aminoglycoside analogs

Publications (3)

Publication Number Publication Date
WO2011044501A2 WO2011044501A2 (fr) 2011-04-14
WO2011044501A3 true WO2011044501A3 (fr) 2011-06-16
WO2011044501A9 WO2011044501A9 (fr) 2012-04-19

Family

ID=43513987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/052043 WO2011044501A2 (fr) 2009-10-09 2010-10-08 Analogues d'aminoglycoside antibactériens

Country Status (7)

Country Link
US (1) US8481502B2 (fr)
EP (1) EP2486044A2 (fr)
JP (1) JP2013507391A (fr)
CN (1) CN102596981A (fr)
CA (1) CA2777107A1 (fr)
MX (1) MX2012004036A (fr)
WO (1) WO2011044501A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1957507B1 (fr) 2005-12-02 2018-10-24 Ionis Pharmaceuticals, Inc. Analogues d'aminoglycoside 4,5-substitués antibactériens comportant plusieurs substituants
CN101868472B (zh) 2007-11-21 2013-05-29 尔察祯有限公司 抗菌性氨基糖苷类似物
WO2010030690A1 (fr) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Analogues d'aminoglycosides 4,6-substitués et modifiés aux positions 6',6" et 1 possédant une activité antibactérienne
WO2010030704A2 (fr) 2008-09-10 2010-03-18 Achaogen, Inc. Analogues d’aminoglycosides antibactériens
WO2010042851A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d’aminoglycoside antibactériens
WO2010042850A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010132765A2 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010132757A2 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010132759A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de la dibékacine
WO2010132768A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de sisomicine
WO2010132760A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de tobramycine
JP2013507391A (ja) 2009-10-09 2013-03-04 アカオジェン インコーポレイテッド 抗ウイルスアミノグリコシド類似体
WO2012067978A1 (fr) 2010-11-17 2012-05-24 Achaogen, Inc. Analogues d'aminoglycosides antibactériens
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) * 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
US10308597B2 (en) * 2014-04-30 2019-06-04 Rgenix, Inc. Inhibitors of creatine transport and uses thereof
US11414450B1 (en) 2017-08-28 2022-08-16 Revagenix, Inc. Aminoglycosides and uses thereof
US11673907B2 (en) 2018-04-03 2023-06-13 Revagenix, Inc. Modular synthesis of aminoglycosides
CN116063183B (zh) * 2023-01-28 2023-06-27 山东国邦药业有限公司 一种环丙胺的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3808198A (en) * 1972-09-07 1974-04-30 Bristol Myers Co Lividomycin b derivatives
US4247687A (en) * 1979-06-12 1981-01-27 Farmitalia Carlo Erba S.P.A. Aminoglycoside antibiotic derivatives and process for their preparation
DE3044970A1 (de) * 1980-01-30 1981-09-03 Farmitalia Carlo Erba S.p.A., 20159 Milano 3',4'-dideoxyparomomycin, verfahren zu dessen herstellung und diese verbindung enthaltende arzneimittel
WO2007064954A2 (fr) * 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Analogues d'aminoglycoside 4,5-substitués antibactériens comportant plusieurs substituants
WO2008124821A1 (fr) * 2007-04-10 2008-10-16 Achaogen Inc. Analogues de l'aminoglycoside 1,4,5-substitué antibactérien

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1361393A (fr) 1963-03-29 1964-05-22 Rit Rech Ind Therapeut Dérivés d'antibiotiques basiques et leur procédé de préparation
US3897412A (en) 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
JPS5632999B2 (fr) 1972-05-04 1981-07-31
US3896106A (en) 1972-06-26 1975-07-22 Bristol Myers Co Antibiotic derivatives
FR2209546B1 (fr) 1972-12-06 1977-09-02 Bristol Myers Co
US3860574A (en) 1972-12-06 1975-01-14 Bristol Myers Co Derivatives of neomycin b and neomycin c
JPS5652035B2 (fr) 1973-02-06 1981-12-09
JPS553358B2 (fr) 1973-03-13 1980-01-24
US4170642A (en) 1973-10-01 1979-10-09 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Derivatives of kanamycin A
GB1454489A (en) 1974-04-11 1976-11-03 Farmaceutici Italia Paromomycin derivatives
DE2515630C2 (de) 1974-05-28 1982-11-18 Società Farmaceutici Italia S.p.A., 20146 Milano 4-0-(6-Amino-6-desoxy-alpha-D-glucopyranosyl)-5-0[3-0(2,6-diamino-2,6-didesoxy-ß-L-idophyranosyl)-ß-D-ribofuranosyl]-2-desoxy-streptamin, Verfahren zu seiner Herstellung und diese Verbindung enthaltende Arzneimittel
JPS5850235B2 (ja) 1974-12-11 1983-11-09 明治製菓株式会社 ３′，４′−α−エポキシ−リボスタマイシン又は−カナマイシンＢの製造法
JPS6055520B2 (ja) 1976-02-17 1985-12-05 興和株式会社 リビドマイシンｂ誘導体の製法
US4066753A (en) 1976-05-27 1978-01-03 Canadian Patents And Development Limited Neomycin and paromomycin derivatives
US4424343A (en) 1977-04-28 1984-01-03 Bristol Myers Company Preparation of 1-N- ω-amino-α-hydroxyalkanoyl!kanamycin polysilylates and products
US4347354A (en) 1977-04-28 1982-08-31 Bristol-Myers Company Preparation of 1-N-[ω-amino-α-hydroxyalkanoyl]aminoglycoside polysilylated antibiotics and products obtained therefrom
CA1271744C (fr) 1978-02-21 1990-07-17 Prepartion d'aminoglycosides
CY1242A (en) 1978-04-26 1984-06-29 Bristol Myers Co Process for the preparation of 1-n-acylaminoglycosides
JPS5515445A (en) 1978-07-21 1980-02-02 Kyowa Hakko Kogyo Co Ltd Introduction of amino-protecting group by microorganism
DE2936120A1 (de) 1978-09-14 1980-03-27 Sandoz Ag Neue aminoglykoside, deren herstellung und deren verwendung als antimikrobielle mittel
ZA803031B (en) 1979-06-07 1981-05-27 Erba Farmitalia Paromomycin derivatives
GB2068366B (en) 1980-01-30 1983-06-02 Erba Farmitalia Paromycin derivative
WO1982000464A1 (fr) 1980-07-28 1982-02-18 Loibner H Aminoglycosides guanyles, leur procede de preparation et leur utilisation comme produits pharmaceutiques
DE3206725A1 (de) 1981-05-13 1982-12-02 Merck Patent Gmbh, 6100 Darmstadt Schwer loesliche salze von aminoglykosidantibiotika
DE3405326A1 (de) 1984-02-15 1985-08-22 Sandoz-Patent-GmbH, 7850 Lörrach Neue aminglykoside, verfahren zu ihrer herstellung und ihre verwendung
DE3431534A1 (de) 1984-08-28 1986-03-13 Merck Patent Gmbh, 6100 Darmstadt Flavanonderivate
IT1225484B (it) 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
US5470836A (en) 1988-04-29 1995-11-28 Farmitalia Carlo Erba S.R.L. Paromomycin or its derivatives or salts thereof in combination with sodium stirogluconate for parenteral treatment of human parasitic diseases
AU640511B2 (en) 1990-07-30 1993-08-26 Pharmacia & Upjohn Company Hexa-n-(o-hydroxybenzyl) neomycin b for inhibiting human retroviruses and for the treatment of aids
US5534408A (en) 1993-09-24 1996-07-09 University Of Massachusetts Medical Center 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
WO1994009792A1 (fr) 1992-10-23 1994-05-11 University Of Massachusetts Medical Center Inhibition de la fixation arn/ligand au moyen de petites molecules
US5942547A (en) 1995-09-08 1999-08-24 Scriptgen Pharmaceuticals, Inc. 2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and therapeutic methods using same
IL127773A0 (en) 1998-12-28 1999-10-28 Yeda Res & Dev Saccharide conjugates and pharmaceutical compositions comprising them
US6541456B1 (en) 1999-12-01 2003-04-01 Isis Pharmaceuticals, Inc. Antimicrobial 2-deoxystreptamine compounds
IT1317735B1 (it) 2000-01-26 2003-07-15 Nicox Sa Sali di agenti antimicrobici.
EP1219306A1 (fr) 2000-12-29 2002-07-03 Nicox S.A. Compositions contenant des cyclodextrines et des médicaments libérant le NO
CN1156488C (zh) * 2001-12-18 2004-07-07 国家药品监督管理局四川抗菌素工业研究所 小诺霉素新衍生物、制备方法和医药用途
US20050085432A1 (en) 2001-12-26 2005-04-21 Aviva Lapidot Methods of using conjugates of saccharides and acetamidino or guanidino compounds for treating bacterial infections
WO2003101405A2 (fr) 2002-03-14 2003-12-11 President And Fellows Of Harvard College Antibiotiques a base d'amino-glycosides et procedes d'utilisation correspondants
US7037936B2 (en) 2002-06-17 2006-05-02 Signal Pharmaceuticals, Llc. Compounds useful for the treatment of cancer, compositions thereof and methods therewith
US7160992B2 (en) 2003-04-28 2007-01-09 Yeda Research And Development Co., Ltd. Amino-modified polysaccharides and methods of generating and using same
US20050004052A1 (en) 2003-07-03 2005-01-06 Technion Research & Development Foundation Ltd. Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes
US7635685B2 (en) 2003-07-03 2009-12-22 Technion Research & Development Foundation Ltd. Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes and for inhibition of anthrax lethal factor
US20050143328A1 (en) 2003-10-31 2005-06-30 Steele Philip M. Composition and treatment for envelope virus infections
EP1809645A1 (fr) 2004-11-05 2007-07-25 Isis Pharmaceuticals, Inc. Composes antimicrobiens de 2-desoxystreptamine
WO2007028012A2 (fr) 2005-09-01 2007-03-08 Isis Pharmaceuticals, Inc. Analogues d'aminoglycosides 4,5-substitues 6'-modifies antibacteriens
PE20071025A1 (es) 2006-01-31 2007-10-17 Mitsubishi Tanabe Pharma Corp Compuesto amina trisustituido
EP2044056B1 (fr) 2006-07-14 2012-08-22 Novartis AG Dérivés de la pyrimidine en tant qu'inhibiteurs d'alk-5
EP1953171A1 (fr) 2007-02-02 2008-08-06 Eidgenössische Technische Hochschule Zürich Antibiotiques aminoglycosides ciblant ARN ribosomaux bacteriens 16S
JP4992044B2 (ja) 2007-08-30 2012-08-08 Ｊｆｅスチール株式会社 クロメートフリー被覆溶融亜鉛めっき鋼板およびその製造方法
CN101868472B (zh) 2007-11-21 2013-05-29 尔察祯有限公司 抗菌性氨基糖苷类似物
WO2010030704A2 (fr) 2008-09-10 2010-03-18 Achaogen, Inc. Analogues d’aminoglycosides antibactériens
WO2010030690A1 (fr) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Analogues d'aminoglycosides 4,6-substitués et modifiés aux positions 6',6" et 1 possédant une activité antibactérienne
WO2010042850A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010042851A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d’aminoglycoside antibactériens
TW201100091A (en) 2009-05-14 2011-01-01 Achaogen Inc Aminoglycoside dosing regimens
WO2010132770A1 (fr) 2009-05-14 2010-11-18 Achaogen, Inc. Traitement des infections klebsiella pneumoniae avec des composés aminoglycoside antibactériens
WO2010132777A2 (fr) 2009-05-14 2010-11-18 Achaogen, Inc. Traitement des infections des voies urinaires avec des composés aminoglycoside antibactériens
WO2010132768A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de sisomicine
WO2010132757A2 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010132759A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de la dibékacine
WO2010132765A2 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010132760A1 (fr) 2009-05-15 2010-11-18 Achaogen, Inc. Dérivés antibactériens de tobramycine
WO2010147836A1 (fr) 2009-06-17 2010-12-23 Achaogen, Inc. Therapie de combinaison mettant en œuvre des composes d'aminoglycoside antibacteriens
WO2011044502A1 (fr) 2009-10-09 2011-04-14 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2011044538A1 (fr) 2009-10-09 2011-04-14 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
JP2013507391A (ja) 2009-10-09 2013-03-04 アカオジェン インコーポレイテッド 抗ウイルスアミノグリコシド類似体
WO2011044503A1 (fr) 2009-10-09 2011-04-14 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2011044498A1 (fr) 2009-10-09 2011-04-14 Achaogen, Inc. Analogues antibactériens d'aminoglycosides
WO2012067978A1 (fr) 2010-11-17 2012-05-24 Achaogen, Inc. Analogues d'aminoglycosides antibactériens

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3808198A (en) * 1972-09-07 1974-04-30 Bristol Myers Co Lividomycin b derivatives
US4247687A (en) * 1979-06-12 1981-01-27 Farmitalia Carlo Erba S.P.A. Aminoglycoside antibiotic derivatives and process for their preparation
DE3044970A1 (de) * 1980-01-30 1981-09-03 Farmitalia Carlo Erba S.p.A., 20159 Milano 3',4'-dideoxyparomomycin, verfahren zu dessen herstellung und diese verbindung enthaltende arzneimittel
WO2007064954A2 (fr) * 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Analogues d'aminoglycoside 4,5-substitués antibactériens comportant plusieurs substituants
WO2008124821A1 (fr) * 2007-04-10 2008-10-16 Achaogen Inc. Analogues de l'aminoglycoside 1,4,5-substitué antibactérien

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HANESSIAN, S. ET AL.: "Probing the ribosomal RNA A-site with functionally diverse analogues of paromomycin - synthesis of ring I mimetics", TETRAHEDRON, vol. 63, 2007, pages 827 - 846, XP002621093 *

Also Published As

Publication number Publication date
JP2013507391A (ja) 2013-03-04
WO2011044501A2 (fr) 2011-04-14
EP2486044A2 (fr) 2012-08-15
US20120258925A1 (en) 2012-10-11
CN102596981A (zh) 2012-07-18
MX2012004036A (es) 2012-06-27
US8481502B2 (en) 2013-07-09
WO2011044501A9 (fr) 2012-04-19
CA2777107A1 (fr) 2011-04-14

Similar Documents

Publication Publication Date Title
WO2011044501A3 (fr) Analogues d'aminoglycoside antibactériens
WO2010030704A3 (fr) Analogues d’aminoglycosides antibactériens
WO2010132757A3 (fr) Analogues d'aminoglycoside antibactériens
WO2010132765A3 (fr) Analogues d'aminoglycoside antibactériens
MX2010005632A (es) Analogos de aminoglucosidos antibacterianos.
WO2012054110A3 (fr) Composés et procédés permettant d'inhiber le transport du phosphate
WO2008154642A3 (fr) Agents antibactériens
WO2014151871A3 (fr) Inhibiteurs de jak2 et alk2 et leurs procédés d'utilisation
WO2012024584A3 (fr) Composés oxystérol
WO2007135527A3 (fr) Composés de benzimidazolyle
WO2011012816A3 (fr) Formulation pharmaceutique
WO2012024581A3 (fr) Composés oxystérol
WO2012006474A3 (fr) Composés et procédés pour l'inhibition du transport de phosphate
WO2004062601A3 (fr) Agents antibacteriens
WO2007138110A3 (fr) Composés interagissant avec des canaux ioniques, notamment des canaux ioniques de la famille kv
EP2590655A4 (fr) Composés et procédés pour l'inhibition du transport de phosphate
EP3216798A3 (fr) Composés kétolides
WO2008143649A3 (fr) Nouveaux composés oxazolidinones comme agents anti-infectieux
WO2008129501A3 (fr) Compositions pharmaceutiques de duloxetine
WO2014102592A3 (fr) Composés de pipéridine de type quinoxaline substituée par oxime et leurs utilisations
WO2014062838A3 (fr) Modulateurs de pkm2 et procédés pour les utiliser
WO2009038412A3 (fr) Composés inhibiteurs de la béta-sécrétase
AU2010321366A8 (en) Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
WO2012024583A3 (fr) Composés oxystérol
WO2011135580A3 (fr) Compositions pharmaceutiques de sirolimus

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080050746.3

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10766198

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: MX/A/2012/004036

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2777107

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2012533359

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2010766198

Country of ref document: EP