WO2009044895A1 - 標的遺伝子の発現を抑制する組成物 - Google Patents
標的遺伝子の発現を抑制する組成物 Download PDFInfo
- Publication number
- WO2009044895A1 WO2009044895A1 PCT/JP2008/068104 JP2008068104W WO2009044895A1 WO 2009044895 A1 WO2009044895 A1 WO 2009044895A1 JP 2008068104 W JP2008068104 W JP 2008068104W WO 2009044895 A1 WO2009044895 A1 WO 2009044895A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microrna
- expression
- target gene
- composition
- lipid membrane
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
本発明は、標的遺伝子の発現を抑制する作用を有し、マイクロRNAまたはその誘導体等を含有する組成物等を提供することを目的とし、リード粒子とマイクロRNAまたは人工マイクロRNA等を構成成分とする複合粒子および該複合粒子を被覆する脂質二重膜から構成され、該脂質二重膜の構成成分が特定の極性有機溶媒に可溶であり、該脂質二重膜の構成成分および該複合粒子が、特定の濃度で該極性有機溶媒を含む液に分散可能である、該マイクロRNAまたは人工マイクロRNA等を封入したリポソームを含有する組成物等を提供する。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-260402 | 2007-10-03 | ||
JP2007260402 | 2007-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009044895A1 true WO2009044895A1 (ja) | 2009-04-09 |
Family
ID=40526310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/068104 WO2009044895A1 (ja) | 2007-10-03 | 2008-10-03 | 標的遺伝子の発現を抑制する組成物 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009044895A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010110314A1 (ja) * | 2009-03-27 | 2010-09-30 | 協和発酵キリン株式会社 | 核酸を含有する肺高血圧症治療剤 |
WO2011111715A1 (ja) * | 2010-03-09 | 2011-09-15 | 協和発酵キリン株式会社 | 細胞周期を制御する核酸 |
US8513209B2 (en) | 2007-11-09 | 2013-08-20 | The Board Of Regents, The University Of Texas System | Micro-RNAS of the MIR-15 family modulate cardiomyocyte survival and cardiac repair |
CN103861121A (zh) * | 2012-12-10 | 2014-06-18 | 中国医学科学院基础医学研究所 | 微小RNA分子miR491-5p在胰腺癌的治疗和/或诊断和/或预后中的用途 |
US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006137941A2 (en) * | 2004-11-12 | 2006-12-28 | Ambion, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
-
2008
- 2008-10-03 WO PCT/JP2008/068104 patent/WO2009044895A1/ja active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006137941A2 (en) * | 2004-11-12 | 2006-12-28 | Ambion, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
Non-Patent Citations (1)
Title |
---|
LAI, E. C.: "miRNAs: Whys and Wherefores of miRNA-Mediated Regulation", CURRENT BIOLOGY, vol. 15, no. 12, 2005, pages R458 - R460 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8513209B2 (en) | 2007-11-09 | 2013-08-20 | The Board Of Regents, The University Of Texas System | Micro-RNAS of the MIR-15 family modulate cardiomyocyte survival and cardiac repair |
US9078919B2 (en) | 2007-11-09 | 2015-07-14 | The Board Of Regents, The University Of Texas System | Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair |
WO2010110314A1 (ja) * | 2009-03-27 | 2010-09-30 | 協和発酵キリン株式会社 | 核酸を含有する肺高血圧症治療剤 |
WO2011111715A1 (ja) * | 2010-03-09 | 2011-09-15 | 協和発酵キリン株式会社 | 細胞周期を制御する核酸 |
US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
CN103861121A (zh) * | 2012-12-10 | 2014-06-18 | 中国医学科学院基础医学研究所 | 微小RNA分子miR491-5p在胰腺癌的治疗和/或诊断和/或预后中的用途 |
CN103861121B (zh) * | 2012-12-10 | 2016-02-24 | 中国医学科学院基础医学研究所 | 微小RNA分子miR491-5p在胰腺癌的治疗和/或诊断和/或预后中的用途 |
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