WO2009031627A1 - パラテルフェニル化合物、その薬理学的に許容される塩、その製造方法及び用途 - Google Patents

パラテルフェニル化合物、その薬理学的に許容される塩、その製造方法及び用途 Download PDF

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Publication number
WO2009031627A1
WO2009031627A1 PCT/JP2008/065999 JP2008065999W WO2009031627A1 WO 2009031627 A1 WO2009031627 A1 WO 2009031627A1 JP 2008065999 W JP2008065999 W JP 2008065999W WO 2009031627 A1 WO2009031627 A1 WO 2009031627A1
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WO
WIPO (PCT)
Prior art keywords
para
acceptable salt
pharmacologically acceptable
same
compound
Prior art date
Application number
PCT/JP2008/065999
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English (en)
French (fr)
Inventor
Hiroyuki Koshino
Syunya Takahashi
Naoki Abe
Junichi Onose
Original Assignee
Riken
Tokyo University Of Agriculture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Riken, Tokyo University Of Agriculture filed Critical Riken
Priority to JP2009531283A priority Critical patent/JP5408660B2/ja
Publication of WO2009031627A1 publication Critical patent/WO2009031627A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明は、式（１）で示されるパラテルフェニル化合物又はその薬理学的に許容される塩及びその製造方法及び用途を提供する。 （式中、Ｒ１及びＲ２は、それぞれ独立に、炭素数１～６のアルキル基、環状アルキル基、アルコキシアルキル基、シロキシアルキル基、フェニル基又は炭素数３又は４のアルキレン基を表し、Ｒ３及びＲ４は、それぞれ独立に、水素又は水酸基の保護基を表す。） 　本発明によれば、化学合成により、腫瘍壊死因子（ＴＮＦ）－α産生阻害活性を有する化合物を提供することができる。前記化合物は有害な作用もなく、自己免疫疾患、アレルギー疾患等の治療剤として有用である。
PCT/JP2008/065999 2007-09-04 2008-09-04 パラテルフェニル化合物、その薬理学的に許容される塩、その製造方法及び用途 WO2009031627A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009531283A JP5408660B2 (ja) 2007-09-04 2008-09-04 パラテルフェニル化合物、その薬理学的に許容される塩、その製造方法及び用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007229029 2007-09-04
JP2007-229029 2007-09-04

Publications (1)

Publication Number Publication Date
WO2009031627A1 true WO2009031627A1 (ja) 2009-03-12

Family

ID=40428940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065999 WO2009031627A1 (ja) 2007-09-04 2008-09-04 パラテルフェニル化合物、その薬理学的に許容される塩、その製造方法及び用途

Country Status (2)

Country Link
JP (1) JP5408660B2 (ja)
WO (1) WO2009031627A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012094788A1 (zh) * 2011-01-13 2012-07-19 山东大学 对三联苯衍生物及其在制备抗肿瘤药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070251A (ja) * 2005-09-05 2007-03-22 Tokyo Univ Of Agriculture 抗酸化活性及び抗アレルギー活性を有する化合物並びに該化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU729320B2 (en) * 1996-07-31 2001-02-01 Shionogi & Co., Ltd. Novel para-terphenyl compounds
RU2230551C2 (ru) * 1999-07-23 2004-06-20 ШИОНОГИ энд КО, ЛТД. Ингибиторы th2-дифференцировки
EP1359139A1 (en) * 2001-01-18 2003-11-05 Shionogi & Co., Ltd. Terphenyl compounds bearing substituted amino groups
JP2008001675A (ja) * 2006-06-26 2008-01-10 Daiei Probis Kk 抗アレルギー剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070251A (ja) * 2005-09-05 2007-03-22 Tokyo Univ Of Agriculture 抗酸化活性及び抗アレルギー活性を有する化合物並びに該化合物の製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHUN XIE ET AL: "Vialinin B, a novel potent inhibitor of TNF-α production, isolated from an edible mushroom, Thelephora vialis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 20, 2006, pages 5424 - 5426, XP025107186 *
YE YUE QI ET AL: "First Total Synthesis of Vialinin A, a Novel and Extremely Potent Inhibitor of TNF-α Production", ORGANIC LETTERS, vol. 9, no. 21, 2007, pages 4131 - 4134, XP002552523 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012094788A1 (zh) * 2011-01-13 2012-07-19 山东大学 对三联苯衍生物及其在制备抗肿瘤药物中的应用

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Publication number Publication date
JP5408660B2 (ja) 2014-02-05
JPWO2009031627A1 (ja) 2010-12-16

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