WO2009022670A1 - Comprime se desintegrant rapidement - Google Patents
Comprime se desintegrant rapidement Download PDFInfo
- Publication number
- WO2009022670A1 WO2009022670A1 PCT/JP2008/064367 JP2008064367W WO2009022670A1 WO 2009022670 A1 WO2009022670 A1 WO 2009022670A1 JP 2008064367 W JP2008064367 W JP 2008064367W WO 2009022670 A1 WO2009022670 A1 WO 2009022670A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tablet
- disintegrating tablet
- acid
- water
- enteric coated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Abstract
L'invention porte sur un comprimé qui comprend une substance physiologiquement active non stable en milieu acide en tant que qu'ingrédient actif, qui a le même niveau de dureté que celui d'un comprimé classique, et qui peut présenter une excellente propriété de désintégration rapide même en présence d'une faible quantité d'eau. L'invention porte spécifiquement sur un comprimé qui peut être mis en suspension dans de l'eau lors de son utilisation. Le comprimé comprend un granulé fin à enrobage entérique comprenant une substance physiologiquement active instable au milieu acide et un aditif, le granulé fin à enrobage entérique étant contenu dans une quantité d'environ 10 à 38 % en poids pour un comprimé.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007209578 | 2007-08-10 | ||
JP2007-209578 | 2007-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009022670A1 true WO2009022670A1 (fr) | 2009-02-19 |
Family
ID=40350724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/064367 WO2009022670A1 (fr) | 2007-08-10 | 2008-08-08 | Comprime se desintegrant rapidement |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009022670A1 (fr) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2210591A2 (fr) | 2009-01-26 | 2010-07-28 | Shin-Etsu Chemical Co., Ltd. | Procédé de fabrication de comprimés à granulation par voie humide utilisant une dispersion aqueuse de cellulose hydroxypropyl substituée faible |
JP2014040379A (ja) * | 2012-08-21 | 2014-03-06 | Shin Etsu Chem Co Ltd | 疎水性薬物を含む錠剤製造方法 |
CN104271339A (zh) * | 2012-05-01 | 2015-01-07 | 麦克内尔-Ppc股份有限公司 | 制造固体剂型的方法 |
WO2015105992A1 (fr) * | 2014-01-10 | 2015-07-16 | Mcneil-Ppc, Inc. | Procédé pour fabriquer un comprimé par radiofréquence et particules revêtues à perte |
US9107807B2 (en) | 2009-09-24 | 2015-08-18 | Mcneil-Ppc, Inc. | Machine for the manufacture of dosage forms utilizing radiofrequency energy |
US9233491B2 (en) | 2012-05-01 | 2016-01-12 | Johnson & Johnson Consumer Inc. | Machine for production of solid dosage forms |
JP6002870B1 (ja) * | 2015-10-16 | 2016-10-05 | 持田製薬株式会社 | 低用量薬物を含有する口腔内崩壊錠 |
US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
JP2018536707A (ja) * | 2015-10-30 | 2018-12-13 | キャンサー プリベンション ファーマシューティカルズ,インコーポレイテッド | エフロルニチンとスリンダクの固定用量複合製剤 |
US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
US10835488B2 (en) | 2016-06-16 | 2020-11-17 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
US11077055B2 (en) | 2015-04-29 | 2021-08-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61221116A (ja) * | 1985-03-25 | 1986-10-01 | アボツト ラボラトリーズ | 錠剤の組成物 |
JPS63198625A (ja) * | 1986-12-12 | 1988-08-17 | ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド | アズモレン剤形 |
JPS63301816A (ja) * | 1987-01-29 | 1988-12-08 | Takeda Chem Ind Ltd | 有核顆粒およびその製造法 |
JPH02174931A (ja) * | 1988-09-27 | 1990-07-06 | Takeda Chem Ind Ltd | 有核顆粒およびその製造法 |
JPH0971523A (ja) * | 1995-09-07 | 1997-03-18 | Riyuukakusan:Kk | 口腔内で崩壊性の速い錠剤 |
WO1998002185A1 (fr) * | 1996-07-12 | 1998-01-22 | Daiichi Pharmaceutical Co., Ltd. | Materiaux moules par compression, a desagregation rapide, et leur procede de production |
JPH1143429A (ja) * | 1997-05-27 | 1999-02-16 | Takeda Chem Ind Ltd | 固形製剤 |
JP2000103731A (ja) * | 1998-07-28 | 2000-04-11 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
-
2008
- 2008-08-08 WO PCT/JP2008/064367 patent/WO2009022670A1/fr active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61221116A (ja) * | 1985-03-25 | 1986-10-01 | アボツト ラボラトリーズ | 錠剤の組成物 |
JPS63198625A (ja) * | 1986-12-12 | 1988-08-17 | ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド | アズモレン剤形 |
JPS63301816A (ja) * | 1987-01-29 | 1988-12-08 | Takeda Chem Ind Ltd | 有核顆粒およびその製造法 |
JPH02174931A (ja) * | 1988-09-27 | 1990-07-06 | Takeda Chem Ind Ltd | 有核顆粒およびその製造法 |
JPH0971523A (ja) * | 1995-09-07 | 1997-03-18 | Riyuukakusan:Kk | 口腔内で崩壊性の速い錠剤 |
WO1998002185A1 (fr) * | 1996-07-12 | 1998-01-22 | Daiichi Pharmaceutical Co., Ltd. | Materiaux moules par compression, a desagregation rapide, et leur procede de production |
JPH1143429A (ja) * | 1997-05-27 | 1999-02-16 | Takeda Chem Ind Ltd | 固形製剤 |
JP2000103731A (ja) * | 1998-07-28 | 2000-04-11 | Takeda Chem Ind Ltd | 速崩壊性固形製剤 |
Non-Patent Citations (1)
Title |
---|
HOSHI N. ET AL.: "Hydroxypropylcellulouse no Ko", IYAKUHIN TENKAZAI YORAN, JIHO INC., 1992, pages 26 - 27 * |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010189384A (ja) * | 2009-01-26 | 2010-09-02 | Shin-Etsu Chemical Co Ltd | 低置換度ヒドロキシプロピルセルロース水分散液を用いた湿式造粒打錠法 |
EP2210591A3 (fr) * | 2009-01-26 | 2011-01-19 | Shin-Etsu Chemical Co., Ltd. | Procédé de fabrication de comprimés à granulation par voie humide utilisant une dispersion aqueuse de cellulose hydroxypropyl substituée faible |
US8303868B2 (en) | 2009-01-26 | 2012-11-06 | Shin-Etsu Chemical Co., Ltd. | Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose |
JP2014133766A (ja) * | 2009-01-26 | 2014-07-24 | Shin Etsu Chem Co Ltd | 低置換度ヒドロキシプロピルセルロース水分散液を用いた湿式造粒打錠法 |
EP2210591A2 (fr) | 2009-01-26 | 2010-07-28 | Shin-Etsu Chemical Co., Ltd. | Procédé de fabrication de comprimés à granulation par voie humide utilisant une dispersion aqueuse de cellulose hydroxypropyl substituée faible |
US9107807B2 (en) | 2009-09-24 | 2015-08-18 | Mcneil-Ppc, Inc. | Machine for the manufacture of dosage forms utilizing radiofrequency energy |
US9610224B2 (en) | 2009-09-24 | 2017-04-04 | Johnson & Johnson Consumer Inc. | Manufacture of tablet in a die utilizing powder blend containing water-containing material |
US9445971B2 (en) | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
US9233491B2 (en) | 2012-05-01 | 2016-01-12 | Johnson & Johnson Consumer Inc. | Machine for production of solid dosage forms |
CN104271339A (zh) * | 2012-05-01 | 2015-01-07 | 麦克内尔-Ppc股份有限公司 | 制造固体剂型的方法 |
US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
JP2014040379A (ja) * | 2012-08-21 | 2014-03-06 | Shin Etsu Chem Co Ltd | 疎水性薬物を含む錠剤製造方法 |
US9789066B2 (en) | 2014-01-10 | 2017-10-17 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
WO2015105992A1 (fr) * | 2014-01-10 | 2015-07-16 | Mcneil-Ppc, Inc. | Procédé pour fabriquer un comprimé par radiofréquence et particules revêtues à perte |
JP2017502060A (ja) * | 2014-01-10 | 2017-01-19 | ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド | 高周波及び損失性被覆粒子を使用した錠剤の製造プロセス |
US11077055B2 (en) | 2015-04-29 | 2021-08-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
JP6002870B1 (ja) * | 2015-10-16 | 2016-10-05 | 持田製薬株式会社 | 低用量薬物を含有する口腔内崩壊錠 |
WO2017064815A1 (fr) * | 2015-10-16 | 2017-04-20 | 持田製薬株式会社 | Comprimé à désintégration buccale contenant un médicament à faible dose |
JP2018536707A (ja) * | 2015-10-30 | 2018-12-13 | キャンサー プリベンション ファーマシューティカルズ,インコーポレイテッド | エフロルニチンとスリンダクの固定用量複合製剤 |
US11529326B2 (en) | 2015-10-30 | 2022-12-20 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
US11925613B2 (en) | 2015-10-30 | 2024-03-12 | Cancer Prevention Pharmaceuticals, Inc. | Eflornithine and sulindac, fixed dose combination formulation |
US10835488B2 (en) | 2016-06-16 | 2020-11-17 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009022670A1 (fr) | Comprime se desintegrant rapidement | |
WO2007024949A3 (fr) | Agonistes d'alpha 2c adrenorecepteur | |
WO2009100441A3 (fr) | Formulations retard depot formulations | |
WO2009074735A8 (fr) | Utilisation d'un nouvel agent naturel dans des compositions cosmetiques | |
SG170764A1 (en) | Cream composition | |
WO2010001169A3 (fr) | Composés chimiques 251 | |
GEP20156376B (en) | Solid herbicide compositions with built-in adjuvant | |
TW200640501A (en) | Crush resistant delayed-release dosage forms | |
PL1791532T3 (pl) | Kompozycja w mikropeletkach o kontrolowanym uwalnianiu substancji fizjologicznie czynnych, sposób jej wytwarzania i jej zastosowanie w dziedzinie zootechniki | |
WO2009007328A3 (fr) | Utilisation d'homo- et de copolymères pour la stabilisation de formulations de substances actives | |
MX2009000035A (es) | Formulaciones de agente activo, procedimientos de preparacion y procedimientos de uso. | |
WO2009091576A3 (fr) | Préparations parentérales d'agonistes de dopamine | |
WO2008006514A8 (fr) | Combinaisons de principes actifs ayant des propriétés insecticides et acaricides | |
GB2443793B (en) | Product, method of manufacture and use | |
GEP20146087B (en) | Paediatric solution comprising beta-blocker | |
WO2007038627A3 (fr) | Compositions antimicrobiennes stabilisees et methodes de preparation associees | |
WO2008057300A3 (fr) | Antagonistes de trpvi et leurs utilisations | |
ZA200902118B (en) | Improvement of the biological action of agrochemical compositions when applied to the cultivation substrate, suitable formulations and use thereof | |
WO2004052294A3 (fr) | Compositions et methodes associees aux formulations de lipide:emodine | |
WO2007064557A3 (fr) | Compositions biocides solides et procedes d’utilisation de celles-ci | |
EP2801358A3 (fr) | Utilisation de la nicotine pour diminuer la douleur dans la région rénale chez l'homme | |
WO2008092219A3 (fr) | Composition pharmaceutique comprenant du tramadol et du cétoprofène en association | |
WO2011087705A3 (fr) | Croscarmellose à particules fines et utilisations associées | |
IL185096A0 (en) | Polymer compositions and their use in the production of active or effective ingredient compositions | |
PL2007347T3 (pl) | Kompozycja obejmująca środek do stabilizowania substancji czynnych w wodzie do picia i mieszankę musującą, sposób jej wytwarzania i jej zastosowanie |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08792351 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 08792351 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: JP |