WO2008111538A1 - Magnetic-sensitive material, magnetic-sensitive medicinal agent, and those production methods - Google Patents

Magnetic-sensitive material, magnetic-sensitive medicinal agent, and those production methods Download PDF

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Publication number
WO2008111538A1
WO2008111538A1 PCT/JP2008/054217 JP2008054217W WO2008111538A1 WO 2008111538 A1 WO2008111538 A1 WO 2008111538A1 JP 2008054217 W JP2008054217 W JP 2008054217W WO 2008111538 A1 WO2008111538 A1 WO 2008111538A1
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic
cross
sensitive
microparticle
medicinal agent
Prior art date
Application number
PCT/JP2008/054217
Other languages
French (fr)
Japanese (ja)
Inventor
Kazufumi Ogawa
Yoshiaki Watanabe
Original Assignee
Kazufumi Ogawa
Yoshiaki Watanabe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kazufumi Ogawa, Yoshiaki Watanabe filed Critical Kazufumi Ogawa
Publication of WO2008111538A1 publication Critical patent/WO2008111538A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Immunology (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed are: a magnetic-sensitive material in which a functional substance contained therein can be separated from a mixture readily by using a magnet; a magnetic-sensitive medicinal agent comprising a magnetic microparticle, an organic thin film covalently bound to the surface of the microparticle, and a medicinal agent bound and immobilized on the microparticle through the organic thin film, in which the pharmacokinetics of a medicinal agent contained therein can be controlled by using a magnet; and a process for producing each of the magnetic-sensitive material and the magnetic-sensitive medicinal agent. Specifically disclosed is a magnetic-sensitive material (10) which comprises: a magnetic microparticle (1); a thin film (4) formed by a film-like compound having a second functional group, which covers the magnetic microparticle (1); a cross-linking agent (5) having a first cross-linking group and a second cross-linking group, wherein the first cross-linking group can react with the second functional group to form a covalent bond, the second cross-linking group can react with a functional group in a functional substance (6) to form a bond, and the cross-linking agent (5) is bound to the surface of the thin film (4) via a covalent bond formed by the reaction between the second functional group and the first cross-linking group; and the functional substance (6) which is bound to the microparticle (1) via a bond formed by the reaction between the functional group in the functional substance (6) and the second cross-linking group.
PCT/JP2008/054217 2007-03-09 2008-03-07 Magnetic-sensitive material, magnetic-sensitive medicinal agent, and those production methods WO2008111538A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-060317 2007-03-09
JP2007060317A JP5391387B2 (en) 2007-03-09 2007-03-09 Magnetosensitive drug and method for producing the same

Publications (1)

Publication Number Publication Date
WO2008111538A1 true WO2008111538A1 (en) 2008-09-18

Family

ID=39759476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054217 WO2008111538A1 (en) 2007-03-09 2008-03-07 Magnetic-sensitive material, magnetic-sensitive medicinal agent, and those production methods

Country Status (2)

Country Link
JP (1) JP5391387B2 (en)
WO (1) WO2008111538A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62226817A (en) * 1986-03-18 1987-10-05 イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− Coated chromium dioxide particle
JPH08505625A (en) * 1993-01-11 1996-06-18 ダナ−ファーバー キャンサー インスティチュート Induction of cytotoxic T lymphocyte response
JP2001511820A (en) * 1997-11-25 2001-08-14 デイド、ベーリング、インコーポレイテッド Cyclosporin derivatives and uses thereof
WO2004087765A1 (en) * 2003-03-31 2004-10-14 Toto Ltd. Titanium dioxide complex having molecule distinguishability
WO2006025627A1 (en) * 2004-09-03 2006-03-09 Yonsei University Water-soluble nanoparticles stabilized with multi-functional group ligands and method of preapation thereof
JP2007269770A (en) * 2006-03-09 2007-10-18 Mitsubishi Chemicals Corp Functional magnetic super-nanoparticle and use thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62226817A (en) * 1986-03-18 1987-10-05 イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− Coated chromium dioxide particle
JPH08505625A (en) * 1993-01-11 1996-06-18 ダナ−ファーバー キャンサー インスティチュート Induction of cytotoxic T lymphocyte response
JP2001511820A (en) * 1997-11-25 2001-08-14 デイド、ベーリング、インコーポレイテッド Cyclosporin derivatives and uses thereof
WO2004087765A1 (en) * 2003-03-31 2004-10-14 Toto Ltd. Titanium dioxide complex having molecule distinguishability
WO2006025627A1 (en) * 2004-09-03 2006-03-09 Yonsei University Water-soluble nanoparticles stabilized with multi-functional group ligands and method of preapation thereof
JP2007269770A (en) * 2006-03-09 2007-10-18 Mitsubishi Chemicals Corp Functional magnetic super-nanoparticle and use thereof

Also Published As

Publication number Publication date
JP2008222595A (en) 2008-09-25
JP5391387B2 (en) 2014-01-15

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