WO2008109080A3 - Nucleoside based proliferation imaging markers - Google Patents

Nucleoside based proliferation imaging markers Download PDF

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Publication number
WO2008109080A3
WO2008109080A3 PCT/US2008/002870 US2008002870W WO2008109080A3 WO 2008109080 A3 WO2008109080 A3 WO 2008109080A3 US 2008002870 W US2008002870 W US 2008002870W WO 2008109080 A3 WO2008109080 A3 WO 2008109080A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleoside
mammal
tissue
imaging markers
based proliferation
Prior art date
Application number
PCT/US2008/002870
Other languages
French (fr)
Other versions
WO2008109080A2 (en
Inventor
Hartmuth C Kolb
Joseph C Walsh
Robert M Yeh
Kai Chen
Umesh Gangadharmath
Brian Duclos
Vani P Mocharla
Farhad Karimi
Henry C Padgett
Qianwa Liang
Tieming Zhao
Original Assignee
Siemens Medical Solutions
Hartmuth C Kolb
Joseph C Walsh
Robert M Yeh
Kai Chen
Umesh Gangadharmath
Brian Duclos
Vani P Mocharla
Farhad Karimi
Henry C Padgett
Qianwa Liang
Tieming Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions, Hartmuth C Kolb, Joseph C Walsh, Robert M Yeh, Kai Chen, Umesh Gangadharmath, Brian Duclos, Vani P Mocharla, Farhad Karimi, Henry C Padgett, Qianwa Liang, Tieming Zhao filed Critical Siemens Medical Solutions
Publication of WO2008109080A2 publication Critical patent/WO2008109080A2/en
Publication of WO2008109080A3 publication Critical patent/WO2008109080A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical

Abstract

Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
PCT/US2008/002870 2007-03-01 2008-03-03 Nucleoside based proliferation imaging markers WO2008109080A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90422307P 2007-03-01 2007-03-01
US60/904,223 2007-03-01

Publications (2)

Publication Number Publication Date
WO2008109080A2 WO2008109080A2 (en) 2008-09-12
WO2008109080A3 true WO2008109080A3 (en) 2009-04-30

Family

ID=39596378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/002870 WO2008109080A2 (en) 2007-03-01 2008-03-03 Nucleoside based proliferation imaging markers

Country Status (2)

Country Link
US (1) US7928210B2 (en)
WO (1) WO2008109080A2 (en)

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GB0815831D0 (en) * 2008-09-01 2008-10-08 Imp Innovations Ltd Compounds
AU2009308217B2 (en) * 2008-10-24 2016-01-21 Ionis Pharmaceuticals, Inc. 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
KR101116234B1 (en) * 2009-10-29 2014-03-06 (주)퓨쳐켐 Aryl derivatives substituted with (3-fluoro-2-hydroxy)propyl group or pharmaceutically acceptable salts thereof, preparation method thereof, and phrmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient
GB0921573D0 (en) * 2009-12-10 2010-01-27 Ge Healthcare Ltd Iodine radiolabelling method
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
CA2795762C (en) 2010-04-08 2017-03-28 Siemens Medical Solutions Usa, Inc. Synthesis of 18f-labeled tracers in hydrous organic solvents
SG11201608538UA (en) * 2014-04-29 2016-11-29 Biosearch Technologies Inc Compounds compositions and methods including thermally labile moieties
CN106589027A (en) * 2016-11-23 2017-04-26 河南师范大学 Zidovudine derivative with antimicrobial activity and preparation method and application thereof
US11180756B2 (en) 2017-03-09 2021-11-23 Ionis Pharmaceuticals Morpholino modified oligomeric compounds
EP3641783A4 (en) * 2017-06-22 2021-03-10 University Of Virginia Patent Foundation Proton activated atomic medicine
WO2021030778A1 (en) 2019-08-15 2021-02-18 Ionis Pharmaceuticals, Inc. Linkage modified oligomeric compounds and uses thereof

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EP0417999A1 (en) * 1989-09-11 1991-03-20 The Wellcome Foundation Limited Antiviral compounds
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WO2003099342A1 (en) * 2002-05-22 2003-12-04 Abraham Edward H Labeled adenosine for use in positron emission tomography
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WO2004096138A2 (en) * 2003-04-25 2004-11-11 University Of Southern California [18f]-furanosylpurine derivatives and uses thereof
WO2005020885A2 (en) * 2003-05-21 2005-03-10 Isis Pharmaceuticals, Inc. Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
WO2005044312A1 (en) * 2003-10-31 2005-05-19 Bristol-Myers Squibb Pharma Company Novel chemical agents comprising an adenosine moiety or an adenosine analog moiety and an imaging moiety and methods of their use
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Publication number Publication date
WO2008109080A2 (en) 2008-09-12
US7928210B2 (en) 2011-04-19
US20090016958A1 (en) 2009-01-15

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